CN114728902B - 作为金属-β-内酰胺酶抑制剂的1-氨基磺酰基-2-羧基吡咯衍生物 - Google Patents

作为金属-β-内酰胺酶抑制剂的1-氨基磺酰基-2-羧基吡咯衍生物 Download PDF

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CN114728902B
CN114728902B CN202080080912.8A CN202080080912A CN114728902B CN 114728902 B CN114728902 B CN 114728902B CN 202080080912 A CN202080080912 A CN 202080080912A CN 114728902 B CN114728902 B CN 114728902B
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compound
group
infection
pyrrole
sulfamoyl
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CN114728902A (zh
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安德鲁·威尔金森
伊恩·库珀
大卫·奥尔
乔纳森·芬莱森
亚当·邦特
皮娅·阿佩尔克维斯特
汉斯·沃尔伯格
弗雷德里克·旺塞尔
詹姆斯·柯卡姆
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Infix Treatment Ltd
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Infix Treatment Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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CN202080080912.8A 2019-11-20 2020-11-19 作为金属-β-内酰胺酶抑制剂的1-氨基磺酰基-2-羧基吡咯衍生物 Active CN114728902B (zh)

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CN202411235522.XA CN119100967A (zh) 2019-11-20 2020-11-19 作为金属-β-内酰胺酶抑制剂的1-氨基磺酰基-2-羧基吡咯衍生物

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