KR102940573B1 - 메탈로-베타-락타마제 저해제로서의 1-아미노설포닐-2-카르복시피롤 유도체 - Google Patents
메탈로-베타-락타마제 저해제로서의 1-아미노설포닐-2-카르복시피롤 유도체Info
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- KR102940573B1 KR102940573B1 KR1020227019182A KR20227019182A KR102940573B1 KR 102940573 B1 KR102940573 B1 KR 102940573B1 KR 1020227019182 A KR1020227019182 A KR 1020227019182A KR 20227019182 A KR20227019182 A KR 20227019182A KR 102940573 B1 KR102940573 B1 KR 102940573B1
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- South Korea
- Prior art keywords
- compound
- infection
- pharmaceutically acceptable
- solvate
- hydrate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/415—1,2-Diazoles
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- A61K31/4164—1,3-Diazoles
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- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1916915.0 | 2019-11-20 | ||
| GBGB1916915.0A GB201916915D0 (en) | 2019-11-20 | 2019-11-20 | Compounds |
| PCT/GB2020/052961 WO2021099793A1 (en) | 2019-11-20 | 2020-11-19 | 1-aminosulfonyl-2-carboxypyrrole derivatives as metallo-beta-lactamase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20220103978A KR20220103978A (ko) | 2022-07-25 |
| KR102940573B1 true KR102940573B1 (ko) | 2026-03-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227019182A Active KR102940573B1 (ko) | 2019-11-20 | 2020-11-19 | 메탈로-베타-락타마제 저해제로서의 1-아미노설포닐-2-카르복시피롤 유도체 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12544359B2 (https=) |
| EP (1) | EP4061800A1 (https=) |
| JP (1) | JP7642635B2 (https=) |
| KR (1) | KR102940573B1 (https=) |
| CN (2) | CN114728902B (https=) |
| AU (1) | AU2020385668A1 (https=) |
| BR (1) | BR112022008938A2 (https=) |
| CA (1) | CA3156194A1 (https=) |
| GB (1) | GB201916915D0 (https=) |
| IL (1) | IL293015A (https=) |
| MX (1) | MX2022006109A (https=) |
| WO (1) | WO2021099793A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB202015885D0 (en) * | 2020-10-07 | 2020-11-18 | Infex Therapeutics Ltd | Synthesis of pyrrole acid derivatives |
| CN117050063B (zh) * | 2023-08-14 | 2024-02-09 | 宁夏佰斯特医药化工有限公司 | 一种三氟乙酸酯三氮唑衍生物的合成方法 |
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| AU2003216312A1 (en) | 2002-02-19 | 2003-09-09 | Northwestern University | NON-COVALENT INHIBITORS OF AmpC ss-LACTAMASE |
| GB201310542D0 (en) | 2013-06-13 | 2013-07-31 | Antabio Sas | Compounds |
| EP3096754B1 (en) | 2014-01-22 | 2018-08-29 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors |
| GB201521059D0 (en) * | 2015-11-30 | 2016-01-13 | Isis Innovation | Inhibitors of metallo-beta-lactamases |
| CN112165936B (zh) | 2018-05-14 | 2023-11-28 | 国立大学法人东海国立大学机构 | β-内酰胺酶抑制剂 |
| GB2578093B (en) | 2018-10-09 | 2020-11-18 | Verona Pharma Plc | Liquid pharmaceutical composition comprising RPL554 and HFA-134A |
| GB201916915D0 (en) | 2019-11-20 | 2020-01-01 | Amr Centre Ltd | Compounds |
| GB202015885D0 (en) * | 2020-10-07 | 2020-11-18 | Infex Therapeutics Ltd | Synthesis of pyrrole acid derivatives |
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| WO2021099793A1 (en) | 2021-05-27 |
| IL293015A (en) | 2022-07-01 |
| JP2023502415A (ja) | 2023-01-24 |
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