CN114728032A - A cosmetic composition containing Taraxacum officinale extract for improving skin - Google Patents
A cosmetic composition containing Taraxacum officinale extract for improving skin Download PDFInfo
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- CN114728032A CN114728032A CN202080079666.4A CN202080079666A CN114728032A CN 114728032 A CN114728032 A CN 114728032A CN 202080079666 A CN202080079666 A CN 202080079666A CN 114728032 A CN114728032 A CN 114728032A
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- skin
- bacteria
- taraxacum officinale
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention relates to a cosmetic composition for improving skin, comprising an extract of Taraxacum officinale (Taraxacum officinale) which activates the proliferation of lactic acid bacteria present in the skin, thereby enhancing beneficial bacteria in the skin, and inhibits harmful bacteria in the skin without killing the harmful bacteria, thereby exerting the effect of regulating the growth of beneficial bacteria and harmful bacteria in the skin.
Description
Technical Field
The present invention relates to a cosmetic ingredient composition for improving skin comprising an extract of Taraxacum officinale (Taraxacum officinale).
Background
The Microbiome (Microbiome) is a synthetic word representing the microbiota (microbiota) of a microbial community and the genome (genome) representing the chromosome group. Microbiome is a term focusing on the strain of microorganisms per se as compared to microbiome, which refers to microorganisms that live in the human body and have symbiotic relationships, and microbiome refers to genetically based studies and techniques of interaction between host organisms and microorganisms beyond the existing individual microorganism analysis studies. However, the microbial population and microflora, the microbiome, have recently been commonly referred to. The term of microbiome is more widely known as the intestinal microbiome, in which harmful bacteria are suppressed by the potency of lactic acid bacteria to expand intestinal lactic acid bacteria by ingestion of lactic acid bacteria, and both lactic acid bacteria and harmful bacteria belong to the microbiome.
One of the reasons why the microbiome has recently received much attention is that the possibility of being applicable to health and disease problems of humans has increased dramatically. After the relevance of microorganisms in vivo to metabolic-related diseases such as obesity and diabetes is revealed, the relevance to cancers, infections, immunity, mental diseases and the like is released, and a therapeutic agent based on a microorganism group is upgraded to be one of innovative treatment technologies. It is known that maintaining the balance of microbiome has an influence on the function of the human body, and as the research on microbiome related to obesity in the body is disclosed, the interest in the research on microbiome has increased.
The human microbiome market is currently forming, functional foods or health products centered on probiotics (probiotics) and prebiotics (prebiotics) account for 83% of the total market. With the rapid increase of the healthy functional probiotic market, the research and development demands are rapidly increased not only in the food field but also in the cosmetic, medical and therapeutic fields.
Recent studies on the application of microbiome to the skin have also been actively carried out. It has been found that, with the increase in Staphylococcus aureus (Staphylococcus aureus) and Propionibacterium acnes (Propionibacterium acnes), which are known as skin-harmful microorganisms, the decrease in Staphylococcus epidermidis (Staphylococcus epidermidis), which are known as skin-beneficial microorganisms, increases skin acne. Many studies have been made in the field of cosmetics for the purpose of preventing or restoring the above-mentioned situation, but most of them focus on the preservation effect of harmful bacteria.
(patent document 0001) korean registered patent No. 10-1376202 (2014.03.13) discloses a pharmaceutical composition for preventing or treating skin diseases, which contains a mixed extract of dandelion and barley.
(patent document 0002) korean registered patent No. 10-1425757 (2014.07.25) discloses a skin massage composition for improving acne and a facial mask comprising the same.
Disclosure of Invention
Problems to be solved by the invention
The object of the present invention is to develop and provide a novel cosmetic ingredient composition having skin microbiome efficacy by using a probiotic material that increases the growth of lactic acid bacteria in the skin.
Means for solving the problems
The present invention provides a cosmetic ingredient composition for improving skin comprising an extract of Taraxacum officinale (Taraxacum officinale).
Preferably, in the cosmetic ingredient composition for improving skin of the present invention, the skin improvement is an improvement of acne-prone skin and an improvement in skin oil/moisture balance.
Preferably, the cosmetic composition for improving skin of the present invention promotes the growth of beneficial bacteria on the skin and inhibits the growth of harmful bacteria on the skin.
Preferably, in the cosmetic ingredient composition for improving skin of the present invention, the beneficial bacteria are Lactobacillus plantarum (Lactobacillus plantarum) and Staphylococcus epidermidis (Staphylococcus epidermidis).
Preferably, in the cosmetic ingredient composition for improving skin of the present invention, the above harmful bacteria are staphylococcus aureus (staphylococcus aureus) and Propionibacterium acnes (Propionibacterium acnes).
Effects of the invention
The cosmetic ingredient composition of the present invention can enhance skin-beneficial bacteria by activating the proliferation of lactic acid bacteria present in the skin, and inhibit skin-harmful bacteria without killing them, thereby exerting the effect of regulating the growth of skin-beneficial bacteria and harmful bacteria.
Brief description of the drawings
Fig. 1 is a graph showing the results of evaluating the regulating efficacy of lactobacillus dermaticus (l.plantarum), beneficial bacteria (s.epidermidis) and harmful bacteria (s.aureus and p.ane) of example 1;
FIG. 2 is a schematic view showing the results of confirming the change in skin oil/water content and pH of the subject when the treatment of example 1 was performed;
FIG. 3 is a graph showing the results of confirming the change in bacterial porphyrin when the treatment of example 1 was performed;
FIG. 4 is a schematic representation of the results of confirming changes in the distribution of skin microorganisms when the treatment of example 1 is performed (Bad) (Staphylococcus aureus), Staphylococcus aureus (Staphylococcus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Corynebacterium jejunum (Corynebacterium jeikeium), Corynebacterium diphtheriae (Corynebacterium diphtheria), Streptococcus pyogenes (Streptococcus pyogenes), Streptococcus crisis (Streptococcus cristatus), Acinetobacter (Acinetobacter junii), Fenugoni magnum (Finegomamaa), Stenotrophomonas maltophilia, Corynebacterium pseudogenital (Corynebacterium euonymus), acne (P.acnes), Propionibacterium (Propionibacterium propionicum), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Streptococcus pyogenes (Pseudomonas aeruginosa), Streptococcus salivarius (Streptococcus faecalis), Pseudomonas aeruginosa (Staphylococcus aureus), Streptococcus salivarius), Pseudomonas aeruginosa (Streptococcus faecalis), Pseudomonas salivarius (Streptococcus faecalis), Streptococcus faecalis (Streptococcus faecalis), Pseudomonas aeruginosa, Streptococcus faecalis (Streptococcus faecalis), Pseudomonas aeruginosa, Staphylococcus (P.P.P.P.P., pseudomonas mildans (Acidovorax temperans), Dietzia (Dietzia maris), Rhizobium japonicum (Bradyrhizobium japonicum), Acinetobacter calcoaceticus (Acinetobacter calcoaceticus), Good (Good), Lactobacillus paracasei (Lactobacillus paracasei) HS-05, Lactobacillus rhamnosus (Lactobacillus rhamnosus) HK-9, Bacillus licheniformis (Bacillus licheniformis), Bacillus subtilis (Bacillus subtilis).
Best mode for carrying out the invention
The present invention provides a cosmetic ingredient composition for improving skin comprising an extract of Taraxacum officinale (Taraxacum officinale).
Detailed Description
Probiotics function to regulate the composition of the microbiome, which also applies to the microbiome of the skin. Representative examples of the probiotics are lactic acid bacteria, which play a role in inhibiting harmful bacteria using a substance called bacteriocin (bacteriocin). The effectiveness of specific lactic acid bacteria and metabolites against skin diseases such as allergy can be confirmed by the existing studies.
However, the use of probiotics as cosmetic materials has difficulty in practical production because the microbial limit is exceeded. Therefore, there is a need to develop materials with the efficacy of the skin microbiome using probiotics that increase the growth of lactic acid bacteria in the skin.
Accordingly, the present invention provides a cosmetic ingredient composition for improving skin comprising an extract of Taraxacum officinale (Taraxacum officinale).
In the case of a material containing a saccharide which is widely known as a nutrient source of probiotics, there is a possibility that the formulation may be unstable when applied to cosmetics in the future. Therefore, the applicant selected the material of the present invention after confirming that the probiotic efficacy of Taraxacum officinale (Taraxacum officinale) is excellent.
Preferably, in the cosmetic ingredient composition for improving skin of the present invention, the skin improvement is an improvement of acne-prone skin and an improvement in skin oil/moisture balance. The following experiments confirmed that the dandelion extract of the present invention is effective in improving the lipid/water balance.
Preferably, the cosmetic composition for improving skin of the present invention promotes the growth of beneficial bacteria on the skin and inhibits the growth of harmful bacteria on the skin. In this case, the beneficial bacteria are preferably Lactobacillus plantarum (Lactobacillus plantarum) and Staphylococcus epidermidis (Staphylococcus epidermidis), and the harmful bacteria are preferably Staphylococcus aureus (Staphylococcus aureus) and Propionibacterium acnes (Propionibacterium acnes).
In the following experiments, it was confirmed that the dandelion extract of the present invention was effective in increasing the growth of Lactobacillus plantarum (Lactobacillus plantarum) and Staphylococcus epidermidis (Staphylococcus epidermidis) as skin-beneficial bacteria, and simultaneously reducing the growth of Staphylococcus aureus (Staphylococcus aureus) and Propionibacterium acnes (Propionibacterium acnes) as skin-harmful bacteria. In particular, the cosmetic preservative kills Staphylococcus epidermidis (Staphylococcus epidermidis) which is a skin-benefiting bacterium and disrupts the balance of microbiome, but the dandelion extract of the present invention, as a result of experiments performed after treatment with a preservative formulation at a concentration suitable for the finished product, shows that it can be confirmed that the growth of Staphylococcus epidermidis (Staphylococcus epidermidis) is increased (not shown), and thus the above-mentioned problems can be eliminated.
In the present invention, the extract is preferably contained in an amount of 0.00001 to 30.0 wt% based on the total weight of the cosmetic composition. More preferably, the cosmetic composition contains 0.01 to 10.0 wt% of the total weight of the cosmetic composition. In the case where the content of the mixed extract is less than 0.00001% by weight, the skin-improving effect including improvement of acne-prone skin and improvement of skin oil/moisture balance is not exhibited, and in the case where it exceeds 30.0% by weight, the effect is not remarkably increased with increase in the content.
The ingredients contained in the cosmetic ingredient composition of the present invention may include, as active ingredients, ingredients generally used in cosmetic ingredient compositions other than the mixed extract of the present invention, and include, for example, conventional adjuvants and carriers such as antioxidants, stabilizers, solubilizers, vitamins, pigments, and perfumes.
The cosmetic ingredient composition of the present invention may be prepared in any form commonly used in the art, for example, but not limited to, a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing facial cleanser, an oil, a foundation cream, a foundation lotion, a foundation wax, a mask, a massage cream, and a spray. More specifically, the cosmetic can be made into dosage forms of soft lotion, nourishing cream, massage cream, essence, eye cream, facial wash, facial foam, facial cleanser, facial mask spray or powder.
When the cosmetic ingredient composition of the present invention is in the form of a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, a cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc or zinc oxide, etc. can be used as a carrier component.
When the formulation of the cosmetic ingredient composition of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier ingredient, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.
When the cosmetic composition of the present invention is in the form of a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester or polyoxyethylene sorbitan ester, microcrystalline cellulose, m-aluminum hydroxide, bentonite, agar or tragacanth can be used as a carrier component.
When the formulation of the cosmetic ingredient composition of the present invention is powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, or the like can be used as a carrier component, and particularly when spray is used, a propellant such as chlorofluorocarbon, propane/butane, or dimethyl ether can be additionally contained.
In the case where the formulation of the cosmetic ingredient composition of the present invention is a surfactant-containing facial cleanser formulation, fatty alcohol sulfate, fatty alcohol ether sulfate, sulfosuccinic acid monoester, isethionic acid salt, imidazoline salt derivative, methyltaurate, sarcosinate, fatty acid amide ether sulfate, cocamidopropyl betaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, ethoxylated glycerol fatty acid ester, or the like can be used as a carrier ingredient.
In the case where the cosmetic ingredient composition of the present invention is in the form of a surfactant-containing facial cleanser or a surfactant-free facial cleanser, it may also be wiped off or peeled off or rinsed with water after application to the skin. As specific examples, the soap is a liquid soap, a powdered soap, a solid soap, and an oil soap, the surfactant-containing facial cleanser forms are a facial cleansing foam, a facial cleanser, a facial towel, and a facial mask, and the surfactant-free facial cleanser forms are a facial cream, a facial cleanser, and a facial gel, but not limited thereto.
The structure of the present invention will be described in detail with reference to the following examples and experimental examples. However, the scope of the present invention is not limited to the following examples and experimental examples, and includes modifications of technical ideas equivalent thereto.
(Experimental example 1 isolation and identification of lactic acid bacteria in skin)
The skin surface microorganisms of face, cheek and palm were wiped with 44 male and female subjects. And (4) placing the swabbed cotton swab into a tube for enrichment culture, and then culturing the culture solution in BHI agar culture medium to obtain bacterial colonies. After each of the single colonies was cultured in BHI medium, sequence analysis was requested to MACROGEN, Inc. for distinguishing lactic acid bacteria of the cultured strain.
Adherence of the isolated strain the base sequence was analyzed using the 16S rRNA method, showing 99% homology with the standard strain, conserved in the center of biological resources and assigned the conservation number of SD 1323. The isolated lactic acid bacterium was named Lactobacillus plantarum RD-02, and in order to confirm the efficacy of the extract of the present invention on skin lactic acid bacteria, it was used in the following experiment.
Example 1 production of Taraxacum officinale extract of the present invention
Pulverizing dried herba Taraxaci into powder with pulverizer. 50g of Taraxacum officinale powder and 1L of purified water were mixed, and the mixture was stirred at 20 to 25 ℃ for 1 hour with a stirrer to prepare an extract solution. After the extract solution was once filtered through a nonwoven fabric filter, the once filtered solution was filtered under reduced pressure through No.5C filter paper.
(Experimental example 2 evaluation of efficacy of regulating skin microorganism)
To evaluate the skin microorganism-regulating effect, "plant lactic acid bacterium RD-02(Lactobacillus plantarum RD-02) and Staphylococcus epidermidis (Staphylococcus epidermidis)", "plant lactic acid bacterium RD-02(Lactobacillus plantarum RD-02) and Staphylococcus aureus (Staphylococcus aureus)", "plant lactic acid bacterium RD-02(Lactobacillus plantarum RD-02) and Propionibacterium acnes (Propionibacterium acnes)" as skin lactic acid bacteria were mixed at the same concentration and cultured together, and the treatment with the taraxacum officinale extract was performed. After the culture broth was diluted and spread on an agar medium, colonies of each microorganism were counted to confirm the change in the number of microorganisms.
The test results showed that the taraxacum officinale extract activated the proliferation of the plant lactic acid bacterium RD-02 (custody No. SD1323) as a skin lactic acid bacterium, thereby significantly increasing the growth of staphylococcus epidermidis as a skin beneficial bacterium and significantly reducing the growth of staphylococcus aureus (staphylococcus aureus) and Propionibacterium acnes as skin harmful bacteria (fig. 1). Fig. 1 is a graph illustrating the results of evaluating the regulating effects of lactobacillus dermaticus (l.plantarum), beneficial bacteria (s.epidermidis) and harmful bacteria (s.aureus and p.ane) of example 1.
(Experimental example 3 evaluation of skin safety)
To confirm skin safety, a human patch experiment was performed. The sample diluted with the Finn chamber kit was applied to the back of the arm of 20 healthy adult women and fixed to the skin. The criteria for determination follow the criteria of the international contact dermatitis research group. The experimental results showed that the dandelion extract of the present invention was not irritating (table 1).
[ TABLE 1 ]
(Experimental example 4 evaluation of skin improving Effect)
In order to confirm the effect of improvement when actually applied to the skin, the diluted sample of example 1 (concentration of 0.05% by dry weight) was applied to the skin, and then changes in the oil/water content, pH, bacterial porphyrin and microorganisms of the skin were confirmed.
Grease/moisture and pH measurements were done with Soft Plus instrument from callegaris r.l. while bacterioporphyrin measurements were done with OBSERV instrument from Sylton diagnostic system. Skin microbial changes were entrusted to SHEBAH BIOTECH for analysis.
The results of the experiment show that the oil/moisture value of the skin is improved to the level of normal skin by the treatment of example 1. The average values for all subjects showed a 10% improvement in moisture and a 20% improvement in grease (figure 2). Fig. 2 is a schematic diagram showing the results of checking the change in skin oil/water content and pH of the subject when the treatment of example 1 was performed.
The bacterial porphyrins were reduced by about 25% when treated with example 1. This value was derived for bacterial porphyrins at the tip of the nose, and a decrease in the number of points indicating bacterial porphyrins was observed also at a site other than the tip of the nose (fig. 3). FIG. 3 is a graph showing the results of confirming the change in bacterial porphyrin when the treatment of example 1 was performed.
In addition, the results of confirming the change in microbial distribution indicate that the distribution of the microbial communities of the bad type (bad type) and the p.ane community decreased while the distribution of the microbial communities of the normal type (normal type) and the good type (good type) increased when the treatment of example 1 was performed (fig. 4). FIG. 4 is a graph showing the results of confirming changes in the distribution of skin microorganisms when the treatment of example 1 is performed (Bad) (Staphylococcus aureus), Pseudomonas aeruginosa, Corynebacterium jejuni, Corynebacterium diphtheriae (Corynebacterium diphenoxy), Streptococcus pyogenes (Streptococcus pyogenenes), Streptococcus crisis (Streptococcus cristatus), Acinetobacter johnsonii (Acinetobacter junii), Fenugoniella macrocephalus (Finego magna), Stenotrophomonas maltophilia, Corynebacterium pseudorhizogenes (Corynebacterium parvum), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Pseudomonas aeruginosa (Pseudomonas aeruginosa). Pseudomonas mildenes (Acidovorax temperans), Alzheimer's disease (Dietzia maris), Rhizobium sojae (Bradyrhizobium japonicum), Acinetobacter calcoaceticus (Acinetobacter calcoaceticus), Good (Good) Lactobacillus paracasei (Lactobacillus paracasei) HS-05, Lactobacillus rhamnosus (Lactobacillus rhamnosus) HK-9, Bacillus licheniformis (Bacillus licheniformis), Bacillus subtilis (Bacillus subtilis).
Industrial applicability
The present invention relates to a cosmetic ingredient composition for improving skin comprising an extract of Taraxacum officinale (Taraxacum officinale).
Claims (5)
1. A cosmetic composition for improving skin contains Taraxacum officinale extract.
2. The cosmetic ingredient composition for improving skin according to claim 1, characterized in that: the skin improvement is the improvement of acne-prone skin, and the improvement of skin oil/water balance.
3. The cosmetic ingredient composition for improving skin according to claim 1, characterized in that: the cosmetic composition can promote the growth of beneficial bacteria in skin and inhibit the growth of harmful bacteria in skin.
4. The cosmetic ingredient composition for improving skin according to claim 3, characterized in that: the beneficial bacteria are Lactobacillus plantarum and Staphylococcus epidermidis.
5. The cosmetic ingredient composition for improving skin according to claim 3, characterized in that: the harmful bacteria are Staphylococcus aureus and Propionibacterium acnes.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2019-0143775 | 2019-11-11 | ||
| KR1020190143775A KR102121006B1 (en) | 2019-11-11 | 2019-11-11 | Cosmetic composition for improvement of skin with Taraxacum officinale |
| PCT/KR2020/015654 WO2021096186A1 (en) | 2019-11-11 | 2020-11-09 | Cosmetic composition for skin improvement comprising taraxacum officinale leaf extract |
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| CN114728032A true CN114728032A (en) | 2022-07-08 |
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| CN202080079666.4A Pending CN114728032A (en) | 2019-11-11 | 2020-11-09 | A cosmetic composition containing Taraxacum officinale extract for improving skin |
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| KR (1) | KR102121006B1 (en) |
| CN (1) | CN114728032A (en) |
| WO (1) | WO2021096186A1 (en) |
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| KR102121006B1 (en) * | 2019-11-11 | 2020-06-09 | 주식회사 래디안 | Cosmetic composition for improvement of skin with Taraxacum officinale |
| KR102270709B1 (en) | 2021-04-15 | 2021-06-28 | 경호빈 | Cosmetic composition for skin improvement containing complex ceramide and natural extracts |
| KR102386262B1 (en) | 2022-01-17 | 2022-04-14 | 주식회사 지웨이코스메틱 | Cosmetics composition with Extract of Sparassis crispa Wulf. ex Fr. and extract of Taraxacum officinale leaf and fermentation lysate of Lactobacillus and palm oil fraction |
| KR102565684B1 (en) * | 2023-04-13 | 2023-08-10 | 주식회사 에스지엔바이오 | Cosmetic composition for improving acne containing Taraxacum platycarpum extract, vitamins and peptides as active ingredients |
| KR102604529B1 (en) * | 2023-06-30 | 2023-11-23 | 박준한 | Cosmetic composition for skin improvement containing stem cell culture |
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| KR100771397B1 (en) * | 2006-06-08 | 2007-10-30 | 인제대학교 산학협력단 | Cosmetic composition comprising an extract of dandelion or luteolin isolated therefrom having anti-oxidant activity and anti-inflammatory activity |
| KR100982883B1 (en) * | 2008-12-12 | 2010-09-16 | 주식회사 아데나 | Cosmetic composition comprising mixture extract and preparation thereof |
| KR101376202B1 (en) | 2012-05-15 | 2014-03-26 | 한국원자력연구원 | Pharmaceutical composition containing extract of mongolian dandelion and barley for the provention or treatment of skin disease |
| KR101425757B1 (en) | 2013-09-12 | 2014-08-05 | 김태홍 | Herbal skin massage composition and the mask pack comprising the same |
| KR101901451B1 (en) * | 2018-01-23 | 2018-09-27 | (주)해피엘앤비 | Cosmetic composition containing flower extracts prepared by a method based on natural deep eutectic Solvents |
| KR102121006B1 (en) * | 2019-11-11 | 2020-06-09 | 주식회사 래디안 | Cosmetic composition for improvement of skin with Taraxacum officinale |
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- 2019-11-11 KR KR1020190143775A patent/KR102121006B1/en active IP Right Grant
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2020
- 2020-11-09 CN CN202080079666.4A patent/CN114728032A/en active Pending
- 2020-11-09 WO PCT/KR2020/015654 patent/WO2021096186A1/en active Application Filing
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| CN105582036A (en) * | 2014-11-06 | 2016-05-18 | 株式会社Lg生活健康 | Composition for promoting synthesis of hyaluronic acid comprising Taraxacum herbs extracts and the use thereof |
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