CN106714779A - Cosmetic composition for improving skin wrinkles - Google Patents
Cosmetic composition for improving skin wrinkles Download PDFInfo
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- CN106714779A CN106714779A CN201580052455.0A CN201580052455A CN106714779A CN 106714779 A CN106714779 A CN 106714779A CN 201580052455 A CN201580052455 A CN 201580052455A CN 106714779 A CN106714779 A CN 106714779A
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- rheum officinale
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention relates to a mixture of taraxicum officinalis, eisenia bicyclis, eriobotrya japonica leaf, and Ampelopsis japonica Makino extracts. The present invention comprises safe natural agents, thus does not cause side effects, and provides the advantages of improving wrinkles and increasing elasticity by promoting collagen production, inhibiting the expression of collagenase (MMP-1), and increasing the expression of type-1 procollagen.
Description
Technical field
Cosmetic composition the present invention relates to be used to improve wrinkle of skin, the composition comprising medicinal herbs (Chinese medicine,
Medicinal herbs) combined extracts (mixed extract, combined extract).
Background technology
The reason for wrinkle of skin, is classified broadly into natural aging and the exposure (that is, light aging) to UV radiation.As this two
The mechanism for planting the wrinkle of skin formation of the result of reason is not understood definitely also.It was found that cause with natural aging and light aging
The related common manifestation of change of skin is due to the collagen of major structural protein matter as corium and subtracting for elastin laminin
Less and deformation and as corium substrate hyaluronic acid reduction caused by skin elasticity deterioration.According to currently acquired
Result of study, specifically, it is known that be as the collagen and elastin laminin of the major structural protein matter of corium reduction and
Deformation is directly related to wrinkle of skin and is formed and skin elasticity deterioration.
Collagen, a kind of main component of extracellular matrix is a kind of main matrix of generation in SF
Protein.And, used as a kind of key protein for accounting for bioprotein gross weight 30%, collagen has rigid three spiral shell
Rotation structure.The major part of its organic substance for also forming skin, tendon, bone and tooth, is especially rich in bone and skin.
The amount of collagen is reduced with the age and exposed to the radiogenic light aging of UV.The known fact is wrinkled with skin
The formation of line has substantial connection.Additionally, collagen plays an important role in During Wound Healing；By promoting to be damaged in epidermis
The synthesis of collagen can make healing wound fast without scar.
In the past, there are many business for being applied in combination collagen and composition for external application (such as cosmetics or ointment) to produce
Product, with using the skin moisture-keeping and Wound Healing of collagen.However, these products are only applied in itself as collagen
Use skin surface and there is difficulty on belonging to the percutaneous absorbtion of the collagen of macromolecular class, thus in skin moisture-keeping or
Wound healing aspect is not almost acted on.Therefore, it is not considered as that such product has the work(for improving skin function or healing wounds
Effect.
In order to solve the problem, to there is growing interest for the material for promoting collagen synthesis, it is known that
Promoting the material of collagen synthesis can include, for example, vitamin C, retinoic acid, the protein from animal placenta, birch
Wood acid, green algal extract etc..
However, these materials due to safety issue as when applied to the skin stimulation and it is rubescent and in terms of its consumption
It is restricted and effect is not notable, therefore they are not expected at improvement skin function or healing wounds aspect works.Therefore,
Urgently need exploitation has security and more preferable effect higher than the existing composition for improving wrinkle of skin
The new composition for improving wrinkle of skin.
The content of the invention
Technical problem
Therefore one object of the present invention is to provide in terms of improving wrinkle of skin and increasing skin elasticity has effect
Cosmetic composition.
It is a further object to provide the method for improving wrinkle of skin, methods described includes applying effective dose
Dandelion (Taraxaci Herba), rheum officinale (Rhei Rhizoma), loguat leaf (Eriobotryae Folium) and radix ampelopsis
The combined extracts of (Ampelopsis Radix).
The combined extracts that further another purpose of the invention is to provide dandelion, rheum officinale, loguat leaf and radix ampelopsis exist
Prepare for improve wrinkle of skin cosmetic composition in purposes.
Technical scheme
In cosmetic composition of the exploitation with the effect for improving wrinkle of skin and increasing skin elasticity is attempted, the present invention
Inventor find following facts, i.e. dandelion (Taraxaci Herba), rheum officinale (Rhei Rhizoma), loguat leaf
The combined extracts of (Eriobotryae Folium) and radix ampelopsis (Ampelopsis Radix) are improving wrinkle of skin and increase
Skin elasticity aspect is highly effective, so as to complete the present invention.
The present invention provides the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis.
Using by mix four kinds of synergies of medicinal herbs, dandelion of the invention, rheum officinale, loguat leaf and radix ampelopsis
Combined extracts cytotoxicity compared with individual medicinal herbs is lower and more has in terms of improving wrinkle of skin and increasing skin elasticity
Effect.
In the present invention, dandelion (Taraxaci Herba) refers to the composite family for being distributed widely in South Korea, China etc.
(Compositae) whole plant of dandelion (Taraxacum platycarpum H.) or other congeners in.
In the present invention, rheum officinale (Rhei Rhizoma) is the polygonaceae for being distributed widely in South Korea, China etc.
(Polygonaceae) the species sorrel (Rheum palmatum L.) in, Rheum tanguticum Maxim (Rheum tanguticum
M) or Rheum officinale (Rheum officinale B.) dry rhizome.
In the present invention, loguat leaf (Eriobotryae Folium) refers to be distributed widely in South Korea, China, Japan etc.
Eriobotryajaponica L.'s in the rose family (Rosaceae) dries leaf.
In the present invention, radix ampelopsis (Ampelopsis Radix) is the Vitaceae for being distributed widely in China, South Korea etc.
(Vitaceae) dry root of the Ampelopsis japonica Makino belonged to as climbing stem plant in.
These medicinal herbs that easily can be obtained from home or overseas with low cost can simply be bought or harvesting by hand.
In the present invention, the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis can be the mixture of single medicinal herbs
Extract or single medicinal herbal extract mixture.Preferably, combined extracts of the invention as from dandelion, rheum officinale,
The extract that the herb mixture of loguat leaf and radix ampelopsis is obtained is used.In the present invention, combined extracts can with concentrate or
The form of freeze-dried powder is obtained.
The gross weight of the combined extracts based on dandelion, rheum officinale, loguat leaf and radix ampelopsis, combined extracts of the invention can
With the dandelion comprising 30 to 50 weight %, the rheum officinale of 15 to 30 weight %, 15 to 30 weight % loguat leaf and 10 to 20 weights
Measure the radix ampelopsis of %, the preferably dandelion of 35 to 50 weight %, the rheum officinale of 17 to 30 weight %, the loguat leaf of 17 to 30 weight %
With the radix ampelopsis of 15 to 20 weight %.
It is highly preferred that the weight ratio of dandelion, rheum officinale, loguat leaf and radix ampelopsis in combined extracts of the invention can be
4: 2: 2: 1.5 (being based on weight ratio).
With single medicinal herbal extract or two or more medicinal herbs combined extracts each compared with, to limit above
Fixed percentage by weight contains all four kinds of combined extracts of the invention of medicinal herbs to be improved wrinkle of skin and is increasing skin bullet
Property aspect, particularly suppress MMP-1 expression and promote 1 type procollagen (procollagen) synthesis aspect show it is significantly excellent
Effect, therefore cause activity higher in terms of improving wrinkle of skin and increasing skin elasticity.
In the present invention, the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis can be extracted by hot water, soaked
It is prepared by extraction, refluxing extraction, ultrasonic extraction etc..The number of times of extraction is preferably 1 to 5 time.The example of Extraction solvent includes, but does not limit
In, water and C1-C4Alcohol or its mixture, preferably water or ethanol water.The amount of the Extraction solvent used in extraction process is public Pu
2 to 15 times of the gross weight of English, rheum officinale, loguat leaf and radix ampelopsis.In order to obtain hot water (water) extract, water-bath refluxing extraction can be with
One to four time up to 2 to 24 hours, preferably 2 to 10 hours are repeated at 100 to 110 DEG C.
What the combined extracts that the present invention also provides by further separating dandelion, rheum officinale, loguat leaf and radix ampelopsis were obtained
The fraction (fraction) of the combined extracts from dandelion, rheum officinale, loguat leaf and radix ampelopsis.Fraction is separated and can use ability
Separation method is carried out known to field technique personnel.Preferably, four kinds of medicinal herbs dandelions, rheum officinale, loguat leaf and radix ampelopsis are suspended in
In water, then extracted with solvent such as hexane, chloroform, ethyl acetate, butanol etc., obtain dandelion, rheum officinale, loguat leaf and radix ampelopsis
Soluble fraction.
The present invention also provides cosmetic composition for improving wrinkle of skin, its include dandelion, rheum officinale, loguat leaf and
The combined extracts of radix ampelopsis.
The combined extracts of dandelion of the invention, rheum officinale, loguat leaf and radix ampelopsis are due to having used the natural of safety
Composition and do not cause when skin is applied to side effect and increase skin elasticity and improve wrinkle of skin in terms of show excellent
Effect, since it demonstrates that being effective in terms of suppressing MMP-1 expression and increasing by 1 type procollagen synthesis, thus shows conduct
Excellent effect for improving the cosmetic composition of wrinkle of skin.
With single medicinal herbal extract person two or more medicinal herbs combined extracts each compared with, according to the present invention
The combined extracts comprising dandelion, rheum officinale, loguat leaf and radix ampelopsis the cosmetic composition for improving wrinkle of skin, by
In the synergy of the component by combining medicinal herbs dandelion, rheum officinale, loguat leaf and radix ampelopsis, and show in terms of wrinkle of skin is improved
Show excellent effect.In other words, combined extracts comprising dandelion, rheum officinale, loguat leaf and radix ampelopsis of the invention are used for
The new cosmetic compositions of improvement wrinkle of skin are before suppressing the expression of clostridiopetidase A (being referred to as MMP-1) and increasing collagen
The biosynthesis aspect of body (being referred to as 1 type procollagen) all significantly effectively, causes to improve the excellent effect of wrinkle of skin, and uses
The composition of each individual medicinal herbs can not simultaneously suppress MMP-1 expression and increase the synthesis of 1 type procollagen.Especially, dandelion by
It is considered as in human body to be used with low concentration in its cytotoxicity high, but the composition of combination of the invention is by making
Solution is provided and compared with each single extract in suppression to the problem of cytotoxicity with the combination of medicinal herbs
MMP-1 expresses and increases the significantly excellent effect of 1 type procollagen synthesis aspect display.
In the present invention, the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis can be in the form of powder or liquid
With 0.001 to 10 weight % of the gross weight based on cosmetic composition, the preferably amount of 0.01 to 5 weight % is added to and makes up
In product composition.
In addition to the combined extracts of the dandelion as active component, rheum officinale, loguat leaf and radix ampelopsis, of the inventionization
The component of cosmetic compositions can also include the conventional composition in cosmetic composition, and it includes, for example, standard adjuvant (for example,
Antioxidant, stabilizer, solubilizer, vitamin, pigment, colouring agent and spices) and carrier.
Cosmetic composition of the invention can be formulated into any type of dosage form of typical case's preparation in this area,
The example include, but not limited to solution, supensoid agent, emulsion, paste, gel, creme, lotion, pulvis, soap, containing surface-active
Cleaning agent, oil, foundation cream, foundation cream breast (emulsion foundation), foundation cream wax (wax foundation), spray of agent etc..
More particularly, cosmetic composition of the invention can be formulated into skin soft agent, facial scrubs (face cream, face
Lotions), nourishing cream, massage cream, Essence, facial mask (pack), eye cream, washing cream, face cleaning foam (mildy wash,
Cleansing foam), face cleaning water (makeup remover, cleansing water), facial mask, the preparation shape of spray (spray) or pulvis
Formula.
When dosage form of the invention is paste, creme or gel, animal oil, vegetable oil, wax, paraffin, starch, yellow alpine yarrow
Glue, cellulose derivative, polyethylene glycol, silicone (organosilicon, silicone), bentonite, silica, talcum or zinc oxide etc.
It is used as carrier component.
When dosage form of the invention be pulvis or spray when, lactose, talcum, silica, aluminium hydroxide, calcium silicates or
Polyamide powder is used as carrier component.Especially, if it is spray, it can additionally contain propellant, such as
CFC, propane/butane or dimethyl ether.
When dosage form of the invention is solution or emulsion, solvent, solubilizer or emulsifying agent are used as vehicle group
Point, the example can include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzylalcohol, Ergol, propane diols, fourth two
Alcohol, 1,3-BDO oil, Crodaret, glycerine, glycerine, aliphatic ester, phenoxetol, triethanolamine,
Polyethylene glycol, wax, polysorbate60, Arlacel-83, paraffin, sorbitan monostearate, lipophilicity
It is glycerin monostearate, stearic acid, tristerin/PEG-400 stearates, carboxyl polymer, cytosterol, poly- sweet
Oily 2- oleates, ceramide, cholesterine, steareth-4, DCP, Australia nut oil (macadamia oil),
Aliphatic ester of carboxyl vinyl polymer, xanthans or anhydro sorbitol etc..
When dosage form of the invention is supensoid agent, liquid diluent (for example, water, ethanol, butanediol or propane diols),
Suspending agent (for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitan ester or Sorbitan ethoxylate), microcrystalline cellulose
Element, hydroxyethyl cellulose, Sodium Hyaluronate, phenoxetol, meta-aluminic acid (aluminum metahydroxide), the de- soil of class,
Agar or bassora gum etc. are used as carrier component.
When dosage form of the invention is the cleaning agent containing surfactant, fatty alcohol sulfate, fatty alcohol ether sulfuric acid
Ester, monoesters sulfosuccinate (monoester sulfosuccinate), isethionic acid ester (isethionate), imidazoles
Derivative, methyl taurate, sarcosinate, aliphatic amide ether sulfuric ester (aliphatic amide ether
Sulfate), alkyl amido betaine, fatty alcohol, glyceryl fatty esters, aliphatic diglycollic amide, vegetable oil, lanolin spread out
Biological or ethoxylated glycerol fatty acid ester etc. is used as carrier components.
The present invention also provides method for improving wrinkle of skin, and methods described includes applying the dandelion of effective dose, big
Yellow, loguat leaf and the combined extracts of radix ampelopsis.
As used herein, term " effective dose " refer to for prevent or mitigate the dandelion of wrinkle of skin, rheum officinale,
The amount of the combined extracts of loguat leaf and radix ampelopsis.
Method for improving wrinkle of skin of the invention includes will be comprising dandelion, rheum officinale, loguat leaf and radix ampelopsis
The composition of combined extracts contacted with skin.As used herein, skin include, but not limited to face, neck,
The skin of arm and pin and leg.In the improvement of wrinkle of skin, the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis
Amount can according to the age of object, wrinkle formed process or skin target region and change.Enough combined extracts
Amount can consider these factors and determine by those skilled in the art.Additionally, the combination of dandelion, rheum officinale, loguat leaf and radix ampelopsis
Applied together with the other activating agent for helping to improve wrinkle of skin that extract can be with effective dose.
Method for improving wrinkle of skin of the invention can also include differentiating the target for needing to improve wrinkle of skin
Skin area.Discrimination process can be carried out by user or third party, and the third party includes, for example, dermatologist, beautician
Or another person.
The combined extracts that the present invention also provides dandelion, rheum officinale, loguat leaf and radix ampelopsis are being prepared for improving skin wrinkle
Purposes in the cosmetic composition of line.Combination for preparing dandelion, rheum officinale, loguat leaf and the radix ampelopsis of cosmetic composition
Extract can be combined with commercially available adjuvant, diluent etc., or can be applied in combination to produce association with another activating agent
Same-action.As used herein, the example of another activating agent can include UV blocking agents (UV blocks), NMF,
Exfoliator (exfoliators), softening agent, brightening agent etc..
Advantageous effects
The combined extracts of dandelion of the invention, rheum officinale, loguat leaf and radix ampelopsis due to using safety it is natural into
Divide without side effect and demonstrate in suppression MMP-1 expression and increase by 1 type procollagen synthesis, thus increase skin elasticity
It is effective with wrinkle of skin aspect is improved.
Brief description
Fig. 1 is shown in applying 1 type procollagen level after the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis
The figure of change.
Fig. 2 is shown in the change of MMP-1 activation after the combined extracts using dandelion, rheum officinale, loguat leaf and radix ampelopsis
Figure.
Preferred embodiment of the present invention
Hereinafter, reference implementation example and test example are described into the disclosure in further detail, provides institute
Stating embodiment and test example is used to understand the disclosure and is not intended to limit the scope of claim of the invention.
Embodiment 1：Prepare the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis
In order to prepare dandelion, rheum officinale, loguat leaf and the combined extracts of radix ampelopsis, medicinal herbs are bought from Omniherb Inc.；
Dandelion (derives from South Korea), rheum officinale (from China), loguat leaf (from China), radix ampelopsis (from China).Make
With preceding, each medicinal herbs is washed with water, then dried in the shade.
40g dandelions, 20g rheum officinales, 20g loguat leaves and 15g radix ampelopsis are put into 1L distilled water.Make gained at 100 DEG C
Mixture carries out refluxing extraction 4 hours by return duct, and is concentrated under vacuum, and obtains dandelion, rheum officinale, the loquat of 14g
Leaf and the combined extracts of radix ampelopsis.
For individual medicinal herbal extract, by 100g, each medicinal herbs mixes with 1L distilled water.Make at 100 DEG C thus obtained mixed
Compound carries out refluxing extraction up to 4 hours each via return duct, and is concentrated under vacuum, and respectively obtains the extraction of 20g dandelions
Thing, 28g Chinese rhubarb extracts, 12g loquat-leaf extracts and 16g Radix Ampelopsis extracts.
Test example 2：Combined extracts to dandelion, rheum officinale, loguat leaf and radix ampelopsis are used to promote the biology of 1 type procollagen
The evaluation of the effect of synthesis
Test program carries out promoting 1 type virgin rubber to evaluate the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis as follows
The effect of former biosynthesis.
HF is cultivated and with 10 in DMEM solution (10% hyclone, 1% antibiotic)4Individual cell/
The density in hole is inoculated into 24- orifice plates.After cell attachment is confirmed, DMEM solution is discarded.Then, by the dandelion of 0.5mL,
The combined extracts of rheum officinale, loguat leaf and radix ampelopsis are added in each hole, wherein the combined extracts are made into various concentrations
(that is, 50 μ g/mL, 100 μ g/mL and 200 μ g/mL), according to toxotest, are not observed toxicity at these concentrations.By people
Fibroblast is with 5%CO2In the incubator of purging 37 DEG C cultivate 48 hours, with measure the wrinkle in culture medium formed because
The cellular level of sub (that is, 1 type procollagen and Fibroblast collagenase).
Result shows in Fig. 1.
As shown in fig. 1, by HF with dandelion, rheum officinale, the loguat leaf of various concentrations (0 to 200 μ g/mL)
Combined extracts with radix ampelopsis process 48 hours to evaluate the anti-wrinkle effect in culture medium.As a result, being distinguished using concentration
It is the combined extracts of 50 μ g/mL, 100 μ g/mL and 200 μ g/mL, is referred to as the level of the collagen precursor of 1 type procollagen
It is increased significantly to 15.6% (p ＜ 0.05), 29.0% (p ＜ 0.01) and 34.4% (p ＜ 0.001).
That is, increasing by 1 type procollagen for generation instant invention overcomes caused by the cytotoxicity of individual medicinal herbs
Limitation in terms of the treating capacity of the individual medicinal herbal extract of the dandelion of effect, rheum officinale, loguat leaf or radix ampelopsis, and with individual medicine
Careless extract compares the effect of the type procollagen of increase by 1 for dramatically increasing.
Embodiment 3：Combined extracts to dandelion, rheum officinale, loguat leaf and radix ampelopsis suppress the biology of clostridiopetidase A (MMP-1)
The evaluation of the effect of synthesis
Test program carries out suppressing clostridiopetidase A to evaluate the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis as follows
(MMP-1) effect of biosynthesis.
HF is cultivated and with 10 in DMEM solution (10% hyclone, 1% antibiotic)4Individual cell/
The density in hole is inoculated into 24- orifice plates.After cell attachment is confirmed, DMEM solution is discarded.Then, by the dandelion of 0.5mL,
The combined extracts of rheum officinale, loguat leaf and radix ampelopsis are added in each hole, wherein the combined extracts are made into various concentrations.
By HF with 5%CO2Cultivate 48 hours to measure the MMP-1's in culture medium at 37 DEG C in the incubator of purging
Cellular level.
Result shows in fig. 2.
As shown in Figure 2, dandelion, rheum officinale, the Pi of 50 μ g/mL, 100 μ g/mL and 200 μ g/mL are respectively using concentration
Rake leaf or radix ampelopsis combined extracts treatment test group in, the level of clostridiopetidase A (MMP-1) to depend on concentration in the way of show
Work property ground (p ＜ 0.001) is reduced to 45.0%, 52.8% and 58.7%.
That is, instant invention overcomes caused by the cytotoxicity of individual medicinal herbs on being closed for suppressing the biological of MMP-1
Into effective dose the limitation in terms of the treating capacity of the individual medicinal herbal extract of dandelion, rheum officinale, loguat leaf or radix ampelopsis, and
The effect of the cellular level of the suppression MMP-1 dramatically increased compared with individual medicinal herbal extract.
The 1 type procollagen biosynthesis of especially needed suppression MMP-1 and increase in wrinkle of skin is improved.General medicinal herbs will
Or suppress MMP-1 expression in terms of effectively promote 1 type procollagen biosynthesis in terms of effectively, and due to its own
Cytotoxicity and problem can be produced in human body.Conversely, the combination of dandelion of the invention, rheum officinale, loguat leaf or radix ampelopsis
Suppress MMP-1 while extract overcomes the problem on individual medicinal herbs cytotoxicity and shows stronger and promote 1 type former
The effect of collagenous biological synthesis, therefore it can produce remarkable result as improving the cosmetic composition of wrinkle of skin.
Preparation example 1：Prepare the facial scrubs of the combined extracts containing dandelion, rheum officinale, loguat leaf and radix ampelopsis
According to the composition of table 1 such as given below, enter line program with prepare 1kg containing dandelion, rheum officinale, loguat leaf and
The facial scrubs of the combined extracts (embodiment 1) of radix ampelopsis.
The composition of the facial scrubs of the combined extracts of [table 1] containing dandelion, rheum officinale, loguat leaf and radix ampelopsis
Preparation example 2：Prepare the nutrition lotion of the combined extracts containing dandelion, rheum officinale, loguat leaf and radix ampelopsis
According to the composition of table 2 such as given below, enter line program with prepare 1 kg and contain dandelion, rheum officinale, loguat leaf
With the nutrition lotion of the combined extracts (embodiment 1) of radix ampelopsis.
The nutrition lotion of the combined extracts of [table 2] containing dandelion, rheum officinale, loguat leaf and radix ampelopsis
Claims (7)
1. a kind of cosmetic composition for improving wrinkle of skin, the cosmetic composition includes dandelion (Taraxaci
Herba), rheum officinale (Rhei Rhizoma), loguat leaf (Eriobotryae Folium) and radix ampelopsis (Ampelopsis Radix)
Combined extracts.
2. it is used to improve the cosmetic composition of wrinkle of skin as claimed in claim 1, wherein the dandelion, rheum officinale, Pi
Dandelion, the rheum officinale of 15 to 30 weight %s, 15 to 30 weights of the combined extracts of rake leaf and radix ampelopsis comprising 30 to 50 weight %
Measure the loguat leaf of % and the radix ampelopsis of 10 to 20 weight %.
3. it is used to improve the cosmetic composition of wrinkle of skin as claimed in claim 1, wherein the dandelion, rheum officinale, Pi
The combined extracts of rake leaf and radix ampelopsis are extracted by using at least one solvent selected from the group being made up of the following
And prepare：Water, with 1 to 4 alcohol and their mixture of carbon atom.
4. it is used to improve the cosmetic composition of wrinkle of skin as claimed in claim 1, wherein the wrinkle of skin is by suppression
Collagenase expression processed, increase procollagen synthesis or both and improve.
5. it is used to improve the cosmetic composition of wrinkle of skin as claimed in claim 1, wherein the cosmetic composition quilt
It is configured to selected from any one preparation in the group being made up of the following：Skin soft agent, facial scrubs, nourishing cream, massage cream,
Essence, facial mask, eye cream, washing cream, face cleaning foam, face cleaning water, facial mask, spray or pulvis.
6. a kind of method for improving wrinkle of skin, methods described include applying the dandelion of effective dose, rheum officinale, loguat leaf and
The combined extracts of radix ampelopsis.
7. the combined extracts of dandelion, rheum officinale, loguat leaf and radix ampelopsis are preparing the cosmetic combinations for improving wrinkle of skin
Purposes in thing.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2014-0104013 | 2014-08-11 | ||
| KR1020140104013A KR101753306B1 (en) | 2014-08-11 | 2014-08-11 | A cosmetic composition for improving skin winkle |
| PCT/KR2015/008197 WO2016024753A1 (en) | 2014-08-11 | 2015-08-05 | Cosmetic composition for improving skin wrinkles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106714779A true CN106714779A (en) | 2017-05-24 |
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ID=55304331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580052455.0A Pending CN106714779A (en) | 2014-08-11 | 2015-08-05 | Cosmetic composition for improving skin wrinkles |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101753306B1 (en) |
| CN (1) | CN106714779A (en) |
| WO (1) | WO2016024753A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840807A (en) * | 2019-12-14 | 2020-02-28 | 广州尚妆优品生物科技有限公司 | Wrinkle-removing composition |
| CN112501216A (en) * | 2020-12-17 | 2021-03-16 | 中国热带农业科学院热带生物技术研究所 | Method for efficiently producing tretinoin from green algae |
| CN114728032A (en) * | 2019-11-11 | 2022-07-08 | 瑞帝安有限公司 | A cosmetic composition containing Taraxacum officinale extract for improving skin |
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| KR20060044298A (en) * | 2004-03-09 | 2006-05-16 | 주식회사 한생화장품 | Cosmetic composition comprising extract of eriobotrya japonica l. for improving wrinkle |
| KR20070010216A (en) * | 2005-07-18 | 2007-01-24 | 주식회사 엘지생활건강 | Composition of skin external |
| KR20070073305A (en) * | 2006-01-04 | 2007-07-10 | 바이오스펙트럼 주식회사 | A composition for improving wrinkle on skin comprising plant extracts |
| CN103070810A (en) * | 2013-02-06 | 2013-05-01 | 成都山信药业有限公司 | Anti-skin-aging composition |
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| JP2007522259A (en) | 2004-10-20 | 2007-08-09 | ドゥサン コーポレーション | A composition containing phosphatidylserine for skin maintenance / improvement or skin barrier function enhancement |
| WO2011126295A2 (en) * | 2010-04-06 | 2011-10-13 | (주)아모레퍼시픽 | Wrapping fermentation method using medicinal leaves, and composition for external skin application using same |
| EP2753332B1 (en) | 2011-09-09 | 2017-02-15 | SK Chemicals Co., Ltd. | Mridenafil for reducing skin wrinkles |
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2014
- 2014-08-11 KR KR1020140104013A patent/KR101753306B1/en active IP Right Grant
-
2015
- 2015-08-05 WO PCT/KR2015/008197 patent/WO2016024753A1/en active Application Filing
- 2015-08-05 CN CN201580052455.0A patent/CN106714779A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20060044298A (en) * | 2004-03-09 | 2006-05-16 | 주식회사 한생화장품 | Cosmetic composition comprising extract of eriobotrya japonica l. for improving wrinkle |
| KR20070010216A (en) * | 2005-07-18 | 2007-01-24 | 주식회사 엘지생활건강 | Composition of skin external |
| KR20070073305A (en) * | 2006-01-04 | 2007-07-10 | 바이오스펙트럼 주식회사 | A composition for improving wrinkle on skin comprising plant extracts |
| CN103070810A (en) * | 2013-02-06 | 2013-05-01 | 成都山信药业有限公司 | Anti-skin-aging composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114728032A (en) * | 2019-11-11 | 2022-07-08 | 瑞帝安有限公司 | A cosmetic composition containing Taraxacum officinale extract for improving skin |
| CN110840807A (en) * | 2019-12-14 | 2020-02-28 | 广州尚妆优品生物科技有限公司 | Wrinkle-removing composition |
| CN110840807B (en) * | 2019-12-14 | 2022-06-07 | 广州尚妆优品生物科技有限公司 | Wrinkle-removing composition |
| CN112501216A (en) * | 2020-12-17 | 2021-03-16 | 中国热带农业科学院热带生物技术研究所 | Method for efficiently producing tretinoin from green algae |
| CN112501216B (en) * | 2020-12-17 | 2023-04-11 | 中国热带农业科学院热带生物技术研究所 | Method for efficiently producing tretinoin from green algae |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160019631A (en) | 2016-02-22 |
| WO2016024753A1 (en) | 2016-02-18 |
| KR101753306B1 (en) | 2017-07-04 |
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