KR20100006673A - Invention of crude composition for whitening, anti-wrinkle, anti-bacterial activity, anti-aging - Google Patents

Invention of crude composition for whitening, anti-wrinkle, anti-bacterial activity, anti-aging Download PDF

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KR20100006673A
KR20100006673A KR1020080066900A KR20080066900A KR20100006673A KR 20100006673 A KR20100006673 A KR 20100006673A KR 1020080066900 A KR1020080066900 A KR 1020080066900A KR 20080066900 A KR20080066900 A KR 20080066900A KR 20100006673 A KR20100006673 A KR 20100006673A
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whitening
wrinkle
aging
radix
cosmetic composition
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황인수
김용환
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황인수
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/44Ebenaceae (Ebony family), e.g. persimmon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

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  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Cosmetics (AREA)

Abstract

PURPOSE: A cosmetic composition containing mixture herb extract is provided to ensure high electron donation ability, SOD-like antioxidation, antibacterial, moisturization, whitening, anti-wrinkle and anti-aging effects. CONSTITUTION: A cosmetic composition for anti-oxidation, moisturization, whitening, anti-wrinkle contains persimmon leaf, ponciri Fructus, phaseoli radiati Semen, artemisiae asiaticae Herba, angelicae gigantis Radix, menthae Herba, glycyrrhizae radix, laminaria japonica, angelicae dahuricae Radix, mori Ramulus, cnidii Rhizoma, bank, houttuynia cordata, jujube, ginseng, and green tea. The mixture herb extract is isolated using water, low alcohol of 1-4 carbon atoms. Propyleneglycol, acetic acid ethyl, butyleneglycol, ether or chloride.

Description

미백, 주름개선, 향균, 항산화 효과를 나타내는 화장조성료의 발명 {invention of crude composition for whitening, anti-wrinkle, anti-bacterial activity, anti-aging}Invention of crude composition for whitening, anti-wrinkle, anti-bacterial activity, anti-aging}

본 발명은 항산화, 주름개선, 미백, 보습, 노화방지의 활성을 갖는 감잎, 지실, 녹두, 애엽, 유근피,빈랑자, 당귀, 박하, 감초, 다시마, 백지, 상지, 천궁, 은행, 어성초, 대추, 인삼, 녹차, 표고버섯을 포함하는 혼합 생약추출물을 함유하는 조성물에 관한 것이다.The present invention is an antioxidant, anti-wrinkle, whitening, moisturizing, persimmon leaf having anti-aging activity, fruit, green beans, leafy, root roots, betel nut, Angelica, mint, licorice, kelp, white paper, upper limbs, cheonggung, ginkgo, eochocho, jujube It relates to a composition containing a mixed herbal extract, ginseng, green tea, shiitake mushrooms.

피부는 나이가 들어감에 따라 주름이 증가하고 위축,퇴행되며 건조하고 거칠어진다. 털의 모주기는 변하고 눈썹, 치모 등이 길어지고, 머리털은 짧아진다. 손톱도 거칠어지고, 백색이 되고, 피부가 늘어져 만곡도 생기게 된다.As the skin ages, wrinkles increase, atrophy and degeneration, and dry and rough. The hair cycle of the hair changes, the eyebrows and pubic hair become longer, and the hair shortens. Nails become rough, white, and the skin stretches, causing curvature.

노인들의 피부 노화현상은 피하 지방층의 분로의 변화로 얼굴이나 어깨하지에서는 지방층이 소실되고 엉덩이나 복부로 침착되어 피하 지방층이 감소하고 수분이 손실되며, 탄력 섬유의 상실과 침착으로 유발된다. 피부논화의 징후는 다음과 같다. Aging of the skin in the elderly is a change in the subcutaneous fat layer shunt, the fat layer is lost in the lower face and shoulders, deposited in the buttocks or abdomen, the subcutaneous fat layer is reduced, moisture is lost, and the elastic fibers are lost and deposited. Signs of skin discussion are as follows.

1. 피부의 주름이 증가한다.1. Wrinkles of the skin increase.

2. 피부가 이완한다. 2. The skin relaxes.

3. 피부의 광택, 윤기, 매끄러룸이 저하한다.3. The gloss, gloss and smoothness of skin are reduced.

4. 피부의 살결이 거칠어지고, 피구가 흐트러진다.4. The skin texture becomes rough, and the dodgeball is disturbed.

5. 색소 침착 반점이 증가하고 사람에 따라 부분적인 탈색반점이 생긴다.5. Pigmentation spots increase and some people have partial bleaching spots.

6. 피부가 황색을 띤다.6. The skin is yellowish.

7. 두발이 감소하고, 탄력이 없어진다.7. Reduces hair and loses elasticity.

8. 두발이 벗겨진다.8. The hair is peeled off.

9. 백발이 증가한다.9. The gray hair is increased.

10. 눈썹이나 귓털이 길어진다.10. Long eyebrows or hairs.

11. 손톱이 거칠어진다. 11. Nails are rough.

피부의 노화는 내적노화와 외적노화로 분류할 수 있는데 외부적인 요인은 어느정도 조절이 가능하다고 할 수 있다. 활성산소, 자외선 및 콜라겐의 생합성 감소 등은 대표적인 주름형성의 인자로서, 이러한 외부요인들은 활성산소의 제거 및 콜라겐의 생합성의 촉진을 통해 주름을 완하하는 것으로 알려져 있다. 또한 멜라노사이트라는 기저층에 존재하는 새소세포를 작극하여 멜라닌을 합성하는데 이런 멜라닌은 기미 및 주근깨를 생성한다. Arbutin, Kojic Acid, Tropolone, Hydroquinone, melanostationedmddl등이 여성의 기미치유에 사용되고 있으나 안정선 및 효과에 있어 소비자를 만족시키지 못하여, 최근 한방자원을 이용한 천연 자원의 추출을 통하여 이러한 타이로시나제의 저해능력이 뛰어난 물질을 이용하려고 노력하고 있다. Skin aging can be classified into internal aging and external aging, and external factors can be controlled to some extent. Reducing the biosynthesis of free radicals, ultraviolet rays and collagen are representative factors for wrinkle formation, and these external factors are known to relieve wrinkles by removing free radicals and promoting collagen biosynthesis. It also synthesizes melanin by activating new small cells in the basal layer called melanocytes, which produce melasma and freckles. Arbutin, Kojic Acid, Tropolone, Hydroquinone, melanostationedmddl are used for women's blemish healing, but they do not satisfy consumers in stability and effectiveness. Recently, the inhibitory ability of tyrosinase through the extraction of natural resources using herbal resources I'm trying to use excellent materials.

항산화활성이란 생체 내 활성산소의 생성을 방지하고 세포에 회복 불가능한 손상을 야기하는 산화현상을 방지하는 활성을 말한다. 안전한 상태의 산소는 효소계, 환원대사, 화학약품, 공해물질, 광화학 반응과 같은 환경적 및 생화학적 요인 등에 의해 슈퍼옥사이드 라디칼, 하이드록실 라디칼, 과산화수소와 같은 방응성이 큰 활성산소로 전환되어 다양한 세포 구성 성분인 지질, 단백질, DNA를 산화시켜 염증을 유발하거나 여러 기관들을 손상시킨다고 알려져 있다. 활성산소의 작용은 체내 방어기구인 슈퍼옥사이드뮤타제(SOD), 카틸라아제, 퍼옥시다아제 등의 항산화성 효고 및 비타민C, E, 글루타치온등의 항산화물질의 작용에 의하여 최소화 될 수 있으나, 이러한 생체방어력에 이상이 생기거나 과도한 활성산소에 노출될 경우 이 균형이 끼어져서 각종 질병이 유발된다는 것이 보고되었다. Antioxidant activity refers to an activity that prevents the production of free radicals in vivo and prevents oxidative phenomena that cause irreparable damage to cells. Oxygen in a safe state is converted into highly reactive reactive oxygen such as superoxide radicals, hydroxyl radicals and hydrogen peroxide by various environmental and biochemical factors such as enzymes, reducing metabolism, chemicals, pollutants, and photochemical reactions. It is known to oxidize constituent lipids, proteins and DNA, causing inflammation or damaging many organs. The action of free radicals can be minimized by the action of antioxidants such as superoxide mutase (SOD), catylase, and peroxidase, and antioxidants such as vitamins C, E, and glutathione. It has been reported that in the event of abnormalities or exposure to excessive free radicals this balance is caused to cause various diseases.

본 발명은 항산화, 항균, 주름개선, 미백, 보습, 노화방지의 활성을 갖는 감잎, 지실, 녹두, 애엽, 유근피, 빈랑자, 당귀, 박하, 감초, 다시마, 상지, 천궁, 은행, 어성초, 대추, 이삼, 녹차, 표고버섯을 포함하는 혼합 생약추출물을 함유하는 안정성에 문제가 없는 비누 및 화장료 조성물을 제공하는 것이다. The present invention is an antioxidant, antibacterial, anti-wrinkle, whitening, moisturizing, persimmon leaf having anti-aging activity, fruit, green bean, young leaf, root root, betel nut, Angelica, peppermint, licorice, kelp, upper limb, Cheongung, ginkgo, Echochocho, jujube To provide a soap and cosmetic composition does not have a problem in stability, containing a mixed herbal extract containing ginseng, green tea, shiitake mushrooms.

혼합중량비는 감잎 1~20 : 지실 1~5 : 녹두 : 1~5 : 애엽 1~15 : 유근피 1~15 : 빈랑자 1~5 : 당귀 1~5 : 박하 1~5 : 감초 1~10 : 다시마 1~10 : 백지 1~5 : 상지 1~5 : 천궁 1~10 : 은행 1~5 : 어성초 1~5 : 대추 1~20 : 인삼 1~10 : 녹차 1~10 : 표고버섯 1~10으로 혼합된 것이다. Mixed weight ratio is persimmon leaf 1 ~ 20: fruit 1 ~ 5: green beans: 1 ~ 5: leaf 1 ~ 15: roots 1 ~ 15: betel nut 1 ~ 5: Angelica 1 ~ 5: mint 1 ~ 5: licorice 1 ~ 10: Kelp 1 ~ 10: White paper 1 ~ 5: Upper paper 1 ~ 5: Cheongung 1 ~ 10: Bank 1 ~ 5: Eoseongcho 1 ~ 5: Jujube 1 ~ 20: Ginseng 1 ~ 10: Green tea 1 ~ 10: Shiitake mushrooms 1 ~ 10 It is mixed with.

상기 추출물을 정제수를 포함한 물, 탄소수 1내지 4의 저급알코올 또는 프로필렌글리콜, 초산에칠, 부틸렌글리콜, 에텔, 클로로포름으로 구성된 그룹으로 부터 선택된 하나 이상의 용매에 가용한 추출물을 포한한다. The extract includes water, including purified water, lower alcohols having 1 to 4 carbon atoms or propylene glycol, ethyl acetate, butylene glycol, ether, chloroform and extracts available in one or more solvents selected from the group consisting of.

본 발명의 추출물은 감잎, 지실 녹두, 애엽, 유근피, 빈랑자, 당귀, 박하, 감초, 다시마, 백지, 상지, 천궁, 은행, 어성초, 대추, 인삼, 녹차, 표고버섯 건조중량비로 혼합한후, 추출용매로 에탄올1내지 30배, 바람직하게는 5내지 15배 부피량을 10내지 50℃ 냉침추출, 열수추출, 초음파 추출, 환류냉각 추출등의 추출방법으로 추출한 후 원심분리 및 여과, 농축하여 본 발명의 추출물을 습득한다.The extract of the present invention is mixed with persimmon leaves, fruit green beans, young leaf, root roots, betel nut, Angelica, peppermint, licorice, kelp, white paper, upper limbs, Cheongung, ginkgo, eochocho, jujube, ginseng, green tea, shiitake mushroom dry weight ratio, Ethanol 1 to 30 times, preferably 5 to 15 times the volume of the extraction solvent extracted by extraction methods such as cold extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, such as 10 to 50 ℃ centrifugation, filtration and concentration Acquire the extract of the invention.

발명의 추출방법에 의해 얻어진 추출물의 전자공여능, SOD유사활성으로 확인한 항산화효과, 향균효과, 보습, 미백, 주름개선 및 노화방지 효과가 탁월하여 노화가 진행되는 사람의 피부특성에 맞는 비누 및 화장조성물로 유용하게 사용될 수 있다. Soap and cosmetic composition suitable for skin characteristics of humans with aging progress due to excellent anti-oxidant, antibacterial, moisturizing, whitening, anti-wrinkle and anti-aging effects as confirmed by the electron donating ability and SOD-like activity of the extract obtained by the extraction method of the invention It can be usefully used.

상기 목적을 달성하기 위하여, 본 발명은 항산화, 향균, 주름개선, 보습, 미백, 노화방지 효과를 갖는 감잎, 지실, 녹두, 애엽, 유근피, 빈랑자, 당귀, 박하, 감초, 다시마, 백지, 상지, 천궁, 은행, 어성초, 대추 , 인삼, 녹차, 표고버섯을 포함하는 혼합생약 추출물을 함유하는 조성물을 제공한다. In order to achieve the above object, the present invention is an antioxidant, antibacterial, wrinkle improvement, moisturizing, whitening, persimmon leaf, fruit, green beans, green leaf, rose root, betel nut, green bean, Angelica, mint, licorice, kelp, white paper, upper limb Provided is a composition containing a mixed herbal extract comprising cheongung, ginkgo, eoseongcho, jujube, ginseng, green tea, shiitake mushrooms.

발명 추출물의 혼합중량비는 감잎 1~20 : 지실 1~5 : 녹두 : 1~5 : 애엽 1~15 : 유근피 1~15 : 빈랑자 1~5 : 당귀 1~5 : 박하 1~5 : 감초 1~10 : 다시마 1~10 : 백지 1~5 : 상지 1~5 : 천궁 1~10 : 은행 1~5 : 어성초 1~5 : 대추 1~20 : 인삼 1~10 : 녹차 1~10 : 표고버섯 1~10으로 혼합된 것이다. Mixture weight ratio of the extract of the invention is persimmon leaf 1-20: fruit 1-5: green beans: 1-5: leafy leaf 1-15: roots 1-15: betel nut 1-5: Angelica 1-5: mint 1-5: licorice 1 ~ 10: Kelp 1 ~ 10: White paper 1 ~ 5: Upper limb 1 ~ 5: Cheongung 1 ~ 10: Ginkgo 1 ~ 5: Eoseongcho 1 ~ 5: Jujube 1 ~ 20: Ginseng 1 ~ 10: Green tea 1 ~ 10: Shiitake mushroom It is mixed with 1-10.

상기 추출물을 정제수를 포함한 물, 탄소수 1내지 4의 저급알코올 또는 프로필렌글리콜, 초산에칠, 부틸렌글리콜, 에텔, 클로로포름으로 구성된 그룹으로 부터 선택된 하나 이상의 용매에 가용한 추출물을 포한한다. The extract includes water, including purified water, lower alcohols having 1 to 4 carbon atoms or propylene glycol, ethyl acetate, butylene glycol, ether, chloroform and extracts available in one or more solvents selected from the group consisting of.

본 발명의 추출물은 감잎, 지실 녹두, 애엽, 유근피, 빈랑자, 당귀, 박하, 감초, 다시마, 백지, 상지, 천궁, 은행, 어성초, 대추, 인삼, 녹차, 표고버섯 건조중량비로 혼합한후, 추출용매로 에탄올1내지 30배, 바람직하게는 5내지 15배 부피량을 10내지 50℃ 냉침추출, 열수추출, 초음파 추출, 환류냉각 추출등의 추출방법 으로 추출한 후 원심분리 및 여과, 농축하여 본 발명의 추출물을 습득한다. The extract of the present invention is mixed with persimmon leaves, fruit green beans, young leaf, root roots, betel nut, Angelica, peppermint, licorice, kelp, white paper, upper limbs, Cheongung, ginkgo, eochocho, jujube, ginseng, green tea, shiitake mushroom dry weight ratio, Ethanol 1 to 30 times, preferably 5 to 15 times the volume of the extraction solvent extracted by extraction methods such as cold extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, such as 10 to 50 ℃ centrifugation, filtration and concentration Acquire the extract of the invention.

실험재료의 준비Preparation of Experimental Materials

본실험에 사용된 약재들은 남이제약사에서 구입하였으며, 구입후 세척하여 음건후 사용하였다. The medicines used in this experiment were purchased from Nami Pharmaceuticals, washed after purchase, and used after drying.

시료 추출물의 재료Material of Sample Extract

1-1. 물추출물 제조1-1. Water extract manufacturing

본 발명의 구성 생약재들을 각각 감잎 20g : 지실5g : 녹두5g : 애엽 15g : 유근피15g : 빈랑자 5g : 박하5g : 다시마 10g : 백지 5g : 상지5g : 천궁 10g : 은행 5g : 어성초 5g : 대추 20g : 인삼 10g : 녹차 10g : 표고버섯 10g 을 혼합하여 전체 중량의 10배의 증류수를 가하여 85℃ 3시간 환류냉각 추출하여 상등액과 침전물을 분리하여 3회 반복 추출하여 물 추출물을 습득한 후, 원심분리, 여과 및 농축하여 동결건조 후 냉장실에 보관하며 본 실험의 시료로 사용하였다. Each of the constituent herbs of the present invention persimmon leaf 20g: fruit 5g: mung bean 5g: green leaf 15g: root root 15g: betel nut 5g: peppermint 5g: kelp 10g: white paper 5g: upper limb 5g: Cheongung 10g: ginkgo 5g: Eoseongcho 5g: jujube 20g: Ginseng 10g: Green tea 10g: 10g of shiitake mushrooms, distilled water of 10 times the total weight was added, reflux-cooled extraction at 85 ℃ for 3 hours to separate the supernatant and sediment three times to extract the water extract, centrifugation, After filtration and concentration, lyophilization was stored in a refrigerator compartment and used as a sample of this experiment.

도1은 본발명의 실시예에 따른 원료의 추출방식의 제조 공정도1 is a manufacturing process diagram of the extraction method of the raw material according to an embodiment of the present invention

Claims (1)

항산화, 보습, 미백, 주름개선의 효과를 갖는 감잎, 지실, 녹두, 애엽, 유근피, 빈랑자, 당귀, 박하, 감초, 다시마, 백지, 상지, 천궁, 은행, 어성초, 대추, 인삼, 녹차, 표고버섯을 포함하는 생약 추출물을 함유하는 비누 및 화장료 조성물Antioxidant, moisturizing, whitening, anti-wrinkle effect, persimmon leaf, fruit, green bean, leaf, rose root, betel nut, Angelica, peppermint, licorice, kelp, white paper, upper limb, cheonggung, ginkgo, eoseongcho, jujube, ginseng, green tea, shiitake Soap and cosmetic composition containing a herbal extract containing mushrooms
KR1020080066900A 2008-07-10 2008-07-10 Invention of crude composition for whitening, anti-wrinkle, anti-bacterial activity, anti-aging KR20100006673A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107308287A (en) * 2016-04-25 2017-11-03 西华大学 Freckle-removing and whitening composition and preparation method thereof
KR20180005054A (en) * 2016-07-05 2018-01-15 농업회사법인자연건강주식회사 Breast lift cosmetic composition containing collagen Chicken Feet
KR20180005052A (en) * 2016-07-05 2018-01-15 농업회사법인자연건강주식회사 Wrinkle cosmetic composition containing collagen to chicken feet
KR102257807B1 (en) * 2020-03-26 2021-05-28 오한선 Antibacterial cosmetic composition comprising a natural extract mixture

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107308287A (en) * 2016-04-25 2017-11-03 西华大学 Freckle-removing and whitening composition and preparation method thereof
KR20180005054A (en) * 2016-07-05 2018-01-15 농업회사법인자연건강주식회사 Breast lift cosmetic composition containing collagen Chicken Feet
KR20180005052A (en) * 2016-07-05 2018-01-15 농업회사법인자연건강주식회사 Wrinkle cosmetic composition containing collagen to chicken feet
KR102257807B1 (en) * 2020-03-26 2021-05-28 오한선 Antibacterial cosmetic composition comprising a natural extract mixture

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