CN114656378A - 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 - Google Patents
阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 Download PDFInfo
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- CN114656378A CN114656378A CN202210228264.7A CN202210228264A CN114656378A CN 114656378 A CN114656378 A CN 114656378A CN 202210228264 A CN202210228264 A CN 202210228264A CN 114656378 A CN114656378 A CN 114656378A
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
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- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337196P | 2016-05-16 | 2016-05-16 | |
| US62/337,196 | 2016-05-16 | ||
| CN201780041000.8A CN109414408B (zh) | 2016-05-16 | 2017-05-16 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
| PCT/US2017/032950 WO2017201076A1 (en) | 2016-05-16 | 2017-05-16 | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780041000.8A Division CN109414408B (zh) | 2016-05-16 | 2017-05-16 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114656378A true CN114656378A (zh) | 2022-06-24 |
Family
ID=60326218
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210228264.7A Pending CN114656378A (zh) | 2016-05-16 | 2017-05-16 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
| CN201780041000.8A Active CN109414408B (zh) | 2016-05-16 | 2017-05-16 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780041000.8A Active CN109414408B (zh) | 2016-05-16 | 2017-05-16 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US10562849B2 (enExample) |
| EP (1) | EP3458032A4 (enExample) |
| JP (3) | JP7080826B2 (enExample) |
| CN (2) | CN114656378A (enExample) |
| AU (4) | AU2017267634C1 (enExample) |
| CA (1) | CA3024129A1 (enExample) |
| WO (1) | WO2017201076A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114656378A (zh) * | 2016-05-16 | 2022-06-24 | 得克萨斯州大学系统董事会 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| JP7074843B6 (ja) | 2017-08-30 | 2023-12-26 | エコラボ ユーエスエー インコーポレイティド | 1つの疎水基と2つの同一の親水性イオン基とを有する分子、およびその組成物 |
| US11560575B2 (en) | 2017-12-29 | 2023-01-24 | Texas Tech University System | High efficient delivery of plasmid DNA into human and vertebrate primary cells in vitro and in vivo by nanocomplexes |
| WO2020047181A1 (en) | 2018-08-29 | 2020-03-05 | Ecolab Usa Inc. | Use of multiple charged ionic compounds derived from polyamines for waste water clarification |
| US11084974B2 (en) | 2018-08-29 | 2021-08-10 | Championx Usa Inc. | Use of multiple charged cationic compounds derived from polyamines for clay stabilization in oil and gas operations |
| CN116396183B (zh) * | 2018-08-29 | 2025-08-08 | 埃科莱布美国股份有限公司 | 衍生自多胺的离子化合物、其组合物和其制备方法 |
| CN112584910B (zh) | 2018-08-29 | 2023-03-14 | 埃科莱布美国股份有限公司 | 衍生自多胺的带多个电荷的离子化合物及其组合物和其作为反相破乳剂用于油气操作的用途 |
| US11058111B2 (en) | 2018-08-29 | 2021-07-13 | Ecolab Usa Inc. | Use of multiple charged cationic compounds derived from primary amines or polyamines for microbial fouling control in a water system |
| WO2020160081A1 (en) | 2019-01-29 | 2020-08-06 | Ecolab Usa Inc. | Use of cationic sugar-based compounds for microbial fouling control in a water system |
| EP4520802B1 (en) | 2019-04-16 | 2026-06-17 | Ecolab USA Inc. | Use of multiple charged cationic compounds derived from polyamines and compositions thereof for corrosion inhibition in a water system |
| KR20220044816A (ko) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법 |
| US20230203510A1 (en) | 2020-05-29 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods relating thereto |
| EP4158032A2 (en) | 2020-05-29 | 2023-04-05 | Flagship Pioneering Innovations VI, LLC | Trem compositions and methods relating thereto |
| US20230320994A1 (en) * | 2020-08-21 | 2023-10-12 | The Board Of Regents Of The University Of Texas System | Functional ionizable phospholipids |
| JP7844452B2 (ja) * | 2020-09-23 | 2026-04-13 | トランスレイト バイオ, インコーポレイテッド | Tesベースのカチオン性脂質 |
| KR20230135585A (ko) | 2020-12-23 | 2023-09-25 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 변형된 trem의 조성물 및 이의 용도 |
| MX2023011227A (es) | 2021-03-22 | 2023-12-06 | Recode Therapeutics Inc | Composiciones y metodos para administracion dirigida a celulas. |
| MX2023011243A (es) | 2021-03-23 | 2023-12-14 | Recode Therapeutics Inc | Composiciones de polinucleotidos, formulaciones relacionadas y metodos de uso de los mismos. |
| US12104181B2 (en) | 2021-03-31 | 2024-10-01 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections targeting TRIM7 |
| JP2024520834A (ja) * | 2021-06-09 | 2024-05-24 | レコード・セラピューティクス・インコーポレイテッド | ポリヌクレオチド組成物、関連する製剤及びその使用方法 |
| WO2023009547A1 (en) | 2021-07-26 | 2023-02-02 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and uses thereof |
| CN113461577B (zh) * | 2021-09-01 | 2021-12-14 | 中山大学附属第七医院(深圳) | 一种氨基脂质及其应用 |
| CN113816991B (zh) * | 2021-10-17 | 2023-12-15 | 拓新药业集团股份有限公司 | 一种氯化磷酸胆碱钙的制备方法 |
| WO2023220083A1 (en) | 2022-05-09 | 2023-11-16 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods of use for treating proliferative disorders |
| JP2025518282A (ja) * | 2022-06-03 | 2025-06-12 | バイオ-トリップ ベーフェー | 核酸送達のための多価分子に基づく脂質ナノ粒子 |
| EP4544043A1 (en) | 2022-06-22 | 2025-04-30 | Flagship Pioneering Innovations VI, LLC | Compositions of modified trems and uses thereof |
| EP4569112A1 (en) | 2022-08-12 | 2025-06-18 | Remix Therapeutics Inc. | Methods and compositions for modulating splicing at alternative splice sites |
| JP2025534494A (ja) | 2022-12-23 | 2025-10-15 | グリーン・クロス・コーポレイション | イオン化可能な脂質及びその使用 |
| WO2024216128A1 (en) | 2023-04-12 | 2024-10-17 | Flagship Pioneering Innovations Vi, Llc | Trems for use in correction of missense mutations |
| AU2024255972A1 (en) | 2023-04-12 | 2025-10-23 | Flagship Pioneering Innovations Vi, Llc | Modified trems, compositions, and related methods thereof |
| WO2024216243A2 (en) * | 2023-04-14 | 2024-10-17 | The Johns Hopkins University | Peptide-based vaccines and methods for treatment |
| EP4777488A1 (en) * | 2023-09-11 | 2026-07-22 | The Trustees of The University of Pennsylvania | Degradable, branched lipid compounds, methods of preparation thereof, lipid nanoparticles (lnps) comprising the same, and methods of use thereof |
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| BR112018073699A2 (pt) | 2019-05-07 |
| US20240174604A1 (en) | 2024-05-30 |
| AU2026202591A1 (en) | 2026-04-30 |
| US20170349543A1 (en) | 2017-12-07 |
| AU2017267634A1 (en) | 2018-11-29 |
| JP7480220B2 (ja) | 2024-05-09 |
| US11542229B2 (en) | 2023-01-03 |
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