CN114650831A - 经加工的微生物胞外囊泡 - Google Patents

经加工的微生物胞外囊泡 Download PDF

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Publication number
CN114650831A
CN114650831A CN202080042991.3A CN202080042991A CN114650831A CN 114650831 A CN114650831 A CN 114650831A CN 202080042991 A CN202080042991 A CN 202080042991A CN 114650831 A CN114650831 A CN 114650831A
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China
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pharmaceutical composition
pmev
mev
cancer
bacteria
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Pending
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CN202080042991.3A
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English (en)
Chinese (zh)
Inventor
A·巴洛克
M·博德默
B·波斯
S·M·R·卡尔顿
T·A·科尔麦克
C·J·H·达维特
L·弗兰西斯科-安德森
B·古德曼
A·伊塔诺
N·奥肯
H·波尼奇特拉
E·B·特洛伊
F·B·罗马诺-切尔纳奇
M·西佐瓦
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Epiva Biosciences Inc
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Epiva Biosciences Inc
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Publication of CN114650831A publication Critical patent/CN114650831A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080042991.3A 2019-06-11 2020-06-11 经加工的微生物胞外囊泡 Pending CN114650831A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962860049P 2019-06-11 2019-06-11
US201962860029P 2019-06-11 2019-06-11
US62/860,029 2019-06-11
US62/860,049 2019-06-11
US202062979545P 2020-02-21 2020-02-21
US62/979,545 2020-02-21
US202062991767P 2020-03-19 2020-03-19
US62/991,767 2020-03-19
PCT/US2020/037210 WO2020252149A1 (en) 2019-06-11 2020-06-11 Processed microbial extracellular vesicles

Publications (1)

Publication Number Publication Date
CN114650831A true CN114650831A (zh) 2022-06-21

Family

ID=71950732

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080042991.3A Pending CN114650831A (zh) 2019-06-11 2020-06-11 经加工的微生物胞外囊泡
CN202080043264.9A Pending CN114096262A (zh) 2019-06-11 2020-06-11 分泌的微生物胞外囊泡

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080043264.9A Pending CN114096262A (zh) 2019-06-11 2020-06-11 分泌的微生物胞外囊泡

Country Status (12)

Country Link
US (2) US20220249579A1 (https=)
EP (2) EP3982987A1 (https=)
JP (2) JP2022538765A (https=)
KR (2) KR20220020894A (https=)
CN (2) CN114650831A (https=)
AU (2) AU2020291434A1 (https=)
BR (2) BR112021024830A2 (https=)
CA (2) CA3143025A1 (https=)
CO (2) CO2022000041A2 (https=)
MX (2) MX2021015429A (https=)
TW (2) TW202128198A (https=)
WO (2) WO2020252144A1 (https=)

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JP7402805B2 (ja) * 2018-02-06 2023-12-21 エヴェロ バイオサイエンシズ，インコーポレーテッド ベイロネラ（Ｖｅｉｌｌｏｎｅｌｌａ）の細菌を使用して癌及び免疫障害を処置するための組成物及び方法
KR102286042B1 (ko) * 2019-01-09 2021-08-03 주식회사 엠디헬스케어 데이노코커스 속 세균 유래 나노소포 및 이의 용도
JP7761556B2 (ja) * 2019-09-18 2025-10-28 リサーチ ディベロップメント ファウンデーション 代謝性疾患および障害を治療するための方法およびプロバイオティック組成物
TW202214276A (zh) * 2020-06-11 2022-04-16 美商艾弗洛生物科技股份有限公司 使用ｈａｒｒｙｆｌｉｎｔｉａ ａｃｅｔｉｓｐｏｒａ治療疾病和障礙之組成物及方法
WO2021252861A1 (en) * 2020-06-11 2021-12-16 Evelo Biosciences, Inc. Compositions and methods for treating diseases and disorders using megasphaera sp
AU2021296649A1 (en) * 2020-06-22 2023-02-09 Sl Bigen, Inc. Method and composition for enhancing cancer treatment efficacy of bacteria extracellular vesicles
EP4185307A1 (en) * 2020-07-21 2023-05-31 Evelo Biosciences, Inc. Veillonella parvula strain as an oral therapy for neuroinflammatory diseases
TW202227110A (zh) * 2020-09-21 2022-07-16 美商艾弗洛生物科技股份有限公司 用棲組織普雷沃菌調節免疫反應之組成物及方法
JP2024505207A (ja) * 2021-01-26 2024-02-05 エヴェロ バイオサイエンシズ，インコーポレーテッド プレボテラ（Ｐｒｅｖｏｔｅｌｌａ）細胞外小胞調製物
WO2022178209A1 (en) * 2021-02-19 2022-08-25 Evelo Biosciences, Inc. Compositions and methods for treating metabolic diseases and disorders using christensenellaceae bacteria
WO2022221183A1 (en) * 2021-04-12 2022-10-20 Evelo Biosciences, Inc. Fournierella extracellular vesicle preparations
WO2022251166A2 (en) * 2021-05-25 2022-12-01 Evelo Biosciences, Inc. Bacterial compositions comprising soy hemoglobin
CN117440819A (zh) * 2021-06-07 2024-01-23 Md保健株式会社 包含明串珠菌属细菌来源的囊泡的用于预防或治疗炎性疾病或癌症的组合物
WO2023114300A1 (en) * 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Fournierella massiliensis bacteria extracellular vesicle preparations
WO2023114293A1 (en) * 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Extracellular vesicle assays
WO2023146843A1 (en) * 2022-01-25 2023-08-03 Evelo Biosciences, Inc. Extracellular vesicle compositions and methods of use
WO2023239728A1 (en) * 2022-06-07 2023-12-14 Evelo Biosciences, Inc. Compositions and methods of treating inflammation using prevotella histicola extracellular vesicles
JP2024167772A (ja) * 2023-05-22 2024-12-04 マイクロアルジェコーポレーション株式会社 免疫賦活用組成物及び発現誘導用組成物
CN118006515B (zh) * 2024-04-08 2024-06-18 中国农业大学 一株乳酸乳球菌及其在制备治疗牛乳腺炎的药物中的应用

Citations (5)

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EP3403670A1 (en) * 2016-01-15 2018-11-21 MD Healthcare Inc. Immunomodulator for hypersensitivity reaction to house dust mite-derived allergen
WO2019010255A1 (en) * 2017-07-05 2019-01-10 Evelo Biosciences, Inc. COMPOSITIONS AND METHODS FOR TREATING CANCER USING BIFIDOBACTERIUM ANIMALIS SSP. LACTIS
WO2019051380A1 (en) * 2017-09-08 2019-03-14 Evelo Biosciences, Inc. BACTERIAL EXTRACELLULAR (EV) VESICLES
CN109580960A (zh) * 2019-01-14 2019-04-05 周明 细胞外囊泡的分离方法、以及检测细胞外囊泡表面标志物的方法和试剂盒
WO2019099482A1 (en) * 2017-11-14 2019-05-23 Evelo Biosciences, Inc. Compositions and methods for treating disease using a blautia strain

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KR102394638B1 (ko) * 2015-09-30 2022-05-09 (주)아모레퍼시픽 유산균 유래의 세포외 소낭을 포함하는 탈모 방지 또는 육모 촉진용 조성물
TW201920648A (zh) * 2017-08-29 2019-06-01 美商艾弗洛生物科技股份有限公司 使用布勞特氏(blautia)菌株治療癌症
EP3679057A1 (en) * 2017-09-08 2020-07-15 Evelo Biosciences, Inc. Extracellular vesicles from prevotella
BR112020009133A2 (pt) * 2017-11-15 2020-10-13 Evelo Biosciences, Inc. composições e métodos de tratamento de distúrbios imunológicos usando cepas de bactérias lactococcus imunomoduladoras

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
EP3403670A1 (en) * 2016-01-15 2018-11-21 MD Healthcare Inc. Immunomodulator for hypersensitivity reaction to house dust mite-derived allergen
WO2019010255A1 (en) * 2017-07-05 2019-01-10 Evelo Biosciences, Inc. COMPOSITIONS AND METHODS FOR TREATING CANCER USING BIFIDOBACTERIUM ANIMALIS SSP. LACTIS
WO2019051380A1 (en) * 2017-09-08 2019-03-14 Evelo Biosciences, Inc. BACTERIAL EXTRACELLULAR (EV) VESICLES
WO2019099482A1 (en) * 2017-11-14 2019-05-23 Evelo Biosciences, Inc. Compositions and methods for treating disease using a blautia strain
CN109580960A (zh) * 2019-01-14 2019-04-05 周明 细胞外囊泡的分离方法、以及检测细胞外囊泡表面标志物的方法和试剂盒

Also Published As

Publication number Publication date
CA3143025A1 (en) 2020-12-17
AU2020291434A1 (en) 2022-01-06
BR112021024754A2 (pt) 2022-04-19
KR20220020893A (ko) 2022-02-21
CA3143036A1 (en) 2020-12-17
BR112021024830A2 (pt) 2022-04-12
TW202114718A (zh) 2021-04-16
EP3982987A1 (en) 2022-04-20
JP2022537684A (ja) 2022-08-29
JP2022538765A (ja) 2022-09-06
KR20220020894A (ko) 2022-02-21
CO2022000041A2 (es) 2022-01-17
US20220249579A1 (en) 2022-08-11
WO2020252149A1 (en) 2020-12-17
CN114096262A (zh) 2022-02-25
WO2020252144A1 (en) 2020-12-17
MX2021015427A (es) 2022-01-24
EP3982986A1 (en) 2022-04-20
CO2022000040A2 (es) 2022-01-17
US20220296654A1 (en) 2022-09-22
MX2021015429A (es) 2022-01-24
AU2020291003A1 (en) 2022-01-06
TW202128198A (zh) 2021-08-01

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