TW202128198A - 分泌型微生物胞外囊泡 - Google Patents

分泌型微生物胞外囊泡 Download PDF

Info

Publication number
TW202128198A
TW202128198A TW109119718A TW109119718A TW202128198A TW 202128198 A TW202128198 A TW 202128198A TW 109119718 A TW109119718 A TW 109119718A TW 109119718 A TW109119718 A TW 109119718A TW 202128198 A TW202128198 A TW 202128198A
Authority
TW
Taiwan
Prior art keywords
pharmaceutical composition
smev
bacteria
mev
cancer
Prior art date
Application number
TW109119718A
Other languages
English (en)
Chinese (zh)
Inventor
馬克 柏德默
邦多納 波西
蘇菲亞 Ｍ Ｒ 卡爾頓
泰勒 Ａ 柯麥克
克里斯多夫 Ｊ Ｈ 大衛特
安德森 路易斯 弗朗西斯科
布萊恩 古德曼
安德烈 義塔諾
霍莉 波尼奇特拉
艾琳 Ｂ 特洛伊
切爾納克 法比安 Ｂ 羅曼諾
瑪麗亞 席偌瓦
艾利希亞 巴魯克
尼哈爾 歐肯
Original Assignee
美商艾弗洛生物科技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商艾弗洛生物科技股份有限公司 filed Critical 美商艾弗洛生物科技股份有限公司
Publication of TW202128198A publication Critical patent/TW202128198A/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW109119718A 2019-06-11 2020-06-11 分泌型微生物胞外囊泡 TW202128198A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201962860049P 2019-06-11 2019-06-11
US201962860029P 2019-06-11 2019-06-11
US62/860,029 2019-06-11
US62/860,049 2019-06-11
US202062979545P 2020-02-21 2020-02-21
US62/979,545 2020-02-21
US202062991767P 2020-03-19 2020-03-19
US62/991,767 2020-03-19

Publications (1)

Publication Number Publication Date
TW202128198A true TW202128198A (zh) 2021-08-01

Family

ID=71950732

Family Applications (2)

Application Number Title Priority Date Filing Date
TW109119718A TW202128198A (zh) 2019-06-11 2020-06-11 分泌型微生物胞外囊泡
TW109119717A TW202114718A (zh) 2019-06-11 2020-06-11 經加工的微生物胞外囊泡

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW109119717A TW202114718A (zh) 2019-06-11 2020-06-11 經加工的微生物胞外囊泡

Country Status (12)

Country Link
US (2) US20220249579A1 (https=)
EP (2) EP3982987A1 (https=)
JP (2) JP2022538765A (https=)
KR (2) KR20220020894A (https=)
CN (2) CN114650831A (https=)
AU (2) AU2020291434A1 (https=)
BR (2) BR112021024830A2 (https=)
CA (2) CA3143025A1 (https=)
CO (2) CO2022000041A2 (https=)
MX (2) MX2021015429A (https=)
TW (2) TW202128198A (https=)
WO (2) WO2020252144A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7402805B2 (ja) * 2018-02-06 2023-12-21 エヴェロ バイオサイエンシズ，インコーポレーテッド ベイロネラ（Ｖｅｉｌｌｏｎｅｌｌａ）の細菌を使用して癌及び免疫障害を処置するための組成物及び方法
KR102286042B1 (ko) * 2019-01-09 2021-08-03 주식회사 엠디헬스케어 데이노코커스 속 세균 유래 나노소포 및 이의 용도
JP7761556B2 (ja) * 2019-09-18 2025-10-28 リサーチ ディベロップメント ファウンデーション 代謝性疾患および障害を治療するための方法およびプロバイオティック組成物
TW202214276A (zh) * 2020-06-11 2022-04-16 美商艾弗洛生物科技股份有限公司 使用ｈａｒｒｙｆｌｉｎｔｉａ ａｃｅｔｉｓｐｏｒａ治療疾病和障礙之組成物及方法
WO2021252861A1 (en) * 2020-06-11 2021-12-16 Evelo Biosciences, Inc. Compositions and methods for treating diseases and disorders using megasphaera sp
AU2021296649A1 (en) * 2020-06-22 2023-02-09 Sl Bigen, Inc. Method and composition for enhancing cancer treatment efficacy of bacteria extracellular vesicles
EP4185307A1 (en) * 2020-07-21 2023-05-31 Evelo Biosciences, Inc. Veillonella parvula strain as an oral therapy for neuroinflammatory diseases
TW202227110A (zh) * 2020-09-21 2022-07-16 美商艾弗洛生物科技股份有限公司 用棲組織普雷沃菌調節免疫反應之組成物及方法
JP2024505207A (ja) * 2021-01-26 2024-02-05 エヴェロ バイオサイエンシズ，インコーポレーテッド プレボテラ（Ｐｒｅｖｏｔｅｌｌａ）細胞外小胞調製物
WO2022178209A1 (en) * 2021-02-19 2022-08-25 Evelo Biosciences, Inc. Compositions and methods for treating metabolic diseases and disorders using christensenellaceae bacteria
WO2022221183A1 (en) * 2021-04-12 2022-10-20 Evelo Biosciences, Inc. Fournierella extracellular vesicle preparations
WO2022251166A2 (en) * 2021-05-25 2022-12-01 Evelo Biosciences, Inc. Bacterial compositions comprising soy hemoglobin
CN117440819A (zh) * 2021-06-07 2024-01-23 Md保健株式会社 包含明串珠菌属细菌来源的囊泡的用于预防或治疗炎性疾病或癌症的组合物
WO2023114300A1 (en) * 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Fournierella massiliensis bacteria extracellular vesicle preparations
WO2023114293A1 (en) * 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Extracellular vesicle assays
WO2023146843A1 (en) * 2022-01-25 2023-08-03 Evelo Biosciences, Inc. Extracellular vesicle compositions and methods of use
WO2023239728A1 (en) * 2022-06-07 2023-12-14 Evelo Biosciences, Inc. Compositions and methods of treating inflammation using prevotella histicola extracellular vesicles
JP2024167772A (ja) * 2023-05-22 2024-12-04 マイクロアルジェコーポレーション株式会社 免疫賦活用組成物及び発現誘導用組成物
CN118006515B (zh) * 2024-04-08 2024-06-18 中国农业大学 一株乳酸乳球菌及其在制备治疗牛乳腺炎的药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102394638B1 (ko) * 2015-09-30 2022-05-09 (주)아모레퍼시픽 유산균 유래의 세포외 소낭을 포함하는 탈모 방지 또는 육모 촉진용 조성물
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
TW201906620A (zh) * 2017-07-05 2019-02-16 美商艾弗洛生物科技股份有限公司 使用動物雙岐桿菌乳亞種 (bifidobacterium animalis ssp. lactis) 治療癌症之組合物及方法
TW201920648A (zh) * 2017-08-29 2019-06-01 美商艾弗洛生物科技股份有限公司 使用布勞特氏(blautia)菌株治療癌症
EP3679057A1 (en) * 2017-09-08 2020-07-15 Evelo Biosciences, Inc. Extracellular vesicles from prevotella
EP3678693A1 (en) * 2017-09-08 2020-07-15 Evelo Biosciences, Inc. Bacterial extracellular vesicles
CN111601610A (zh) * 2017-11-14 2020-08-28 伊夫罗生物科学公司 使用布劳特氏菌属菌株治疗疾病的组合物和方法
BR112020009133A2 (pt) * 2017-11-15 2020-10-13 Evelo Biosciences, Inc. composições e métodos de tratamento de distúrbios imunológicos usando cepas de bactérias lactococcus imunomoduladoras
CN109580960A (zh) * 2019-01-14 2019-04-05 周明 细胞外囊泡的分离方法、以及检测细胞外囊泡表面标志物的方法和试剂盒

Also Published As

Publication number Publication date
CA3143025A1 (en) 2020-12-17
AU2020291434A1 (en) 2022-01-06
BR112021024754A2 (pt) 2022-04-19
CN114650831A (zh) 2022-06-21
KR20220020893A (ko) 2022-02-21
CA3143036A1 (en) 2020-12-17
BR112021024830A2 (pt) 2022-04-12
TW202114718A (zh) 2021-04-16
EP3982987A1 (en) 2022-04-20
JP2022537684A (ja) 2022-08-29
JP2022538765A (ja) 2022-09-06
KR20220020894A (ko) 2022-02-21
CO2022000041A2 (es) 2022-01-17
US20220249579A1 (en) 2022-08-11
WO2020252149A1 (en) 2020-12-17
CN114096262A (zh) 2022-02-25
WO2020252144A1 (en) 2020-12-17
MX2021015427A (es) 2022-01-24
EP3982986A1 (en) 2022-04-20
CO2022000040A2 (es) 2022-01-17
US20220296654A1 (en) 2022-09-22
MX2021015429A (es) 2022-01-24
AU2020291003A1 (en) 2022-01-06

Similar Documents

Publication Publication Date Title
TWI814739B (zh) 細菌胞外囊泡
TWI840334B (zh) 源自普雷沃菌(prevotella)之胞外囊泡
TW202128198A (zh) 分泌型微生物胞外囊泡
CN111712260A (zh) 使用毛螺菌科细菌治疗免疫病症的组合物和方法
TW201922270A (zh) 使用免疫調節乳球菌屬 (lactococcus) 細菌菌株治療免疫病症之組合物及方法
TW202140051A (zh) 具有改善的崩散譜之固體劑型
CN115551486A (zh) 具有改善的崩解谱的固体剂型
WO2021252861A1 (en) Compositions and methods for treating diseases and disorders using megasphaera sp
TW202304486A (zh) 福涅拉氏菌屬細胞外囊泡製劑
US20230263838A1 (en) Compositions and methods for treating diseases and disorders using oscillospiraceae microbial extracellular vesicles
KR20230145050A (ko) 세포외 소포체 제제
US20230302061A1 (en) Compositions and methods for treating diseases and disorders using fournierella massiliensis
US20230218683A1 (en) Compositions and methods for treating diseases and disorders using harryflintia acetispora