CN114632131A

CN114632131A - Traditional Chinese medicine composition for softening and resolving hard mass, preparation method and application

Info

Publication number: CN114632131A
Application number: CN202210321468.5A
Authority: CN
Inventors: 刘宇寒; 刘艳春; 王瀚楠
Original assignee: Tianjin Meizhilv Biotechnology Co ltd
Current assignee: Tianjin Meizhilv Biotechnology Co ltd
Priority date: 2022-03-30
Filing date: 2022-03-30
Publication date: 2022-06-17
Anticipated expiration: 2042-03-30
Also published as: CN114632131B

Abstract

The application provides a traditional Chinese medicine composition for softening and resolving hard mass, a preparation method and application, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12-17 parts of rhizoma paridis, 12-17 parts of clove, 12-17 parts of radix curcumae, 12-17 parts of earthworm, 12-17 parts of loofah sponge, 18-22 parts of red paeony root, 18-22 parts of radix clematidis, 18-22 parts of nidus vespae and 28-32 parts of medical stone. The composition is used by matching the medicines, can regulate yin and yang, and has reasonable compatibility, so that the composition has the effects of reducing phlegm and softening hard masses, relieving swelling and resolving masses, promoting blood circulation to remove blood stasis, dredging channels and collaterals and the like, and achieves the expected treatment effect. The preparation method of the composition takes the ethanol-propylene glycol mixed solution as a solvent to extract the effective components under the condition of decoction, is simple and easy to implement, can effectively improve the dissolution rate of the effective components, and has good preparation effect.

Description

Traditional Chinese medicine composition for softening and resolving hard mass, preparation method and application

Technical Field

The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for softening and resolving hard mass, a preparation method and application.

Background

Qi, blood, essence and fluid are basic substances constituting the human body, but abnormal distribution and metabolism can lead to accumulation of pathological products, including phlegm and fluid, blood stasis, lumps, stones and the like, and thyroid nodules, lymph nodules, hyperplasia of mammary glands and the like. Among them, thyroid nodules may occur singly or multiply, and multiple nodules have a higher incidence rate than single nodules, but the single nodules have a higher incidence rate of thyroid cancer, and thyroid nodules are complicated by various thyroid diseases, such as simple goiter, thyroiditis, thyroid tumors, and the like, and have clinically good or bad scores, and the benign includes mainly nodular goiter, thyroid adenoma, and the like, while the malignant thyroid nodules mainly include thyroid cancer, thyroid lymphoma, metastatic tumors, and the like. Lymph nodes are chronic granulomatous diseases of the lymphatic reticulum system, mostly found in the skin and lymph nodes, and represent unrestrained lesions. Lymph nodes and thyroid nodules belong to the same subject, and according to the prior art, the curative effect of the medicine for treating thyroid nodules and lymph nodes is generally not ideal, the curative effect contains large uncertain factors, and meanwhile, the medicine is easy to cause large side effects after long-term administration.

The elimination of pathological products is an important link in the treatment of diseases, and the treatment method is different according to the reason for the formation of pathological products and different accumulation modes. TCM is a well-established culture and has been in history for thousands of years. Therefore, at present, a traditional Chinese medicine composition capable of effectively softening and resolving hard lumps is urgently needed to replace the traditional medicine, and has important significance.

Disclosure of Invention

The application aims to provide the traditional Chinese medicine composition for softening and resolving hard mass, which has the effects of resolving phlegm and softening hard mass, relieving swelling and resolving hard mass, promoting blood circulation to remove blood stasis, dredging channels and collaterals and the like, and has a good treatment effect.

Another objective of the present application is to provide a preparation method of the Chinese medicinal composition for softening and resolving hard mass, which is simple and easy to implement, and can effectively increase the dissolution rate of the effective components, and the preparation effect is good.

Another objective of the present application is to provide an application of the Chinese medicinal composition for softening and resolving hard mass, which has a good therapeutic effect and takes effect quickly when being applied to the preparation of medicaments for treating diseases such as hyperplasia of mammary glands, breast nodules, lobular hyperplasia, fibroma, thyroid nodules, lymphadenectasis, tonsillitis, lipoma and the like.

The technical problem to be solved by the application is solved by adopting the following technical scheme.

In a first aspect, the application provides a traditional Chinese medicine composition for softening and resolving hard mass, which comprises the following raw materials in parts by weight: 12-17 parts of rhizoma paridis, 12-17 parts of clove, 12-17 parts of radix curcumae, 12-17 parts of earthworm, 12-17 parts of loofah sponge, 18-22 parts of red paeony root, 18-22 parts of radix clematidis, 18-22 parts of nidus vespae and 28-32 parts of medical stone.

In a second aspect, the application provides a preparation method of a traditional Chinese medicine composition for softening and resolving hard mass, which mainly comprises the following steps:

weighing the raw materials according to the amount, mixing with the mixed solution I, soaking for 20-40 min, decocting with strong fire until boiling, decocting with slow fire for 1.2-1.5 h, and filtering to obtain liquid medicine I and residue I; mixing the residue I and the mixed solution II, decocting with strong fire until boiling, decocting with slow fire for 1-1.2 hr, filtering to obtain medicinal liquid II, and mixing the medicinal liquid I and medicinal liquid II to obtain Chinese medicinal composition; the first mixed solution and the second mixed solution are both prepared by mixing ethanol, propylene glycol and water.

In a third aspect, the application provides an application of a Chinese medicinal composition for softening and resolving hard mass, and an application of the Chinese medicinal composition prepared by the preparation method in preparing a medicament for treating hyperplasia of mammary glands, breast nodules, lobular hyperplasia, fibroma, thyroid nodules, lymphadenectasis, tonsillitis and/or lipoma.

The traditional Chinese medicine composition for softening and resolving hard mass and the preparation method thereof provided by the embodiment of the application have at least the following beneficial effects:

in a first aspect, the application provides a traditional Chinese medicine composition for softening and resolving hard mass, which comprises the following raw materials in parts by weight: 12-17 parts of rhizoma paridis, 12-17 parts of clove, 12-17 parts of radix curcumae, 12-17 parts of earthworm, 12-17 parts of loofah sponge, 18-22 parts of red paeony root, 18-22 parts of radix clematidis, 18-22 parts of nidus vespae and 28-32 parts of medical stone. The composition comprises rhizoma paridis and radix Paeoniae Rubra for detumescence and blood stasis dispelling, radix Curcumae, Lumbricus and radix Clematidis for promoting blood circulation, dredging collaterals and relieving pain, nidus Vespae and Maifanitum for sterilizing, relieving itching and inflammation, and flos Caryophylli for warming middle-jiao and lowering adverse qi; meanwhile, clove and clematis root are used for neutralizing the cold property of the medicine; moreover, the composition is compatible with the medicines for use, can regulate yin and yang, and has reasonable compatibility, so that the composition has the effects of resolving phlegm and softening hard masses, relieving swelling and resolving masses, promoting blood circulation and removing blood stasis, dredging channels and collaterals and the like, and achieves the expected treatment effect.

In a second aspect, the application provides a preparation method of the traditional Chinese medicine composition for softening and resolving hard lumps, the preparation method takes an ethanol-propylene glycol mixed solution as a solvent to extract effective components under the condition of decoction, and the preparation method is simple and easy to implement, can effectively improve the dissolution rate of the effective components, and has a good preparation effect.

In a third aspect, the application provides an application of a Chinese medicinal composition for softening and resolving hard mass, and when the Chinese medicinal composition is applied to preparing medicaments for treating diseases such as hyperplasia of mammary glands, breast nodules, lobular hyperplasia, fibroma, thyroid nodules, lymphadenectasis, tonsillitis, lipoma and the like, the Chinese medicinal composition has a good treatment effect and takes effect quickly.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.

Firstly, the application provides a traditional Chinese medicine composition for softening and resolving hard mass, which comprises the following raw materials in parts by weight: 12-17 parts of rhizoma paridis, 12-17 parts of clove, 12-17 parts of radix curcumae, 12-17 parts of earthworm, 12-17 parts of loofah sponge, 18-22 parts of red paeony root, 18-22 parts of radix clematidis, 18-22 parts of nidus vespae and 28-32 parts of medical stone. The specific effects of the raw materials are as follows:

rhizoma paridis: the medicine is slightly cold in nature and bitter in taste, belongs to the liver meridian, belongs to heat-clearing and detoxifying medicines classified under heat-clearing medicines, has the effects of clearing heat and detoxifying, relieving swelling and pain, cooling liver and arresting convulsion and the like, and is mainly used for treating diseases such as furuncle and carbuncle, swollen and sore throat, venomous snake bite, traumatic injury, convulsion and tetany.

Clove: warm in nature and pungent in flavor, enter stomach, spleen and kidney meridians, belong to interior-warming herbs, have the effects of warming middle energizer, lowering adverse qi, tonifying kidney and supporting yang, and are mainly used for treating diseases such as deficiency-cold of spleen and stomach, hiccup vomiting, anorexia, vomiting and diarrhea, cold pain of heart and abdomen, impotence due to kidney deficiency and the like.

Turmeric root-tuber: cold in nature, pungent and bitter in flavor, entering liver, heart and lung meridians, belonging to blood circulation promoting and stasis removing herbs, has the effects of promoting blood circulation, relieving pain, promoting qi circulation, removing scabies, clearing away heart-fire, resolving stagnation, promoting bile flow, and eliminating jaundice, and can be used for treating amenorrhea, dysmenorrhea, fever, coma, epilepsy, jaundice, dark urine, chest and abdomen distending pain, and pricking pain.

Earthworm: it is cold in nature, salty in taste, enters liver, spleen and bladder meridians, belongs to the wind-extinguishing and spasm-stopping herbs classified under liver-calming and wind-extinguishing herbs, has the effects of clearing heat and arresting convulsion, dredging collaterals, relieving asthma and inducing diuresis, and is mainly used for treating diseases such as high fever and coma, convulsive epilepsy and convulsion, arthralgia, limb numbness, hemiplegia, cough due to lung heat, oliguria and edema, hypertension and the like.

Loofah sponge: neutral in nature and sweet in taste, belongs to blood circulation promoting and pain relieving medicines classified under blood circulation promoting and blood stasis removing medicines, has the effects of promoting blood circulation, dredging collaterals and dispelling wind, and is mainly used for treating chest and hypochondrium pain, abdominal pain, lumbago, testicular pain, female menstrual pain, galactostasis, lung heat cough, hemorrhoids and fistula, metrorrhagia and metrostaxis and other diseases caused by qi and blood stasis and obstruction of channels and collaterals.

Red peony root: the traditional Chinese medicine composition is slightly cold in nature and bitter in taste, enters liver and spleen channels, belongs to heat-clearing and blood-cooling medicines classified under heat-clearing medicines, has the effects of clearing heat, cooling blood, removing stasis and relieving pain, and is mainly used for treating diseases such as warm-toxicity ecchymosis, hematemesis, epistaxis, eye-nourishing swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, traumatic injury, carbuncle, swelling, sore and ulcer and the like.

Clematis root: warm in nature, pungent in flavor and salty in taste, enters bladder meridian, belongs to wind-damp-dispelling and cold-dispelling medicines classified under wind-damp-dispelling diseases, has the effects of dispelling wind, eliminating dampness, dredging collaterals and relieving pain, and is used for relieving pain, resisting malaria, reducing blood sugar, benefiting gallbladder, enhancing esophageal peristalsis, softening fishbone spur, relaxing pharynx, esophagus and smooth intestine and the like.

Honeycomb exposing: has mild nature and sweet taste, belongs to the stomach channel, belongs to the insecticidal antipruritic, has the efficacies of dispelling wind, counteracting toxic substance, killing parasites and relieving pain, and is used for treating toothache due to decayed tooth, sore and ulcer pyogenic infections, acute mastitis, scrofula, intractable tinea, fungal infection of hand and foot, and the like.

Medical stone: maifanitum is a natural silicate mineral, has warm nature and sweet taste, and can be used for treating acne, freckle, summer speckle, miliaria, bromhidrosis, sweaty sore, herpes zoster and dermatoses due to suppurative bacteria.

In conclusion, the composition uses rhizoma paridis and radix paeoniae rubra for detumescence and stasis dissipation, uses radix curcumae, earthworm and radix clematidis for promoting blood circulation, dredging collaterals and relieving pain, uses nidus vespae and medical stone for sterilization, itching relieving and inflammation diminishing, and uses clove for warming middle-jiao and lowering adverse qi; meanwhile, clove and clematis root are used for neutralizing the cold property of the medicine; moreover, the composition is compatible with the medicines for use, can regulate yin and yang, and has reasonable compatibility, so that the composition has the effects of resolving phlegm and softening hard masses, relieving swelling and resolving masses, promoting blood circulation and removing blood stasis, dredging channels and collaterals and the like, and achieves the expected treatment effect.

In the application, the composition comprises the following raw materials in parts by weight: 15 parts of rhizoma paridis, 15 parts of clove, 15 parts of radix curcumae, 15 parts of earthworm, 15 parts of loofah sponge, 20 parts of red paeony root, 20 parts of radix clematidis, 20 parts of nidus vespae and 30 parts of medical stone. The proportion and the dosage of the raw materials are the optimal dosage, at the moment, the dosage of the medicine is moderate, and the applicability of the composition can be improved while the treatment effect is not reduced.

Secondly, the application provides a preparation method of the traditional Chinese medicine composition for softening and resolving hard mass, which mainly comprises the following steps:

Specifically, the first mixed solution and the second mixed solution are both prepared by mixing ethanol, propylene glycol and water, and are used as solvents, so that ethanol molecules can quickly penetrate cell walls, effective components can be quickly dissolved into the solutions, and then the effective components are delayed from being hydrolyzed in the mixed solution containing the propylene glycol, and the stability of the effective components is enhanced.

In the application, the volume ratio of the water, the ethanol and the propylene glycol in the first mixed solution is (295-305) to 1:1, and the volume ratio of the water, the ethanol and the propylene glycol in the second mixed solution is (495-505) to 1: 1.

In order to improve the wall breaking effect of the traditional Chinese medicine raw materials, ultrasonic treatment is carried out in the soaking process, and the ultrasonic frequency is 35kHz-45 kHz.

In the application, the traditional Chinese medicine composition can be prepared into paste, so that the effect of convenient use is achieved, and the convenience of the composition are effectively improved. The preparation method of the ointment mainly comprises the following steps:

concentrating the Chinese medicinal composition, mixing with adjuvants, homogenizing, emulsifying, and making into unguent; the raw and auxiliary materials comprise petrolatum, polydimethylsiloxane, lanolin, glycerin, jojoba fat and silk amino acid.

The petrolatum is also called vaseline as excipient, so that the traditional Chinese medicine composition can form paste for external use. When the polydimethylsiloxane is used as a raw material and an auxiliary material, the interfacial tension between an oil phase and a water phase can be reduced, so that the emulsifying effect is better, and the preparation effect of the cream is better. Meanwhile, the polydimethylsiloxane has a better defoaming effect, so that the cream is more delicate in texture and better in using effect. Lanolin as raw material and auxiliary material has good emulsifying effect, and can promote percutaneous absorption of ointment. In the application, jojoba grease is as the oil agent, can make the cream have the effect of moisturizing the skin and moisturizing, makes the cream be difficult for the oxidation simultaneously, and life is longer. The silk amino acid has good skin care effect, and enhances the use value of the traditional Chinese medicine composition.

In the application, the paste is specifically prepared as follows:

heating jojoba fat in water bath to 75-85 deg.C, sequentially mixing with lanolin and Chinese medicinal composition to obtain emulsified product, mixing with adjuvants except jojoba fat and lanolin, and making into unguent. The features and properties of the present application are described in further detail below with reference to examples.

The jojoba grease and the traditional Chinese medicine composition can be fully emulsified through the preparation method, and a stable and fine emulsified product is formed, so that the using effect of the paste is better.

In the application, the traditional Chinese medicine composition is heated to 90-100 ℃ before being mixed with the jojoba fat, and then is mixed to prepare an emulsified product.

In the application, when lanolin and jojoba fat are mixed, sodium lauryl sulfate is added, and after stirring and mixing, the traditional Chinese medicine composition is added.

It should be noted that the above Chinese medicinal composition can be made into spray or other preparations in addition to ointment.

The features and properties of the present application are described in further detail below with reference to examples.

Example 1

The embodiment aims to provide a traditional Chinese medicine composition for softening and resolving hard mass, which comprises the following raw materials:

15g of rhizoma paridis, 15g of clove, 15g of radix curcumae, 15g of earthworm, 15g of loofah sponge, 20g of red paeony root, 20g of radix clematidis, 20g of nidus vespae and 30g of medical stone.

The preparation method of the composition comprises the following steps:

weighing the raw materials according to the amount, mixing with the mixed solution I, soaking for 30min, decocting with strong fire to boil, decocting with slow fire for 1.3h-1.4h, and filtering with 600 mesh gauze to obtain liquid medicine I and residue I; mixing the first medicinal residue with the second mixed solution, decocting with strong fire until boiling, decocting with slow fire for 1-1.2 hr, filtering with 600 mesh gauze to obtain second medicinal liquid, and mixing the first medicinal liquid and the second medicinal liquid to obtain the Chinese medicinal composition; the mixed solution I and the mixed solution II are both prepared by mixing ethanol, propylene glycol and water, the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution I is 300:1:1, and the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution II is 500:1: 1.

Example 2

The preparation method of the composition comprises the following steps:

weighing the raw materials according to the amount, mixing with the mixed solution I, soaking for 30min, performing ultrasonic treatment at a frequency of 40kHz in the soaking process, decocting with strong fire until the mixture is boiled, decocting with slow fire for 1.3-1.4 h, and filtering with 600-mesh gauze to obtain a first liquid medicine and a first residue medicine; mixing the first medicinal residue with the second mixed solution, decocting with strong fire until boiling, decocting with slow fire for 1-1.2 hr, filtering with 600 mesh gauze to obtain second medicinal liquid, and mixing the first medicinal liquid and the second medicinal liquid to obtain the Chinese medicinal composition; the mixed solution I and the mixed solution II are both prepared by mixing ethanol, propylene glycol and water, the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution I is 300:1:1, and the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution II is 500:1: 1.

Example 3

The preparation method of the composition comprises the following steps:

Then, after concentrating the traditional Chinese medicine composition, directly mixing the traditional Chinese medicine composition with raw and auxiliary materials, and homogenizing and emulsifying under the condition of 0.2MPa to obtain paste; the raw and auxiliary materials comprise petrolatum, polydimethylsiloxane, lanolin, glycerin, jojoba fat and silk amino acid.

Example 4

The preparation method of the composition comprises the following steps:

Then, heating the jojoba fat to 80 ℃ in a water bath, sequentially mixing with lanolin and the concentrated traditional Chinese medicine composition (heating the traditional Chinese medicine composition to 95 ℃) to prepare an emulsified product, mixing the emulsified product with raw and auxiliary materials except the jojoba fat and the lanolin, homogenizing and emulsifying under the condition of 0.2MPa to prepare an ointment; the raw and auxiliary materials comprise petrolatum, polydimethylsiloxane, lanolin, glycerin, jojoba fat and silk amino acid.

Example 5

12g of rhizoma paridis, 12g of clove, 12g of radix curcumae, 12g of earthworm, 12g of loofah sponge, 18g of red paeony root, 18g of radix clematidis, 18g of nidus vespae and 28g of medical stone.

The preparation method of the composition comprises the following steps:

weighing the raw materials according to the amount, mixing with the mixed solution I, soaking for 20min, performing ultrasonic treatment at a frequency of 35kHz in the soaking process, decocting with strong fire until the mixture is boiled, decocting with slow fire for 1.2-1.25 h, and filtering with 600-mesh gauze to obtain a first liquid medicine and a first residue medicine; mixing the first medicinal residue with the second mixed solution, decocting with strong fire until boiling, decocting with slow fire for 1-1.2 hr, filtering with 600 mesh gauze to obtain second medicinal liquid, and mixing the first medicinal liquid and the second medicinal liquid to obtain the Chinese medicinal composition; the mixed solution I and the mixed solution II are both prepared by mixing ethanol, propylene glycol and water, the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution I is 295:1:1, and the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution II is 495:1: 1.

Then, heating the jojoba fat to 75 ℃ in a water bath, sequentially mixing with lanolin (and adding sodium lauryl sulfate when adding the lanolin) and the concentrated traditional Chinese medicine composition (heating the traditional Chinese medicine composition to 90 ℃) to prepare an emulsified product, mixing the emulsified product with raw and auxiliary materials except the jojoba fat and the lanolin, homogenizing and emulsifying under the condition of 0.2MPa to prepare an ointment; the raw and auxiliary materials comprise petrolatum, polydimethylsiloxane, lanolin, glycerin, jojoba fat and silk amino acid.

Example 6

17g of rhizoma paridis, 17g of clove, 17g of radix curcumae, 17g of earthworm, 17g of loofah sponge, 22g of red paeony root, 22g of radix clematidis, 22g of nidus vespae and 32g of medical stone.

The preparation method of the composition comprises the following steps:

weighing the raw materials according to the amount, mixing with the mixed solution I, soaking for 40min, performing ultrasonic treatment with the ultrasonic frequency of 45kHz in the soaking process, decocting with strong fire until boiling, decocting with slow fire for 1.45-1.5 h, and filtering with 600-mesh gauze to obtain a first liquid medicine and a first residue; mixing the first medicinal residue with the second mixed solution, decocting with strong fire until boiling, decocting with slow fire for 1-1.2 hr, filtering with 600 mesh gauze to obtain second medicinal liquid, and mixing the first medicinal liquid and the second medicinal liquid to obtain the Chinese medicinal composition; the mixed solution I and the mixed solution II are both prepared by mixing ethanol, propylene glycol and water, the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution I is 305:1:1, and the volume ratio of the water to the ethanol to the propylene glycol in the mixed solution II is 505:1: 1.

Then, heating the jojoba fat to 85 ℃ in a water bath, sequentially mixing with lanolin (and adding sodium lauryl sulfate when adding the lanolin) and the concentrated traditional Chinese medicine composition (heating the traditional Chinese medicine composition to 100 ℃) to prepare an emulsified product, mixing the emulsified product with raw and auxiliary materials except the jojoba fat and the lanolin, homogenizing and emulsifying under the condition of 0.2MPa to prepare an ointment; the raw and auxiliary materials comprise petrolatum, polydimethylsiloxane, lanolin, glycerin, jojoba fat and silk amino acid.

Examples of effects

122 volunteers with mammary gland hyperplasia were recruited, aged 25-48 years, with a mean age (37.12 ± 3.22) years, with a course of 1-5 years, and a mean course of 2.8 years. The patients are classified into the groups from example 1 to example 4 according to symptoms, and the general data comparison difference of the patients from the groups from example 1 to example 4 is not statistically significant (P > 0.05) and is comparable;

volunteers included criteria: the traditional Chinese medicine diagnoses hyperplasia of mammary glands in Western medicine, the syndrome differentiation of the traditional Chinese medicine accords with qi stagnation and blood stasis, and the age is 20-55 years old;

volunteer exclusion criteria: (1) hyperplasia of mammary glands in males; (2) gestation or lactation; (3) a benign or malignant tumor of the breast; (4) mammary swelling and pain caused by other reasons; (5) poor compliance; (6) age greater than 55 years or menopause; (7) it is not fit for the syndrome of TCM.

The using method comprises the following steps: the composition prepared in example 1 to example 3 was externally applied to the affected part, and the ointment prepared in example 4 was externally applied to the affected part once a day in the morning and evening. In addition, the dosage of the Chinese medicinal composition in the embodiment 1 to the embodiment 4 is the same.

The judgment of the curative effect by referring to the clinical research guideline of new traditional Chinese medicine is as follows:

the effect is shown: the clinical symptoms are obviously improved, and the symptom score is obviously changed; the method has the following advantages: the clinical symptoms are not obviously improved, and the integral change of the syndrome is not obvious; and (4) invalidation: clinical symptoms are not relieved, and the integral change of symptoms is meaningless.

TABLE 1 therapeutic results

Group of	Example number (human)	Show effect	Is effective	Invalidation	Effective rate%
						EXAMPLE 1 group	30	15	7	8	73
EXAMPLE 2 group	30	15	9	6	80
						EXAMPLE 3 group	30	14	12	4	86.6
EXAMPLE 4 group	32	18	13	1	96.8

As can be seen from the above table, the Chinese medicinal composition has obvious effect after being prepared into paste for external use. Moreover, when the traditional Chinese medicine composition is used for 2 to 3 days, the symptoms are obviously relieved, so that the traditional Chinese medicine composition has the advantage of quick response and higher use value.

In addition, the patient with the nodules and the tumors can be treated by the traditional Chinese medicine composition, the softening effect can be obviously achieved within 3-5 days in the treatment process, and the nodules and the tumors gradually disperse until the nodules and the tumors are regressed after the traditional Chinese medicine composition is used for about one week.

In summary, the present application provides a hard lump softening and resolving traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 12-17 parts of rhizoma paridis, 12-17 parts of clove, 12-17 parts of radix curcumae, 12-17 parts of earthworm, 12-17 parts of loofah sponge, 18-22 parts of red paeony root, 18-22 parts of radix clematidis, 18-22 parts of nidus vespae and 28-32 parts of medical stone. The composition comprises rhizoma paridis and radix Paeoniae Rubra for detumescence and blood stasis dispelling, radix Curcumae, Lumbricus and radix Clematidis for promoting blood circulation, dredging collaterals and relieving pain, nidus Vespae and Maifanitum for sterilizing, relieving itching and inflammation, and flos Caryophylli for warming middle-jiao and lowering adverse qi; meanwhile, clove and clematis root are used for neutralizing the cold property of the medicine; moreover, the composition is compatible with the medicines for use, can regulate yin and yang, and has reasonable compatibility, so that the composition has the effects of resolving phlegm and softening hard masses, relieving swelling and resolving masses, promoting blood circulation and removing blood stasis, dredging channels and collaterals and the like, and achieves the expected treatment effect. Secondly, the application provides a preparation method of the traditional Chinese medicine composition for softening and resolving hard lumps, the preparation method takes the ethanol-propylene glycol mixed solution as a solvent to extract the effective components under the condition of decoction, and the preparation method is simple and easy to implement, can effectively improve the dissolution rate of the effective components, and has a good preparation effect. Thirdly, the application provides the application of the Chinese medicinal composition for softening and resolving hard mass, and when the Chinese medicinal composition is applied to the preparation of medicaments for treating diseases such as hyperplasia of mammary glands, breast nodules, lobular hyperplasia, fibroma, thyroid nodules, lymphadenectasis, tonsillitis, lipoma and the like, the Chinese medicinal composition has a good treatment effect and takes effect quickly.

The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Claims

1. The traditional Chinese medicine composition for softening and resolving hard mass is characterized by comprising the following raw materials in parts by weight:

12-17 parts of rhizoma paridis, 12-17 parts of clove, 12-17 parts of radix curcumae, 12-17 parts of earthworm, 12-17 parts of loofah sponge, 18-22 parts of red paeony root, 18-22 parts of radix clematidis, 18-22 parts of nidus vespae and 28-32 parts of medical stone.

2. The traditional Chinese medicine composition for softening and resolving hard mass according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15 parts of rhizoma paridis, 15 parts of clove, 15 parts of radix curcumae, 15 parts of earthworm, 15 parts of loofah sponge, 20 parts of red paeony root, 20 parts of radix clematidis, 20 parts of nidus vespae and 30 parts of medical stone.

3. A method for preparing the hard lump-softening and stagnation-dissipating traditional Chinese medicine composition as claimed in claim 1 or 2, which comprises the following steps:

weighing the raw materials according to the amount, mixing with the mixed solution I, soaking for 20-40 min, decocting with strong fire until boiling, decocting with slow fire for 1.2-1.5 h, and filtering to obtain liquid medicine I and residue I; mixing the first decoction dregs with the second mixed solution, decocting with strong fire until the mixture is boiled, then decocting with slow fire for 1-1.2 h, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain the traditional Chinese medicine composition; the first mixed solution and the second mixed solution are both prepared by mixing ethanol, propylene glycol and water.

4. The method as claimed in claim 3, wherein the volume ratio of water, ethanol and propylene glycol in the first mixed solution is (295) to 1:1, and the volume ratio of water, ethanol and propylene glycol in the second mixed solution is (495) to 1: 1.

5. The method for preparing a Chinese medicinal composition for softening and resolving hard mass as claimed in claim 3, wherein ultrasound is performed during soaking, and the frequency of the ultrasound is 35kHz-45 kHz.

6. The method for preparing the Chinese medicinal composition for softening and resolving hard mass according to any one of claims 3 to 5, wherein the Chinese medicinal composition is concentrated, mixed with raw and auxiliary materials, homogenized and emulsified to prepare an ointment; the raw and auxiliary materials comprise petrolatum, polydimethylsiloxane, lanolin, glycerin, jojoba fat and silk amino acid.

7. The method for preparing a Chinese medicinal composition for softening and resolving hard mass as claimed in claim 6, wherein the jojoba lipid is heated in water bath to 75-85 deg.C, and then sequentially mixed with the lanolin and the Chinese medicinal composition to obtain an emulsified product, and the emulsified product is further mixed with raw and auxiliary materials except for the jojoba lipid and the lanolin to obtain the ointment.

8. The method for preparing a Chinese medicinal composition for softening and resolving hard mass as claimed in claim 7, wherein the emulsion is prepared by heating the composition to 90-100 ℃ before mixing with jojoba lipid, and mixing.

9. The method for preparing a Chinese medicinal composition for softening and resolving hard mass as claimed in claim 7, wherein the lanolin is mixed with jojoba fat, sodium lauryl sulfate is added, and the mixture is stirred and mixed, and then the Chinese medicinal composition is added.

10. The application of the Chinese medicinal composition for softening and resolving hard lumps is characterized in that the Chinese medicinal composition for softening and resolving hard lumps, which is prepared according to any one of claims 3 to 9, is applied to the preparation of medicaments for treating hyperplasia of mammary glands, breast nodules, lobular hyperplasia, fibroma, thyroid nodules, lymphadenectasis, tonsillitis and/or lipoma.