CN110393781B - Pure traditional Chinese medicine preparation for treating thyroid nodule and preparation method thereof - Google Patents
Pure traditional Chinese medicine preparation for treating thyroid nodule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pure traditional Chinese medicine preparation for treating thyroid nodule, which comprises the following components in percentage by weight and volume: discloses a pure traditional Chinese medicine preparation for treating thyroid nodule, which comprises the following components in percentage by weight and volume: 15-30 parts of selfheal, 15-30 parts of dandelion, 10-20 parts of fructus forsythiae, 10-20 parts of rhizoma bolbostemmae, 30-60 parts of raw oyster, 10-20 parts of ternate buttercup root, 15-20 parts of spina gleditsiae, 10-20 parts of radix curcumae, 20-30 parts of raw turtle shell, 5-10 parts of edible tulip and 10-15 parts of semiaquilegia adoxoides. The materials selected for treating thyroid nodules are traditional Chinese medicinal materials, have no toxic or side effect, are easily available in medicine sources, are low in medicine cost, do not cause economic burden to patients, and have the effects of resolving carbuncles, dissipating stagnation, promoting blood circulation, removing blood stasis and reducing phlegm by combining the medicines, so that the size of the thyroid nodules can be remarkably reduced, clinical symptoms of the patients can be eliminated, and pain can be relieved.
Description
The technical field is as follows:
the invention relates to a pure traditional Chinese medicine preparation for treating thyroid nodule and a preparation method thereof.
Background art:
thyroid nodules refer to lumps in the thyroid, can move up and down along with the thyroid along with swallowing actions, most nodules are benign nodules, the disease incidence rate is very high, female patients are common, the causes are very complicated and mainly include iodine deficiency or high-iodine diet, environmental factors, gene factors, emotional factors, excessive living pressure and the like, the disease history is often long, the disease gradually grows up unconsciously, multiple thyroid diseases such as thyroid degeneration, inflammation, autoimmunity, neoplasms and the like can be clinically expressed as nodules, thyroid nodules can be singly or frequently generated, the incidence rate of thyroid cancer caused by singly generating nodules is high, except that the nodules are large and compression symptoms cause dyspnea, dysphagia, hoarseness tendency or hyperthyroidism symptom should be treated by operation, other thyroid nodules can be treated conservatively, and the current clinical treatment aiming at the thyroid nodules, most western medicines adopt hormone medicines or operation treatment, but the postoperative recurrence rate is high, the treatment effect is not ideal, the cost is high, and the economic burden and the mental burden of patients are increased.
Thyroid nodules belong to the category of 'goiter' in traditional Chinese medicine, i think that the thyroid nodules are an aggregate of 'goiter' and 'scrofula', and the disease is mainly related to dietary water and soil inadaptation, emotional internal injury and constitutional factors.
The invention content is as follows:
in order to solve the defects of the prior art, the inventor invents a pure traditional Chinese medicine preparation for treating thyroid nodules through years of exploration and clinical research, has no toxic or side effect on bodies, avoids the pain and economic burden of surgical treatment, can obviously reduce the nodules, has obvious effect and is convenient for patients to accept.
The invention provides the following technical scheme:
a pure traditional Chinese medicine preparation for treating thyroid nodule comprises the following components in parts by weight: 15-30 parts of selfheal, 15-30 parts of dandelion, 10-20 parts of fructus forsythiae, 10-20 parts of rhizoma bolbostemmae, 30-60 parts of raw oyster, 10-20 parts of ternate buttercup root, 15-20 parts of spina gleditsiae, 10-20 parts of radix curcumae, 20-30 parts of raw turtle shell, 5-10 parts of edible tulip and 10-15 parts of semiaquilegia adoxoides.
As an optimization scheme:
the traditional Chinese medicine preparation is composed of the following important components in parts by weight: 20-25 parts of selfheal, 20-25 parts of dandelion, 10-15 parts of fructus forsythiae, 12-18 parts of rhizoma bolbostemmae, 40-50 parts of raw oyster, 12-18 parts of ternate buttercup root, 15-18 parts of spina gleditsiae, 10-15 parts of radix curcumae, 25-28 parts of raw turtle shell, 5-8 parts of edible tulip and 10-12 parts of semiaquilegia adoxoides.
As an optimization scheme:
the traditional Chinese medicine preparation is composed of the following important components in parts by weight: 25 parts of selfheal, 25 parts of dandelion, 12 parts of fructus forsythiae, 15 parts of rhizoma bolbostemmae, 45 parts of raw oyster, 15 parts of radix ranunculi ternati, 16 parts of spina gleditsiae, 12 parts of radix curcumae, 25 parts of raw turtle shell, 8 parts of edible tulip and 12 parts of semiaquilegia adoxoides.
The pharmacological analysis of the raw materials of the traditional Chinese medicine of the invention is as follows:
selfheal: pungent and bitter in flavor and cold in nature. It enters liver and gallbladder meridians. Has effects of clearing liver fire, resolving stagnation, and calming liver-yang. It is commonly used for conjunctival congestion, swelling and pain, nyctalopia, scrofula, goiter, vertigo and headache. Modern research shows that: the prunella vulgaris can regulate the immune function, reduce blood sugar, lower blood pressure, resist tumors and resist pathogenic microorganisms.
Dandelion: bitter in taste, sweet and cold in nature. It enters liver and stomach meridians. Has the effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogenic accumulation, removing dampness, and treating stranguria. It is commonly used for scrofula, lymphadenitis, mastitis, tonsillitis, furunculosis and sore. Modern research shows that: the herba Taraxaci has effects of resisting pathogenic microorganism, resisting tumor, and resisting ulcer.
Fructus forsythiae: bitter taste, slightly cold nature, heart, lung and small intestine meridians entered. Has the effects of clearing away heat and toxic materials, relieving swelling, and dispersing pathogenic accumulation. It is commonly used for scrofula, abscess and deep rooted carbuncle, acute mastitis, etc. Modern research shows that: fructus forsythiae has antimicrobial, liver injury resisting, and antiinflammatory effects.
Paniculate Bolbostemma rhizome: bitter in taste, cool in nature, entering lung and spleen meridians. Has the effects of clearing heat, eliminating phlegm, resolving masses and removing toxic substances. It is commonly used to treat scrofula, subcutaneous nodule, sores, ulcers, swelling, acute mastitis, etc. Modern clinical studies: the rhizoma Bolbostematis has antitumor, antiviral, and antiinflammatory effects.
Raw oyster shells: salty in taste, slightly cold in nature, entering liver, gallbladder and kidney meridians. Has the effects of tranquilizing mind, suppressing yang hyperactivity, nourishing yin, softening and resolving hard mass. It is commonly used for vertigo, tinnitus, scrofula, subcutaneous nodule, mass, etc. Modern research shows that: the Concha Ostreae has effects of tranquilizing, locally narcotizing, inhibiting nerve and muscle excitation, and enhancing immunity.
Radix ranunculi ternati: it is pungent and sweet in flavor, warm in nature and enters liver and lung meridians. Has the effects of resolving hard mass and relieving swelling. It is commonly used to treat tuberculosis of cervical lymph nodes, scrofula, pharyngolaryngitis, pulmonary tuberculosis, etc. Modern research shows that: radix Ranunculi Ternati has effects of resisting tumor and relieving swelling.
Spina gleditsiae: pungent in flavor and warm in nature, it enters liver and stomach meridians. Has the functions of eliminating swelling, expelling toxin, expelling pus and killing pests. It is commonly used to treat sore, ulcer, eczema, mastitis, etc. Modern research shows that: spina Gleditsiae has the effects of dispelling wind, warming and dredging, inhibiting inflammation, relieving swelling and resolving hard mass.
Turmeric root-tuber: pungent and bitter in flavor, cold in nature, entering liver, heart and lung meridians. Has effects of promoting blood circulation, activating qi-flowing, cooling blood, clearing heart fire, dispersing stagnated liver qi, and relieving qi stagnation. It is commonly used to treat various pains in chest, abdomen and hypochondrium, cold accumulation, vertigo, and adverse effects of neck and throat. Modern research shows that: radix Curcumae has the effects of eliminating nodular goiter and thyroiditis.
Fresh turtle shell: it is slightly cold in nature and enters liver and kidney meridians. Has effects in nourishing yin, suppressing yang hyperactivity, softening and resolving hard mass. It is indicated for abdominal mass, amenorrhea, fever due to yin deficiency. Modern research shows that; carapax Trionycis has antitumor and abdominal mass eliminating effects.
And (3) semiaquilegia root: sweet in flavor and cold in nature, entering lung, spleen and kidney meridians. Has repercussive, toxic materials clearing away, and diuretic effects. It is often used to treat scrofula, swelling and irregular menstruation.
The invention has the advantages that:
the medicament has the advantages of pure natural Chinese medicinal raw materials, reasonable compatibility, accordance with the dialectical theory of the traditional Chinese medicine, having the effects of soothing liver, regulating qi, eliminating carbuncle, dissipating stagnation, promoting blood circulation, dissipating blood stasis and reducing phlegm, having obvious effect on treating thyroid nodules, effectively reducing the size of the thyroid nodules, being rigorous in composition, safe, free of toxic and side effects, convenient for patients to take, convenient to carry, easily available in medicine sources, low in cost and the like, and being capable of relieving the burden and pain of the patients and achieving the purpose of treating both principal and secondary aspects of diseases.
The preparation method comprises the following steps:
cleaning the traditional Chinese medicine raw materials according to parts by weight, draining, drying at 55-70 ℃ for 2-4h, respectively processing the dried raw materials, pulverizing into powder, sieving with a 80-100 mesh sieve, uniformly mixing with a stirrer, and preparing into pills or powder.
The taking method comprises the following steps: the preparation is administered at a dose of 10g for 2 times a day 30 min after meals, and 2 months is a treatment course.
Clinical data:
1. case selection:
120 outpatients are randomly divided into a treatment group and a control group, 60 treatment groups comprise 20 males and 40 females with the age of 25-65 years, 60 control groups comprise 20 males and 40 females with the age of 25-65 years, and two groups of patients with the treatment group and the control group have the same disease course and the severity of symptoms and are basically consistent and comparable.
2. Diagnostic criteria:
the main performance is as follows: patients with thyroid benign nodules often have no obvious clinical symptoms, some patients are only found in physical examination, some patients can have neck swelling, neck frontal region oppression and discomfort, or symptoms of hoarseness and dysphagia, and the patients are often poor in mood, dizziness, chest distress, anxiety, dysphoria, irritability and the like.
3. The treatment method comprises the following steps:
the Chinese medicinal preparation provided by the invention is taken by treatment groups, powder or pills are taken twice according to the taking method, the powder or pills are taken once in the morning and at night, and two months are a treatment course.
The control group was administered a small dose of levothyroxine.
4. The curative effect standard is as follows:
and (3) curing: after treatment, the discomfort symptom completely disappeared, and thyroid gland normality was checked.
The effect is as follows: after treatment, discomfort was reduced and thyroid nodules were examined for shrinkage.
And (4) invalidation: thyroid nodule size did not change after treatment.
5. The treatment results are as follows:
in a treatment group, 55 cases are cured, 3 cases are effective, 2 cases are ineffective, and the total effective rate is 96.7%; in the control group, 20 cases are cured, 20 cases are effective, 2 cases are ineffective, and the total effective rate is 67%.
The treatment results show that the treatment effect of the treatment group is obviously better than that of the control group, the illness state can be well controlled, the treatment time is short, and the cost is low.
Typical cases are:
case 1: a certain king is a woman in age of 45, the disease course is three years, and the patient feels uncomfortable on the neck, and has dizziness, palpitation, irritability and irritability. Color ultrasonic display: thyroid right lobe multiple nodules, wherein the larger nodules are 1.2 x 1.5cm, the boundaries are clear, the shapes are regular, thyroid nodules are diagnosed, after taking the traditional Chinese medicine powder provided by the invention, the nodules are reduced after one treatment course, after taking two treatment courses, the nodules disappear, and the thyroid gland normality is checked. The disease does not relapse after two years of follow-up visit after the cure.
Case 2: certain old woman in 38 years old with one year of illness, feeling of oppression in chest, shortness of breath, dysphoria, irritability, dry throat with foreign body sensation, color Doppler ultrasound shows: thyroid double-leaf multiple nodules, wherein the larger one is 0.9 x 1.8cm and 1.0 x 1.5cm, thyroid nodules are diagnosed, after one treatment course, the nodules are reduced, foreign body sensation disappears, vexation and irritability happen occasionally, chest distress occurs, after two treatment courses, the nodules disappear, thyroid gland is checked to be normal, and after the treatment, the thyroid nodules do not relapse in 2 years.
Case 3: a certain Liu is a male, is 50 years old, suffers from five years of illness, often feels uncomfortable neck, feels foreign body, is vexed and irritative, shakes hands, is stuffy in chest and is dizziness. Color ultrasonic display: the size of the single nodule in the right thyroid lobe was 0.7 x 0.9cm and was diagnosed as: thyroid right lobe nodule. After taking the traditional Chinese medicine powder provided by the invention, nodules are reduced to some extent after one treatment course, foreign body sensation disappears, occasionally chest distress, dizziness and irritability disappear after two treatment courses, thyroid gland is checked to be normal, and no recurrence is caused after two follow-up visits after recovery.
The specific implementation mode is as follows:
the invention is further illustrated by the following examples:
example 1: a pure traditional Chinese medicine preparation for treating thyroid nodule comprises the following components in parts by weight: 15 parts of selfheal, 15 parts of dandelion, 10 parts of fructus forsythiae, 10 parts of rhizoma bolbostemmae, 30 parts of raw oyster, 10 parts of radix ranunculi ternati, 15 parts of spina gleditsiae, 10 parts of radix curcumae, 20 parts of raw turtle shell, 5 parts of edible tulip and 10 parts of semiaquilegia adoxoides. Cleaning, draining, oven drying at 55-70 deg.C for 2-4 hr, respectively processing the dried raw materials, pulverizing into powder, sieving with 80-100 mesh sieve, mixing with a stirrer, and making into pill or powder. The preparation is administered at a dose of 10g for 2 times a day 30 min after meals, and 2 months is a treatment course.
Example 2: a pure traditional Chinese medicine preparation for treating thyroid nodule comprises the following components in parts by weight: 25 parts of selfheal, 25 parts of dandelion, 12 parts of fructus forsythiae, 15 parts of rhizoma bolbostemmae, 45 parts of raw oyster, 15 parts of ternate buttercup root, 16 parts of spina gleditsiae, 12 parts of radix curcumae, 25 parts of raw turtle shell, 8 parts of edible tulip and 12 parts of semiaquilegia adoxoides by weight, cleaning and draining the raw materials according to the parts by weight, drying the raw materials for 2 to 4 hours at the temperature of between 55 and 70 ℃, respectively processing the dried raw materials, grinding the raw materials into powder, sieving the powder by a sieve of between 80 and 100 meshes, uniformly mixing the powder by a stirrer and preparing the pill or powder. The preparation is administered at a dose of 10g for 2 times a day 30 min after meals, and 2 months is a treatment course.
Example 3: a pure traditional Chinese medicine preparation for treating thyroid nodule comprises the following components in parts by weight: 30 parts of selfheal, 30 parts of dandelion, 20 parts of fructus forsythiae, 20 parts of rhizoma bolbostemmae, 60 parts of raw oyster, 20 parts of ternate buttercup root, 20 parts of spina gleditsiae, 20 parts of radix curcumae, 30 parts of raw turtle shell, 10 parts of edible tulip and 15 parts of semiaquilegia root, the raw materials are cleaned according to the parts by weight, drained and dried at the temperature of 55-70 ℃ for 2-4h, the dried raw materials are respectively processed, ground into powder, sieved by a sieve of 80-100 meshes, and uniformly mixed by a stirrer to prepare pills or powder. The preparation is administered at a dose of 10g for 2 times a day 30 min after meals, and 2 months is a treatment course.
Claims (4)
1. A pure traditional Chinese medicine preparation for treating thyroid nodule is prepared from the following raw materials in parts by weight: 15-30 parts of selfheal, 15-30 parts of dandelion, 10-20 parts of fructus forsythiae, 10-20 parts of rhizoma bolbostemmae, 30-60 parts of raw oyster, 10-20 parts of ternate buttercup root, 15-20 parts of spina gleditsiae, 10-20 parts of radix curcumae, 20-30 parts of raw turtle shell, 5-10 parts of edible tulip and 10-15 parts of semiaquilegia adoxoides.
2. The traditional Chinese medicine preparation for treating thyroid nodules according to claim 1, wherein: the feed is prepared from the following raw materials in parts by weight: 20-25 parts of selfheal, 20-25 parts of dandelion, 10-15 parts of fructus forsythiae, 12-18 parts of rhizoma bolbostemmae, 40-50 parts of raw oyster, 12-18 parts of ternate buttercup root, 15-18 parts of spina gleditsiae, 10-15 parts of radix curcumae, 25-28 parts of raw turtle shell, 5-8 parts of edible tulip and 10-12 parts of semiaquilegia adoxoides.
3. The traditional Chinese medicine preparation for treating thyroid nodules according to claim 1, wherein: the feed is prepared from the following raw materials in parts by weight: 25 parts of selfheal, 25 parts of dandelion, 12 parts of fructus forsythiae, 15 parts of rhizoma bolbostemmae, 45 parts of raw oyster, 15 parts of radix ranunculi ternati, 16 parts of spina gleditsiae, 12 parts of radix curcumae, 25 parts of raw turtle shell, 8 parts of edible tulip and 12 parts of semiaquilegia adoxoides.
4. A method for preparing a pure traditional Chinese medicine preparation for treating thyroid nodules, which is characterized in that the dosage form of the traditional Chinese medicine preparation in any one of claims 1 to 3 is pills or powder.
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| CN114042135B (en) * | 2021-11-11 | 2023-03-24 | 山东中医药大学 | Pharmaceutical composition for treating thyroid nodule and preparation method thereof |
| CN115040574B (en) * | 2022-06-10 | 2023-05-12 | 重庆市中药研究院 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating thyroid nodule and preparation method thereof |
| CN116098964B (en) * | 2023-01-31 | 2023-11-24 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | Traditional Chinese medicine composition for treating thyroid nodule and preparation and application thereof |
| CN117338893A (en) * | 2023-12-04 | 2024-01-05 | 云南中医药大学 | Pharmaceutical composition for resolving hard mass, preparation and application thereof |
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