CN114615984B - 作为klk5/7双重抑制剂的苯并噁嗪酮化合物 - Google Patents

作为klk5/7双重抑制剂的苯并噁嗪酮化合物 Download PDF

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Publication number
CN114615984B
CN114615984B CN202080069819.7A CN202080069819A CN114615984B CN 114615984 B CN114615984 B CN 114615984B CN 202080069819 A CN202080069819 A CN 202080069819A CN 114615984 B CN114615984 B CN 114615984B
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compound
formula
pharmaceutically acceptable
skin
subject
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Chinese (zh)
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CN114615984A (zh
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A·贝茨
R·赞博尼
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Molecular Skin Therapy
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Molecular Skin Therapy
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN202080069819.7A 2019-10-01 2020-09-30 作为klk5/7双重抑制剂的苯并噁嗪酮化合物 Active CN114615984B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962909006P 2019-10-01 2019-10-01
US62/909,006 2019-10-01
PCT/US2020/053369 WO2021067335A1 (en) 2019-10-01 2020-09-30 Benzoxazinone compounds as klk5/7 dual inhibitors

Publications (2)

Publication Number Publication Date
CN114615984A CN114615984A (zh) 2022-06-10
CN114615984B true CN114615984B (zh) 2025-02-07

Family

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CN202080069819.7A Active CN114615984B (zh) 2019-10-01 2020-09-30 作为klk5/7双重抑制剂的苯并噁嗪酮化合物

Country Status (13)

Country Link
US (2) US11643420B2 (enExample)
EP (1) EP4037687B1 (enExample)
JP (1) JP7854389B2 (enExample)
KR (1) KR102994600B1 (enExample)
CN (1) CN114615984B (enExample)
AU (1) AU2020359526B2 (enExample)
BR (1) BR112022005881A2 (enExample)
CA (1) CA3151626A1 (enExample)
ES (1) ES3053975T3 (enExample)
IL (1) IL291398B2 (enExample)
MX (1) MX2022003929A (enExample)
TW (1) TWI918610B (enExample)
WO (1) WO2021067335A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
AU2020349509A1 (en) 2019-09-18 2022-03-31 Genentech, Inc. Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use
MX2022003929A (es) 2019-10-01 2022-06-14 Molecular Skin Therapeutics Inc Compuestos de benzoxazinona como inhibidores dobles de klk5/7.
TW202304890A (zh) * 2021-04-14 2023-02-01 美商百歐克斯製藥公司 Klk5雙環雜芳香族抑制劑

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN106132941A (zh) * 2014-01-23 2016-11-16 西可斯拉制药公司 用于治疗皮肤病的苯并恶嗪酮衍生物

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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106132941A (zh) * 2014-01-23 2016-11-16 西可斯拉制药公司 用于治疗皮肤病的苯并恶嗪酮衍生物

Also Published As

Publication number Publication date
TWI918610B (zh) 2026-03-21
MX2022003929A (es) 2022-06-14
TW202126631A (zh) 2021-07-16
AU2020359526B2 (en) 2026-07-16
IL291398B1 (en) 2025-01-01
US12281123B2 (en) 2025-04-22
IL291398A (en) 2022-05-01
ES3053975T3 (en) 2026-01-28
US20210101911A1 (en) 2021-04-08
KR102994600B1 (ko) 2026-07-22
US11643420B2 (en) 2023-05-09
US20240067658A1 (en) 2024-02-29
CN114615984A (zh) 2022-06-10
CA3151626A1 (en) 2021-04-08
EP4037687A4 (en) 2023-09-27
JP7854389B2 (ja) 2026-05-01
EP4037687A1 (en) 2022-08-10
AU2020359526A1 (en) 2022-04-21
KR20220091488A (ko) 2022-06-30
BR112022005881A2 (pt) 2022-06-21
WO2021067335A1 (en) 2021-04-08
JP2022551583A (ja) 2022-12-12
EP4037687B1 (en) 2025-10-29
IL291398B2 (en) 2025-05-01

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