CN114615897A - 牛乳分离的粉末状外泌体、营养组合物和方法 - Google Patents

牛乳分离的粉末状外泌体、营养组合物和方法 Download PDF

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Publication number
CN114615897A
CN114615897A CN202080076490.7A CN202080076490A CN114615897A CN 114615897 A CN114615897 A CN 114615897A CN 202080076490 A CN202080076490 A CN 202080076490A CN 114615897 A CN114615897 A CN 114615897A
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Prior art keywords
exosomes
milk
powdered
nutritional composition
isolated
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Pending
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CN202080076490.7A
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English (en)
Chinese (zh)
Inventor
J·M·洛佩兹佩德罗萨
J·加西亚马丁内斯
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Abbott Laboratories
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Abbott Laboratories
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1276—Globules of milk; Constituents thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN202080076490.7A 2019-11-08 2020-11-05 牛乳分离的粉末状外泌体、营养组合物和方法 Pending CN114615897A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382978 2019-11-08
EP19382978 2019-11-08
PCT/US2020/059155 WO2021092209A1 (en) 2019-11-08 2020-11-05 Bovine milk-isolated powdered exosomes, nutritional compositions and methods

Publications (1)

Publication Number Publication Date
CN114615897A true CN114615897A (zh) 2022-06-10

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CN202080076490.7A Pending CN114615897A (zh) 2019-11-08 2020-11-05 牛乳分离的粉末状外泌体、营养组合物和方法

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Country Link
US (1) US20220395535A1 (enExample)
EP (2) EP4054604B1 (enExample)
JP (1) JP7769607B2 (enExample)
CN (1) CN114615897A (enExample)
CA (1) CA3156527A1 (enExample)
DK (1) DK4054604T3 (enExample)
ES (1) ES3069472T3 (enExample)
IL (1) IL292703A (enExample)
MX (2) MX2022005462A (enExample)
PH (1) PH12022551086A1 (enExample)
WO (1) WO2021092209A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115038454A (zh) * 2020-08-31 2022-09-09 庆熙大学校产学协力团 包含牛乳外泌体的用于诱导棕色脂肪化的组合物
CN115873786A (zh) * 2022-12-29 2023-03-31 陕西慧康生物科技有限责任公司 一种鲜乳中外泌体规模化提取方法
CN116036298A (zh) * 2021-10-28 2023-05-02 谛邈生物科技(北京)有限公司 牛奶外泌体在制备药物载体中的应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115361879A (zh) * 2020-04-03 2022-11-18 雅培制药有限公司 牛奶外泌体产品和方法、营养组合物和治疗方法
WO2023076144A1 (en) * 2021-10-29 2023-05-04 Abbott Laboratories Methods and compositions for improving insulin production and secretion
JP2025514761A (ja) * 2022-04-21 2025-05-09 アボット・ラボラトリーズ 糖尿病の発症を遅らせる又は糖尿病のリスクを軽減するための方法及び組成物
CN117618575A (zh) * 2022-08-25 2024-03-01 逸惟生物科技(北京)有限公司 一种牛奶外泌体制剂及其应用
ES2977833A1 (es) 2023-01-17 2024-08-30 Univ Madrid Autonoma Procedimiento para la obtención de exosomas a partir de mazada, exosomas obtenidos y aplicaciones de los mismos
WO2024249615A1 (en) * 2023-05-31 2024-12-05 Abbott Laboratories Bovine milk exosomes for delivering vitamin d

Citations (6)

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CN103596440A (zh) * 2011-06-08 2014-02-19 雀巢产品技术援助有限公司 含有外源性乳脂肪球膜组分的营养组合物
CN103906440A (zh) * 2011-10-21 2014-07-02 雀巢产品技术援助有限公司 乳清蛋白胶束用于处于肥胖症或糖尿病风险中的婴儿的用途
WO2014134132A1 (en) * 2013-02-26 2014-09-04 University Of Louisville Research Foundation, Inc. Milk-derived microvesicle compositions and related methods
CN106455662A (zh) * 2014-06-03 2017-02-22 雅培制药有限公司 包含亲脂性活性成分的营养组合物
WO2017090049A1 (en) * 2015-11-29 2017-06-01 Hadasit Medical Research Services And Development Ltd. Supplementation of milk formulas with microvesicles isolated from milk
US20170296627A1 (en) * 2014-09-05 2017-10-19 Exerkine Corporation Exersomes, methods of producing and method of using

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JP2639726B2 (ja) * 1989-02-27 1997-08-13 森永乳業株式会社 水溶性食物繊維およびその製造法
US6596302B2 (en) * 2000-04-13 2003-07-22 Abbott Laboratories Infant formulas containing long-chain polyunsaturated fatty acids and uses thereof
EP1656839A1 (en) * 2004-11-11 2006-05-17 N.V. Nutricia Nutrition containing lipid blend
IT201600109148A1 (it) * 2016-10-28 2018-04-28 Pharmaexceed Srl Processo per isolare e liofilizzare vescicole extracellulari
CN109468265B (zh) * 2018-11-06 2021-06-22 广州市创唯曦旺生物科技有限公司 一种提取乳外泌体的方法

Patent Citations (6)

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CN103596440A (zh) * 2011-06-08 2014-02-19 雀巢产品技术援助有限公司 含有外源性乳脂肪球膜组分的营养组合物
CN103906440A (zh) * 2011-10-21 2014-07-02 雀巢产品技术援助有限公司 乳清蛋白胶束用于处于肥胖症或糖尿病风险中的婴儿的用途
WO2014134132A1 (en) * 2013-02-26 2014-09-04 University Of Louisville Research Foundation, Inc. Milk-derived microvesicle compositions and related methods
CN106455662A (zh) * 2014-06-03 2017-02-22 雅培制药有限公司 包含亲脂性活性成分的营养组合物
US20170296627A1 (en) * 2014-09-05 2017-10-19 Exerkine Corporation Exersomes, methods of producing and method of using
WO2017090049A1 (en) * 2015-11-29 2017-06-01 Hadasit Medical Research Services And Development Ltd. Supplementation of milk formulas with microvesicles isolated from milk

Non-Patent Citations (2)

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BODO C.MELNIK: "The Pathogenic Role of Persistent Milk Signaling in mTORCl-and Milk-MicroRNA-Driven Type 2 Diabetes Mellitus", CURRENT DIABETES REVIEWS, vol. 11, pages 46 - 62, XP055773005 *
MELNIK BODO C. ET AL: "Exosomes of pasteurized milk: potential pathogens of Western diseases", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 17, no. 1, pages 1 - 33, XP055773012, DOI: 10.1186/s12967-018-1760-8 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115038454A (zh) * 2020-08-31 2022-09-09 庆熙大学校产学协力团 包含牛乳外泌体的用于诱导棕色脂肪化的组合物
CN116036298A (zh) * 2021-10-28 2023-05-02 谛邈生物科技(北京)有限公司 牛奶外泌体在制备药物载体中的应用
CN115873786A (zh) * 2022-12-29 2023-03-31 陕西慧康生物科技有限责任公司 一种鲜乳中外泌体规模化提取方法

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CA3156527A1 (en) 2021-05-14
MX2022005462A (es) 2022-05-26
WO2021092209A1 (en) 2021-05-14
PH12022551086A1 (en) 2024-06-24
EP4054604A1 (en) 2022-09-14
EP4736670A1 (en) 2026-05-06
JP2023500674A (ja) 2023-01-10
EP4054604B1 (en) 2026-03-04
MX2026004694A (es) 2026-06-01
JP7769607B2 (ja) 2025-11-13
US20220395535A1 (en) 2022-12-15
IL292703A (en) 2022-07-01
ES3069472T3 (en) 2026-06-08
DK4054604T3 (da) 2026-05-26

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Application publication date: 20220610