MX2022005462A - Exosomas en polvo aislados de la leche bovina, composiciones alimenticias y metodos. - Google Patents

Exosomas en polvo aislados de la leche bovina, composiciones alimenticias y metodos.

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Publication number
MX2022005462A
MX2022005462A MX2022005462A MX2022005462A MX2022005462A MX 2022005462 A MX2022005462 A MX 2022005462A MX 2022005462 A MX2022005462 A MX 2022005462A MX 2022005462 A MX2022005462 A MX 2022005462A MX 2022005462 A MX2022005462 A MX 2022005462A
Authority
MX
Mexico
Prior art keywords
exosomes
bovine milk
whey fraction
pellet
powdered
Prior art date
Application number
MX2022005462A
Other languages
English (en)
Inventor
Pedrosa José María López
Martínez Jorge García
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2022005462A publication Critical patent/MX2022005462A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1276—Globules of milk or constituents thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Los exosomas en polvo aislados de la leche bovina comprenden exosomas intactos. Las composiciones alimenticias comprenden proteínas, carbohidratos y/o grasas y exosomas aislados de la leche bovina. Un método para preparar exosomas en polvo comprende centrifugar la leche bovina para formar una capa superior de fracción lipídica, una capa intermedia de fracción de suero lácteo y un primer sedimento de células y restos, separar la fracción de suero lácteo y centrifugar la fracción de suero lácteo separada para eliminar la grasa adicional, los agregados de caseína y los restos y formar una fracción de suero lácteo sustancialmente transparente, microfiltrar la fracción de suero lácteo sustancialmente transparente para eliminar los restos residuales, centrifugar la fracción de suero lácteo microfiltrada para obtener un sedimento que contiene exosomas, incubar el sedimento que contiene exosomas en un medio acuoso para disolver el sedimento sin romper las membranas exosómicas para proporcionar una suspensión de exosomas y secar la suspensión para obtener los exosomas en polvo. Los métodos para reducir el riesgo de desarrollar o tratar la resistencia a la insulina, la prediabetes o la diabetes en un sujeto emplean exosomas aislados de la leche bovina.
MX2022005462A 2019-11-08 2020-11-05 Exosomas en polvo aislados de la leche bovina, composiciones alimenticias y metodos. MX2022005462A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19382978 2019-11-08
PCT/US2020/059155 WO2021092209A1 (en) 2019-11-08 2020-11-05 Bovine milk-isolated powdered exosomes, nutritional compositions and methods

Publications (1)

Publication Number Publication Date
MX2022005462A true MX2022005462A (es) 2022-05-26

Family

ID=68610122

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022005462A MX2022005462A (es) 2019-11-08 2020-11-05 Exosomas en polvo aislados de la leche bovina, composiciones alimenticias y metodos.

Country Status (8)

Country Link
US (1) US20220395535A1 (es)
EP (1) EP4054604A1 (es)
JP (1) JP2023500674A (es)
CN (1) CN114615897A (es)
CA (1) CA3156527A1 (es)
IL (1) IL292703A (es)
MX (1) MX2022005462A (es)
WO (1) WO2021092209A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230263178A1 (en) * 2020-04-03 2023-08-24 Abbott Laboratories Bovine milk exosome products and methods, nutritional compositions, and therapeutic methods
KR102559516B1 (ko) * 2020-08-31 2023-07-26 경희대학교 산학협력단 우유 엑소좀을 포함하는 갈색지방화 유도용 조성물
CN116036298A (zh) * 2021-10-28 2023-05-02 谛邈生物科技(北京)有限公司 牛奶外泌体在制备药物载体中的应用
WO2023076144A1 (en) * 2021-10-29 2023-05-04 Abbott Laboratories Methods and compositions for improving insulin production and secretion
WO2023205762A1 (en) * 2022-04-21 2023-10-26 Abbott Laboratories Methods and compositions for slowing diabetes development or reducing a risk of diabetes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014516565A (ja) * 2011-06-08 2014-07-17 ネステク ソシエテ アノニム 外因性乳脂肪球膜成分を有する栄養組成物
EP2583562A1 (en) * 2011-10-21 2013-04-24 Nestec S.A. Use of whey protein micelles for infants at risk of obesity or diabetes
US9943482B2 (en) * 2013-02-26 2018-04-17 University Of Louisville Research Foundation, Inc. Milk-derived microvesicle compositions and related methods
CN106455662A (zh) * 2014-06-03 2017-02-22 雅培制药有限公司 包含亲脂性活性成分的营养组合物
CA2960161A1 (en) * 2014-09-05 2016-03-10 Exerkine Corporation Exosome isolation
US10874114B2 (en) * 2015-11-29 2020-12-29 Hadasit Medical Research Services And Development Ltd. Supplementation of milk formulas with microvesicles isolated from milk

Also Published As

Publication number Publication date
CA3156527A1 (en) 2021-05-14
JP2023500674A (ja) 2023-01-10
US20220395535A1 (en) 2022-12-15
EP4054604A1 (en) 2022-09-14
IL292703A (en) 2022-07-01
CN114615897A (zh) 2022-06-10
WO2021092209A1 (en) 2021-05-14

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