CN114599779B - 用于单细胞蛋白质或生物质生产的菌株和方法 - Google Patents
用于单细胞蛋白质或生物质生产的菌株和方法 Download PDFInfo
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- CN114599779B CN114599779B CN202080069118.3A CN202080069118A CN114599779B CN 114599779 B CN114599779 B CN 114599779B CN 202080069118 A CN202080069118 A CN 202080069118A CN 114599779 B CN114599779 B CN 114599779B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
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Abstract
本发明涉及黄色杆菌属的细菌菌株,以及使用黄色杆菌属的细菌用于生产蛋白质或生物质的连续培养方法,所述方法包括向细胞供应气体和矿物质。本发明还涉及这些方法的产物以及这些产物在例如食物或饲料中的用途。
Description
技术领域
本发明涉及利用微生物生产蛋白质和/或其它大分子。特别地,本发明涉及新型细菌菌株和利用细菌用于生产蛋白质或生物质的连续培养方法,在该连续培养方法中,将气体和矿物质供应给细胞。本发明还涉及这些方法的产物以及这些产物在例如食物或饲料中的用途。
背景技术
不断增长的世界人口、气候变化和水资源的短缺日益对传统农业造成威胁,并且因此对食物和饲料的充足供应造成威胁。因此,正在调查有机分子如蛋白质的替代来源。潜在的替代品是单细胞生产,即使用微生物生产蛋白质和/或其它大分子。
化能自养微生物已得到描述,其能够在具有氢气作为能源和二氧化碳作为唯一碳源的基本矿物质培养基上生长。关于这些微生物的综述,参见例如,Shively等人(1998)Annu Rev Microbiol 52:191。专利申请WO2018144965描述了用于将气态底物转换成高蛋白生物质的各种微生物和生物过程。Andersen等人(1979)Biochim Biophys Acta 585:1-11描述了真氧产碱菌(Alcaligenes eutrophus)的突变株,所述真氧产碱菌是在异养和自养条件下很容易生长的氢细菌。具有改变的核酮糖-1,5-二磷酸羧化酶/加氧酶(rubisco)活性的突变体得到表征。Ohmiya等人(2003)J.Biosci.Bioeng.95:549-561综述了微生物基因对难分解生物质(recalcitrant biomass)利用的应用。Yu Jian等人(2013)Int JHydrogen Ener 38:8683-8690描述了通过氢氧化细菌分离株的二氧化碳固定。在适度的氧浓度(10摩尔%)下,测量到50%的高能效。
然而,各种化能自养微生物在生长速率、产率、生物质组成以及与用作食物成分有关的性质(例如在人消费中的安全性、味道、气味、口感、在烹饪中的技术和功能性质等)方面具有不同的性质。并非每一种化能自养微生物都具有足够的生长速率且提供足够的产率,也不是每一种方法都可以现实地升级为经济上可行的大规模方法。为了具有功能性蛋白质的足够输出,例如用于食物或饲料应用,重要的是找到合适的生产生物和可以以大规模执行的合适方法。本发明解决了这一需求。
发明内容
在第一个主要方面,本发明涉及分离的细菌菌株VTT-E-193585或其衍生物。
在进一步的方面,本发明涉及包含本发明的细菌菌株或其衍生物的培养物。此外,本发明涉及用于生产生物质(biomass)和/或蛋白质的方法,所述方法包括培养本发明的细菌菌株或其衍生物。
在一个进一步方面,本发明涉及用于生产生物质和/或蛋白质的方法,所述方法包括在使用无机碳源和作为能源的氢的连续培养中培养黄色杆菌属(Xanthobacter)的细菌菌株,其中所述无机碳源包括二氧化碳。
在进一步的主要方面,本发明涉及通过本发明的方法获得或可获得的大量蛋白质、生物质或者非蛋白质细胞或化学组分,以及通过本发明的方法获得或可获得(obtainable)的食物或饲料产物。
附图说明
图1.在以VTT-E-193585保藏的分离的细菌菌株的化能自养200-L培养期间,在600nm处测量的光密度(黑色圆圈)和光密度探头读数。
图2.在以VTT-E-193585保藏的分离的细菌菌株在不同的氮源上的平行化能自养200-mL培养期间,在600nm处测量的光密度。
具体实施方式
当在本文中使用时,例如在菌株的背景下的术语“分离的”意指从其天然环境中分离。优选地,分离的菌株是纯的,即不含其它菌株。
当在本文中在菌株的背景下使用时,术语“衍生物”指衍生自参考菌株,即使用参考菌株作为起点生成的菌株。例如,遗传改造或以其它方式突变或遗传修饰的菌株是此类衍生物的一个实施方式。遗传修饰包括点突变,以及插入或缺失,包括整个基因座或其片段的插入或缺失。衍生物优选具有与参考菌株相比的少于10个遗传修饰,例如少于5个,例如4、3、2或1个遗传修饰。
当在本文中使用时,名词“培养物”指在液体培养基中的活细胞的悬浮液。
术语“生物质”具有其在细菌发酵领域的通常含义,并且指细胞材料。
当在本文中使用时,术语“连续培养”指这样的培养方法,其中将新鲜培养基连续加入培养物中,并且将具有细菌培养物的培养基以基本上相同的速率连续取出。
本发明的方面和实施方式
在第一个主要方面,本发明涉及分离的细菌菌株VTT-E-193585或其衍生物。
菌株VTT-E-193585已从芬兰Naantali的波罗的海海岸分离。该生物体能够在限制氧的条件下,用氢作为能源和二氧化碳作为碳源的基本矿物质培养基,在合适的生物反应器条件下生长。16S测序和Illumina宏基因组学测序已显示了,该菌株极有可能是黄色杆菌属的成员,但不是已知的种。该细菌菌株高度适合于食物和饲料应用,因为干燥细胞粉末具有高蛋白质含量,并且含有所有必需氨基酸。它还含有比饱和脂肪酸更多的不饱和脂肪酸和高水平的B族维生素。可能引起过敏或毒性的肽聚糖和脂多糖的水平很低。执行了毒性分析,并且对于该菌株没有观察到遗传毒性或细胞毒性。另外,该菌株对抗生素普遍敏感。
菌株VTT-E-193585(SoF1)已于2019年6月11日保藏于芬兰P.O.Box 1000,FI-02044VTT的芬兰VTT技术研究中心(Technical Research Centre)的VTT培养物保藏中心(Culture Collection)中,该中心是根据布达佩斯条约的国际保藏机构。关于该菌株的特性和用于培养该菌株的方法的进一步信息在本文的实施例中提供。
在一个优选的实施方式中,如果该菌株是菌株VTT-E-193585的衍生物,则该衍生物已保留使用氢气作为能源和二氧化碳作为唯一碳源生长的能力。
在一个实施方式中,如果该菌株是菌株VTT-E-193585的衍生物,则该衍生物包含SEQ ID NO:1中所示的16S核糖体RNA,或者与SEQ ID NO:1具有至多20个核苷酸差异,例如与SEQ ID NO:1有1至10,例如1至5,例如一个、两个或三个核苷酸差异的16S核糖体RNA。
SEQ ID NO:1.菌株VTT-E-193585的16S核糖体RNA序列:
CTTGAGAGTTTGATCCTGGCTCAGAGCGAACGCTGGCGGCAGGCCTAACACATGCAAGTCGAGCGCCCAGCAATGGGAGCGGCAGACGGGTGAGTAACGCGTGGGGATGTGCCCAATGGTACGGAATAACCCAGGGAAACTTGGACTAATACCGTATGAGCCCTTCGGGGGAAAGATTTATCGCCATTGGATCAACCCGCGTCTGATTAGCTAGTTGGTGGGGTAACGGCCCACCAAGGCGACGATCAGTAGCTGGTCTGAGAGGATGATCAGCCACACTGGGACTGAGACACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGGACAATGGGCGCAAGCCTGATCCAGCCATGCCGCGTGTGTGATGAAGGCCTTAGGGTTGTAAAGCACTTTCGCCGGTGAAGATAATGACGGTAACCGGAGAAGAAGCCCCGGCTAACTTCGTGCCAGCAGCCGCGGTAATACGAAGGGGGCTAGCGTTGCTCGGAATCACTGGGCGTAAAGCGCACGTAGGCGGATCGTTAAGTCAGGGGTGAAATCCTGGAGCTCAACTCCAGAACTGCCCTTGATACTGGCGACCTTGAGTTCGAGAGAGGTTGGTGGAACTGCGAGTGTAGAGGTGAAATTCGTAGATATTCGCAAGAACACCAGTGGCGAAGGCGGCCAACTGGCTCGATACTGACGCTGAGGTGCGAAAGCGTGGGGAGCAAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGATGGATGCTAGCCGTTGGGCAGCTTGCTGTTCAGTGGCGCAGCTAACGCATTAAGCATCCCGCCTGGGGAGTACGGTCGCAAGATTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGTGGAGCATGTGGTTTAATTCGAAGCAACGCGCAGAACCTTACCAGCCTTTGACATGGCAGGACGATTTCCAGAGATGGATCTCTTCCAGCAATGGACCTGCACACAGGTGCTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTCGCCTCTAGTTGCCAGCATTCAGTTGGGCACTCTAGAGGGACTGCCGGTGATAAGCCGAGAGGAAGGTGGGGATGACGTCAAGTCCTCATGGCCCTTACGGGCTGGGCTACACACGTGCTACAATGGTGGTGACAGTGGGATGCGAAAGGGCGACCTCTAGCAAATCTCCAAAAGCCATCTCAGTTCGGATTGTACTCTGCAACTCGAGTGCATGAAGTTGGAATCGCTAGTAATCGTGGATCAGCATGCCACGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACACCATGGGAGTTGGCTTTACCCGAAGGCGCTGCGCTAACCCGCAAGGGAGGCAGGCGACCACGGTAGGGTCAGCGACTGGGGTGAAGTCGTAACAAGGTAGCCGTAGGGGAACCTGCGGCTGGATCACCTCCTTT
在一个进一步方面,本发明涉及包含本发明的细菌菌株或其衍生物的培养物。在一个优选的实施方式中,培养物的体积为100mL或更多,例如1L或更多,例如10L或更多,例如1000L或更多,例如10000L或更多,例如50000L或更多,例如100000L或更多,例如200000L或更多。
在一个进一步方面,本发明涉及用于生产生物质和/或蛋白质的方法,所述方法包括培养本发明的细菌菌株或其衍生物。在一个实施方式中,该方法用于生产生物质。在另一个实施方式中,该方法用于生产蛋白质。在一个实施方式中,该方法包括在使用无机碳源和作为能源的氢的连续培养中培养菌株,其中所述无机碳源包括二氧化碳。在一个进一步实施方式中,该方法用于生产生物质,并且包括在使用无机碳源和作为能源的氢的连续培养中培养菌株,其中所述无机碳源包括二氧化碳。该方法的各个进一步的实施方式在下文进行描述。
在一个进一步的主要方面,本发明涉及用于生产生物质和/或蛋白质的方法,所述方法包括在使用无机碳源和作为能源的氢的连续培养中培养黄色杆菌属的细菌菌株,其中所述无机碳源包括二氧化碳。在一个实施方式中,该方法用于生产生物质。在另一个实施方式中,该方法用于生产蛋白质。该方法的各个进一步的实施方式在下文进行描述。
根据基因组序列,以编号VTT-E-193585下保藏的菌株极有可能使用卡尔文-本森-巴瑟姆循环(Calvin-Benson-Bassham cycle)用于碳固定,其中二氧化碳分子与核酮糖1,5-二磷酸(ribulose 1,5-bisphosphate)的5碳链相连,形成两个甘油酸-3-磷酸(glycerate 3-phosphate)分子。这致使菌株能够合成其生长所需的所有其它有机分子。来自氢的能量极有可能通过NAD+还原氢化酶和/或NiFe氢化酶进入细胞内。实质上,这是其中氢(H2)氧化为H+,且NAD+还原为NADH的氧化还原反应。除ATP之外,NADH是活生物内部的主要能量载体之一。可替代地,一些其它的能当量通过使用H2的另一种氢化酶还原。卡尔文-本森-巴瑟姆循环需要以ATP和NADH/NADPH形式的能量,以便固定CO2。该菌株极有可能通过氧化磷酸化生成ATP,其由四个蛋白质复合物组成,生成跨越膜的质子梯度。质子梯度主要使用来自NADH的能量生成。质子梯度驱动ATP合酶复合物生成ATP。根据基因组序列,该菌株具有细菌F型ATP合酶。
当指定该方法包括用无机碳源培养菌株时,应理解无机碳源是培养物中的主要碳源。因此,在培养物中可能存在的次要有机碳源,但培养物的主要代谢和生长基于利用无机碳源优选二氧化碳作为碳源。优选地,供应给培养物的其为有机的碳的比例是在该方法期间供应给培养物的所有碳中的小于5%,例如小于1%,例如小于0.1%。优选地,不将有机碳源供应给该方法。
类似地,当指定该方法包括用氢(H2)作为能源培养菌株时,应理解氢是培养物中的主要能源。因此,在培养物中可能存在其它的次要能源,例如可能作为氮源供应的氨,或少量的有机化合物,但培养物的主要代谢和生长基于利用氢作为能源。在整个过程中,氢优选通过水电解产生;即通过用电将水分解成氢气和氧气。因此,氢气和氧气由附近的电解器提供给生物反应器。可替代地,电极可以放置在生物反应器内部,以在生物反应器而不是分开的电解器中产生氢和氧。
包含二氧化碳的无机碳源可以包含其它无机碳源,例如一氧化碳。在一个实施方式中,只向培养物提供以气态形式的碳源。在一个优选的实施方式中,二氧化碳是向培养物提供的唯一的无机碳源,并且实际上也是唯一的碳源。在一个实施方式中,只向培养物提供气体和矿物质,并且所提供的气体中的二氧化碳水平在10%和50%之间,例如在15%和45%之间,例如在20%和40%之间,例如在25%和35%之间,例如在26%和30%之间。
在另一个实施方式中,向培养物提供气体和矿物质,并且所提供的气体中的氢(H2)水平在30%和80%之间,例如在35%和75%之间,例如在40%和70%之间,例如在45%和65%之间,例如在50%和60%之间。
在另一个实施方式中,向培养物提供气体和矿物质,并且所提供的气体中的氧(O2)水平在10%和25%之间,例如在15%和20%之间,例如在16%和18%之间。在另一个实施方式中,所提供的氧水平使得培养物中的溶解氧水平维持在5%和10%之间。
在一个优选的实施方式中,只向培养物提供气体和矿物质,并且所提供的气体包含H2、CO2和O2,其中H2的百分比在40%和70%之间,CO2的百分比在18%和28%之间,且O2的百分比在12%和22%之间。
通常,本发明的方法包括氮源的添加。氮源可以例如以氢氧化铵、铵盐如硫酸铵或氯化铵、氨、尿素或硝酸盐如硝酸钾的形式提供。在其它实施方式中,提供氮气(N2)作为氮源。在一个优选的实施方式中,氮源是氢氧化铵或铵盐如硫酸铵。
在一个实施方式中,所提供的氮源是氢氧化铵,其浓度在100mg/L和10g/L之间,例如在250mg/L和4g/L之间,例如在0.5g/L和2g/L之间,例如在0.75g/L和1.5g/L之间。
通常,本发明的方法包括矿物质的添加,所述矿物质例如含有铵、磷酸盐、钾、钠、钒、铁、硫酸盐、镁、钙、钼、锰、硼、锌、钴、硒、碘、铜和/或镍的矿物质。合适的矿物质培养基是本领域众所周知的,并且已例如在Thermophilic Bacteria,CRC Press,Boca Raton,FL,Jacob K.Kristjansson,编辑,1992中,例如在第87页,表4上进行描述。
在一个实施方式中,所添加的矿物质包括下述中的一种或多种:氨、铵(例如,氯化铵(NH4Cl)、硫酸铵((NH4)2SO4))、硝酸盐(例如,硝酸钾(KNO3))、尿素或有机氮源;磷酸盐(例如,磷酸氢二钠(Na2HPO4)、磷酸钾(KH2PO4)、磷酸(H3PO4)、二硫代磷酸钾(K3PS2O2)、正磷酸钾(K3PO4)、磷酸氢二钠(Na2HPO4·2H2O)、磷酸氢二钾(K2HPO4)或磷酸二氢钾(KH2PO4);硫酸盐;酵母提取物;螯合铁(例如由EDTA或柠檬酸螯合的);钾(例如,磷酸钾(KH2PO4)、硝酸钾(KNO3)、碘化钾(KI)、溴化钾(KBr));以及其它无机盐、矿物质和微量营养素(例如,氯化钠(NaCl)、硫酸镁(MgSO4·7H2O)或氯化镁(MgCl2)、氯化钙(CaCl2)、硫酸钙(CaSO4)或碳酸钙(CaCO3)、硫酸锰(MnSO4·7H2O)或氯化锰(MnCl2)、氯化铁(FeCl2)、硫酸亚铁(FeSO4 7H2O)或氯化亚铁(FeCl2 4H2O)、碳酸氢钠(NaHCO3)或碳酸钠(Na2CO3)、硫酸锌(ZnSO4)或氯化锌(ZnCl2)、钼酸铵(NH4MoO4)或钼酸钠(Na2MoO4·2H2O)、硫酸亚铜(CuSO4)或氯化铜(CuCl2·2H2O)、氯化钴(CoCl2·6H2O)或硫酸钴(CoSO4)、氯化铝(AlCl3·6H2O)、氯化锂(LiCl)、硼酸(H3BO3)、氯化镍(NiCl2·6H2O)或硫酸镍(NiSO4)、氯化锡(SnCl2·H2O)、氯化钡(BaCl2·2H2O)、硒酸铜(CuSeO4 5H2O)、硒酸钠(Na2SeO4)或亚硒酸钠(Na2SeO3)、偏钒酸钠(NaVO3)、铬盐)。
在一个优选的实施方式中,本发明的方法包括以下中的一项或更多项或全部的添加:NH4OH、KH2PO4、Na2HPO4·2H2O、NaVO3·H2O、FeSO4x7H2O、MgSO4·7H2O、CaSO4、Na2MoO4·2H2O、MnSO4·7H2O、ZnSO4·7H2O、H3BO3、CoSO4、CuSO4、NiSO4。
在一个实施方式中,向细胞提供的培养基包含小于1g/L的氯盐,例如小于0.25g/L的氯盐,例如小于0.1g/L的氯盐,例如小于0.025g/L的氯盐,例如小于0.01g/L的氯盐。在一个实施方式中,不向培养物供应氯盐。
在另一个实施方式中,在该方法期间不供应维生素,即向培养物提供的培养基不含维生素。
在另一个实施方式中,在该方法期间不供应氨基酸,即向培养物提供的培养基不含氨基酸。
在另一个实施方式中,在该方法期间不供应有机化合物,即向培养物提供的培养基不含任何有机化合物。
在某些实施方式中,细菌培养物的pH控制在一定水平下。在某些实施方式中,pH控制在对于细菌维持和/或生长和/或有机化合物生产的最佳范围内。在一个实施方式中,培养物中的pH维持5.5和8.0之间,例如在6.5和7.0之间,例如在6.8下。
在某些实施方式中,控制细菌培养物的温度。在某些实施方式中,温度控制在对于细菌维持和/或生长和/或有机化合物生产的最佳范围内。在一个实施方式中,培养物在25℃和40℃之间,例如在28℃和32℃之间,例如在30℃的温度下生长。
通常,本发明的方法在生物反应器中进行。生物反应器用于细胞的培养,所述细胞可以维持在其生长曲线的特定阶段下。生物反应器的使用在许多方面对于培养化能自养生长是有利的。一般地,生长条件的控制,包括溶解的二氧化碳、氧和其它气体如氢,以及其它溶解的营养素、微量元素、温度和pH的控制在生物反应器中得到促进。营养培养基以及气体可以作为分批添加、或定期地或响应检测到的消耗或编程的设定点、或在培养物生长和/或维持期间连续地加入生物反应器中。在连续培养方法中,将营养培养基以及气体连续加入生物反应器中。此外,含细菌的培养基也连续地从生物反应器中取出。
在一个优选的实施方式中,细菌培养物的体积为100mL或更多,例如1L或更多,例如10L或更多,例如100L或更多,例如1000L或更多,例如10000L或更多,例如50000L或更多,例如100000L或更多,例如200000L或更多。
在一个实施方式中,培养物的生产率为多于0.1g细胞干重/升/小时,例如多于0.2,例如多于0.3,例如多于0.4,例如多于0.5,例如多于0.6,例如多于0.7,例如多于0.8,例如多于0.9,例如多于1g/升/小时。
细菌可以直接从细胞库接种,或经由种子培养物在较小规模下接种。优选地,新鲜培养基向培养物的供应和具有细菌的用过培养基的取出以相同的速率发生,使得生物反应器中的体积保持相同。
在一个实施方式中,在达到合适的细胞密度的初始阶段后,细菌以稳态或假稳态生长,连续保持在其对数阶段,其OD600高于5,例如高于10,例如高于20,例如在50和200之间,例如在50和100之间。
在本发明的方法的一个实施方式中,细菌菌株具有0.04–0.12h-1的生长速率。
在本发明的方法的另一个实施方式中,连续阶段中的液体进料速率为生长速率的50-80%。
黄色杆菌属是来自黄色杆菌科(Xanthobacteraceae)的革兰氏阴性菌的属。
在一个实施方式中,在本发明的方法中使用的黄色杆菌属菌株是使用卡尔文本森巴瑟姆途径将二氧化碳转换成活生物必需的有机化合物,例如葡萄糖的菌株。
在一个实施方式中,在本发明的方法中使用的黄色杆菌属菌株是使用NiFeSe氢化酶用于将氢(H2)转换成细胞能当量的菌株。
在一个实施方式中,在本发明的方法中使用的黄色杆菌属菌株是使用NAD+还原氢化酶用于将氢(H2)转换成细胞能当量的菌株。
在一个实施方式中,在本发明的方法中使用的黄色杆菌属菌株能够固氮。
在一个实施方式中,在本发明的方法中使用的细菌菌株选自:敏捷黄色杆菌(X.agilis)、氧化胺黄色杆菌(X.aminoxidans)、自养黄色杆菌(X.autotrophicus)、黄黄色杆菌(X.flavus)、万寿菊黄色杆菌(X.tagetidis)、粘黄色杆菌(X.viscosus)、黄色杆菌属sp.126、黄色杆菌属sp.91和菌株VTT-E-193585。
在一个优选的实施方式中,在本发明的方法中使用的细菌菌株是VTT-E-193585或万寿菊黄色杆菌。最优选地,在本发明的方法中使用的菌株是VTT-E-193585。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含SEQ ID NO:1中所示的16S核糖体RNA,或者与SEQ ID NO:1具有至多20个核苷酸差异,例如与SEQ ID NO:1有1至10,例如1至5,例如1、2或3个核苷酸差异的16S核糖体RNA。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码核酮糖-1,5-二磷酸羧化酶/加氧酶(rubisco)大链的基因,其具有SEQ ID NO:3中所示的序列,或者与SEQ ID NO:3中所示的序列具有多于93%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%的一致性,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码核酮糖-1,5-二磷酸羧化酶/加氧酶(rubisco)小链的基因,其具有SEQ ID NO:5中所示的序列,或者与SEQ ID NO:5中所示的序列具有多于83%的一致性,例如多于86%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%的一致性,例如多于99%的序列一致性的序列。
SEQ ID NO:2:
核酮糖二磷酸羧化酶大链的核苷酸序列:
ATGGGTGCCGAAGCAACCGTCGGGCAGATCACGGACGCCAAGAAGAGATACGCCGCCGGCGTGCTGAAGTACGCCCAGATGGGCTACTGGAACGGCGACTACGTTCCCAAGGACACCGACCTCCTGGCGGTGTTCCGCATCACCCCCCAGGCGGGCGTGGACCCGGTGGAAGCCGCCGCGGCGGTCGCCGGCGAAAGCTCCACCGCTACCTGGACCGTGGTGTGGACCGACCGGCTCACCGCCGCCGACGTCTACCGCGCCAAGGCCTACAAGGTGGAGCCGGTGCCGGGCCAGGAAGGCCAGTATTTCTGCTACATCGCCTATGATCTCGATTTGTTCGAGGAAGGCTCCATCGCCAACCTCACGGCGTCGATCATCGGCAACGTCTTCTCCTTCAAGCCGCTGAAGGCGGCGCGGCTGGAGGACATGCGGCTTCCCGTCGCCTATGTGAAGACCTTCCGCGGCCCGCCCACCGGCATCGTGGTCGAGCGCGAGCGCCTGGACAAGTTCGGCCGCCCCCTTCTGGGCGCCACCACCAAGCCGAAGCTTGGCCTCTCGGGCAAGAATTACGGCCGCGTGGTCTATGAGGCCCTCAAGGGCGGCCTCGACTTCGTGAAGGACGACGAGAACATCAACTCGCAGCCCTTCATGCACTGGCGCGATCGCTTCCTCTATTGCATGGAGGCCGTCAACAAGGCCCAGGCCGAGACCGGCGAGGTGAAGGGGCACTATCTCAACATCACCGCCGGGACCATGGAGGAGATGTACCGCCGCGCCGAGTTCGCCAAGGAACTGGGCTCCGTGGTGGTGATGGTGGATCTCATCATCGGCTGGACCGCCATCCAGTCCATGTCCAACTGGTGCCGCGAGAACGACATGATCCTGCACATGCACCGTGCGGGCCATGGCACCTACACGCGCCAGAAGAGCCACGGCGTCTCCTTCCGCGTCATCGCCAAGTGGCTGCGGCTCGCCGGCGTCGACCACCTGCACACCGGCACCGCCGTGGGCAAGCTGGAAGGCGACCCCATGACCGTGCAGGGCTTCTACAATGTCTGCCGCGAGACGACGACGCAGCAGGACCTCACCCGCGGCCTGTTCTTCGAGCAGGACTGGGGCGGCATCCGCAAGGTGATGCCGGTGGCCTCCGGCGGCATCCATGCGGGCCAGATGCACCAGCTCATCGACCTGTTCGGCGAGGACGTGGTGCTCCAGTTCGGCGGCGGCACCATCGGCCACCCGGACGGCATCCAGGCCGGCGCCACCGCCAACCGCGTGGCGCTGGAAACCATGATCCTCGCCCGCAACGAGGGCCGCGACATCAGGAACGAGGGCCCGGAAATCCTGGTGGAAGCCGCCAAATGGTGCCGTCCGCTGCGCGCGGCGCTCGATACCTGGGGCGAGGTGACCTTCAACTACGCCTCCACCGACACGTCCGATTACGTGCCCACCGCGTCCGTCGCCTGA
SEQ ID NO:3:
核酮糖二磷酸羧化酶大链的氨基酸序列
MGAEATVGQITDAKKRYAAGVLKYAQMGYWNGDYVPKDTDLLAVFRITPQAGVDPVEAAAAVAGESSTATWTVVWTDRLTAADVYRAKAYKVEPVPGQEGQYFCYIAYDLDLFEEGSIANLTASIIGNVFSFKPLKAARLEDMRLPVAYVKTFRGPPTGIVVERERLDKFGRPLLGATTKPKLGLSGKNYGRVVYEALKGGLDFVKDDENINSQPFMHWRDRFLYCMEAVNKAQAETGEVKGHYLNITAGTMEEMYRRAEFAKELGSVVVMVDLIIGWTAIQSMSNWCRENDMILHMHRAGHGTYTRQKSHGVSFRVIAKWLRLAGVDHLHTGTAVGKLEGDPMTVQGFYNVCRETTTQQDLTRGLFFEQDWGGIRKVMPVASGGIHAGQMHQLIDLFGEDVVLQFGGGTIGHPDGIQAGATANRVALETMILARNEGRDIRNEGPEILVEAAKWCRPLRAALDTWGEVTFNYASTDTSDYVPTASVA
SEQ ID NO:4:
核酮糖二磷酸羧化酶小链的核苷酸序列:
ATGCGCATCACCCAAGGCTCCTTCTCCTTCCTGCCGGACCTCACCGACACGCAGATCAAGGCCCAGGTGCAATATTGCCTGGACCAGGGCTGGGCGGTCTCGGTGGAGCACACCGACGATCCCCACCCGCGCAACACCTATTGGGAGATGTGGGGCCCGCCCATGTTCGATCTGCGCGACGCGGCCGGCGTCTTCGGCGAGATCGAAGCCTGCCGGGCCGCCAATCCCGAGCATTATGTGCGGGTGAACGCCTTCGATTCCAGCCGCGGATGGGAGACGATCCGCCTGTCCTTCATCGTTCAGCGGCCCACCGTGGAAGAGGGCTTCCGCCTCGACCGCACCGAAGGCAAGGGCCGCAACCAGAGCTACGCCATGCGCTACCGGGCGCAGTTCGCGCCGCGCTGA
SEQ ID NO:5:
核酮糖二磷酸羧化酶小链的氨基酸序列:
MRITQGSFSFLPDLTDTQIKAQVQYCLDQGWAVSVEHTDDPHPRNTYWEMWGPPMFDLRDAAGVFGEIEACRAANPEHYVRVNAFDSSRGWETIRLSFIVQRPTVEEGFRLDRTEGKGRNQSYAMRYRAQFAPR
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码NAD+还原氢化酶HoxS亚基α的基因,其具有SEQ ID NO:7中所示的序列,或者与SEQ ID NO:7中所示的序列具有多于70%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码NAD+还原氢化酶HoxS亚基β的基因,其具有SEQ ID NO:9中所示的序列,或者与SEQ ID NO:9中所示的序列具有多于77%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码NAD+还原氢化酶HoxS亚基γ的基因,其具有SEQ ID NO:11中所示的序列,或者与SEQ ID NO:11中所示的序列具有多于70%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码NAD+还原氢化酶HoxS亚基δ的基因,其具有SEQ ID NO:13中所示的序列,或者与SEQ ID NO:13中所示的序列具有多于79%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
SEQ ID NO:6:
NAD+还原氢化酶HoxS亚基α的核苷酸序列:
ATGATGCCATCTGAGCCGCACGGCGCGGGCATGCCGCCCCCACGGGAAGCGGCCGCGGTTCCCACCCCCCAGGAGGTGAGCGCGGTGGTGGCCGAGGTGGTCGCGGATGCCGTGGCATCGGTGGGCGGCGCACGCACCCGGCTCATGGACATCGTCCAGCTGGCCCAGCAGCGTCTCGGCCATCTCTCCGAAGAGACCATGGCGGCCATTGCCGCGCGGCTCGCCATTCCGCCGGTGGAAGTGGCGGACATGGTGTCCTTCTACGCCTTCCTGAACCGCGCGCCCAAGGGCCGCTACCACATCCGCCTGTCGCGCAGCCCCATCTCGCTGATGAAGGGCGCCGAGGCGGTGGCTGCCGCCTTCTGCCAGATCCTCGGCATCGCCATGGGCGAGACCTCGCAGGATGGCGACTTCACCCTGGAATGGACCAACGACATCGGCATGGCCGACCAGGAGCCGGCCGCCCTCGTCAACGGCACGGTGATGACGCAGCTCGCGCCCGGCGATGCGGCCATCATCGTCGGCCGGCTGCGGGCCCATCACGCGCCCAATGCCCTGCCGCTGTTCCCTGGAGCCGGCGTGGCCGGCTCCGGCCTGCCCCATGCCCGGATCCGCCCCAGCCTGGTGATGCCGGGACAGCTTCTGTTCCGCGAGGACCACACGACGCCGGGCGCCGGCATCAAGGCGGCACTCGCCCTCACCCCGGACGAAGTGGTGCAGAAGGTCTCCGCCGCGCGCCTGCGCGGGCGGGGTGGCGCCGGCTTTCCCACCGGTCTCAAATGGAAGCTCTGCCGCCAGTCGCCCGCCACCACCCGCCATGTGATCTGCAATGCGGACGAGGGCGAGCCCGGCACCTTCAAGGATCGCGTGCTGCTCACGCAGGCGCCGCACCTCATGTTCGACGGCATGACCATCGCCGGCTACGCCTTGGGGGCGCGGGAGGGCGTGGTCTATCTGCGCGGCGAGTACGCCTATCTGTGGGAGCCTCTGCATGCGGTCCTGCGCGAGCGCTATGGGCTCGGGCTCGCCGGCGCGAACATCCTGGGACACGCGGGCTTCGACTTCGACATCCGCATCCAGCTGGGCGCCGGCGCCTATATCTGCGGCGAGGAATCCGCGCTGGTGGAATCGCTGGAAGGCAAGCGCGGCTCGCCCCGCGACCGCCCCCCCTTCCCCACCGTGCGCGGCCATCTCCAGCAGCCCACCGCCGTGGACAATGTGGAGACCTTCGCCTGCGCCGCCCGCATCCTGGAGGATGGCGTGGAGGCGTTCGCGGGCATCGGCACGCCCGAATCCGCCGGCACGAAGCTCCTCTCGGTGTCGGGCGATTGCCCGCGCCCCGGCGTGTATGAGGTGCCCTTCGGCCTCACGGTGAACGCGCTGCTCGACCTTGTCGGCGCGCCGGACGCCGCCTTCGTGCAGATGGGTGGGCCGTCCGGCCAATGCGTGGCGCCGAAGGATTACGGCCGCCGCATCGCCTTCGAGGACCTGCCCACCGGCGGCTCGGTGATGGTGTTCGGCCCGGGGCGCGACGTGCTCGCCATGGTGCGCGAGTTCGCGGATTTCTTCGCCGGCGAATCCTGCGGCTGGTGCACGCCCTGCCGGGTGGGCACCACCTTGCTCAAGGAAGAGCTGGACAAGCTCCTCGCCAACCGCGCCACCCTCGCCGACATCCGCGCGCTGGAGACCCTGGCCACGACCGTCTCCCGCACCAGCCGCTGCGGCCTCGGCCAGACGGCGCCCAACCCCATCCTTTCCACCATGCGCAACCTGCCGGAAGCCTATGAGGCGAGGCTGAGGCCCGAAGACTTCCTGCCCTGGGCCTCGCTCGACGAGGCGCTGAAGCCCGCCATCGTCATCCAGGGCCGCGCGCCCGTGCCGGAGGAAGAGGCATGA
SEQ ID NO:7:
NAD+还原氢化酶HoxS亚基α的氨基酸序列:
MMPSEPHGAGMPPPREAAAVPTPQEVSAVVAEVVADAVASVGGARTRLMDIVQLAQQRLGHLSEETMAAIAARLAIPPVEVADMVSFYAFLNRAPKGRYHIRLSRSPISLMKGAEAVAAAFCQILGIAMGETSQDGDFTLEWTNDIGMADQEPAALVNGTVMTQLAPGDAAIIVGRLRAHHAPNALPLFPGAGVAGSGLPHARIRPSLVMPGQLLFREDHTTPGAGIKAALALTPDEVVQKVSAARLRGRGGAGFPTGLKWKLCRQSPATTRHVICNADEGEPGTFKDRVLLTQAPHLMFDGMTIAGYALGAREGVVYLRGEYAYLWEPLHAVLRERYGLGLAGANILGHAGFDFDIRIQLGAGAYICGEESALVESLEGKRGSPRDRPPFPTVRGHLQQPTAVDNVETFACAARILEDGVEAFAGIGTPESAGTKLLSVSGDCPRPGVYEVPFGLTVNALLDLVGAPDAAFVQMGGPSGQCVAPKDYGRRIAFEDLPTGGSVMVFGPGRDVLAMVREFADFFAGESCGWCTPCRVGTTLLKEELDKLLANRATLADIRALETLATTVSRTSRCGLGQTAPNPILSTMRNLPEAYEARLRPEDFLPWASLDEALKPAIVIQGRAPVPEEEA
SEQ ID NO:8:
NAD+还原氢化酶HoxS亚基β的核苷酸序列:
ATGAGCCGGGGATCCCCCGATGCCGGGAAAGACCGCACCATGAGCGCCACCGACGGCACCACCGCCCCCCGCAAGATCGTCATCGATCCGGTGACCCGCGTGGAGGGCCACGGCAAGGTCACCATCCGCCTGGATGAAGCCGGCGCGGTGGAGGATGCGCGTTTCCACATCGTGGAGTTCCGCGGCTTCGAGCGGTTCATCCAGGGCCGGATGTACTGGGAAGTGCCCCTTATCATCCAGCGGCTGTGCGGCATCTGCCCGGTGAGCCACCATCTGGCGGCGGCGAAAGCCATGGACCAGGTGGCGGGCGTGGACCGCGTACCGCCCACCGCCGAGAAACTGCGCCGGCTGATGCATTATGGGCAGGTGCTGCAATCCAACGCTTTGCACATCTTCCACCTCGCCTCGCCCGACCTCCTGTTCGGCTTCGACGCGCCGGCCGAGCAGCGCAACATCATCGCCGTGCTCCAGCGTTATCCGGAGATCGGCAAATGGGCGATCTTCATCAGGAAGTTCGGCCAGGAGGTCATCAAGGCCACCGGCGGGCGCAAGATCCATCCCACCAGCGCCATTCCCGGCGGGGTCAACCAGAACCTCGCCGTGGAGGACCGCGACGCCCTGCGCGCCAAGGTGGGCGAGATCATCAGCTGGTGCATGGCGGCGCTGGACCATCACAAGGCCTATGTGGCGGAAAACCGGGCGCTGCATGACAGCTTCGCCGCCTTCCCCTCCGCCTTCATGAGCCTCGTGGGGCCGGATGGCGGCATGGACCTTTATGACGGCACCCTGCGGGTGATCGATGCCGAGGGCGCCCCCCTCATCGAAGGCGCGCCGCCCGCCTCCTACCGCGACCACCTCATCGAGGAGGTGCGGCCCTGGAGCTATCTGAAATTCCCCCATCTGCGCGCCTTCGGCCGCGACGATGGCTGGTATCGGGTCGGCCCCCTCGCCCAGGTCAATTGCGCCGCGTCCATCGACACGCCCCGCGCCGAGGCGGCCCGGCGGGACTTCATGGCCGAGGGCGGCGGCAAGCCGGTGCATGCCACCCTCGCTTATCACTGGGCGCGGCTCATCGTGCTGGTCCATTGCGCGGAGAAGATCGAACAGCTGCTGTTCGACGACGACCTGCAAGGCTGCGATCTGCGTGCGGAGGGCACCCGGCGCGGGGAAGGCGTCGCCTGGATCGAGGCGCCGCGCGGCACCCTCATCCACCATTACGAGGTGGACGAGAACGACCAGGTGCGCCGCGCCAACCTCATCGTCTCCACCACCCACAATAACGAGGCCATGAACCGCGCCGTGCGGCAGGTGGCGAAGACGGACCTTTCCGGTCGCGAGATCACCGAAGGGCTGCTGAACCATATCGAGGTGGCCATCCGCGCCTTCGACCCCTGCCTGTCCTGCGCCACCCATGCGCTGGGCCAGATGCCGCTGATCGTGACGCTTGAAGATGCCTCCGGCGCAGAGATCGCCCGCGGAGTGAAGGAATGA
SEQ ID NO:9:
NAD+还原氢化酶HoxS亚基β的氨基酸序列:
MSRGSPDAGKDRTMSATDGTTAPRKIVIDPVTRVEGHGKVTIRLDEAGAVEDARFHIVEFRGFERFIQGRMYWEVPLIIQRLCGICPVSHHLAAAKAMDQVAGVDRVPPTAEKLRRLMHYGQVLQSNALHIFHLASPDLLFGFDAPAEQRNIIAVLQRYPEIGKWAIFIRKFGQEVIKATGGRKIHPTSAIPGGVNQNLAVEDRDALRAKVGEIISWCMAALDHHKAYVAENRALHDSFAAFPSAFMSLVGPDGGMDLYDGTLRVIDAEGAPLIEGAPPASYRDHLIEEVRPWSYLKFPHLRAFGRDDGWYRVGPLAQVNCAASIDTPRAEAARRDFMAEGGGKPVHATLAYHWARLIVLVHCAEKIEQLLFDDDLQGCDLRAEGTRRGEGVAWIEAPRGTLIHHYEVDENDQVRRANLIVSTTHNNEAMNRAVRQVAKTDLSGREITEGLLNHIEVAIRAFDPCLSCATHALGQMPLIVTLEDASGAEIARGVKE
SEQ ID NO:10:
NAD+还原氢化酶HoxS亚基γ的核苷酸序列:
ATGAGCGAGACCCCCTTCACCTTTACCGTGGACGGCATCGCGGTCCCGGCCACCCCCGGCCAGAGCGTCATCGAGGCGTGCGATGCGGCGGGCATCTATATCCCGCGCCTGTGCCACCACCCGGACCTGCCGCCGGCGGGCCATTGCCGGGTGTGCACCTGCATCATCGACGGGCGGCCGGCCAGCGCCTGCACCATGCCCGCCGCCAGGGGCATGGTGGTGGAGAACGAGACGCCCGCTTTGCTGGCGGAGCGGCGCACGCTGATCGAGATGCTGTTCGCGGAAGGCAACCATTTCTGCCAGTTCTGCGAGGCGAGCGGCGATTGCGAATTGCAGGCGCTGGGCTACCTGTTCGGCATGGTGGCCCCGCCCTTCCCCCATCTGTGGCCGAAGCGGCCGGTGGATGCCAGCCATCCGGATATCTATATCGACCACAATCGCTGCATCCTGTGCTCGCGCTGCGTGCGCGCCTCGCGCACCCTGGACGGCAAGTCCGTGTTCGGCTTCGAGGGGCGCGGCATCGAGATGCATCTGGCGGTGACCGGCGGGCACCTGGACGACAGCGCCATCGCCGCCGCCGACAGGGCGGTTGAGATGTGCCCGGTGGGCTGCATCGTCCTCAAGCGCACCGGCTACCGCACGCCCTATGGCCGGCGGCGCTACGACGCCGCGCCCATCGGCTCCGACATCACCGCCCGGCGCGGCGGCGCGAAGGACTGA
SEQ ID NO:11:
NAD+还原氢化酶HoxS亚基γ的氨基酸序列:
MSETPFTFTVDGIAVPATPGQSVIEACDAAGIYIPRLCHHPDLPPAGHCRVCTCIIDGRPASACTMPAARGMVVENETPALLAERRTLIEMLFAEGNHFCQFCEASGDCELQALGYLFGMVAPPFPHLWPKRPVDASHPDIYIDHNRCILCSRCVRASRTLDGKSVFGFEGRGIEMHLAVTGGHLDDSAIAAADRAVEMCPVGCIVLKRTGYRTPYGRRRYDAAPIGSDITARRGGAKD
SEQ ID NO:12:
NAD+还原氢化酶HoxS亚基δ的核苷酸序列:
ATGGCCAAGCCCAAACTCGCCACCTGCGCGCTGGCCGGCTGCTTCGGCTGCCACATGTCCTTCCTGGACATGGACGAGCGCATCGTCGAGCTCATCGACCTGGTGGACCTCGACGTCTCGCCCCTCGACGACAAGAAAAACTTCACCGGCATGGTGGAAATCGGCCTGGTGGAAGGCGGCTGCGCCGACGAGCGCCATGTGAAGGTGCTGCGCGAGTTCCGCGAGAAATCCCGCATCCTGGTGGCGGTGGGCGCCTGCGCCATCACCGGCGGCATCCCGGCATTGCGCAACCTCGCCGGCCTCGACGAATGCCTGAGGGAAGCCTACCTCACCGGCCCCACGGTGGAAGGCGGCGGGCTCATTCCCAACGACCCGGAGCTGCCGCTGCTGCTGGACAAGGTCTATCCGGTGCAGGACTTCGTGAAGATCGACCATTTCCTGCCCGGCTGCCCGCCCTCGGCCGACGCCATCTGGGCGGCTCTGAAGGCGCTGCTGACCGGCACCGAGCCGCATCTGCCCTACCCGCTTTTCAAGTACGAATGA
SEQ ID NO:13:
NAD+还原氢化酶HoxS亚基δ的氨基酸序列:
MAKPKLATCALAGCFGCHMSFLDMDERIVELIDLVDLDVSPLDDKKNFTGMVEIGLVEGGCADERHVKVLREFREKSRILVAVGACAITGGIPALRNLAGLDECLREAYLTGPTVEGGGLIPNDPELPLLLDKVYPVQDFVKIDHFLPGCPPSADAIWAALKALLTGTEPHLPYPLFKYE
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码NiFeSe氢化酶大亚基的基因,其具有SEQ ID NO:15中所示的序列,或者与SEQ ID NO:15中所示的序列具有多于84%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码NiFeSe氢化酶小亚基的基因,其具有SEQ ID NO:17中所示的序列,或者与SEQ ID NO:17中所示的序列具有多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
SEQ ID NO:14:
周质[NiFeSe]氢化酶大亚基的核苷酸序列:
TCCAGACCCGGGCAACATTGCTCCATGTGCTGGGCACCCTGGCCGGCCGCTGGCCCCATACCCTCGCGCTCCAGCCCGGCGGGGTGACCCGAAGCGCCGACCAGCACGACCGCATGCGCCTGCTCGCGACGCTGAAGGCGGTGCGGGCGGCGCTGGAAGAGACCTTGTTCGGCGCGCCTTTGGAAGAGGTGGCGGCCCTGGACGGCGCCGCCGCCGTGGAGGCCTGGCGCGCCAACGGCCCGGAAGGGGATTTCCGCCTGTTCCTGGAGATCGCCGCCGACCTGGAGCTGGACCGGCTCGGCCGCGCGCACGACCGCTTTCTCTCCTTCGGCGCCTACGCCCAGGACGAGGGGCGCCTTTATGGCGCCGGCACCTTCGAGGCCGGGACGGCGGGAGGGCTCGATCCCAACGCCATCACCGAGGACCACGCCTTCGCCCGCATGGAGGACCGCGCGGCGCCCCATGCGCCCTTTGACGGCTCCACCTTCCCCGATGCCGACGACACCGAGGGCTACACCTGGTGCAAGGCGCCGCGCCTTGCCGGCCTGCCCTTCGAGACCGGCGCCTTCGCCCGGCAGGTGGTGGCGGGCCATCCGCTCGCCCGGGACCTCGTGACGCGGGAAGGCGGCACTGTGCGCAGCCGCGTGGTCGGCCGGCTGCTGGAAACCGCGCGCACCCTGATCGCCATGGAGGGCTGGGTGAAGGAACTGCGGCCCGAAGGGCCCTGGTGCGCCCAGGGCCACCTGCCCCAGGAAGGCCGCGCCTTCGGCCTCACCGAGGCGGCGCGCGGGGCGCTCGGCCACTGGATGGTGGTGGAGAAGGGCCGCATTGCCCGCTACCAGATCATCGCCCCCACCACCTGGAACTTCTCCCCCCGCGACGGCGCGGGCCTGCCCGGCCCGCTGGAGACGGCCCTGGTGGGCGCGCCCGTGCGGCAGGGAGAGACGACGCCCGTGAGCGTGCAGCACATCGTGCGCTCCTTCGACCCGTGCATGGTCTGCACTGTGCATTGA
SEQ ID NO:15:
周质[NiFeSe]氢化酶大亚基的氨基酸序列:
MSAETRRLVVGPFNRVEGDLEVRLDVQDGRVQQAFVSSPLFRGFERILEGRDPRDALVIAPRICGICSVSQSHAAALALAGLQGIAPTHDGRIATNLIVAAENVADHLTHFHVFFMPDFARAVYEDRPWFAQAARRFKANQGVSVRRALQTRATLLHVLGTLAGRWPHTLALQPGGVTRSADQHDRMRLLATLKAVRAALEETLFGAPLEEVAALDGAAAVEAWRANGPEGDFRLFLEIAADLELDRLGRAHDRFLSFGAYAQDEGRLYGAGTFEAGTAGGLDPNAITEDHAFARMEDRAAPHAPFDGSTFPDADDTEGYTWCKAPRLAGLPFETGAFARQVVAGHPLARDLVTREGGTVRSRVVGRLLETARTLIAMEGWVKELRPEGPWCAQGHLPQEGRAFGLTEAARGALGHWMVVEKGRIARYQIIAPTTWNFSPRDGAGLPGPLETALVGAPVRQGETTPVSVQHIVRSFDPCMVCTVH
SEQ ID NO:16:
周质[NiFeSe]氢化酶小亚基的核苷酸序列
ACGGGGGAGGAAGCCCGCGCCATCTTCGACGCCATCCTTGCCGGCGTTATCGTCCTCGACGCCCTGTGCGTGGAAGGCGCGCTGCTGCGCGGGCCGAACGGCACCGGGCGCTTCCATGTGCTGGCGGGCACGGACACCCCCACCATCGACTGGGCGCGGCAGCTCGCCGGCATGGCGCGCCACGTGGTGGCGGTGGGCACCTGCGCCGCCTATGGGGGCGTGACGGCGGCGGGCATCAACCCCACCGATGCCTGCGGCCTCCAGTTCGACGGACGCCGGAAGGGTGGGGCGCTGGGGGCGGACTTCCGCTCCCGCTCGGGGCTTCCGGTCATCAATGTGGCCGGCTGCCCCACCCATCCCAACTGGGTGACGGAAACCCTGATGCTGCTCGCCTGCGGCCTGCTGGGCGAGGCCGACCTCGACGTCTATGGCCGCCCGCGCTTCTATGCGGACCTGCTGGTGCATCACGGCTGCCCGCGCAACGAATACTATGAATACAAGGCGAGCGCCGAGAAGATGAGCGACCTCGGCTGCATGATGGAGCATCTGGGCTGCCTCGGCACCCAGGCCCACGCCGACTGCAACACGCGCCTTTGGAATGGCGAGGGCTCGTGCACCCGCGGCGGCTATGCCTGCATCAACTGCACGGCGCCGGAATTCGAGGAGCCGGGCCACGCCTTCCTGGAGACGCCCAAGATCGGCGGCATCCCCATCGGCCTGCCCACCGACATGCCCAAGGCCTGGTTCATCGCCTTGTCCTCCCTCGCCAAGGCGGCGACGCCGGAGCGGCTGCGCAAGAACGCGGTGTCCGACCATGTGGTCACGCCGCCCGCCGTCAAGGACATCAAGCGGCGATGA
SEQ ID NO:17:
周质[NiFeSe]氢化酶小亚基的氨基酸序列
MSTPFSVLWLQSGGCGGCTMSLLCAEAPDLATTLDAAGIGFLWHPALSEETGEEARAIFDAILAGVIVLDALCVEGALLRGPNGTGRFHVLAGTDTPTIDWARQLAGMARHVVAVGTCAAYGGVTAAGINPTDACGLQFDGRRKGGALGADFRSRSGLPVINVAGCPTHPNWVTETLMLLACGLLGEADLDVYGRPRFYADLLVHHGCPRNEYYEYKASAEKMSDLGCMMEHLGCLGTQAHADCNTRLWNGEGSCTRGGYACINCTAPEFEEPGHAFLETPKIGGIPIGLPTDMPKAWFIALSSLAKAATPERLRKNAVSDHVVTPPAVKDIKRR
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶γ链atpG_1的基因,其具有SEQ ID NO:19中所示的序列,或者与SEQ ID NO:19中所示的序列具有多于70%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基αatpA_1的基因,其具有SEQ ID NO:21中所示的序列,或者与SEQ ID NO:21中所示的序列具有多于78%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基batpF_1的基因,其具有SEQ ID NO:23中所示的序列,或者与SEQ ID NO:23中所示的序列具有多于62%的一致性,例如多于70%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基c,钠离子特异性atpE_1的基因,其具有SEQ ID NO:25中所示的序列,或者与SEQ ID NO:25中所示的序列具有多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基aatpB_1的基因,其具有SEQ ID NO:27中所示的序列,或者与SEQ ID NO:27中所示的序列具有多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶ε链atpC_1的基因,其具有SEQ ID NO:29中所示的序列,或者与SEQ ID NO:29中所示的序列具有多于71%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基βatpD_1的基因,其具有SEQ ID NO:31中所示的序列,或者与SEQ ID NO:31中所示的序列具有多于84%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基βatpD_2的基因,其具有SEQ ID NO:33中所示的序列,或者与SEQ ID NO:33中所示的序列具有多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶γ链atpG_2的基因,其具有SEQ ID NO:35中所示的序列,或者与SEQ ID NO:35中所示的序列具有多于86%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基αatpA_2的基因,其具有SEQ ID NO:37中所示的序列,或者与SEQ ID NO:37中所示的序列具有多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基δatpH的基因,其具有SEQ ID NO:39中所示的序列,或者与SEQ ID NO:39中所示的序列具有多于85%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基batpF_2的基因,其具有SEQ ID NO:41中所示的序列,或者与SEQ ID NO:41中所示的序列具有多于87%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基b'atpG_3的基因,其具有SEQ ID NO:43中所示的序列,或者与SEQ ID NO:43中所示的序列具有多于81%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基catpE_2的基因,其具有SEQ ID NO:45中所示的序列,或者与SEQ ID NO:45中所示的序列具有多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶亚基aatpB_2的基因,其具有SEQ ID NO:47中所示的序列,或者与SEQ ID NO:47中所示的序列具有多于92%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码ATP合酶蛋白IatpI的基因,其具有SEQ ID NO:49中所示的序列,或者与SEQ ID NO:49中所示的序列具有多于60%的一致性,例如多于70%的一致性,例如多于80%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
SEQ ID NO:18:
ATP合酶γ链atpG_1的核苷酸序列
GTGACCGAGCGCCTGTCCGACGTCAACGCCCGCATCGCCTCGGTGCGGCAGCTCTCATCGGTCATCACGGCCATGCGGGGCATTGCGGCGGCGCGGGCGCGGGAGGCGCGGGGTCGGCTCGACGGCATCCGCGCCTATGCGCAGACCATCGCCGAGGCCATCGGCCATGTGCTCGCCGTGCTGCCCGAGGAGGCCCGCGCCCGGTCCTCCGGGCACCGGCATCGGGGCCATGCGGTCATCGCCCTGTGCGCGGAGCAGGGCTTTGCCGGCGTCTTCAACGAGCGGGTGCTGGACGAGGCCGCCCGGCTGCTGACCGGCGGGGCGGGGCCGGCCGAGCTGCTGCTGGTGGGCGACCGGGGCCTGATGGTGGCCCGCGAGCGGGGGCTCGATGTCTCCTGGTCGGTGCCCATGGTGGCCCATGCGGGCCAGGCCTCGGCGCTGGCGGACCGCATCAGCGAGGAGCTCTACCGGCGGATCGATGCGGGACGGGTGACGCGGGTGTCGGTGGTGCACGCCGAGCCCGCCGCGTCCGCCGCCATCGAGACGGTGGTGAAAGTGCTGGTGCCGTTCGACTTCGCCCGCTTCCCCCTGGCGCGGGTGGCATCCGCCCCGCTCATGACCATGCCGCCGCCGCGGCTGCTGGCCCAGCTGTCGGAGGAATATGTGTTCGCCGAGCTGTGCGAGGCGCTCACCTTGTCCTTCGCGGCGGAGAACGAGGCCCGCATGCGGGCCATGATCGCCGCCCGCGCCAATGTGGCCGATACCCTGGAGGGCCTCGTCGGCCGCGCCCGGCAGATGCGCCAGGAGGAGATCACCAACGAGATCATCGAGCTGGAAGGCGGCGCCGGCAGCGCCCGGCATGCGGATTGA
SEQ ID NO:19:
ATP合酶γ链atpG_1的氨基酸序列
MTERLSDVNARIASVRQLSSVITAMRGIAAARAREARGRLDGIRAYAQTIAEAIGHVLAVLPEEARARSSGHRHRGHAVIALCAEQGFAGVFNERVLDEAARLLTGGAGPAELLLVGDRGLMVARERGLDVSWSVPMVAHAGQASALADRISEELYRRIDAGRVTRVSVVHAEPAASAAIETVVKVLVPFDFARFPLARVASAPLMTMPPPRLLAQLSEEYVFAELCEALTLSFAAENEARMRAMIAARANVADTLEGLVGRARQMRQEEITNEIIELEGGAGSARHAD
SEQ ID NO:20:
ATP合酶亚基αatpA_1的核苷酸序列
ATGAGCACGGGCGCGCAAGCGAGCGAGGATTGGCTCACCCGGAGCCGGGCGGCCCTGGCCGGGACGCGCCTTTCCCAGCAATCCCAATCGGTGGGCCGGGTGGAGGAGATGGCCGACGGCATCGCCCGCGTCTCCGGCCTGCCGGATGTGCGGCTCGACGAGCTTCTCACCTTCGAGGGCGGCCAGACCGGCTATGCCCTCACCCTCGATCGCACCGAGATCGCCGTGGTGCTGCTGGATGACGCCTCCGGCGTGGAGGCGGGCGCCCGGGTGTTCGGCACCGGCGAGGTGGTGAAGGTGCCGGTGGGGCCGGGGCTGCTGGGCCGCATCGTCGACCCCCTCGGCCGGCCCATGGACCGCTCCGAGCCGGTGGTGGCGCAGGCGCACCATCCCATCGAGCGGCCGGCGCCGGCCATCATCGCCCGCGACCTGGTCTCGCAGCCGGTTCAGACCGGCACGCTGGTGGTGGATGCGCTGTTCTCCCTCGGCCGGGGCCAGCGCGAGCTCATCATCGGCGACCGGGCTACCGGCAAGACCGCCATCGCGGTGGACACCATCATCAGCCAGAAGCATTCGGACATCGTGTGCATCTACGTGGCGGTGGGCCAGCGCGCCGCCGCCGTGGAGCGGGTGGTGGAGGCGGTGCGCGCCCACGGGGCGATCGAGCGCTGCATCTTCGTGGTCGCCTCGGCCGCCGCCTCGCCAGGGCTGCAATGGATCGCGCCGTTCGCCGGCATGACCATGGCGGAATATTTCCGCGACAACGGCCAGCATGCGCTCATCATCATCGATGATCTCACCAAGCATGCGGCCACCCATCGCGAGCTGGCGCTGCTCACCCACGAGCCGCCGGGCCGCGAGGCCTATCCCGGCGACATCTTCTATGTGCACGCCCGCCTTCTGGAGCGGGCCGCCAAGCTCTCCGCCGAGCTGGGCGGTGGCTCGCTCACGGCCCTGCCCATCGCGGAGACGGACGCGGGAAACCTCTCCGCCTATATCCCCACCAACCTCATCTCCATCACCGATGGGCAGATCGTGCTGGATTCGCGGCTGTTCGCGGCCAACCAGCGCCCGGCGGTGGATGTGGGCCTCTCCGTGAGCCGGGTGGGCGGCAAGGCGCAGCATCCCGCGCTTCGGGCCGTGTCCGGGCGCATCCGGCTCGATTATTCCCAGTTCCTGGAGCTGGAAATGTTCACCCGCTTCGGCGGCATCACCGATACCCGCGTGAAGGCGCAGATCACCCGGGGCGAGCGCATCCGCGCGCTGCTCACCCAGCCGCGCTTTTCCACCCTGCGCCTTCAGGACGAGGTGGCGCTGCTGGCCGCGCTGGCGGAGGGGGTGTTCGACACTTTGGCCCCGGGGCTGATGGGCGCCGTGCGTGCCCGCATTCCGGCCCAGCTGGATGCGCAGGTGAAGGACGTGGCCTCGGCCCTCGCCGAGGGCAAGGTGCTGGAGGAGGGCTTGCACGCCCGTCTCGTGGCGGCCGTGCGGGCCGTCGCGGCGGACGTGGCCGCGACCGCGAAGGCCGGGCCGTGA
SEQ ID NO:21:
ATP合酶亚基αatpA_1的氨基酸序列
MSTGAQASEDWLTRSRAALAGTRLSQQSQSVGRVEEMADGIARVSGLPDVRLDELLTFEGGQTGYALTLDRTEIAVVLLDDASGVEAGARVFGTGEVVKVPVGPGLLGRIVDPLGRPMDRSEPVVAQAHHPIERPAPAIIARDLVSQPVQTGTLVVDALFSLGRGQRELIIGDRATGKTAIAVDTIISQKHSDIVCIYVAVGQRAAAVERVVEAVRAHGAIERCIFVVASAAASPGLQWIAPFAGMTMAEYFRDNGQHALIIIDDLTKHAATHRELALLTHEPPGREAYPGDIFYVHARLLERAAKLSAELGGGSLTALPIAETDAGNLSAYIPTNLISITDGQIVLDSRLFAANQRPAVDVGLSVSRVGGKAQHPALRAVSGRIRLDYSQFLELEMFTRFGGITDTRVKAQITRGERIRALLTQPRFSTLRLQDEVALLAALAEGVFDTLAPGLMGAVRARIPAQLDAQVKDVASALAEGKVLEEGLHARLVAAVRAVAADVAATAKAGP
SEQ ID NO:22:
ATP合酶亚基b atpF_1的核苷酸序列
ATGCAGATCGACTGGTGGACGCTGGGCCTGCAGACGGTCAACGTCCTCGTTCTCATCTGGCTCCTGAGCCGCTTCCTGTTCAAGCCGGTGGCGCAGGTCATCGCGCAGCGCCGTGCCGAGATCGAGAAGCTGGTGGAGGATGCGCGCGCCGCCAAGGCCGCCGCCGAGGCCGAGCGGGACACGGCGAAGGCGGAGGAGGCGCGCCTTGCCGCCGAGCGCGGCGCCCGCATGGCGGCGGTCGCCAAGGAGGCGGAGGCGCAGAAGGCGGCATTGCTGGCCGCCGCCAAGACCGAGGCCGAGGCCCTGCACGCGGCCGCGGAAGCGGCCATCGTCCGGGCGCGGGCGAGCGAGGAGGAAGCCGCCGCCGACCGCGCCAGCCGCCTTGCCGTGGACATCGCCGCCAAGCTGCTGGACCGGCTGCCCGACGACGCCCGGGTCGCGGGCTTCATCGATGGCCTCGCCGAGGGGCTTGAAGCCCTGCCCGAGGCGAGCCGGGCGGTGATCGGCGTCGACGGCGCGCCAGTGCGCGTGACGGCCGCGCGCGCCCTTATGCCGGCGGAGGAGGAGGCCTGCCGCACGCGGCTCTCCCAGGCGCTGGGCCGTCCGGTGACGCTGGCCGTGACCATCGACCCCGCCCTCATCGCCGGCCTGGAGATGGAGACGCCCCACGCGGTGGTGCGCAATTCCTTCAAGGCCGATCTCGACCGCGTCACCGCGGCGCTCACCCATCATGGGACCTGA
SEQ ID NO:23:
ATP合酶亚基b atpF_1的氨基酸序列
MQIDWWTLGLQTVNVLVLIWLLSRFLFKPVAQVIAQRRAEIEKLVEDARAAKAAAEAERDTAKAEEARLAAERGARMAAVAKEAEAQKAALLAAAKTEAEALHAAAEAAIVRARASEEEAAADRASRLAVDIAAKLLDRLPDDARVAGFIDGLAEGLEALPEASRAVIGVDGAPVRVTAARALMPAEEEACRTRLSQALGRPVTLAVTIDPALIAGLEMETPHAVVRNSFKADLDRVTAALTHHGT
SEQ ID NO:24:
ATP合酶亚基c,钠离子特异性atpE_1的核苷酸序列
ATGACTGTCGAGATGGTCAGCATCTTCGCGGCGGCGCTCGCCGTCTCCTTCGGCGCCATCGGGCCGGCCCTGGGCGAGGGCCGGGCGGTGGCCGCGGCCATGGACGCCATCGCCCGCCAGCCGGAGGCGGCCGGAACCTTGTCGCGCACGCTCTTCGTCGGCCTCGCCATGATCGAGACCATGGCGATCTACTGCCTGGTGATCGCGCTCCTGGTGCTCTTCGCCAATCCGTTCGTGAAGTGA
SEQ ID NO:25:
ATP合酶亚基c,钠离子特异性atpE_1的氨基酸序列
MTVEMVSIFAAALAVSFGAIGPALGEGRAVAAAMDAIARQPEAAGTLSRTLFVGLAMIETMAIYCLVIALLVLFANPFVK
SEQ ID NO:26:
ATP合酶亚基a atpB_1的核苷酸序列
ATGGGCTCGCCGCTGATCCTCGAACCCCTGTTCCATATCGGGCCCGTGCCCATCACCGCGCCGGTGGTGGTCACCTGGCTCATCATGGCCGCCTTCATTGGGCTGGCGCGGCTCATCACCCGGAAGCTTTCCACCGATCCCACCCGGACCCAGGCGGCGGTGGAAACGGTGCTGACCGCCATCGATTCCCAGATCGCCGACACCATGCAGGCCGATCCCGCGCCTTATCGCGCGCTCATCGGCACCATCTTCCTTTATGTGCTGGTGGCCAACTGGTCCTCGCTCATCCCGGGCATCGAGCCGCCCACGGCGCATATCGAGACCGATGCGGCGCTCGCTTTCATCGTGTTCGCCGCCACCATCGGGTTCGGGTTGAAGACAAGGGGTGTGAAGGGCTATCTCGCCACCTTCGCCGAACCCTCCTGGGTGATGATCCCGCTCAATGTGGTGGAGCAGATCACCCGGACCTTCTCGCTCATCGTGCGCCTGTTCGGCAACATCATGAGCGGGGTGTTCGTGGTCGGCATCATCCTGTCCCTCGCCGGGCTGCTGGTGCCCATCCCCCTCATGGCGCTCGATCTCCTGACCGGCGCCGTGCAGGCCTACATCTTCGCGGTGCTGGCCTGCGTGTTCATCGGCGCGGCCATTGGCGAGGCGCCGGCAAAGCCCCAATCGAAGGAGCCAGGGAAAACATCATGA
SEQ ID NO:27:
ATP合酶亚基a atpB_1的氨基酸序列
MGSPLILEPLFHIGPVPITAPVVVTWLIMAAFIGLARLITRKLSTDPTRTQAAVETVLTAIDSQIADTMQADPAPYRALIGTIFLYVLVANWSSLIPGIEPPTAHIETDAALAFIVFAATIGFGLKTRGVKGYLATFAEPSWVMIPLNVVEQITRTFSLIVRLFGNIMSGVFVVGIILSLAGLLVPIPLMALDLLTGAVQAYIFAVLACVFIGAAIGEAPAKPQSKEPGKTS
SEQ ID NO:28:
ATP合酶ε链atpC_1的核苷酸序列
GTGAGCGCGCCGCTGCACCTCACCATCACCACGCCGGCCGCCGTTCTGGTGGACCGTGCCGACATCGTGGCCCTGCGTGCCGAGGACGAGAGCGGCAGCTTCGGCATCCTGCCCGGCCATGCGGATTTCCTGACCGTTCTGGAGGCCTGCGTGGTGCGCTTCAAGGATGGGGCCGACGGCGTGCATTATTGTGCTCTCAGTGGTGGCGTGCTGTCGGTCGAGGAGGGCCGGCGCATCGCCATCGCCTGCCGTCAGGGCACGGTGAGCGACGACCTGGTCGCCCTGGAAGGGGCGGTGGACGCCATGCGTTCGGCGGAGAGCGATGCCGACAAGCGGGCCCGGGTGGAGCAGATGCGCCTTCATGCCCACGCCGTGCGCCAGCTCCTGCACTATCTGCGGCCCGGCCGGGCCGGCGGCGTGGCGCCGGCCGCCGCGCCGGAGGAGGGGCCGTCATGA
SEQ ID NO:29:
ATP合酶ε链atpC_1的氨基酸序列
MSAPLHLTITTPAAVLVDRADIVALRAEDESGSFGILPGHADFLTVLEACVVRFKDGADGVHYCALSGGVLSVEEGRRIAIACRQGTVSDDLVALEGAVDAMRSAESDADKRARVEQMRLHAHAVRQLLHYLRPGRAGGVAPAAAPEEGPS
SEQ ID NO:30:
ATP合酶亚基βatpD_1的核苷酸序列
ATGGCAGCGGCAGATGAGGAGGCGCAATCGGCCGCCGGCCCCGCCTCGGGCCGGGTGGTGGCCGTGCGCGGCGCGGTGATCGACATCGCCTTTGCCCAGCCTCCGCTGCCGCCGCTGGACGACGCCCTTCTCATCACCGACGGCCGGGGCGGCACGGTGCTGGTGGAGGTGCAGAGCCATATGGATCGGCACACGGTGCGCGCCATCGCCCTTCAGGCCACCACCGGCCTCAGCCGGGGGCTGGAGGCGGCGCGGGTGGGCGGGCCGGTGAAGGTGCCGGTGGGAGACCATGTGCTCGGCCGCCTCCTGGATGTCACCGGCGCCATCGGCGACAAGGGCGGGCCGCTGCCGGCCGACGTGCCCACGCGGCCGATCCACCACGCGCCGCCATCCTTCGCCGCGCAGGGCGGCACGTCCGATCTGTTTCGCACCGGCATCAAGGTCATCGACCTCCTGGCGCCCCTCGCCCAGGGCGGCAAGGCGGCCATGTTCGGCGGGGCCGGCGTGGGCAAGACCGTGCTGGTGATGGAGCTGATCCACGCCATGGTGGCGAGCTACAAGGGCATCTCGGTGTTTGCCGGCGTGGGGGAGCGCTCCCGCGAGGGCCACGAGATGCTGCTGGACATGACCGATTCCGGCGTGCTCGACCGCACCGTTCTGGTCTATGGCCAGATGAACGAGCCCCCCGGGGCCCGCTGGCGGGTGCCCATGACGGCGCTGACCATCGCCGAATATTTCCGCGACGAGAAGCACCAGAACGTCCTGCTGCTGATGGACAACATCTTCCGCTTCGTCCAGGCGGGGGCGGAGGTCTCCGGCCTTTTGGGCCGTCCGCCCTCCCGGGTGGGATACCAGCCGACGCTGGCGAGCGAGGTGGCGGCGCTCCAGGAACGCATCACCTCCGTGGGCGAGGCCTCGGTGACCGCCATCGAGGCGGTCTACGTGCCGGCGGATGACTTCACCGATCCCGCCGTGACCACCATCGCCGCCCACGTGGATTCCATGGTGGTGCTCTCCCGCGCCATGGCGGCGGAGGGCATGTATCCGGCGGTGGACCCCATCTCCTCCTCGTCGGTGCTGCTCGACCCGCTCATCGTGGGGGACGAGCATGCGCGCGTCGCCAACGAGGTGCGCCGGACCATCGAGCATTATCGCGAGCTTCAGGATGTGATCTCGCTGCTGGGCATGGAGGAATTGGGCACCGAGGATCGCCGCATCGTGGAGCGGGCGCGCCGGCTCCAGCGCTTCCTCACCCAGCCCTTCACGGTCACCGAGGCCTTCACCGGCGTGCCCGGCCGCTCGGTGGCCATCGCCGACACCATCGCCGGCTGCAGGATGATCCTGTCCGGCGCCTGCGACGACTGGCAGGAAAGCGCCCTCTACATGGTGGGCACCATCGACGAGGCCCGCCAGAAGGAGGAGGCCGCTCGCGCCAAGGCGGGGCAGGGCGCCCCGGCCGGGACGGCAGCCGAGACGGCGGAGGCCGCCCCGTGA
SEQ ID NO:31:
ATP合酶亚基βatpD_1的氨基酸序列
MAAADEEAQSAAGPASGRVVAVRGAVIDIAFAQPPLPPLDDALLITDGRGGTVLVEVQSHMDRHTVRAIALQATTGLSRGLEAARVGGPVKVPVGDHVLGRLLDVTGAIGDKGGPLPADVPTRPIHHAPPSFAAQGGTSDLFRTGIKVIDLLAPLAQGGKAAMFGGAGVGKTVLVMELIHAMVASYKGISVFAGVGERSREGHEMLLDMTDSGVLDRTVLVYGQMNEPPGARWRVPMTALTIAEYFRDEKHQNVLLLMDNIFRFVQAGAEVSGLLGRPPSRVGYQPTLASEVAALQERITSVGEASVTAIEAVYVPADDFTDPAVTTIAAHVDSMVVLSRAMAAEGMYPAVDPISSSSVLLDPLIVGDEHARVANEVRRTIEHYRELQDVISLLGMEELGTEDRRIVERARRLQRFLTQPFTVTEAFTGVPGRSVAIADTIAGCRMILSGACDDWQESALYMVGTIDEARQKEEAARAKAGQGAPAGTAAETAEAAP
SEQ ID NO:32:
ATP合酶亚基βatpD_2的核苷酸序列
ATGGCGAACAAGGTCGGACGCATCACCCAGATCATCGGCGCCGTCGTCGACGTGCAGTTCGACGGGCATCTGCCGGCGATTCTCAACGCGATCGAGACCACCAACCAGGGCAACCGGCTGGTGCTCGAAGTGGCTCAGCATCTCGGCGAGAACACCGTGCGCTGCATCGCCATGGATGCCACTGAAGGCCTGGTGCGTGGCCAGGAGGTGGCCGACACCGATGCGCCCATCCAGGTGCCCGTGGGCGCCGCCACCCTCGGCCGCATCATGAACGTGATCGGCGAGCCGGTGGACGAGCTGGGCCCCATCGAGGGCGAAGCGCTGCGCGGCATCCATCAGCCGGCCCCCTCCTATGCGGAGCAGGCCACGGAAGCTGAGATCCTCGTCACCGGCATCAAGGTGGTGGATCTGCTGGCGCCCTATTCCAAGGGCGGCAAGGTGGGCCTGTTCGGCGGCGCCGGCGTGGGCAAGACCGTGCTCATCATGGAGCTGATCAACAACGTGGCCAAGGCGCACGGCGGCTATTCCGTGTTCGCCGGCGTGGGTGAGCGCACCCGCGAGGGCAACGACCTCTACCACGAGATGATCGAGTCCAACGTGAACAAGGACCCGCACGAGAACAATGGCTCGGCGGCCGGTTCCAAGTGCGCCCTGGTCTATGGCCAGATGAACGAGCCGCCCGGCGCCCGCGCCCGCGTGGCCCTCACCGGCCTCACCGTCGCCGAGCATTTCCGCGACCAGGGCCAGGACGTGCTGTTCTTCGTGGACAACATCTTCCGCTTCACCCAGGCGGGCTCCGAGGTGTCGGCGCTTCTCGGCCGCATCCCCTCGGCGGTGGGCTACCAGCCGACGCTGGCCACCGACATGGGCCAGCTGCAGGAGCGCATCACCACCACCACCAAGGGCTCCATCACCTCGGTGCAGGCCATCTACGTGCCGGCGGACGATCTGACCGATCCGGCGCCGGCCGCCTCCTTCGCCCATCTGGACGCCACCACGGTGCTGTCGCGCTCCATCGCGGAGAAGGGCATCTACCCGGCGGTGGATCCGCTGGACTCCACCTCGCGCATGCTGTCTCCCGCCATCCTCGGCGACGAGCACTACAACACCGCGCGCCAGGTGCAGCAGACCCTGCAGCGCTACAAGGCGCTCCAGGACATCATCGCCATCCTGGGCATGGACGAACTCTCCGAAGAGGACAAGCTCACCGTGGCCCGCGCCCGCAAGATCGAGCGCTTCCTCTCCCAGCCCTTCCACGTGGCCGAGGTGTTCACCGGTTCGCCCGGCAAGCTGGTCGACCTCGCCGACACCATCAAGGGCTTCAAGGGCCTGGTGGACGGCAAGTACGACTACCTGCCCGAGCAGGCCTTCTACATGGTGGGCACCATCGAAGAAGCCATCGAGAAGGGCAAGAAGCTGGCGGCCGAGGCGGCCTGA
SEQ ID NO:33:
ATP合酶亚基βatpD_2的氨基酸序列
MANKVGRITQIIGAVVDVQFDGHLPAILNAIETTNQGNRLVLEVAQHLGENTVRCIAMDATEGLVRGQEVADTDAPIQVPVGAATLGRIMNVIGEPVDELGPIEGEALRGIHQPAPSYAEQATEAEILVTGIKVVDLLAPYSKGGKVGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESNVNKDPHENNGSAAGSKCALVYGQMNEPPGARARVALTGLTVAEHFRDQGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGQLQERITTTTKGSITSVQAIYVPADDLTDPAPAASFAHLDATTVLSRSIAEKGIYPAVDPLDSTSRMLSPAILGDEHYNTARQVQQTLQRYKALQDIIAILGMDELSEEDKLTVARARKIERFLSQPFHVAEVFTGSPGKLVDLADTIKGFKGLVDGKYDYLPEQAFYMVGTIEEAIEKGKKLAAEAA
SEQ ID NO:34:
ATP合酶γ链atpG_2的核苷酸序列
ATGGCGAGTCTGAAGGACCTGAGAAACCGCATTGCCTCGGTGAAGGCGACGCAGAAGATCACCAAGGCGATGCAGATGGTCGCCGCGGCGAAGCTGCGTCGCGCCCAGGCGGCGGCTGAAGCGGCCCGTCCCTATGCGGAACGCATGGAGACGGTGCTCGGAAATCTTGCCTCCGGCATGGTGGTGGGCGCGCAGGCGCCTGTTCTCATGACCGGGACGGGCAAGAGCGACACCCACCTGCTGCTGGTGTGCACCGGCGAGCGCGGCCTGTGCGGCGCCTTCAACTCGTCCATCGTGCGCTTCGCCCGCGAGCGGGCGCAGCTGCTGCTGGCCGAGGGCAAGAAGGTGAAAATCCTGTGCGTGGGCCGCAAGGGCCACGAGCAGCTGCGCCGCATCTACCCGGACAACATCATCGACGTGGTGGACCTGCGCGCGGTGCGCAACATCGGCTTCAAGGAGGCCGACGCCATCGCCCGCAAGGTGCTGGCCCTGCTCGATGAAGGCGCATTCGACGTCTGCACGCTCTTCTACTCCCACTTCAGGAGCGTGATCGCCCAGGTGCCGACGGCCCAGCAGCTCATTCCGGCCACCTTCGACGAGCGGCCGGCCGTCGCCGATGCGCCGGTCTATGAATATGAGCCGGAGGAGGAGGAGATCCTCGCCGAGCTGCTGCCGCGCAACGTGGCGGTGCAGATCTTCAAGGCCCTCCTCGAGAACCAGGCTTCTTTCTATGGCTCCCAGATGAGCGCCATGGACAACGCCACGCGCAATGCGGGCGAGATGATCAAGAAGCAGACGCTCACCTACAACCGTACCCGCCAGGCCATGATCACGAAGGAACTCATCGAGATCATCTCCGGCGCCGAGGCCGTCTGA
SEQ ID NO:35:
ATP合酶γ链atpG_2的氨基酸序列
MASLKDLRNRIASVKATQKITKAMQMVAAAKLRRAQAAAEAARPYAERMETVLGNLASGMVVGAQAPVLMTGTGKSDTHLLLVCTGERGLCGAFNSSIVRFARERAQLLLAEGKKVKILCVGRKGHEQLRRIYPDNIIDVVDLRAVRNIGFKEADAIARKVLALLDEGAFDVCTLFYSHFRSVIAQVPTAQQLIPATFDERPAVADAPVYEYEPEEEEILAELLPRNVAVQIFKALLENQASFYGSQMSAMDNATRNAGEMIKKQTLTYNRTRQAMITKELIEIISGAEAV
SEQ ID NO:36:
ATP合酶亚基αatpA_2的核苷酸序列
ATGGACATTCGAGCCGCTGAAATCTCTGCCATCCTGAAAGAGCAGATCCAGAATTTCGGCCAGGAGGCGGAAGTCTCCGAGGTGGGTCAGGTTCTGTCCGTGGGTGACGGCATCGCGCGCGTCTACGGCCTCGACAACGTCCAGGCGGGCGAGATGGTCGAGTTCGAGAACGGCACGCGCGGCATGGCGCTGAACCTCGAGCTCGACAATGTCGGCATCGTGATCTTCGGTTCCGACCGCGAGATCAAGGAAGGCCAGACCGTCAAGCGGACCGGCGCCATCGTGGACGCCCCCGTCGGCAAGGGCCTGCTCGGCCGCGTCGTGGACGCTCTCGGCAACCCGATCGACGGCAAGGGCCCGATCATGTTCACCGAGCGTCGCCGGGTCGACGTGAAGGCGCCGGGCATCATCCCGCGCAAGTCGGTGCACGAGCCCATGCAGACCGGCCTGAAGGCCATCGATGCGCTCATCCCCATCGGCCGCGGCCAGCGCGAGCTCATCATCGGCGACCGCCAGACCGGCAAGACCGCCGTGGCGCTCGACTCGATCCTGAACCAGAAGCCCATCAACCAGGGCGACGACGAGAAGGCCAAGCTCTACTGCGTCTATGTCGCGGTGGGCCAGAAGCGTTCCACTGTCGCGCAGTTCGTGAAGGTGCTCGAGGAGCACGGCGCGCTGGAATATTCCATCGTCGTCGCCGCCACCGCCTCGGACGCGGCCCCCATGCAGTTCCTGGCGCCGTTCACCGGCACCGCCATGGGCGAGTATTTCCGCGACAACGGCATGCACGCCCTCATCATCCATGATGACCTGTCCAAGCAGGCCGTGGCCTACCGCCAGATGTCGCTGCTGCTGCGCCGCCCGCCGGGCCGCGAGGCCTATCCCGGCGATGTGTTCTACCTGCACTCCCGCCTCTTGGAGCGCGCCGCCAAGCTCAATGACGAGCACGGCGCCGGCTCGCTGACCGCCCTGCCGGTGATCGAGACCCAGGCCAACGACGTGTCGGCCTACATCCCGACCAACGTGATCTCCATCACCGACGGTCAGATCTTCCTTGAATCCGATCTGTTCTACCAGGGCATCCGCCCGGCGGTGAACGTGGGCCTGTCGGTGTCGCGCGTGGGCTCTTCGGCCCAGATCAAGGCGATGAAGCAGGTGGCCGGCAAGATCAAGGGCGAGCTCGCCCAGTATCGCGAGCTGGCGGCCTTCGCCCAGTTCGGTTCGGACCTGGACGCGGCCACCCAGAAGCTGCTGAACCGCGGCGCCCGCCTCACCGAGCTGCTGAAGCAGAGCCAGTTCTCGCCCCTCAAGGTGGAGGAGCAGGTGGCGGTGATCTATGCCGGCACCAATGGCTATCTCGATCCGCTGCCGGTCTCCAAGGTGCGCGAGTTCGAGCAGGGTCTGCTCCTGTCGCTGCGCTCGCAGCATCCGGAGATCCTGGACGCCATCCGCACGTCCAAGGAGCTTTCCAAGGACACCGCCGAGAAGCTGACGAAGGCCATCGACGCCTTCGCCAAGAGCTTCTCCTGA
SEQ ID NO:37:
ATP合酶亚基αatpA_2的氨基酸序列
MDIRAAEISAILKEQIQNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLELDNVGIVIFGSDREIKEGQTVKRTGAIVDAPVGKGLLGRVVDALGNPIDGKGPIMFTERRRVDVKAPGIIPRKSVHEPMQTGLKAIDALIPIGRGQRELIIGDRQTGKTAVALDSILNQKPINQGDDEKAKLYCVYVAVGQKRSTVAQFVKVLEEHGALEYSIVVAATASDAAPMQFLAPFTGTAMGEYFRDNGMHALIIHDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDEHGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLESDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGKIKGELAQYRELAAFAQFGSDLDAATQKLLNRGARLTELLKQSQFSPLKVEEQVAVIYAGTNGYLDPLPVSKVREFEQGLLLSLRSQHPEILDAIRTSKELSKDTAEKLTKAIDAFAKSFS
SEQ ID NO:38:
ATP合酶亚基δatpH的核苷酸序列
GTGGCGGAAACGATCGTGTCAGGCATGGCGGGACGCTATGCGACCGCGCTGTTCGAGCTGGCGGACGAAGCCGGTGCCATCGATTCCGTCCAGGCGGATCTTGATCGCCTGTCCGGCCTTCTGGCCGAGAGCGCGGATCTGGCGCGGCTGGTCAAGAGCCCGGTCTTCACCGCCGAGCAGCAGCTCGGCGCGATGGCGGCCATTCTCGATCAAGCAGGCATTTCCGGCCTTGCGGGCAAATTCGTGAAGCTGGTGGCGCAGAACCGCCGCCTGTTCGCACTGCCGCGCATGATTGCCGAATACGCCGTCCTGGTGGCCCGGAAGAAGGGCGAGACCTCGGCGAGCGTGACCGTTGCCACCCCCCTGAGCGATGAGCATCTGGCCACGCTCAAGGCGGCCCTGGCTGAAAAGACCGGCAAGGACGTGAAGCTCGACGTCACCGTCGATCCGTCCATCCTCGGTGGTCTCATCGTGAAGCTCGGCTCGCGCATGGTCGATGCTTCCCTGAAGACCAAACTCAATTCTATCCGGCATGCGATGAAAGAGGTCCGCTGA
SEQ ID NO:39:
ATP合酶亚基δatpH的氨基酸序列
MAETIVSGMAGRYATALFELADEAGAIDSVQADLDRLSGLLAESADLARLVKSPVFTAEQQLGAMAAILDQAGISGLAGKFVKLVAQNRRLFALPRMIAEYAVLVARKKGETSASVTVATPLSDEHLATLKAALAEKTGKDVKLDVTVDPSILGGLIVKLGSRMVDASLKTKLNSIRHAMKEVR
SEQ ID NO:40:
ATP合酶亚基b atpF_2的核苷酸序列
ATGACCGAAATGGAACTGGCTGAGCTCTGGGTCGCCATCGCCTTCCTGGTTTTCGTAGGCCTCCTGATCTATGCGGGCGCCCACCGCGCCATCGTCTCCGCCCTGGATTCCCGCGGCTCGCGCATCGCCTCGGAACTGGAGGAGGCCCGTCGGCTCAAGGAAGAGGCCCAGAAGCTGGTGGCCGAATTCAAGCGCAAGCAGCGCGAGGCCGAGGCCGAGGCCGAATCCATCGTCACCGGCGCCAAGGCCGAGGCCGAGCGCCTCGCCGCCGAGGCCAAGGCGAAGATCGAGGATTTCGTCACCCGCCGCACCAAGATGGCCGAGGACAAGATCGCCCAGGCCGAGCATCAGGCTCTGGCGGACGTGAAGTCCATCGCCGCCGAGGCGGCGGCCAAGGCGGCCGAGGTGATCCTCGGCGCCCAGGCCACCGGCGCGGTGGCGGAGCGTCTGCTGTCGGGCGCCATCTCCGAGGTCAAGACCAAGCTCAACTGA
SEQ ID NO:41:
ATP合酶亚基b atpF_2的氨基酸序列
MTEMELAELWVAIAFLVFVGLLIYAGAHRAIVSALDSRGSRIASELEEARRLKEEAQKLVAEFKRKQREAEAEAESIVTGAKAEAERLAAEAKAKIEDFVTRRTKMAEDKIAQAEHQALADVKSIAAEAAAKAAEVILGAQATGAVAERLLSGAISEVKTKLN
SEQ ID NO:42:
ATP合酶亚基b'atpG_3的核苷酸序列
ATGATGATTGCATGGAAGCGGACCTTCGCAGTCGTGACCTTCGGGGCCGCCCTGATGGCCATGCCCGTCGCGGGCGTGGTCGCAGCTGAGACTTCTCCCGCTCCGGCGGCAGTGGCGCAGGCCGATCATGCGGTGCCCACCGAGGCGGCCGGCCAGGGCACCGCCGATGCGGCCCATGCCGCCGCGCCGGGCGAGGCCGCCCATGGTGGCGCGGCCAAGCACGAAACCCATTTCCCGCCCTTCGACGGCACCACCTTCGCCTCCCAGTTGCTGTGGCTCGCCGTCACCTTCGGCCTGCTTTACTACCTCATGAGCAAGGTCACGCTGCCGCGCATCGGCCGCATCCTGGAAGAGCGCCACGACCGCATCGCCGATGATCTGGAGGAAGCCTCCAAGCATCGCGCCGAGAGCGAGGCCGCCCAGCGGGCCTATGAGAAGGCGCTGAGCGAGGCCCGCGCGAAGGCCCATTCCATCGCCGCGGAAACCCGCGACCGCCTTGCCGCCCACGCCGACACCAACCGCAAGGCGCTGGAGAGCGAGCTCACCGCCAAGCTGCAGGCGGCCGAGGAGCGCATCGCCACCACCAAGAGCGAAGCCCTCACCCATGTGCGCGGCATCGCGGTGGACGCCACCCAATCCATCGTCTCCACCCTCATCGGTGTCGCGCCCGCGGCGGCCGACGTGGAAAAAGCGGTGGACGGCGCCCTGTCCCAGCACGGCCAGGCCTGA
SEQ ID NO:43:
ATP合酶亚基b'atpG_3的氨基酸序列
MMIAWKRTFAVVTFGAALMAMPVAGVVAAETSPAPAAVAQADHAVPTEAAGQGTADAAHAAAPGEAAHGGAAKHETHFPPFDGTTFASQLLWLAVTFGLLYYLMSKVTLPRIGRILEERHDRIADDLEEASKHRAESEAAQRAYEKALSEARAKAHSIAAETRDRLAAHADTNRKALESELTAKLQAAEERIATTKSEALTHVRGIAVDATQSIVSTLIGVAPAAADVEKAVDGALSQHGQA
SEQ ID NO:44:
ATP合酶亚基c atpE_2的核苷酸序列
ATGGAAGCGGAAGCTGGAAAGTTCATCGGTGCCGGCCTCGCCTGCCTCGGCATGGGTCTCGCTGGCGTCGGCGTCGGTAACATCTTCGGTAACTTCCTCTCCGGCGCCCTGCGCAACCCGTCCGCTGCCGACGGCCAGTTCGCCCGCGCCTTCATCGGCGCCGCCCTCGCGGAAGGTCTCGGCATCTTCTCGCTGGTCGTTGCGCTCGTCCTGCTGTTCGTGGCCTGA
SEQ ID NO:45:
ATP合酶亚基c atpE_2的氨基酸序列
MEAEAGKFIGAGLACLGMGLAGVGVGNIFGNFLSGALRNPSAADGQFARAFIGAALAEGLGIFSLVVALVLLFVA
SEQ ID NO:46:
ATP合酶亚基a atpB_2的核苷酸序列
ATGACCGTCGATCCGATCCACCAGTTCGAGATCAAGCGCTACGTGGATCTGCTGAACGTCGGCGGTGTCCAGTTCTCCTTCACCAACGCAACGGTGTTCATGATTGGCATCGTCCTGGTGATTTTCTTCTTCCTGACTTTCGCGACACGCGGTCGCACCCTTGTGCCGGGCCGGATGCAGTCGGCGGCGGAGCTGAGCTACGAGTTCATCGCCAAGATGGTGCGCGACGCGGCCGGCAGCGAGGGAATGGTGTTCTTTCCCTTCGTCTTCTCGCTCTTCATGTTCGTGCTGGTGGCGAACGTATTGGGGCTCATCCCCTACACCTTCACGGTGACCGCCCACCTCATCGTCACCGCCGCCCTGGCGGCGACGGTGATCCTCACCGTCATCATCTACGGCTTCGTGCGGCACGGCACCCACTTCCTGCACCTGTTCGTGCCGTCGGGCGTGCCGGGCTTCCTCCTGCCCTTCCTCGTGGTGATCGAGGTGGTGTCGTTCCTGTCGCGGCCCATCAGCCTCTCGCTGCGTCTGTTCGCCAACATGCTGGCGGGCCACATCGCCCTCAAGGTGTTCGCCTTCTTCGTCGTGGGACTGGCCTCGGCCGGCGCGATCGGCTGGTTCGGCGCCACCCTGCCCTTCTTCATGATCGTGGCGCTCACCGCGCTGGAGCTGCTGGTGGCGGTGCTGCAGGCCTACGTGTTCGCGGTGCTGACCTCGATCTACCTCAACGACGCCATCCATCCCGGCCACTGA
SEQ ID NO:47:
ATP合酶亚基a atpB_2的氨基酸序列
MTVDPIHQFEIKRYVDLLNVGGVQFSFTNATVFMIGIVLVIFFFLTFATRGRTLVPGRMQSAAELSYEFIAKMVRDAAGSEGMVFFPFVFSLFMFVLVANVLGLIPYTFTVTAHLIVTAALAATVILTVIIYGFVRHGTHFLHLFVPSGVPGFLLPFLVVIEVVSFLSRPISLSLRLFANMLAGHIALKVFAFFVVGLASAGAIGWFGATLPFFMIVALTALELLVAVLQAYVFAVLTSIYLNDAIHPGH
SEQ ID NO:48:
ATP合酶蛋白I atpI的核苷酸序列
ATGTCCGAGCCGAATGATCCATCCCGCAGGGACGGTGCGAAGGCGAAAGACGAGACGCAGGACTCCCGGCCCGGTGAGGCGGATCTTGCTCGGCGCCTCGATGCGCTCGGCACCTCCATCGGTCAGGTCAAGTCCAGAAGCGGGGAGCCCGCGGCGACGCCGCGCAAGGACACCTCCTCGGCCTCCGGCGCGGCCCTGGCGTTTCGGCTGGGCGCCGAGTTTGTTTCAGGCGTGCTGGTGGGCTCGCTCATCGGCTACGGGTTGGATTATGCGTTTGCGATTTCGCCCTGGGGGCTGATCGCCTTCACGCTGATCGGCTTTGCCGCCGGCGTCCTGAACATGCTGCGCGTGGCGAACAGCGATGCCAAGCGCCACAGCGCGGACAGGTGA
SEQ ID NO:49:
ATP合酶蛋白I atpI的氨基酸序列
MSEPNDPSRRDGAKAKDETQDSRPGEADLARRLDALGTSIGQVKSRSGEPAATPRKDTSSASGAALAFRLGAEFVSGVLVGSLIGYGLDYAFAISPWGLIAFTLIGFAAGVLNMLRVANSDAKRHSADR
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码固氮酶钼铁蛋白α链nifD_1的基因,其具有SEQ ID NO:51中所示的序列,或者与SEQ ID NO:51中所示的序列具有多于60%的一致性,例如多于70%的一致性,例如多于92%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码固氮酶钼铁蛋白α链nifD_2的基因,其具有SEQ ID NO:53中所示的序列,或者与SEQ ID NO:53中所示的序列具有多于60%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码固氮酶钼铁蛋白β链nifK_1的基因,其具有SEQ ID NO:55中所示的序列,或者与SEQ ID NO:55中所示的序列具有多于87%的一致性,例如多于90%的一致性,例如多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码固氮酶钼铁蛋白β链nifK_2的基因,其具有SEQ ID NO:57中所示的序列,或者与SEQ ID NO:57中所示的序列具有多于95%的一致性,例如多于96%的一致性,例如多于97%的一致性,例如多于98%,例如多于99%的序列一致性的序列。
在另一个实施方式中,在本发明的方法中使用的细菌菌株包含编码固氮酶铁蛋白nifH的基因,其具有SEQ ID NO:59中所示的序列,或者与SEQ ID NO:59中所示的序列具有多于98.5%的序列一致性的序列。
SEQ ID NO:50:
固氮酶钼铁蛋白α链nifD_1的核苷酸序列
ATGAGTTCGCTCTCCGCCACTATTCAACAGGTCTTCAACGAGCCGGGCTGCGCGAAGAACCAGAATAAGTCCGAGGCGGAGAAGAAGAAGGGCTGCACCAAGCAGCTGCAACCCGGCGGAGCGGCCGGCGGCTGCGCGTTCGACGGCGCGAAGATCGCGCTCCAGCCCTTGACCGACGTCGCCCACCTGGTGCACGGCCCCATCGCCTGCGAAGGCAATTCCTGGGACAATCGTGGCGCCAAGTCCTCCGGCTCGAACATCTGGCGCACCGGCTTCACCACGGACATCAACGAAACCGACGTGGTGTTCGGCGGCGAGAAGCGTCTGTTCAAGTCCATCAAGGAAATCATCGAGAAGTACGACCCGCCGGCCGTCTTCGTCTATCAGACCTGCGTCCCCGCCATGATCGGCGACGACATCGACGCGGTGTGCAAGGCGGCCAGGGAGAAGTTCGGAAAGCCGGTGATCCCGATCAATTCCCCCGGCTTCGTGGGGCCGAAGAATCTCGGCAACAAGCTCGCCGGCGAGGCGCTCCTCGACCATGTGATCGGCACCGAGGAGCCCGATTACACGACGGCCTACGACATCAACATCATCGGCGAATACAATCTCTCCGGCGAGTTGTGGCAGGTGAAGCCGCTGCTGGACGAGCTGGGCATCCGCATCCTCGCCTGCATCTCCGGCGACGGGAAGTACAAGGATGTGGCGTCCTCCCACCGCGCCAAGGCGGCGATGATGGTGTGCTCCAAGGCCATGATCAACGTGGCCCGCAAGATGGAGGAGCGCTACGACATCCCCTTCTTCGAAGGCTCCTTCTACGGCATCGAGGATAGCTCCGATTCCCTGCGCGAGATTGCGCGCATGCTCATCGAGAAGGGCGCCGATCCGGAGCTGATGGACCGCACCGAGGCGCTGATTGAGCGGGAAGAGAAGAAGGCGTGGGACGCCATCGCCGCCTACAAGCCCCGCTTCAAGGACAAGAAGGTGCTGCTCATCACCGGCGGCGTGAAATCCTGGTCGGTGGTGGCAGCGCTCCAGGAAGCCGGCCTCGAACTGGTGGGCACCTCGGTGAAGAAGTCCACCAAGGAGGACAAGGAGCGCATCAAGGAACTGATGGGCCAGGACGCCCACATGATCGACGACATGACGCCCCGCGAAATGTACAAGATGCTGAAGGACGCCAAGGCGGACATCATGCTCTCGGGCGGGCGCTCGCAATTCATCGCGCTCAAGGCCGCCATGCCCTGGCTCGACATCAACCAGGAGCGCCACCACGCCTATATGGGCTATGTGGGCATGGTGAAGCTGGTCGAGGAGATCGACAAGGCGCTCTACAATCCCGTGTGGGAACAGGTGCGCAAGCCCGCCCCGTGGGAAAATCCGGAAGACACCTGGCAGGCCCGTGCGCTCGCCGAAATGGAGGCGGAGGCCGCCGCGCTCGCCGCCGATCCGGTGCGCGCGGAAGAGGTGCGCCGGTCCAAGAAGATCTGCAATTGCAAGAGCGTCGACCTCGGAACCATTGAGGACGCCATCAAGGCTCACGCGCTGACCACCGTGGAGGGTGTGCGAGAGCACACCAATGCCTCGGGAGGCTGCGGAGCCTGCAGCGGGCGGATCGAGGAGATCTTCGAGGCCGTGGGCGTTGTCGCCGCCCCGCCTCCCGCGGAGGCCGCCCCGTCTCCGCAGGAGATCGCGCCCGATCCGCTCGCTGCGGAGGAAAAGCGCCGCGCCAAGAAGGCCTGCGGCTGCAAGGAGGTAGCGGTCGGCACCATTGAGGATGCCATCCGCGCCAAGGGTCTGCGAAACATCGCGGAGGTGCGTGCGGCCACCGATGCCAACACCGGCTGCGGCAATTGCCAGGAGCGGGTGGAGGGCATCCTCGACCGGGTTCTCGCCGAGGCGGCCTCAGAACTCCAGGCGGCGGAATAG
SEQ ID NO:51:
固氮酶钼铁蛋白α链nifD_1的氨基酸序列
MSSLSATIQQVFNEPGCAKNQNKSEAEKKKGCTKQLQPGGAAGGCAFDGAKIALQPLTDVAHLVHGPIACEGNSWDNRGAKSSGSNIWRTGFTTDINETDVVFGGEKRLFKSIKEIIEKYDPPAVFVYQTCVPAMIGDDIDAVCKAAREKFGKPVIPINSPGFVGPKNLGNKLAGEALLDHVIGTEEPDYTTAYDINIIGEYNLSGELWQVKPLLDELGIRILACISGDGKYKDVASSHRAKAAMMVCSKAMINVARKMEERYDIPFFEGSFYGIEDSSDSLREIARMLIEKGADPELMDRTEALIEREEKKAWDAIAAYKPRFKDKKVLLITGGVKSWSVVAALQEAGLELVGTSVKKSTKEDKERIKELMGQDAHMIDDMTPREMYKMLKDAKADIMLSGGRSQFIALKAAMPWLDINQERHHAYMGYVGMVKLVEEIDKALYNPVWEQVRKPAPWENPEDTWQARALAEMEAEAAALAADPVRAEEVRRSKKICNCKSVDLGTIEDAIKAHALTTVEGVREHTNASGGCGACSGRIEEIFEAVGVVAAPPPAEAAPSPQEIAPDPLAAEEKRRAKKACGCKEVAVGTIEDAIRAKGLRNIAEVRAATDANTGCGNCQERVEGILDRVLAEAASELQAAE
SEQ ID NO:52:
固氮酶钼铁蛋白α链nifD_2的核苷酸序列
ATGAGTGTCGCACAGTCCCAGAGCGTCGCCGAGATCAAGGCGCGCAACAAGGAACTCATCGAAGAGGTCCTCAAGGTCTATCCCGAGAAGACCGCCAAGCGCCGCGCCAAGCACCTGAACGTCCACGAAGCCGGCAAGTCCGACTGCGGCGTGAAGTCCAACATCAAGTCCATCCCGGGCGTGATGACCATCCGCGGTTGCGCTTATGCCGGCTCCAAGGGTGTGGTGTGGGGTCCCATCAAGGACATGATCCACATCTCCCACGGCCCGGTGGGCTGCGGCCAGTATAGCTGGGCCGCCCGCCGCAACTACTATATCGGCACGACCGGCATCGACACCTTCGTGACGATGCAGTTCACCTCCGACTTCCAGGAGAAGGACATCGTCTTCGGCGGCGACAAGAAGCTCGCCAAGATCATGGACGAGATCCAGGAGCTGTTCCCGCTGAACAACGGCATCACCGTTCAGTCCGAGTGCCCCATCGGCCTCATCGGCGACGACATCGAGGCCGTCTCCAAGCAGAAGTCCAAGGAGTATGAGGGCAAGACCATCGTGCCGGTGCGCTGCGAGGGCTTCCGCGGCGTGTCCCAGTCCCTGGGCCACCACATCGCCAACGACGCCATCCGCGATTGGGTGTTCGACAAGATCGCGCCCGACGCCGAGCCGCGCTTTGAGCCGACCCCGTACGACGTCGCCATCATCGGCGACTACAATATCGGTGGTGACGCCTGGTCGTCCCGTATCCTCCTGGAGGAGATGGGCCTGCGCGTGATCGCCCAGTGGTCCGGCGACGGTTCGCTCGCTGAGCTGGAGGCCACCCCGAAGGCCAAGCTCAACGTGCTGCACTGCTACCGCTCCATGAACTACATCTCGCGCCACATGGAAGAGAAGTACGGTATCCCGTGGTGCGAGTACAACTTCTTCGGTCCTTCCAAGATCGCCGAGTCCCTGCGCAAGATCGCCAGCTACTTCGACGACAAGATCAAGGAAGGCGCGGAGCGCGTCATCGCCAAGTATCAGCCGCTCATGGATGCGGTGATCGCGAAGTATCGTCCCCGCCTCGAGGGCAAGACCGTGATGCTGTACGTGGGCGGCCTGCGTCCCCGTCACGTCATCGGCGCCTACGAGGACCTGGGCATGGAAGTGGTCGGCACGGGCTACGAGTTCGCCCATAACGACGACTACCAGCGCACCGCCCAGCACTACGTCAAGGATGGCACCATCATCTATGACGACGTGACCGGCTACGAGTTCGAGAAGTTCGTCGAGAAGATCCAGCCGGACCTGGTCGGTTCGGGCATCAAGGAAAAGTACGTCTTCCAGAAGATGGGCGTGCCGTTCCGCCAGATGCACTCCTGGGACTACTCGGGCCCGTACCACGGCTATGACGGCTTCGCGATCTTCGCGCGCGACATGGACATGGCCATCAACAGCCCCGTGTGGAAGATGACCCAGGCTCCGTGGAAGAGCGTCCCCAAGCCGACGATGCTCGCGGCTGAATGA
SEQ ID NO:53:
固氮酶钼铁蛋白α链nifD_2的氨基酸序列
MSVAQSQSVAEIKARNKELIEEVLKVYPEKTAKRRAKHLNVHEAGKSDCGVKSNIKSIPGVMTIRGCAYAGSKGVVWGPIKDMIHISHGPVGCGQYSWAARRNYYIGTTGIDTFVTMQFTSDFQEKDIVFGGDKKLAKIMDEIQELFPLNNGITVQSECPIGLIGDDIEAVSKQKSKEYEGKTIVPVRCEGFRGVSQSLGHHIANDAIRDWVFDKIAPDAEPRFEPTPYDVAIIGDYNIGGDAWSSRILLEEMGLRVIAQWSGDGSLAELEATPKAKLNVLHCYRSMNYISRHMEEKYGIPWCEYNFFGPSKIAESLRKIASYFDDKIKEGAERVIAKYQPLMDAVIAKYRPRLEGKTVMLYVGGLRPRHVIGAYEDLGMEVVGTGYEFAHNDDYQRTAQHYVKDGTIIYDDVTGYEFEKFVEKIQPDLVGSGIKEKYVFQKMGVPFRQMHSWDYSGPYHGYDGFAIFARDMDMAINSPVWKMTQAPWKSVPKPTMLAAE
SEQ ID NO:54:
固氮酶钼铁蛋白β链nifK_1的核苷酸序列
ATGGCCACCGTTTCCGTCTCCAAGAAGGCCTGCGCGGTCAACCCCCTCAAGATGAGCCAGCCGGTGGGCGGCGCGCTCGCCTTCATGGGCGTGCGCAAGGCCATGCCGCTGCTGCACGGCTCGCAGGGCTGCACCTCCTTCGGCCTGGTGCTGTTCGTGCGCCACTTCAAGGAAGCCATCCCCATGCAGACCACCGCCATGAGCGAGGTGGCGACGGTTCTGGGCGGCCTTGAGAATGTGGAGCAGGCCATTCTCAACATCTACAATCGCACCAAGCCGGAGATCATCGGCATCTGCTCCACCGGCGTCACCGAGACCAAGGGCGATGATGTCGACGGCTACATCAAGCTGATCCGGGACAAGTATCCCCAGCTGGCCGACTTCCCGCTGGTCTATGTCTCCACCCCCGATTTCAAGGACGCCTTCCAGGACGGTTGGGAGAAGACCGTGGCGAAGATGGTGGAGGCGCTGGTGAAGCCCGCCGCCGACAAGCAGAAGGACAAGACCCGCGTCAACGTCCTGCCCGGCTGCCACCTCACGCCCGGCGATCTGGATGAGATGCGGACCATCTTCGAGGATTTCGGGCTCACACCCTATTTCCTGCCGGATCTGGCCGGCTCGCTGGATGGGCATATCCCCGAGGACTTCTCGCCCACCACCATCGGCGGCATCGGCATCGATGAGATCGCCACCATGGGCGAGGCGGCCCACACCATCTGCATCGGCGCGCAGATGCGCCGGGCGGGCGAGGCCATGGAGAAGAAGACCGGCATTCCCTTCAAGCTGTTCGAGCGCCTGTGCGGCCTGGAGGCGAACGACGCCTTCATCATGCACCTGTCGCAGATCTCCGGCCGGCCGGTGCCGGTGAAGTATCGCCGGCAGCGGGGCCAGCTGGTGGATGCCATGCTGGACGGCCACTTCCATCTGGGCGGTCGCAAGGTGGCCATGGGGGCGGAGCCGGACCTGCTCTACGACGTGGGCTCCTTCCTGCACGAGATGGGCGCCCACATCCTTTCCGCGGTCACCACCACCCAGTCGCCGGTGCTGGCGCGCCTGCCTGCCGAGGAGGTGCTTATCGGCGACCTGGAGGATCTGGAGACCCAGGCGAAGGCGCGCGGATGCGATCTCCTGCTCACCCATTCCCATGGGCGCCAGGCGGCGGAGCGCCTCCACATCCCCTTCTACCGGATCGGCATTCCCATGTTTGACCGGCTGGGGGCGGGGCATCTGTTGTCGGTGGGCTATCGCGGCACCCGCGACCTCATCTTCCATCTCGCCAACCTTGTGATCGCCGACCACGAGGAAAATCACGAGCCGACGCCCGACACCTGGGCCACCGGCCATGGCGAGCATGCCGCCGCCCCCACTTCCCATTGA
SEQ ID NO:55:
固氮酶钼铁蛋白β链nifK_1的氨基酸序列
MATVSVSKKACAVNPLKMSQPVGGALAFMGVRKAMPLLHGSQGCTSFGLVLFVRHFKEAIPMQTTAMSEVATVLGGLENVEQAILNIYNRTKPEIIGICSTGVTETKGDDVDGYIKLIRDKYPQLADFPLVYVSTPDFKDAFQDGWEKTVAKMVEALVKPAADKQKDKTRVNVLPGCHLTPGDLDEMRTIFEDFGLTPYFLPDLAGSLDGHIPEDFSPTTIGGIGIDEIATMGEAAHTICIGAQMRRAGEAMEKKTGIPFKLFERLCGLEANDAFIMHLSQISGRPVPVKYRRQRGQLVDAMLDGHFHLGGRKVAMGAEPDLLYDVGSFLHEMGAHILSAVTTTQSPVLARLPAEEVLIGDLEDLETQAKARGCDLLLTHSHGRQAAERLHIPFYRIGIPMFDRLGAGHLLSVGYRGTRDLIFHLANLVIADHEENHEPTPDTWATGHGEHAAAPTSH
SEQ ID NO:56:
固氮酶钼铁蛋白β链nifK_2的核苷酸序列
ATGCCACAAAATGCTGACAATGTGCTCGATCACTTCGAGCTCTTCCGTGGTCCCGAATACCAGCAGATGCTGGCCAATAAGAAAAAGATGTTCGAGAACCCCCGCGATCCGGCCGAAGTCGAGCGCGTGCGGGAATGGGCGAAGACTCCTGAATACAAGGAGCTGAACTTCGCCCGCGAGGCGCTCACCGTGAATCCGGCCAAGGCTTGTCAGCCGCTGGGCGCGGTGTTCGTCGCCGTCGGCTTCGAGAGCACGATCCCCTTCGTGCACGGCTCGCAGGGTTGCGTCGCGTATTACCGCTCGCACCTCTCCCGCCACTTCAAGGAGCCGTCCTCCTGCGTCTCCTCGTCCATGACCGAGGATGCGGCGGTGTTCGGCGGCCTCAACAACATGATTGACGGCCTCGCCAACACCTACAACATGTACAAGCCGAAGATGATCGCCGTCTCCACCACCTGCATGGCGGAAGTCATCGGCGACGATCTGAACGCCTTCATCAAGACCGCGAAGGAAAAGGGCTCGGTTCCGGCCGAATACGACGTGCCCTTCGCCCACACCCCGGCGTTCGTCGGCAGCCATGTCACCGGCTACGACAATGCGCTCAAGGGCATCCTCGAGCACTTCTGGGACGGCAAGGCCGGCACCGCGCCGAAGCTGGAGCGCGTTCCCAACGAGAAGATCAACTTCATCGGCGGCTTCGACGGCTACACCGTCGGCAACACTCGCGAAGTGAAGCGCATCTTCGAGGCGTTCGGCGCCGATTACACCATCCTCGCCGACAATTCCGAAGTGTTCGACACCCCGACCGACGGCGAGTTCCGCATGTATGACGGCGGCACGACCCTGGAGGACGCGGCGAACGCGGTGCACGCCAAGGCCACCATCTCCATGCAGGAATACTGCACGGAGAAGACCCTGCCCATGATCGCCGGTCATGGCCAGGACGTGGTCGCCCTCAACCACCCCGTGGGCGTGGGCGGCACCGACAAGTTCCTCATGGAGATCGCCCGCCTCACCGGCAAGGAGATCCCCGAGGAGCTGACCCGCGAGCGCGGCCGTCTCGTGGACGCTATCGCGGACTCTTCCGCGCACATCCACGGCAAGAAGTTCGCCATCTACGGCGATCCGGATCTGTGCCTGGGCCTCGCCGCGTTCCTGCTGGAGCTGGGCGCCGAGCCGACCCATGTGCTGGCCACCAACGGCACCAAGAAGTGGGCCGAGAAGGTTCAGGAACTGTTCGACTCTTCGCCGTTCGGCGCCAACTGCAAGGTCTATCCCGGCAAGGACCTGTGGCACATGCGCTCGCTCCTGTTCGTGGAGCCGGTGGATTTCATCATCGGCAACACCTACGGCAAGTATCTCGAGCGCGACACGGGCACCCCGCTGATCCGTATCGGCTTCCCGGTGTTCGACCGTCACCACCACCACCGCCGTCCGGTGTGGGGCTATCAGGGCGGCATGAACGTCCTGATCACGATCCTCGACAAGATCTTTGACGAGATCGACCGCAACACCAACGTGCCGGCCAAGACCGACTACTCGTTCGACATCATTCGTTGA
SEQ ID NO:57:
固氮酶钼铁蛋白β链nifK_2的氨基酸序列
MPQNADNVLDHFELFRGPEYQQMLANKKKMFENPRDPAEVERVREWAKTPEYKELNFAREALTVNPAKACQPLGAVFVAVGFESTIPFVHGSQGCVAYYRSHLSRHFKEPSSCVSSSMTEDAAVFGGLNNMIDGLANTYNMYKPKMIAVSTTCMAEVIGDDLNAFIKTAKEKGSVPAEYDVPFAHTPAFVGSHVTGYDNALKGILEHFWDGKAGTAPKLERVPNEKINFIGGFDGYTVGNTREVKRIFEAFGADYTILADNSEVFDTPTDGEFRMYDGGTTLEDAANAVHAKATISMQEYCTEKTLPMIAGHGQDVVALNHPVGVGGTDKFLMEIARLTGKEIPEELTRERGRLVDAIADSSAHIHGKKFAIYGDPDLCLGLAAFLLELGAEPTHVLATNGTKKWAEKVQELFDSSPFGANCKVYPGKDLWHMRSLLFVEPVDFIIGNTYGKYLERDTGTPLIRIGFPVFDRHHHHRRPVWGYQGGMNVLITILDKIFDEIDRNTNVPAKTDYSFDIIR
SEQ ID NO:58:
固氮酶铁蛋白nifH的核苷酸序列
GTGGAGTCCGGTGGTCCTGAGCCGGGCGTGGGCTGCGCCGGCCGCGGCGTGATCACCTCCATCAACTTCCTGGAGGAGAACGGCGCCTACGAGGACATCGACTATGTGTCCTACGACGTGCTGGGCGACGTGGTGTGCGGCGGCTTCGCCATGCCCATCCGCGAGAACAAGGCGCAGGAAATCTACATCGTGATGTCCGGCGAGATGATGGCCATGTATGCGGCCAACAACATCTCCAAGGGCATCCTGAAGTATGCCAATTCCGGCGGCGTGCGCCTGGGCGGGCTGGTCTGCAACGAGCGCCAGACCGACAAGGAGCTGGAGCTGGCGGAGGCTCTGGCGAAGAAGCTCGGCACCGAGCTGATCTACTTCGTGCCGCGCGACAACATCGTGCAGCATGCCGAGCTGCGCCGCATGACAGTGATCGAGTATGCGCCCGATTCCGCCCAGGCCCAGCACTACCGGAACCTGGCCGAGAAGGTGCACGCCAACAAGGGCAACGGCATCATCCCGACCCCGATCACCATGGACGAGCTGGAAGACATGCTCATGGAGCACGGCATCATGAAGGCCGTGGACGAGAGCCAGATCGGCAAGACCGCCGCCGAGCTCGCCGTCTGA
SEQ ID NO:59:
固氮酶铁蛋白nifH的氨基酸序列
MESGGPEPGVGCAGRGVITSINFLEENGAYEDIDYVSYDVLGDVVCGGFAMPIRENKAQEIYIVMSGEMMAMYAANNISKGILKYANSGGVRLGGLVCNERQTDKELELAEALAKKLGTELIYFVPRDNIVQHAELRRMTVIEYAPDSAQAQHYRNLAEKVHANKGNGIIPTPITMDELEDMLMEHGIMKAVDESQIGKTAAELAV
下游加工
在一个实施方式中,本发明的方法包括收获在培养期间产生的生物质的进一步步骤。例如,生物质可以通过沉淀(基于重力的沉降)、过滤、离心或絮凝进行收获。絮凝可能需要絮凝剂的添加。离心可以例如使用连续流动离心机来进行。
在一个实施方式中,收获的生物质随后进行干燥。干燥可以例如使用众所周知的方法来执行,所述方法包括离心、滚筒干燥、蒸发、冷冻干燥、加热、喷雾干燥、真空干燥和/或真空过滤。干燥的生物质随后可以用于产物例如食物或饲料产物或者饲料或食物成分中。
在另一个实施方式中,使收获的生物质的细胞裂解。在一些实施方式中,裂解物可以分离成不溶性级分和可溶性级分,其中任一或两者随后可以进行浓缩或干燥,并且随后用于产物例如食物或饲料产物中。
在一个实施方式中,收获生物质并从所述生物质中分离蛋白质,得到蛋白质级分和包含非蛋白质组分的级分。因此,在一个实施方式中,该方法用于生产蛋白质,并且包括培养菌株VTT-E-193585或其衍生物的步骤,随后为收获生物质的步骤和从所述生物质中分离蛋白质的进一步步骤。在另一个实施方式中,该方法用于生产蛋白质,并且包括在使用无机碳源和作为能源的氢的连续培养中培养黄色杆菌属的细菌菌株,其中所述无机碳源包括二氧化碳,随后为收获生物质的步骤和从所述生物质中分离蛋白质的进一步步骤。取决于蛋白质分离的方法,所得到的级分可能更纯或更不纯。因此,术语“蛋白质级分”意指富含蛋白质的级分。蛋白质级分仍可能包含大量(significant amounts)的其它组分,而且大量的蛋白质也可能最终在“包含非蛋白质组分的级分”中。
蛋白质的分离可以使用任何合适的方法执行。例如,在一个实施方式中,蛋白质通过以下进行分离:机械破碎细胞,并且经由一个或多个过滤步骤,例如经由孔径越来越小的多重过滤器的相继过滤,从细胞碎片中分离蛋白质。机械破碎可以使用任何合适的方法来进行,所述方法例如球磨、超声处理、匀浆化、高压匀浆化、机械剪切等。所得到的过滤的蛋白质级分将富含蛋白质,但也仍然含有其它较小的组分。蛋白质可以任选地使用任何合适的方法从该级分中进行进一步纯化。
在另一个实施方式中,通过执行乙醇提取,随后为一个或更多个过滤步骤来分离蛋白质级分。此类方法例如由从大豆蛋白的制备已知(参见例如,通过Berk FAOAgricultural Services Bulletin No.97(1992)的“Technology of production ofedible flours and protein products from soybeans”中的第5章“Soybean ProteinConcentrates”。所得到的蛋白质级分将富含蛋白质,但也仍然含有其它组分。蛋白质可以任选地使用任何合适的方法从该级分中进行进一步纯化。
在一个实施方式中,本发明的方法包括使得自本发明的方法的蛋白质级分水解,以获得氨基酸和小肽的进一步步骤。
在本发明的方法的一个实施方式中,该方法包括从所述生物质、所述蛋白质级分或所述包含非蛋白质组分的级分生产食物或饲料产物的进一步步骤。所述进一步步骤可以简单地包括通过在食物或饲料产物的生产期间将其加入,将所述生物质、蛋白质级分或包含非蛋白质组分的级分掺入食物或饲料产物中。在其它实施方式中,在将其掺入食物或饲料产物内的过程期间,执行生物质或其级分的进一步纯化或修饰。
在一个进一步方面,本发明涉及通过根据本发明的方法获得或可获得的产物,例如生物质、蛋白质或非蛋白质组分。
在一个实施方式中,从本发明的方法获得的产物包含多于40%的蛋白质,例如40%至99%的蛋白质,例如40%至90%的蛋白质,例如40%至60%的蛋白质。在一个特定的实施方式中,该产物包含25%至75%的蛋白质、0%至20%的脂质和5%至40%的碳水化合物。在一个进一步的实施方式中,该产物包含40%至60%的蛋白质、0%至15%的脂质和10%至25%的碳水化合物。在一个更进一步的实施方式中,从本发明的方法获得的产物包含45%至55%的蛋白质、5%至10%的脂质和10%至20%的碳水化合物。
如上所述,在一个进一步方面,本发明涉及通过根据本发明的方法获得或可获得的食物或饲料产物。当在本文中使用时,术语“食物”和“饲料”预期不仅包括常规的食物和饲料产物,例如加工食物,而且还包括相关产物,例如食物和饲料补充剂,例如蛋白质棒、粉末或奶昔,肉类替代物,食物成分,益生菌,益生元,营养制品等等。在某些实施方式中,所述生物质、所述蛋白质级分或所述包含非蛋白质组分的级分用于生产素食或纯素食物产物。
本发明通过下述非限制性实施例进行进一步说明。
实施例
实施例1.能够化能自养生长的细菌菌株的分离
从芬兰Naantali的波罗的海海岸,将含有土壤和海水的50mL样品收集到无菌falcon管中。将部分土壤样品与10mL矿物质培养基在无菌的锥形瓶中混合。培养基由在自来水中制备的以下组成:1g/L NH4OH、0.23g/L KH2PO4、0.29g/L Na2HPO4·2H2O、0.005g/LNaVO3·H2O、0.2g/L FeSO4·7H2O、0.5g/L MgSO4·7H2O、0.01g/L CaSO4、0.00015g/LNa2MoO4·2H2O、0.005g/L MnSO4、0.0005g/L ZnSO4·7H2O、0.0015g/L H3BO3、0.001g/LCoSO4、0.00005g/L CuSO4和0.0001g/L NiSO4。土壤和培养基的悬浮液在密封钢箱中的+30℃温度的振荡培养箱中进行温育,所述密封钢箱用以下的气体混合物进行连续冲洗:150mL/分钟的N2、18mL/分钟的H2、3mL/分钟的O2和6mL/分钟的CO2。通过获取1mL悬浮液,将其在无菌条件下加入锥形瓶中的9mL培养基中,然后放回温育箱内,以七天间隔更新培养。在第四次稀释后,悬浮液中不存在明显的土壤残留。将细胞悬浮液的体积增加到100mL,以便生长生物质用于生物反应器培养。当悬浮液接种到15个容器的200-mL平行生物反应器系统(Medicel Explorer,Medicel Oy,芬兰)中的190mL矿物质培养基时,它的光密度(OD600)是1.53。培养条件是800rpm的搅动,+30℃的温度,并且pH设定为6.8,用1M NaOH控制所述pH。气体通过喷雾器用气体混合物进料,所述气体混合物由14mL/分钟的H2、3mL/分钟的O2和6mL/分钟的CO2组成。反应器的顶部空间用300mL/分钟的空气进行冲洗。连续培养用6mL/小时的矿物质培养基进行进料,并且经由毛细管从反应器中抽取细胞悬浮液,使体积保持恒定在200mL。从反应器中抽取的细胞悬浮液贮存于+4℃下。每天从生物反应器中自动获取样品,并且测量在600nm处的吸光度,以监测生长。在生物反应器培养498小时后,无菌抽取样品,并且将悬浮液稀释且铺平板到含有上述矿物质和2%细菌学琼脂的琼脂矿物质培养基平板上。平板在与上文对于锥形瓶描述的相同的条件下进行温育。然后从琼脂平板中挑选菌落,并且在新的琼脂平板上进行划线培养,以便分离一个菌落中的一种生物。这重复两次。挑选单一菌落,且悬浮到96孔微量滴定板中的200μL培养基内。使悬浮液在+30℃温度下温育,并且在EnzyScreen气密箱中振荡625rpm,所述EnzyScreen气密箱用150mL/分钟的N2、18mL/分钟的H2、3mL/分钟的O2和6mL/分钟的CO2进行持续冲洗。将来自一个孔的悬浮液转移到锥形瓶,并且补充有新鲜培养基。增加体积,直到存在足够的生物质以执行生物反应器培养。该生物以VTT-E-193585保藏于VTT培养物保藏中心。
样品的16S rRNA测序证实了该样品只含有一种生物体。同一样品用于IlluminaNextSeq测序,提供了1x150 bp的宏基因组鸟枪法序列。使用Unicycler(Wick等人,2017PLoS computational biology 13:e1005595),对于由101个重叠群组成的宏基因组序列进行从新组装。总基因组长度为4846739bp,且GC含量为67.9%。基因预测和功能注释使用Prokka(Seemann,2014Bioinformatics 30:2068)来执行。基因组注释产生了4429个基因。Roary泛基因组比对(Page等人,2015Bioinformatics 31:3691)将VTT-E-193585分组在黄色杆菌属物种中。因此,该菌株被鉴定为黄色杆菌属sp.,最接近的基因组是万寿菊黄色杆菌。只考虑直向同源片段(OrthoANI)(Lee等人,2016Int J Syst Evol Microbiol 66:1100),基于比对的平均核苷酸一致性计算给出了与万寿菊黄色杆菌(ATCC 700314;GCF_003667445.1)80.4%的最佳匹配,而提议的物种边界截断为95-96%(参见例如,Chun等人,2018Int J Syst Evol Microbiol,68:461-466)。自养黄色杆菌Py2给出79.6%的匹配,而关于黄色杆菌属sp.91的匹配为79.0%。因此,可以得出结论,以VTT-E-193585保藏的分离的细菌菌株属于门:变形菌门(Proteobacteria);属于纲:α-变形菌纲(AlphaProteobacteria);且属于目:根瘤菌目(Rhizobiales)。最可能的科是黄色杆菌科且最有可能的属是黄色杆菌属。VTT-E-193585细菌菌株不能明确地分配到任何已知的种。
执行了关于推定的抗微生物抗性基因的搜索。使用ABRicate(https://github.com/tseemann/abricate)工具,以使用blastn或blastp针对Arg-Annot、NCBI、ResFinder、the ecOH、Megares和VFDB数据库搜索基因组。在核苷酸和蛋白质水平上,对于一致性和覆盖率两者均设定了50%的阈值。只鉴定了两个推定的抗微生物抗性基因。这两个基因不含与抗生素抗性相联系的氨基酸变化,并且因此并没有预期的抗性表型。
实施例2.分离的细菌菌株的中试培养和分析
以VTT-E-193585保藏的分离的细菌菌株在常规的200升搅拌罐生物反应器(MPF-U,Marubishi Ltd,日本)中进行培养。用以400rpm旋转的Rushton型叶轮执行混合。培养中的温度维持在+30℃下。通过经由软件控制加入8M NaOH或3.6M H3PO4,使pH维持在6.8±0.2下。培养基含有在自来水中制备的1g/L NH4OH、0.23g/L KH2PO4、0.29g/L Na2HPO4·2H2O、0.005g/L NaVO3·H2O、0.2g/L FeSO4·7H2O、0.5g/L MgSO4·7H2O、0.01g/L CaSO4、0.00015g/L Na2MoO4·2H2O、0.005g/L MnSO4、0.0005g/L ZnSO4·7H2O、0.0015g/L H3BO3、0.001g/L CoSO4、0.00005g/L CuSO4和0.0001g/L NiSO4。持续供应含有1.8-10.5L/分钟的氢气、0.6-2.5L/分钟的氧气和1.8-5L/分钟的二氧化碳气体的混合物作为能量和碳的主要来源。通过调整气体混合物组成,将溶解氧水平维持在7.2±0.5%下。用于培养的接种物如实施例1中所述进行制备。通过以下监测生长:手动获取样品,并且通过测量在600nm处的吸光度(Ultrospec 2100pro UV/可见光分光光度计,Biochrom Ltd.,英国),且通过经由在105℃下的烘箱中干燥过夜测量细胞干重(CDW),来分析作为光密度的细胞密度。光密度也通过使用原位吸光度探头(Trucell 2,Finesse Ltd,USA)进行监测。图1中呈现了培养的生长曲线。分批阶段的最大生长速率为0.06h-1。最大细胞密度为在92小时的4.5g_CDW/L。在培养92小时后,以0.01h-1的稀释速率起始如上所述的新鲜培养基的进料。在继续进料期间,细胞密度平均为2.9g_CDW/L。培养液不断地收集到冷却(+10℃)罐,从其中它以300升的分批进料到连续离心分离器(BTPX-205,Alfa-Laval AB,瑞典)。从分离器中收集的含细胞的浆料进料到常压双滚筒干燥器(Buflovak 6x8 ADDD,Hebeler process solutions Llc.,USA),用4巴蒸汽加热,且滚筒以3.5rpm旋转。这得到具有大约96%干物质含量的干燥细胞粉末。干燥细胞粉末的分析结果关于近似组成呈现于表1中,关于氨基酸组成呈现于表2中,关于脂肪酸组成呈现于表3中,并且关于维生素含量呈现于表4中。分析证实了,干燥细胞粉末具有含有所有必需氨基酸的高蛋白质含量。它还含有比饱和脂肪酸更多的不饱和脂肪酸和大量的B族维生素。肽聚糖含量仅为0.002mg/g_CDW,并且脂多糖含量为0.01mg/g_CDW。这些浓度尽可能小是有益的。相比之下,在同一时间分析的商业乳酸菌制剂中,肽聚糖含量为0.244mg/g_DW,并且脂多糖含量为0.015mg/g_DW。使用培养的上清液样品执行细胞毒性和遗传毒性测定。并未观察到针对HepG2或HeLa229人细胞系的细胞毒性。并未观察到针对大肠杆菌WP2 trp-或CM871 uvrA recA lexA菌株的遗传毒性。
表1.以VTT-E-193585保藏的分离细菌菌株的干燥细胞粉末的分析结果。
参数 | 方法 | 单位 | 值 |
水分 | 在103℃下干燥 | g/100g | 3.3 |
蛋白质 | 凯氏定氮(N x 6.25) | g/100g | 72.2 |
脂肪 | Weibull-Stoldt | g/100g | 6.0 |
饱和脂肪酸 | 基于表3计算 | g/100g | 1.8 |
单不饱和脂肪酸 | 基于表3计算 | g/100g | 3.8 |
多不饱和脂肪酸 | 基于表3计算 | g/100g | 0.4 |
ω3脂肪酸 | 基于表3计算 | g/100g | <0.01 |
ω6脂肪酸 | 基于表3计算 | g/100g | 0.4 |
膳食纤维 | 重量测定 | g/100g | 10.5 |
灰分 | 在550℃下灰化 | g/100g | 5.8 |
葡萄糖 | HPLC-ELSD | g/100g | <0.15 |
果糖 | HPLC-ELSD | g/100g | <0.1 |
蔗糖 | HPLC-ELSD | g/100g | <0.1 |
乳糖 | HPLC-ELSD | g/100g | <0.25 |
麦芽糖 | HPLC-ELSD | g/100g | <0.2 |
总糖 | 计算 | g/100g | <0.8 |
碳水化合物 | 计算 | g/100g | 2.2 |
能量 | 计算 | kJ/100g | 1572 |
能量 | 计算 | kcal/100g | 373 |
表2.以VTT-E-193585保藏的分离细菌菌株的干燥细胞粉末的氨基酸组成。
参数 | 方法 | 单位 | 值 |
赖氨酸 | 离子色谱法 | % | 3.95 |
甲硫氨酸 | 离子色谱法 | % | 1.60 |
胱氨酸 | 离子色谱法 | % | 0.39 |
天冬氨酸 | 离子色谱法 | % | 6.82 |
苏氨酸 | 离子色谱法 | % | 3.47 |
丝氨酸 | 离子色谱法 | % | 2.75 |
谷氨酸 | 离子色谱法 | % | 8.84 |
脯氨酸 | 离子色谱法 | % | 3.14 |
甘氨酸 | 离子色谱法 | % | 4.40 |
丙氨酸 | 离子色谱法 | % | 6.94 |
缬氨酸 | 离子色谱法 | % | 4.96 |
异亮氨酸 | 离子色谱法 | % | 3.34 |
亮氨酸 | 离子色谱法 | % | 6.08 |
酪氨酸 | 离子色谱法 | % | 2.99 |
苯丙氨酸 | 离子色谱法 | % | 4.58 |
组氨酸 | 离子色谱法 | % | 1.66 |
精氨酸 | 离子色谱法 | % | 4.96 |
色氨酸 | HPLC | % | 1.34 |
表3.以VTT-E-193585保藏的分离细菌菌株的干燥细胞粉末的脂肪酸组成。
表4.以VTT-E-193585保藏的分离细菌菌株的干燥细胞粉末的维生素含量。
参数 | 方法 | 单位 | 值 |
维生素A(RE) | HPLC | IU/100g | <100 |
维生素E(TE) | HPLC | mg/100g | 0.33 |
维生素D3 | HPLC | IU/100g | <10 |
维生素D2 | HPLC | IU/100g | 21.6 |
维生素C | HPLC | mg/100g | <1 |
盐酸氯化硫胺素 | LC-MS/MS | mg/100g | 0.9 |
维生素B1(硫胺素) | 计算 | mg/100g | 0.708 |
维生素B2(核黄素) | HPLC | mg/100g | 6.27 |
盐酸吡哆醇 | HPLC | mg/100g | 3.39 |
维生素B6(吡哆醇) | 计算 | mg/100g | 2.79 |
维生素B12 | LC-MS/MS | μg/100g | 224 |
氯化胆碱 | LC-MS/MS | mg/100g | 14.3 |
生物素 | LC-MS/MS | μg/100g | 15.6 |
叶酸 | 微生物学 | μg/100g | 1270 |
烟酸(维生素B3) | 微生物学 | mg/100g | 23.2 |
泛酸 | 微生物学 | mg/100g | 6.53 |
实施例3.在不同的氮源上培养分离的细菌菌株。
以VTT-E-193585保藏的分离的细菌菌株在以200mL体积的15个容器的平行生物反应器系统(Medicel Explorer,Medicel Oy,芬兰)中进行培养。用以800rpm旋转的Rushton型叶轮执行混合。培养中的温度维持在+30℃下。通过添加1M NaOH使pH维持在6.8下。培养基含有在自来水中制备的0.23g/L KH2PO4、0.29g/L Na2HPO4·2H2O、0.005g/L NaVO3·H2O、0.2g/L FeSO4·7H2O、0.5g/L MgSO4·7H2O、0.01g/L CaSO4、0.00015g/L Na2MoO4·2H2O、0.005g/L MnSO4、0.0005g/L ZnSO4·7H2O、0.0015g/L H3BO3、0.001g/L CoSO4、0.00005g/LCuSO4和0.0001g/L NiSO4。此外,氮源在培养中是不同的,使得四个培养含有18.7mM NH4OH,四个培养含有9.34mM尿素(OC(NH2)2),四个培养含有18.7mM硝酸钾(KNO3),并且剩下三个培养在培养基中不含氮源。持续供应含有22mL/分钟的氢气、3.2mL/分钟的空气和6.4mL/分钟的二氧化碳气体的混合物作为能量和碳的主要来源。因此,与空气一起,所有的培养也供应有氮气。通过以下监测生长:自动获取样品,并且通过测量在600nm处的吸光度(Ultrospec2100pro UV/可见光分光光度计,Biochrom Ltd.,英国),分析作为光密度的细胞密度。培养的生长曲线呈现于图2中。在氨和尿素上的生长是相当的。在硝酸盐或氮气上的生长明显比在氨或尿素上的生长更慢。在培养结束时,在硝酸盐上的生长比在作为唯一氮源的氮气上的生长更好。然而,在其中氮气是唯一氮源的培养中也存在生长,其证实了以VTT-E-193585保藏的分离的细菌菌株能够固氮。
实施例4.抗生素敏感性的表征
根据CLSI M07-A111标准(Clinical and laboratory standardsinstitute.Methods for dilution antimicrobial susceptibility tests forbacteria that grow aerobically,第11版CLSI standard M07,2018),分析以VTT-E-193585保藏的分离细菌菌株对庆大霉素、卡那霉素、链霉素、四环素、氨苄西林、环丙沙星、粘菌素和磷霉素的抗生素敏感性,其中对于氨苄西林、环丙沙星和粘菌素用手动制备的微量稀释平板,对于庆大霉素、卡那霉素、链霉素和四环素使用微量肉汤稀释法与VetMICLact-1平板(SVA National Veterinary Institute,Uppsala,瑞典),并且对于磷霉素使用阳离子调整的Mueller Hinton肉汤-培养基(LabM,LAB114,分开添加阳离子Mg2+和Ca2+),使用琼脂稀释法在好氧条件下在+35±2℃下共48±1小时。大肠杆菌ATCC25922用作质量控制菌株,并且使它在好氧条件下、在+35±2℃下温育18±2小时。菌株的抗生素敏感性结果呈现于表5中。发现分离的细菌菌株对抗生素是普遍敏感的。对于庆大霉素、卡那霉素、链霉素和四环素,关于VTT-E-193585的最低抑菌浓度(MIC)值小于大肠杆菌ATCC 25922或与其相当,而对于氨苄西林、环丙沙星、粘菌素和磷霉素,MIC值在VTT-E-193585中更高。
表5.关于VTT-E-193585菌株和大肠杆菌ATCC 25922的抗生素的最低抑菌浓度(MIC,μg/ml)值
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序列表
<110> 太阳食物有限公司
<120> 用于单细胞蛋白质或生物质生产的菌株和方法
<130> Solar002
<160> 59
<170> PatentIn version 3.5
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<213> 未知
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gacgatcagt agctggtctg agaggatgat cagccacact gggactgaga cacggcccag 300
actcctacgg gaggcagcag tggggaatat tggacaatgg gcgcaagcct gatccagcca 360
tgccgcgtgt gtgatgaagg ccttagggtt gtaaagcact ttcgccggtg aagataatga 420
cggtaaccgg agaagaagcc ccggctaact tcgtgccagc agccgcggta atacgaaggg 480
ggctagcgtt gctcggaatc actgggcgta aagcgcacgt aggcggatcg ttaagtcagg 540
ggtgaaatcc tggagctcaa ctccagaact gcccttgata ctggcgacct tgagttcgag 600
agaggttggt ggaactgcga gtgtagaggt gaaattcgta gatattcgca agaacaccag 660
tggcgaaggc ggccaactgg ctcgatactg acgctgaggt gcgaaagcgt ggggagcaaa 720
caggattaga taccctggta gtccacgccg taaacgatgg atgctagccg ttgggcagct 780
tgctgttcag tggcgcagct aacgcattaa gcatcccgcc tggggagtac ggtcgcaaga 840
ttaaaactca aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg 900
aagcaacgcg cagaacctta ccagcctttg acatggcagg acgatttcca gagatggatc 960
tcttccagca atggacctgc acacaggtgc tgcatggctg tcgtcagctc gtgtcgtgag 1020
atgttgggtt aagtcccgca acgagcgcaa ccctcgcctc tagttgccag cattcagttg 1080
ggcactctag agggactgcc ggtgataagc cgagaggaag gtggggatga cgtcaagtcc 1140
tcatggccct tacgggctgg gctacacacg tgctacaatg gtggtgacag tgggatgcga 1200
aagggcgacc tctagcaaat ctccaaaagc catctcagtt cggattgtac tctgcaactc 1260
gagtgcatga agttggaatc gctagtaatc gtggatcagc atgccacggt gaatacgttc 1320
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gcggtcgccg gcgaaagctc caccgctacc tggaccgtgg tgtggaccga ccggctcacc 240
gccgccgacg tctaccgcgc caaggcctac aaggtggagc cggtgccggg ccaggaaggc 300
cagtatttct gctacatcgc ctatgatctc gatttgttcg aggaaggctc catcgccaac 360
ctcacggcgt cgatcatcgg caacgtcttc tccttcaagc cgctgaaggc ggcgcggctg 420
gaggacatgc ggcttcccgt cgcctatgtg aagaccttcc gcggcccgcc caccggcatc 480
gtggtcgagc gcgagcgcct ggacaagttc ggccgccccc ttctgggcgc caccaccaag 540
ccgaagcttg gcctctcggg caagaattac ggccgcgtgg tctatgaggc cctcaagggc 600
ggcctcgact tcgtgaagga cgacgagaac atcaactcgc agcccttcat gcactggcgc 660
gatcgcttcc tctattgcat ggaggccgtc aacaaggccc aggccgagac cggcgaggtg 720
aaggggcact atctcaacat caccgccggg accatggagg agatgtaccg ccgcgccgag 780
ttcgccaagg aactgggctc cgtggtggtg atggtggatc tcatcatcgg ctggaccgcc 840
atccagtcca tgtccaactg gtgccgcgag aacgacatga tcctgcacat gcaccgtgcg 900
ggccatggca cctacacgcg ccagaagagc cacggcgtct ccttccgcgt catcgccaag 960
tggctgcggc tcgccggcgt cgaccacctg cacaccggca ccgccgtggg caagctggaa 1020
ggcgacccca tgaccgtgca gggcttctac aatgtctgcc gcgagacgac gacgcagcag 1080
gacctcaccc gcggcctgtt cttcgagcag gactggggcg gcatccgcaa ggtgatgccg 1140
gtggcctccg gcggcatcca tgcgggccag atgcaccagc tcatcgacct gttcggcgag 1200
gacgtggtgc tccagttcgg cggcggcacc atcggccacc cggacggcat ccaggccggc 1260
gccaccgcca accgcgtggc gctggaaacc atgatcctcg cccgcaacga gggccgcgac 1320
atcaggaacg agggcccgga aatcctggtg gaagccgcca aatggtgccg tccgctgcgc 1380
gcggcgctcg atacctgggg cgaggtgacc ttcaactacg cctccaccga cacgtccgat 1440
tacgtgccca ccgcgtccgt cgcctga 1467
<210> 3
<211> 488
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 3
Met Gly Ala Glu Ala Thr Val Gly Gln Ile Thr Asp Ala Lys Lys Arg
1 5 10 15
Tyr Ala Ala Gly Val Leu Lys Tyr Ala Gln Met Gly Tyr Trp Asn Gly
20 25 30
Asp Tyr Val Pro Lys Asp Thr Asp Leu Leu Ala Val Phe Arg Ile Thr
35 40 45
Pro Gln Ala Gly Val Asp Pro Val Glu Ala Ala Ala Ala Val Ala Gly
50 55 60
Glu Ser Ser Thr Ala Thr Trp Thr Val Val Trp Thr Asp Arg Leu Thr
65 70 75 80
Ala Ala Asp Val Tyr Arg Ala Lys Ala Tyr Lys Val Glu Pro Val Pro
85 90 95
Gly Gln Glu Gly Gln Tyr Phe Cys Tyr Ile Ala Tyr Asp Leu Asp Leu
100 105 110
Phe Glu Glu Gly Ser Ile Ala Asn Leu Thr Ala Ser Ile Ile Gly Asn
115 120 125
Val Phe Ser Phe Lys Pro Leu Lys Ala Ala Arg Leu Glu Asp Met Arg
130 135 140
Leu Pro Val Ala Tyr Val Lys Thr Phe Arg Gly Pro Pro Thr Gly Ile
145 150 155 160
Val Val Glu Arg Glu Arg Leu Asp Lys Phe Gly Arg Pro Leu Leu Gly
165 170 175
Ala Thr Thr Lys Pro Lys Leu Gly Leu Ser Gly Lys Asn Tyr Gly Arg
180 185 190
Val Val Tyr Glu Ala Leu Lys Gly Gly Leu Asp Phe Val Lys Asp Asp
195 200 205
Glu Asn Ile Asn Ser Gln Pro Phe Met His Trp Arg Asp Arg Phe Leu
210 215 220
Tyr Cys Met Glu Ala Val Asn Lys Ala Gln Ala Glu Thr Gly Glu Val
225 230 235 240
Lys Gly His Tyr Leu Asn Ile Thr Ala Gly Thr Met Glu Glu Met Tyr
245 250 255
Arg Arg Ala Glu Phe Ala Lys Glu Leu Gly Ser Val Val Val Met Val
260 265 270
Asp Leu Ile Ile Gly Trp Thr Ala Ile Gln Ser Met Ser Asn Trp Cys
275 280 285
Arg Glu Asn Asp Met Ile Leu His Met His Arg Ala Gly His Gly Thr
290 295 300
Tyr Thr Arg Gln Lys Ser His Gly Val Ser Phe Arg Val Ile Ala Lys
305 310 315 320
Trp Leu Arg Leu Ala Gly Val Asp His Leu His Thr Gly Thr Ala Val
325 330 335
Gly Lys Leu Glu Gly Asp Pro Met Thr Val Gln Gly Phe Tyr Asn Val
340 345 350
Cys Arg Glu Thr Thr Thr Gln Gln Asp Leu Thr Arg Gly Leu Phe Phe
355 360 365
Glu Gln Asp Trp Gly Gly Ile Arg Lys Val Met Pro Val Ala Ser Gly
370 375 380
Gly Ile His Ala Gly Gln Met His Gln Leu Ile Asp Leu Phe Gly Glu
385 390 395 400
Asp Val Val Leu Gln Phe Gly Gly Gly Thr Ile Gly His Pro Asp Gly
405 410 415
Ile Gln Ala Gly Ala Thr Ala Asn Arg Val Ala Leu Glu Thr Met Ile
420 425 430
Leu Ala Arg Asn Glu Gly Arg Asp Ile Arg Asn Glu Gly Pro Glu Ile
435 440 445
Leu Val Glu Ala Ala Lys Trp Cys Arg Pro Leu Arg Ala Ala Leu Asp
450 455 460
Thr Trp Gly Glu Val Thr Phe Asn Tyr Ala Ser Thr Asp Thr Ser Asp
465 470 475 480
Tyr Val Pro Thr Ala Ser Val Ala
485
<210> 4
<211> 405
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 4
atgcgcatca cccaaggctc cttctccttc ctgccggacc tcaccgacac gcagatcaag 60
gcccaggtgc aatattgcct ggaccagggc tgggcggtct cggtggagca caccgacgat 120
ccccacccgc gcaacaccta ttgggagatg tggggcccgc ccatgttcga tctgcgcgac 180
gcggccggcg tcttcggcga gatcgaagcc tgccgggccg ccaatcccga gcattatgtg 240
cgggtgaacg ccttcgattc cagccgcgga tgggagacga tccgcctgtc cttcatcgtt 300
cagcggccca ccgtggaaga gggcttccgc ctcgaccgca ccgaaggcaa gggccgcaac 360
cagagctacg ccatgcgcta ccgggcgcag ttcgcgccgc gctga 405
<210> 5
<211> 134
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 5
Met Arg Ile Thr Gln Gly Ser Phe Ser Phe Leu Pro Asp Leu Thr Asp
1 5 10 15
Thr Gln Ile Lys Ala Gln Val Gln Tyr Cys Leu Asp Gln Gly Trp Ala
20 25 30
Val Ser Val Glu His Thr Asp Asp Pro His Pro Arg Asn Thr Tyr Trp
35 40 45
Glu Met Trp Gly Pro Pro Met Phe Asp Leu Arg Asp Ala Ala Gly Val
50 55 60
Phe Gly Glu Ile Glu Ala Cys Arg Ala Ala Asn Pro Glu His Tyr Val
65 70 75 80
Arg Val Asn Ala Phe Asp Ser Ser Arg Gly Trp Glu Thr Ile Arg Leu
85 90 95
Ser Phe Ile Val Gln Arg Pro Thr Val Glu Glu Gly Phe Arg Leu Asp
100 105 110
Arg Thr Glu Gly Lys Gly Arg Asn Gln Ser Tyr Ala Met Arg Tyr Arg
115 120 125
Ala Gln Phe Ala Pro Arg
130
<210> 6
<211> 1896
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 6
atgatgccat ctgagccgca cggcgcgggc atgccgcccc cacgggaagc ggccgcggtt 60
cccacccccc aggaggtgag cgcggtggtg gccgaggtgg tcgcggatgc cgtggcatcg 120
gtgggcggcg cacgcacccg gctcatggac atcgtccagc tggcccagca gcgtctcggc 180
catctctccg aagagaccat ggcggccatt gccgcgcggc tcgccattcc gccggtggaa 240
gtggcggaca tggtgtcctt ctacgccttc ctgaaccgcg cgcccaaggg ccgctaccac 300
atccgcctgt cgcgcagccc catctcgctg atgaagggcg ccgaggcggt ggctgccgcc 360
ttctgccaga tcctcggcat cgccatgggc gagacctcgc aggatggcga cttcaccctg 420
gaatggacca acgacatcgg catggccgac caggagccgg ccgccctcgt caacggcacg 480
gtgatgacgc agctcgcgcc cggcgatgcg gccatcatcg tcggccggct gcgggcccat 540
cacgcgccca atgccctgcc gctgttccct ggagccggcg tggccggctc cggcctgccc 600
catgcccgga tccgccccag cctggtgatg ccgggacagc ttctgttccg cgaggaccac 660
acgacgccgg gcgccggcat caaggcggca ctcgccctca ccccggacga agtggtgcag 720
aaggtctccg ccgcgcgcct gcgcgggcgg ggtggcgccg gctttcccac cggtctcaaa 780
tggaagctct gccgccagtc gcccgccacc acccgccatg tgatctgcaa tgcggacgag 840
ggcgagcccg gcaccttcaa ggatcgcgtg ctgctcacgc aggcgccgca cctcatgttc 900
gacggcatga ccatcgccgg ctacgccttg ggggcgcggg agggcgtggt ctatctgcgc 960
ggcgagtacg cctatctgtg ggagcctctg catgcggtcc tgcgcgagcg ctatgggctc 1020
gggctcgccg gcgcgaacat cctgggacac gcgggcttcg acttcgacat ccgcatccag 1080
ctgggcgccg gcgcctatat ctgcggcgag gaatccgcgc tggtggaatc gctggaaggc 1140
aagcgcggct cgccccgcga ccgccccccc ttccccaccg tgcgcggcca tctccagcag 1200
cccaccgccg tggacaatgt ggagaccttc gcctgcgccg cccgcatcct ggaggatggc 1260
gtggaggcgt tcgcgggcat cggcacgccc gaatccgccg gcacgaagct cctctcggtg 1320
tcgggcgatt gcccgcgccc cggcgtgtat gaggtgccct tcggcctcac ggtgaacgcg 1380
ctgctcgacc ttgtcggcgc gccggacgcc gccttcgtgc agatgggtgg gccgtccggc 1440
caatgcgtgg cgccgaagga ttacggccgc cgcatcgcct tcgaggacct gcccaccggc 1500
ggctcggtga tggtgttcgg cccggggcgc gacgtgctcg ccatggtgcg cgagttcgcg 1560
gatttcttcg ccggcgaatc ctgcggctgg tgcacgccct gccgggtggg caccaccttg 1620
ctcaaggaag agctggacaa gctcctcgcc aaccgcgcca ccctcgccga catccgcgcg 1680
ctggagaccc tggccacgac cgtctcccgc accagccgct gcggcctcgg ccagacggcg 1740
cccaacccca tcctttccac catgcgcaac ctgccggaag cctatgaggc gaggctgagg 1800
cccgaagact tcctgccctg ggcctcgctc gacgaggcgc tgaagcccgc catcgtcatc 1860
cagggccgcg cgcccgtgcc ggaggaagag gcatga 1896
<210> 7
<211> 631
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 7
Met Met Pro Ser Glu Pro His Gly Ala Gly Met Pro Pro Pro Arg Glu
1 5 10 15
Ala Ala Ala Val Pro Thr Pro Gln Glu Val Ser Ala Val Val Ala Glu
20 25 30
Val Val Ala Asp Ala Val Ala Ser Val Gly Gly Ala Arg Thr Arg Leu
35 40 45
Met Asp Ile Val Gln Leu Ala Gln Gln Arg Leu Gly His Leu Ser Glu
50 55 60
Glu Thr Met Ala Ala Ile Ala Ala Arg Leu Ala Ile Pro Pro Val Glu
65 70 75 80
Val Ala Asp Met Val Ser Phe Tyr Ala Phe Leu Asn Arg Ala Pro Lys
85 90 95
Gly Arg Tyr His Ile Arg Leu Ser Arg Ser Pro Ile Ser Leu Met Lys
100 105 110
Gly Ala Glu Ala Val Ala Ala Ala Phe Cys Gln Ile Leu Gly Ile Ala
115 120 125
Met Gly Glu Thr Ser Gln Asp Gly Asp Phe Thr Leu Glu Trp Thr Asn
130 135 140
Asp Ile Gly Met Ala Asp Gln Glu Pro Ala Ala Leu Val Asn Gly Thr
145 150 155 160
Val Met Thr Gln Leu Ala Pro Gly Asp Ala Ala Ile Ile Val Gly Arg
165 170 175
Leu Arg Ala His His Ala Pro Asn Ala Leu Pro Leu Phe Pro Gly Ala
180 185 190
Gly Val Ala Gly Ser Gly Leu Pro His Ala Arg Ile Arg Pro Ser Leu
195 200 205
Val Met Pro Gly Gln Leu Leu Phe Arg Glu Asp His Thr Thr Pro Gly
210 215 220
Ala Gly Ile Lys Ala Ala Leu Ala Leu Thr Pro Asp Glu Val Val Gln
225 230 235 240
Lys Val Ser Ala Ala Arg Leu Arg Gly Arg Gly Gly Ala Gly Phe Pro
245 250 255
Thr Gly Leu Lys Trp Lys Leu Cys Arg Gln Ser Pro Ala Thr Thr Arg
260 265 270
His Val Ile Cys Asn Ala Asp Glu Gly Glu Pro Gly Thr Phe Lys Asp
275 280 285
Arg Val Leu Leu Thr Gln Ala Pro His Leu Met Phe Asp Gly Met Thr
290 295 300
Ile Ala Gly Tyr Ala Leu Gly Ala Arg Glu Gly Val Val Tyr Leu Arg
305 310 315 320
Gly Glu Tyr Ala Tyr Leu Trp Glu Pro Leu His Ala Val Leu Arg Glu
325 330 335
Arg Tyr Gly Leu Gly Leu Ala Gly Ala Asn Ile Leu Gly His Ala Gly
340 345 350
Phe Asp Phe Asp Ile Arg Ile Gln Leu Gly Ala Gly Ala Tyr Ile Cys
355 360 365
Gly Glu Glu Ser Ala Leu Val Glu Ser Leu Glu Gly Lys Arg Gly Ser
370 375 380
Pro Arg Asp Arg Pro Pro Phe Pro Thr Val Arg Gly His Leu Gln Gln
385 390 395 400
Pro Thr Ala Val Asp Asn Val Glu Thr Phe Ala Cys Ala Ala Arg Ile
405 410 415
Leu Glu Asp Gly Val Glu Ala Phe Ala Gly Ile Gly Thr Pro Glu Ser
420 425 430
Ala Gly Thr Lys Leu Leu Ser Val Ser Gly Asp Cys Pro Arg Pro Gly
435 440 445
Val Tyr Glu Val Pro Phe Gly Leu Thr Val Asn Ala Leu Leu Asp Leu
450 455 460
Val Gly Ala Pro Asp Ala Ala Phe Val Gln Met Gly Gly Pro Ser Gly
465 470 475 480
Gln Cys Val Ala Pro Lys Asp Tyr Gly Arg Arg Ile Ala Phe Glu Asp
485 490 495
Leu Pro Thr Gly Gly Ser Val Met Val Phe Gly Pro Gly Arg Asp Val
500 505 510
Leu Ala Met Val Arg Glu Phe Ala Asp Phe Phe Ala Gly Glu Ser Cys
515 520 525
Gly Trp Cys Thr Pro Cys Arg Val Gly Thr Thr Leu Leu Lys Glu Glu
530 535 540
Leu Asp Lys Leu Leu Ala Asn Arg Ala Thr Leu Ala Asp Ile Arg Ala
545 550 555 560
Leu Glu Thr Leu Ala Thr Thr Val Ser Arg Thr Ser Arg Cys Gly Leu
565 570 575
Gly Gln Thr Ala Pro Asn Pro Ile Leu Ser Thr Met Arg Asn Leu Pro
580 585 590
Glu Ala Tyr Glu Ala Arg Leu Arg Pro Glu Asp Phe Leu Pro Trp Ala
595 600 605
Ser Leu Asp Glu Ala Leu Lys Pro Ala Ile Val Ile Gln Gly Arg Ala
610 615 620
Pro Val Pro Glu Glu Glu Ala
625 630
<210> 8
<211> 1491
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 8
atgagccggg gatcccccga tgccgggaaa gaccgcacca tgagcgccac cgacggcacc 60
accgcccccc gcaagatcgt catcgatccg gtgacccgcg tggagggcca cggcaaggtc 120
accatccgcc tggatgaagc cggcgcggtg gaggatgcgc gtttccacat cgtggagttc 180
cgcggcttcg agcggttcat ccagggccgg atgtactggg aagtgcccct tatcatccag 240
cggctgtgcg gcatctgccc ggtgagccac catctggcgg cggcgaaagc catggaccag 300
gtggcgggcg tggaccgcgt accgcccacc gccgagaaac tgcgccggct gatgcattat 360
gggcaggtgc tgcaatccaa cgctttgcac atcttccacc tcgcctcgcc cgacctcctg 420
ttcggcttcg acgcgccggc cgagcagcgc aacatcatcg ccgtgctcca gcgttatccg 480
gagatcggca aatgggcgat cttcatcagg aagttcggcc aggaggtcat caaggccacc 540
ggcgggcgca agatccatcc caccagcgcc attcccggcg gggtcaacca gaacctcgcc 600
gtggaggacc gcgacgccct gcgcgccaag gtgggcgaga tcatcagctg gtgcatggcg 660
gcgctggacc atcacaaggc ctatgtggcg gaaaaccggg cgctgcatga cagcttcgcc 720
gccttcccct ccgccttcat gagcctcgtg gggccggatg gcggcatgga cctttatgac 780
ggcaccctgc gggtgatcga tgccgagggc gcccccctca tcgaaggcgc gccgcccgcc 840
tcctaccgcg accacctcat cgaggaggtg cggccctgga gctatctgaa attcccccat 900
ctgcgcgcct tcggccgcga cgatggctgg tatcgggtcg gccccctcgc ccaggtcaat 960
tgcgccgcgt ccatcgacac gccccgcgcc gaggcggccc ggcgggactt catggccgag 1020
ggcggcggca agccggtgca tgccaccctc gcttatcact gggcgcggct catcgtgctg 1080
gtccattgcg cggagaagat cgaacagctg ctgttcgacg acgacctgca aggctgcgat 1140
ctgcgtgcgg agggcacccg gcgcggggaa ggcgtcgcct ggatcgaggc gccgcgcggc 1200
accctcatcc accattacga ggtggacgag aacgaccagg tgcgccgcgc caacctcatc 1260
gtctccacca cccacaataa cgaggccatg aaccgcgccg tgcggcaggt ggcgaagacg 1320
gacctttccg gtcgcgagat caccgaaggg ctgctgaacc atatcgaggt ggccatccgc 1380
gccttcgacc cctgcctgtc ctgcgccacc catgcgctgg gccagatgcc gctgatcgtg 1440
acgcttgaag atgcctccgg cgcagagatc gcccgcggag tgaaggaatg a 1491
<210> 9
<211> 496
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 9
Met Ser Arg Gly Ser Pro Asp Ala Gly Lys Asp Arg Thr Met Ser Ala
1 5 10 15
Thr Asp Gly Thr Thr Ala Pro Arg Lys Ile Val Ile Asp Pro Val Thr
20 25 30
Arg Val Glu Gly His Gly Lys Val Thr Ile Arg Leu Asp Glu Ala Gly
35 40 45
Ala Val Glu Asp Ala Arg Phe His Ile Val Glu Phe Arg Gly Phe Glu
50 55 60
Arg Phe Ile Gln Gly Arg Met Tyr Trp Glu Val Pro Leu Ile Ile Gln
65 70 75 80
Arg Leu Cys Gly Ile Cys Pro Val Ser His His Leu Ala Ala Ala Lys
85 90 95
Ala Met Asp Gln Val Ala Gly Val Asp Arg Val Pro Pro Thr Ala Glu
100 105 110
Lys Leu Arg Arg Leu Met His Tyr Gly Gln Val Leu Gln Ser Asn Ala
115 120 125
Leu His Ile Phe His Leu Ala Ser Pro Asp Leu Leu Phe Gly Phe Asp
130 135 140
Ala Pro Ala Glu Gln Arg Asn Ile Ile Ala Val Leu Gln Arg Tyr Pro
145 150 155 160
Glu Ile Gly Lys Trp Ala Ile Phe Ile Arg Lys Phe Gly Gln Glu Val
165 170 175
Ile Lys Ala Thr Gly Gly Arg Lys Ile His Pro Thr Ser Ala Ile Pro
180 185 190
Gly Gly Val Asn Gln Asn Leu Ala Val Glu Asp Arg Asp Ala Leu Arg
195 200 205
Ala Lys Val Gly Glu Ile Ile Ser Trp Cys Met Ala Ala Leu Asp His
210 215 220
His Lys Ala Tyr Val Ala Glu Asn Arg Ala Leu His Asp Ser Phe Ala
225 230 235 240
Ala Phe Pro Ser Ala Phe Met Ser Leu Val Gly Pro Asp Gly Gly Met
245 250 255
Asp Leu Tyr Asp Gly Thr Leu Arg Val Ile Asp Ala Glu Gly Ala Pro
260 265 270
Leu Ile Glu Gly Ala Pro Pro Ala Ser Tyr Arg Asp His Leu Ile Glu
275 280 285
Glu Val Arg Pro Trp Ser Tyr Leu Lys Phe Pro His Leu Arg Ala Phe
290 295 300
Gly Arg Asp Asp Gly Trp Tyr Arg Val Gly Pro Leu Ala Gln Val Asn
305 310 315 320
Cys Ala Ala Ser Ile Asp Thr Pro Arg Ala Glu Ala Ala Arg Arg Asp
325 330 335
Phe Met Ala Glu Gly Gly Gly Lys Pro Val His Ala Thr Leu Ala Tyr
340 345 350
His Trp Ala Arg Leu Ile Val Leu Val His Cys Ala Glu Lys Ile Glu
355 360 365
Gln Leu Leu Phe Asp Asp Asp Leu Gln Gly Cys Asp Leu Arg Ala Glu
370 375 380
Gly Thr Arg Arg Gly Glu Gly Val Ala Trp Ile Glu Ala Pro Arg Gly
385 390 395 400
Thr Leu Ile His His Tyr Glu Val Asp Glu Asn Asp Gln Val Arg Arg
405 410 415
Ala Asn Leu Ile Val Ser Thr Thr His Asn Asn Glu Ala Met Asn Arg
420 425 430
Ala Val Arg Gln Val Ala Lys Thr Asp Leu Ser Gly Arg Glu Ile Thr
435 440 445
Glu Gly Leu Leu Asn His Ile Glu Val Ala Ile Arg Ala Phe Asp Pro
450 455 460
Cys Leu Ser Cys Ala Thr His Ala Leu Gly Gln Met Pro Leu Ile Val
465 470 475 480
Thr Leu Glu Asp Ala Ser Gly Ala Glu Ile Ala Arg Gly Val Lys Glu
485 490 495
<210> 10
<211> 720
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 10
atgagcgaga cccccttcac ctttaccgtg gacggcatcg cggtcccggc cacccccggc 60
cagagcgtca tcgaggcgtg cgatgcggcg ggcatctata tcccgcgcct gtgccaccac 120
ccggacctgc cgccggcggg ccattgccgg gtgtgcacct gcatcatcga cgggcggccg 180
gccagcgcct gcaccatgcc cgccgccagg ggcatggtgg tggagaacga gacgcccgct 240
ttgctggcgg agcggcgcac gctgatcgag atgctgttcg cggaaggcaa ccatttctgc 300
cagttctgcg aggcgagcgg cgattgcgaa ttgcaggcgc tgggctacct gttcggcatg 360
gtggccccgc ccttccccca tctgtggccg aagcggccgg tggatgccag ccatccggat 420
atctatatcg accacaatcg ctgcatcctg tgctcgcgct gcgtgcgcgc ctcgcgcacc 480
ctggacggca agtccgtgtt cggcttcgag gggcgcggca tcgagatgca tctggcggtg 540
accggcgggc acctggacga cagcgccatc gccgccgccg acagggcggt tgagatgtgc 600
ccggtgggct gcatcgtcct caagcgcacc ggctaccgca cgccctatgg ccggcggcgc 660
tacgacgccg cgcccatcgg ctccgacatc accgcccggc gcggcggcgc gaaggactga 720
<210> 11
<211> 239
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 11
Met Ser Glu Thr Pro Phe Thr Phe Thr Val Asp Gly Ile Ala Val Pro
1 5 10 15
Ala Thr Pro Gly Gln Ser Val Ile Glu Ala Cys Asp Ala Ala Gly Ile
20 25 30
Tyr Ile Pro Arg Leu Cys His His Pro Asp Leu Pro Pro Ala Gly His
35 40 45
Cys Arg Val Cys Thr Cys Ile Ile Asp Gly Arg Pro Ala Ser Ala Cys
50 55 60
Thr Met Pro Ala Ala Arg Gly Met Val Val Glu Asn Glu Thr Pro Ala
65 70 75 80
Leu Leu Ala Glu Arg Arg Thr Leu Ile Glu Met Leu Phe Ala Glu Gly
85 90 95
Asn His Phe Cys Gln Phe Cys Glu Ala Ser Gly Asp Cys Glu Leu Gln
100 105 110
Ala Leu Gly Tyr Leu Phe Gly Met Val Ala Pro Pro Phe Pro His Leu
115 120 125
Trp Pro Lys Arg Pro Val Asp Ala Ser His Pro Asp Ile Tyr Ile Asp
130 135 140
His Asn Arg Cys Ile Leu Cys Ser Arg Cys Val Arg Ala Ser Arg Thr
145 150 155 160
Leu Asp Gly Lys Ser Val Phe Gly Phe Glu Gly Arg Gly Ile Glu Met
165 170 175
His Leu Ala Val Thr Gly Gly His Leu Asp Asp Ser Ala Ile Ala Ala
180 185 190
Ala Asp Arg Ala Val Glu Met Cys Pro Val Gly Cys Ile Val Leu Lys
195 200 205
Arg Thr Gly Tyr Arg Thr Pro Tyr Gly Arg Arg Arg Tyr Asp Ala Ala
210 215 220
Pro Ile Gly Ser Asp Ile Thr Ala Arg Arg Gly Gly Ala Lys Asp
225 230 235
<210> 12
<211> 543
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 12
atggccaagc ccaaactcgc cacctgcgcg ctggccggct gcttcggctg ccacatgtcc 60
ttcctggaca tggacgagcg catcgtcgag ctcatcgacc tggtggacct cgacgtctcg 120
cccctcgacg acaagaaaaa cttcaccggc atggtggaaa tcggcctggt ggaaggcggc 180
tgcgccgacg agcgccatgt gaaggtgctg cgcgagttcc gcgagaaatc ccgcatcctg 240
gtggcggtgg gcgcctgcgc catcaccggc ggcatcccgg cattgcgcaa cctcgccggc 300
ctcgacgaat gcctgaggga agcctacctc accggcccca cggtggaagg cggcgggctc 360
attcccaacg acccggagct gccgctgctg ctggacaagg tctatccggt gcaggacttc 420
gtgaagatcg accatttcct gcccggctgc ccgccctcgg ccgacgccat ctgggcggct 480
ctgaaggcgc tgctgaccgg caccgagccg catctgccct acccgctttt caagtacgaa 540
tga 543
<210> 13
<211> 180
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 13
Met Ala Lys Pro Lys Leu Ala Thr Cys Ala Leu Ala Gly Cys Phe Gly
1 5 10 15
Cys His Met Ser Phe Leu Asp Met Asp Glu Arg Ile Val Glu Leu Ile
20 25 30
Asp Leu Val Asp Leu Asp Val Ser Pro Leu Asp Asp Lys Lys Asn Phe
35 40 45
Thr Gly Met Val Glu Ile Gly Leu Val Glu Gly Gly Cys Ala Asp Glu
50 55 60
Arg His Val Lys Val Leu Arg Glu Phe Arg Glu Lys Ser Arg Ile Leu
65 70 75 80
Val Ala Val Gly Ala Cys Ala Ile Thr Gly Gly Ile Pro Ala Leu Arg
85 90 95
Asn Leu Ala Gly Leu Asp Glu Cys Leu Arg Glu Ala Tyr Leu Thr Gly
100 105 110
Pro Thr Val Glu Gly Gly Gly Leu Ile Pro Asn Asp Pro Glu Leu Pro
115 120 125
Leu Leu Leu Asp Lys Val Tyr Pro Val Gln Asp Phe Val Lys Ile Asp
130 135 140
His Phe Leu Pro Gly Cys Pro Pro Ser Ala Asp Ala Ile Trp Ala Ala
145 150 155 160
Leu Lys Ala Leu Leu Thr Gly Thr Glu Pro His Leu Pro Tyr Pro Leu
165 170 175
Phe Lys Tyr Glu
180
<210> 14
<211> 1013
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 14
tccagacccg ggcaacattg ctccatgtgc tgggcaccct ggccggccgc tggccccata 60
ccctcgcgct ccagcccggc ggggtgaccc gaagcgccga ccagcacgac cgcatgcgcc 120
tgctcgcgac gctgaaggcg gtgcgggcgg cgctggaaga gaccttgttc ggcgcgcctt 180
tggaagaggt ggcggccctg gacggcgccg ccgccgtgga ggcctggcgc gccaacggcc 240
cggaagggga tttccgcctg ttcctggaga tcgccgccga cctggagctg gaccggctcg 300
gccgcgcgca cgaccgcttt ctctccttcg gcgcctacgc ccaggacgag gggcgccttt 360
atggcgccgg caccttcgag gccgggacgg cgggagggct cgatcccaac gccatcaccg 420
aggaccacgc cttcgcccgc atggaggacc gcgcggcgcc ccatgcgccc tttgacggct 480
ccaccttccc cgatgccgac gacaccgagg gctacacctg gtgcaaggcg ccgcgccttg 540
ccggcctgcc cttcgagacc ggcgccttcg cccggcaggt ggtggcgggc catccgctcg 600
cccgggacct cgtgacgcgg gaaggcggca ctgtgcgcag ccgcgtggtc ggccggctgc 660
tggaaaccgc gcgcaccctg atcgccatgg agggctgggt gaaggaactg cggcccgaag 720
ggccctggtg cgcccagggc cacctgcccc aggaaggccg cgccttcggc ctcaccgagg 780
cggcgcgcgg ggcgctcggc cactggatgg tggtggagaa gggccgcatt gcccgctacc 840
agatcatcgc ccccaccacc tggaacttct ccccccgcga cggcgcgggc ctgcccggcc 900
cgctggagac ggccctggtg ggcgcgcccg tgcggcaggg agagacgacg cccgtgagcg 960
tgcagcacat cgtgcgctcc ttcgacccgt gcatggtctg cactgtgcat tga 1013
<210> 15
<211> 485
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 15
Met Ser Ala Glu Thr Arg Arg Leu Val Val Gly Pro Phe Asn Arg Val
1 5 10 15
Glu Gly Asp Leu Glu Val Arg Leu Asp Val Gln Asp Gly Arg Val Gln
20 25 30
Gln Ala Phe Val Ser Ser Pro Leu Phe Arg Gly Phe Glu Arg Ile Leu
35 40 45
Glu Gly Arg Asp Pro Arg Asp Ala Leu Val Ile Ala Pro Arg Ile Cys
50 55 60
Gly Ile Cys Ser Val Ser Gln Ser His Ala Ala Ala Leu Ala Leu Ala
65 70 75 80
Gly Leu Gln Gly Ile Ala Pro Thr His Asp Gly Arg Ile Ala Thr Asn
85 90 95
Leu Ile Val Ala Ala Glu Asn Val Ala Asp His Leu Thr His Phe His
100 105 110
Val Phe Phe Met Pro Asp Phe Ala Arg Ala Val Tyr Glu Asp Arg Pro
115 120 125
Trp Phe Ala Gln Ala Ala Arg Arg Phe Lys Ala Asn Gln Gly Val Ser
130 135 140
Val Arg Arg Ala Leu Gln Thr Arg Ala Thr Leu Leu His Val Leu Gly
145 150 155 160
Thr Leu Ala Gly Arg Trp Pro His Thr Leu Ala Leu Gln Pro Gly Gly
165 170 175
Val Thr Arg Ser Ala Asp Gln His Asp Arg Met Arg Leu Leu Ala Thr
180 185 190
Leu Lys Ala Val Arg Ala Ala Leu Glu Glu Thr Leu Phe Gly Ala Pro
195 200 205
Leu Glu Glu Val Ala Ala Leu Asp Gly Ala Ala Ala Val Glu Ala Trp
210 215 220
Arg Ala Asn Gly Pro Glu Gly Asp Phe Arg Leu Phe Leu Glu Ile Ala
225 230 235 240
Ala Asp Leu Glu Leu Asp Arg Leu Gly Arg Ala His Asp Arg Phe Leu
245 250 255
Ser Phe Gly Ala Tyr Ala Gln Asp Glu Gly Arg Leu Tyr Gly Ala Gly
260 265 270
Thr Phe Glu Ala Gly Thr Ala Gly Gly Leu Asp Pro Asn Ala Ile Thr
275 280 285
Glu Asp His Ala Phe Ala Arg Met Glu Asp Arg Ala Ala Pro His Ala
290 295 300
Pro Phe Asp Gly Ser Thr Phe Pro Asp Ala Asp Asp Thr Glu Gly Tyr
305 310 315 320
Thr Trp Cys Lys Ala Pro Arg Leu Ala Gly Leu Pro Phe Glu Thr Gly
325 330 335
Ala Phe Ala Arg Gln Val Val Ala Gly His Pro Leu Ala Arg Asp Leu
340 345 350
Val Thr Arg Glu Gly Gly Thr Val Arg Ser Arg Val Val Gly Arg Leu
355 360 365
Leu Glu Thr Ala Arg Thr Leu Ile Ala Met Glu Gly Trp Val Lys Glu
370 375 380
Leu Arg Pro Glu Gly Pro Trp Cys Ala Gln Gly His Leu Pro Gln Glu
385 390 395 400
Gly Arg Ala Phe Gly Leu Thr Glu Ala Ala Arg Gly Ala Leu Gly His
405 410 415
Trp Met Val Val Glu Lys Gly Arg Ile Ala Arg Tyr Gln Ile Ile Ala
420 425 430
Pro Thr Thr Trp Asn Phe Ser Pro Arg Asp Gly Ala Gly Leu Pro Gly
435 440 445
Pro Leu Glu Thr Ala Leu Val Gly Ala Pro Val Arg Gln Gly Glu Thr
450 455 460
Thr Pro Val Ser Val Gln His Ile Val Arg Ser Phe Asp Pro Cys Met
465 470 475 480
Val Cys Thr Val His
485
<210> 16
<211> 858
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 16
acgggggagg aagcccgcgc catcttcgac gccatccttg ccggcgttat cgtcctcgac 60
gccctgtgcg tggaaggcgc gctgctgcgc gggccgaacg gcaccgggcg cttccatgtg 120
ctggcgggca cggacacccc caccatcgac tgggcgcggc agctcgccgg catggcgcgc 180
cacgtggtgg cggtgggcac ctgcgccgcc tatgggggcg tgacggcggc gggcatcaac 240
cccaccgatg cctgcggcct ccagttcgac ggacgccgga agggtggggc gctgggggcg 300
gacttccgct cccgctcggg gcttccggtc atcaatgtgg ccggctgccc cacccatccc 360
aactgggtga cggaaaccct gatgctgctc gcctgcggcc tgctgggcga ggccgacctc 420
gacgtctatg gccgcccgcg cttctatgcg gacctgctgg tgcatcacgg ctgcccgcgc 480
aacgaatact atgaatacaa ggcgagcgcc gagaagatga gcgacctcgg ctgcatgatg 540
gagcatctgg gctgcctcgg cacccaggcc cacgccgact gcaacacgcg cctttggaat 600
ggcgagggct cgtgcacccg cggcggctat gcctgcatca actgcacggc gccggaattc 660
gaggagccgg gccacgcctt cctggagacg cccaagatcg gcggcatccc catcggcctg 720
cccaccgaca tgcccaaggc ctggttcatc gccttgtcct ccctcgccaa ggcggcgacg 780
ccggagcggc tgcgcaagaa cgcggtgtcc gaccatgtgg tcacgccgcc cgccgtcaag 840
gacatcaagc ggcgatga 858
<210> 17
<211> 335
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 17
Met Ser Thr Pro Phe Ser Val Leu Trp Leu Gln Ser Gly Gly Cys Gly
1 5 10 15
Gly Cys Thr Met Ser Leu Leu Cys Ala Glu Ala Pro Asp Leu Ala Thr
20 25 30
Thr Leu Asp Ala Ala Gly Ile Gly Phe Leu Trp His Pro Ala Leu Ser
35 40 45
Glu Glu Thr Gly Glu Glu Ala Arg Ala Ile Phe Asp Ala Ile Leu Ala
50 55 60
Gly Val Ile Val Leu Asp Ala Leu Cys Val Glu Gly Ala Leu Leu Arg
65 70 75 80
Gly Pro Asn Gly Thr Gly Arg Phe His Val Leu Ala Gly Thr Asp Thr
85 90 95
Pro Thr Ile Asp Trp Ala Arg Gln Leu Ala Gly Met Ala Arg His Val
100 105 110
Val Ala Val Gly Thr Cys Ala Ala Tyr Gly Gly Val Thr Ala Ala Gly
115 120 125
Ile Asn Pro Thr Asp Ala Cys Gly Leu Gln Phe Asp Gly Arg Arg Lys
130 135 140
Gly Gly Ala Leu Gly Ala Asp Phe Arg Ser Arg Ser Gly Leu Pro Val
145 150 155 160
Ile Asn Val Ala Gly Cys Pro Thr His Pro Asn Trp Val Thr Glu Thr
165 170 175
Leu Met Leu Leu Ala Cys Gly Leu Leu Gly Glu Ala Asp Leu Asp Val
180 185 190
Tyr Gly Arg Pro Arg Phe Tyr Ala Asp Leu Leu Val His His Gly Cys
195 200 205
Pro Arg Asn Glu Tyr Tyr Glu Tyr Lys Ala Ser Ala Glu Lys Met Ser
210 215 220
Asp Leu Gly Cys Met Met Glu His Leu Gly Cys Leu Gly Thr Gln Ala
225 230 235 240
His Ala Asp Cys Asn Thr Arg Leu Trp Asn Gly Glu Gly Ser Cys Thr
245 250 255
Arg Gly Gly Tyr Ala Cys Ile Asn Cys Thr Ala Pro Glu Phe Glu Glu
260 265 270
Pro Gly His Ala Phe Leu Glu Thr Pro Lys Ile Gly Gly Ile Pro Ile
275 280 285
Gly Leu Pro Thr Asp Met Pro Lys Ala Trp Phe Ile Ala Leu Ser Ser
290 295 300
Leu Ala Lys Ala Ala Thr Pro Glu Arg Leu Arg Lys Asn Ala Val Ser
305 310 315 320
Asp His Val Val Thr Pro Pro Ala Val Lys Asp Ile Lys Arg Arg
325 330 335
<210> 18
<211> 870
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 18
gtgaccgagc gcctgtccga cgtcaacgcc cgcatcgcct cggtgcggca gctctcatcg 60
gtcatcacgg ccatgcgggg cattgcggcg gcgcgggcgc gggaggcgcg gggtcggctc 120
gacggcatcc gcgcctatgc gcagaccatc gccgaggcca tcggccatgt gctcgccgtg 180
ctgcccgagg aggcccgcgc ccggtcctcc gggcaccggc atcggggcca tgcggtcatc 240
gccctgtgcg cggagcaggg ctttgccggc gtcttcaacg agcgggtgct ggacgaggcc 300
gcccggctgc tgaccggcgg ggcggggccg gccgagctgc tgctggtggg cgaccggggc 360
ctgatggtgg cccgcgagcg ggggctcgat gtctcctggt cggtgcccat ggtggcccat 420
gcgggccagg cctcggcgct ggcggaccgc atcagcgagg agctctaccg gcggatcgat 480
gcgggacggg tgacgcgggt gtcggtggtg cacgccgagc ccgccgcgtc cgccgccatc 540
gagacggtgg tgaaagtgct ggtgccgttc gacttcgccc gcttccccct ggcgcgggtg 600
gcatccgccc cgctcatgac catgccgccg ccgcggctgc tggcccagct gtcggaggaa 660
tatgtgttcg ccgagctgtg cgaggcgctc accttgtcct tcgcggcgga gaacgaggcc 720
cgcatgcggg ccatgatcgc cgcccgcgcc aatgtggccg ataccctgga gggcctcgtc 780
ggccgcgccc ggcagatgcg ccaggaggag atcaccaacg agatcatcga gctggaaggc 840
ggcgccggca gcgcccggca tgcggattga 870
<210> 19
<211> 289
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 19
Met Thr Glu Arg Leu Ser Asp Val Asn Ala Arg Ile Ala Ser Val Arg
1 5 10 15
Gln Leu Ser Ser Val Ile Thr Ala Met Arg Gly Ile Ala Ala Ala Arg
20 25 30
Ala Arg Glu Ala Arg Gly Arg Leu Asp Gly Ile Arg Ala Tyr Ala Gln
35 40 45
Thr Ile Ala Glu Ala Ile Gly His Val Leu Ala Val Leu Pro Glu Glu
50 55 60
Ala Arg Ala Arg Ser Ser Gly His Arg His Arg Gly His Ala Val Ile
65 70 75 80
Ala Leu Cys Ala Glu Gln Gly Phe Ala Gly Val Phe Asn Glu Arg Val
85 90 95
Leu Asp Glu Ala Ala Arg Leu Leu Thr Gly Gly Ala Gly Pro Ala Glu
100 105 110
Leu Leu Leu Val Gly Asp Arg Gly Leu Met Val Ala Arg Glu Arg Gly
115 120 125
Leu Asp Val Ser Trp Ser Val Pro Met Val Ala His Ala Gly Gln Ala
130 135 140
Ser Ala Leu Ala Asp Arg Ile Ser Glu Glu Leu Tyr Arg Arg Ile Asp
145 150 155 160
Ala Gly Arg Val Thr Arg Val Ser Val Val His Ala Glu Pro Ala Ala
165 170 175
Ser Ala Ala Ile Glu Thr Val Val Lys Val Leu Val Pro Phe Asp Phe
180 185 190
Ala Arg Phe Pro Leu Ala Arg Val Ala Ser Ala Pro Leu Met Thr Met
195 200 205
Pro Pro Pro Arg Leu Leu Ala Gln Leu Ser Glu Glu Tyr Val Phe Ala
210 215 220
Glu Leu Cys Glu Ala Leu Thr Leu Ser Phe Ala Ala Glu Asn Glu Ala
225 230 235 240
Arg Met Arg Ala Met Ile Ala Ala Arg Ala Asn Val Ala Asp Thr Leu
245 250 255
Glu Gly Leu Val Gly Arg Ala Arg Gln Met Arg Gln Glu Glu Ile Thr
260 265 270
Asn Glu Ile Ile Glu Leu Glu Gly Gly Ala Gly Ser Ala Arg His Ala
275 280 285
Asp
<210> 20
<211> 1536
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 20
atgagcacgg gcgcgcaagc gagcgaggat tggctcaccc ggagccgggc ggccctggcc 60
gggacgcgcc tttcccagca atcccaatcg gtgggccggg tggaggagat ggccgacggc 120
atcgcccgcg tctccggcct gccggatgtg cggctcgacg agcttctcac cttcgagggc 180
ggccagaccg gctatgccct caccctcgat cgcaccgaga tcgccgtggt gctgctggat 240
gacgcctccg gcgtggaggc gggcgcccgg gtgttcggca ccggcgaggt ggtgaaggtg 300
ccggtggggc cggggctgct gggccgcatc gtcgaccccc tcggccggcc catggaccgc 360
tccgagccgg tggtggcgca ggcgcaccat cccatcgagc ggccggcgcc ggccatcatc 420
gcccgcgacc tggtctcgca gccggttcag accggcacgc tggtggtgga tgcgctgttc 480
tccctcggcc ggggccagcg cgagctcatc atcggcgacc gggctaccgg caagaccgcc 540
atcgcggtgg acaccatcat cagccagaag cattcggaca tcgtgtgcat ctacgtggcg 600
gtgggccagc gcgccgccgc cgtggagcgg gtggtggagg cggtgcgcgc ccacggggcg 660
atcgagcgct gcatcttcgt ggtcgcctcg gccgccgcct cgccagggct gcaatggatc 720
gcgccgttcg ccggcatgac catggcggaa tatttccgcg acaacggcca gcatgcgctc 780
atcatcatcg atgatctcac caagcatgcg gccacccatc gcgagctggc gctgctcacc 840
cacgagccgc cgggccgcga ggcctatccc ggcgacatct tctatgtgca cgcccgcctt 900
ctggagcggg ccgccaagct ctccgccgag ctgggcggtg gctcgctcac ggccctgccc 960
atcgcggaga cggacgcggg aaacctctcc gcctatatcc ccaccaacct catctccatc 1020
accgatgggc agatcgtgct ggattcgcgg ctgttcgcgg ccaaccagcg cccggcggtg 1080
gatgtgggcc tctccgtgag ccgggtgggc ggcaaggcgc agcatcccgc gcttcgggcc 1140
gtgtccgggc gcatccggct cgattattcc cagttcctgg agctggaaat gttcacccgc 1200
ttcggcggca tcaccgatac ccgcgtgaag gcgcagatca cccggggcga gcgcatccgc 1260
gcgctgctca cccagccgcg cttttccacc ctgcgccttc aggacgaggt ggcgctgctg 1320
gccgcgctgg cggagggggt gttcgacact ttggccccgg ggctgatggg cgccgtgcgt 1380
gcccgcattc cggcccagct ggatgcgcag gtgaaggacg tggcctcggc cctcgccgag 1440
ggcaaggtgc tggaggaggg cttgcacgcc cgtctcgtgg cggccgtgcg ggccgtcgcg 1500
gcggacgtgg ccgcgaccgc gaaggccggg ccgtga 1536
<210> 21
<211> 511
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 21
Met Ser Thr Gly Ala Gln Ala Ser Glu Asp Trp Leu Thr Arg Ser Arg
1 5 10 15
Ala Ala Leu Ala Gly Thr Arg Leu Ser Gln Gln Ser Gln Ser Val Gly
20 25 30
Arg Val Glu Glu Met Ala Asp Gly Ile Ala Arg Val Ser Gly Leu Pro
35 40 45
Asp Val Arg Leu Asp Glu Leu Leu Thr Phe Glu Gly Gly Gln Thr Gly
50 55 60
Tyr Ala Leu Thr Leu Asp Arg Thr Glu Ile Ala Val Val Leu Leu Asp
65 70 75 80
Asp Ala Ser Gly Val Glu Ala Gly Ala Arg Val Phe Gly Thr Gly Glu
85 90 95
Val Val Lys Val Pro Val Gly Pro Gly Leu Leu Gly Arg Ile Val Asp
100 105 110
Pro Leu Gly Arg Pro Met Asp Arg Ser Glu Pro Val Val Ala Gln Ala
115 120 125
His His Pro Ile Glu Arg Pro Ala Pro Ala Ile Ile Ala Arg Asp Leu
130 135 140
Val Ser Gln Pro Val Gln Thr Gly Thr Leu Val Val Asp Ala Leu Phe
145 150 155 160
Ser Leu Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Ala Thr
165 170 175
Gly Lys Thr Ala Ile Ala Val Asp Thr Ile Ile Ser Gln Lys His Ser
180 185 190
Asp Ile Val Cys Ile Tyr Val Ala Val Gly Gln Arg Ala Ala Ala Val
195 200 205
Glu Arg Val Val Glu Ala Val Arg Ala His Gly Ala Ile Glu Arg Cys
210 215 220
Ile Phe Val Val Ala Ser Ala Ala Ala Ser Pro Gly Leu Gln Trp Ile
225 230 235 240
Ala Pro Phe Ala Gly Met Thr Met Ala Glu Tyr Phe Arg Asp Asn Gly
245 250 255
Gln His Ala Leu Ile Ile Ile Asp Asp Leu Thr Lys His Ala Ala Thr
260 265 270
His Arg Glu Leu Ala Leu Leu Thr His Glu Pro Pro Gly Arg Glu Ala
275 280 285
Tyr Pro Gly Asp Ile Phe Tyr Val His Ala Arg Leu Leu Glu Arg Ala
290 295 300
Ala Lys Leu Ser Ala Glu Leu Gly Gly Gly Ser Leu Thr Ala Leu Pro
305 310 315 320
Ile Ala Glu Thr Asp Ala Gly Asn Leu Ser Ala Tyr Ile Pro Thr Asn
325 330 335
Leu Ile Ser Ile Thr Asp Gly Gln Ile Val Leu Asp Ser Arg Leu Phe
340 345 350
Ala Ala Asn Gln Arg Pro Ala Val Asp Val Gly Leu Ser Val Ser Arg
355 360 365
Val Gly Gly Lys Ala Gln His Pro Ala Leu Arg Ala Val Ser Gly Arg
370 375 380
Ile Arg Leu Asp Tyr Ser Gln Phe Leu Glu Leu Glu Met Phe Thr Arg
385 390 395 400
Phe Gly Gly Ile Thr Asp Thr Arg Val Lys Ala Gln Ile Thr Arg Gly
405 410 415
Glu Arg Ile Arg Ala Leu Leu Thr Gln Pro Arg Phe Ser Thr Leu Arg
420 425 430
Leu Gln Asp Glu Val Ala Leu Leu Ala Ala Leu Ala Glu Gly Val Phe
435 440 445
Asp Thr Leu Ala Pro Gly Leu Met Gly Ala Val Arg Ala Arg Ile Pro
450 455 460
Ala Gln Leu Asp Ala Gln Val Lys Asp Val Ala Ser Ala Leu Ala Glu
465 470 475 480
Gly Lys Val Leu Glu Glu Gly Leu His Ala Arg Leu Val Ala Ala Val
485 490 495
Arg Ala Val Ala Ala Asp Val Ala Ala Thr Ala Lys Ala Gly Pro
500 505 510
<210> 22
<211> 741
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 22
atgcagatcg actggtggac gctgggcctg cagacggtca acgtcctcgt tctcatctgg 60
ctcctgagcc gcttcctgtt caagccggtg gcgcaggtca tcgcgcagcg ccgtgccgag 120
atcgagaagc tggtggagga tgcgcgcgcc gccaaggccg ccgccgaggc cgagcgggac 180
acggcgaagg cggaggaggc gcgccttgcc gccgagcgcg gcgcccgcat ggcggcggtc 240
gccaaggagg cggaggcgca gaaggcggca ttgctggccg ccgccaagac cgaggccgag 300
gccctgcacg cggccgcgga agcggccatc gtccgggcgc gggcgagcga ggaggaagcc 360
gccgccgacc gcgccagccg ccttgccgtg gacatcgccg ccaagctgct ggaccggctg 420
cccgacgacg cccgggtcgc gggcttcatc gatggcctcg ccgaggggct tgaagccctg 480
cccgaggcga gccgggcggt gatcggcgtc gacggcgcgc cagtgcgcgt gacggccgcg 540
cgcgccctta tgccggcgga ggaggaggcc tgccgcacgc ggctctccca ggcgctgggc 600
cgtccggtga cgctggccgt gaccatcgac cccgccctca tcgccggcct ggagatggag 660
acgccccacg cggtggtgcg caattccttc aaggccgatc tcgaccgcgt caccgcggcg 720
ctcacccatc atgggacctg a 741
<210> 23
<211> 246
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 23
Met Gln Ile Asp Trp Trp Thr Leu Gly Leu Gln Thr Val Asn Val Leu
1 5 10 15
Val Leu Ile Trp Leu Leu Ser Arg Phe Leu Phe Lys Pro Val Ala Gln
20 25 30
Val Ile Ala Gln Arg Arg Ala Glu Ile Glu Lys Leu Val Glu Asp Ala
35 40 45
Arg Ala Ala Lys Ala Ala Ala Glu Ala Glu Arg Asp Thr Ala Lys Ala
50 55 60
Glu Glu Ala Arg Leu Ala Ala Glu Arg Gly Ala Arg Met Ala Ala Val
65 70 75 80
Ala Lys Glu Ala Glu Ala Gln Lys Ala Ala Leu Leu Ala Ala Ala Lys
85 90 95
Thr Glu Ala Glu Ala Leu His Ala Ala Ala Glu Ala Ala Ile Val Arg
100 105 110
Ala Arg Ala Ser Glu Glu Glu Ala Ala Ala Asp Arg Ala Ser Arg Leu
115 120 125
Ala Val Asp Ile Ala Ala Lys Leu Leu Asp Arg Leu Pro Asp Asp Ala
130 135 140
Arg Val Ala Gly Phe Ile Asp Gly Leu Ala Glu Gly Leu Glu Ala Leu
145 150 155 160
Pro Glu Ala Ser Arg Ala Val Ile Gly Val Asp Gly Ala Pro Val Arg
165 170 175
Val Thr Ala Ala Arg Ala Leu Met Pro Ala Glu Glu Glu Ala Cys Arg
180 185 190
Thr Arg Leu Ser Gln Ala Leu Gly Arg Pro Val Thr Leu Ala Val Thr
195 200 205
Ile Asp Pro Ala Leu Ile Ala Gly Leu Glu Met Glu Thr Pro His Ala
210 215 220
Val Val Arg Asn Ser Phe Lys Ala Asp Leu Asp Arg Val Thr Ala Ala
225 230 235 240
Leu Thr His His Gly Thr
245
<210> 24
<211> 243
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 24
atgactgtcg agatggtcag catcttcgcg gcggcgctcg ccgtctcctt cggcgccatc 60
gggccggccc tgggcgaggg ccgggcggtg gccgcggcca tggacgccat cgcccgccag 120
ccggaggcgg ccggaacctt gtcgcgcacg ctcttcgtcg gcctcgccat gatcgagacc 180
atggcgatct actgcctggt gatcgcgctc ctggtgctct tcgccaatcc gttcgtgaag 240
tga 243
<210> 25
<211> 80
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 25
Met Thr Val Glu Met Val Ser Ile Phe Ala Ala Ala Leu Ala Val Ser
1 5 10 15
Phe Gly Ala Ile Gly Pro Ala Leu Gly Glu Gly Arg Ala Val Ala Ala
20 25 30
Ala Met Asp Ala Ile Ala Arg Gln Pro Glu Ala Ala Gly Thr Leu Ser
35 40 45
Arg Thr Leu Phe Val Gly Leu Ala Met Ile Glu Thr Met Ala Ile Tyr
50 55 60
Cys Leu Val Ile Ala Leu Leu Val Leu Phe Ala Asn Pro Phe Val Lys
65 70 75 80
<210> 26
<211> 699
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 26
atgggctcgc cgctgatcct cgaacccctg ttccatatcg ggcccgtgcc catcaccgcg 60
ccggtggtgg tcacctggct catcatggcc gccttcattg ggctggcgcg gctcatcacc 120
cggaagcttt ccaccgatcc cacccggacc caggcggcgg tggaaacggt gctgaccgcc 180
atcgattccc agatcgccga caccatgcag gccgatcccg cgccttatcg cgcgctcatc 240
ggcaccatct tcctttatgt gctggtggcc aactggtcct cgctcatccc gggcatcgag 300
ccgcccacgg cgcatatcga gaccgatgcg gcgctcgctt tcatcgtgtt cgccgccacc 360
atcgggttcg ggttgaagac aaggggtgtg aagggctatc tcgccacctt cgccgaaccc 420
tcctgggtga tgatcccgct caatgtggtg gagcagatca cccggacctt ctcgctcatc 480
gtgcgcctgt tcggcaacat catgagcggg gtgttcgtgg tcggcatcat cctgtccctc 540
gccgggctgc tggtgcccat ccccctcatg gcgctcgatc tcctgaccgg cgccgtgcag 600
gcctacatct tcgcggtgct ggcctgcgtg ttcatcggcg cggccattgg cgaggcgccg 660
gcaaagcccc aatcgaagga gccagggaaa acatcatga 699
<210> 27
<211> 232
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 27
Met Gly Ser Pro Leu Ile Leu Glu Pro Leu Phe His Ile Gly Pro Val
1 5 10 15
Pro Ile Thr Ala Pro Val Val Val Thr Trp Leu Ile Met Ala Ala Phe
20 25 30
Ile Gly Leu Ala Arg Leu Ile Thr Arg Lys Leu Ser Thr Asp Pro Thr
35 40 45
Arg Thr Gln Ala Ala Val Glu Thr Val Leu Thr Ala Ile Asp Ser Gln
50 55 60
Ile Ala Asp Thr Met Gln Ala Asp Pro Ala Pro Tyr Arg Ala Leu Ile
65 70 75 80
Gly Thr Ile Phe Leu Tyr Val Leu Val Ala Asn Trp Ser Ser Leu Ile
85 90 95
Pro Gly Ile Glu Pro Pro Thr Ala His Ile Glu Thr Asp Ala Ala Leu
100 105 110
Ala Phe Ile Val Phe Ala Ala Thr Ile Gly Phe Gly Leu Lys Thr Arg
115 120 125
Gly Val Lys Gly Tyr Leu Ala Thr Phe Ala Glu Pro Ser Trp Val Met
130 135 140
Ile Pro Leu Asn Val Val Glu Gln Ile Thr Arg Thr Phe Ser Leu Ile
145 150 155 160
Val Arg Leu Phe Gly Asn Ile Met Ser Gly Val Phe Val Val Gly Ile
165 170 175
Ile Leu Ser Leu Ala Gly Leu Leu Val Pro Ile Pro Leu Met Ala Leu
180 185 190
Asp Leu Leu Thr Gly Ala Val Gln Ala Tyr Ile Phe Ala Val Leu Ala
195 200 205
Cys Val Phe Ile Gly Ala Ala Ile Gly Glu Ala Pro Ala Lys Pro Gln
210 215 220
Ser Lys Glu Pro Gly Lys Thr Ser
225 230
<210> 28
<211> 456
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 28
gtgagcgcgc cgctgcacct caccatcacc acgccggccg ccgttctggt ggaccgtgcc 60
gacatcgtgg ccctgcgtgc cgaggacgag agcggcagct tcggcatcct gcccggccat 120
gcggatttcc tgaccgttct ggaggcctgc gtggtgcgct tcaaggatgg ggccgacggc 180
gtgcattatt gtgctctcag tggtggcgtg ctgtcggtcg aggagggccg gcgcatcgcc 240
atcgcctgcc gtcagggcac ggtgagcgac gacctggtcg ccctggaagg ggcggtggac 300
gccatgcgtt cggcggagag cgatgccgac aagcgggccc gggtggagca gatgcgcctt 360
catgcccacg ccgtgcgcca gctcctgcac tatctgcggc ccggccgggc cggcggcgtg 420
gcgccggccg ccgcgccgga ggaggggccg tcatga 456
<210> 29
<211> 151
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 29
Met Ser Ala Pro Leu His Leu Thr Ile Thr Thr Pro Ala Ala Val Leu
1 5 10 15
Val Asp Arg Ala Asp Ile Val Ala Leu Arg Ala Glu Asp Glu Ser Gly
20 25 30
Ser Phe Gly Ile Leu Pro Gly His Ala Asp Phe Leu Thr Val Leu Glu
35 40 45
Ala Cys Val Val Arg Phe Lys Asp Gly Ala Asp Gly Val His Tyr Cys
50 55 60
Ala Leu Ser Gly Gly Val Leu Ser Val Glu Glu Gly Arg Arg Ile Ala
65 70 75 80
Ile Ala Cys Arg Gln Gly Thr Val Ser Asp Asp Leu Val Ala Leu Glu
85 90 95
Gly Ala Val Asp Ala Met Arg Ser Ala Glu Ser Asp Ala Asp Lys Arg
100 105 110
Ala Arg Val Glu Gln Met Arg Leu His Ala His Ala Val Arg Gln Leu
115 120 125
Leu His Tyr Leu Arg Pro Gly Arg Ala Gly Gly Val Ala Pro Ala Ala
130 135 140
Ala Pro Glu Glu Gly Pro Ser
145 150
<210> 30
<211> 1494
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 30
atggcagcgg cagatgagga ggcgcaatcg gccgccggcc ccgcctcggg ccgggtggtg 60
gccgtgcgcg gcgcggtgat cgacatcgcc tttgcccagc ctccgctgcc gccgctggac 120
gacgcccttc tcatcaccga cggccggggc ggcacggtgc tggtggaggt gcagagccat 180
atggatcggc acacggtgcg cgccatcgcc cttcaggcca ccaccggcct cagccggggg 240
ctggaggcgg cgcgggtggg cgggccggtg aaggtgccgg tgggagacca tgtgctcggc 300
cgcctcctgg atgtcaccgg cgccatcggc gacaagggcg ggccgctgcc ggccgacgtg 360
cccacgcggc cgatccacca cgcgccgcca tccttcgccg cgcagggcgg cacgtccgat 420
ctgtttcgca ccggcatcaa ggtcatcgac ctcctggcgc ccctcgccca gggcggcaag 480
gcggccatgt tcggcggggc cggcgtgggc aagaccgtgc tggtgatgga gctgatccac 540
gccatggtgg cgagctacaa gggcatctcg gtgtttgccg gcgtggggga gcgctcccgc 600
gagggccacg agatgctgct ggacatgacc gattccggcg tgctcgaccg caccgttctg 660
gtctatggcc agatgaacga gccccccggg gcccgctggc gggtgcccat gacggcgctg 720
accatcgccg aatatttccg cgacgagaag caccagaacg tcctgctgct gatggacaac 780
atcttccgct tcgtccaggc gggggcggag gtctccggcc ttttgggccg tccgccctcc 840
cgggtgggat accagccgac gctggcgagc gaggtggcgg cgctccagga acgcatcacc 900
tccgtgggcg aggcctcggt gaccgccatc gaggcggtct acgtgccggc ggatgacttc 960
accgatcccg ccgtgaccac catcgccgcc cacgtggatt ccatggtggt gctctcccgc 1020
gccatggcgg cggagggcat gtatccggcg gtggacccca tctcctcctc gtcggtgctg 1080
ctcgacccgc tcatcgtggg ggacgagcat gcgcgcgtcg ccaacgaggt gcgccggacc 1140
atcgagcatt atcgcgagct tcaggatgtg atctcgctgc tgggcatgga ggaattgggc 1200
accgaggatc gccgcatcgt ggagcgggcg cgccggctcc agcgcttcct cacccagccc 1260
ttcacggtca ccgaggcctt caccggcgtg cccggccgct cggtggccat cgccgacacc 1320
atcgccggct gcaggatgat cctgtccggc gcctgcgacg actggcagga aagcgccctc 1380
tacatggtgg gcaccatcga cgaggcccgc cagaaggagg aggccgctcg cgccaaggcg 1440
gggcagggcg ccccggccgg gacggcagcc gagacggcgg aggccgcccc gtga 1494
<210> 31
<211> 497
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 31
Met Ala Ala Ala Asp Glu Glu Ala Gln Ser Ala Ala Gly Pro Ala Ser
1 5 10 15
Gly Arg Val Val Ala Val Arg Gly Ala Val Ile Asp Ile Ala Phe Ala
20 25 30
Gln Pro Pro Leu Pro Pro Leu Asp Asp Ala Leu Leu Ile Thr Asp Gly
35 40 45
Arg Gly Gly Thr Val Leu Val Glu Val Gln Ser His Met Asp Arg His
50 55 60
Thr Val Arg Ala Ile Ala Leu Gln Ala Thr Thr Gly Leu Ser Arg Gly
65 70 75 80
Leu Glu Ala Ala Arg Val Gly Gly Pro Val Lys Val Pro Val Gly Asp
85 90 95
His Val Leu Gly Arg Leu Leu Asp Val Thr Gly Ala Ile Gly Asp Lys
100 105 110
Gly Gly Pro Leu Pro Ala Asp Val Pro Thr Arg Pro Ile His His Ala
115 120 125
Pro Pro Ser Phe Ala Ala Gln Gly Gly Thr Ser Asp Leu Phe Arg Thr
130 135 140
Gly Ile Lys Val Ile Asp Leu Leu Ala Pro Leu Ala Gln Gly Gly Lys
145 150 155 160
Ala Ala Met Phe Gly Gly Ala Gly Val Gly Lys Thr Val Leu Val Met
165 170 175
Glu Leu Ile His Ala Met Val Ala Ser Tyr Lys Gly Ile Ser Val Phe
180 185 190
Ala Gly Val Gly Glu Arg Ser Arg Glu Gly His Glu Met Leu Leu Asp
195 200 205
Met Thr Asp Ser Gly Val Leu Asp Arg Thr Val Leu Val Tyr Gly Gln
210 215 220
Met Asn Glu Pro Pro Gly Ala Arg Trp Arg Val Pro Met Thr Ala Leu
225 230 235 240
Thr Ile Ala Glu Tyr Phe Arg Asp Glu Lys His Gln Asn Val Leu Leu
245 250 255
Leu Met Asp Asn Ile Phe Arg Phe Val Gln Ala Gly Ala Glu Val Ser
260 265 270
Gly Leu Leu Gly Arg Pro Pro Ser Arg Val Gly Tyr Gln Pro Thr Leu
275 280 285
Ala Ser Glu Val Ala Ala Leu Gln Glu Arg Ile Thr Ser Val Gly Glu
290 295 300
Ala Ser Val Thr Ala Ile Glu Ala Val Tyr Val Pro Ala Asp Asp Phe
305 310 315 320
Thr Asp Pro Ala Val Thr Thr Ile Ala Ala His Val Asp Ser Met Val
325 330 335
Val Leu Ser Arg Ala Met Ala Ala Glu Gly Met Tyr Pro Ala Val Asp
340 345 350
Pro Ile Ser Ser Ser Ser Val Leu Leu Asp Pro Leu Ile Val Gly Asp
355 360 365
Glu His Ala Arg Val Ala Asn Glu Val Arg Arg Thr Ile Glu His Tyr
370 375 380
Arg Glu Leu Gln Asp Val Ile Ser Leu Leu Gly Met Glu Glu Leu Gly
385 390 395 400
Thr Glu Asp Arg Arg Ile Val Glu Arg Ala Arg Arg Leu Gln Arg Phe
405 410 415
Leu Thr Gln Pro Phe Thr Val Thr Glu Ala Phe Thr Gly Val Pro Gly
420 425 430
Arg Ser Val Ala Ile Ala Asp Thr Ile Ala Gly Cys Arg Met Ile Leu
435 440 445
Ser Gly Ala Cys Asp Asp Trp Gln Glu Ser Ala Leu Tyr Met Val Gly
450 455 460
Thr Ile Asp Glu Ala Arg Gln Lys Glu Glu Ala Ala Arg Ala Lys Ala
465 470 475 480
Gly Gln Gly Ala Pro Ala Gly Thr Ala Ala Glu Thr Ala Glu Ala Ala
485 490 495
Pro
<210> 32
<211> 1437
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 32
atggcgaaca aggtcggacg catcacccag atcatcggcg ccgtcgtcga cgtgcagttc 60
gacgggcatc tgccggcgat tctcaacgcg atcgagacca ccaaccaggg caaccggctg 120
gtgctcgaag tggctcagca tctcggcgag aacaccgtgc gctgcatcgc catggatgcc 180
actgaaggcc tggtgcgtgg ccaggaggtg gccgacaccg atgcgcccat ccaggtgccc 240
gtgggcgccg ccaccctcgg ccgcatcatg aacgtgatcg gcgagccggt ggacgagctg 300
ggccccatcg agggcgaagc gctgcgcggc atccatcagc cggccccctc ctatgcggag 360
caggccacgg aagctgagat cctcgtcacc ggcatcaagg tggtggatct gctggcgccc 420
tattccaagg gcggcaaggt gggcctgttc ggcggcgccg gcgtgggcaa gaccgtgctc 480
atcatggagc tgatcaacaa cgtggccaag gcgcacggcg gctattccgt gttcgccggc 540
gtgggtgagc gcacccgcga gggcaacgac ctctaccacg agatgatcga gtccaacgtg 600
aacaaggacc cgcacgagaa caatggctcg gcggccggtt ccaagtgcgc cctggtctat 660
ggccagatga acgagccgcc cggcgcccgc gcccgcgtgg ccctcaccgg cctcaccgtc 720
gccgagcatt tccgcgacca gggccaggac gtgctgttct tcgtggacaa catcttccgc 780
ttcacccagg cgggctccga ggtgtcggcg cttctcggcc gcatcccctc ggcggtgggc 840
taccagccga cgctggccac cgacatgggc cagctgcagg agcgcatcac caccaccacc 900
aagggctcca tcacctcggt gcaggccatc tacgtgccgg cggacgatct gaccgatccg 960
gcgccggccg cctccttcgc ccatctggac gccaccacgg tgctgtcgcg ctccatcgcg 1020
gagaagggca tctacccggc ggtggatccg ctggactcca cctcgcgcat gctgtctccc 1080
gccatcctcg gcgacgagca ctacaacacc gcgcgccagg tgcagcagac cctgcagcgc 1140
tacaaggcgc tccaggacat catcgccatc ctgggcatgg acgaactctc cgaagaggac 1200
aagctcaccg tggcccgcgc ccgcaagatc gagcgcttcc tctcccagcc cttccacgtg 1260
gccgaggtgt tcaccggttc gcccggcaag ctggtcgacc tcgccgacac catcaagggc 1320
ttcaagggcc tggtggacgg caagtacgac tacctgcccg agcaggcctt ctacatggtg 1380
ggcaccatcg aagaagccat cgagaagggc aagaagctgg cggccgaggc ggcctga 1437
<210> 33
<211> 478
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 33
Met Ala Asn Lys Val Gly Arg Ile Thr Gln Ile Ile Gly Ala Val Val
1 5 10 15
Asp Val Gln Phe Asp Gly His Leu Pro Ala Ile Leu Asn Ala Ile Glu
20 25 30
Thr Thr Asn Gln Gly Asn Arg Leu Val Leu Glu Val Ala Gln His Leu
35 40 45
Gly Glu Asn Thr Val Arg Cys Ile Ala Met Asp Ala Thr Glu Gly Leu
50 55 60
Val Arg Gly Gln Glu Val Ala Asp Thr Asp Ala Pro Ile Gln Val Pro
65 70 75 80
Val Gly Ala Ala Thr Leu Gly Arg Ile Met Asn Val Ile Gly Glu Pro
85 90 95
Val Asp Glu Leu Gly Pro Ile Glu Gly Glu Ala Leu Arg Gly Ile His
100 105 110
Gln Pro Ala Pro Ser Tyr Ala Glu Gln Ala Thr Glu Ala Glu Ile Leu
115 120 125
Val Thr Gly Ile Lys Val Val Asp Leu Leu Ala Pro Tyr Ser Lys Gly
130 135 140
Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly Lys Thr Val Leu
145 150 155 160
Ile Met Glu Leu Ile Asn Asn Val Ala Lys Ala His Gly Gly Tyr Ser
165 170 175
Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly Asn Asp Leu Tyr
180 185 190
His Glu Met Ile Glu Ser Asn Val Asn Lys Asp Pro His Glu Asn Asn
195 200 205
Gly Ser Ala Ala Gly Ser Lys Cys Ala Leu Val Tyr Gly Gln Met Asn
210 215 220
Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr Val
225 230 235 240
Ala Glu His Phe Arg Asp Gln Gly Gln Asp Val Leu Phe Phe Val Asp
245 250 255
Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala Leu Leu
260 265 270
Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala Thr Asp
275 280 285
Met Gly Gln Leu Gln Glu Arg Ile Thr Thr Thr Thr Lys Gly Ser Ile
290 295 300
Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr Asp Pro
305 310 315 320
Ala Pro Ala Ala Ser Phe Ala His Leu Asp Ala Thr Thr Val Leu Ser
325 330 335
Arg Ser Ile Ala Glu Lys Gly Ile Tyr Pro Ala Val Asp Pro Leu Asp
340 345 350
Ser Thr Ser Arg Met Leu Ser Pro Ala Ile Leu Gly Asp Glu His Tyr
355 360 365
Asn Thr Ala Arg Gln Val Gln Gln Thr Leu Gln Arg Tyr Lys Ala Leu
370 375 380
Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu Glu Asp
385 390 395 400
Lys Leu Thr Val Ala Arg Ala Arg Lys Ile Glu Arg Phe Leu Ser Gln
405 410 415
Pro Phe His Val Ala Glu Val Phe Thr Gly Ser Pro Gly Lys Leu Val
420 425 430
Asp Leu Ala Asp Thr Ile Lys Gly Phe Lys Gly Leu Val Asp Gly Lys
435 440 445
Tyr Asp Tyr Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Thr Ile Glu
450 455 460
Glu Ala Ile Glu Lys Gly Lys Lys Leu Ala Ala Glu Ala Ala
465 470 475
<210> 34
<211> 876
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 34
atggcgagtc tgaaggacct gagaaaccgc attgcctcgg tgaaggcgac gcagaagatc 60
accaaggcga tgcagatggt cgccgcggcg aagctgcgtc gcgcccaggc ggcggctgaa 120
gcggcccgtc cctatgcgga acgcatggag acggtgctcg gaaatcttgc ctccggcatg 180
gtggtgggcg cgcaggcgcc tgttctcatg accgggacgg gcaagagcga cacccacctg 240
ctgctggtgt gcaccggcga gcgcggcctg tgcggcgcct tcaactcgtc catcgtgcgc 300
ttcgcccgcg agcgggcgca gctgctgctg gccgagggca agaaggtgaa aatcctgtgc 360
gtgggccgca agggccacga gcagctgcgc cgcatctacc cggacaacat catcgacgtg 420
gtggacctgc gcgcggtgcg caacatcggc ttcaaggagg ccgacgccat cgcccgcaag 480
gtgctggccc tgctcgatga aggcgcattc gacgtctgca cgctcttcta ctcccacttc 540
aggagcgtga tcgcccaggt gccgacggcc cagcagctca ttccggccac cttcgacgag 600
cggccggccg tcgccgatgc gccggtctat gaatatgagc cggaggagga ggagatcctc 660
gccgagctgc tgccgcgcaa cgtggcggtg cagatcttca aggccctcct cgagaaccag 720
gcttctttct atggctccca gatgagcgcc atggacaacg ccacgcgcaa tgcgggcgag 780
atgatcaaga agcagacgct cacctacaac cgtacccgcc aggccatgat cacgaaggaa 840
ctcatcgaga tcatctccgg cgccgaggcc gtctga 876
<210> 35
<211> 291
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 35
Met Ala Ser Leu Lys Asp Leu Arg Asn Arg Ile Ala Ser Val Lys Ala
1 5 10 15
Thr Gln Lys Ile Thr Lys Ala Met Gln Met Val Ala Ala Ala Lys Leu
20 25 30
Arg Arg Ala Gln Ala Ala Ala Glu Ala Ala Arg Pro Tyr Ala Glu Arg
35 40 45
Met Glu Thr Val Leu Gly Asn Leu Ala Ser Gly Met Val Val Gly Ala
50 55 60
Gln Ala Pro Val Leu Met Thr Gly Thr Gly Lys Ser Asp Thr His Leu
65 70 75 80
Leu Leu Val Cys Thr Gly Glu Arg Gly Leu Cys Gly Ala Phe Asn Ser
85 90 95
Ser Ile Val Arg Phe Ala Arg Glu Arg Ala Gln Leu Leu Leu Ala Glu
100 105 110
Gly Lys Lys Val Lys Ile Leu Cys Val Gly Arg Lys Gly His Glu Gln
115 120 125
Leu Arg Arg Ile Tyr Pro Asp Asn Ile Ile Asp Val Val Asp Leu Arg
130 135 140
Ala Val Arg Asn Ile Gly Phe Lys Glu Ala Asp Ala Ile Ala Arg Lys
145 150 155 160
Val Leu Ala Leu Leu Asp Glu Gly Ala Phe Asp Val Cys Thr Leu Phe
165 170 175
Tyr Ser His Phe Arg Ser Val Ile Ala Gln Val Pro Thr Ala Gln Gln
180 185 190
Leu Ile Pro Ala Thr Phe Asp Glu Arg Pro Ala Val Ala Asp Ala Pro
195 200 205
Val Tyr Glu Tyr Glu Pro Glu Glu Glu Glu Ile Leu Ala Glu Leu Leu
210 215 220
Pro Arg Asn Val Ala Val Gln Ile Phe Lys Ala Leu Leu Glu Asn Gln
225 230 235 240
Ala Ser Phe Tyr Gly Ser Gln Met Ser Ala Met Asp Asn Ala Thr Arg
245 250 255
Asn Ala Gly Glu Met Ile Lys Lys Gln Thr Leu Thr Tyr Asn Arg Thr
260 265 270
Arg Gln Ala Met Ile Thr Lys Glu Leu Ile Glu Ile Ile Ser Gly Ala
275 280 285
Glu Ala Val
290
<210> 36
<211> 1530
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 36
atggacattc gagccgctga aatctctgcc atcctgaaag agcagatcca gaatttcggc 60
caggaggcgg aagtctccga ggtgggtcag gttctgtccg tgggtgacgg catcgcgcgc 120
gtctacggcc tcgacaacgt ccaggcgggc gagatggtcg agttcgagaa cggcacgcgc 180
ggcatggcgc tgaacctcga gctcgacaat gtcggcatcg tgatcttcgg ttccgaccgc 240
gagatcaagg aaggccagac cgtcaagcgg accggcgcca tcgtggacgc ccccgtcggc 300
aagggcctgc tcggccgcgt cgtggacgct ctcggcaacc cgatcgacgg caagggcccg 360
atcatgttca ccgagcgtcg ccgggtcgac gtgaaggcgc cgggcatcat cccgcgcaag 420
tcggtgcacg agcccatgca gaccggcctg aaggccatcg atgcgctcat ccccatcggc 480
cgcggccagc gcgagctcat catcggcgac cgccagaccg gcaagaccgc cgtggcgctc 540
gactcgatcc tgaaccagaa gcccatcaac cagggcgacg acgagaaggc caagctctac 600
tgcgtctatg tcgcggtggg ccagaagcgt tccactgtcg cgcagttcgt gaaggtgctc 660
gaggagcacg gcgcgctgga atattccatc gtcgtcgccg ccaccgcctc ggacgcggcc 720
cccatgcagt tcctggcgcc gttcaccggc accgccatgg gcgagtattt ccgcgacaac 780
ggcatgcacg ccctcatcat ccatgatgac ctgtccaagc aggccgtggc ctaccgccag 840
atgtcgctgc tgctgcgccg cccgccgggc cgcgaggcct atcccggcga tgtgttctac 900
ctgcactccc gcctcttgga gcgcgccgcc aagctcaatg acgagcacgg cgccggctcg 960
ctgaccgccc tgccggtgat cgagacccag gccaacgacg tgtcggccta catcccgacc 1020
aacgtgatct ccatcaccga cggtcagatc ttccttgaat ccgatctgtt ctaccagggc 1080
atccgcccgg cggtgaacgt gggcctgtcg gtgtcgcgcg tgggctcttc ggcccagatc 1140
aaggcgatga agcaggtggc cggcaagatc aagggcgagc tcgcccagta tcgcgagctg 1200
gcggccttcg cccagttcgg ttcggacctg gacgcggcca cccagaagct gctgaaccgc 1260
ggcgcccgcc tcaccgagct gctgaagcag agccagttct cgcccctcaa ggtggaggag 1320
caggtggcgg tgatctatgc cggcaccaat ggctatctcg atccgctgcc ggtctccaag 1380
gtgcgcgagt tcgagcaggg tctgctcctg tcgctgcgct cgcagcatcc ggagatcctg 1440
gacgccatcc gcacgtccaa ggagctttcc aaggacaccg ccgagaagct gacgaaggcc 1500
atcgacgcct tcgccaagag cttctcctga 1530
<210> 37
<211> 509
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 37
Met Asp Ile Arg Ala Ala Glu Ile Ser Ala Ile Leu Lys Glu Gln Ile
1 5 10 15
Gln Asn Phe Gly Gln Glu Ala Glu Val Ser Glu Val Gly Gln Val Leu
20 25 30
Ser Val Gly Asp Gly Ile Ala Arg Val Tyr Gly Leu Asp Asn Val Gln
35 40 45
Ala Gly Glu Met Val Glu Phe Glu Asn Gly Thr Arg Gly Met Ala Leu
50 55 60
Asn Leu Glu Leu Asp Asn Val Gly Ile Val Ile Phe Gly Ser Asp Arg
65 70 75 80
Glu Ile Lys Glu Gly Gln Thr Val Lys Arg Thr Gly Ala Ile Val Asp
85 90 95
Ala Pro Val Gly Lys Gly Leu Leu Gly Arg Val Val Asp Ala Leu Gly
100 105 110
Asn Pro Ile Asp Gly Lys Gly Pro Ile Met Phe Thr Glu Arg Arg Arg
115 120 125
Val Asp Val Lys Ala Pro Gly Ile Ile Pro Arg Lys Ser Val His Glu
130 135 140
Pro Met Gln Thr Gly Leu Lys Ala Ile Asp Ala Leu Ile Pro Ile Gly
145 150 155 160
Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr
165 170 175
Ala Val Ala Leu Asp Ser Ile Leu Asn Gln Lys Pro Ile Asn Gln Gly
180 185 190
Asp Asp Glu Lys Ala Lys Leu Tyr Cys Val Tyr Val Ala Val Gly Gln
195 200 205
Lys Arg Ser Thr Val Ala Gln Phe Val Lys Val Leu Glu Glu His Gly
210 215 220
Ala Leu Glu Tyr Ser Ile Val Val Ala Ala Thr Ala Ser Asp Ala Ala
225 230 235 240
Pro Met Gln Phe Leu Ala Pro Phe Thr Gly Thr Ala Met Gly Glu Tyr
245 250 255
Phe Arg Asp Asn Gly Met His Ala Leu Ile Ile His Asp Asp Leu Ser
260 265 270
Lys Gln Ala Val Ala Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro
275 280 285
Pro Gly Arg Glu Ala Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg
290 295 300
Leu Leu Glu Arg Ala Ala Lys Leu Asn Asp Glu His Gly Ala Gly Ser
305 310 315 320
Leu Thr Ala Leu Pro Val Ile Glu Thr Gln Ala Asn Asp Val Ser Ala
325 330 335
Tyr Ile Pro Thr Asn Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu
340 345 350
Glu Ser Asp Leu Phe Tyr Gln Gly Ile Arg Pro Ala Val Asn Val Gly
355 360 365
Leu Ser Val Ser Arg Val Gly Ser Ser Ala Gln Ile Lys Ala Met Lys
370 375 380
Gln Val Ala Gly Lys Ile Lys Gly Glu Leu Ala Gln Tyr Arg Glu Leu
385 390 395 400
Ala Ala Phe Ala Gln Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Lys
405 410 415
Leu Leu Asn Arg Gly Ala Arg Leu Thr Glu Leu Leu Lys Gln Ser Gln
420 425 430
Phe Ser Pro Leu Lys Val Glu Glu Gln Val Ala Val Ile Tyr Ala Gly
435 440 445
Thr Asn Gly Tyr Leu Asp Pro Leu Pro Val Ser Lys Val Arg Glu Phe
450 455 460
Glu Gln Gly Leu Leu Leu Ser Leu Arg Ser Gln His Pro Glu Ile Leu
465 470 475 480
Asp Ala Ile Arg Thr Ser Lys Glu Leu Ser Lys Asp Thr Ala Glu Lys
485 490 495
Leu Thr Lys Ala Ile Asp Ala Phe Ala Lys Ser Phe Ser
500 505
<210> 38
<211> 555
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 38
gtggcggaaa cgatcgtgtc aggcatggcg ggacgctatg cgaccgcgct gttcgagctg 60
gcggacgaag ccggtgccat cgattccgtc caggcggatc ttgatcgcct gtccggcctt 120
ctggccgaga gcgcggatct ggcgcggctg gtcaagagcc cggtcttcac cgccgagcag 180
cagctcggcg cgatggcggc cattctcgat caagcaggca tttccggcct tgcgggcaaa 240
ttcgtgaagc tggtggcgca gaaccgccgc ctgttcgcac tgccgcgcat gattgccgaa 300
tacgccgtcc tggtggcccg gaagaagggc gagacctcgg cgagcgtgac cgttgccacc 360
cccctgagcg atgagcatct ggccacgctc aaggcggccc tggctgaaaa gaccggcaag 420
gacgtgaagc tcgacgtcac cgtcgatccg tccatcctcg gtggtctcat cgtgaagctc 480
ggctcgcgca tggtcgatgc ttccctgaag accaaactca attctatccg gcatgcgatg 540
aaagaggtcc gctga 555
<210> 39
<211> 184
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 39
Met Ala Glu Thr Ile Val Ser Gly Met Ala Gly Arg Tyr Ala Thr Ala
1 5 10 15
Leu Phe Glu Leu Ala Asp Glu Ala Gly Ala Ile Asp Ser Val Gln Ala
20 25 30
Asp Leu Asp Arg Leu Ser Gly Leu Leu Ala Glu Ser Ala Asp Leu Ala
35 40 45
Arg Leu Val Lys Ser Pro Val Phe Thr Ala Glu Gln Gln Leu Gly Ala
50 55 60
Met Ala Ala Ile Leu Asp Gln Ala Gly Ile Ser Gly Leu Ala Gly Lys
65 70 75 80
Phe Val Lys Leu Val Ala Gln Asn Arg Arg Leu Phe Ala Leu Pro Arg
85 90 95
Met Ile Ala Glu Tyr Ala Val Leu Val Ala Arg Lys Lys Gly Glu Thr
100 105 110
Ser Ala Ser Val Thr Val Ala Thr Pro Leu Ser Asp Glu His Leu Ala
115 120 125
Thr Leu Lys Ala Ala Leu Ala Glu Lys Thr Gly Lys Asp Val Lys Leu
130 135 140
Asp Val Thr Val Asp Pro Ser Ile Leu Gly Gly Leu Ile Val Lys Leu
145 150 155 160
Gly Ser Arg Met Val Asp Ala Ser Leu Lys Thr Lys Leu Asn Ser Ile
165 170 175
Arg His Ala Met Lys Glu Val Arg
180
<210> 40
<211> 492
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 40
atgaccgaaa tggaactggc tgagctctgg gtcgccatcg ccttcctggt tttcgtaggc 60
ctcctgatct atgcgggcgc ccaccgcgcc atcgtctccg ccctggattc ccgcggctcg 120
cgcatcgcct cggaactgga ggaggcccgt cggctcaagg aagaggccca gaagctggtg 180
gccgaattca agcgcaagca gcgcgaggcc gaggccgagg ccgaatccat cgtcaccggc 240
gccaaggccg aggccgagcg cctcgccgcc gaggccaagg cgaagatcga ggatttcgtc 300
acccgccgca ccaagatggc cgaggacaag atcgcccagg ccgagcatca ggctctggcg 360
gacgtgaagt ccatcgccgc cgaggcggcg gccaaggcgg ccgaggtgat cctcggcgcc 420
caggccaccg gcgcggtggc ggagcgtctg ctgtcgggcg ccatctccga ggtcaagacc 480
aagctcaact ga 492
<210> 41
<211> 163
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 41
Met Thr Glu Met Glu Leu Ala Glu Leu Trp Val Ala Ile Ala Phe Leu
1 5 10 15
Val Phe Val Gly Leu Leu Ile Tyr Ala Gly Ala His Arg Ala Ile Val
20 25 30
Ser Ala Leu Asp Ser Arg Gly Ser Arg Ile Ala Ser Glu Leu Glu Glu
35 40 45
Ala Arg Arg Leu Lys Glu Glu Ala Gln Lys Leu Val Ala Glu Phe Lys
50 55 60
Arg Lys Gln Arg Glu Ala Glu Ala Glu Ala Glu Ser Ile Val Thr Gly
65 70 75 80
Ala Lys Ala Glu Ala Glu Arg Leu Ala Ala Glu Ala Lys Ala Lys Ile
85 90 95
Glu Asp Phe Val Thr Arg Arg Thr Lys Met Ala Glu Asp Lys Ile Ala
100 105 110
Gln Ala Glu His Gln Ala Leu Ala Asp Val Lys Ser Ile Ala Ala Glu
115 120 125
Ala Ala Ala Lys Ala Ala Glu Val Ile Leu Gly Ala Gln Ala Thr Gly
130 135 140
Ala Val Ala Glu Arg Leu Leu Ser Gly Ala Ile Ser Glu Val Lys Thr
145 150 155 160
Lys Leu Asn
<210> 42
<211> 729
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 42
atgatgattg catggaagcg gaccttcgca gtcgtgacct tcggggccgc cctgatggcc 60
atgcccgtcg cgggcgtggt cgcagctgag acttctcccg ctccggcggc agtggcgcag 120
gccgatcatg cggtgcccac cgaggcggcc ggccagggca ccgccgatgc ggcccatgcc 180
gccgcgccgg gcgaggccgc ccatggtggc gcggccaagc acgaaaccca tttcccgccc 240
ttcgacggca ccaccttcgc ctcccagttg ctgtggctcg ccgtcacctt cggcctgctt 300
tactacctca tgagcaaggt cacgctgccg cgcatcggcc gcatcctgga agagcgccac 360
gaccgcatcg ccgatgatct ggaggaagcc tccaagcatc gcgccgagag cgaggccgcc 420
cagcgggcct atgagaaggc gctgagcgag gcccgcgcga aggcccattc catcgccgcg 480
gaaacccgcg accgccttgc cgcccacgcc gacaccaacc gcaaggcgct ggagagcgag 540
ctcaccgcca agctgcaggc ggccgaggag cgcatcgcca ccaccaagag cgaagccctc 600
acccatgtgc gcggcatcgc ggtggacgcc acccaatcca tcgtctccac cctcatcggt 660
gtcgcgcccg cggcggccga cgtggaaaaa gcggtggacg gcgccctgtc ccagcacggc 720
caggcctga 729
<210> 43
<211> 242
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 43
Met Met Ile Ala Trp Lys Arg Thr Phe Ala Val Val Thr Phe Gly Ala
1 5 10 15
Ala Leu Met Ala Met Pro Val Ala Gly Val Val Ala Ala Glu Thr Ser
20 25 30
Pro Ala Pro Ala Ala Val Ala Gln Ala Asp His Ala Val Pro Thr Glu
35 40 45
Ala Ala Gly Gln Gly Thr Ala Asp Ala Ala His Ala Ala Ala Pro Gly
50 55 60
Glu Ala Ala His Gly Gly Ala Ala Lys His Glu Thr His Phe Pro Pro
65 70 75 80
Phe Asp Gly Thr Thr Phe Ala Ser Gln Leu Leu Trp Leu Ala Val Thr
85 90 95
Phe Gly Leu Leu Tyr Tyr Leu Met Ser Lys Val Thr Leu Pro Arg Ile
100 105 110
Gly Arg Ile Leu Glu Glu Arg His Asp Arg Ile Ala Asp Asp Leu Glu
115 120 125
Glu Ala Ser Lys His Arg Ala Glu Ser Glu Ala Ala Gln Arg Ala Tyr
130 135 140
Glu Lys Ala Leu Ser Glu Ala Arg Ala Lys Ala His Ser Ile Ala Ala
145 150 155 160
Glu Thr Arg Asp Arg Leu Ala Ala His Ala Asp Thr Asn Arg Lys Ala
165 170 175
Leu Glu Ser Glu Leu Thr Ala Lys Leu Gln Ala Ala Glu Glu Arg Ile
180 185 190
Ala Thr Thr Lys Ser Glu Ala Leu Thr His Val Arg Gly Ile Ala Val
195 200 205
Asp Ala Thr Gln Ser Ile Val Ser Thr Leu Ile Gly Val Ala Pro Ala
210 215 220
Ala Ala Asp Val Glu Lys Ala Val Asp Gly Ala Leu Ser Gln His Gly
225 230 235 240
Gln Ala
<210> 44
<211> 228
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 44
atggaagcgg aagctggaaa gttcatcggt gccggcctcg cctgcctcgg catgggtctc 60
gctggcgtcg gcgtcggtaa catcttcggt aacttcctct ccggcgccct gcgcaacccg 120
tccgctgccg acggccagtt cgcccgcgcc ttcatcggcg ccgccctcgc ggaaggtctc 180
ggcatcttct cgctggtcgt tgcgctcgtc ctgctgttcg tggcctga 228
<210> 45
<211> 75
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 45
Met Glu Ala Glu Ala Gly Lys Phe Ile Gly Ala Gly Leu Ala Cys Leu
1 5 10 15
Gly Met Gly Leu Ala Gly Val Gly Val Gly Asn Ile Phe Gly Asn Phe
20 25 30
Leu Ser Gly Ala Leu Arg Asn Pro Ser Ala Ala Asp Gly Gln Phe Ala
35 40 45
Arg Ala Phe Ile Gly Ala Ala Leu Ala Glu Gly Leu Gly Ile Phe Ser
50 55 60
Leu Val Val Ala Leu Val Leu Leu Phe Val Ala
65 70 75
<210> 46
<211> 753
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 46
atgaccgtcg atccgatcca ccagttcgag atcaagcgct acgtggatct gctgaacgtc 60
ggcggtgtcc agttctcctt caccaacgca acggtgttca tgattggcat cgtcctggtg 120
attttcttct tcctgacttt cgcgacacgc ggtcgcaccc ttgtgccggg ccggatgcag 180
tcggcggcgg agctgagcta cgagttcatc gccaagatgg tgcgcgacgc ggccggcagc 240
gagggaatgg tgttctttcc cttcgtcttc tcgctcttca tgttcgtgct ggtggcgaac 300
gtattggggc tcatccccta caccttcacg gtgaccgccc acctcatcgt caccgccgcc 360
ctggcggcga cggtgatcct caccgtcatc atctacggct tcgtgcggca cggcacccac 420
ttcctgcacc tgttcgtgcc gtcgggcgtg ccgggcttcc tcctgccctt cctcgtggtg 480
atcgaggtgg tgtcgttcct gtcgcggccc atcagcctct cgctgcgtct gttcgccaac 540
atgctggcgg gccacatcgc cctcaaggtg ttcgccttct tcgtcgtggg actggcctcg 600
gccggcgcga tcggctggtt cggcgccacc ctgcccttct tcatgatcgt ggcgctcacc 660
gcgctggagc tgctggtggc ggtgctgcag gcctacgtgt tcgcggtgct gacctcgatc 720
tacctcaacg acgccatcca tcccggccac tga 753
<210> 47
<211> 250
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 47
Met Thr Val Asp Pro Ile His Gln Phe Glu Ile Lys Arg Tyr Val Asp
1 5 10 15
Leu Leu Asn Val Gly Gly Val Gln Phe Ser Phe Thr Asn Ala Thr Val
20 25 30
Phe Met Ile Gly Ile Val Leu Val Ile Phe Phe Phe Leu Thr Phe Ala
35 40 45
Thr Arg Gly Arg Thr Leu Val Pro Gly Arg Met Gln Ser Ala Ala Glu
50 55 60
Leu Ser Tyr Glu Phe Ile Ala Lys Met Val Arg Asp Ala Ala Gly Ser
65 70 75 80
Glu Gly Met Val Phe Phe Pro Phe Val Phe Ser Leu Phe Met Phe Val
85 90 95
Leu Val Ala Asn Val Leu Gly Leu Ile Pro Tyr Thr Phe Thr Val Thr
100 105 110
Ala His Leu Ile Val Thr Ala Ala Leu Ala Ala Thr Val Ile Leu Thr
115 120 125
Val Ile Ile Tyr Gly Phe Val Arg His Gly Thr His Phe Leu His Leu
130 135 140
Phe Val Pro Ser Gly Val Pro Gly Phe Leu Leu Pro Phe Leu Val Val
145 150 155 160
Ile Glu Val Val Ser Phe Leu Ser Arg Pro Ile Ser Leu Ser Leu Arg
165 170 175
Leu Phe Ala Asn Met Leu Ala Gly His Ile Ala Leu Lys Val Phe Ala
180 185 190
Phe Phe Val Val Gly Leu Ala Ser Ala Gly Ala Ile Gly Trp Phe Gly
195 200 205
Ala Thr Leu Pro Phe Phe Met Ile Val Ala Leu Thr Ala Leu Glu Leu
210 215 220
Leu Val Ala Val Leu Gln Ala Tyr Val Phe Ala Val Leu Thr Ser Ile
225 230 235 240
Tyr Leu Asn Asp Ala Ile His Pro Gly His
245 250
<210> 48
<211> 390
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 48
atgtccgagc cgaatgatcc atcccgcagg gacggtgcga aggcgaaaga cgagacgcag 60
gactcccggc ccggtgaggc ggatcttgct cggcgcctcg atgcgctcgg cacctccatc 120
ggtcaggtca agtccagaag cggggagccc gcggcgacgc cgcgcaagga cacctcctcg 180
gcctccggcg cggccctggc gtttcggctg ggcgccgagt ttgtttcagg cgtgctggtg 240
ggctcgctca tcggctacgg gttggattat gcgtttgcga tttcgccctg ggggctgatc 300
gccttcacgc tgatcggctt tgccgccggc gtcctgaaca tgctgcgcgt ggcgaacagc 360
gatgccaagc gccacagcgc ggacaggtga 390
<210> 49
<211> 129
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 49
Met Ser Glu Pro Asn Asp Pro Ser Arg Arg Asp Gly Ala Lys Ala Lys
1 5 10 15
Asp Glu Thr Gln Asp Ser Arg Pro Gly Glu Ala Asp Leu Ala Arg Arg
20 25 30
Leu Asp Ala Leu Gly Thr Ser Ile Gly Gln Val Lys Ser Arg Ser Gly
35 40 45
Glu Pro Ala Ala Thr Pro Arg Lys Asp Thr Ser Ser Ala Ser Gly Ala
50 55 60
Ala Leu Ala Phe Arg Leu Gly Ala Glu Phe Val Ser Gly Val Leu Val
65 70 75 80
Gly Ser Leu Ile Gly Tyr Gly Leu Asp Tyr Ala Phe Ala Ile Ser Pro
85 90 95
Trp Gly Leu Ile Ala Phe Thr Leu Ile Gly Phe Ala Ala Gly Val Leu
100 105 110
Asn Met Leu Arg Val Ala Asn Ser Asp Ala Lys Arg His Ser Ala Asp
115 120 125
Arg
<210> 50
<211> 1929
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 50
atgagttcgc tctccgccac tattcaacag gtcttcaacg agccgggctg cgcgaagaac 60
cagaataagt ccgaggcgga gaagaagaag ggctgcacca agcagctgca acccggcgga 120
gcggccggcg gctgcgcgtt cgacggcgcg aagatcgcgc tccagccctt gaccgacgtc 180
gcccacctgg tgcacggccc catcgcctgc gaaggcaatt cctgggacaa tcgtggcgcc 240
aagtcctccg gctcgaacat ctggcgcacc ggcttcacca cggacatcaa cgaaaccgac 300
gtggtgttcg gcggcgagaa gcgtctgttc aagtccatca aggaaatcat cgagaagtac 360
gacccgccgg ccgtcttcgt ctatcagacc tgcgtccccg ccatgatcgg cgacgacatc 420
gacgcggtgt gcaaggcggc cagggagaag ttcggaaagc cggtgatccc gatcaattcc 480
cccggcttcg tggggccgaa gaatctcggc aacaagctcg ccggcgaggc gctcctcgac 540
catgtgatcg gcaccgagga gcccgattac acgacggcct acgacatcaa catcatcggc 600
gaatacaatc tctccggcga gttgtggcag gtgaagccgc tgctggacga gctgggcatc 660
cgcatcctcg cctgcatctc cggcgacggg aagtacaagg atgtggcgtc ctcccaccgc 720
gccaaggcgg cgatgatggt gtgctccaag gccatgatca acgtggcccg caagatggag 780
gagcgctacg acatcccctt cttcgaaggc tccttctacg gcatcgagga tagctccgat 840
tccctgcgcg agattgcgcg catgctcatc gagaagggcg ccgatccgga gctgatggac 900
cgcaccgagg cgctgattga gcgggaagag aagaaggcgt gggacgccat cgccgcctac 960
aagccccgct tcaaggacaa gaaggtgctg ctcatcaccg gcggcgtgaa atcctggtcg 1020
gtggtggcag cgctccagga agccggcctc gaactggtgg gcacctcggt gaagaagtcc 1080
accaaggagg acaaggagcg catcaaggaa ctgatgggcc aggacgccca catgatcgac 1140
gacatgacgc cccgcgaaat gtacaagatg ctgaaggacg ccaaggcgga catcatgctc 1200
tcgggcgggc gctcgcaatt catcgcgctc aaggccgcca tgccctggct cgacatcaac 1260
caggagcgcc accacgccta tatgggctat gtgggcatgg tgaagctggt cgaggagatc 1320
gacaaggcgc tctacaatcc cgtgtgggaa caggtgcgca agcccgcccc gtgggaaaat 1380
ccggaagaca cctggcaggc ccgtgcgctc gccgaaatgg aggcggaggc cgccgcgctc 1440
gccgccgatc cggtgcgcgc ggaagaggtg cgccggtcca agaagatctg caattgcaag 1500
agcgtcgacc tcggaaccat tgaggacgcc atcaaggctc acgcgctgac caccgtggag 1560
ggtgtgcgag agcacaccaa tgcctcggga ggctgcggag cctgcagcgg gcggatcgag 1620
gagatcttcg aggccgtggg cgttgtcgcc gccccgcctc ccgcggaggc cgccccgtct 1680
ccgcaggaga tcgcgcccga tccgctcgct gcggaggaaa agcgccgcgc caagaaggcc 1740
tgcggctgca aggaggtagc ggtcggcacc attgaggatg ccatccgcgc caagggtctg 1800
cgaaacatcg cggaggtgcg tgcggccacc gatgccaaca ccggctgcgg caattgccag 1860
gagcgggtgg agggcatcct cgaccgggtt ctcgccgagg cggcctcaga actccaggcg 1920
gcggaatag 1929
<210> 51
<211> 642
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 51
Met Ser Ser Leu Ser Ala Thr Ile Gln Gln Val Phe Asn Glu Pro Gly
1 5 10 15
Cys Ala Lys Asn Gln Asn Lys Ser Glu Ala Glu Lys Lys Lys Gly Cys
20 25 30
Thr Lys Gln Leu Gln Pro Gly Gly Ala Ala Gly Gly Cys Ala Phe Asp
35 40 45
Gly Ala Lys Ile Ala Leu Gln Pro Leu Thr Asp Val Ala His Leu Val
50 55 60
His Gly Pro Ile Ala Cys Glu Gly Asn Ser Trp Asp Asn Arg Gly Ala
65 70 75 80
Lys Ser Ser Gly Ser Asn Ile Trp Arg Thr Gly Phe Thr Thr Asp Ile
85 90 95
Asn Glu Thr Asp Val Val Phe Gly Gly Glu Lys Arg Leu Phe Lys Ser
100 105 110
Ile Lys Glu Ile Ile Glu Lys Tyr Asp Pro Pro Ala Val Phe Val Tyr
115 120 125
Gln Thr Cys Val Pro Ala Met Ile Gly Asp Asp Ile Asp Ala Val Cys
130 135 140
Lys Ala Ala Arg Glu Lys Phe Gly Lys Pro Val Ile Pro Ile Asn Ser
145 150 155 160
Pro Gly Phe Val Gly Pro Lys Asn Leu Gly Asn Lys Leu Ala Gly Glu
165 170 175
Ala Leu Leu Asp His Val Ile Gly Thr Glu Glu Pro Asp Tyr Thr Thr
180 185 190
Ala Tyr Asp Ile Asn Ile Ile Gly Glu Tyr Asn Leu Ser Gly Glu Leu
195 200 205
Trp Gln Val Lys Pro Leu Leu Asp Glu Leu Gly Ile Arg Ile Leu Ala
210 215 220
Cys Ile Ser Gly Asp Gly Lys Tyr Lys Asp Val Ala Ser Ser His Arg
225 230 235 240
Ala Lys Ala Ala Met Met Val Cys Ser Lys Ala Met Ile Asn Val Ala
245 250 255
Arg Lys Met Glu Glu Arg Tyr Asp Ile Pro Phe Phe Glu Gly Ser Phe
260 265 270
Tyr Gly Ile Glu Asp Ser Ser Asp Ser Leu Arg Glu Ile Ala Arg Met
275 280 285
Leu Ile Glu Lys Gly Ala Asp Pro Glu Leu Met Asp Arg Thr Glu Ala
290 295 300
Leu Ile Glu Arg Glu Glu Lys Lys Ala Trp Asp Ala Ile Ala Ala Tyr
305 310 315 320
Lys Pro Arg Phe Lys Asp Lys Lys Val Leu Leu Ile Thr Gly Gly Val
325 330 335
Lys Ser Trp Ser Val Val Ala Ala Leu Gln Glu Ala Gly Leu Glu Leu
340 345 350
Val Gly Thr Ser Val Lys Lys Ser Thr Lys Glu Asp Lys Glu Arg Ile
355 360 365
Lys Glu Leu Met Gly Gln Asp Ala His Met Ile Asp Asp Met Thr Pro
370 375 380
Arg Glu Met Tyr Lys Met Leu Lys Asp Ala Lys Ala Asp Ile Met Leu
385 390 395 400
Ser Gly Gly Arg Ser Gln Phe Ile Ala Leu Lys Ala Ala Met Pro Trp
405 410 415
Leu Asp Ile Asn Gln Glu Arg His His Ala Tyr Met Gly Tyr Val Gly
420 425 430
Met Val Lys Leu Val Glu Glu Ile Asp Lys Ala Leu Tyr Asn Pro Val
435 440 445
Trp Glu Gln Val Arg Lys Pro Ala Pro Trp Glu Asn Pro Glu Asp Thr
450 455 460
Trp Gln Ala Arg Ala Leu Ala Glu Met Glu Ala Glu Ala Ala Ala Leu
465 470 475 480
Ala Ala Asp Pro Val Arg Ala Glu Glu Val Arg Arg Ser Lys Lys Ile
485 490 495
Cys Asn Cys Lys Ser Val Asp Leu Gly Thr Ile Glu Asp Ala Ile Lys
500 505 510
Ala His Ala Leu Thr Thr Val Glu Gly Val Arg Glu His Thr Asn Ala
515 520 525
Ser Gly Gly Cys Gly Ala Cys Ser Gly Arg Ile Glu Glu Ile Phe Glu
530 535 540
Ala Val Gly Val Val Ala Ala Pro Pro Pro Ala Glu Ala Ala Pro Ser
545 550 555 560
Pro Gln Glu Ile Ala Pro Asp Pro Leu Ala Ala Glu Glu Lys Arg Arg
565 570 575
Ala Lys Lys Ala Cys Gly Cys Lys Glu Val Ala Val Gly Thr Ile Glu
580 585 590
Asp Ala Ile Arg Ala Lys Gly Leu Arg Asn Ile Ala Glu Val Arg Ala
595 600 605
Ala Thr Asp Ala Asn Thr Gly Cys Gly Asn Cys Gln Glu Arg Val Glu
610 615 620
Gly Ile Leu Asp Arg Val Leu Ala Glu Ala Ala Ser Glu Leu Gln Ala
625 630 635 640
Ala Glu
<210> 52
<211> 1503
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 52
atgagtgtcg cacagtccca gagcgtcgcc gagatcaagg cgcgcaacaa ggaactcatc 60
gaagaggtcc tcaaggtcta tcccgagaag accgccaagc gccgcgccaa gcacctgaac 120
gtccacgaag ccggcaagtc cgactgcggc gtgaagtcca acatcaagtc catcccgggc 180
gtgatgacca tccgcggttg cgcttatgcc ggctccaagg gtgtggtgtg gggtcccatc 240
aaggacatga tccacatctc ccacggcccg gtgggctgcg gccagtatag ctgggccgcc 300
cgccgcaact actatatcgg cacgaccggc atcgacacct tcgtgacgat gcagttcacc 360
tccgacttcc aggagaagga catcgtcttc ggcggcgaca agaagctcgc caagatcatg 420
gacgagatcc aggagctgtt cccgctgaac aacggcatca ccgttcagtc cgagtgcccc 480
atcggcctca tcggcgacga catcgaggcc gtctccaagc agaagtccaa ggagtatgag 540
ggcaagacca tcgtgccggt gcgctgcgag ggcttccgcg gcgtgtccca gtccctgggc 600
caccacatcg ccaacgacgc catccgcgat tgggtgttcg acaagatcgc gcccgacgcc 660
gagccgcgct ttgagccgac cccgtacgac gtcgccatca tcggcgacta caatatcggt 720
ggtgacgcct ggtcgtcccg tatcctcctg gaggagatgg gcctgcgcgt gatcgcccag 780
tggtccggcg acggttcgct cgctgagctg gaggccaccc cgaaggccaa gctcaacgtg 840
ctgcactgct accgctccat gaactacatc tcgcgccaca tggaagagaa gtacggtatc 900
ccgtggtgcg agtacaactt cttcggtcct tccaagatcg ccgagtccct gcgcaagatc 960
gccagctact tcgacgacaa gatcaaggaa ggcgcggagc gcgtcatcgc caagtatcag 1020
ccgctcatgg atgcggtgat cgcgaagtat cgtccccgcc tcgagggcaa gaccgtgatg 1080
ctgtacgtgg gcggcctgcg tccccgtcac gtcatcggcg cctacgagga cctgggcatg 1140
gaagtggtcg gcacgggcta cgagttcgcc cataacgacg actaccagcg caccgcccag 1200
cactacgtca aggatggcac catcatctat gacgacgtga ccggctacga gttcgagaag 1260
ttcgtcgaga agatccagcc ggacctggtc ggttcgggca tcaaggaaaa gtacgtcttc 1320
cagaagatgg gcgtgccgtt ccgccagatg cactcctggg actactcggg cccgtaccac 1380
ggctatgacg gcttcgcgat cttcgcgcgc gacatggaca tggccatcaa cagccccgtg 1440
tggaagatga cccaggctcc gtggaagagc gtccccaagc cgacgatgct cgcggctgaa 1500
tga 1503
<210> 53
<211> 500
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 53
Met Ser Val Ala Gln Ser Gln Ser Val Ala Glu Ile Lys Ala Arg Asn
1 5 10 15
Lys Glu Leu Ile Glu Glu Val Leu Lys Val Tyr Pro Glu Lys Thr Ala
20 25 30
Lys Arg Arg Ala Lys His Leu Asn Val His Glu Ala Gly Lys Ser Asp
35 40 45
Cys Gly Val Lys Ser Asn Ile Lys Ser Ile Pro Gly Val Met Thr Ile
50 55 60
Arg Gly Cys Ala Tyr Ala Gly Ser Lys Gly Val Val Trp Gly Pro Ile
65 70 75 80
Lys Asp Met Ile His Ile Ser His Gly Pro Val Gly Cys Gly Gln Tyr
85 90 95
Ser Trp Ala Ala Arg Arg Asn Tyr Tyr Ile Gly Thr Thr Gly Ile Asp
100 105 110
Thr Phe Val Thr Met Gln Phe Thr Ser Asp Phe Gln Glu Lys Asp Ile
115 120 125
Val Phe Gly Gly Asp Lys Lys Leu Ala Lys Ile Met Asp Glu Ile Gln
130 135 140
Glu Leu Phe Pro Leu Asn Asn Gly Ile Thr Val Gln Ser Glu Cys Pro
145 150 155 160
Ile Gly Leu Ile Gly Asp Asp Ile Glu Ala Val Ser Lys Gln Lys Ser
165 170 175
Lys Glu Tyr Glu Gly Lys Thr Ile Val Pro Val Arg Cys Glu Gly Phe
180 185 190
Arg Gly Val Ser Gln Ser Leu Gly His His Ile Ala Asn Asp Ala Ile
195 200 205
Arg Asp Trp Val Phe Asp Lys Ile Ala Pro Asp Ala Glu Pro Arg Phe
210 215 220
Glu Pro Thr Pro Tyr Asp Val Ala Ile Ile Gly Asp Tyr Asn Ile Gly
225 230 235 240
Gly Asp Ala Trp Ser Ser Arg Ile Leu Leu Glu Glu Met Gly Leu Arg
245 250 255
Val Ile Ala Gln Trp Ser Gly Asp Gly Ser Leu Ala Glu Leu Glu Ala
260 265 270
Thr Pro Lys Ala Lys Leu Asn Val Leu His Cys Tyr Arg Ser Met Asn
275 280 285
Tyr Ile Ser Arg His Met Glu Glu Lys Tyr Gly Ile Pro Trp Cys Glu
290 295 300
Tyr Asn Phe Phe Gly Pro Ser Lys Ile Ala Glu Ser Leu Arg Lys Ile
305 310 315 320
Ala Ser Tyr Phe Asp Asp Lys Ile Lys Glu Gly Ala Glu Arg Val Ile
325 330 335
Ala Lys Tyr Gln Pro Leu Met Asp Ala Val Ile Ala Lys Tyr Arg Pro
340 345 350
Arg Leu Glu Gly Lys Thr Val Met Leu Tyr Val Gly Gly Leu Arg Pro
355 360 365
Arg His Val Ile Gly Ala Tyr Glu Asp Leu Gly Met Glu Val Val Gly
370 375 380
Thr Gly Tyr Glu Phe Ala His Asn Asp Asp Tyr Gln Arg Thr Ala Gln
385 390 395 400
His Tyr Val Lys Asp Gly Thr Ile Ile Tyr Asp Asp Val Thr Gly Tyr
405 410 415
Glu Phe Glu Lys Phe Val Glu Lys Ile Gln Pro Asp Leu Val Gly Ser
420 425 430
Gly Ile Lys Glu Lys Tyr Val Phe Gln Lys Met Gly Val Pro Phe Arg
435 440 445
Gln Met His Ser Trp Asp Tyr Ser Gly Pro Tyr His Gly Tyr Asp Gly
450 455 460
Phe Ala Ile Phe Ala Arg Asp Met Asp Met Ala Ile Asn Ser Pro Val
465 470 475 480
Trp Lys Met Thr Gln Ala Pro Trp Lys Ser Val Pro Lys Pro Thr Met
485 490 495
Leu Ala Ala Glu
500
<210> 54
<211> 1377
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 54
atggccaccg tttccgtctc caagaaggcc tgcgcggtca accccctcaa gatgagccag 60
ccggtgggcg gcgcgctcgc cttcatgggc gtgcgcaagg ccatgccgct gctgcacggc 120
tcgcagggct gcacctcctt cggcctggtg ctgttcgtgc gccacttcaa ggaagccatc 180
cccatgcaga ccaccgccat gagcgaggtg gcgacggttc tgggcggcct tgagaatgtg 240
gagcaggcca ttctcaacat ctacaatcgc accaagccgg agatcatcgg catctgctcc 300
accggcgtca ccgagaccaa gggcgatgat gtcgacggct acatcaagct gatccgggac 360
aagtatcccc agctggccga cttcccgctg gtctatgtct ccacccccga tttcaaggac 420
gccttccagg acggttggga gaagaccgtg gcgaagatgg tggaggcgct ggtgaagccc 480
gccgccgaca agcagaagga caagacccgc gtcaacgtcc tgcccggctg ccacctcacg 540
cccggcgatc tggatgagat gcggaccatc ttcgaggatt tcgggctcac accctatttc 600
ctgccggatc tggccggctc gctggatggg catatccccg aggacttctc gcccaccacc 660
atcggcggca tcggcatcga tgagatcgcc accatgggcg aggcggccca caccatctgc 720
atcggcgcgc agatgcgccg ggcgggcgag gccatggaga agaagaccgg cattcccttc 780
aagctgttcg agcgcctgtg cggcctggag gcgaacgacg ccttcatcat gcacctgtcg 840
cagatctccg gccggccggt gccggtgaag tatcgccggc agcggggcca gctggtggat 900
gccatgctgg acggccactt ccatctgggc ggtcgcaagg tggccatggg ggcggagccg 960
gacctgctct acgacgtggg ctccttcctg cacgagatgg gcgcccacat cctttccgcg 1020
gtcaccacca cccagtcgcc ggtgctggcg cgcctgcctg ccgaggaggt gcttatcggc 1080
gacctggagg atctggagac ccaggcgaag gcgcgcggat gcgatctcct gctcacccat 1140
tcccatgggc gccaggcggc ggagcgcctc cacatcccct tctaccggat cggcattccc 1200
atgtttgacc ggctgggggc ggggcatctg ttgtcggtgg gctatcgcgg cacccgcgac 1260
ctcatcttcc atctcgccaa ccttgtgatc gccgaccacg aggaaaatca cgagccgacg 1320
cccgacacct gggccaccgg ccatggcgag catgccgccg cccccacttc ccattga 1377
<210> 55
<211> 458
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 55
Met Ala Thr Val Ser Val Ser Lys Lys Ala Cys Ala Val Asn Pro Leu
1 5 10 15
Lys Met Ser Gln Pro Val Gly Gly Ala Leu Ala Phe Met Gly Val Arg
20 25 30
Lys Ala Met Pro Leu Leu His Gly Ser Gln Gly Cys Thr Ser Phe Gly
35 40 45
Leu Val Leu Phe Val Arg His Phe Lys Glu Ala Ile Pro Met Gln Thr
50 55 60
Thr Ala Met Ser Glu Val Ala Thr Val Leu Gly Gly Leu Glu Asn Val
65 70 75 80
Glu Gln Ala Ile Leu Asn Ile Tyr Asn Arg Thr Lys Pro Glu Ile Ile
85 90 95
Gly Ile Cys Ser Thr Gly Val Thr Glu Thr Lys Gly Asp Asp Val Asp
100 105 110
Gly Tyr Ile Lys Leu Ile Arg Asp Lys Tyr Pro Gln Leu Ala Asp Phe
115 120 125
Pro Leu Val Tyr Val Ser Thr Pro Asp Phe Lys Asp Ala Phe Gln Asp
130 135 140
Gly Trp Glu Lys Thr Val Ala Lys Met Val Glu Ala Leu Val Lys Pro
145 150 155 160
Ala Ala Asp Lys Gln Lys Asp Lys Thr Arg Val Asn Val Leu Pro Gly
165 170 175
Cys His Leu Thr Pro Gly Asp Leu Asp Glu Met Arg Thr Ile Phe Glu
180 185 190
Asp Phe Gly Leu Thr Pro Tyr Phe Leu Pro Asp Leu Ala Gly Ser Leu
195 200 205
Asp Gly His Ile Pro Glu Asp Phe Ser Pro Thr Thr Ile Gly Gly Ile
210 215 220
Gly Ile Asp Glu Ile Ala Thr Met Gly Glu Ala Ala His Thr Ile Cys
225 230 235 240
Ile Gly Ala Gln Met Arg Arg Ala Gly Glu Ala Met Glu Lys Lys Thr
245 250 255
Gly Ile Pro Phe Lys Leu Phe Glu Arg Leu Cys Gly Leu Glu Ala Asn
260 265 270
Asp Ala Phe Ile Met His Leu Ser Gln Ile Ser Gly Arg Pro Val Pro
275 280 285
Val Lys Tyr Arg Arg Gln Arg Gly Gln Leu Val Asp Ala Met Leu Asp
290 295 300
Gly His Phe His Leu Gly Gly Arg Lys Val Ala Met Gly Ala Glu Pro
305 310 315 320
Asp Leu Leu Tyr Asp Val Gly Ser Phe Leu His Glu Met Gly Ala His
325 330 335
Ile Leu Ser Ala Val Thr Thr Thr Gln Ser Pro Val Leu Ala Arg Leu
340 345 350
Pro Ala Glu Glu Val Leu Ile Gly Asp Leu Glu Asp Leu Glu Thr Gln
355 360 365
Ala Lys Ala Arg Gly Cys Asp Leu Leu Leu Thr His Ser His Gly Arg
370 375 380
Gln Ala Ala Glu Arg Leu His Ile Pro Phe Tyr Arg Ile Gly Ile Pro
385 390 395 400
Met Phe Asp Arg Leu Gly Ala Gly His Leu Leu Ser Val Gly Tyr Arg
405 410 415
Gly Thr Arg Asp Leu Ile Phe His Leu Ala Asn Leu Val Ile Ala Asp
420 425 430
His Glu Glu Asn His Glu Pro Thr Pro Asp Thr Trp Ala Thr Gly His
435 440 445
Gly Glu His Ala Ala Ala Pro Thr Ser His
450 455
<210> 56
<211> 1560
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 56
atgccacaaa atgctgacaa tgtgctcgat cacttcgagc tcttccgtgg tcccgaatac 60
cagcagatgc tggccaataa gaaaaagatg ttcgagaacc cccgcgatcc ggccgaagtc 120
gagcgcgtgc gggaatgggc gaagactcct gaatacaagg agctgaactt cgcccgcgag 180
gcgctcaccg tgaatccggc caaggcttgt cagccgctgg gcgcggtgtt cgtcgccgtc 240
ggcttcgaga gcacgatccc cttcgtgcac ggctcgcagg gttgcgtcgc gtattaccgc 300
tcgcacctct cccgccactt caaggagccg tcctcctgcg tctcctcgtc catgaccgag 360
gatgcggcgg tgttcggcgg cctcaacaac atgattgacg gcctcgccaa cacctacaac 420
atgtacaagc cgaagatgat cgccgtctcc accacctgca tggcggaagt catcggcgac 480
gatctgaacg ccttcatcaa gaccgcgaag gaaaagggct cggttccggc cgaatacgac 540
gtgcccttcg cccacacccc ggcgttcgtc ggcagccatg tcaccggcta cgacaatgcg 600
ctcaagggca tcctcgagca cttctgggac ggcaaggccg gcaccgcgcc gaagctggag 660
cgcgttccca acgagaagat caacttcatc ggcggcttcg acggctacac cgtcggcaac 720
actcgcgaag tgaagcgcat cttcgaggcg ttcggcgccg attacaccat cctcgccgac 780
aattccgaag tgttcgacac cccgaccgac ggcgagttcc gcatgtatga cggcggcacg 840
accctggagg acgcggcgaa cgcggtgcac gccaaggcca ccatctccat gcaggaatac 900
tgcacggaga agaccctgcc catgatcgcc ggtcatggcc aggacgtggt cgccctcaac 960
caccccgtgg gcgtgggcgg caccgacaag ttcctcatgg agatcgcccg cctcaccggc 1020
aaggagatcc ccgaggagct gacccgcgag cgcggccgtc tcgtggacgc tatcgcggac 1080
tcttccgcgc acatccacgg caagaagttc gccatctacg gcgatccgga tctgtgcctg 1140
ggcctcgccg cgttcctgct ggagctgggc gccgagccga cccatgtgct ggccaccaac 1200
ggcaccaaga agtgggccga gaaggttcag gaactgttcg actcttcgcc gttcggcgcc 1260
aactgcaagg tctatcccgg caaggacctg tggcacatgc gctcgctcct gttcgtggag 1320
ccggtggatt tcatcatcgg caacacctac ggcaagtatc tcgagcgcga cacgggcacc 1380
ccgctgatcc gtatcggctt cccggtgttc gaccgtcacc accaccaccg ccgtccggtg 1440
tggggctatc agggcggcat gaacgtcctg atcacgatcc tcgacaagat ctttgacgag 1500
atcgaccgca acaccaacgt gccggccaag accgactact cgttcgacat cattcgttga 1560
<210> 57
<211> 519
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 57
Met Pro Gln Asn Ala Asp Asn Val Leu Asp His Phe Glu Leu Phe Arg
1 5 10 15
Gly Pro Glu Tyr Gln Gln Met Leu Ala Asn Lys Lys Lys Met Phe Glu
20 25 30
Asn Pro Arg Asp Pro Ala Glu Val Glu Arg Val Arg Glu Trp Ala Lys
35 40 45
Thr Pro Glu Tyr Lys Glu Leu Asn Phe Ala Arg Glu Ala Leu Thr Val
50 55 60
Asn Pro Ala Lys Ala Cys Gln Pro Leu Gly Ala Val Phe Val Ala Val
65 70 75 80
Gly Phe Glu Ser Thr Ile Pro Phe Val His Gly Ser Gln Gly Cys Val
85 90 95
Ala Tyr Tyr Arg Ser His Leu Ser Arg His Phe Lys Glu Pro Ser Ser
100 105 110
Cys Val Ser Ser Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Leu
115 120 125
Asn Asn Met Ile Asp Gly Leu Ala Asn Thr Tyr Asn Met Tyr Lys Pro
130 135 140
Lys Met Ile Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp
145 150 155 160
Asp Leu Asn Ala Phe Ile Lys Thr Ala Lys Glu Lys Gly Ser Val Pro
165 170 175
Ala Glu Tyr Asp Val Pro Phe Ala His Thr Pro Ala Phe Val Gly Ser
180 185 190
His Val Thr Gly Tyr Asp Asn Ala Leu Lys Gly Ile Leu Glu His Phe
195 200 205
Trp Asp Gly Lys Ala Gly Thr Ala Pro Lys Leu Glu Arg Val Pro Asn
210 215 220
Glu Lys Ile Asn Phe Ile Gly Gly Phe Asp Gly Tyr Thr Val Gly Asn
225 230 235 240
Thr Arg Glu Val Lys Arg Ile Phe Glu Ala Phe Gly Ala Asp Tyr Thr
245 250 255
Ile Leu Ala Asp Asn Ser Glu Val Phe Asp Thr Pro Thr Asp Gly Glu
260 265 270
Phe Arg Met Tyr Asp Gly Gly Thr Thr Leu Glu Asp Ala Ala Asn Ala
275 280 285
Val His Ala Lys Ala Thr Ile Ser Met Gln Glu Tyr Cys Thr Glu Lys
290 295 300
Thr Leu Pro Met Ile Ala Gly His Gly Gln Asp Val Val Ala Leu Asn
305 310 315 320
His Pro Val Gly Val Gly Gly Thr Asp Lys Phe Leu Met Glu Ile Ala
325 330 335
Arg Leu Thr Gly Lys Glu Ile Pro Glu Glu Leu Thr Arg Glu Arg Gly
340 345 350
Arg Leu Val Asp Ala Ile Ala Asp Ser Ser Ala His Ile His Gly Lys
355 360 365
Lys Phe Ala Ile Tyr Gly Asp Pro Asp Leu Cys Leu Gly Leu Ala Ala
370 375 380
Phe Leu Leu Glu Leu Gly Ala Glu Pro Thr His Val Leu Ala Thr Asn
385 390 395 400
Gly Thr Lys Lys Trp Ala Glu Lys Val Gln Glu Leu Phe Asp Ser Ser
405 410 415
Pro Phe Gly Ala Asn Cys Lys Val Tyr Pro Gly Lys Asp Leu Trp His
420 425 430
Met Arg Ser Leu Leu Phe Val Glu Pro Val Asp Phe Ile Ile Gly Asn
435 440 445
Thr Tyr Gly Lys Tyr Leu Glu Arg Asp Thr Gly Thr Pro Leu Ile Arg
450 455 460
Ile Gly Phe Pro Val Phe Asp Arg His His His His Arg Arg Pro Val
465 470 475 480
Trp Gly Tyr Gln Gly Gly Met Asn Val Leu Ile Thr Ile Leu Asp Lys
485 490 495
Ile Phe Asp Glu Ile Asp Arg Asn Thr Asn Val Pro Ala Lys Thr Asp
500 505 510
Tyr Ser Phe Asp Ile Ile Arg
515
<210> 58
<211> 621
<212> DNA
<213> 未知
<220>
<223> 新型菌株
<400> 58
gtggagtccg gtggtcctga gccgggcgtg ggctgcgccg gccgcggcgt gatcacctcc 60
atcaacttcc tggaggagaa cggcgcctac gaggacatcg actatgtgtc ctacgacgtg 120
ctgggcgacg tggtgtgcgg cggcttcgcc atgcccatcc gcgagaacaa ggcgcaggaa 180
atctacatcg tgatgtccgg cgagatgatg gccatgtatg cggccaacaa catctccaag 240
ggcatcctga agtatgccaa ttccggcggc gtgcgcctgg gcgggctggt ctgcaacgag 300
cgccagaccg acaaggagct ggagctggcg gaggctctgg cgaagaagct cggcaccgag 360
ctgatctact tcgtgccgcg cgacaacatc gtgcagcatg ccgagctgcg ccgcatgaca 420
gtgatcgagt atgcgcccga ttccgcccag gcccagcact accggaacct ggccgagaag 480
gtgcacgcca acaagggcaa cggcatcatc ccgaccccga tcaccatgga cgagctggaa 540
gacatgctca tggagcacgg catcatgaag gccgtggacg agagccagat cggcaagacc 600
gccgccgagc tcgccgtctg a 621
<210> 59
<211> 206
<212> PRT
<213> 未知
<220>
<223> 新型菌株
<400> 59
Met Glu Ser Gly Gly Pro Glu Pro Gly Val Gly Cys Ala Gly Arg Gly
1 5 10 15
Val Ile Thr Ser Ile Asn Phe Leu Glu Glu Asn Gly Ala Tyr Glu Asp
20 25 30
Ile Asp Tyr Val Ser Tyr Asp Val Leu Gly Asp Val Val Cys Gly Gly
35 40 45
Phe Ala Met Pro Ile Arg Glu Asn Lys Ala Gln Glu Ile Tyr Ile Val
50 55 60
Met Ser Gly Glu Met Met Ala Met Tyr Ala Ala Asn Asn Ile Ser Lys
65 70 75 80
Gly Ile Leu Lys Tyr Ala Asn Ser Gly Gly Val Arg Leu Gly Gly Leu
85 90 95
Val Cys Asn Glu Arg Gln Thr Asp Lys Glu Leu Glu Leu Ala Glu Ala
100 105 110
Leu Ala Lys Lys Leu Gly Thr Glu Leu Ile Tyr Phe Val Pro Arg Asp
115 120 125
Asn Ile Val Gln His Ala Glu Leu Arg Arg Met Thr Val Ile Glu Tyr
130 135 140
Ala Pro Asp Ser Ala Gln Ala Gln His Tyr Arg Asn Leu Ala Glu Lys
145 150 155 160
Val His Ala Asn Lys Gly Asn Gly Ile Ile Pro Thr Pro Ile Thr Met
165 170 175
Asp Glu Leu Glu Asp Met Leu Met Glu His Gly Ile Met Lys Ala Val
180 185 190
Asp Glu Ser Gln Ile Gly Lys Thr Ala Ala Glu Leu Ala Val
195 200 205
Claims (29)
1.一种分离的细菌菌株,所述细菌菌株于2019年6月11日保藏于VTT培养物保藏中心,保藏编号为VTT E-193585。
2.一种培养物,其包含根据权利要求1所述的细菌菌株。
3.一种用于生产生物质的方法,所述方法包括培养根据权利要求1所述的细菌菌株。
4.根据权利要求3所述的方法,其包括在使用无机碳源和作为能源的氢的连续培养中培养所述细菌菌株,其中所述无机碳源包括二氧化碳。
5.根据权利要求4所述的方法,其中所述连续培养的培养物中的溶解氧维持在5%和10%之间。
6.根据权利要求4所述的方法,其中铵、尿素、硝酸盐和/或氮气用作氮源。
7.根据权利要求4所述的方法,其中所述连续培养的培养基包含矿物质,其中所述矿物质包含小于1g/L的氯盐。
8.根据权利要求7所述的方法,其中所述矿物质包含小于0.25g/L的氯盐。
9.根据权利要求7所述的方法,其中所述矿物质包含小于0.1g/L的氯盐。
10.根据权利要求7所述的方法,其中所述矿物质不含氯盐。
11.根据权利要求4所述的方法,其中所述连续培养的培养基不含维生素。
12.根据权利要求4所述的方法,其中所述连续培养的培养物中的pH维持在5.5和8.0之间。
13.根据权利要求4所述的方法,其中所述连续培养的培养物中的pH维持在6.5和7.0之间。
14.根据权利要求4所述的方法,其中所述连续培养的培养物中的pH维持在6.8。
15.根据权利要求4所述的方法,其中所述连续培养的培养物在25℃和40℃之间的温度下生长。
16.根据权利要求4所述的方法,其中所述连续培养的培养物在28℃和32℃之间的温度下生长。
17.根据权利要求4所述的方法,其中所述连续培养的培养物在30℃的温度下生长。
18.根据权利要求4所述的方法,其中所述细菌菌株具有0.04-0.12h-1的生长速率。
19.根据权利要求4所述的方法,其中所述细菌菌株包含SEQ ID NO:1中所示的16S核糖体RNA。
20.根据权利要求4所述的方法,其中所述细菌菌株包含:
i)编码核酮糖-1,5-二磷酸羧化酶/加氧酶(rubisco)大链的基因,其序列如SEQ IDNO:3所示,和/或
ii)编码核酮糖-1,5-二磷酸羧化酶/加氧酶(rubisco)小链的基因,其序列如SEQ IDNO:5所示,和/或
iii)编码NAD+还原氢化酶HoxS亚基α的基因,其序列如SEQ ID NO:7所示,和/或
iv)编码NAD+还原氢化酶HoxS亚基β的基因,其序列如SEQ ID NO:9所示,和/或
v)编码NAD+还原氢化酶HoxS亚基γ的基因,其序列如SEQ ID NO:11所示,和/或
vi)编码NAD+还原氢化酶HoxS亚基δ的基因,其序列如SEQ ID NO:13所示,和/或
vii)编码NiFeSe氢化酶大亚基的基因,其序列如SEQ ID NO:15所示,和/或
viii)编码NiFeSe氢化酶小亚基的基因,其序列如SEQ ID NO:17所示,和/或
ix)编码ATP合酶γ链atpG_1的基因,其序列如SEQ ID NO:19所示,和/或
x)编码ATP合酶亚基αatpA_1的基因,其序列如SEQ ID NO:21所示,和/或
xi)编码ATP合酶亚基b atpF_1的基因,其序列如SEQ ID NO:23所示,和/或
xii)编码ATP合酶亚基c,钠离子特异性atpE_1的基因,其序列如SEQ ID NO:25所示,和/或
xiii)编码ATP合酶亚基a atpB_1的基因,其序列如SEQ ID NO:27所示,和/或
xiv)编码ATP合酶ε链atpC_1的基因,其序列如SEQ ID NO:29所示,和/或
xv)编码ATP合酶亚基βatpD_1的基因,其序列如SEQ ID NO:31所示,和/或
xvi)编码ATP合酶亚基βatpD_2的基因,其序列如SEQ ID NO:33所示,和/或
xvii)编码ATP合酶γ链atpG_2的基因,其序列如SEQ ID NO:35所示,和/或
xviii)编码ATP合酶亚基αatpA_2的基因,其序列如SEQ ID NO:37所示,和/或
xix)编码ATP合酶亚基δatpH的基因,其序列如SEQ ID NO:39所示,和/或
xx)编码ATP合酶亚基b atpF_2的基因,其序列如SEQ ID NO:41所示,和/或
xxi)编码ATP合酶亚基b'atpG_3的基因,其序列如SEQ ID NO:43所示,和/或
xxii)编码ATP合酶亚基c atpE_2的基因,其序列如SEQ ID NO:45所示,和/或
xxiii)编码ATP合酶亚基a atpB_2的基因,其序列如SEQ ID NO:47所示,和/或
xiv)编码ATP合酶蛋白I atpI的基因,其序列如SEQ ID NO:49所示,和/或
xv)编码固氮酶钼铁蛋白α链nifD_1的基因,其序列如SEQ ID NO:51所示,和/或
xvi)编码固氮酶钼铁蛋白α链nifD_2的基因,其序列如SEQ ID NO:53所示,和/或
xvii)编码固氮酶钼铁蛋白β链nifK_1的基因,其序列如SEQ ID NO:55所示,和/或
xviii)编码固氮酶钼铁蛋白β链nifK_2的基因,其序列如SEQ ID NO:57所示,和/或
xxix)编码固氮酶铁蛋白nifH的基因,其序列如SEQ ID NO:59所示。
21.根据权利要求20所述的方法,其中所述细菌菌株包含:
·iii)、iv)、v)和vi)中描述的基因,
·vii)和viii)中描述的基因,或
·iii)、iv)、v)、vi)、vii)和viii)中描述的基因。
22.根据权利要求4所述的方法,其包括收获在培养期间产生的生物质的进一步步骤。
23.根据权利要求22所述的方法,还包括使所述生物质干燥的进一步步骤。
24.根据权利要求22所述的方法,其包括从所述生物质生产食物或饲料产物的进一步步骤。
25.一种用于生产蛋白质的方法,其包括执行根据权利要求22所述的方法和从所述生物质中分离蛋白质的进一步步骤,其中所述方法得到蛋白质级分和包含非蛋白质组分的级分。
26.根据权利要求25所述的方法,其包括从所述蛋白质级分或所述包含非蛋白质组分的级分生产食物或饲料产物的进一步步骤。
27.一种生物质,其获得自根据权利要求3至23中任一项所述的方法或能由根据权利要求3至23中任一项所述的方法获得。
28.一种蛋白质或非蛋白质组分,其获得自根据权利要求25所述的方法或能由根据权利要求25所述的方法获得。
29.一种食物或饲料产物,其获得自根据权利要求24或26所述的方法或能由根据权利要求24或26所述的方法获得。
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JPS6258989A (ja) * | 1985-09-07 | 1987-03-14 | Agency Of Ind Science & Technol | 微生物菌体の製造法 |
WO2013148348A1 (en) * | 2012-03-28 | 2013-10-03 | Kiverdi, Inc. | Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same |
WO2015027209A2 (en) * | 2013-08-22 | 2015-02-26 | Kiverdi, Inc. | Microorganisms for biosynthesis of limonene on gaseous substrates |
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CN109154006A (zh) * | 2016-03-19 | 2019-01-04 | 基沃德股份有限公司 | 用于从c1底物生产蛋白质,食品和有用副产品的微生物和人工生态系统 |
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JPS6258989A (ja) * | 1985-09-07 | 1987-03-14 | Agency Of Ind Science & Technol | 微生物菌体の製造法 |
WO2013148348A1 (en) * | 2012-03-28 | 2013-10-03 | Kiverdi, Inc. | Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same |
WO2015027209A2 (en) * | 2013-08-22 | 2015-02-26 | Kiverdi, Inc. | Microorganisms for biosynthesis of limonene on gaseous substrates |
CN109154006A (zh) * | 2016-03-19 | 2019-01-04 | 基沃德股份有限公司 | 用于从c1底物生产蛋白质,食品和有用副产品的微生物和人工生态系统 |
WO2018144965A1 (en) * | 2017-02-03 | 2018-08-09 | Kiverdi, Inc. | Microbial conversion of co2 and other c1 substrates to vegan nutrients, fertilizers, biostimulants, and systems for accelerated soil carbon sequestration |
Non-Patent Citations (11)
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HUE062442T2 (hu) | 2023-11-28 |
US20240093141A1 (en) | 2024-03-21 |
JP2024056855A (ja) | 2024-04-23 |
WO2021084159A1 (en) | 2021-05-06 |
AU2020375167A1 (en) | 2022-04-14 |
EP3816293B1 (en) | 2023-07-19 |
PL3816293T3 (pl) | 2023-09-18 |
ZA202203922B (en) | 2023-07-26 |
EP3816293C0 (en) | 2023-07-19 |
AU2020375167B2 (en) | 2023-11-02 |
EP4073255A1 (en) | 2022-10-19 |
HRP20230881T1 (hr) | 2023-11-10 |
KR20220053683A (ko) | 2022-04-29 |
RS64555B1 (sr) | 2023-10-31 |
MX2022003927A (es) | 2022-04-25 |
CL2022000747A1 (es) | 2022-11-11 |
EP3816293A1 (en) | 2021-05-05 |
IL292282A (en) | 2022-06-01 |
CA3153196A1 (en) | 2021-05-06 |
JP7514918B2 (ja) | 2024-07-11 |
PE20220605A1 (es) | 2022-04-25 |
ES2958737T3 (es) | 2024-02-14 |
CO2022003736A2 (es) | 2022-05-20 |
CN114599779A (zh) | 2022-06-07 |
JP2023500430A (ja) | 2023-01-06 |
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