CN114502565A - 制造二环亚磷酰胺的方法 - Google Patents

制造二环亚磷酰胺的方法 Download PDF

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Publication number
CN114502565A
CN114502565A CN202080072429.5A CN202080072429A CN114502565A CN 114502565 A CN114502565 A CN 114502565A CN 202080072429 A CN202080072429 A CN 202080072429A CN 114502565 A CN114502565 A CN 114502565A
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formula
group
compound
compound represented
solution
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Chinese (zh)
Inventor
道田诚
鹈饲和利
阿部祐三
松本萌
山冈诚
仓桥慧
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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Publication of CN114502565A publication Critical patent/CN114502565A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/10—Anhydrosugars, e.g. epoxides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN202080072429.5A 2019-10-18 2020-10-16 制造二环亚磷酰胺的方法 Pending CN114502565A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-191053 2019-10-18
JP2019191053 2019-10-18
PCT/JP2020/039050 WO2021075538A1 (ja) 2019-10-18 2020-10-16 二環性ホスホロアミダイトの製造方法

Publications (1)

Publication Number Publication Date
CN114502565A true CN114502565A (zh) 2022-05-13

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CN202080072429.5A Pending CN114502565A (zh) 2019-10-18 2020-10-16 制造二环亚磷酰胺的方法

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Country Link
US (1) US20230348522A1 (https=)
EP (1) EP4047005A4 (https=)
JP (1) JP7641905B2 (https=)
KR (1) KR20220083707A (https=)
CN (1) CN114502565A (https=)
BR (1) BR112022007437A2 (https=)
CA (1) CA3155028A1 (https=)
IL (1) IL292286A (https=)
TW (1) TW202128704A (https=)
WO (1) WO2021075538A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116178196A (zh) * 2021-11-26 2023-05-30 中国科学院大连化学物理研究所 一种烯烃和胺类多相催化制酰胺类化合物的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021049504A1 (ja) * 2019-09-10 2021-03-18 第一三共株式会社 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1279687A (zh) * 1997-09-12 2001-01-10 埃克西康有限公司 寡核苷酸类似物
CN1347418A (zh) * 1999-02-12 2002-05-01 三共株式会社 新型核苷及低聚核苷酸类似物
US6525191B1 (en) * 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
US20060166908A1 (en) * 2002-02-13 2006-07-27 Takeshi Imanishi Nucloeside analogues and oligonucleotide derivative comprising nucleotide analogue thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US62519A (en) * 1867-03-05 Improved peat machine
JPH0787982A (ja) 1993-01-29 1995-04-04 Sankyo Co Ltd 修飾オリゴデオキシリボヌクレオチド
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6096881A (en) 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
JP2001247596A (ja) * 2000-03-07 2001-09-11 Univ Nagoya オリゴヌクレオチド糖コンジュゲート、オリゴヌクレオチド糖コンジュゲートの製造方法
JP2002322192A (ja) * 2000-08-10 2002-11-08 Sankyo Co Ltd ２’−ｏ，４’−ｃ−架橋ヌクレオシドトリリン酸体
AU2002328792A1 (en) * 2001-07-12 2003-01-29 Santaris Pharma A/S Method for preparation of lna phosphoramidites
JP4777777B2 (ja) * 2002-11-25 2011-09-21 雅文 松尾 ｍＲＮＡ前駆体のスプライシングを修飾するＥＮＡ核酸医薬
WO2005028494A1 (ja) * 2003-09-02 2005-03-31 Takeshi Wada ５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法
RU2648950C2 (ru) * 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
WO2013191129A1 (ja) 2012-06-18 2013-12-27 第一三共株式会社 ヌクレオシド類縁体の製造中間体及びその製造方法
WO2018049535A1 (en) * 2016-09-16 2018-03-22 Lcb Pharma Inc. Nucleoside analogues and methods of use thereof
CN111511915A (zh) 2018-03-09 2020-08-07 第一三共株式会社 糖原病Ia型治疗药
WO2019224172A1 (en) * 2018-05-25 2019-11-28 Roche Innovation Center Copenhagen A/S Novel process for making allofuranose from glucofuranose

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1279687A (zh) * 1997-09-12 2001-01-10 埃克西康有限公司 寡核苷酸类似物
CN1347418A (zh) * 1999-02-12 2002-05-01 三共株式会社 新型核苷及低聚核苷酸类似物
US6525191B1 (en) * 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
US20060166908A1 (en) * 2002-02-13 2006-07-27 Takeshi Imanishi Nucloeside analogues and oligonucleotide derivative comprising nucleotide analogue thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116178196A (zh) * 2021-11-26 2023-05-30 中国科学院大连化学物理研究所 一种烯烃和胺类多相催化制酰胺类化合物的方法
CN116178196B (zh) * 2021-11-26 2025-07-25 中国科学院大连化学物理研究所 一种烯烃和胺类多相催化制酰胺类化合物的方法

Also Published As

Publication number Publication date
IL292286A (en) 2022-06-01
TW202128704A (zh) 2021-08-01
EP4047005A4 (en) 2024-03-06
CA3155028A1 (en) 2021-04-22
KR20220083707A (ko) 2022-06-20
BR112022007437A2 (pt) 2022-10-11
JP7641905B2 (ja) 2025-03-07
WO2021075538A1 (ja) 2021-04-22
EP4047005A1 (en) 2022-08-24
JPWO2021075538A1 (https=) 2021-04-22
US20230348522A1 (en) 2023-11-02

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Application publication date: 20220513