BR112022007437A2 - Método para a produção de fosforamidita bicíclica - Google Patents
Método para a produção de fosforamidita bicíclicaInfo
- Publication number
- BR112022007437A2 BR112022007437A2 BR112022007437A BR112022007437A BR112022007437A2 BR 112022007437 A2 BR112022007437 A2 BR 112022007437A2 BR 112022007437 A BR112022007437 A BR 112022007437A BR 112022007437 A BR112022007437 A BR 112022007437A BR 112022007437 A2 BR112022007437 A2 BR 112022007437A2
- Authority
- BR
- Brazil
- Prior art keywords
- phosphoramidite
- bicyclic
- production
- producing
- ena monomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/10—Anhydrosugars, e.g. epoxides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019191053 | 2019-10-18 | ||
| PCT/JP2020/039050 WO2021075538A1 (ja) | 2019-10-18 | 2020-10-16 | 二環性ホスホロアミダイトの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022007437A2 true BR112022007437A2 (pt) | 2022-10-11 |
Family
ID=75538087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022007437A BR112022007437A2 (pt) | 2019-10-18 | 2020-10-16 | Método para a produção de fosforamidita bicíclica |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230348522A1 (https=) |
| EP (1) | EP4047005A4 (https=) |
| JP (1) | JP7641905B2 (https=) |
| KR (1) | KR20220083707A (https=) |
| CN (1) | CN114502565A (https=) |
| BR (1) | BR112022007437A2 (https=) |
| CA (1) | CA3155028A1 (https=) |
| IL (1) | IL292286A (https=) |
| TW (1) | TW202128704A (https=) |
| WO (1) | WO2021075538A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL291251B1 (en) * | 2019-09-10 | 2026-02-01 | Daiichi Sankyo Co Ltd | Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production |
| CN116178196B (zh) * | 2021-11-26 | 2025-07-25 | 中国科学院大连化学物理研究所 | 一种烯烃和胺类多相催化制酰胺类化合物的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US62519A (en) * | 1867-03-05 | Improved peat machine | ||
| JPH0787982A (ja) | 1993-01-29 | 1995-04-04 | Sankyo Co Ltd | 修飾オリゴデオキシリボヌクレオチド |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6096881A (en) | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
| JP4236812B2 (ja) | 1997-09-12 | 2009-03-11 | エクシコン エ／エス | オリゴヌクレオチド類似体 |
| ES2234563T5 (es) * | 1999-02-12 | 2018-01-17 | Daiichi Sankyo Company, Limited | Nuevos análogos de nucleósidos y oligonucleótidos |
| US6525191B1 (en) * | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| JP2001247596A (ja) * | 2000-03-07 | 2001-09-11 | Univ Nagoya | オリゴヌクレオチド糖コンジュゲート、オリゴヌクレオチド糖コンジュゲートの製造方法 |
| JP2002322192A (ja) * | 2000-08-10 | 2002-11-08 | Sankyo Co Ltd | ２’−ｏ，４’−ｃ−架橋ヌクレオシドトリリン酸体 |
| ATE287413T1 (de) * | 2001-07-12 | 2005-02-15 | Santaris Pharma As | Verfahren zur herstellung des lna phosphoramidite |
| EP1481983A4 (en) * | 2002-02-13 | 2008-04-02 | Takeshi Imanishi | NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF |
| EP2392660A3 (en) * | 2002-11-25 | 2012-03-28 | Masafumi Matsuo | ENA Nucleic Acid Drugs Modifying Splicing in mRNA Precursor |
| JP4616175B2 (ja) * | 2003-09-02 | 2011-01-19 | 株式会社キラルジェン | ５’−ホスフィチル化モノマーおよびｈ−ホスホネートオリゴヌクレオチド誘導体の製造方法 |
| DE19216461T1 (de) * | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| EP2862868B1 (en) | 2012-06-18 | 2020-04-08 | Daiichi Sankyo Company, Limited | Intermediate for production of nucleoside analogue, and method for producing same |
| WO2018049534A1 (en) * | 2016-09-16 | 2018-03-22 | Lcb Pharma Inc. | Nucleoside and nucleotide analogues bearing a quaternary all-carbon stereogenic center at the 2' position and methods of use as a cardioprotective agent |
| KR102398295B1 (ko) * | 2018-03-09 | 2022-05-17 | 다이이찌 산쿄 가부시키가이샤 | 당원병 Ia형 치료약 |
| WO2019224172A1 (en) * | 2018-05-25 | 2019-11-28 | Roche Innovation Center Copenhagen A/S | Novel process for making allofuranose from glucofuranose |
-
2020
- 2020-10-16 IL IL292286A patent/IL292286A/en unknown
- 2020-10-16 CA CA3155028A patent/CA3155028A1/en active Pending
- 2020-10-16 CN CN202080072429.5A patent/CN114502565A/zh active Pending
- 2020-10-16 TW TW109135908A patent/TW202128704A/zh unknown
- 2020-10-16 EP EP20877640.1A patent/EP4047005A4/en active Pending
- 2020-10-16 US US17/769,483 patent/US20230348522A1/en active Pending
- 2020-10-16 WO PCT/JP2020/039050 patent/WO2021075538A1/ja not_active Ceased
- 2020-10-16 JP JP2021552461A patent/JP7641905B2/ja active Active
- 2020-10-16 BR BR112022007437A patent/BR112022007437A2/pt not_active Application Discontinuation
- 2020-10-16 KR KR1020227012762A patent/KR20220083707A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2021075538A1 (https=) | 2021-04-22 |
| TW202128704A (zh) | 2021-08-01 |
| EP4047005A4 (en) | 2024-03-06 |
| IL292286A (en) | 2022-06-01 |
| CN114502565A (zh) | 2022-05-13 |
| CA3155028A1 (en) | 2021-04-22 |
| EP4047005A1 (en) | 2022-08-24 |
| JP7641905B2 (ja) | 2025-03-07 |
| KR20220083707A (ko) | 2022-06-20 |
| US20230348522A1 (en) | 2023-11-02 |
| WO2021075538A1 (ja) | 2021-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |