CN114466657B - 包括蛋白酶激活治疗剂的组合物和方法 - Google Patents

包括蛋白酶激活治疗剂的组合物和方法 Download PDF

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CN114466657B
CN114466657B CN202080067433.2A CN202080067433A CN114466657B CN 114466657 B CN114466657 B CN 114466657B CN 202080067433 A CN202080067433 A CN 202080067433A CN 114466657 B CN114466657 B CN 114466657B
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polypeptide
tumor
use according
antibody
seq
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CN114466657A (zh
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杰弗里·哈贝尔
石原纯
胡安·门多萨
阿斯兰·曼苏罗夫
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University of Chicago
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    • C07K14/52Cytokines; Lymphokines; Interferons
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CN202080067433.2A 2019-07-25 2020-07-24 包括蛋白酶激活治疗剂的组合物和方法 Active CN114466657B (zh)

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US201962878574P 2019-07-25 2019-07-25
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PCT/US2020/070308 WO2021016640A1 (en) 2019-07-25 2020-07-24 Compositions and methods comprising protease-activated therapeutic agents

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US20240228586A1 (en) * 2021-05-07 2024-07-11 The University Of Chicago Compositions and methods comprising protease-activated therapeutic agents
CN117957258A (zh) 2021-07-19 2024-04-30 中外制药株式会社 利用融合多肽的蛋白酶介导的靶向特异性细胞因子递送
AU2022314734A1 (en) 2021-07-19 2024-02-08 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
CN118647629A (zh) * 2021-09-28 2024-09-13 苏州格治生物科技有限公司 含有TNF-α的免疫缀合物及其相关方法和组合物
KR102609822B1 (ko) * 2021-10-05 2023-12-06 (주)케어젠 항염증 활성을 갖는 펩타이드와 이의 용도
CA3234552A1 (en) 2021-10-20 2023-04-27 Synthekine, Inc. Heterodimeric fc cytokines and uses thereof
CN113995855A (zh) * 2021-11-10 2022-02-01 中国药科大学 一种抗纤维化纳米载体和纳米制剂及其制备方法
CN114272390B (zh) * 2021-12-29 2022-09-02 中山大学附属第一医院 一种微环境靶向联合细胞靶向肿瘤抑制载体及其制备方法和应用
CN120112547A (zh) 2022-11-16 2025-06-06 瑞泽恩制药公司 包含膜结合il-12和蛋白酶可裂解接头的嵌合蛋白
CN119060196A (zh) * 2023-05-31 2024-12-03 郑州大学 一种金属蛋白酶激活型car-t结构的制备及其应用

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