JP7682150B2 - プロテアーゼ活性化治療剤を含む組成物および方法 - Google Patents

プロテアーゼ活性化治療剤を含む組成物および方法 Download PDF

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JP7682150B2
JP7682150B2 JP2022504582A JP2022504582A JP7682150B2 JP 7682150 B2 JP7682150 B2 JP 7682150B2 JP 2022504582 A JP2022504582 A JP 2022504582A JP 2022504582 A JP2022504582 A JP 2022504582A JP 7682150 B2 JP7682150 B2 JP 7682150B2
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polypeptide
antibody
tumor
linker
cancer
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JP2022542886A5 (https=
JP2022542886A (ja
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ジェフリー ハベル
純 石原
ジュアン メンドザ
アスラン マンスロヴ
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University of Chicago
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2022504582A 2019-07-25 2020-07-24 プロテアーゼ活性化治療剤を含む組成物および方法 Active JP7682150B2 (ja)

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US201962878574P 2019-07-25 2019-07-25
US62/878,574 2019-07-25
PCT/US2020/070308 WO2021016640A1 (en) 2019-07-25 2020-07-24 Compositions and methods comprising protease-activated therapeutic agents

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WO2021207669A1 (en) 2020-04-10 2021-10-14 Cytomx Therapeutics, Inc. Activatable cytokine constructs and related compositions and methods
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WO2022115865A2 (en) 2020-11-25 2022-06-02 Xilio Development, Inc. Tumor-specific cleavable linkers
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US20240228586A1 (en) * 2021-05-07 2024-07-11 The University Of Chicago Compositions and methods comprising protease-activated therapeutic agents
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AU2022314734A1 (en) 2021-07-19 2024-02-08 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
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KR102609822B1 (ko) * 2021-10-05 2023-12-06 (주)케어젠 항염증 활성을 갖는 펩타이드와 이의 용도
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CN113995855A (zh) * 2021-11-10 2022-02-01 中国药科大学 一种抗纤维化纳米载体和纳米制剂及其制备方法
CN114272390B (zh) * 2021-12-29 2022-09-02 中山大学附属第一医院 一种微环境靶向联合细胞靶向肿瘤抑制载体及其制备方法和应用
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