CN114376928A - Oil-control acne-removing skin-care composition and preparation method thereof - Google Patents
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Abstract
The invention relates to A61K8, in particular to an oil-control acne-removal skin-care composition and a preparation method thereof. The raw materials of the oil-controlling acne-removing skin-care composition comprise glycine substances, an anti-oil and fat oxidizing agent and azelaic acid derivatives. The oil-control acne-removing composition provided by the invention is applied to a skin care product, and can effectively condition the skin and maintain the balance of skin tissue barriers. By inhibiting 5 alpha-reductase, the activity of sebaceous glands is reduced, so that excessive secretion of sebum is reduced, and acne is removed from the root. The invention can be widely applied to face cleaning, skin care and body beautifying products, and effectively improves the skin condition.
Description
Technical Field
The invention relates to A61K8, in particular to an oil-control acne-removal skin-care composition and a preparation method thereof.
Background
Whether dry, oily, neutral or mixed hides, are often subject to oil development. The excessive secretion of skin oil causes pores to become a bacterial hotbed, thereby inducing a series of problems of mouth closure, acne and the like, so people need to use corresponding oil-control skin care products to improve the skin problem.
The patent number CN113456534A provides an oil-controlling acne-removing mixture with multiple skin-care effects and a preparation method thereof, and by adding a sterilization acne-removing component and multiple penetration-promoting components, acne can be quickly inhibited, skin can be conditioned, and secretion of grease can be reduced, so that a certain effect of preventing recurrence of acne can be achieved.
However, some natural plant extracts in these oil control skin care products have slightly changed properties with the increase of the placing time and the change of the external environment, so that the efficacy is greatly influenced.
Disclosure of Invention
In order to solve the above problems, the present invention provides, in a first aspect, an oil-controlling, acne-removing skin care composition, which comprises glycine, an anti-sebum oxidant and an azelaic acid derivative as raw materials.
In a preferred embodiment of the present invention, the glycine-containing substance is caprylyl glycine and/or lauroyl glycine.
In a preferred embodiment of the present invention, the anti-grease-oxidizing agent is one or more selected from cinnamomum zeylanicum bark extract, nordihydroguaiaretic acid, and gallnut extract.
As a preferable technical scheme of the invention, the azelaic acid derivative is selected from one or more of azelaic acid cyclodextrin inclusion compound, potassium azelate diglycine and potassium azelate amino acid salt.
Potassium azelaic acid diglycine
Potassium azelate diglycinate is an azelaic acid derivative, has water solubility and small using amount, has good effect of regulating oil secretion, and has remarkable whitening effect. Research shows that the polypeptide can play a biological effect on the basis of ensuring safety. It has good inhibitory effect on seborrheic and acne problems of skin. When the whitening cream is applied to the skin of a human body, the effective activity of tyrosinase can be competitively inhibited, the whitening effect is achieved, the skin moisturizing capability can be improved, and the skin tissue elasticity can be improved.
As a preferable technical scheme, the raw materials of the oil-controlling acne-removing skin-care composition comprise deionized water, propylene glycol, sodium hyaluronate and disodium EDTA.
As a preferable technical scheme, the raw materials of the oil-controlling acne-removing skin-care composition comprise butanediol, p-hydroxyacetophenone and 1, 2-hexanediol.
As a preferred technical scheme, the raw materials of the oil-controlling acne-removing skin-care composition comprise deionized water, butanediol, a scutellaria baicalensis root extract, a sophora flavescens root extract and a glycyrrhiza inflata root extract.
The raw materials of the oil-control acne-removing skin-care composition in the preferable technical scheme of the invention also comprise hexanediol, sarcosine, butanediol, phenoxyethanol, ethylhexyl glycerol and methyl hydroxybenzoate.
As a preferable technical scheme of the invention, the raw materials of the oil-controlling acne-removing skin-care composition comprise essence and PEG-40 hydrogenated castor oil, wherein the weight ratio of the essence to the PEG-40 hydrogenated castor oil is (0.001-0.2): (0.004-0.8).
The applicant has found unexpectedly in a great number of experiments that the addition of specific anti-grease oxidizing agents and a glycine substance to the skin care composition can stabilize the skin care composition, prolong the storage time of the skin care composition to a certain extent, and avoid the negative effects that natural plant extracts slightly change the properties of the natural plant extracts along with the increase of the storage time and the change of the external environment. The applicant speculates that this may be due to the fact that the anti-grease oxidant, the extract of cinnamomum zeylanicum bark, contains terpenoids, which have unsaturated bonds as reactive sites, and interact with caprylyl glycine and potassium azelaioyl diglycine, and simultaneously, the terpenoids and other substances in the skin care product system synergistically act, and the molecules of the substances are tightly combined, so that the stability among the molecules of the composition is increased, the storage time of the skin care composition is prolonged, and the negative influence on the skin care composition caused by the change of the external environment is reduced. This effect is particularly pronounced with the skin care composition system provided by the present invention.
The skin care composition comprises a phase A, a phase B, a phase C and a phase D.
Preferably, in the phase A, 10 to 20 parts by weight of deionized water, 1 to 10 parts by weight of propylene glycol, 0.005 to 0.2 part by weight of sodium hyaluronate and 0.002 to 0.03 part by weight of disodium EDTA are added.
In phase B, 1-10 parts of butanediol, 0.2-0.8 part of p-hydroxyacetophenone and 0.2-0.8 part of 1, 2-hexanediol are added.
And the phase C comprises 0.005-1 part of the first mixture, 0.005-1 part of the second mixture and 0.001-5 parts of the third mixture.
Starting materials of the first mixture: 47-63 parts of deionized water, 30-40 parts of butanediol, 3-5 parts of radix scutellariae extract, 2-4 parts of radix sophorae flavescentis extract and 2-4 parts of liquorice root extract; starting materials of the second mixture: 42-45 parts of deionized water, 20-30 parts of caprylyl glycine, 18-25 parts of hexanediol, 8-8.5 parts of sarcosine and 2-5 parts of a Cinnamomum zeylanicum bark extract; starting materials of the third mixture: 64-68 parts of deionized water, 26-33 parts of potassium azeloyl diglycolate, 2-5 parts of butanediol, 0.8-1.0 part of phenoxyethanol, 0.05-0.15 part of ethylhexyl glycerol and 0.05-0.15 part of methylparaben.
In phase D, essence 0.001-0.2 parts, PEG-40 hydrogenated castor oil 0.004-0.8 parts.
The invention provides a preparation method of an oil-control acne-removing skin-care composition, which is characterized by comprising the following steps: (1) mixing: mixing the raw materials of the phase A at 80 ℃ to obtain a phase A; mixing the raw materials of the phase B at 25 ℃ to obtain a phase B; mixing the raw materials of the first mixture at 30 ℃, the raw materials of the second mixture at 30 ℃, the raw materials of the third mixture at 30 ℃, and mixing the first mixture, the second mixture and the third mixture at 80 ℃ to obtain a phase C; mixing the raw materials of the phase D at 25 ℃ to obtain a phase D; (2) cooling and heating: naturally cooling phase A to 45 deg.C, adding phase B, phase C and phase D, and stirring for 1.5 hr to obtain the composition with effects of controlling oil and removing acne.
Compared with the prior art, the invention has the following beneficial effects:
(1) the oil-control acne-removing composition provided by the invention is applied to a skin care product, and can effectively condition the skin and maintain the balance of skin tissue barriers.
(2) Can reduce the activity of sebaceous glands by inhibiting 5 alpha-reductase so as to reduce excessive secretion of sebum and achieve effective oil control effect.
(3) Inhibiting bacteria, improving immunity, reducing inflammation-inducing cytokine-interleukin 1L-1 alpha released by keratinocyte, controlling excessive keratinization and generation of peroxide free fatty acid, and eliminating acne radically.
(4) The specific anti-grease oxidant and the specific glyceric acid substances are added into the skin care product composition, so that the skin care product composition is more stable, the standing and storage time of the skin care product is prolonged to a certain extent, and the negative influence that the natural plant extract slightly changes the property of the natural plant extract along with the increase of the standing time and the change of the external environment is avoided.
(5) The invention can be widely applied to face cleaning, skin care and body beautifying products, and effectively improves the skin condition.
Drawings
Fig. 1 shows the results of performance test 2.
Detailed Description
Examples
The compositions of the examples were prepared from commercially available propylene glycol CAS No. 57-55-6, root extract of Scutellaria baicalensis Georgi, root extract of Sophora flavescens ait, root extract of Glycyrrhiza inflata Batalin, obtained from Shanghai Kao Biotech Co., Ltd, capryloyl glycine CAS No. 14246-53-8, bark extract of Cinnamomum zeylanicum, obtained from SEPPIC Co., USA, essence obtained from Guangzhou Fenghao essence Co., Ltd, type No. OSHU cherry flower.
Example 1
The present invention provides an oil-controlling and acne-removing skin care composition, which is prepared from glycine, an anti-oil and anti-acne oxidant and an azelaic acid derivative.
The skin care composition comprises a phase A, a phase B, a phase C and a phase D.
In phase A, by weight, 15 parts of deionized water, 5 parts of propylene glycol, 0.1 part of sodium hyaluronate and 0.002 part of EDTA disodium.
In phase B, 5 parts of butanediol, 0.4 part of p-hydroxyacetophenone and 0.4 part of 1, 2-hexanediol are added.
The phase C comprises 0.1 part of raw material of the first mixture, 0.3 part of raw material of the second mixture and 2 parts of raw material of the third mixture. Wherein the raw materials of the first mixture are: 50 parts of deionized water, 35 parts of butanediol, 4 parts of radix scutellariae extract, 3 parts of radix sophorae flavescentis extract and 3 parts of radix glycyrrhizae inflatae extract; starting materials of the second mixture: 43.75 parts of deionized water, 25 parts of glycine (specifically caprylyl glycine), 20 parts of hexanediol, 8.25 parts of sarcosine and 3 parts of grease-resistant oxidant (specifically cinnamon bark extract); starting materials of the third mixture: 65.9 parts of deionized water, 30 parts of azelaic acid derivative (specifically potassium azelate diglycinate), 3 parts of butanediol, 0.9 part of phenoxyethanol, 0.1 part of ethylhexyl glycerol and 0.1 part of methylparaben.
And in the phase D, 0.001 part of essence and 0.5 part of PEG-40 hydrogenated castor oil.
The embodiment also provides a preparation method of the oil-control acne-removing skin-care composition, which comprises the following steps: (1) mixing: mixing the raw materials of the phase A at 80 ℃ to obtain a phase A; mixing the raw materials of the phase B at 25 ℃ to obtain a phase B; mixing the raw materials of the first mixture at 30 ℃, the raw materials of the second mixture at 30 ℃, the raw materials of the third mixture at 30 ℃, and mixing the first mixture, the second mixture and the third mixture at 80 ℃ to obtain a phase C; mixing the raw materials of the phase D at 25 ℃ to obtain a phase D; (2) cooling and heating: naturally cooling phase A to 45 deg.C, adding phase B, phase C and phase D, and stirring for 1.5 hr to obtain the composition with effects of controlling oil and removing acne.
Example 2
The present example provides an oil-controlling, acne-removing and skin-caring composition, which is different from example 1 in that 27 parts by weight of capryloyl glycine and 4 parts by weight of Cinnamomum zeylanicum bark extract are added.
In phase C, 0.005 part of the starting material for the first mixture, 0.005 part of the starting material for the second mixture, and 0.001 part of the starting material for the third mixture.
The embodiment also provides a preparation method of the oil-control acne-removal skin-care composition, and the preparation method is the same as that of the embodiment 1.
Example 3
This example provides an oil and acne control skin care composition, which differs from example 1 in that in phase C, by weight, the first mixture comprises 0.005 parts of the first mixture, the second mixture comprises 0.005 parts of the second mixture, and the third mixture comprises 0.001 parts of the third mixture.
The embodiment also provides a preparation method of the oil-control acne-removal skin-care composition, and the preparation method is the same as that of the embodiment 1.
Example 4
The present example provides an oil-controlling, acne-removing and skin-caring composition, which is different from example 1 in that the weight parts of the raw materials of the second mixture in phase C are as follows: 44.30 parts of deionized water, 15 parts of glycine substances (specifically caprylyl glycine), 18 parts of hexanediol, 8.30 parts of sarcosine and 3 parts of grease-resistant oxidant (specifically Cinnamomum zeylanicum bark extract).
The embodiment also provides a preparation method of the oil-control acne-removal skin-care composition, and the preparation method is the same as that of the embodiment 1.
Example 5
The present example provides an oil-controlling, acne-removing and skin-caring composition, which is different from example 1 in that the weight parts of the raw materials of the second mixture in phase C are as follows: 47.20 parts of deionized water, 26 parts of glycine (specifically caprylyl glycine), 21 parts of hexanediol, 8.30 parts of sarcosine and 0.9 part of grease-resistant oxidant (specifically cinnamon bark extract).
The embodiment also provides a preparation method of the oil-control acne-removal skin-care composition, and the preparation method is the same as that of the embodiment 1.
And (3) performance testing:
1. the oil and acne controlling and skin care composition obtained in example 1 was tested according to QB/T2660 and the results are shown in Table 1:
TABLE 1
2. And (3) testing the oil content: the oil-control and acne-removal skin care composition obtained in the embodiment 1 and obtained in the embodiment 1 is coated on the skin surfaces on two sides of the forehead, the oil content is tested, and the oil content is measured again after 2 hours to obtain a skin oil content change value; taking another blank group, not coating any substance on the skin surface on two sides of forehead, measuring oil content before and after 2h, respectively, to obtain skin oil content variation value, and the result is shown in figure 1, and the ordinate unit of figure 1 is%.
3. Sensory testing: the oil-controlling and acne-removing skin care compositions obtained in examples 1-5 were left at 25 ℃ for 24 hours, and the appearance was observed, wherein the compositions obtained in examples 1-3 were all clear liquids, and the compositions obtained in examples 4-5 were not clear.
4. And (3) heat resistance test: the pH values of the oil-controlling, acne-removing skin care compositions obtained in examples 1 to 5 were measured using a pH meter, maintained at 40 ℃ for 24 hours, and measured again, with the results shown in table 2:
TABLE 2
5. Cold resistance test: the pH values of the oil-controlling, acne-removing skin care compositions obtained in examples 1 to 5 were measured using a pH meter, and maintained at 5 ℃ for 24 hours, and the pH values were measured again, with the results as shown in table 3:
TABLE 3
| Examples | pH value (before standing at 5 degree C) | pH value (after standing at 5 ℃ C.) |
| 1 | 5.7 | 5.7 |
| 2 | 5.8 | 5.8 |
| 3 | 5.7 | 5.7 |
| 4 | 6.2 | 6.0 |
| 5 | 5.1 | 5.9 |
6. And (3) testing microorganisms: the oil-controlling and acne-removing skin care compositions obtained in examples 1 to 5 were tested for staphylococcus aureus and pseudomonas aeruginosa according to the technical specifications for cosmetic safety (2015 edition). The oil-control and acne-removal skin care compositions obtained in examples 1-5 have no staphylococcus aureus or pseudomonas aeruginosa detected.
It can be seen that the oil-controlling and acne-removing skin care compositions obtained in examples 1 to 3 have good heat resistance and cold resistance, do not breed bacteria, are beneficial to long-term storage, and have significant oil-controlling effect when applied to the skin, especially on both sides of the forehead.
Claims (10)
1. The oil-control acne-removing skin-care composition is characterized in that raw materials of the oil-control acne-removing skin-care composition comprise glycine substances, an anti-oil and fat oxidizing agent and azelaic acid derivatives.
2. The oil-controlling, acne-removing skin care composition according to claim 1 wherein said glycine is selected from capryloyl glycine and/or lauroyl glycine.
3. The oil and acne controlling and removing skin care composition according to claim 2 wherein the anti-sebum oxidant is selected from one or more of cinnamomum zeylanicum bark extract, nordihydroguaiaretic acid, gallnut extract.
4. The oil and acne controlling and removing skin care composition according to claim 2 wherein said azelaic acid derivative is selected from one or more of the group consisting of azelaic acid cyclodextrin inclusion compound, potassium azelaiyl diglycinate, potassium azelate amino acid salt.
5. The oil-controlling acne-removing skin care composition according to claim 1, wherein the raw materials of the oil-controlling acne-removing skin care composition comprise deionized water, propylene glycol, sodium hyaluronate and disodium EDTA.
6. The oil-controlling, acne-removing skin care composition according to claim 1, wherein the raw materials of the oil-controlling, acne-removing skin care composition comprise butanediol, p-hydroxyacetophenone, 1, 2-hexanediol.
7. The oil-controlling, acne-removing skin care composition according to claim 1 further comprising deionized water, butylene glycol, scutellaria root extract, sophorae flavescentis root extract, glycyrrhiza inflate root extract.
8. The oil-controlling, acne-removing and skin-care composition according to claim 1, wherein the raw materials of the oil-controlling, acne-removing and skin-care composition further comprise hexylene glycol, sarcosine, butylene glycol, phenoxyethanol, ethylhexylglycerin, and methylparaben.
9. The oil-controlling and acne-removing skin care composition according to claim 3, wherein the raw materials of the oil-controlling and acne-removing skin care composition comprise essence and PEG-40 hydrogenated castor oil, and the weight ratio of the essence to the PEG-40 hydrogenated castor oil is (0.001-0.2): (0.004-0.8).
10. A method of preparing an oil-controlling, acne-removing skin care composition according to any of claims 1 to 9, comprising the steps of: (1) mixing; (2) and cooling and heating.
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