JP2017128557A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide cosmetics that comprise horse milk and keep moisturizing effect.SOLUTION: The cosmetics comprise horse milk, and a second component selected from ceramide, collagen, stem cell culture extract, fermentation extract and vegetable oil.SELECTED DRAWING: None

Description

  The present invention relates to a cosmetic containing horse milk that can maintain a moisturizing effect.

  Conventionally, in order to provide a moisturizing ingredient that prevents the skin from drying and moisturizes the skin, various active ingredients have been studied.

  However, in order to moisturize the skin, it is necessary to maintain the moisturizing effect of the moisturizing component, but it was difficult to maintain it for a long time.

  On the other hand, horse milk is said to have an ingredient composition similar to human breast milk. For example, as described in Patent Document 1, it is blended in pharmaceutical, dermatological and cosmetic compositions and has various effects. It is described that there is. However, Patent Document 1 does not describe the effect of maintaining the moisturizing effect on horse milk.

JP-T 8-505630

  The present invention has been made to solve the above-described problems, and provides a cosmetic that can maintain a moisturizing effect for a long time.

The present inventors have found that the moisturizing effect can be maintained for a long time by using horse milk and a specific second component in combination, and have completed the present invention.
That is, the cosmetic of the present invention is characterized by comprising horse milk and at least one second component selected from ceramide, collagen, stem cell culture extract, fermentation extract and vegetable oil.

The second component is preferably at least one selected from stem cell culture extract, fermentation extract and vegetable oil.
The stem cell culture extract is preferably an Arganian spinosa callus culture extract, a grape fruit cell extract, or an apple fruit culture cell extract.
The fermented extract is preferably an Alteromonas fermented extract.
Moreover, as said vegetable oil, it is preferable that they are argan oil, baobab seed oil, theobromaglandic florum seed oil, mango seed oil, Sclerocaria berea seed oil, and Shirobanarurubin seed oil.

  According to the cosmetic of the present invention, the moisturizing effect can be maintained for a long time.

  The measurement result of the stratum corneum moisture content is shown in a graph.   The measurement result of transepidermal water loss is shown in a graph.

  Hereinafter, the cosmetic according to the present invention will be described.

  The cosmetic of the present invention is characterized by containing horse milk and at least one second component selected from ceramide, collagen, plant stem cell culture extract, fermentation extract and vegetable oil.

  The amount of horse milk blended in the present cosmetic is preferably 0.001 wt% to 20 wt%, more preferably 0.02 wt% to 10 wt%.

  Examples of the ceramide include ceramides such as natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extract.

The collagen may be animal-derived collagen or synthetic collagen. In addition to collagen protein, collagen peptide obtained by hydrolyzing collagen protein, or collagen molecule treated with protease, telopeptide Includes atelocollagen with portions removed. As animal-derived collagen, collagen derived from fish is particularly preferable.
The average molecular weight (weight average molecular weight) of the collagen of the present invention is not particularly limited, but is preferably 500 to 100,000, more preferably 1,000 to 50,000, and more preferably 2,000 to 15,000. It is particularly preferable that 3000 to 10,000 is most preferable.

The plant stem cell culture extract is an extract of a culture solution in which a stem cell line is established by inducing tollability callus from plant seeds, leaves, stems, roots, and the like.
The plant stem cell culture extract includes: rhododendron callus culture extract, American morning glory callus culture extract, American leech callus culture extract, Argania spinosa callus culture extract, aloe vera callus culture extract, rice callus culture extract, Edelweiss callus culture extract, eringium maritim Callus culture solution, Oxidendron Arborium leaf / stem callus culture extract, Panax ginseng callus culture extract, Orange callus culture extract, Caetomorpha solitaria callus culture extract, Crissum maritimum callus culture solution, Globularia cordiphoria callus culture extract , Comfrey callus culture extract, Saponaria pmira callus culture extract, Shimakangi callus culture extract, Shobu callus culture extract, Hypericum callus culture extract Cultured cell extract, Pear fruit cell culture extract, Sequoia occulus callus culture extract, Soil minerals / lilac leaf cell culture extract, Daisanchi callus culture extract, Damask rose callus culture extract, Damask rose placenta culture extract, Chacarus culture Extract, centella growth point cell culture, tomato callus culture extract, tomato leaf cell culture extract, carrot callus culture extract, hybrid rose callus culture extract, lotus callus culture extract, lotus placenta culture extract, hijiki callus culture extract, fulan callus culture extract, Psylanthus Bengalensis Leaf Cell Culture Extract, Grape Callus Culture Extract, Hosobabarengiku Cultured Cell Extract, Hosobabarengiku Root Cultured Cell Extract, Mishima Psychocarus Culture Extract, Milotanum Verifolia callus culture extract, Muggecarus culture extract, Meshimakobu / Yamaguwa tree culture extract, Mebuki hairy root culture extract, Peach callus culture extract, Rye placenta culture extract solution, Lilac leaf culture cell extract, Mungbean growth point cell culture extract, Apple fruit Examples include cultured cell extract, rhododendron ferruginium leaf cultured cell extract, and wakame cultured cell extract. Among these, preferable plant stem cell culture extracts include Argania spinosa callus culture extract, grape fruit cell extract, and apple fruit culture cell extract, depending on availability.

  The fermented extract is an extract from a fermented product such as bacteria or fungi. As this fermented extract, Aspergillus / rice fermented extract, Aspergillus / chestnut fermented extract, Ganoderma amboynense / apple fermented extract, Saccharomyces / barley seed fermented extract, Alteromonas fermented extract, Soybean fermented extract, Bacillus / soybean fermented extract , Bifidobacteria fermentation extract, yeast fermentation extract and the like. Of these, the fermented Alteromonas extract is preferable.

  Examples of the vegetable oils include avocado oil, almond oil, olive oil, cacao butter, carnauba wax, candelilla wax, sesame oil, safflower oil, soybean oil, soybean phospholipid, camellia oil, persic oil, castor oil, cottonseed oil, molasses, palm oil , Anise oil, sesame oil, orange oil, chamomile oil, cucumber oil, kyounin oil, grape seed oil, kukui nut oil, rice bran oil, wheat germ oil, burdock seed oil, rice germ oil, sasanqua oil, shea fat, juzudama oil, Spearmint oil, sage oil, thyme oil, tea seed oil, clove oil, evening primrose oil, turpentine oil, spruce oil, pepper oil, rapeseed oil, wild rose oil, palm kernel oil, palm oil, peppermint oil, pearl oil, sunflower oil, Grape seed oil, hazelnut oil, jojoba oil, macadamia nut oil, meadow foam oil, meadow Homer seed oil, Meadowfoam-δ-lactone, Mortiera oil, Eucalyptus oil, Peanut oil, Lavender oil, Rosehip oil, Rosemary oil, Roman chamomile oil, Argan oil, Argania spinosa kernel oil, Baobab oil, Baobab seed oil , Mango seed oil, Shirobanarupin seed oil, Sclerocaria birea oil, Sclerocaria birea seed oil, Mulmur fat, Inca mega oil, Theobroma grunge florum seed fat, Babas fat, Borage oil, Turquoise seed oil, Bilberry seed Oil, cowberry seed oil, strawberry seed oil, black currant seed oil, moringa oil, prunes seed oil, cholesterol, camellia oil, yamato camellia oil, sandalwood extract, yellowfin bark extract, barley extract, turtle oil, mink oil, egg yolk oil, flaxseed Oil, eno oil, Examples include kaya oil, cinnagiri oil, Japanese kiri oil, germ oil, hydrogenated coconut oil and the like. Among these, preferable vegetable oils include argan oil, baobab oil, theobromaglandic florum seed fat, mango seed oil, white rose lupine seed oil, sclerocaria birea seed oil and the like.

These second components may be used alone or in combination of two or more.
In addition, the blending amount of the second component in the cosmetic is preferably 0.001% by weight to 20% by weight and more preferably 0.002% by weight to 10% by weight for each single component. Furthermore, the total amount of the second component is preferably about 0.002 to 30% by weight.

  The cosmetics according to the present invention include surfactants, pH adjusters, fats and oils, moisturizers, thickeners, chelating agents, antiseptics, anti-inflammatory agents, which are generally used as cosmetic ingredients in addition to the above components. Agents, extracts, antioxidants, solvents, ultraviolet absorbers, pigments, fragrances, and the like may be appropriately blended.

  Although there is no restriction | limiting in particular as a kind of cosmetics of this invention, Skin external preparations, such as cosmetics for hair, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and ointments, are mentioned as a preferable thing. Moreover, the cosmetics of this invention can employ | adopt the various dosage forms normally used as cosmetics, and can manufacture them according to a normal method.

  Although it demonstrates still in detail based on a following example, the cosmetics which concern on this invention are not limited to these.

(Preparation of lotion 1)
Each component was dissolved and mixed at the blending amounts shown in Table 1 to prepare lotions for Examples and Comparative Examples. In the table, the composition is expressed in wt%.

<Evaluation 1 of moisturizing effect> (Durability of moisturizing effect: measurement of stratum corneum moisture content)
The moisturizing effects of the skin lotions of the examples and comparative examples shown in Table 1 were individually evaluated on a monitor. Specifically, the monitor was acclimated for 20 minutes in a constant temperature and humidity chamber at a temperature of 21 ± 2 ° C. and a humidity of 50 ± 3%, and the amount of horny water in the upper arm flexion (measurement site) was determined using SKICON-200EX (IBS). The electrical conductivity of the stratum corneum was measured using Thereafter, each lotion (20 μL) is applied to the measurement site of the monitor, and the electrical conductivity of the stratum corneum is measured over time from 5 minutes after application. The measurement was performed 5 times, and the average value of 3 times was used, and the amount of water increase was calculated based on the value before coating. The results are shown in Table 1.

  The results are shown in FIG. Cosmetics combining horse milk and collagen, fermented extract or stem cell extract according to the present invention are cosmetics using horse milk hyaluronic acid, collagen and stem cell extract alone, or cosmetics using horse milk and hyaluronic acid in combination. It was found that the moisturizing effect was remarkably high and maintained for a long time.

(Preparation of lotion 2)
The lotions of Examples and Comparative Examples were prepared with the blending amounts shown in Table 2. More specifically, the component (3) and the component (4) were mixed and then dissolved by heating with the component (2). A mixture of the component (1) and purified water was added thereto, and the mixture was stirred until uniform.

<Evaluation 2 of moisturizing effect> (Durability of moisturizing effect: measurement of transepidermal water loss (TEWL))
The moisturizing effects of the skin lotions of Examples and Comparative Examples shown in Table 2 were individually evaluated on a monitor. Specifically, the monitor was acclimated for 20 minutes in a constant temperature and humidity chamber at a temperature of 21 ± 2 ° C. and a humidity of 50 ± 3%, and the amount of transepidermal water loss at the upper arm flexion (measurement site) was measured using Vapo Asahi Biomed). Then, each lotion (20 μL) was applied to the measurement site of the monitor, 30 minutes after application, 120 minutes later, measured 3 times at 1 minute intervals, using the average value of all values, and using the value before application as a reference, TEWL reduction was calculated. The results are shown in Table 2.

  The results are shown in FIG. Horse milk and ceramide or cupuas butter according to the present invention (theobroma gland florum seed oil), lupine oil (white rose rubin seed oil), argan oil (argania spinosa kernel oil), baobab oil, mango seed oil, marula oil (sclerocali It was found that the combined use with vegetable oils such as Avirea seed oil) suppressed transepidermal water evaporation, had a significantly higher moisturizing effect than horse milk and vegetable oil alone, and lasted for a long time.

Claims (5)

With horse milk,
At least one second component selected from ceramide, collagen, vegetable oil, stem cell culture extract, and fermentation extract;
Including cosmetics.   The cosmetic according to claim 1, wherein the second component is at least one selected from vegetable oil, stem cell culture extract, and fermented extract.   3. The plant oil according to claim 1, wherein the vegetable oil is at least one selected from argan oil, baobab seed oil, theobroma gland florum seed oil, mango seed oil, sclerocaria birea seed oil, and white vana rubin seed oil. Cosmetics described.   The cosmetic according to any one of claims 1 to 3, wherein the stem cell culture extract is at least one selected from an Arganian spinosa callus culture extract, a grape fruit cell extract, and an apple fruit culture cell extract.   The cosmetic according to any one of claims 1 to 4, wherein the fermented extract is an Alteromonas fermented extract.

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