JP6732208B2 - Cosmetics - Google Patents

Description

The present invention relates to a cosmetic containing horse milk that can maintain a moisturizing effect.

Conventionally, in order to prevent the skin from drying and to provide a moisturizing component that moisturizes the skin, various active ingredients have been studied for blending.

However, in order to moisturize the skin, it is necessary to maintain the moisturizing effect of the moisturizing component, but it is difficult to maintain it for a long time.

On the other hand, horse milk is said to have a component composition similar to that of human breast milk. For example, as described in Patent Document 1, it is blended in pharmaceutical, dermatological and cosmetic compositions to have various effects. It is stated that there is. However, Patent Document 1 does not describe the effect of maintaining a moisturizing effect on horse milk.

Japanese Patent Publication No. 8-505630

The present invention has been made to solve the above-described problems, and provides a cosmetic that can maintain the moisturizing effect for a long time.

The present inventors have found that the moisturizing effect can be maintained for a long time by using horse milk in combination with a specific second component, and have completed the present invention.
That is, the cosmetic of the present invention is characterized by containing horse milk and at least one second component selected from ceramide, collagen, stem cell culture extract, fermented extract and vegetable oil.

The second component is preferably at least one selected from stem cell culture extract, fermented extract and vegetable oil.
The stem cell culture extract is preferably Argania spinosa callus culture extract, grape fruit cell extract, or apple fruit culture cell extract.
The fermented extract is preferably Alteromonas fermented extract.
In addition, the above-mentioned vegetable oil is preferably argan oil, baobab seed oil, theobromaglandiflorum seed oil, mango seed oil, sclerocarriavillea seed oil, and white rubin rubin seed oil.

According to the cosmetic of the present invention, the moisturizing effect can be maintained for a long time.

It is a graph showing the measurement results of the stratum corneum water content. It is a graph showing the measurement results of transepidermal water loss.

Hereinafter, the cosmetic material according to the present invention will be described.

The cosmetic of the present invention is characterized by containing horse milk and at least one second component selected from ceramide, collagen, plant stem cell culture extract, fermented extract and vegetable oil.

The blending amount of horse milk in the present cosmetic composition is preferably 0.001% by weight to 20% by weight, more preferably 0.02% by weight to 10% by weight.

Examples of the ceramides include natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides, and sugar-ceramide-containing extracts.

The collagen may be animal-derived collagen or synthetic collagen. In addition to collagen proteins, collagen peptides obtained by hydrolyzing collagen proteins and collagen molecules treated with protease to give telopeptides Includes atelocollagen with parts removed. As animal-derived collagen, fish-derived collagen is particularly preferable.
Further, the average molecular weight (weight average molecular weight) of the collagen of the present invention is not particularly limited, but is, for example, preferably 500 to 100,000, more preferably 1,000 to 50,000, further preferably 2,000 to 15,000. Is particularly preferable, and 3000 to 10000 is most preferable.

The above-mentioned plant stem cell culture extract is an extract of a culture solution in which a totipotent callus has been induced from plant seeds, leaves, stems, roots, etc. and then cultured to establish a stem cell line.
As the plant stem cell culture extract, schizophrenia callus culture extract, American morning glory callus culture extract, American hirugi callus culture extract, argania spinosa callus culture extract, aloe vera callus culture extract, rice callus culture extract, edelweiss callus culture extract, eringium maritimum Callus culture solution, Oxydendron arboreum leaf/stem callus culture extract, Panax ginseng callus culture extract, Orange callus culture extract, Kaetomorpha solitaria callus culture extract, Chris mum maritimum callus culture solution, Globularia cordifolia callus culture extract , Comfrey callus culture extract, saponaria pumila callus culture extract, striped callus callus culture extract, gypsum callus culture extract, St. John's wort callus culture extract, Eucommia ulmoides culture cell extract, pear fruit cell culture extract, sequoia osugi callus culture extract, soil mineral /Lilac leaf cell culture extract, Daisantic callus culture extract, Damask rose callus culture extract, Damask rose placenta culture extract, Chacallus culture extract, Centella asiatica cell culture, Tomato callus culture extract, Tomato leaf cell culture extract, Carrot Callus culture extract, hybrid rose callus culture extract, lotus callus culture extract, lotus placenta culture extract, hydrangea callus culture extract, francalus callus culture extract, psilenzus bengalensis leaf cell culture extract, grape callus culture extract, Drosophila chinensis cultured cell extract, Drosophila chinensis root Cultured cell extract, Mishima Psychocallus culture extract, Milothamnus flaverifolia callus culture extract, Mukugecallus culture extract, Mesimacob/Yamaguchi tree culture extract, Meboki hairy root culture extract, Peach callus culture extract, Lyme zodiac culture extract, lilac leaf Cultured cell extract, mung bean cell culture extract, apple fruit culture cell extract, rhododendron ferguineum leaf culture cell extract, wakame culture cell extract and the like can be mentioned. Among these, preferable plant stem cell culture extracts include Argania spinosa callus culture extract, grape fruit cell extract, and apple fruit culture cell extract, depending on availability and the like.

The fermented extract is an extract from a fermented product of bacteria, fungi and the like. This fermented extract includes Aspergillus/rice fermented extract, Aspergillus/chestnut astringent skin fermented extract, Ganoderma amboinense/apple fermented extract liquid, Saccharomyces/barley seed fermented extract, Alteromonas fermented extract, soybean fermented extract, Bacillus/soybean fermented extract , Bifidobacteria fermented extract, yeast fermented extract and the like. Of these, Alteromonas fermented extract is preferable.

Examples of the vegetable oil include avocado oil, almond oil, olive oil, cacao butter, carnauba wax, candelilla wax, sesame oil, safflower oil, soybean oil, soybean phospholipid, camellia oil, persic oil, castor oil, cottonseed oil, mokuro, coconut oil. , Anise oil, perilla oil, orange oil, chamomile oil, cucumber oil, kyounin oil, grape seed oil, kukui nut oil, rice bran oil, wheat germ oil, burdock seed oil, rice germ oil, southern oil, shea butter, juzdama oil, Spearmint oil, sage oil, thyme oil, teaseed oil, clove oil, evening primrose oil, turpentine oil, spruce oil, pepper oil, rapeseed oil, nobara oil, palm kernel oil, palm oil, peppermint oil, pearl barley oil, sunflower oil, Grape seed oil, hazelnut oil, jojoba oil, macadamia nut oil, meadowfoam oil, meadowfoam seed oil, meadowfoam-delta-lactone, Mortierella oil, eucalyptus oil, peanut oil, lavender oil, rosehip oil, rosemary oil, Rome Chamomile oil, argan oil, argania spinosa kernel oil, baobab oil, baobab seed oil, mango seed oil, white lupine seed oil, sclerocaria bilea oil, sclerocaria birea seed oil, murmur fat, inca mega oil, Theobroma grange florum seed oil, babassu oil, borage oil, cranberry seed oil, bilberry seed oil, cowberry seed oil, strawberry seed oil, black currant seed oil, moringa oil, pruned seed oil, cholesterol, camellia oil, camellia oil, sandalwood extract , Yellowfin bark extract, barley extract, turtle oil, mink oil, egg yolk oil, linseed oil, eno oil, kaya oil, cinnamon oil, Japanese tung oil, germ oil, hardened coconut oil and the like. Among these, preferable vegetable oils include argan oil, baobab oil, theobroma grange florum seed oil, mango seed oil, white lupine seed oil, and sclerocaraviria seed oil.

These second components may be used alone or in combination of two or more.
Moreover, the blending amount of the second component in the present cosmetic composition is preferably 0.001% by weight to 20% by weight, and more preferably 0.002% by weight to 10% by weight, for each single component. Furthermore, the total amount of the second component is preferably about 0.002% by weight to 30% by weight.

In addition to the above-mentioned components, the cosmetics according to the present invention are generally used as a blending component of cosmetics, including surfactants, pH adjusters, oils and fats, moisturizers, thickeners, chelating agents, preservatives and anti-inflammatory agents. Agents, extracts, antioxidants, solvents, ultraviolet absorbers, dyes, fragrances and the like may be appropriately mixed.

The type of the cosmetic of the present invention is not particularly limited, but preferable examples are external cosmetics for hair, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, ointments and the like. Further, the cosmetic of the present invention can employ various dosage forms that are usually used as cosmetics, and can be manufactured according to a usual method.

The present invention will be described in more detail based on the following examples, but the cosmetics according to the present invention are not limited to these.

(Preparation 1 of lotion)
The components were dissolved and mixed in the blending amounts shown in Table 1 to prepare lotions of Examples and Comparative Examples. In the table, the composition is shown in% by weight.

<Evaluation 1 of moisturizing effect> (Persistence of moisturizing effect: measurement of stratum corneum water content)
The moisturizing effect of the lotions of Examples and Comparative Examples shown in Table 1 were individually evaluated by a monitor. Specifically, the monitor is acclimatized for 20 minutes in a constant temperature and humidity room at a temperature of 21±2° C. and a humidity of 50±3%, and the amount of keratin water in the upper arm flexion (measurement site) of the monitor is determined by SKICON-200EX (IBS). The electrical conductivity of the stratum corneum was measured by (made by KK). Then, each lotion (20 μL) is applied to the measurement site of the monitor, and 5 minutes after the application, the electrical conductivity of the stratum corneum is measured over time. The measurement was performed 5 times and the average value of 3 times was used, and the amount of increase in water was calculated based on the value before coating. The results are shown in Table 1.

Moreover, the result is shown in FIG. Cosmetics using horse milk and collagen, fermented extract or stem cell extract in combination according to the present invention, horse milk hyaluronic acid, collagen, cosmetics using stem cell extract alone, or cosmetics using horse milk and hyaluronic acid in combination It was found that the moisturizing effect was extremely high and was maintained for a long time.

(Preparation of lotion 2)
The lotions of Examples and Comparative Examples were prepared with the compounding amounts shown in Table 2. More specifically, after mixing the components (3) and (4), the components (2) were heated and dissolved. A mixture of the component (1) and purified water was added thereto, and the mixture was stirred until it became uniform.

<Evaluation 2 of moisturizing effect> (Persistence of moisturizing effect: measurement of transepidermal water loss (TEWL))
The moisturizing effect of the lotions of Examples and Comparative Examples shown in Table 2 were individually evaluated by a monitor. Specifically, the monitor is acclimatized for 20 minutes in a constant temperature and humidity room at a temperature of 21±2° C. and a humidity of 50±3%, and the transepidermal water loss in the upper arm flexion (measurement site) of the monitor is measured by Vapo scan( Asahi Biomed). After that, each lotion (20 μL) was applied to the measurement site of the monitor, and after 30 minutes and 120 minutes after application, measurement was performed 3 times at 1-minute intervals, and the average value of all numerical values was used, with the value before application as the standard. The TEWL reduction amount was calculated. The results are shown in Table 2.

The results are shown in FIG. Horse milk and ceramide or cupua butter (theobroma grange florum seed oil), lupine oil (white rubin seed oil) argan oil (argania spinosa kernel oil), baobab oil, mango seed oil, marula oil (sclerocari) according to the present invention It was found that the combined use with vegetable oils such as Avilea seed oil suppresses transepidermal water evaporation, has a significantly higher moisturizing effect than horse milk and vegetable oil alone, and lasts for a long time.

Claims (1)

Horse milk,
A cosmetic containing at least one selected from Argania spinosa callus culture extract, grape fruit cell extract, apple fruit culture cell extract, and Alteromonas fermented extract .

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