KR20110125722A - Composition for moisturizing skin and composition for preventing hair loss or promoting hair generation having the extract of cinnamomum camphora sieb - Google Patents

Abstract

PURPOSE: A composition for skin moisturizing and promoting hair growth using Cinnamomum camphora extract is provided to suppress 5alpha-reductase. CONSTITUTION: A composition for skin moisturizing contains Cinnamomum camphora extract. A composition for promoting hair growth or preventing alopecia contains the extract. The extract is isolated using leaves, stems, fruits, seeds, flowers, or mixture thereof using water, ethanol, or mixture solvent thereof. The composition is a cosmetic composition for skin or hair. The cosmetic composition is used in the form of emulsion, lotion, cream, gel, pack, or powder.

Description

Composition for Moisturizing Skin and Composition for Preventing Hair Loss or Promoting Hair Generation Having the Extract of Cinnamomum camphora Sieb}

The present invention discloses a skin moisturizing composition using a camphor extract and a composition for promoting hair growth or preventing hair loss.

Camphor tree (Cinnamomum camphora) is also known as camphor (樟腦 木). As an evergreen tree, the leaves are oval, oval, shiny and fragrant. Flowers are bisexual. Around May, small yellow-white flowers bloom in axillary cones.

It is a tree native to Jeju Island in Korea (Lee, N. H. et al., Kor. J. Pharmacogn., 32 (3), pp175-180, 2001). It is widely distributed in Japan, China, and Taiwan.

This tree has a valuable value because it can be used as a valuable scent of camphor. Camphor is an oil obtained by distilling tree trunks and roots into water and distilling them into water vapor. It is used as a raw material for making insect repellents and insecticides. have.

Recently, additionally known activities for camphor tree include antidiabetic activity of camphor leaf extract (domestic patent No. 706134), whitening activity of camphor extract (Domestic Patent No. 669694), and anti-inflammatory activity of camphor extract (Domestic Patent No. 623972). have.

The present invention discloses a skin moisturizing activity and hair growth promoting or hair loss prevention activity of camphor extract.

An object of the present invention is to provide a skin moisturizing composition of camphor extract.

Another object of the present invention to provide a composition for promoting hair growth or preventing hair loss of camphor extract.

The present invention shows that 70% ethanol extract of camphor seed oil and camphor leaf and stem has skin moisturizing activity and hair growth promoting or anti-hair loss activity in actual clinical trials, and promotes hair loss, as shown in the following examples and experimental examples. It was completed by confirming that it inhibits the activity of known 5α-reductase.

The present invention is provided based on these experimental results.

In one aspect, the present invention relates to a skin moisturizing composition comprising a camphor extract, and in another aspect, to a hair growth promoting or hair loss preventing composition comprising a camphor extract.

In the present specification, the term "camphor extract" is obtained by compressing the leaves, stems, fruits, seeds and / or flowers of camphor, which are the extraction targets, regardless of the extraction method, or having 1 to 4 carbon atoms such as water, methanol, ethanol, butanol, etc. An extract obtained by dipping into a lower alcohol or a mixed solvent thereof is meant. In the case of a solvent extract, the meaning of the extract includes a concentrated liquid extract or a solid extract from which the extraction solvent is removed, and the extraction method may be cold immersion, reflux, warming, or ultrasonic wave, as long as the extraction object is immersed in an extraction solvent. Any method such as spinning may be applied. Nevertheless, preferably, the leaves, stems, fruits, seeds and / or flowers of the camphor tree to be extracted are obtained using water, ethanol or a mixed solvent thereof, or an extract obtained by drying and crushing the camphor seed, followed by compression.

In addition, in the present specification, the meaning of the "active ingredient" means a component that can exhibit activity alone or in combination with a carrier that is not active alone.

In addition, in this specification, said "hair loss" is meant to include all the symptoms classified as hair loss in the art regardless of the direct or indirect cause of the occurrence. That is, it includes all the symptoms of hair loss due to poor blood circulation, excessive secretion of sebum due to excessive production of dihydrotestosterone, deterioration of the scalp function due to peroxide or bacteria, aging, genetic factors, stress, and a combination of these.

Terms not specifically defined herein are in accordance with the Korean dictionary meaning or the meaning commonly accepted in the art.

On the other hand, in the skin moisturizing composition of the present invention and hair loss prevention or hair growth promoting composition (hereinafter "composition" of the present invention), its active ingredient is a camphor extract as long as it can exhibit skin moisturizing, hair loss prevention or hair growth promoting activity. It may be included in any amount (effective amount), depending on the formulation, formulation purpose, and the like, a typical effective amount will be determined within the range of 0.01% to 30.0% by weight based on the total weight of the composition. Here, "effective amount" refers to the amount of the active ingredient that can promote skin moisturizing, hair loss prevention or hair growth. Such effective amounts can be determined experimentally within the range of ordinary skill in the art.

The composition of the present invention may be regarded as a hair cosmetics composition or a cosmetic composition as an external preparation for skin in a specific embodiment.

When the composition of the present invention is understood as a hair cosmetic composition or a skin cosmetic composition, the cosmetic composition can be prepared in various formulations, such as emulsions, lotions, creams (oil-in-water, water-in-oil, multiphase), solutions, suspensions (Anhydrous and aqueous), anhydrous products (oil and glycols), gels, packs, powders and the like.

The composition of the present invention may comprise an acceptable carrier in cosmetic preparations in addition to camphor extract.

Examples of the carrier include alcohols, oils, surfactants, fatty acids, silicone oils, preservatives, wetting agents, moisturizers, viscosity modifiers, emulsions, stabilizers, sunscreens, colorants, flavors, diluents, and the like.

Specific compounds or compositions that can be used as the alcohols, oils, surfactants, fatty acids, silicone oils, preservatives, wetting agents, moisturizers, viscosity modifiers, emulsions, stabilizers, sunscreens, colorants, fragrances, diluents and the like are already known in the art. Therefore, those skilled in the art can select and use appropriate compounds or compositions.

Examples of the alcohols include water-soluble polyhydric alcohols such as higher alcohols, propylene glycol, 1,3-butylene glycol, glycerin, sorbitol, polyethylene glycol, and the like, and examples of the oil include avocado oil, palm oil, tallow oil, Jojoba oil, and the like. Examples of the preservative include ethyl paraben and butyl paraben. Examples of the moisturizing agent include hyaluronic acid, chondroitin sulfate, pyrrolidone carboxylate, and the like, and diluents such as ethanol and isopropanol. Can be mentioned.

The composition of the present invention may be regarded as a shampoo composition in another specific embodiment.

When the composition of the present invention is identified as a shampoo composition, the shampoo composition of the present invention may be prepared including a carrier which is acceptable in the shampoo preparation in addition to camphor extract, and such carriers include surfactants, bubble enhancers, emulsifiers and thickeners. , Perfumes (preservatives), preservatives, pH adjusting agents, fungicides, anti-dandruff agents, tonic agents, moisturizing agents and the like.

The surfactants, bubble enhancers, emulsifiers, thickeners, perfumes (hydrotrope), preservatives, pH adjusting agents, fungicides, anti-dandruff agents, tonic agents and the like can be used in the art, for example, surfactants As the alkyl ether sulfate S (Alcohol Ethoxy Sulfate; Sodium Lauryl Ethoxylated Sulfate), alkyl sulfate (Alcohol Sulfate), acyl sarcosinate, acyl glutamate, phosphate ester, sucrose ester, etc. may be used. Alkanolamide and amine oxide may be used. As the thickener, sodium chloride, sodium sulfate, starch, texturing, and the like may be used. As the perfume, ethanol, butyl alcohol, propylene glycol, etc. may be used. Etc. can be used.

The composition of the present invention may be regarded as a soap composition in another specific embodiment.

When the composition of the present invention is understood as a soap composition, the soap composition of the present invention may be prepared by including an active ingredient thereof in a soap base, and may be prepared by including a skin moisturizer, an emulsifier, a hard water softener, and the like as an additive. .

As the soap base material, vegetable oils such as palm oil, palm oil, soybean oil, perm oil, olive oil, palm kernels, or animal oils such as tallow, pork, sunny and fish oils can be used, and the skin moisturizing agent is glycerin, erythritol and polyethylene glycol. , Propylene glycol, butylene glycol, pentylene glycol, hexyl glycol, isopropyl myristate, silicone derivatives, aloe vera, sorbitol and the like can be used, the emulsifiers include natural oils, wax fatty alcohols, hydrocarbons, natural plant extracts, etc. May be used, and tetrasodium idieti or the like may be used as the water softener.

The soap composition of the present invention may further include an antimicrobial agent, a dispersant, a foam inhibitor, a solvent, a scale inhibitor, a corrosion inhibitor, a perfume, a pigment, a metal ion sequestrant, an antioxidant, a preservative, and the like as an additive.

As described above, according to the present invention can provide a composition for skin moisturizing using the camphor extract and a composition for promoting hair growth or preventing hair loss.

The compositions of the present invention can be commercialized and used as mimic cosmetic compositions, skin cosmetic compositions, shampoo compositions or soap compositions.

Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these examples and experimental examples.

< Example > Preparation of Camphor Extract

Example 1 Preparation of Camphor Seed Oil

After collecting and washing camphor seeds and crushing them by using a pulverizer, the pulverized product was dried by using a hot plate at a temperature of approximately 100-110 ° C. for 15 minutes, and then pressed into a hydraulic press to pressurize at high pressure to extract oil components in the camphor seeds. . The collected oil was purified by filtration through a filter and used in the experiment.

Example 2 Preparation of Camphor Leaf Extract

The leaves and stems of the camphor tree were harvested and dried, and then crushed with a mill and crushed 100 g of fine powder obtained by dipping in 2 L of 80% ethanol and extracted at room temperature for 24 hours. The extract was filtered and concentrated under reduced pressure to obtain a powdery extract that was used in the experiment.

< Experimental Example > Moisturizing activity and hair growth promoting activity experiment

Experimental Example 1 Moisturizing Activity Experiment

Experimental Example 1-1 Skin Water Content Measurement Experiment

For clinical experiments on moisturizing activity, an nutrient lotion in an emulsion state was prepared using the ingredients and contents of the following [Table 1].

Ingredients and Contents of Nutritional Lotion number ingredient content
(weight%) One Each extract of <Examples 1 and 2> 2.0 2 Stearic acid 2.0 3 Stearyl alcohol 0.5 4 Glyceryl Stearate 12.0 5 Cetyloctanoate 0.5 6 Tocopheryl acetate 0.3 7 Glyceryl Monostearate 1.0 8 Decyl cocoate 0.1 9 Hydrogenated Oil 0.5 10 Disodium ID 0.02 11 Caprylic / capric triglyceride 4.0 12 Tee 0.3 13 Butylene glycol 5.0 14 glycerin 3.0 15 Triethanolamine 0.5 16 Purified water Balance

Using the prepared nutrient lotion, the lotion was applied twice a day for 4 weeks to 30 adult men and women in their 30s and 40s who are considered to be dry skin.

As a nutritional lotion of the comparative example, a nutritional lotion containing no extract of the above example but purified water was used.

After 4 weeks, the moisture content (the lower the worsening the dry skin symptoms) is measured by Corneometer (C + K electronic GmbH. Germany) (Corneometer CM825, C + K electronic GmbH. Germany). Table 2].

Moisture content division 0 parking 4 weeks Example 1 36.17 ± 11.76 41.64 ± 8.62 * Example 2 37.18 ± 9.73 40.83 ± 9.52 * Comparative example 36.92 ± 10.29 37.52 ± 12.36 * p <0.05

Experimental Example 1-2 Sensory Evaluation Experiment

At the end of the four weeks of the experiment, it was investigated whether the moisturizing effect in the form of a questionnaire for the test participants are shown in the following [Table 3].

Sensory evaluation results division Very good Improvement No change worse Example 1 23 4 3 0 Example 2 19 7 3 One Comparative example 3 4 19 4

Experimental Example 2 Hair Growth Promoting Activity Experiment

Experimental Example 1 Experiment Inhibitory Effect of 5α - Reductase

In order to determine the inhibitory efficacy of the kinase 5α- reductase in each embodiment the extract, obtained from the liver of rats 5α- reductase kinase and radiolabeled testosterone ₍₃ H-Testosterone) phosphate buffer (50mM Na ₂ HPO containing ₄ (pH 6.6), 25 mM KCl, 500 mM NADPH) were added at a concentration of 1 μg / ml for the extract of each of the above examples, reacted at 37 ° C. for 15 minutes, and the amount of dihydrotestosterone converted from testosterone was quantified. The activity of the reductase is expressed as a percentage.

Activity inhibition rate for 5α-reductase = 100 (A-B / A)

A: conversion rate of testosterone from the untreated group to dihydrotestosterone

B: conversion rate of testosterone to dihydrotestosterone in the treated group

Inhibition of activity against 5α-reductase division % Inhibition Example 1 63.2 Example 2 54.3

Experimental Example 2-2 Sensory Evaluation Experiment

For the sensory evaluation experiment on the hair growth promoting activity, the shampoo was prepared with the ingredients and contents of the following [Table 4].

Ingredients and content of shampoo number ingredient content
(weight%) One Each extract of <Examples 1 and 2> 3.0 2 Methyl paraben 0.2 3 Stearyl alcohol 0.5 4 Sodium Lauryl Sulfate 2.0 5 Behenyl alcohol 0.5 6 Carboxyl Vinyl Polymer 0.2 7 incense 1.0 8 Set trimethylammonium chloride 1.0 9 Purified water Balance

The prepared shampoo was used once daily for four weeks against 30 adult men and women in their 30s and 40s who are considered to have hair loss.

As the shampoo of the comparative example, a shampoo containing no purified extract of the above example but purified water was used.

At the end of the four-week experiment, the results of the questionnaire survey were examined to determine whether the hair loss prevention and hair growth promoting effects were shown in the following [Table 5].

Sensory evaluation results division Very good Improvement No change worse Example 1 16 6 5 3 Example 2 15 5 5 5 Comparative example 2 2 18 8 Very good: When hair loss significantly decreases or hair growth occurs with visual inspection
Improved: When hair loss was obviously reduced by visual inspection
No change: When hair loss symptoms remain unchanged
Exacerbation: Hair loss symptoms worsen with visual inspection

Claims (6)

Skin moisturizing composition comprising camphor extract.
Hair growth promoting or hair loss prevention composition comprising camphor extract.
The method according to claim 1 or 2,
The camphor extract is an extract obtained by extracting leaves, stems, fruits, seeds, flowers or mixtures of camphor trees with water, ethanol or a mixed solvent thereof, or extracts obtained by drying, crushing and crushing the camphor seeds. Composition.
The method according to claim 1 or 2,
The composition is characterized in that the hair cosmetic composition or skin cosmetic composition.
The method of claim 2,
Said composition is a shampoo composition.
The method according to claim 1 or 2,
Wherein said composition is a soap composition.