KR20090029503A - Cosmetic compositions comprising extract from mallotusjaponicus for a pimpled skin - Google Patents

Abstract

A cosmetic composition for improving the acne skin including Mallotus japonicus is provided to hinder the growth of Propionibacterium acnes which is a main factor germ of pimple and to prevent the side effects. A cosmetic composition for improving the acne skin comprises Mallotus japonicus extracts of 0.1% or 10 weight %. The Mallotus japonicus extract is obtained by classifying Mallotus japonicus to stem, skin and leaves, reflux extracting them at room temperature for 2 hours or reflux extracting them at 50°C for 2 hours, and filtering and decompression-concentrating them.

Description

Cosmetic composition for acne skin containing Yeok wood extract {Cosmetic Compositions Comprising Extract from Mallotusjaponicus for a pimpled skin}

The present invention relates to a cosmetic composition for acne skin containing the extract of Yekwood, and more particularly, natural substances having a growth inhibitory ability of propionibacterium acnes, which is the main causative agent of acne, and having no side effects even for long-term use. Extracts made from the Euphorbiaceae plant, Mellotus japonicus, especially tree trees and leaf blood, are specific for Propionibacterium acnes, the main cause of acne. It is an antibacterial activity, using a cosmetic composition for acne skin extract of the Yeokjeok extract, water-soluble skins, viscosity and hardness control agents, UV absorbers, pigments, moisturizers, cleaning agents, preservatives or mixtures of electrical substances, etc. It is characterized by manufacturing, and relates to a cosmetic composition effective for acne .

Acne refers to chronic, intractable and inflammatory skin diseases that occur in hair follicles and sebaceous glands. The causes of acne are divided into various types, including increased sebum secretion, acne bacteria growth, and inflammatory reactions. Depending on the symptoms of acne, the causes of multiple pathways can be complex.

In other words, estrogen, a sex hormone that is increased after puberty, is different from the epidermis of sebum and is well oxidized and is used as an energy source of acne bacteria, so sebum increases excessively increases acne secretion and can cause hair follicle narrowing. . The lipid composition of sebum is also thought to be the biggest factor that can cause skin disease.

Acne bacteria are also anaerobic bacteria that do not multiply in the open hair follicles. In other words, as sebum increases and keratinization of hair follicles progresses, the entrance of the hair follicles is blocked, resulting in acne, an early lesion of acne, and excessive proliferation of acne bacteria.

Increased acne bacteria metabolize the lipids of sebum to produce various fatty acids that are stimulants, and acne bacteria are recognized as antigens and stimulate the body's immune response to cause inflammatory reactions. This causes papules and inflammatory acne lesions, and when deteriorated, the follicle wall is destroyed and tissues are damaged, such as cysts and pustules.

Cosmetics are mainly soap, medicated soap, and abrasive cleanser, which is a concept of healing acne by removing hair follicle narrowing through skin peeling. In addition, the alcohol component of astrigent also exfoliates the skin and disinfects the acne. There are also cosmetics containing resorcinol, sulfur, salicylic acid and benzoyl peroxide. However, these raw materials have a lot of side effects and limitations such as skin irritation due to the limitation of the use concentration.

In addition, antibiotics such as erythromycine for the removal of acne bacteria, anti-inflamation ingredients for inflammation treatment, and hormone preparations for sebum control are used, but these are mainly ingredients in the pharmaceutical domain.

The natural acne products studied so far have been developed with a focus on only one of the various mechanisms of acne described above, so the effects are negligible, recurring, and no preventive concept exists. Therefore, the development of such acne cosmetics are currently being made a lot.

The present inventors conducted a lot of research in order to develop a cosmetic that can be improved as well as prevention of acne, as a result, found that Yedeok wood is effective in the improvement and prevention of acne, and completed the present invention.

Therefore, the present invention has been made to solve the above problems, the object is to provide a cosmetic composition for acne skin containing Yeok wood extract, which is effective in preventing and improving acne containing yeast tree extract and fractions. .

According to a feature of the present invention for achieving the above object, in the acne inhibitory composition, a cosmetic composition for acne skin comprising a Yeok wood extract, characterized in that it contains a wood, bark or leaf extract to provide.

At this time, according to an additional feature of the present invention, it is preferable that the neck or leaf portion of the Yeokdeok tree includes an extract extracted with n-Hexane, CHCl ₃ or EtOAc solvent and the fractions sequentially extracted using the solvent.

In addition, according to an additional feature of the present invention, the cosmetic composition for acne skin is a flexible cosmetic (skin), astringent cosmetics, nourishing cosmetics (lotion), nutrition cream, massage cream, face wash, essence, pack, skin adhesive patch, It is preferably composed of a skin adhesive gel, powder, or a mixture of soaps.

In addition, according to an additional feature of the present invention, it is preferable that the yeast extract contains 0.1 to 10% by weight based on the total weight of the composition as an active ingredient.

Anti-acne cosmetic composition containing the wood extract of the present invention is very effective in the improvement and prevention of acne due to the excellent antibacterial effect on the acne bacteria of the wood.

Yeokdeok extract in the present invention can be used as an active ingredient of the anti-acne composition, preferably can be used as a cosmetic composition. The anti-acne composition comprises 0.1% to 10% by weight of elder tree extract.

Yedeok tree is harmless to the human body since it is used with various herbs since ancient times, and does not cause side effects from long-term use. Cosmetic compositions comprising yeast extracts include those having a soft cosmetic, skin, nourishing cream, massage cream, essences, packs, soaps, shampoos, skin patch or skin adhesive gal.

In order to achieve the object of the composition, the present invention provides an anti-acne composition comprising a cherry tree extract.

Hereinafter, the present invention will be described in detail.

 The present inventors studied various plant extracts in order to search for a substance for preventing acne, and as a result, found a virtuous tree extract with strong antibacterial activity against anti acne among various natural products, and completed the present invention.

 Yeokderak extract included as an active ingredient in the cosmetic composition of the present invention is an extract made by Euphorbia (Mallotus japonicus), in particular, the tree blood (Euphorbiaceae) plant, Yeokdong tree is known as Yaodong (野It is a deciduous arborescent called 적) or red oak tree (赤 芽 柏) and grows in the foothills and valleys of southern Korea. The height is 10m, but it is usually shrub. Yekwood is commonly used as a bark for gastric ulcers, gastritis and liver function.

 Yeokdeok extract of the present invention is classified into wood, bark, leaf, after the sample was extracted with reflux for 2 hours at room temperature with 95% ethyl alcohol, and sample refluxed twice for 2 hours at 50 ℃. Filtration concentrated under reduced pressure.

 Yekderak extract obtained as described above is very effective in anti-acne cosmetic composition because the antibacterial activity against acne bacteria is very high. Accordingly, the present invention relates to an anti-acne cosmetic composition containing Yeok wood extract that is effective in the prevention and improvement of acne.

 The content of Yeokja extract contained in the cosmetic composition is preferably 0.1% to 10% by weight, more preferably 0.1 to 5% by weight. When the content is less than 0.1% by weight, the antimicrobial effect is insignificant, and when the content is more than 10% by weight, there is a problem in that the effect according to the amount used decreases.

 The cosmetic composition may be applied and blended with the usual ingredients, such as oil, water, surfactants, moisturizers, lower alcohols, mid-weight agents, chelating agents, colorants, fragrances, etc., as necessary.

 In addition, the cosmetic composition is used for the skin, supple cosmetics (skin), astringent cosmetics, nourishing cosmetics (lotion), nutrition cream, massage cream, essence, pack, skin adhesive patch, skin adhesive gel, powder, soap, It may be prepared in a conventional cosmetic form such as suspension, emulsion, spray or cosmetic.

Hereinafter, preferred examples are provided to help understanding of the present invention.

Attached Figure 1 is a view showing a process for preparing each fraction of the wood, leaf portion of Yeok wood of the present invention, Figure 2 shows the results of the antimicrobial activity against acne bacteria of Yeok wood, leaf part according to the present invention One sample is shown, and FIGS. 3A to 3B show samples showing the results of the MIC measurement method for antimicrobial activity against P. acnes and S. epidermidis bacteria of each fraction used in FIG. 2.

However, the following examples are provided only to more easily understand the present invention, and the present invention is not limited to the following examples.

EXAMPLE

Example 1. Preparation and antimicrobial activity of the primary extract of Yeokduk extract

Yedeok tree (Bioland, Korea) was divided into wood, bark and leaves and used as a sample.

Methanol and ethanol were used as the extraction solvent, and 12 kinds of extracts were prepared as shown in Table 1 by using a room temperature extraction method and a warm extraction method.

Room temperature extraction was used by immersing the sample in a solvent twice for 72 hours after filtration and concentrated. For heating extraction, the sample was extracted by dipping twice in a solvent at 50 ° C. for 2 hours and then concentrated after filtration.

In order to measure the anti-inflammatory activity of each extract, the penicillin-sensitive strain (S.epidermidis) and acne (P.acnes) were selected and the final bacterial concentration in the MH (Mueller Hinton broth) medium was 10 ⁵ CFU. Inoculated to / ml. Each strain inoculated was incubated for 48 hours at 32 ℃ treated with each extract of 0.9% concentration, and the growth and specific growth of the bacteria were visually observed.

The antimicrobial activities for this study are shown in Tables 1 and 2.

[Table 1] Extraction Conditions of Each Yeok Tree Extract

extract part Solvent Condition Temperature condition One  xylem Methanol Room temperature 2 Gaon 3 Alcohol Ethanol Room temperature 4 Gaon 5   fell Methanol Room temperature 6 Gaon 7 Alcohol Ethanol Room temperature 8 Gaon 9   leaf Methanol Room temperature 10 Gaon 11 Alcohol Ethanol Room temperature 12 Gaon

[Table 2] Antimicrobial Activities of Yeok Tree Extracts

Antimicrobial Activity of Yeok Tree Extract (0.9%) extract part S. epidermidis P.acnes One   xylem + ++ 2 - ++ 3 + +++ 4 +++ +++ 5   fell + ++ 6 + ++ 7 + ++ 8 ++ ++ 9   Leaf ++ ++ 10 ++ + 11 +++ +++ 12 + ++

-: Does not inhibit the growth of bacteria

+: grow to 100 or more colony

++: grow 1 to 100 colony

+++: 100% inhibition of colony growth

Example 2 Determination of Minimum Inhibitor Concentration (MIC)

In order to measure the anti-inflammatory action of the 4 and 11 excellent antibacterial activity of the extract of Yekwood extract extracted in Example 1, penicillin-sensitive strains (S.epidermidis) and representative strains of acne (P.acnes) by selecting MH ( Mueller Hinton broth) was inoculated to a final bacterial concentration of 10 ⁵ CFU / ㎖. After treatment with Yeokdeok extract No. 4 and 11 by microdilution method and incubated for 48 hours at 32 ℃, the growth and non-growth of bacteria were visually observed to determine the minimum concentration at which growth was inhibited to the minimum inhibitory concentration (MIC). Was determined, and the results are shown in Table 3 below.

TABLE 3

Antibacterial Activities of Yeok-Duk Extract by Concentration

Antibacterial Activities of Fractions of Yeok-mok (4) and Yeok-mok Leaves (11) extract density(%) S. epidermidis P.acnes  Yert Wood Extract (4) 0.1 - - 0.3 ++ +++ 0.5 +++ +++ 0.9 +++ +++  Yeok Tree Leaf Extract (11) 0.1 - - 0.3 ++ +++ 0.5 +++ +++ 0.9 +++ +++

-: Does not inhibit the growth of bacteria

+: grow to 100 or more colony

++: grow 1 to 100 colony

+++: 100% inhibition of colony growth

As a result of Table 3, it was confirmed that MIC of S.epidermidis and 0.5 M of P. acnes were 0.3%, respectively.

According to the accompanying drawings of FIG. 3A, it can be seen that acne-associated bacteria are activated in the P. acnes negative sample. At this time, it can be seen that the active acne bacteria growth was inhibited 100% when 0.3% or 0.9% of the extracts of the elder tree 4 or the leaf 11 of Table 3 were administered.

On the other hand, Figure 3b is a state in which the acne-related bacteria as shown in Figure 3a is shown in the sample of S.epidermidis negative.

When the 0.3% administration of the extract of Yeok wood (4) or leaf 11 of Table 3 to the sample of each of the above can be seen that the above and the active acne bacteria grown to 100 or less, wherein the extract It can be seen that when 0.9% is administered, it is 100% inhibited as in the sample of P.acnes.

Example 3 Preparation and Antimicrobial Activity of Fractions of Yeok Tree (4) and Yeok Tree Leaves (11)

The fractions were prepared after sequentially extracting No. 4 and No. 11, which were excellent in the antimicrobial activity, of the Yeokduk extracts extracted in Examples 1 and 2 with each solvent n-Hexane, CHCl ₃ , EtOAc, and Residue.

That is, as shown in the accompanying FIG. 1, each fraction can be prepared by dividing the yeok tree of the present invention into a neck and a leaf, and the neck warms the spirit to prepare a neck extract, and then extracts each solvent n-hexane (4 -1), CHCl ₃ (4-2), EtOAc (4-3), Residue (4-4) after the sequential extraction to prepare the fractions, the leaves were prepared by extracting the ethanol at room temperature extract, each extract was extracted Fractions were prepared after successive extraction with solvent n-hexane (11-1), CHCl ₃ (11-2), EtOAc (11-3), and Residue (11-4).

Selected penicillin-sensitive strains (S.epidermidis) and representative strains of acne (P.acnes) in order to measure the anti-inflammatory action of each oak tree neck (4), the elder tree leaf (11) of the extracts fractionated as described above MH (Mueller Hinton broth) medium was inoculated so that the final bacterial concentration is 10 ⁵ CFU / ㎖. Each strain inoculated was treated with each fraction of 0.9% concentration and incubated for 48 hours at 32 ℃, the growth and specific growth of the bacteria were visually observed. Irgasan, an anti-acne drug commonly used as a control, was used.

A detailed description of this study is shown in Table 4.

TABLE 4

Antibacterial activity of fractions of Yeok-mok wood (4), Yeok-mok leaves (11);

Antibacterial Activity (0.9%) of Fractions of Yeok-mok (4) and Yeok-mok Leaf (11) S.epidermidis P.acnes  Yert Wood Extract (4) n-hexane fraction 4-1 + +++ CHCl ₃ Fraction 4-2 +++ +++ EtOAc fraction 4-3 + +++ Residue 4-4 - +  Yeok Tree Leaf Extract (11) n-hexane fraction 11-1 - +++ CHCl3 Fraction 11-2 ++ +++ EtOAc fraction 11-3 +++ +++ Residue 11-4 - + Irgasan (0.05%) +++ +++

-: Does not inhibit the growth of bacteria

+: grow to 100 or more colony

++: grow 1 to 100 colony

+++: 100% inhibition of colony growth

The Yeok wood neck extract (4) or leaf extract (11) can be seen if there is an antimicrobial activity against P. acnes, S.epidermidis bacteria as shown in FIG.

The extract fractionated through the Yeokdeok wood (4), leaf 11 as described above is the softening longevity (skin), astringent longevity, nourishing longevity (lotion), nutrition cream, massage cream, face wash, essence, pack, skin adhesive A patch, skin adhesive gel, powder, or a mixture of soaps can be prepared in a cosmetic composition for acne skin comprising a wood extract according to the present invention, which is a common woodwood extract (wood) in the composition of a cosmetic composition for acne skin 4) Or it may be made by configuring a certain ratio of the leaf portion extract (11).

Hereinafter, as an example of the formulation of the present invention, supple cosmetics (skin), nourishing cosmetics (lotion), essences, nutrition creams, massage creams, packs, sun creams (cleansing foams), soaps, but the cosmetic composition of the present invention Formulations including are not limited thereto.

Formulation 1.Flexible Lotion (Skin)

In order to produce a flexible skin lotion for acne skin containing the yeast extract of the present invention can be combined according to the preparation method in the conventional cosmetic field as shown in Table 5 below.

TABLE 5

ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% 1,3-butylene glycol 3.0 glycerin 5.0 Polyoxyethylene (60) hardening castor oil 0.2 ethanol 8.0 Citric acid 0.02 Sodium citrate 0.06 antiseptic a very small amount Spices a very small amount Purified water To 100

Formulation Example 2. Nutritional Lotion (Lotion)

In order to produce a nourishing lotion for acne skin containing the yeast extract of the present invention can be combined according to the preparation method in the conventional cosmetic field as shown in Table 6 below.

TABLE 6

ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% 1,3-butylene glycol 8.0 glycerin 5.0 Squalane 10.0 Monooleic acid polyoxyethylene sorbitan (6E.0) 2.0 Triethanol amine 1.5 Glyceryl Stearate 0.5 Stearyl glycyrrhetinate 0.2 Carboxy Vinyl Polymer 0.1 Arginine 0.1 antiseptic a very small amount Spices a very small amount Purified water To 100

Formulation Example 3. Essence

In order to prepare an essence for acne skin including the extract of the present invention, it can be blended as described in Table 7 and prepared according to the manufacturing method in the conventional cosmetic field.

TABLE 7

ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% Cytostolol 1.7 Polyglyceryl 2-oleate 1.5 Ceramide 0.7 Ceteares-4 1.2 cholesterol 1.5 Dicetylphosphate 0.4 Concentrated glycerin 5.0 Carboxy Vinyl Polymer 0.2 Xanthan Gum 0.2 antiseptic a very small amount Spices a very small amount Purified water To 100

Formulation Example 4 Facial Cleanser (Cleansing Foam)

To prepare acne skin cleansing agent (cleansing foam) comprising the extract of Yekwood of the present invention can be prepared according to the manufacturing method in the conventional cosmetic field by combining as described in Table 8.

TABLE 8

ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% N-acyl glutamate 20.0 glycerin 10.0 PEG-400 15.0 Propylene glycol 10.0 POE (15) oleyl alcohol ether 3.0 Lauric derivatives 2.0 Methyl paraben 0.2 EDTA-4Na 0.03 Spices 0.2 Purified water To 100

Formulation Example 5 Preparation of Nutritional Cream

To prepare a nourishing cream for acne skin containing the prunus extract of the present invention is prepared according to the manufacturing method in the conventional cosmetic field as shown in Table 9.

TABLE 9

Ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% vaseline 7.0 Liquid paraffin 10.0 Beeswax 2.0 Polysorbate 60 2.5 Sorbitan sesquioleate 1.5 Squalane 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Xanthan Gum 0.5 Tocophenyl Acetate 0.1 Incense, preservative a very small amount Purified water To 100

      Formulation Example 6 Massage Cream Preparation

In order to prepare a massage cream for acne skin containing the wood extract of the present invention is prepared according to the manufacturing method in the conventional cosmetic field as shown in Table 10 below.

TABLE 10

Ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2 .0 Tocophenyl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Xanthan Gum 0.5 Incense, preservative a very small amount Purified water To 100

      Formulation Example 7 Pack Preparation

It is prepared according to the manufacturing method in the general cosmetic field as described in Table 11 to prepare a pack for acne skin containing the prunus extract of the present invention.

TABLE 11

Ingredient Content (% by weight) Yeok Tree Extract 0.1 to 10% Propylene glycol 2.0 glycerin 4.0 Polyvinyl alcohol 10.0 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Incense, preservative a very small amount Purified water To 100

The present invention is not limited to the embodiments described above, and various modifications and changes can be made by those skilled in the art, which are included in the spirit and scope of the present invention as defined in the appended claims.

1 is a view showing a process for producing each fraction of the neck, leaf portion of Yedeok tree of the present invention

Figure 2 is a sample showing the results of the antimicrobial activity against the pimples of Yeok wood, leaf fraction according to the present invention

Figure 3a is a sample showing the antimicrobial activity of the P. acnes bacteria of each fraction used in Figure 2 by the MIC measurement method

Figure 3b is a sample showing the antimicrobial activity of the S.epidermidis bacteria of each fraction used in Figure 2 by MIC measurement method

Claims (4)

In acne suppression composition, A cosmetic composition for acne skin comprising a wood extract, characterized in that it contains a wood, bark or leaf extract. The method of claim 1, The neck or leaf portion of the Yekwood tree is an acne skin cosmetic composition comprising an extract extracted with n-Hexane, CHCl ₃ or EtOAc solvent and a fraction extracted sequentially using the solvent. The method according to claim 1 or 2, The cosmetic composition for acne skin is a flexible cosmetic (skin), astringent makeup, nourishing cosmetic (lotion), nourishing cream, massage cream, face wash, essence, pack, skin adhesive patch, skin adhesive gel, powder, or a mixture of soap Cosmetic composition for acne skin comprising a prunus extract, characterized in that. The method according to claim 1 or 2, Acne skin cosmetic composition comprising a yok wood extract, characterized in that the Yeok wood extract contains 0.1 to 10% by weight based on the total weight of the composition as an active ingredient.

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