JPH107582A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin lotion, having agingpreventing, antiinflammatory and skin lightening effects, antimicrobial actions, exhibiting cleaning actions on skin, excellent in stability and safety. SOLUTION: This skin lotion comprises one or more selected from an extract of Pleione sp., an extract of Cremastra appendiculata Makino, an extract of Pleione bulbocodioides and an extract of Tulipa edulis Baker. These extracts have aging-preventing, anti-inflammatroy and skin lightening effects by the elimination of the source of active oxygen.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has an excellent elimination effect of reactive oxygen species, and can exert both antibacterial activity and whitening effect.
Useful for improvement, cleansing, prevention and improvement of pigmentation symptoms,
The present invention relates to an external preparation for skin having excellent stability and safety. More specifically, the extract of the herbal medicine "Yamajugi" or its base plant, Saihyran ( Crematra appendiculata Maki)
The present invention relates to an external preparation for skin comprising one or more extracts of each of the following extracts: no), doxanlan ( Pleione bulbocodioides ), or amana ( Tulipa edulis Baker).

[0002]

2. Description of the Related Art Skin is exposed to various stresses existing in the environment, such as heat, ultraviolet rays, and various chemical substances. As a result, inflammatory reactions such as erythema and edema, allergic reactions, and blackening due to melanin production occur on the skin. As a result of being subjected to the stress for a long period of time, wrinkles and wrinkles of the skin occur, and elasticity decreases. It has been revealed that such aging symptoms progress. In addition, various indigenous bacteria are present on the skin, and they assimilate sebum and waste products and abnormally proliferate and change the flora, which is one of the causes of acne vulgaris and dandruff It is also known that there is.

[0003] Accordingly, the search for effective ingredients for preventing the above-mentioned inflammation and the like, for preventing the skin from being blackened or aged, and for sterilizing and cleaning the skin has been conducted. Offering has been attempted. For example, anti-inflammatory agents include β-glycyrrhetinic acid, glycyrrhizic acid, salts and derivatives thereof, allantoin and its derivatives, azulene, ε-aminocaproic acid, hydrocortisone, and the like. For alleviation of allergic symptoms, diphenhydramine hydrochloride, chlore maleate. Antihistamines such as pheniramine are used. As whitening agents, ascorbic acid and its derivatives, kojic acid and its derivatives, hydroquinone derivatives such as arbutin, etc., and as bactericidal and cleansing agents for skin, hinokitiol, zinc pyrithione, photosensitizer, etc. Is used. In recent years, aging of skin due to oxidative stress has been highlighted, and elimination agents for active oxygen species such as vitamin E and superoxide dismutase have been added.

[0004] However, many of the above-mentioned components which have been conventionally used are unstable to light and heat, etc., and their actions and effects are insufficient. In order to obtain, it was necessary to blend a considerably large amount.
Furthermore, there are few ingredients that can exhibit all effects together with anti-aging of skin, whitening and sterilization and cleansing of skin,
In order to exert these effects evenly, it is necessary to use various types of components in combination, and depending on the components used in combination,
The respective stability and action may be reduced.

[0005]

DISCLOSURE OF THE INVENTION The present invention aims to solve the above-mentioned problems, and contains only a small amount and a small number of active ingredients, and has the effects of preventing aging, whitening and disinfecting and purifying the skin. An object of the present invention is to provide an external preparation for skin having excellent stability and safety.

[0006]

Various studies have been made to solve the above-mentioned problems. As a result, an extract of Yamajugi used as a crude drug, and its base plant, Cyhailan ( Cremastr.)
a appendiculata Makino), Doxanlan ( Pleione bu )
lbocodioides ) and Amana ( Tulipa edulis Baker) extracts have strong anti-aging, whitening and antibacterial effects, and when these are added to the skin external preparation base,
The present inventors have found that the above-mentioned actions and effects are not affected by the base component and are excellent in storage stability, and have completed the present invention.

[0007] Therefore, in the present invention, a crude drug, an extract of San Ji-Gu, or Saihyran ( Cremastra appendicul)
ata Makino extract, Pleione bulboc
odioides ) and Amana ( Tulipa edulis Bake)
One or more selected from the extracts of r) are contained in the base for external preparation for skin.

[0008] As an extraction solvent, in addition to water, methanol,
One or more of alcohols such as ethanol, propanol, isopropanol, 1,3-butylene glycol, and propylene glycol, and highly polar organic solvents such as ethyl acetate and acetone can be used.

The herbal medicine Yamajigi used for the extraction is obtained by drying the bulb of Saihailan or the temporary bulb of Doxanlan or the bulb of Amana. In addition to these, sites such as flowers, stems, leaves, and the like, and the whole plant can be used for extraction. The extraction may be carried out as it is on a live plant, or may be carried out after processing such as shredding, drying and pulverization.

The extract can be added to the external preparation base as it is, but it can be diluted with a solvent such as water or alcohol,
The concentrated or dried product may be dissolved again in a polar solvent such as alcohol, or may be added after performing a treatment such as decolorization and deodorization. As a compounding amount in the external preparation for skin, a crude extract obtained by extracting with a solvent of an amount capable of sufficiently immersing Yamajigi or its base plant, in a state of 0.001 to 10.0% by weight
It is preferable to set the degree.

[0011] In the present invention, in addition to the extract of Yamajiku and others, other active oxygen species scavengers, anti-inflammatory agents, whitening agents,
In addition to bactericides, general external preparations such as oils, humectants, ultraviolet absorbers, fragrances, and preservatives and raw materials for cosmetics can be contained.

[0012]

The external preparation for skin according to the present invention has an excellent antioxidant action of the skin based on an excellent elimination action of active oxygen species and an anti-inflammatory action, a whitening action based on a tyrosinase inhibitory action, and a bactericidal and antibacterial action.

Therefore, the external preparation for skin according to the present invention can improve and prevent aging symptoms of the skin mainly caused by oxidative stress, treat and prevent inflammation in the skin such as rough skin, spots, freckles, etc. It has an excellent action and effect in the improvement and prevention of pigmentation and blackening due to sunburn, etc., and in the mitigation and prevention of symptoms caused by abnormalities of indigenous skin bacteria such as acne vulgaris and dandruff.

In addition, due to excellent sterilization and antibacterial effects, contamination by microorganisms such as bacteria and fungi can be prevented well, and the stability of the preparation can be improved.

[0015]

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a lotion, an emulsion,
It can be provided as a skin external preparation in the form of a gel, cream, ointment or the like. Also, skin cosmetics such as lotions, emulsions and creams, makeup base lotions, makeup base creams, liquid or creamy or ointment type foundations, makeup cosmetics such as eye color and teak color, shampoo, rinse, Hair cosmetics such as hair treatments, hand creams,
They can also be provided as body cosmetics such as leg creams and body lotions.

[0016]

EXAMPLES The present invention will be described in more detail with reference to Examples.

[Example 1] Lotion for skin (1) Ethanol 10.0 (wt%) (2) Hydroxyethylcellulose 1.0 (3) Ethanol extract of whole plant of Saihailan 5.0 (4) Purified water 84 0.0 Production method: (1) to (4) are mixed and made uniform.

Example 2 Emulsion for skin (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid paraffin 7.0 (5) Polyoxy Ethylene (10E.O.) monooleic acid 1.5 ester (6) Tocopherol acetate 5.0 (7) Glycerin 5.0 (8) Methyl parahydroxybenzoate 0.1 (9) Triethanolamine 1.0 (10 ) Purified water 71.7 (11) Methanol extract of whole plant of Saihailan 2.0 (12) Ethyl acetate extract of whole plant of doxanlan 2.0 Manufacturing method: Mix and heat oil phase components (1) to (6) Dissolve uniformly and keep at 70 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and heated to be uniform, and the temperature is set to 70 ° C. The oil phase component is gradually added to the aqueous phase component while stirring to emulsify, and after cooling, (11) and (12) are added at 40 ° C.

Example 3 Skin Gel (1) Dipropylene glycol 10.0 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Potassium hydroxide 0.1 (4) Methyl paraoxybenzoate 0.1 (5) Purified water 84.3 (6) Ascorbic acid phosphoric acid ester magnesium salt 4.0 (7) Ethanol solution of ethyl acetate extract from Yamajiki 1.0 Production method: (5) is homogeneous with (2) After dissolving in (1), (4) is dissolved and added to (1), and then (3) is added to thicken, and (6), (7)
Is added.

Example 4 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 27.5 (5) Glyceryl fatty acid ester 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20E.O.) sorbitan 5.0 Monolaurate (8) Propylene glycol 5.0 (9) Paraoxybenzoic acid Methyl 0.1 (10) Purified water 30.4 (11) Retinol palmitate 1.0 (12) 50% by weight of Saihyran whole plant Propylene 3.0 Glycol extract (13) 50% by weight of Amana whole plant , 3-butylene glycol 3.0 extract Production method: Mix and dissolve the oil phase components (1) to (7) and heat to 75 ° C. On the other hand, the aqueous phase components (8) to (10) are mixed and dissolved, and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified by a homomixer. After cooling, (11) to (13) are added at 40 ° C.

Example 5 Oil-in-water emulsion ointment (1) White petrolatum 25.0 (% by weight) (2) Stearyl alcohol 25.0 (3) Glycerin 12.0 (4) Sodium lauryl sulfate 1.0 (5) Methyl paraoxybenzoate 0.1 (6) Purified water 33.9 (7) Retinoic acid 0.5 (8) 50% by weight propanol 1.5 extract of Saihyran whole plant (9) 60 of Doxanlan whole plant 0.5% by weight ethanol extract 0.5 (10) 60% by weight ethanol extract of amana whole plant 0.5 Production method: Mix and dissolve the oil phase components of (1) to (4) to make uniform,
Heat to 75 ° C. On the other hand, the aqueous phase components (5) and (6) were mixed and dissolved, heated to 75 ° C., added with the oil phase component and emulsified, cooled, and then cooled to 40 ° C. at (7) to (10). ) Is added and mixed.

Example 6 Lotion (1) Ethanol 10.0 (% by weight) (2) 1,3-butylene glycol 5.0 (3) Ethanol extract of Saihailan flower 0.5 (4) Fragrance 0 1.1 (5) Purified water 84.4 Production method: (1) to (4) are sequentially added to (5) and uniformly mixed and dissolved.

[Example 7] Emollient cream (water-in-oil type) (1) Liquid paraffin 30.0 (% by weight) (2) Microcrystalline wax 2.0 (3) Vaseline 5.0 (4) Diglyceryl geo Leic acid ester 5.0 (5) Sodium L-glutamate 1.6 (6) L-serine 0.4 (7) Propylene glycol 3.0 (8) Methyl parahydroxybenzoate 0.1 (9) Purified water 52. 4 (10) 50% by weight propylene 0.2 glycol extract of doxanlan stem and leaf (11) 1,3-butylene glycol 0.2 extract of amana stem, leaf and flower (12) Fragrance
0.1 Production method: (5) and (6) are dissolved in a part of (9) to 50 ° C., and gradually added to (4) heated to 50 ° C. with stirring. This was previously mixed and dissolved by heating to 70 ° C. (1)
(7) and (8) are dissolved in the remainder of (9), heated to 70 ° C., added with stirring, and emulsified by a homomixer. After cooling, at 40 ° C (10)-(1
2) Add and mix.

Example 8 Makeup Base Cream (1) Stearic acid 12.00 (% by weight) (2) Cetanol 2.00 (3) Glyceryl tri-2-ethylhexanoate 2.50 (4) Self-emulsification Type glyceryl monostearate 2.00 (5) Propylene glycol 10.00 (6) Potassium hydroxide 0.30 (7) Methyl paraoxybenzoate 0.10 (8) Purified water 69.49 (9) Titanium dioxide 1 .00 (10) Bengala 0.10 (11) Yellow iron oxide 0.40 (12) Fragrance 0.10 (13) Ethanol extract of Yamajiku 0.01 Production method: Oil phase components of (1) to (4) And heat to 75 ° C. to make uniform. On the other hand, mix the aqueous phase components (5) to (8)
The mixture is heated and dissolved to make the mixture uniform, and the pigments (9) to (11) are added to the mixture and uniformly dispersed by a homomixer. The oil phase component is added to the water phase component, emulsified by a homomixer, cooled, and (12) and (13) are added and mixed at 40 ° C.

Example 9 Liquid Foundation (1) Stearic acid 2.00 (% by weight) (2) Squalane 5.00 (3) Octyldodecyl myristate 5.00 (4) Cetanol 1.00 (5) Polyglyceryl Monoisopalmitate 9.00 (6) 1,3-butylene glycol 6.00 (7) Potassium hydroxide 0.10 (8) Methyl parahydroxybenzoate 0.10 (9) Purified water 53.35 (10) Titanium oxide 9.00 (11) Talc 7.40 (12) Bengala 0.50 (13) Yellow iron oxide 1.10 (14) Black iron oxide 0.10 (15) Fragrance 0.15 (16) 1,3-butylene glycol extract 0.20 Production method: Mix the oil phase components (1) to (5) and heat to 75 ° C. to make uniform. On the other hand, the aqueous phase components of (6) to (9) were mixed and
The mixture is heated and dissolved to make the mixture uniform, and the pigments (10) to (14) are added to the mixture and uniformly dispersed by a homomixer. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and (15) and (16) are added and mixed at 40 ° C.

Example 10 Shampoo (1) Sodium alkyl ether sulfate 18.000 (% by weight) (2) Coconut oil fatty acid diethanolamide 2.000 (3) Propylene glycol 2.000 (4) Ethanol of whole plant of Saihyran Extract 2.000 (5) Yellow No. 4 0.001 (6) Fragrance 0.200 (7) Purified water 75.799 Production method: (1) to (6) are sequentially added to (7) to make it uniform .

Example 11 Hair rinse (1) Cetanol 3.000 (% by weight) (2) Stearyltrimethylammonium chloride 0.700 (3) Glycerin 3.000 (4) N-cocoyl-L-arginine ethyl ester 0.100 -DL-pyrrolidonecarboxylate (5) Green No. 3 0.002 (6) Purified water 90.098 (7) Fragrance 0.100 (8) Glycerin extract of whole doxanlan 1.500 (9) Glycerin extract of Amana whole plant 1.500 Production method: Mix and dissolve the aqueous phase components (3) to (6) and heat to 70 ° C. On the other hand, the oil phase components (1) and (2) were mixed and dissolved,
Heat to 0 ° C. The oil phase is gradually added to the aqueous phase while stirring, pre-emulsified, homogenized by a homomixer, cooled, and (7) to (9) are added and mixed at 40 ° C.

Example 12 Liquid Body Cleanser (1) N-Lauroyl-L-Glutamate Triethanol 20.0 (% by weight) Amine (30.0% by weight aqueous solution) (2) N-Laurylmethyltaurine Sodium 10 0.0 (30.0% by weight aqueous solution) (3) Triethanolamine laurate 10.0 (4) Triethanolamine myristate 10.0 (5) Lauryl imidazolinium betaine 5.0 (6) Lauroyl diethanolamide 5 0.0 (7) Propylene glycol 7.0 (8) Purified water 28.4 (9) Fragrance 0.1 (10) Ethanol extract of whole plant of Saihyran 1.5 (11) Ethanol extract of whole plant of doxanlan 1. 5 (12) Ethanol extract of Amana whole plant 1.5 Production method: The components of (1) to (12) are sequentially added and mixed to make uniform.

Of the above Examples, Examples 1 to 5 were evaluated for their anti-aging effect, skin roughness improvement effect, and whitening effect. At that time, in each example,
Doxanlan and Amana whole plant extract in each extraction solvent,
In addition, Comparative Example 1 to Comparative Example 5 were performed by replacing ethanol solution of the ethyl acetate extract of Yamagigi with ethanol, and evaluation was performed in the same manner.

First, the effect of preventing skin aging was evaluated by evaluating the effect on wrinkling in hairless mice. In the evaluation, five hairless mice were divided into one group, and the examples and the comparative examples were applied to the back once a day for each group, and 50 JL / cm ² / week long-wave ultraviolet light (UVA) was applied.
Irradiation was performed for a week, the occurrence of wrinkles on the back skin of the hairless mouse was observed, and scored according to the criteria shown in Table 1. At this time, a group to which only purified water was applied was used as a control. The results are shown in Table 2 by calculating the average value of each group and showing the relationship with the number of UVA irradiation days.

[Table 1]

Next, the effect of improving skin roughness was evaluated by using 20 female panelists with remarkable skin roughness symptoms as a group, and using the examples and comparative examples twice a day in each group continuously for one month in a blind. After one month, the symptoms of the skin were observed and compared with before the start of use. The skin roughness symptoms were scored according to the criteria shown in Table 3 and the average value of 20 persons was calculated.

[Table 3]

Subsequently, the effect of improving the pigmentation symptom was evaluated by assuming that 20 female panelists having remarkable pigmentation symptoms such as spots and freckles were grouped into one group, and the examples and comparative examples were blinded to each group for 2 days a day. It was used for one month each time, and the state of pigmentation of the skin after one month was observed and compared with that before use. The state of pigmentation was evaluated according to the criteria shown in Table 5, and the average value of 20 persons was calculated. The results are shown in Table 4.

[Table 5]

[0033]

[Table 2] In Table 2, occurrence of deep wrinkles was observed in most of the hairless mice in the control group after 50 weeks. However, in the group to which the examples of the present invention were applied, the occurrence of wrinkles was significantly suppressed in all cases. After 50 weeks, only slight wrinkles or slight wrinkles were observed. In particular, in the group applied with Example 3 to which a solution of the extract of Yamajugi was added, a good wrinkle preventing effect was recognized. On the other hand, in Comparative Example 1 application group, almost no suppression of wrinkles was observed,
Also in Comparative Examples 2 to 5 containing the tocopherol acetate, which is a vitamin having an antiaging effect, no sufficient suppression of wrinkles was observed.

[0034]

[Table 4] Next, Table 4 shows that in the group using the examples of the present invention, favorable improvement of the rough skin symptom was observed in all the groups, and it was shown that the skin condition was recovered to almost satisfactory. On the other hand, in the group using Comparative Example 1, improvement in skin roughness was not so much recognized, and in the groups using Comparative Example 2 to Comparative Example 5, the recovery of the skin condition was insufficient.

In addition, the pigmentation symptom was also favorably improved in the group using the example, and at the end of the use test, slight pigmentation was observed in most of the panelists. On the other hand, in the comparative group, the comparative examples 1 and 2
Almost no improvement was observed in the use group, and in the use groups of Comparative Examples 3 to 5, many panelists still observed moderate pigmentation at the end of the use test.

Subsequently, in Examples 6 to 12,
Antibacterial activity and storage stability were evaluated. In each of the examples, the extract obtained by substituting an extract such as Jin-Yu for each extraction solvent was used as a comparative example, and was evaluated at the same time.

The antibacterial activity was measured using Escherichia coli (Escher
ichia coli), Staphylococcus aureus ( Staphylococcus aur
eus), Pseudomonas aeruginosa (Pseudomonas aeruginosa) 、 Acne fungus
(Propyonibacterium acnes), Black mold (Aspergillus n
iger ) And dandruff (Pityrosporum ovale )
These were used for each Example and Comparative Example, respectively.⁶Pcs / g inoculation
Bacteria at 37 ° C and fungi at 25 ° C for 2 weeks
The number of viable bacteria was counted and evaluated. The result is two weeks later
The number of bacteria is 0 for bacteria and 10 for fungi^ThreePieces/
Table 6 shows the case where the value was equal to or less than g.

The storage stability was evaluated by storing each of the Examples and Comparative Examples at 25 ° C. for 3 months, and observing changes in appearance and deterioration such as discoloration, odor, phase separation and precipitation of contained components. did. Evaluation is "○;good","△; slightly bad",
The results are shown as "x;bad" and are summarized in Table 6.

[0039]

[Table 6] Examples 6 to 12 of the present invention do not contain any preservative or contain only a low concentration, but in Table 6, good antibacterial activity and storage stability were observed for all. . In particular, although not shown in the table, in Examples 10 and 11, which are hair compositions, all the dandruff bacteria were killed after 2 weeks, and it was predicted that the antidandruff effect was high. In contrast, in the comparative examples, Pseudomonas aeruginosa
Antibacterial activity against black mold and dandruff was low, and storage stability was not good.

Next, Examples 6 to 9 and Comparative Examples 6 to
In Comparative Example 9, the presence or absence of discomfort during use was investigated.
Each group consisted of 20 female panelists, and each group was allowed to use each of the examples and comparative examples with a blind. From 30 seconds to 1 minute after application to the skin, stinging pain, burning, and tingling Discomfort such as feeling was evaluated. The evaluation results are "very strong; 5 points", "somewhat strong; 4 points", "clearly; 3 points", "a little; 2 points", "subtle; 1 point", " Not felt; 0 point "is shown as a score. Table 7 shows the average value of 20 persons.

[0041]

[Table 7] In Table 7, in the group using the examples of the present invention, the discomfort felt when applied to the skin was significantly reduced as compared with the corresponding groups using the corresponding comparative examples, and the feel during use was excellent. It is shown.

Subsequently, Example 10 having a high surfactant content was used.
About Example 12 and Comparative Examples 10 to 12, skin irritation was evaluated. 1.0 of each Example and Comparative Example
A 48% by weight aqueous solution was used as a sample, and a 48-hour obstruction sticking test was performed on the back skin using 30 male panelists.
The skin irritation index was determined according to the criterion shown in Table 2, and the average value of 30 persons was determined. The results are shown in Table 9.

[Table 8]

[0043]

[Table 9] In Table 9, high skin irritation index was observed in all Comparative Examples, and particularly, in Comparative Example 12, significant erythema and edema were observed. In contrast, in the examples of the present invention, a remarkable reduction in the skin irritation index was observed.

[0044]

As described above in detail, according to the present invention, it is excellent in the effect of preventing and improving the aging symptoms and inflammation of the skin, in the effect of cleansing and whitening the skin, and has good antibacterial activity, stability and An external preparation for skin excellent in safety was obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification number Office reference number FI Technical display location A61K 7/00 A61K 7/00 W 7/48 7/48

Claims (3)

[Claims] 1. An external preparation for skin comprising an extract of a crude drug "Yamajiku". 2. Saisairan ( Cremastra appendiculat)
a Makino) extract, Pleione bulbocod
ioides ) extract and amana ( Tulipa edulis Bake)
An external preparation for skin, comprising one or more selected from the extracts of r). 3. The external preparation for skin according to claim 1, wherein the external preparation for skin is a cosmetic.