CN114376212A - Health-care granules with effects of maintaining beauty and keeping young and resisting aging and preparation method thereof - Google Patents

Health-care granules with effects of maintaining beauty and keeping young and resisting aging and preparation method thereof Download PDF

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CN114376212A
CN114376212A CN202011133319.3A CN202011133319A CN114376212A CN 114376212 A CN114376212 A CN 114376212A CN 202011133319 A CN202011133319 A CN 202011133319A CN 114376212 A CN114376212 A CN 114376212A
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parts
extract
health
effects
queen bee
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孙天伟
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Yunnan Laodianhuang Food Co ltd
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Yunnan Laodianhuang Food Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/015—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/035—Organic compounds containing oxygen as heteroatom
    • A23L29/04—Fatty acids or derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/37—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention discloses a health-care particle with the effects of maintaining beauty and keeping young and resisting aging and a preparation method thereof, wherein the health-care particle with the effects of maintaining beauty and keeping young and resisting aging comprises the following raw materials in parts by weight: 5-15 parts of grape seed extract, 1-10 parts of queen bee larva powder, 0.5-5 parts of rhodiola rosea extract, 2-6.5 parts of astragalus extract, 1-4 parts of angelica extract, 5-15 parts of deep sea fish collagen peptide, 0.2-3 parts of green tea extract, 0.1-6 parts of vitamin C, 10-120 parts of water-soluble cyclodextrin, 0.2-2 parts of flavoring agent and 0.1-1 part of lubricant. The health-care particle with the functions of maintaining beauty, keeping young and resisting aging has no toxic or side effect, is convenient to eat and carry and store, and has the functions of maintaining beauty, keeping young, delaying aging and enhancing the immune function of a human body after being eaten for a long time.

Description

Health-care granules with effects of maintaining beauty and keeping young and resisting aging and preparation method thereof
Technical Field
The invention relates to the technical field of health-care particles, in particular to health-care particles with effects of maintaining beauty and keeping young and resisting aging and a preparation method thereof.
Background
In recent years, with the economic development and the improvement of living standard of society, people pay more and more attention to resisting aging, beautifying and retaining youth. However, due to the work and the accelerated living articulation of modern people, some people have the appearance and the body form of aging just after the thirties, such as lusterless complexion, tarnished and dark spots, multiple wrinkles and garbled complexion. At present, the clinical treatment method mainly achieves the purposes of prevention and recovery by externally coating medicines or skin care products, but the treatment of exterior and interior diseases cannot be treated, and the problem cannot be fundamentally solved. Therefore, people will need safer health food which is beneficial to health, and the requirements of people on beauty treatment, face care and anti-aging are met by adjusting the body functions.
Disclosure of Invention
The invention aims to overcome the defects and provides health-care granules with the effects of maintaining beauty and keeping young and resisting aging, which are prepared by compounding grape seed extract, queen bee embryo powder, rhodiola root extract, astragalus extract, angelica extract, deep-sea fish collagen peptide, green tea extract, vitamin C, water-soluble cyclodextrin, flavoring agent and lubricant.
In order to achieve the purpose, the invention provides health-care particles with the effects of maintaining beauty, keeping young and resisting aging in a first aspect, which comprise the following raw materials in parts by weight: 5-15 parts of grape seed extract, 1-10 parts of queen bee larva powder, 0.5-5 parts of rhodiola rosea extract, 2-6.5 parts of astragalus extract, 1-4 parts of angelica extract, 5-15 parts of deep sea fish collagen peptide, 0.2-3 parts of green tea extract, 0.1-6 parts of vitamin C, 10-120 parts of water-soluble cyclodextrin, 0.2-2 parts of flavoring agent and 0.1-1 part of lubricant.
By adopting the technical scheme, the health-care particle with the effects of maintaining beauty and keeping young and resisting aging is prepared by compounding grape seed extract, queen bee embryo powder, rhodiola rosea extract, astragalus extract, angelica extract, deep-sea fish collagen peptide, green tea extract, vitamin C, water-soluble cyclodextrin, flavoring agent and lubricant, has no toxic or side effect, is convenient to eat and carry and store, and has the effects of maintaining beauty and keeping young, delaying aging and enhancing the immune function of a human body after being eaten for a long time.
Wherein, the grape seed extract is an effective active nutrient component extracted from natural grape seeds, and is a novel high-efficiency natural antioxidant substance which can not be synthesized in human body. The antioxidant and free radical scavenging agent is a substance which is found in nature and has the strongest capacity of resisting oxidation and scavenging free radicals, the antioxidant activity of the antioxidant and free radical scavenging agent is 50 times that of vitamin E and 20 times that of vitamin C, the antioxidant and free radical scavenging agent can effectively scavenge redundant free radicals in a human body, and the antioxidant and free radical scavenging agent has the superstrong functions of delaying senility and enhancing immunity. Procyanidin is the main active ingredient in grape seed extract, can repair injured collagen and elastic fiber, has astringent effect, can tighten skin, prevent skin wrinkle from appearing in advance, can make skin smooth and elastic after long-term use, and has effects of caring skin.
The queen bee larva is also called bee larva, is an embryo nutrient body developed by sucking a large amount of royal jelly before bee eggs are hatched to the larva to form pupae, is a noble nourishing food containing high protein, multiple vitamins and trace elements, is a palace tribute in ancient times, and has strong dietotherapy effect on neurasthenia and female endocrine dyscrasia. The first pharmacopoeia of China, Shennong Ben Cao Jing, ranks the Chinese pharmacopoeia as the superior product, "flat taste, slight cold, no toxicity, deficiency tonifying, impairment reinforcing, luster, good color, light weight and qi benefiting after long-term use". The queen bee embryo extract contains more than fifty nutrient elements required by human body, including abundant protein (more than 40% of dry matter in freeze-drying), more than 16 amino acids, nearly twenty mineral substances such as multivitamins, calcium, zinc, iron, copper, selenium, manganese, magnesium, etc., trace elements, superoxide dismutase, taurine, etc.
The rhodiola rosea extract mainly comprises salidroside, aglycon tyrosol and rosavin, can improve the immunity and muscle movement capacity of organisms, increase the SOD activity in vivo, reduce the content of triglyceride, adjust the ratio of cAMP to cGMP in vivo, has the effects of delaying aging, promoting protein synthesis, reducing the activity of acidic phosphatase, and inhibiting the formation of lipid peroxide so as to eliminate free radicals in vivo.
The astragalus extract mainly contains astragalus polysaccharide, wherein the astragalus polysaccharide comprises hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid, glucuronic acid and the like, can be used as an immune promoter or regulator, can increase the nonspecific resistance of an organism, is commonly used as an immune enhancer clinically, and has the functions of resisting virus, tumor, aging, radiation, stress, oxidation and the like.
Wherein the radix Angelicae sinensis extract has effects of promoting blood circulation, removing blood stasis, enhancing blood circulation of capillary vessel, and improving and enhancing skin metabolism.
The deep-sea fish collagen peptide has the effects of locking water, storing water, resisting wrinkles, delaying aging, smoothing fine lines, removing speckles and freckles, enhancing skin compactness, promoting cell metabolism, delaying cell aging and the like.
Among them, vitamin C is also called ascorbic acid, and it helps to reduce damage of free radicals to the skin, and helps to reduce wrinkles and improve the skin structure. Scientific experiments prove that free radicals and lipid peroxide are important causes of human body aging, sufficient vitamin C can inhibit the formation of harmful substances such as free radicals and lipid peroxide in vivo, reduce the pigmentation of skin melanin, make the skin white and delay the aging of human body.
Preferably, the deep sea fish collagen peptide consists of sea bass collagen peptide and cod collagen peptide, and the mass ratio of the sea bass collagen peptide to the cod collagen peptide is 0.5-5: 1-10.
Preferably, the health-care particles with the effects of maintaining beauty and keeping young and resisting aging comprise the following raw materials in parts by weight: 12 parts of grape seed extract, 7 parts of queen bee larva powder, 3 parts of rhodiola rosea extract, 4.2 parts of astragalus extract, 2.1 parts of angelica extract, 10 parts of deep sea fish collagen peptide, 2 parts of green tea extract, 1 parts of vitamin C, 85 parts of water-soluble cyclodextrin, 1 part of flavoring agent and 0.5 part of lubricant.
Preferably, the flavoring agent is at least one of mannitol and xylitol, and the lubricant is at least one of magnesium stearate and zinc stearate.
The health-care particle with the effects of maintaining beauty and keeping young and resisting aging is prepared by the following steps of:
(1) placing grape seeds in an extraction tank, adding a 5-20 wt% ethanol water solution 2-3 times the volume of the grape seeds, and soaking and extracting for 2-3 hours;
(2) collecting the extracting solution obtained in the step (1), evaporating and recovering ethanol, extracting with ethyl acetate, recovering ethyl acetate from the extracting solution, dissolving with water, purifying with macroporous resin, eluting with 60-80 wt% ethanol water solution, and finally concentrating, drying and crushing the eluent to obtain the grape seed extract.
The health-care particle with the effects of maintaining beauty and keeping young and resisting aging is characterized in that the preparation method of the queen bee larva powder comprises the following steps:
A. putting queen bee embryo into vacuum freeze-drying machine for freeze-drying;
B. and D, grinding the freeze-dried queen bee embryo obtained in the step A into fine powder of 100-130 meshes to obtain the queen bee embryo powder.
Preferably, the lyophilization process in the step A comprises the following steps: freezing the queen bee larva at a low temperature of-40 to-25 ℃ for 2 to 3 hours, slowly heating to 40 to 48 ℃, and then preserving heat for 4 to 7 hours to finish the freeze drying of the queen bee larva.
Preferably, the temperature rise rate in step A is 10 ℃/2 h.
The health-care particle with the effects of maintaining beauty and keeping young and resisting aging is characterized in that the preparation method of the rhodiola rosea extract comprises the following steps:
a. crushing rhodiola rosea to 50-100 meshes, adding 5-20 times of 5-20 wt% ethanol water solution by mass, and leaching for 1-7 hours at 30-60 ℃ to obtain an extracting solution;
b. and (b) concentrating the extracting solution obtained in the step a by 10-50 times to obtain a concentrated solution, adsorbing and purifying the obtained concentrated solution by using macroporous adsorption resin, eluting by using 10-95 wt% of ethanol water solution, and collecting eluent to obtain the rhodiola rosea extract.
The second aspect of the invention provides a preparation method of the health-care particles with the effects of maintaining beauty and keeping young and resisting aging, which comprises the following steps:
s1, weighing a grape seed extract, queen bee embryo powder, a rhodiola root extract, an astragalus extract, an angelica extract, deep sea fish collagen peptide, a green tea extract, vitamin C, water-soluble cyclodextrin, a flavoring agent and a lubricating agent according to the formula ratio;
s2, uniformly mixing the grape seed extract, the queen bee larva powder, the rhodiola rosea extract, the astragalus extract, the angelica extract, the deep sea fish collagen peptide, the green tea extract and the vitamin C which are weighed in the step S1 to obtain a mixture A;
s3, uniformly mixing the water-soluble cyclodextrin weighed in the step S1, a flavoring agent and a lubricant to obtain a mixture B;
s4, adding 50-80 wt% of ethanol water solution into the mixture A obtained in the step S2, performing cold soaking extraction for 2-3 times, filtering, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.3-1.35 (60 ℃);
s5, adding the mixture B obtained in the step S3 into the thick paste obtained in the step S4, uniformly stirring, spray-drying, crushing, granulating, grading, and performing microwave sterilization to obtain the health-care granules with the effects of maintaining beauty, keeping young and resisting aging.
Compared with the prior art, the invention has the beneficial effects that:
1. the health-care particle with the effects of maintaining beauty and keeping young and resisting aging is prepared by compounding grape seed extract, queen bee embryo powder, rhodiola rosea extract, astragalus extract, angelica extract, deep-sea fish collagen peptide, green tea extract, vitamin C, water-soluble cyclodextrin, flavoring agent and lubricant, has no toxic or side effect, is convenient to eat and carry and store, and has the effects of maintaining beauty and keeping young, delaying aging and enhancing the immune function of a human body after being eaten for a long time.
2. The preparation method of the health-care particles with the effects of maintaining beauty, keeping young and resisting aging, disclosed by the invention, has the advantages of simple process, readily available raw materials, no waste liquid discharge in the preparation process, accordance with the environmental protection requirement and convenience for realizing industrial production.
Drawings
FIG. 1 is a process flow diagram of the process for preparing a grape seed extract according to the present invention;
FIG. 2 is a process flow chart of the preparation method of queen bee embryo powder of the present invention;
FIG. 3 is a process flow diagram of the preparation method of rhodiola rosea extract according to the present invention;
FIG. 4 is a process flow diagram of a method for preparing health granules with skin caring and anti-aging effects according to the present invention;
FIG. 5 is a graph showing the results of detection of SOD activity in serum of each group of mice in test example 2;
FIG. 6 is a graph showing the results of detecting GSH-PX activity in each group of mice in test example 2.
Detailed Description
In order to make the technical means of the implementation of the present invention, and the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships conventionally put in use of products of the present invention, and are only for convenience of description and simplification of description, but do not indicate or imply that the devices or elements referred to must have specific orientations, be constructed in specific orientations, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," and "connected" are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1
Referring to fig. 1, this embodiment provides a method for preparing a grape seed extract, including the following steps:
(1) placing grape seeds in an extraction tank, adding 20 wt% ethanol water solution with volume 3 times of that of the grape seeds, soaking and extracting for 2.5 hours;
(2) collecting the extracting solution in the step (1), evaporating and recovering ethanol, extracting with ethyl acetate, recovering ethyl acetate from the extracting solution, dissolving with water, purifying with macroporous resin, eluting with 70 wt% ethanol water solution, concentrating the eluent, drying, and pulverizing to obtain grape seed extract.
Example 2
Referring to fig. 2, this embodiment provides a preparation method of queen bee larva powder, including the following steps:
A. putting queen bee embryo into vacuum freeze-drying machine for freeze-drying;
B. and D, grinding the freeze-dried queen bee embryo obtained in the step A into fine powder of 120 meshes to obtain queen bee embryo powder.
Wherein, the freeze-drying treatment in the step A comprises the following steps: freezing queen bee embryo at-30 deg.C for 2 hr, slowly heating to 40 deg.C, and keeping the temperature for 5 hr to complete freeze drying of queen bee embryo.
Specifically, the temperature increase rate in step A was 10 ℃/2 h.
Example 3
Referring to fig. 3, this embodiment provides a method for preparing a rhodiola rosea extract, including the following steps:
a. pulverizing radix Rhodiolae to 80 mesh, adding 10 times of 20 wt% ethanol water solution, and extracting at 45 deg.C for 5 hr to obtain extractive solution;
b. and (b) concentrating the extracting solution obtained in the step a by 30 times to obtain a concentrated solution, adsorbing and purifying the obtained concentrated solution by using macroporous adsorption resin, eluting by using 90 wt% ethanol water solution, and collecting eluent to obtain the rhodiola rosea extract.
Example 4
The embodiment provides a health-care particle with effects of maintaining beauty and keeping young and resisting aging, which comprises the following raw materials by weight: 15g of grape seed extract, 10g of queen bee larva powder, 5g of rhodiola rosea extract, 6.5g of astragalus extract, 4g of angelica extract, 15g of deep sea fish collagen peptide, 3g of green tea extract, vitamin C6g, 113g of water-soluble cyclodextrin, 1.2g of flavoring agent and 0.5g of lubricant.
Wherein, the flavoring agent is a mixture of mannitol and xylitol, and the mass ratio of mannitol to xylitol is 1: 1.
wherein the lubricant is magnesium stearate.
The deep-sea fish collagen peptide consists of sea bass collagen peptide and cod collagen peptide, and the mass ratio of the sea bass collagen peptide to the cod collagen peptide is 1: 2.
In addition, referring to fig. 4, the preparation method of the health-care particle with the effects of maintaining beauty and keeping young and resisting aging in the embodiment includes the following steps:
s1, weighing a grape seed extract, queen bee embryo powder, a rhodiola root extract, an astragalus extract, an angelica extract, deep sea fish collagen peptide, a green tea extract, vitamin C, water-soluble cyclodextrin, a flavoring agent and a lubricating agent according to the formula ratio;
s2, uniformly mixing the grape seed extract, the queen bee larva powder, the rhodiola rosea extract, the astragalus extract, the angelica extract, the deep sea fish collagen peptide, the green tea extract and the vitamin C which are weighed in the step S1 to obtain a mixture A;
s3, uniformly mixing the water-soluble cyclodextrin weighed in the step S1, a flavoring agent and a lubricant to obtain a mixture B;
s4, adding 70 wt% ethanol water solution into the mixture A obtained in the step S2, cold soaking and extracting for 3 times, filtering, combining filtrates, concentrating to obtain thick paste, and concentrating by taking water as a reference substance until the relative density of the thick paste is 1.3-1.35 (60 ℃);
s5, adding the mixture B obtained in the step S3 into the thick paste obtained in the step S4, uniformly stirring, spray-drying, crushing, granulating, grading, and performing microwave sterilization to obtain the health-care granules with the effects of maintaining beauty, keeping young and resisting aging.
Example 5
The embodiment provides a health-care particle with effects of maintaining beauty and keeping young and resisting aging, which comprises the following raw materials by weight: 5g of grape seed extract, 2g of queen bee embryo powder, 1g of rhodiola rosea extract, 2g of astragalus extract, 1g of angelica extract, 5g of deep sea fish collagen peptide, 0.2g of green tea extract, 0.1g of vitamin C, 30g of water-soluble cyclodextrin, 0.5g of flavoring agent and 0.1g of lubricant.
Wherein, the flavoring agent is a mixture of mannitol and xylitol, and the mass ratio of mannitol to xylitol is 1: 1.
wherein the lubricant is magnesium stearate.
The deep-sea fish collagen peptide consists of sea bass collagen peptide and cod collagen peptide, and the mass ratio of the sea bass collagen peptide to the cod collagen peptide is 1: 2.
In addition, referring to fig. 4, the preparation method of the health-care particle with the effects of maintaining beauty and keeping young and resisting aging in the embodiment includes the following steps:
s1, weighing a grape seed extract, queen bee embryo powder, a rhodiola root extract, an astragalus extract, an angelica extract, deep sea fish collagen peptide, a green tea extract, vitamin C, water-soluble cyclodextrin, a flavoring agent and a lubricating agent according to the formula ratio;
s2, uniformly mixing the grape seed extract, the queen bee larva powder, the rhodiola rosea extract, the astragalus extract, the angelica extract, the deep sea fish collagen peptide, the green tea extract and the vitamin C which are weighed in the step S1 to obtain a mixture A;
s3, uniformly mixing the water-soluble cyclodextrin weighed in the step S1, a flavoring agent and a lubricant to obtain a mixture B;
s4, adding 70 wt% ethanol water solution into the mixture A obtained in the step S2, cold soaking and extracting for 3 times, filtering, combining filtrates, concentrating to obtain thick paste, and concentrating by taking water as a reference substance until the relative density of the thick paste is 1.3-1.35 (60 ℃);
s5, adding the mixture B obtained in the step S3 into the thick paste obtained in the step S4, uniformly stirring, spray-drying, crushing, granulating, grading, and performing microwave sterilization to obtain the health-care granules with the effects of maintaining beauty, keeping young and resisting aging.
Example 6
The embodiment provides a health-care particle with effects of maintaining beauty and keeping young and resisting aging, which comprises the following raw materials by weight: 12g of grape seed extract, 7g of queen bee larva powder, 3g of rhodiola rosea extract, 4.2g of astragalus extract, 2.1g of angelica extract, 10g of deep sea fish collagen peptide, 2g of green tea extract, vitamin C1g, 85g of water-soluble cyclodextrin, 1g of flavoring agent and 0.5g of lubricating agent.
Wherein, the flavoring agent is a mixture of mannitol and xylitol, and the mass ratio of mannitol to xylitol is 1: 1.
wherein the lubricant is magnesium stearate.
The deep-sea fish collagen peptide consists of sea bass collagen peptide and cod collagen peptide, and the mass ratio of the sea bass collagen peptide to the cod collagen peptide is 1: 2.
In addition, referring to fig. 4, the preparation method of the health-care particle with the effects of maintaining beauty and keeping young and resisting aging in the embodiment includes the following steps:
s1, weighing a grape seed extract, queen bee embryo powder, a rhodiola root extract, an astragalus extract, an angelica extract, deep sea fish collagen peptide, a green tea extract, vitamin C, water-soluble cyclodextrin, a flavoring agent and a lubricating agent according to the formula ratio;
s2, uniformly mixing the grape seed extract, the queen bee larva powder, the rhodiola rosea extract, the astragalus extract, the angelica extract, the deep sea fish collagen peptide, the green tea extract and the vitamin C which are weighed in the step S1 to obtain a mixture A;
s3, uniformly mixing the water-soluble cyclodextrin weighed in the step S1, a flavoring agent and a lubricant to obtain a mixture B;
s4, adding 70 wt% ethanol water solution into the mixture A obtained in the step S2, cold soaking and extracting for 3 times, filtering, combining filtrates, concentrating to obtain thick paste, and concentrating by taking water as a reference substance until the relative density of the thick paste is 1.3-1.35 (60 ℃);
s5, adding the mixture B obtained in the step S3 into the thick paste obtained in the step S4, uniformly stirring, spray-drying, crushing, granulating, grading, and performing microwave sterilization to obtain the health-care granules with the effects of maintaining beauty, keeping young and resisting aging.
Test example 1
And (5) a test of efficacy of maintaining beauty and keeping young.
The health granules of example 4, example 5 and example 6 were subjected to clinical tests.
80 female subjects, age 30-60 years, were selected and randomized into four groups of 20 individuals each, the first group being a control group and the second, third and fourth groups being a test diet group. The following symptoms were present in all 80 female subjects: the face is dark and light, and has little luster; rough skin, not fine enough; dark skin, hyperpigmentation; sallow complexion and lack of ruddiness; more wrinkles, and haggard; has chloasma and black speck. Wherein, 20g of the health-care granules in the second group are taken once a day in the morning and evening, 20g of the health-care granules in the third group are taken once a day in the morning and evening, and 20g of the health-care granules in the fourth group are taken once a day in the morning and evening, and the curative effect is judged after the health-care granules in the third group are taken for 4 months continuously.
The therapeutic effect criteria are as follows:
1. the effect is shown: the face color is changed from dark to light, and the face is glossy; the skin roughness is improved, and the skin is fine and smooth; improvement of dark skin, fair skin, reduction of melanin; the complexion is improved to be sallow and yellow, and the complexion is ruddy; the wrinkles are reduced and lightened; the areas of chloasma and black speck are reduced, and the color is lightened.
2. The method has the following advantages: improve complexion, skin, wrinkle and black spot.
3. And (4) invalidation: the appearance is unchanged.
After four months, the first group of 20 people has 1 effective person, 3 effective persons and 16 ineffective persons, and the total effective rate is 20%; in the second group of 20 people, 10 people are effective, 9 people are effective, 1 person is ineffective, and the total effective rate is 95%; in the third group of 20 people, 8 people are effective, 10 people are effective, and 2 people are ineffective, and the total effective rate is 90%; in the fourth group of 20 people, 14 people with obvious effect, 5 people with effect and 1 person with no effect exist, and the total effective rate is 95%. From the above, the health-care particles of the present invention have excellent effects of maintaining beauty and keeping young.
Test example 2
And (5) an anti-aging efficacy test.
Randomly dividing 100 mice into 4 groups, wherein the first group is a control group, and is not administered with any health granule and is on normal diet; the other 3 groups were administered the health granules provided in examples 4-6, respectively, in addition to the normal diet. Wherein the second group is administered with the health promoting granules provided in example 4, the third group is administered with the health promoting granules provided in example 5, and the fourth group is administered with the health promoting granules provided in example 6. After 28 days of continuous gavage, the mice were sacrificed and blood was taken to prepare serum, and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the serum were measured, and the results are shown in FIGS. 5 and 6.
As can be seen from fig. 5 and 6, the health-care granules of the present invention have excellent anti-aging effects, wherein the anti-aging effects of the health-care granules of example 6 are better than those of examples 4 and 5.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (9)

1. A health-care particle with effects of maintaining beauty and keeping young and resisting aging is characterized by comprising the following raw materials in parts by weight: 5-15 parts of grape seed extract, 1-10 parts of queen bee larva powder, 0.5-5 parts of rhodiola rosea extract, 2-6.5 parts of astragalus extract, 1-4 parts of angelica extract, 5-15 parts of deep sea fish collagen peptide, 0.2-3 parts of green tea extract, 0.1-6 parts of vitamin C, 10-120 parts of water-soluble cyclodextrin, 0.2-2 parts of flavoring agent and 0.1-1 part of lubricant.
2. The health-care particle with the effects of maintaining beauty and keeping young and resisting aging as claimed in claim 1, which comprises the following raw materials in parts by weight: 12 parts of grape seed extract, 7 parts of queen bee larva powder, 3 parts of rhodiola rosea extract, 4.2 parts of astragalus extract, 2.1 parts of angelica extract, 10 parts of deep sea fish collagen peptide, 2 parts of green tea extract, 1 parts of vitamin C, 85 parts of water-soluble cyclodextrin, 1 part of flavoring agent and 0.5 part of lubricant.
3. The health granule with effects of caring skin and resisting aging according to claim 1, wherein the correctant is at least one of mannitol and xylitol, and the lubricant is at least one of magnesium stearate and zinc stearate.
4. The health-care particle with the effects of maintaining beauty and keeping young and resisting aging as claimed in claim 1, wherein the preparation method of the grape seed extract comprises the following steps:
(1) placing grape seeds in an extraction tank, adding a 5-20 wt% ethanol water solution 2-3 times the volume of the grape seeds, and soaking and extracting for 2-3 hours;
(2) collecting the extracting solution obtained in the step (1), evaporating and recovering ethanol, extracting with ethyl acetate, recovering ethyl acetate from the extracting solution, dissolving with water, purifying with macroporous resin, eluting with 60-80 wt% ethanol water solution, and finally concentrating, drying and crushing the eluent to obtain the grape seed extract.
5. The health granule with skin caring and anti-aging effects as claimed in claim 1, wherein the preparation method of queen bee embryo powder comprises the following steps:
A. putting queen bee embryo into vacuum freeze-drying machine for freeze-drying;
B. and D, grinding the freeze-dried queen bee embryo obtained in the step A into fine powder of 100-130 meshes to obtain the queen bee embryo powder.
6. The health-care particle with the effects of maintaining beauty and keeping young and resisting aging as claimed in claim 5, wherein the freeze-drying treatment in the step A comprises the following steps: freezing the queen bee larva at a low temperature of-40 to-25 ℃ for 2 to 3 hours, slowly heating to 40 to 48 ℃, and then preserving heat for 4 to 7 hours to finish the freeze drying of the queen bee larva.
7. The health granule with skin caring and anti-aging effects as claimed in claim 6, wherein the temperature rising rate in step A is 10 ℃/2 h.
8. The health-care granule with the effects of maintaining beauty and keeping young and resisting aging as claimed in claim 1, wherein the preparation method of the rhodiola rosea extract comprises the following steps:
a. crushing rhodiola rosea to 50-100 meshes, adding 5-20 times of 5-20 wt% ethanol water solution by mass, and leaching for 1-7 hours at 30-60 ℃ to obtain an extracting solution;
b. and (b) concentrating the extracting solution obtained in the step a by 10-50 times to obtain a concentrated solution, adsorbing and purifying the obtained concentrated solution by using macroporous adsorption resin, eluting by using 10-95 wt% of ethanol water solution, and collecting eluent to obtain the rhodiola rosea extract.
9. A method for preparing the health-care granules with the effects of maintaining beauty and keeping young and resisting aging according to any one of claims 1 to 8, which comprises the following steps:
s1, weighing a grape seed extract, queen bee embryo powder, a rhodiola root extract, an astragalus extract, an angelica extract, deep sea fish collagen peptide, a green tea extract, vitamin C, water-soluble cyclodextrin, a flavoring agent and a lubricating agent according to the formula ratio;
s2, uniformly mixing the grape seed extract, the queen bee larva powder, the rhodiola rosea extract, the astragalus extract, the angelica extract, the deep sea fish collagen peptide, the green tea extract and the vitamin C which are weighed in the step S1 to obtain a mixture A;
s3, uniformly mixing the water-soluble cyclodextrin weighed in the step S1, a flavoring agent and a lubricant to obtain a mixture B;
s4, adding 50-80 wt% of ethanol water solution into the mixture A obtained in the step S2, performing cold soaking extraction for 2-3 times, filtering, combining filtrates, and concentrating to obtain thick paste with the relative density of 1.3-1.35 (60 ℃);
s5, adding the mixture B obtained in the step S3 into the thick paste obtained in the step S4, uniformly stirring, spray-drying, crushing, granulating, grading, and performing microwave sterilization to obtain the health-care granules with the effects of maintaining beauty, keeping young and resisting aging.
CN202011133319.3A 2020-10-21 2020-10-21 Health-care granules with effects of maintaining beauty and keeping young and resisting aging and preparation method thereof Pending CN114376212A (en)

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