CN100453091C - Capsule of purple sweet potato, its production and application - Google Patents
Capsule of purple sweet potato, its production and application Download PDFInfo
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- CN100453091C CN100453091C CNB2005100442084A CN200510044208A CN100453091C CN 100453091 C CN100453091 C CN 100453091C CN B2005100442084 A CNB2005100442084 A CN B2005100442084A CN 200510044208 A CN200510044208 A CN 200510044208A CN 100453091 C CN100453091 C CN 100453091C
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Abstract
The present invention relates to capsules of purple sweet potatoes, the producing method and an application thereof. The contents of each capsule are 300 mg and are pigment liquid of which the color number is 100, and the pigment liquid is produced by the acidic extraction products of the purple sweet potatoes; a main active component comprises 9.69 mg of the extraction products of the purple sweet potatoes, and freeze drying powder of the pigment sweet potatoes, wherein 9.69 mg of the extraction products of the purple sweet potatoes is equivalent to 0.084 mg of proanthocyanidin, and 9.602 mg of total flavonoids; the freeze drying powder of the pigment sweet potatoes is drying powder made by the steps of freezing and dehydration as auxiliary material, and the drying powder can pass through a sieve with 200 meshes. 15 to 1500 mg/kg of the extraction liquid of the pigment sweet potatoes is used for improving the SOD activity, GSH-PX activity and the T-AOC capability of the senile cerebrum, the senile heart, the senile lung, the senile liver, the senile thymus and the senile spleen and reducing the contents of MDA and ROS by a mouse experiment. The radiation damage caused by 60Co gamma-rays is inhibited; a cellular membranous structure is kept. The products can be used in the preparation of health-care products for improving human-body immunity and in the preparation of auxiliary therapeutic medicaments for preventing and treating tumors.
Description
Technical field
The invention belongs to nutritive health products, particularly a kind of Rhizoma Steudnerae Henryanae capsule and method for making and application.Be applicable in the health nutrient kind of preparation human immunity regulator, free radical scavenger or antioxidant and use.
Background technology
Purple sweet potato belongs to the Convolvulaceae sweet potato genus, English name Sweet Potato, and Latin title Ipomoea batatas (L.) Lam. refers to that potato meat color is the characteristic Rhizoma Dioscoreae esculentae that the class of purple has nutrition health-care functions.
Purple sweet potato is through analysis of experiments, and the purple sweet potato of 100 color valencys proposes liquid (containing procyanidin 0.056%, total flavones 6.401%).The nutrition health-care functions that the procyanidin tool is extremely strong.Purple sweet potato lyophilized powder avirulence belongs to physiological alkalinity food (PH10～11), can keep intravital acid-base balance (the blood of human body pH value is 7.3-7.5).The purple sweet potato of taking 100 color valencys by the mouse stomach analysis of experiments proposes liquid 15-1500mg/kg, superoxide dismutase (SOD superoxide dismutase), glutathion peroxidase (GSH-PX glutathioneperoxidase) activity and total antioxidation (the T-AOC total antioxidative capacity) ability of old and feeble rat brain, heart, lung, liver, thymus and spleen tissue be can improve, malonaldehyde (MDA malondialdehyde) and active oxygen (ROS reactive oxygen species) content reduced.The purple sweet potato proposition liquid 15-1500mg/kg that takes 100 color valencys can suppress 60 Co gamma-radiations and induce the radiation damage that causes, and keeps the meinbranous structure of cell.
And only relying on daily eating, the nutritive and health protection components that it absorbed does not reach the needed dosage of nutrition health-care functions far away.
Summary of the invention
Purpose of the present invention is the further deep processing of research purple sweet potato, develops a kind of capsule of purple sweet potato and method for making thereof and application.
The invention still further relates to and reached health care, the needed lowest dose level of auxiliary treatment purpose.
Technical scheme of the present invention is:
Develop a kind of capsule of purple sweet potato, it is characterized in that:
The heavy 300mg of every capsules content is the granule of Purple Sweet Potato acidic extract and purple sweet potato lyophilized powder preparation, wherein,
Described Purple Sweet Potato acidic extract is a pigment solution of making color valency 100, is main active, and every capsules contains the amount 9.69mg of ZIROWGANSHU extract, is equivalent to procyanidin 0.084mg and total flavones 9.602mg;
Described purple sweet potato lyophilized powder is that employing is freezing---dehydration, drying, the particle diameter of making is by the dry powder of 200 mesh standard sieves, as adjuvant.
The method for making of above-mentioned capsule of purple sweet potato is characterized in that comprising the steps:
(1) preparation purple sweet potato lyophilized powder: the purple sweet potato that does not extract pigment solution, vacuum lyophilization, be cooled to-10 ℃～-30 ℃ in 2～3h, with the Rhizoma Dioscoreae esculentae after the cooling under below 0 ℃ and less than 610Pa pressure, reuse radiotechnology compensation heat makes the solid phase water sublimate, makes the rapid dehydrate of purple sweet potato piece to water content＜5%, and flour mill is pulverized, make dry powder by 200 mesh sieves, standby as adjuvant;
(2) preparation purple sweet potato extracting solution: adopt 3 times-united extraction of acid solution (1: 5) lixiviate thing-remove by filter impurity-adsorption column-eluting (95% ethanol)-recoverys ethanol-concentrated pigment solution of making color valency 100.
(3) preparation of capsule:
The purple sweet potato extracting solution of color valency 100: purple sweet potato lyophilized powder=1ml: 2g, mixing transfers viscosity to make granule with 95% ethanol, 50～70 ℃ of oven dry, No. 1 capsule of packing, the heavy 0.3g of every capsules content.
The application of above-mentioned capsule of purple sweet potato is characterized in that described capsule of purple sweet potato, can be in the application in the health product of preparation raising body immunity.
The application of above-mentioned capsule of purple sweet potato is characterized in that described capsule of purple sweet potato, can also be in the application in the auxiliary therapeutical agent of preparation prevention and treatment tumor.
Advantage of the present invention is:
1. the present invention is the nutritive and health protection components procyanidin (Procyanidins that contains according to purple sweet potato, be called for short PC) and the active constituent content of total flavones (Total Flavone), in conjunction with the result of Kunming mouse internal and external test, the technology employing science, rational is made capsule; Amount is taken the effect that can play antioxidation and remove the body free radical in accordance with regulations, reaches the nutrition health-care functions that improves body immunity, and prevention and treatment tumor are had assosting effect.
2. the processing that purple sweet potato is scientific and reasonable, extract its effective ingredient and make the capsule nutrient and healthcare products; Both can reduce dose and taking convenience, extend shelf life.
3. adopt the purple sweet potato lyophilized powder, the adjuvant as the preparation capsule has fully utilized resource.
The specific embodiment
Embodiment 1 development capsule of purple sweet potato
The heavy 300mg of every capsules content is the granule of Purple Sweet Potato acidic extract and purple sweet potato lyophilized powder preparation, wherein,
Purple Sweet Potato acidic extract is a pigment solution of making color valency 100, is main active, and every capsules contains the amount 9.69mg of ZIROWGANSHU extract, is equivalent to procyanidin 0.084mg and total flavones 9.602mg;
The purple sweet potato lyophilized powder is that employing is freezing---dehydration, drying, the particle diameter of making is by the dry powder of 200 mesh standard sieves, as adjuvant.
The method for making of above-mentioned capsule of purple sweet potato is characterized in that comprising the steps:
(1) preparation purple sweet potato lyophilized powder: the purple sweet potato that does not extract pigment solution, roguing, clean, stripping and slicing is put in the vacuum freeze dryer, is cooled to-10 ℃～-30 ℃ in 2～3h, with the Rhizoma Dioscoreae esculentae after the cooling under below 0 ℃ and less than 610Pa pressure, reuse radiotechnology compensation heat makes the solid phase water sublimate, makes the rapid dehydrate of purple sweet potato piece to water content＜5%, and flour mill is pulverized, make dry powder by 200 mesh sieves, standby as adjuvant;
(2) preparation purple sweet potato extracting solution: adopt 3 times-united extraction of acid solution (1: 5) lixiviate thing-remove by filter impurity-adsorption column-eluting (95% ethanol)-recoverys ethanol-concentrated pigment solution of making color valency 100.The acid citric acid.
(3) preparation of capsule:
The purple sweet potato extracting solution of color valency 100: purple sweet potato lyophilized powder=1ml: 2g, mixing transfers viscosity to make granule with 95% ethanol, 50～70 ℃ of oven dry, No. 1 capsule of packing, the heavy 0.3g of every capsules content.
Purple sweet potato capsule of the present invention can be used in the health product of preparation raising body immunity;
Can also in the auxiliary therapeutical agent of preparation prevention and treatment tumor, use.
Lab analysis 100 color valencys (i.e. 10% concentration, 1cm thickness, absorbing wavelength 530, symbolization is E1cm10%530) purple sweet potato propose liquid and (contain anthocyanidin 0.56mg/ml, total flavones 64.01mg/ml), (extract contains 9.69mg to be prepared into every heavy 0.3g in conjunction with the animal vivo test result.Wherein contain anthocyanidin 0.084mg, total flavones 9.602mg) capsule can play nutrition health-care functions.
The primary raw material that uses is purple sweet potato extracting solution (pigment).The main effective ingredient anthocyanidin major part of these nutrient and healthcare products is contained in the purple sweet potato pigment, makes capsule with purple sweet potato extracting solution (pigment) as main effective ingredient and can improve content of effective.
These health product determine that through testing every day, dose was 9 (including anthocyanidin 0.76mg, total flavones 86.42mg).
The present invention has carried out following research work to purple sweet potato extracting solution (pigment)
1. to mouse anti
60The effect research of Co gamma-radiation radiation damage
Duplicate
60Co (radiant intensity is 6Gy) is to the pathological model of male mice in kunming radiation damage.Experimental design is divided into 6 groups (every group of 10 mices): matched group,
60Co model group, No. 1 pigment group of low dose of livid purple potato (No. 1 pigment 15mg/kg of livid purple potato), No. 1 pigment group of the livid purple potato of middle dosage (No. 1 pigment 150mg/kg of livid purple potato), No. 1 pigment group of heavy dose of livid purple potato (No. 1 pigment 1.5g/kg of livid purple potato) and nilestriol group (nilestriol 2mg/kg), equal gastric infusion, continuous 1 month.Whole blood cell analysis instrument counting mice peripheral blood leucocyte sum; Calculate thymus coefficient and the spleen coefficient of mice; The Ultrastructural change of transmission electron microscope observing mouse chest cell; The enzyme biochemical process is measured superoxide dismutase (SOD), glutathion peroxidase (GSH-px) activity in mouse brain, thymus, liver, spleen, the lung tissue, active oxygen (ROS), malonaldehyde (MDA) content and Total antioxidant capacity (T-AOC).Studies have shown that (irritating stomach dosage and be 15～1500mg/kg) can suppress No. 1 pigment of livid purple potato
60The oxidative damage of the radiation-induced mouse brain of Co gamma-radiation, thymus, liver, spleen, lung tissue improves body's immunological function, and is right
60Co gamma-radiation radiation damage mice has protective effect.Transmission electron microscope observing the Ultrastructural change of mouse chest cell, confirm that No. 1 pigment of livid purple potato can suppress the morphological change of the early, middle and late phase apoptosis of radiogenic thymocyte cell, keeps the normal ultrastructure of cell.Superoxide dismutase in mouse brain, thymus, liver, spleen and the lung tissue (SOD), glutathion peroxidase (GSH-px) activity, active oxygen (ROS), malonaldehyde (MDA) content and Total antioxidant capacity (T-AOC) have been detected with the enzyme biochemical process.Testing result shows,
60After the irradiation of Co gamma-radiation, SOD, GSH-px activity and T-AOC descend in above-mentioned five tissues of mice, and the content of MDA and ROS significantly raises; No. 1 pigment of livid purple potato can improve SOD, GSH-px activity and T-AOC in above-mentioned each tissue, reduces the content of MDA and ROS.No. 1 pigment of its mechanism and livid purple potato improves SOD and GSH-px activity and T-AOC in mouse brain, thymus, liver, spleen, the lung tissue, reduces the generation of oxygen-derived free radicals, and it is relevant to suppress lipid peroxidation; With No. 1 pigment protection of livid purple potato cell membrane phase structure, stimulate the propagation of thymus and spleen cell relevant simultaneously.
2. the effect of mice-transplanted tumor is studied
Kunming mouse with 20g～24g is an experimental subject, inoculates S respectively
180The tumor strain.Experimental group is irritated stomach with livid purple potato No. 1 pigment 75.0g/kg, 37.5g/kg, 18.7g/kg, and negative control group, positive controls are anticarcinogen Tegafur 110mg/kg (ftorafur, FT
207).Irritate stomach with No. 1 pigment 75.0g/kg of livid purple potato every day, 3 times the experiment tumour inhibiting rate is respectively 29.7%, 45.0%, 33.3%, according to the evaluation criterion of China's antitumor drug " when tumor control rate＞30%; learn by statistics and handle significant difference is arranged (p＜0.05=thinks that then this medicine has certain curative effect to tumor ".Show that No. 1 pigment of livid purple potato has the obvious suppression effect to the solid tumor that the strain of sarcoma S180 tumor causes, and proves the using value of clinical adjuvant therapy of tumors.
In sum, Rhizoma Dioscoreae esculentae pigment and FD powder have alimentary health-care function and certain adjuvant therapy of tumors effect, and human body is had no side effect, and can be used as nutritional health food, medicine and cosmetics and develop and utilize.
Embodiment 2
During preparation Rhizoma Dioscoreae esculentae extracting solution, adopt 3 times-united extraction of acid solution (1: 5) lixiviate thing-remove by filter impurity-adsorption column-eluting (95% ethanol)-recoverys ethanol-concentrated pigment solution of making color valency 100.Salt is used in acid, and all the other are with embodiment 1.
Claims (4)
1. capsule of purple sweet potato is characterized in that:
The heavy 300mg of every capsules content is the granule of Purple Sweet Potato acidic extract and adjuvant purple sweet potato lyophilized powder preparation, wherein:
Described Purple Sweet Potato acidic extract is made the pigment solution of color valency 100, is main active, and every capsules contains the amount 9.69mg of ZIROWGANSHU extract;
Described purple sweet potato lyophilized powder is that employing is freezing---dehydration, drying, the particle diameter of making is by the dry powder of 200 mesh standard sieves, as adjuvant.
2. according to the method for making of the described a kind of capsule of purple sweet potato of claim 1, it is characterized in that comprising the steps:
(1) preparation purple sweet potato lyophilized powder: the purple sweet potato that does not extract pigment solution, vacuum lyophilization, be cooled to-10 ℃～-30 ℃ in 2～3h, reuse radiotechnology compensation heat makes the solid phase water sublimate, make the rapid dehydrate of purple sweet potato piece to water content＜5%, flour mill is pulverized, and makes the dry powder by 200 mesh sieves, and is standby as adjuvant;
(2)------------95% ethanol elution---reclaims ethanol---and concentrates the pigment solution of making color valency 100 adsorption column the united extraction thing preparation purple sweet potato extracting solution: adopt acid solution lixiviate in 1: 53 times to remove by filter impurity.
(3) preparation of capsule:
The purple sweet potato extracting solution of color valency 100: purple sweet potato lyophilized powder=1ml: 2g, mixing transfers viscosity to make granule with 95% ethanol, 50～70 ℃ of oven dry, No. 1 capsule of packing, the heavy 0.3g of every capsules content.
3. according to the application of the described a kind of capsule of purple sweet potato of claim 1, it is characterized in that the application of described capsule of purple sweet potato in the health product of preparation raising body immunity, every day, dose was 9, and the total amount that contains ZIROWGANSHU extract is 87.21mg.
4. according to the application of the described a kind of capsule of purple sweet potato of claim 1, it is characterized in that the application of described capsule of purple sweet potato in the auxiliary therapeutical agent of preparation prevention and treatment tumor, every day, dose was 9, and the total amount that contains ZIROWGANSHU extract is 87.21mg.
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| CN101889673B (en) * | 2010-07-30 | 2012-06-06 | 西华大学 | Method for preparing instant purple sweet potato microcapsule full powder |
| CN110521977A (en) * | 2018-05-24 | 2019-12-03 | 西南大学 | A kind of processing method comprehensively utilizing sweet potato |
Citations (2)
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| CN1304960A (en) * | 2000-12-12 | 2001-07-25 | 浙江大学 | Process for extracting natural red pigment from purple sweet potato with alcohol |
| CN1460694A (en) * | 2003-05-30 | 2003-12-10 | 江苏省农业科学院 | Process for extracting anthocyanin of purple sweet potato by utilizing citric acid solution |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304960A (en) * | 2000-12-12 | 2001-07-25 | 浙江大学 | Process for extracting natural red pigment from purple sweet potato with alcohol |
| CN1460694A (en) * | 2003-05-30 | 2003-12-10 | 江苏省农业科学院 | Process for extracting anthocyanin of purple sweet potato by utilizing citric acid solution |
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Owner name: QINGDAO SHUANGLONG NATURAL BIOTECHNOLOGY CO., LTD Free format text: FORMER OWNER: QINGDAO JINHE FANCY FOOD RESEARCH INSTITUTE Effective date: 20070309 |
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