CN114375193B - 甲状腺激素受体β激动剂化合物 - Google Patents

甲状腺激素受体β激动剂化合物 Download PDF

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CN114375193B
CN114375193B CN202080064319.4A CN202080064319A CN114375193B CN 114375193 B CN114375193 B CN 114375193B CN 202080064319 A CN202080064319 A CN 202080064319A CN 114375193 B CN114375193 B CN 114375193B
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CN114375193A (zh
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T·A·基尔施伯格
R·哈尔康卜
徐英姿
F·A·罗曼罗
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Tuozhen Pharmaceutical Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202080064319.4A 2019-09-12 2020-09-11 甲状腺激素受体β激动剂化合物 Active CN114375193B (zh)

Applications Claiming Priority (3)

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US201962899581P 2019-09-12 2019-09-12
US62/899,581 2019-09-12
PCT/US2020/050497 WO2021050945A1 (en) 2019-09-12 2020-09-11 Thyroid hormone receptor beta agonist compounds

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CN114375193A CN114375193A (zh) 2022-04-19
CN114375193B true CN114375193B (zh) 2024-05-14

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US (1) US12398127B2 (https=)
EP (1) EP4028008A4 (https=)
JP (2) JP2022548250A (https=)
CN (1) CN114375193B (https=)
AU (1) AU2020346057A1 (https=)
CA (1) CA3154391A1 (https=)
WO (1) WO2021050945A1 (https=)

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AU2020336272A1 (en) 2019-08-23 2022-04-14 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
WO2021050945A1 (en) 2019-09-12 2021-03-18 Terns, Inc. Thyroid hormone receptor beta agonist compounds
AU2021374988A1 (en) 2020-11-06 2023-06-15 Aligos Therapeutics, Inc. Bicyclic pyridazinones as thyroid hormone receptor beta (tr-beta) agonists
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CN116940566A (zh) * 2021-03-19 2023-10-24 南京明德新药研发有限公司 双环吡啶酮类化合物及其应用
EP4568664B1 (en) 2023-04-07 2026-04-01 Terns Pharmaceuticals, Inc. Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity

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AU2020346057A1 (en) 2022-04-21
EP4028008A1 (en) 2022-07-20
JP2026027279A (ja) 2026-02-18
US12398127B2 (en) 2025-08-26
CN114375193A (zh) 2022-04-19
WO2021050945A1 (en) 2021-03-18
JP2022548250A (ja) 2022-11-17
US20220356177A1 (en) 2022-11-10
CA3154391A1 (en) 2021-03-18
EP4028008A4 (en) 2023-09-13

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