CN114306519A - A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and its preparation method - Google Patents
A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and its preparation method Download PDFInfo
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the technical field of cardiovascular and cerebrovascular medicines. The invention provides a traditional Chinese medicine composition for cardiovascular and cerebrovascular diseases and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight: 25-35 parts of salvia miltiorrhiza, 15-20 parts of kudzu root, 12-16 parts of safflower, 2-6 parts of leech, 8-12 parts of epimedium, 13-17 parts of gastrodia elata and 10-15 parts of hawthorn. The traditional Chinese medicine composition has wide raw material sources and simple preparation process, and can effectively treat and prevent cardiovascular and cerebrovascular diseases. And no toxic or side effect is generated, and the mental pressure and the economic pressure of a patient can be effectively reduced.
Description
Technical Field
The invention relates to the technical field of cardiovascular and cerebrovascular medicines, in particular to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof.
Background
Cardiovascular and cerebrovascular diseases are the general names of cardiovascular and cerebrovascular diseases, are common diseases seriously threatening the health of human beings, especially the middle-aged and old people over 50 years old, and have the characteristics of high morbidity, high disability rate and high mortality. Even if the most advanced and perfect treatment means at present are applied, more than 50 percent of survivors can not take care of the life completely, and the number of people dying from cardiovascular and cerebrovascular diseases in each year in the world is as high as 1500 thousands of people, which live at the head of various causes of death.
With the improvement of living standard and the acceleration of life rhythm, the incidence of diseases such as hyperlipoidemia, blood viscosity, atherosclerosis, hypertension and the like is increased year by year, and obvious youthful characteristics appear. The western medicine treatment process mainly adopts vasodilating and antihypertensive medicines which have quick response, but large side effect and easy repetition and bring long-term economic and mental pressure to patients.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for cardiovascular and cerebrovascular diseases and a preparation method thereof, which can effectively treat and prevent cardiovascular and cerebrovascular diseases and reduce mental stress and economic stress of patients.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for cardiovascular and cerebrovascular diseases, which is prepared from the following components in parts by weight: 25-35 parts of salvia miltiorrhiza, 15-20 parts of kudzu root, 12-16 parts of safflower, 2-6 parts of leech, 8-12 parts of epimedium, 13-17 parts of gastrodia elata and 10-15 parts of hawthorn.
Preferably, the composition is prepared from the following components in parts by weight: 28-32 parts of salvia miltiorrhiza, 16-19 parts of kudzu root, 13-15 parts of safflower, 3-5 parts of leech, 9-11 parts of epimedium, 14-16 parts of gastrodia elata and 11-14 parts of hawthorn.
Preferably, the composition is prepared from the following components in parts by weight: 30 parts of salvia miltiorrhiza, 17-18 parts of kudzu root, 14 parts of safflower, 4 parts of leech, 10 parts of epimedium, 15 parts of gastrodia elata and 12-13 parts of hawthorn.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) crushing the raw materials, adding water, and soaking for 4-8 hours to obtain a mixture;
(2) carrying out ultrasonic extraction on the mixture, and filtering to obtain an extracting solution 1 and residues;
(3) adding water into the residue, and performing ultrasonic extraction again to obtain an extracting solution 2;
(4) and combining the extracting solution 1 and the extracting solution 2, and concentrating to obtain the traditional Chinese medicine composition.
Preferably, the particle size of the crushed raw materials in the step (1) is 2-5 mm, and the mass ratio of the raw materials to water in the step (1) is 1: 16 to 20.
Preferably, the ultrasonic extraction time in the step (2) is 25-30 min, and the ultrasonic power is 220-260 w.
Preferably, the mass ratio of the residue to the water in the step (3) is 1: 10 to 15.
Preferably, the ultrasonic extraction time in the step (3) is 15-20 min, and the ultrasonic power is 200-240 w.
Preferably, the volume of the Chinese medicinal composition concentrated in the step (4) is 10-15% of the total volume of the extracting solution 1 and the extracting solution 2.
The invention provides a traditional Chinese medicine composition for cardiovascular and cerebrovascular diseases and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight: 25-35 parts of salvia miltiorrhiza, 15-20 parts of kudzu root, 12-16 parts of safflower, 2-6 parts of leech, 8-12 parts of epimedium, 13-17 parts of gastrodia elata and 10-15 parts of hawthorn. The traditional Chinese medicine composition has wide raw material sources and simple preparation process, and can effectively treat and prevent cardiovascular and cerebrovascular diseases. And no toxic or side effect is generated, and the mental pressure and the economic pressure of a patient can be effectively reduced.
Detailed Description
The invention provides a traditional Chinese medicine composition for cardiovascular and cerebrovascular diseases, which is prepared from the following components in parts by weight: 25-35 parts of salvia miltiorrhiza, 15-20 parts of kudzu root, 12-16 parts of safflower, 2-6 parts of leech, 8-12 parts of epimedium, 13-17 parts of gastrodia elata and 10-15 parts of hawthorn.
In the invention, the preferable part of the salvia miltiorrhiza is 28-32 parts, and the more preferable part is 30 parts.
In the invention, the kudzuvine root is preferably 16-19 parts, and more preferably 17-18 parts.
In the present invention, the safflower is preferably 13 to 15 parts, and more preferably 14 parts.
In the present invention, the leech is preferably 3 to 5 parts, and more preferably 4 parts.
In the invention, the preferable part of the epimedium is 9-11 parts, and the more preferable part is 10 parts.
In the present invention, the number of parts of the gastrodia elata is preferably 14 to 16, and more preferably 15.
In the present invention, the proportion of the hawthorn is preferably 11 to 14 parts, and more preferably 12 to 13 parts.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) crushing the raw materials, adding water, and soaking for 4-8 hours to obtain a mixture;
(2) carrying out ultrasonic extraction on the mixture, and filtering to obtain an extracting solution 1 and residues;
(3) adding water into the residue, and performing ultrasonic extraction again to obtain an extracting solution 2;
(4) and combining the extracting solution 1 and the extracting solution 2, and concentrating to obtain the traditional Chinese medicine composition.
In the present invention, the particle size of the pulverized raw material in the step (1) is preferably 2 to 5mm, and more preferably 3 to 4 mm.
In the present invention, the mass ratio of the raw material to water in the step (1) is preferably 1: 16-20, and more preferably 1: 17 to 19, and more preferably 1: 18.
in the invention, the soaking time in the step (1) is preferably 5-7, and more preferably 6 h.
In the invention, the time for ultrasonic extraction in the step (2) is preferably 25-30 min, more preferably 26-29 min, and still more preferably 27-28 min.
In the invention, the power of the ultrasonic wave is preferably 220-260W, more preferably 230-250W, and still more preferably 240W.
In the present invention, the mass ratio of the residue to water in the step (3) is preferably 1: 10-15, and more preferably 1: 11 to 14, and more preferably 1: 12 to 13.
In the invention, the time for ultrasonic extraction in the step (3) is preferably 15-20 min, more preferably 16-19 min, and still more preferably 17-18 min.
In the invention, the power of the ultrasonic wave is preferably 200-240W, more preferably 210-230W, and still more preferably 220W.
In the present invention, the volume of the herbal composition concentrated in the step (4) is preferably 10 to 15% of the total volume of the extract solutions 1 and 2, more preferably 11 to 14% of the total volume of the extract solutions 1 and 2, and still more preferably 12 to 13% of the total volume of the extract solutions 1 and 2.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
(1) Weighing raw materials according to the weight ratio of 25 parts of salvia miltiorrhiza, 15 parts of kudzuvine root, 12 parts of safflower, 6 parts of leech, 12 parts of epimedium, 13 parts of gastrodia elata and 15 parts of hawthorn;
(2) crushing the raw materials into small pieces of 2mm, and adding water with the mass of 16 times to soak for 4 hours to obtain a mixture;
(3) ultrasonically extracting the mixture for 30min under the condition of 220w, and filtering to obtain an extracting solution 1 and residues;
(4) adding 15 times of water into the residue, and performing ultrasonic extraction for 20min under the condition of 200w to obtain an extracting solution 2;
(5) and mixing the extracting solution 1 and the extracting solution 2, and concentrating the mixed solution of the extracting solution 1 and the extracting solution 2 to 15% of the original volume to obtain the traditional Chinese medicine composition.
Example 2
(1) Weighing raw materials according to the weight ratio of 35 parts of salvia miltiorrhiza, 20 parts of kudzuvine root, 16 parts of safflower, 2 parts of leech, 8 parts of epimedium herb, 17 parts of tall gastrodia tuber and 10 parts of hawthorn;
(2) crushing the raw materials into small blocks of 5mm, and adding water with the mass of 20 times of the raw materials to soak for 8 hours to obtain a mixture;
(3) ultrasonically extracting the mixture for 25min under the condition of 260w, and filtering to obtain an extracting solution 1 and residues;
(4) adding 10 times of water into the residue, and performing ultrasonic extraction for 15min under 240w to obtain an extract 2;
(5) and mixing the extracting solution 1 and the extracting solution 2, and concentrating the mixed solution of the extracting solution 1 and the extracting solution 2 to 10 percent of the original volume to obtain the traditional Chinese medicine composition.
Example 3
(1) Weighing the raw materials according to the weight ratio of 30 parts of salvia miltiorrhiza, 17 parts of kudzuvine root, 14 parts of safflower, 4 parts of leech, 10 parts of epimedium, 15 parts of gastrodia elata and 13 parts of hawthorn;
(2) crushing the raw materials into small blocks with the size of 3mm, and adding water with the mass of 18 times of the raw materials to soak for 6 hours to obtain a mixture;
(3) performing ultrasonic extraction on the mixture for 28min under the condition of 240w, and filtering to obtain an extracting solution 1 and residues;
(4) adding 13 times of water into the residue, and performing ultrasonic extraction for 17min under 220w to obtain an extract 2;
(5) and combining the extracting solution 1 and the extracting solution 2, and concentrating the mixed solution of the extracting solution 1 and the extracting solution 2 to 13 percent of the original volume to obtain the traditional Chinese medicine composition.
Test examples
100 of the recruited volunteers all suffered from cardiovascular and cerebrovascular diseases, wherein 53 of the males and 47 of the females have the age of 51-73 years and the course of the disease is more than 12 months; 100 patients were randomized into 4 groups of 25 patients each. The medicines are numbered as a control group and test groups 1-3, wherein patients in the control group take the medicines for treating cardiovascular and cerebrovascular diseases sold in the market according to the medicine instruction, and the test groups 1-3 respectively take the traditional Chinese medicine composition prepared in the embodiments 1-3 of the application for 2 times a day, and each time is 80 ml. The test was carried out for a total of 140 days. The cure rate was counted after the test was completed, and the results are shown in table 1.
TABLE 1
| Group of | Initial number of people | The number of people who take off the group | Number of good turning people | The number of people cured | Number of invalid persons | Total effective rate |
| Control group | 25 | 3 | 4 | 13 | 5 | 77.3％ |
| Test group 1 | 25 | 1 | 3 | 20 | 1 | 95.8％ |
| Test group 2 | 25 | 0 | 3 | 20 | 2 | 92.0％ |
| Test group 3 | 25 | 3 | 5 | 16 | 1 | 95.5％ |
And (4) conclusion: the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases prepared by the application has wide raw material sources and simple preparation process, can effectively treat and prevent cardiovascular and cerebrovascular diseases, has the total effective rate improved by more than 14.7 percent compared with the commercially available medicines, and has no adverse reaction when patients follow up.
The embodiment of the invention can show that the invention provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following components in parts by weight: 25-35 parts of salvia miltiorrhiza, 15-20 parts of kudzu root, 12-16 parts of safflower, 2-6 parts of leech, 8-12 parts of epimedium, 13-17 parts of gastrodia elata and 10-15 parts of hawthorn. The traditional Chinese medicine composition has wide raw material sources and simple preparation process, and can effectively treat and prevent cardiovascular and cerebrovascular diseases. And no toxic or side effect is generated, and the mental pressure and the economic pressure of a patient can be effectively reduced.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. A traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases is characterized by being prepared from the following components in parts by weight: 25-35 parts of salvia miltiorrhiza, 15-20 parts of kudzu root, 12-16 parts of safflower, 2-6 parts of leech, 8-12 parts of epimedium, 13-17 parts of gastrodia elata and 10-15 parts of hawthorn.
2. The traditional Chinese medicine composition for the cardiovascular and cerebrovascular diseases according to claim 1, which is prepared from the following components in parts by weight: 28-32 parts of salvia miltiorrhiza, 16-19 parts of kudzu root, 13-15 parts of safflower, 3-5 parts of leech, 9-11 parts of epimedium, 14-16 parts of gastrodia elata and 11-14 parts of hawthorn.
3. The traditional Chinese medicine composition for the cardiovascular and cerebrovascular diseases according to claim 1 or 2, which is prepared from the following components in parts by weight: 30 parts of salvia miltiorrhiza, 17-18 parts of kudzu root, 14 parts of safflower, 4 parts of leech, 10 parts of epimedium, 15 parts of gastrodia elata and 12-13 parts of hawthorn.
4. The preparation method of the traditional Chinese medicine composition as claimed in any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) crushing the raw materials, adding water, and soaking for 4-8 hours to obtain a mixture;
(2) carrying out ultrasonic extraction on the mixture, and filtering to obtain an extracting solution 1 and residues;
(3) adding water into the residue, and performing ultrasonic extraction again to obtain an extracting solution 2;
(4) and combining the extracting solution 1 and the extracting solution 2, and concentrating to obtain the traditional Chinese medicine composition.
5. The preparation method according to claim 4, wherein the particle size of the pulverized raw material in the step (1) is 2-5 mm, and the mass ratio of the raw material to water in the step (1) is 1: 16 to 20.
6. The preparation method according to claim 5, wherein the ultrasonic extraction time in the step (2) is 25-30 min, and the ultrasonic power is 220-260 w.
7. The method according to claim 6, wherein the mass ratio of the residue to the water in the step (3) is 1: 10 to 15.
8. The preparation method according to claim 7, wherein the ultrasonic extraction time in the step (3) is 15-20 min, and the ultrasonic power is 200-240 w.
9. The method according to any one of claims 4 to 8, wherein the volume of the concentrated herbal composition of step (4) is 10 to 15% of the total volume of the extract 1 and the extract 2.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210060665.6A CN114306519A (en) | 2022-01-19 | 2022-01-19 | A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and its preparation method |
| NL2033577A NL2033577B1 (en) | 2022-01-19 | 2022-11-21 | Traditional chinese medicine composition for heart and cerebral vessels and preparation method therefor |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210060665.6A CN114306519A (en) | 2022-01-19 | 2022-01-19 | A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and its preparation method |
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| CN114306519A true CN114306519A (en) | 2022-04-12 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1616076A (en) * | 2004-09-17 | 2005-05-18 | 朱春华 | Medicine for treating cardiocerebral vascular system disease and blood supply deficiency, medicine preparing method and preparation |
| CN103070943A (en) * | 2013-01-28 | 2013-05-01 | 西北农林科技大学 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine |
| CN105168981A (en) * | 2015-10-22 | 2015-12-23 | 河南金贵元生物科技有限公司 | Medicinal-edible homologous composition for treating three-highs (hypertension, hyperglycemia and hyperlipidaemia) and anhypnia and preparation method thereof |
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2022
- 2022-01-19 CN CN202210060665.6A patent/CN114306519A/en active Pending
- 2022-11-21 NL NL2033577A patent/NL2033577B1/en active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1616076A (en) * | 2004-09-17 | 2005-05-18 | 朱春华 | Medicine for treating cardiocerebral vascular system disease and blood supply deficiency, medicine preparing method and preparation |
| CN103070943A (en) * | 2013-01-28 | 2013-05-01 | 西北农林科技大学 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine |
| CN105168981A (en) * | 2015-10-22 | 2015-12-23 | 河南金贵元生物科技有限公司 | Medicinal-edible homologous composition for treating three-highs (hypertension, hyperglycemia and hyperlipidaemia) and anhypnia and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 廖菽丹等: "丹参葛根配方颗粒治疗420例冠心病心绞痛患者疗效观察", 《现代中医药》 * |
| 辛海: "《中药应该这样吃 家庭中药宜忌全书》", 30 June 2017 * |
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