NL2033577B1 - Traditional chinese medicine composition for heart and cerebral vessels and preparation method therefor - Google Patents
Traditional chinese medicine composition for heart and cerebral vessels and preparation method therefor Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000002490 cerebral effect Effects 0.000 title claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 32
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 14
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 14
- 235000014493 Crataegus Nutrition 0.000 claims abstract description 14
- 241001092040 Crataegus Species 0.000 claims abstract description 14
- 241000237903 Hirudo Species 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 12
- 238000002137 ultrasound extraction Methods 0.000 claims description 9
- 238000002791 soaking Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 2
- 239000003390 Chinese drug Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 12
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 11
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 230000003340 mental effect Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 36
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The present invention relates to the technical field of cardiovascular and cerebrovascular 5 drugs. The present invention provides a traditional Chinese medicine composition for heart and cerebral vessels and a preparation method therefor. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 - 35 parts of radix salviae miltiorrhizae, 15 - 20 parts of radix puerariae, 12 - 16 parts of safflowers, 2 - 6 parts of hirudo, 8 - 12 parts of herba epimedii, 13 - 17 parts of rhizoma gastrodiae and 10 - 15 parts of 10 hawthorns. The traditional Chinese medicine composition of the present invention is wide in source of raw materials and simple in preparation process, can effectively treat and prevent cardiovascular and cerebrovascular diseases without any toxic or side effect and can effectively lower mental stress and economic pressures of patients.
Description
TRADITIONAL CHINESE MEDICINE COMPOSITION FOR HEART AND CEREBRAL
VESSELS AND PREPARATION METHOD THEREFOR
The present invention relates to the technical field of cardiovascular and cerebrovascular drugs, in particular to a traditional Chinese medicine composition for heart and cerebral vessels and a preparation method therefor.
Cardiovascular and cerebrovascular diseases are a collective name for cardiovascular diseases and cerebrovascular diseases, are a kind of common diseases seriously threatening health of humans, particularly middle aged and old persons above age 50, and have the characteristics of high morbidity rate, high disability rate and high mortality. Although the currently most advanced and perfect treatment means are applied, more than 50% survivors may be dependent. There are up to 15 million persons that die from the cardiovascular and cerebrovascular diseases every year in the world, and the cardiovascular and cerebrovascular diseases are found to be the first causes of death.
With the growth in the living standard and the acceleration of life temp, diseases such as hyperlipidaemia, blood viscosity, atherosclerosis and hypertension are increased in incidence rate year by year and obviously tend to prevalent among a younger age group. Western medicine treatment focuses on dilation of blood vessels and hypotensive drugs; however, these drugs are fast in effect, but are large in side effect and easy in repeated attack; and economic pressures and mental stress are brought to patients for a long time.
An objective of the present invention is to provide a traditional Chinese medicine composition for heart and cerebral vessels and a preparation method therefor, which are capable of effectively treating and preventing cardiovascular and cerebrovascular diseases and lowering mental stress and economic pressures of patients.
In order to achieve the above objective of the present invention, the present invention provides the following technical solution:
The present invention provides the traditional Chinese medicine composition for the heart and cerebral vessels, being prepared from the following raw materials in parts by weight: 25 - parts of radix salviae miltiorrhizae, 15 - 20 parts of radix puerariae, 12 - 16 parts of 35 safflowers, 2 - 6 parts of hirudo, 8 - 12 parts of herba epimedii, 13 - 17 parts of rhizoma gastrodiae and 10 - 15 parts of hawthorns.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 28 - 32 parts of the radix salviae miltiorrhizae, 16 - 19 parts of the radix puerariae, 13 - 15 parts of the safflowers, 3 - 5 parts of the hirudo, 9 - 11 parts of the herba epimedii, 14 - 16 parts of the rhizoma gastrodiae and 11 - 14 parts of the hawthorns.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of the radix salviae miltiorrhizae, 17 - 18 parts of the radix puerariae, 14 parts of the safflowers, 4 parts of the hirudo, 10 parts of the herba epimedii, 15 parts of the rhizoma gastrodiae and 12 - 13 parts of the hawthorns.
The present invention further provides the preparation method for the traditional Chinese medicine composition, comprising the following steps of: (1) crushing raw materials, and soaking the crushed raw materials with water for 4 - 8 h to obtain a mixed material; (2) ultrasonically extracting the mixed material, and filtering an extract to obtain an extracting solution 1 and residues; (3) ultrasonically extracting the residues with water once again to obtain an extracting solution 2 and (4) combining the extracting solution 1 with the extracting solution 2, and conducting concentration to obtain the traditional Chinese medicine composition.
Preferably, in the step (1), a particle size of the crushed raw materials is 2 - 5 mm; and in the step (1), a mass ratio of the raw materials to the water is 1 to (16 - 20).
Preferably, in the step (2), a time for ultrasonic extraction is 25 - 30 min; and an ultrasonic power is 220 - 260 w.
Preferably, in the step (3), a mass ratio of the residues to the water is 1 to (10 - 15).
Preferably, in the step (3), a time for ultrasonic extraction is 15 - 20 min; and an ultrasonic power is 200 - 240 w.
Preferably, in the step (4), a volume of the concentrated traditional Chinese medicine composition is 10 - 15% of a total volume of the extracting solution 1 and the extracting solution 2.
The present invention provides the traditional Chinese medicine composition for heart and cerebral vessels and the preparation method therefor. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 - 35 parts of the radix salviae miltiorrhizae, 15 - 20 parts of the radix puerariae, 12 - 16 parts of the safflowers, 2 - 6 parts of the hirudo, 8 - 12 parts of the herba epimedii, 13 - 17 parts of the rhizoma gastrodiae and 10 - 15 parts of the hawthorns. The traditional Chinese medicine composition of the present invention is wide in source of raw materials and simple in preparation process, can effectively treat and prevent cardiovascular and cerebrovascular diseases without any toxic or side effect and can effectively lower the mental stress and the economic pressures of the patients.
The present invention provides a traditional Chinese medicine composition for heart and cerebral vessels, being prepared from the following raw materials in parts by weight: 25 - 35 parts of radix salviae miltiorrhizae, 15 - 20 parts of radix puerariae, 12 - 16 parts of safflowers, 2 -6 parts of hirudo, 8 - 12 parts of herba epimedii, 13 - 17 parts of rhizoma gastrodiae and 10 - 15 parts of hawthorns.
In the present invention, the amount of the radix salviae miltiorrhizae is preferably 28 - 32 parts by weight, and more preferably, 30 parts by weight.
In the present invention, the amount of the radix puerariae is preferably 16 - 19 parts by weight, and more preferably, 17 - 18 parts by weight.
In the present invention, the amount of the safflowers is preferably 13 - 15 parts by weight, and more preferably, 14 parts by weight.
In the present invention, the amount of the hirudo is preferably 3 - 5 parts by weight, and more preferably, 4 parts by weight.
In the present invention, the amount of the herba epimedii is preferably 9 - 11 parts by weight, and more preferably, 10 parts by weight.
In the present invention, the amount of the rhizoma gastrodiae is preferably 14 - 16 parts by weight, and more preferably, 15 parts by weight.
In the present invention, the amount of the hawthorns is preferably 11 - 14 parts by weight, and more preferably, 12 - 13 parts by weight.
The present invention further provides a preparation method for the traditional Chinese medicine composition, comprising the following steps of: (1) crushing raw materials, and soaking the crushed raw materials with water for 4 - 8 h to obtain a mixed material; (2) ultrasonically extracting the mixed material, and filtering an extract to obtain an extracting solution 1 and residues; (3) ultrasonically extracting the residues with water once again to obtain an extracting solution 2; and (4) combining the extracting solution 1 with the extracting solution 2, and conducting concentration to obtain the traditional Chinese medicine composition.
In the present invention, in the step (1), a particle size of the crushed raw materials is 2 - 5 mm, and more preferably, 3 - 4 mm.
In the present invention, in the step (1), a mass ratio of the raw materials to the water is preferably 1 to (16 - 20), more preferably, 1 to (17 - 19), and still more preferably, 1 to 18.
In the present invention, in the step (1), a soaking time is preferably 5 - 7 h, and more preferably, 6 h.
In the present invention, in the step (2), a time for ultrasonic extraction is preferably 25 - 30 min, more preferably, 26 - 29 min, and still more preferably, 27 - 28 min.
In the present invention, an ultrasonic power is 220 - 260 w, more preferably, 230 - 250 w, and still more preferably, 240 w.
In the present invention, in the step (3), a mass ratio of the residues to the water is preferably 1 to (10 - 15), more preferably, 1 to (11 - 14), and still more preferably, 1 to (12 - 13).
In the present invention, in the step (3), a time for ultrasonic extraction is preferably 15 - 20 min, more preferably, 16 - 19 min, and still more preferably, 17 - 18 min.
In the present invention, an ultrasonic power is 200 - 240 w, more preferably, 210 - 230 w, and still more preferably, 220 w.
In the present invention, in the step (4), a volume of the concentrated traditional Chinese medicine composition is preferably 10 - 15% of a total volume of the extracting solution 1 and the extracting solution 2, more preferably, 11 - 14% of the total volume of the extracting solution 1 and the extracting solution 2, and still more preferably, 12 - 13% of the total volume of the extracting solution 1 and the extracting solution 2.
The technical solutions provided by the present invention are described in detail below in combination with the embodiments, but the embodiments cannot be construed as limiting the protective scope of the present invention.
Embodiment 1 (1) Raw materials are weighed in parts by weight: 25 parts of radix salviae miltiorrhizae, 15 parts of radix puerariae, 12 parts of safflowers, 6 parts of hirudo, 12 parts of herba epimedii, 13 parts of rhizoma gastrodiae and 15 parts of hawthorns. (2) The raw materials are crushed into small pieces of 2 mm and then soaked with 16 times the mass of water for 4 h to obtain a mixed material. (3) The mixed material is ultrasonically extracted for 30 min at 220 w and then filtered to obtain an extracting solution 1 and residues. (4) 15 times the mass of water is added to the residues for ultrasonic extraction for 20 min at 200 w to obtain an extracting solution 2. (5) The extracting solution 1 and the extracting solution 2 are combined, and a mixed solution of the extracting solution 1 and the extracting solution 2 is concentrated to 15% of an original volume to obtain the traditional Chinese medicine composition.
Embodiment 2 (1) Raw materials are weighted in parts by weight: 35 parts of radix salviae miltiorrhizae, 20 parts of radix puerariae, 16 parts of safflowers, 2 parts of hirudo, 8 parts of herba epimedii, 17 parts of rhizoma gastrodiae and 10 parts of hawthorns. (2) The raw materials are crushed into small pieces of 5 mm and then soaked with 20 times the mass of water for 8 h to obtain a mixed material.
(3) The mixed material is ultrasonically extracted for 25 min at 260 w and then filtered to obtain an extracting solution 1 and residues. (4) 10 times the mass of water is added to the residues for ultrasonic extraction for 15 min at 240 w to obtain an extracting solution 2. 5 (5) The extracting solution 1 and the extracting solution 2 are combined, and a mixed solution of the extracting solution 1 and the extracting solution 2 is concentrated to 10% of an original volume to obtain the traditional Chinese medicine composition.
Embodiment 3 (1) Raw materials are weighted in parts by weight: 30 parts of radix salviae miltiorrhizae, 17 parts of radix puerariae, 14 parts of safflowers, 4 parts of hirudo, 10 parts of herba epimedii, parts of rhizoma gastrodiae and 13 parts of hawthorns. (2) The raw materials are crushed into small pieces of 3 mm and then soaked with 18 times the mass of water for 6 h to obtain a mixed material. 15 (3) The mixed material is ultrasonically extracted for 28 min at 240 w and then filtered to obtain an extracting solution 1 and residues. (4) 13 times the mass of water is added to the residues for ultrasonic extraction for 17 min at 220 w to obtain an extracting solution 2. (5) The extracting solution 1 and the extracting solution 2 are combined, and a mixed solution of the extracting solution 1 and the extracting solution 2 is concentrated to 13% of an original volume to obtain the traditional Chinese medicine composition.
Test Example 100 volunteers all with cardiovascular and cerebrovascular diseases are recruited, with 53 cases being male and 47 cases being female, aged from 51 to 73 and having courses of disease of 12 months or above. The 100 patients are randomly divided into 4 groups with 25 persons in each group. The patients are numbered as a control group and test groups 1 - 3, wherein the patients in the control group take commercial drugs for treating cardiovascular and cerebrovascular diseases following Drug Instructions; and the patients in the test groups 1-3 take the traditional Chinese medicine compositions prepared in the embodiments 1 - 3 of this application respectively, with twice every day and 80 ml each time. The test is conducted for 140 days in total. After the test is finished, a cure rate is counted, a result of which is shown in
Table 1.
Table 1
Group Initial Number of | Number of | Number of | Number of Overall number | persons improved cured persons with | effective of leaving persons persons no effect rate
Teme? | ® | 0 | 3 | wm | 2 | eek
Conclusion: the traditional Chinese medicine composition for the heart and cerebral vessels prepared in this application is wide in source of raw materials and simple in preparation process and can effectively treat and prevent cardiovascular and cerebrovascular diseases. Compared with the commercial drugs, by using the traditional Chinese medicine composition, the overall effective rate is increased by 14.7% or above; and in the follow - up duration, the patients do not reflect any adverse reaction.
From the above embodiments, the present invention provides the traditional Chinese medicine composition for heart and cerebral vessels and the preparation method therefor. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 - 35 parts of the radix salviae miltiorrhizae, 15 - 20 parts of the radix puerariae, 12 - 16 parts of the safflowers, 2 - 6 parts of the hirudo, 8 - 12 parts of the herba epimedii, 13 - 17 parts of the rhizoma gastrodiae and 10 - 15 parts of the hawthorns. The traditional Chinese medicine composition of the present invention is wide in source of raw materials and simple in preparation process, can effectively treat and prevent cardiovascular and cerebrovascular diseases without any toxic or side effect and can effectively lower the mental stress and the economic pressures of the patients.
The descriptions above are just preferred implementations of the present invention. It should be noted that several improvements and embellishments may also be made without departing from the principles of the present invention to those of ordinary skill in the art, and these improvements and embellishments should also be considered to fall within the scope of the present invention.
Claims (9)
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| CN1616076A (en) * | 2004-09-17 | 2005-05-18 | 朱春华 | Medicine for treating cardiocerebral vascular system disease and blood supply deficiency, medicine preparing method and preparation |
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| CN105168981A (en) * | 2015-10-22 | 2015-12-23 | 河南金贵元生物科技有限公司 | Medicinal-edible homologous composition for treating three-highs (hypertension, hyperglycemia and hyperlipidaemia) and anhypnia and preparation method thereof |
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| CN1616076A (en) * | 2004-09-17 | 2005-05-18 | 朱春华 | Medicine for treating cardiocerebral vascular system disease and blood supply deficiency, medicine preparing method and preparation |
Non-Patent Citations (1)
| Title |
|---|
| KUMAR KSHITIZ ET AL: "Ultrasound assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: A review", ULTRASONICS SONOCHEMISTRY, BUTTERWORTH-HEINEMANN, GB, vol. 70, 1 September 2020 (2020-09-01), XP086365538, ISSN: 1350-4177, [retrieved on 20200901], DOI: 10.1016/J.ULTSONCH.2020.105325 * |
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