CN102218084B - Traditional Chinese medicament health preserving preparation having effects of enhancing immunity, resisting ageing and improving sub-health - Google Patents
Traditional Chinese medicament health preserving preparation having effects of enhancing immunity, resisting ageing and improving sub-health Download PDFInfo
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- CN102218084B CN102218084B CN2011101517952A CN201110151795A CN102218084B CN 102218084 B CN102218084 B CN 102218084B CN 2011101517952 A CN2011101517952 A CN 2011101517952A CN 201110151795 A CN201110151795 A CN 201110151795A CN 102218084 B CN102218084 B CN 102218084B
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Abstract
The invention discloses a traditional Chinese medicament health preserving preparation having effects of enhancing immunity, resisting ageing and improving sub-health. The preparation consists of the active ingredients of ethanol extracts of propolis (EEP), extracts of ganoderma lucidum and fermented bacterial powder of paecilomyces hepiali, and can be prepared into capsules, tablets or pills. The preparation is based on the traditional Chinese medicament health preserving theory and combines the modern medical research, replenishes insufficient yin and yang, qi and blood, body fluid and the like of human body by supporting right and banking up the root in the traditional Chinese medicament theory, improves the immunologic function of human body, balances yin and yang of organisms and fully replenishes qi and blood so as to improve the disease-resisting ability of organisms, improve the sub-health symptoms and enhance the anti-ageing effect of organisms. The invention also discloses a method for preparing the preparation.
Description
Technical field
The present invention relates to Chinese medicine preparation, be specifically related to a kind of Chinese medicine health preserving preparation.
Background technology
Sneak into the armaticity jelly that the secretions of body of gland such as its mandibular gland and Cera Flava etc. process behind the propolis resin-like secretions that to be worker bee collect from tissues such as the newborn branch of plant, leaf, bud or barks.Propolis has effects such as anti-inflammation, enhance immunity.The chemical constituent of propolis is very complicated, and therefrom the composition that goes out of isolation identification has flavonoid, terpenes, quinones, esters, alcohols, phenols, ethers, organic acid and a large amount of aminoacid, enzyme, vitamin Bs
1, vitamin B
2, vitamin B
6, vitamin E and vitamin A and mineral etc.According to " China's book on Chinese herbal medicine " record, propolis has good auxiliary treatment effect to the disease that diabetes, hyperlipidemia, hypertension, tumor, multiple inflammation, pathogenic bacteria etc. cause.Plan is by the inside the plan a kind of health product of World Health Organization's nutrition and health care.
Ganoderma, another name " Umbillcaria esculenta ", ancient claim " Ganoderma " is commonly called as " Herba mesonae chinensis " " Herba Hylothelephii Verticillati ".Chinese tradition medical science is regarded it as strengthening by means of tonics for a long time always, is consolidated the precious Chinese herbal medicine of setting upright.In the Shennong's Herbal in the Eastern Han Dynasty last years of a dynasty or reign Ganoderma was classified as top gradely before bimillennium, thought " food, it is not old to make light of one's life by commiting suicide, life lengthening " for a long time.Pair Ganoderma property of medicine is all arranged in Compendium of Material Medica that Ming Dynasty's Li Shizhen (1518-1593 A.D.) is write and the later ancient books and records thereof, cure mainly the record with function, think that Ganoderma has strengthening by means of tonics, life lengthening, sharp joint, controls effects such as deafness.
The peacilomyce hepiahi zymophyte powder is an isolating cordyceps species from fresh natural cs, the artificial Cordyceps (Paecilomyces hepiali Chen et Dai Mycelia) that utilizes modern bio-fermentation engineering to produce.
Disclose a kind of health food that contains the enhancing immunity of propolis, Ganoderma extract and Cordyceps mycelium in Chinese patent CN100420448C, wherein the weight portion of propolis, Ganoderma extract and Cordyceps mycelium is respectively 50-60,30-40 and 5-15 part.Disclose the Chinese medicine preparation of blood sugar regulation, immunity in Chinese patent CN1660388A, it contains propolis 20-50%, Ganoderma 20-60%, Cordyceps 10-30% (percentage by weight).
The inventor finds that the function of the part by weight gained Chinese medicine preparation of adjusting propolis, Ganoderma extract and Cordyceps mycelium has remarkable different on the basis of research for many years.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation that has enhancing immunity, defying age and improve the subhealth state effect, the active ingredient of this Chinese medicine preparation is propolis ethanol extraction, Ganoderma extract and peacilomyce hepiahi zymophyte powder, its weight ratio is 5-3: 1-2: 1-2, further preferred 3: 1: 1.
Another object of the present invention provides a kind of method for preparing described Chinese medicine preparation.
1, propolis ethanol extraction:
Former propolis heating wax removing, temperature must be controlled in 70 degree, and is unaffected to guarantee active substance.Pulverize the back and soak, the former propolis after being about to pulverize is delivered to and is soaked the workshop, is that 95% edible ethanol places mixing jar immersion 30 days with percent by volume.Started mixing machine every 3 days between soak period and rotated 45 minutes, the active substance of former propolis is fully dissolved.Filter, soak overdue raw material and deliver to filtration plant, carry out filtering and impurity removing with 300 purpose filters.Filtrate stores with the packing container of handling through sterilization.Propolis solution after filtering is precipitated 7 days with being pumped in the retort, and stir 2 preceding 3 day every day, stirred back 4 days quiescent settings 15 minutes at every turn.The propolis solution of post precipitation carries out deleading with absorption method and handles, and lead content must not surpass 1ppm.Propolis liquid behind the deleading was placed 5 days to clarification plant.The propolis clear liquor is centrifugal to cascade filtration workshop (sterile workshop), and filters with 500 purpose filters.Get propolis fine straining liquid in the cryoconcentration jar, temperature is controlled at 60-70 degree centigrade in jar, and pressure is 0.08MPa, ethanol is evaporated fully, and ethanol is reclaimed.The ethanol extraction index is not less than 98.0%.
2, peacilomyce hepiahi zymophyte powder
White sugar, soyabean expeller, peptone, glucose, potassium dihydrogen phosphate, magnesium sulfate, defoamer, Oleum Glycines are tested, and eligible stores, after pulverizing, stirring, and part preparation seed culture medium, another part preparation fermentation culture material.Seed culture medium is inoculated into the peacilomyce hepiahi bacterium kind of acceptance(check) on the seed culture medium in the rearmounted seed tank of high-temperature high-voltage sterilizing sterilizing, carries out the shaking table constant temperature culture; The fermentation culture material is put and is carried out fermentation culture in the fermentation tank behind high-temperature high-voltage sterilizing sterilizing; Then inoculum is filtered with fermentation culture medium, after the operations such as drying, pulverizing promptly.
3, Ganoderma extract
Ganoderma sporophore is crossed 20 mesh sieves after crushed, gets the Ganoderma coarse powder; The Ganoderma coarse powder is decocted 2 times, add 10 times of water gagings at every turn, decocted 2 hours; Twice decoction liquor filtered, merge, get filtrate; Filtrate under 70 ℃ of conditions, is carried out concentrating under reduced pressure with centrifugal-film evaporator, to the concentrated solution relative density be 1.1; Adding 4 times of amount percents by volume is that 95% ethanol carries out precipitate with ethanol, leaves standstill 24 hours, filters, and gets the precipitate with ethanol precipitate; Add 10 times of amount purified water and in the interlayer heating kettle, dissolve, get medicinal liquid; Medicinal liquid is carried out spray drying, get dry powder; Dry powder is sieved, get Ganoderma extract, ganoderan 〉=20% (weight).
With propolis ethanol extraction, peacilomyce hepiahi zymophyte powder and Ganoderma extract mixed with 5-3: 1-2: 1-2, add the adjuvant that pharmaceutically allows, be prepared as tablet, granule, capsule, oral liquid, syrup, pill etc.
Chinese medicine preparation of the present invention resists oxidasic vigor and has remarkable potentiation, can have defying age and the effect of improving subhealth state.
The specific embodiment
Embodiment 1
Propolis ethanol extraction 120 grams
Ganoderma extract 40 grams
Peacilomyce hepiahi zymophyte powder 40 grams
Propolis ethanol extraction, Ganoderma extract, peacilomyce hepiahi zymophyte powder are crossed 80 mesh sieve mixing for standby use.
Embodiment 2
Propolis ethanol extraction 55 grams
Ganoderma extract 35 grams
Peacilomyce hepiahi zymophyte powder 10 grams
Propolis ethanol extraction, Ganoderma extract, peacilomyce hepiahi zymophyte powder are crossed 80 mesh sieve mixing for standby use.
Embodiment 3
Propolis ethanol extraction 50 grams
Ganoderma extract 40 grams
Peacilomyce hepiahi zymophyte powder 10 grams
Propolis ethanol extraction, Ganoderma extract, peacilomyce hepiahi zymophyte powder are crossed 80 mesh sieve mixing for standby use.
Embodiment 4
Propolis ethanol extraction 60 grams
Ganoderma extract 20 grams
Peacilomyce hepiahi zymophyte powder 5 grams
Propolis ethanol extraction, Ganoderma extract, peacilomyce hepiahi zymophyte powder are crossed 80 mesh sieve mixing for standby use.
Embodiment 5
Adopt the thing that tried of embodiment 1 to carry out antioxidation (anti-aging effects) test
(1) material and method
It is 1.2g/60kgBW that embodiment 1 is tried thing human body day recommended intake, is that subjects is established three dosage groups with the mice, is respectively: 0.10g/kgBW, 0.20g/kgBW, 0.40g/kgBW promptly are equivalent to 5,10,20 times of human intaking amount respectively.
Experimental technique (bromobenzene modelling):
50 of SPF level Kunming kind female mices are divided into 5 groups (1 blank group, 1 model control group and 3 dosage groups) at random.3 dosage group per os give the given the test agent of variable concentrations, model control group gives the equal-volume distilled water, continue to get after 30 days blood and survey antioxidase activity, after this animal hunger is spent the night to given the test agent after 1 hour, each group is irritated stomach 0.3mg/kgBW bromobenzene oil (irritating stomach amount 0.1ml/10gBW) except that the blank group, and the execution animal is got hepatic tissue and measures lipid peroxide content and antioxidase activity after 22 hours.
(2) mice MDA, SOD, GSH-PX influenced result's (seeing Table 1,2,3):
After per os gave this product of various dose, SOD before the modeling in the middle and high dosage group blood and the vigor of GSH-PX all were higher than model control group, and difference has significance (P＜0.05).The MDA content of middle and high dosage group liver homogenate all is lower than model control group after the modeling, and difference has significance (P＜0.05); The SOD vigor and the GSH-PX vigor of basic, normal, high dosage group liver homogenate all are higher than model control group, and difference has significance (P＜0.05).Prompting embodiment 5 is tried thing and is had clear and definite anti-oxidation function (anti-aging effects).
The influence of table 1 couple SOD, GSH-PX (before the modeling, blood)
The influence of table 2 couple SOD, MDA (after the modeling, liver homogenate)
The influence of table 3 couple GSH-PX (after the modeling, liver homogenate)
Embodiment 6
Different proportionings are tried antioxidation (anti-aging effects) test of thing
Tried the influence of thing to antioxidation according to embodiment 5 described method test implementation example 2-4, the result is as follows
Table 4 embodiment 2 is tried the influence (modeling before, blood) of thing to SOD, GSH-PX
Table 5 embodiment 2 is tried the influence (modeling after, liver homogenate) of thing to SOD, MDA
Table 6 embodiment 2 is tried the influence (modeling after, liver homogenate) of thing to GSH-PX
Table 7 embodiment 3 is tried the influence (modeling before, blood) of thing to SOD, GSH-PX
Table 8 embodiment 3 is tried the influence (modeling after, liver homogenate) of thing to SOD, MDA
Table 9 embodiment 3 is tried the influence (modeling after, liver homogenate) of thing to GSH-PX
Table 10 embodiment 4 is tried the influence (modeling before, blood) of thing to SOD, GSH-PX
Table 11 embodiment 4 is tried the influence (modeling after, liver homogenate) of thing to SOD, MDA
Table 12 embodiment 4 is tried the influence (modeling after, liver homogenate) of thing to GSH-PX
From the result of embodiment 6, propolis, Ganoderma extract are different with the weight proportion of peacilomyce hepiahi zymophyte powder, its effect difference in antioxidation.In the specified weight ratio range, can bring into play collaborative potentiation between propolis, Ganoderma extract and the peacilomyce hepiahi zymophyte powder, to further studies show that of weight proportion, the optimum weight proportioning of propolis ethanol extraction, Ganoderma extract and peacilomyce hepiahi zymophyte powder is 5-3: 1-2: 1-2, outside this scope, its antioxidation weakens.
Claims (2)
1. one kind has the antioxidative Chinese medicine preparation, and the active ingredient of described preparation is made up of propolis ethanol extraction, Ganoderma extract and peacilomyce hepiahi zymophyte powder, and its weight ratio is 3: 1: 1; Wherein the propolis ethanol extraction is to obtain by the following method: former propolis heating wax removing, temperature is controlled in 70 degree, unaffected to guarantee active substance, pulverizing the back soaks, be that 95% edible ethanol places the mixing jar to soak 30 days promptly with percent by volume, starting mixing machine every 3 days between soak period rotated 45 minutes, the active substance of former propolis is fully dissolved, filter, soak overdue raw material and deliver to filtration plant, carry out filtering and impurity removing with 300 purpose filters, filtrate stores with the packing container of handling through sterilization, propolis solution after filtering is precipitated 7 days with being pumped in the retort, stir 2 preceding 3 day every day, the each stirring 15 minutes, the 4 days quiescent settings in back, the propolis solution of post precipitation carries out deleading with absorption method and handles, lead content must not surpass 1ppm, propolis liquid behind the deleading was placed 5 days to clarification plant, and the propolis clear liquor is centrifugal to the cascade filtration workshop, and filters with 500 purpose filters, propolis fine straining liquid is in the cryoconcentration jar, temperature is controlled at 60-70 degree centigrade in jar, and pressure is 0.08MPa, and ethanol is evaporated fully, and ethanol reclaimed, the alcohol extract index is not less than 98.0%; The peacilomyce hepiahi zymophyte powder is to obtain by the following method: white sugar, soyabean expeller, peptone, glucose, potassium dihydrogen phosphate, magnesium sulfate, defoamer, Oleum Glycines are tested, eligible stores, after pulverizing, stirring, part preparation seed culture medium, another part preparation fermentation culture material, sub-culture medium is inoculated into the peacilomyce hepiahi bacterium kind of acceptance(check) on the seed culture medium in the rearmounted seed tank of high-temperature high-voltage sterilizing sterilizing, carries out the shaking table constant temperature culture; The fermentation culture material is put and is carried out fermentation culture in the fermentation tank behind high-temperature high-voltage sterilizing sterilizing; Then inoculum is filtered with fermentation culture medium, behind drying, the pulverizing process promptly; Ganoderma extract is to obtain by the following method: Ganoderma sporophore is crossed 20 mesh sieves after crushed, gets the Ganoderma coarse powder; The Ganoderma coarse powder is decocted 2 times, add 10 times of water gagings at every turn, decocted 2 hours, twice decoction liquor filtered, merge, get filtrate; Filtrate under 70 ℃ of conditions, is carried out concentrating under reduced pressure with centrifugal-film evaporator, to the concentrated solution relative density be 1.1; Adding 4 times of amount percents by volume is that 95% ethanol carries out precipitate with ethanol, leaves standstill 24 hours, filters, and gets the precipitate with ethanol precipitate, adds 10 times of amount purified water and dissolves in the interlayer heating kettle, gets medicinal liquid; Medicinal liquid is carried out spray drying, get dry powder, dry powder is sieved, get Ganoderma extract.
2. Chinese medicine preparation as claimed in claim 1, described preparation are tablet, granule, capsule, oral liquid, syrup, pill.
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| CN105709146A (en) * | 2014-03-07 | 2016-06-29 | 陈西成 | Qi-tonifying nerve-calming electuary for treating acute heart failure |
| CN105816765A (en) * | 2014-03-07 | 2016-08-03 | 陈西成 | Vital energy-replenishing and nerve-calming granules for acute heart failure and preparation method for granules |
| CN105749086A (en) * | 2014-03-07 | 2016-07-13 | 陈西成 | Qi invigorating and tranquilization electuary for treating acute heart failure |
| CN105770649A (en) * | 2014-03-07 | 2016-07-20 | 陈西成 | Method for preparing qi-invigorating and nerve-calming granules for acute heart failure |
| CN104839689A (en) * | 2015-04-21 | 2015-08-19 | 吉林大学珠海学院 | Health product for invigorating spleen, nourishing stomach, resisting fatigue and enhancing immunity |
| CN108719773A (en) * | 2018-05-31 | 2018-11-02 | 张顺兴 | A kind of glossy ganoderma powder and preparation method thereof |
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| CN100420448C (en) * | 2005-11-25 | 2008-09-24 | 南京中科集团有限公司 | Health-care food with function for improving immunity and its prepn. method |
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Address after: 101100, No. 2, building 58, 25 Xinhua West Street, Beijing, Tongzhou District, 2523 Patentee after: Huaxia Xianbao (Beijing) Traditional Chinese Medicine Research Institute Co., Ltd. Address before: 101121 Beijing city Tongzhou District Cloud Road No. 432 0706 Patentee before: Huaxia Xianbao (Beijing) Traditional Chinese Medicine Research Institute Co., Ltd. |