CN107050154A - It is a kind of to treat outer bath anaesthetic of gout and preparation method thereof - Google Patents

It is a kind of to treat outer bath anaesthetic of gout and preparation method thereof Download PDF

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CN107050154A
CN107050154A CN201710250735.3A CN201710250735A CN107050154A CN 107050154 A CN107050154 A CN 107050154A CN 201710250735 A CN201710250735 A CN 201710250735A CN 107050154 A CN107050154 A CN 107050154A
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gout
externally used
mongolian medicine
medicine
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奥乌力吉
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract

It is the present invention relates to a kind of medicine, i.e., a kind of to treat outer bath anaesthetic of gout and preparation method thereof.A kind of externally used Mongolian medicine for treating gout is provided, is characterized in：The externally used Mongolian medicine of the treatment gout is made up of the bulk drug of following parts by weight：3-5 parts of the red sage root, 1-3 parts of safflower, 1-3 parts of plantain seed, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine, its preparation method is：The raw material is ground into coarse powder, coarse powder is impregnated with 65~75% ethanol, is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs are extracted 2~4 times at a temperature of 60~80 DEG C, merges extract solution, concentrates, dry, obtain extract.Beneficial effect is：The advantage bathed outside anaesthetic is maintained, is had no toxic side effect, can be long lasting for using, instant effect, symptoms last mitigates, until the state of an illness is controlled.And prepare simply, it is with low cost, it is easy to use, bring Gospel to patient with gout.

Description

It is a kind of to treat outer bath anaesthetic of gout and preparation method thereof
Technical field
It is the present invention relates to a kind of medicine, i.e., a kind of to treat outer bath anaesthetic of gout and preparation method thereof.
Background technology
Gout is a kind of frequently-occurring disease, all over the world, economic rich countries and regions, and the incidence of disease is higher. There is joint bone deformation in the joint such as patient with gout brothers constant pain, severe one.It has been established that, gout Hyperuricemia, HUA is a kind of because biosynthesis of purine is metabolized increase, and uric acid produces excessive or causes uric acid liter in blood because uric acid excretion is bad Height, urate crystal is deposited in synovium of joint, synovial bursa, cartilage and its hetero-organization caused repeated relapsing inflammatory disease.To the greatest extent The origin cause of formation of pipe gout is clear and definite, but it treats difficulty still very greatly, or even be considered as irreversible life-long disease.It is existing The medicine for treating gout is a lot, for example:In medical bark of ash, golden cypress, YANHUSU, the radix paeoniae rubrathe, river ox paint, rhizoma alismatis, plantain seed, smilax Etc. the TONGFENGDING being made, the gout being made of rheum officinale, plantain seed, rhizoma alismatis, radix cyathulae, root of fangji etc. is relaxed；Doctor trained in Western medicine colchicin or Indomethacin is relieved pain, and uses probenecid（Benemid）Increase kidney uric acid excretion etc., all with certain curative effect.But, due to Can not effect a radical cure, can only maintaining treatment, thus need Long-term taking medicine.And there is toxic side effect existing medicine more, it is unsuitable for long-term clothes With thus limit the therapeutic effect of gout.
Treatment of the Mongolian medicine to gout has the medicinal bath therapy that rich experience, particularly Mongolian medicine commonly use, can be from outside work For affected part, mitigate the pain of patient.Because outer bath is not by interior internal organs, toxic side effect is greatly reduced, thus can be used for a long time. But, due to lacking in-depth study, many medicated bath prescriptions are only spread in the form of secret recipe among the people, it is impossible to be widely applied, It is even a large amount of lost.Minority charges to the prescription of ancient books and records, and its is of the remote past, and technique is single, and therapeutic action is anxious by certain limitation It need to be improved with modern means of science and technology.
The content of the invention
The purpose of the present invention is on the basis of arrangement anaesthetic traditional herbal medicine is collected, with Mongolian medicine's theory to instruct, to use for reference now Generation technique means, proposition is a kind of evident in efficacy to gout, and human body is had no toxic side effect, can be long lasting for using, and curative effect is steady It is fixed, it is difficult repeatedly, and prepare simple, cheap externally used Mongolian medicine and preparation method thereof.
Above-mentioned purpose is realized by following technical scheme：A kind of externally used Mongolian medicine for treating gout is provided, is characterized in：Institute The externally used Mongolian medicine for stating treatment gout is made up of the bulk drug of following parts by weight：3-5 parts of the red sage root, 1-3 parts of safflower, plantain seed 1-3 parts, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine.
The weight of the bulk drug is：4 parts of the red sage root, 2 parts of safflower, 2 parts of plantain seed, 4 parts of the Bi roots of grass, 4 parts of cape jasmine.
The weight proportion of the bulk drug is：Red sage root 10g, safflower 5g, plantain seed 5g, Bi roots of grass 10g, cape jasmine 10g.
The raw material medicaments in part by weight adds 3-5 parts of Echinops latifolius, single 4-6 parts of leaf pseudo-ginseng, 5-7 parts of Androsace umbellata.
The raw material medicaments in part by weight adds 2-4 parts of pseudo-ginseng, 3-5 parts of the bark of eucommia, 3-5 parts of loud, high-pitched sound cloth knot.
The raw material medicaments in part by weight adds 1-3 parts of Echinops latifolius, single 1-3 parts of leaf pseudo-ginseng, 2-4 parts of Androsace umbellata, pseudo-ginseng 1-3 parts, 1-4 parts of the bark of eucommia, 1-4 parts of loud, high-pitched sound cloth knot.
The preparation method of externally used Mongolian medicine of the treatment gout is：The bulk drug was crushed and more than 80 mesh sieved, packaging It is standby.
The preparation method of externally used Mongolian medicine of the treatment gout is：The raw material is ground into coarse powder, with 65~75% Coarse powder is impregnated with by ethanol, is reloaded into continuous circumfluence extraction device, at a temperature of 60~80 DEG C 65~75% alcohol refluxs extract 2~ 4 times, merge extract solution, concentrate, dry, obtain extract.
The preparation method of externally used Mongolian medicine of the treatment gout is：The raw material is respectively crushed into coarse powder, car therein Coarse powder is impregnated with by preceding son, the Bi roots of grass, cape jasmine with 65~75% ethanol, is reloaded into continuous circumfluence extraction device, in 60~80 DEG C of temperature Lower 65~75% alcohol refluxs of degree are extracted 2~4 times；The red sage root therein, safflower ethyl acetate soak extraction；Said extracted liquid Merge concentration, dry, obtain extract.
The preparation method of externally used Mongolian medicine of the treatment gout is：The raw material is respectively crushed into coarse powder, with 65~ Coarse powder is impregnated with by 75% ethanol, is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs at a temperature of 60~80 DEG C Extract 2~4 times；Filter residue petroleum ether soak extraction；Said extracted liquid is merged concentration, dried, extract is obtained.
The application method of externally used Mongolian medicine of the treatment gout is：The medicine is put in bath water, 38-45 DEG C of water temperature, Soak affected part, every time about 20-90 minutes.
The beneficial effects of the invention are as follows：Maintain the advantage bathed outside anaesthetic, have no toxic side effect, can long lasting for using, Instant effect, symptoms last mitigates, until the state of an illness is controlled.And prepare simply, it is with low cost, it is easy to use, to patient with gout Bring Gospel.
Embodiment
The first embodiment, takes the bulk drug of following parts by weight by weight：3-5 parts of the red sage root, 1-3 parts of safflower, Chinese herbaceous peony 1-3 parts of son, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine.Its preferred weight part is matched：4 parts of the red sage root, 2 parts of safflower, 2 parts of plantain seed, 4 parts of the Bi roots of grass, 4 parts of cape jasmine.Clinical practice single dose weight proportion is preferred：Red sage root 10g, safflower 5g, plantain seed 5g, Bi roots of grass 10g, cape jasmine 10g。
Concocting method is：The bulk drug was crushed more than 80 mesh sieve into it is powdered.
Usage and dosage：Outer bath.Above-mentioned powder is taken, is put in appropriate more than 90 DEG C hot water, 40 DEG C or so of water temperature is kept, trouble Portion is generally that brothers are not immersed in the water, and immersion every time is no less than 20 minutes, and soak time is resistant to be limited with patient skin, typically Up to 1.5 hours, according to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.
Bulk drug brief introduction.
The red sage root also known as red ginseng, radix salviae miltiorrhizae, red root etc., Chinese medicine name is labiate red sage root Salvia miltiorrhiza Bge. dry root and rhizome.It is main to contain fat-soluble Diterpenoids from bulbus and water miscible phenolic acid components, also containing flavonoids, triterpene Class, the other compositions such as sterol.In liposoluble constituent, category quinone, ketone type structure have：The A of tanshinone (tanshinone) I, II, II B [1,2], V, VI, Cryptotanshinone (cryptotanshinone), the B of isotanshinone (isotanshinone) I, II, II, different hidden pellet Join ketone (isocryptotanshi-none), the A of hydroxyl tanshinone (hydroxytanshinone) II, saivianic acid A acid (methyl Tanshinonate), it is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness that clears away heart-fire, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen Hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
Safflower, FlosCarthami.（English）Safflower is also known as safflower.For feverfew safflower Carthamus Tinctorius L. tubular corolla.Safflower oil content is high, is a kind of emerging oil crops.Safflower oil is up to containing linoleic acid 73-80%, is a kind of good drying oil；Without leukotrienes, suitable for production alkyd resin, 20-30% containing uranidin in spending, containing red Protein content is 19% in pigment 0.3-0.6%, band shell grouts, and cake protein matter of shelling content is 36%.Safflower tool is special fragrant Gas, it is warm-natured, it is pungent, can invigorate blood circulation, blood stasis removing analgesic.It is used for Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, traumatic injury, Sore swell and ache curative.
Chinese herbaceous peony, Plantago asiatica also known as:Asiatic plantain, five grass, wheel dish, Chinese herbaceous peony seed peach jaurel containing the moon Glucoside（aucubin）, Chinese herbaceous peony mucopolysaccharide（plantago-mulilage）, racemization-plantagoside（plantago-side）, all square rafters Glucoside acid（geniposidic acid）, plantenolic acid（plantenolic acid）, butanedioic acid（succinic acid）, gland is fast Purine（adenine）, choline（choline）And 10.43% fat oil, cupreol（β-sitosterol）, cupreol -3- O- β-D- glucopyanosides（β-sitosteryl-3-O-β-D-glucopyranoside）.With antidiarrheal, diuresis, eliminating the phlegm, Antibechic, the effect of relievining asthma etc..Nature and flavor：It is sweet；It is light；Cold nature.Function：Reducing fever and causing diuresis；Excreting dampness antidiarrheal；Improving eyesight；Eliminating the phlegm.Cure mainly：Master is small Just it is unfavorable；Under stranguria with turbid discharge band；Oedema turgor；Summer-heat and damp rush down dysentery；Hot eyes is hidden from view；The hot cough and asthma of phlegm.
Bi is dialled, Piper longum Linn. alias:Bi Bo, Bi roots of grass, piper longum, Bi are dialled, Piperaceae, Piper.Bi roots of grass fruit It is real to contain pipering（piperine）, palmitic acid（Palmiticacid), tetrahydropiperic acid （TeTCMLIBahydropipericacid), 11 carbon -1- alkene -3,4- methylene dioxy benzene（L-undecylenyl-3,4- methylene-dioxybenzene）, piperidines（piperine）, volatile oil, the anti-4- acid amides of N- isobutyl groups decadinene-anti-2-（N- isobutyldeca-TCMLIBans-2-TCMLIBans-4-dienamide）, sesamin（sesamin）, Bi roots of grass nonadiene piperazines Pyridine（pipernonaline）, the carbon triolefin piperidines of the Bi roots of grass 11（piperun-decalidine）, the bright peaceful alkali of the Bi roots of grass （piperlonguminine）, the bright peaceful alkali of the dihydro Bi roots of grass（di-hydropiperlonguminine）, piperamide （pipercide）, Guinea's piperamide（guineensine）, carbon -2, the 4- diene amide of N- isobutyl groups 18（N- isobutyloc-tadeca-2（E）, 4（E）- dienamide), carbon -2, the 4- diene amide ［ N- of N- isobutyl groups 20 isobutyleicosa-2（E）, 4（E）- dienamide ］, the carbon -2,4 of N- isobutyl groups 20, the acrylamide ［ N- of 8- tri- isobutyleicosa-2（E）, 4（E）, 8（Z）- TCMLIBienamide ］, Bi roots of grass nonyl triolefin piperidines （dehydropipernonaline）, stem is containing piplartine（piplar-tine,piperlongumine）.Contain long handle in seed Pipering（sylvatine）, double different Eudesmins（Diaeudesmin ］.Fruit ear is used as medicine, nature and flavor：It is pungent, heat.Function：Warming spleen and stomach for dispelling cold, Lower gas analgesic.Cure mainly：For coldness and pain in the epigastrium, vomiting, diarrhea, antimigraine, nasosinusitis, toothache, coronary heart diseases and angina pectoris are controlled outside.
Cape jasmine（Scientific name：Gardenia jasminoides Ellis）Alias：Yellow Fructus Gardeniae, stir-baked FRUCTUS GARDENIAE, mountain Cape jasmine, white toad, be The fruit of madder wort cape jasmine, constituents containing iridoid：Gardenoside (gardenoside), all square rafter glucoside (geniposide), all square rafter (genipin-1-gentiobioside), shanzhiside (shanzhiside), Cape jasmine ketone glucoside (gardo-side), Chinese Fevervine Herb time glucoside methyl esters (scandoside methyl ester), all square rafter glucoside (geniposidic acid), deacetylate asperuloside acid (deacetyl asperulosidic acid), removes acetyl Propeller Blade The sour methyl esters (methyl deacetyl asperulosidate) of careless glucoside, 10- acetyl group all square rafter glucosides (10- Acetylgeniposide) 6 〃-to coumaric acyl all square rafter (6 〃-p-coumaroyl genipin gentiobio-side).Contain acrylic component again：Chlorogenic acid (chlorogenic acid), 3,4- bis--O- caffeoyls its quininic acids (3, -4-di-O-caffeoyl quinic acid), 3-O- coffee acyl -4-O- mustard acyl quininic acids (3-O- Caffeoyl-4-O-sinapoyl quinic acid), 3,5- bis--O- coffee acyls -4-O- (methyl of 3- hydroxyls -3) glutaryl Base quininic acid [3,5-di-O-caffeoyl-4-O- (3-hydroxy-3-methyl) glutaroyl quinic acid], 3, Coffee acyl-the 5- of 4- bis- (3- hydroxy-3-methyl glutaryls base) quininic acid [3,4-dicaffeovl-5- (3-hydroxy-3- Methyl glutaroyl) quinic acid], crocetin (cro-cetin), crocin (crocin), ursolic acid (ursolic acid), crocin glycoside (crocin glucoside) etc..Also contain flavones ingredient：Rutin (rutin) and PEARLITOL 25C (D-mannitol), cupreol (β-sitosterol), choline (choline), nonacosane (nonacosane), lutein (xanthophyll) etc..Also gardenoside, all square rafter glucoside, all square rafter glucoside are contained in pericarp and seed Acid, all square rafter.Flower contains Triterpenoid：Gardenia acid (gradenlic acid) A, B and gardenia acid (gardenic acid) leaf contains gardenoside, all square rafter glucoside, cape jasmine aldehyde (cerbinal), MDJ (methyl Dihydrojasmonate), acetic acid benzyl lemon imonene (limonene), linalool (linalool) etc..Rhizome contains PEARLITOL 25C, olive Sour (oleanolic acid), stigmasterol (sing-masterol).Smell：It is bitter, cold, nontoxic, belong to heat-clearing and fire-clearing drug, can purging intense heat Relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis.With the effect such as protect liver, cholagogic, decompression, calmness, hemostasis, detumescence, the traditional Chinese medical science Clinic is usually used in the diseases such as treatment icteric hepatitis, bruise, hypertension, diabetes.
Experiment Introduction：
1. screening experiment：Mongolian medicine thinks that gout is in a kind of common disease that extremities joint pain caused by heat evil is main symptom, human body Yellow water, which increases, to be contained, with " association's day（Heat）" and blood hand over fight involve joint, it is local conspicuous according to（Gas）It is cause gout main that blood operation, which is obstructed, The cause of disease.Therefore with blood circulation and channel invigorating, clearing and activating the channels and collaterals, wind-dispelling relaxing muscles and tendons, anti-inflammatory analgetic is principle of reatment.It is logical to invigorate blood circulation from the red sage root, safflower It is arteries and veins, clearing and activating the channels and collaterals, from plantain seed, cape jasmine Xiaohuangshui, to association's day（Heat）, anti-inflammatory analgetic, wind-dispelling relaxing muscles and tendons, select the Bi roots of grass dredge gas Blood, warming spleen and stomach for dispelling cold, lower gas analgesic.
Focus in view of gout is generally brothers end, and needs long-time medication, therefore selection Mongolian medicine continues to use the medicine of thousand Balneotherapy.Permeate and guide drugs to illness station by soaking to medicine, improve whole body it is conspicuous according to（Gas）Blood operation conditions, reach it is promoting blood circulation and removing blood stasis, Clearing and activating the channels and collaterals, promoting qi circulation and relieving pain purpose.
Clinical trial
Reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, Sun Chuanxing edits in People's Medical Officer Press）, with reference to The particularity of the present invention, formulates clinical criteria of the present invention and treatment standard.
Diagnostic criteria：
Diagnostic criteria：Duo You families gout medical history or related history, including 1 type glycogen storage disease, myeloproliferative disease, cancer Uric acid generation increases after chemicotherapy, chronic kidney disease, uric acid discharge the medical histories, oral thiazide diuretic, frusemide, ethamine such as reduction Butanol etc. suppresses tubular secretion uric acid and discharges the pharmacohistories such as reduction；Often there are heating, chilly, powerless, headache, apocleisis, joint Bitterly, affected joints are common with thumb, Metatarsophalangeal joint, are secondly ankle, hand, wrist, knee, elbow, foot, and joint is red, swollen, hot, pain, Limitation of activity, local skin furfur or itch, arthroedema, joint deformity；Blood leukocytes number increases, and erythrocyte sedimentation rate is speeded, blood urine Acid increases.The person that has urate calculi, has renal colic, blood urine, intermittent proteinuria, specific gravity of urine low, blood urea nitrogen rise, in urine Uric acid content increases；Tophus is formed, helix, anthelix, plantar toe, refer between, metacarpophalangeal portion it is common, tophus can be arranged through skin diabrosis Go out white urate crystal；The visible affected joints of X-ray film have circular or irregular sample of giving a farfetched interpretation in the sclerotin of bone edge adjacent joints Bright defect, pyelography visible light-transmissive kidney stone；With rheumatic arthritis, rheumatoid arthritis, pyogenic arthritis, Traumatic arthritis mutually differentiates.
Treatment standard：Cure：Symptom disappears, and uric acid content is normal in blood and urine, normal renal function, and more than 2 years without multiple Hair.Take a turn for the better：In the case of medication, remission.Blood and urine uric acid content are close to normal, renal function improvement, and nothing is multiple in 1 year Hair.It is invalid：Do not react or do not improved through two courses for the treatment of through a course of therapy, especially exacerbation of symptoms person.
Patient 40, experimental group 20 is treated with this dipping, and 7 days as one therapeutic course is limited with two courses for the treatment of, application method It is：This product is put in bath water, 38-45 DEG C of water temperature, soaks affected part, every time about 20-90 minutes.
Control group 20, is treated with oral traditional Chinese medicine TONGFENGDING.It the results are shown in Table 1.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy gout is substantially better than the curative effect of TONGFENGDING, and therapeutic effect is notable.
Second of embodiment, is improved on the basis of the first embodiment, the selection of raw materials used medicine and the first Embodiment is identical, except that preparation method.
The preparation method is that the preparation method of the externally used Mongolian medicine of the treatment gout is：The raw material is ground into slightly Coarse powder, is impregnated with by powder with 65~75% ethanol, is reloaded into continuous circumfluence extraction device, 65~75% at a temperature of 60~80 DEG C Alcohol reflux is extracted 2~4 times, merges extract solution, is concentrated, is dried, obtains extract.
Usage and dosage：External application, lavipeditum.Above-mentioned 5-10g of powder is taken, is put in appropriate foot bath water, 40 DEG C of left sides of water temperature are kept The right side, every time immersion is no less than 20 minutes, and soak time is resistant to be limited with patient skin, general up to 1.5 hours, according to disease Feelings weight, can take the circumstances into consideration to be added and subtracted.
It the experiment proved that, the drug effect of the present embodiment is substantially better than the first embodiment, and the dosage of its medicine is greatly reduced 3-7 times, it is easy to packaging to carry, is easy to use.
The third embodiment：Be improved on the basis of the first embodiment, the selection of raw materials used medicine and the first Embodiment is identical, except that preparation method.The preparation method is：The raw material is respectively crushed into coarse powder, it is therein Coarse powder is impregnated with by plantain seed, the Bi roots of grass, cape jasmine with 65~75% ethanol, is reloaded into continuous circumfluence extraction device, at 60~80 DEG C At a temperature of 65~75% alcohol refluxs extract 2~4 times；The red sage root therein, safflower ethyl acetate soak extraction；Said extracted Liquid merges concentration, dried, and obtains extract.
Usage and dosage：External application, lavipeditum.Above-mentioned 5-10g of powder is taken, is put in appropriate foot bath water, 40 DEG C of left sides of water temperature are kept The right side, every time immersion is no less than 20 minutes, and soak time is resistant to be limited with patient skin, general up to 1.5 hours, according to disease Feelings weight, can take the circumstances into consideration to be added and subtracted.
The experiment proved that, because the liposoluble performance of ethyl acetate is better than ethanol, can the grease type among bulk drug into Point more extract, make better than second embodiment of drug effect of the present embodiment, and the dose ratio of its medicine the first implement Example is greatly reduced, and is easy to packaging to carry, also allows for using.
4th kind of embodiment：Be improved on the basis of the first embodiment, the selection of raw materials used medicine and the first Embodiment is identical, except that preparation method.The preparation method is：The raw material is respectively crushed into coarse powder, with 65~ Coarse powder is impregnated with by 75% ethanol, is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs at a temperature of 60~80 DEG C Extract 2~4 times；Filter residue petroleum ether soak extraction；Said extracted liquid is merged concentration, dried, extract is obtained.
Usage and dosage：External application, lavipeditum.Above-mentioned 5-10g of powder is taken, is put in appropriate foot bath water, 40 DEG C of left sides of water temperature are kept The right side, every time immersion is no less than 20 minutes, and soak time is resistant to be limited with patient skin, general up to 1.5 hours, according to disease Feelings weight, can take the circumstances into consideration to be added and subtracted.
It the experiment proved that, because ethanol is strong to water soluble ingredient extractability, petroleum ether is to liposoluble constituent extractability By force, the water solubility and grease-like composition among bulk drug can be more extracted, thus the drug effect of the present embodiment is obvious Better than the third embodiment, and the dose ratio of its medicine the first embodiment is greatly reduced, and is easy to packaging to carry, is easy to use.
5th kind of embodiment：Following bulk drug is taken by weight：3-5 parts of the red sage root, 1-3 parts of safflower, 1-3 parts of plantain seed, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine, 3-5 parts of Echinops latifolius, single 4-6 parts of leaf pseudo-ginseng, 5-7 parts of Androsace umbellata.Its preferred weight part Proportioning is：4 parts of the red sage root, 2 parts of safflower, 2 parts of plantain seed, 4 parts of the Bi roots of grass, 4 parts of cape jasmine, 4 parts of Echinops latifolius, single 5 parts of leaf pseudo-ginseng, point ground 6 parts of plum.Clinical practice single dose weight proportion is preferred：Red sage root 10g, safflower 5g, plantain seed 5g, Bi roots of grass 10g, cape jasmine 10g, Echinops latifolius 10g, single leaf pseudo-ginseng 12g, Androsace umbellata 15g.
Concocting method is：The bulk drug was crushed more than 80 mesh sieve into it is powdered.
Usage and dosage：Outer bath.Above-mentioned powder is taken, is put in appropriate more than 90 DEG C hot water, 40 DEG C or so of water temperature is kept, trouble Portion is generally that brothers are not immersed in the water, and immersion every time is no less than 20 minutes, and soak time is resistant to be limited with patient skin, typically Up to 1.5 hours, according to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.
Bulk drug brief introduction：
Echinops latifolius, Mongolian claim black day Gus scheme-exhale and, Zha Laa-Wu La, black day Gus Tu-Wu La, Wu La-crow Buss, be chrysanthemum The drying cephaloid of section's plant Echinops latifolius.This product bitter, it is cool in nature, dilute, light, soft, blunt.There are heat-clearing, the work(that only shouting pain, synthetism are cured the wound Effect.
Single leaf pseudo-ginseng, Mongolian claims black day Gus Tu-treasured such as, Mo Geqiongdan clouds.For the single leaf pseudo-ginseng of bloodroot Herb is dried, taste micro-sweet, hardship are cool in nature, dry, blunt, soft, dilute.There are heat-clearing, carbuncle processed, detumescence, synthetism, promotion healing.It is conventional In bone fracture, suppuration sexual trauma, arteries and veins wound, cerebral concussion etc..
Androsace umbellata, Mongolian claim Da Lan-Tao Bu its, the wooden soup of Ya Er, be the drying herb of Ofthe Primulaceae Androsace filiformis Refz. It is bitter, sweet, it is cold in nature.Have the effect of heat-clearing, detoxify, subside a swelling, curing the wound, yellow water of dispelling, nourish it is strong, be usually used in it is traumatic suppurate pain Bitterly, pyogenic infections, yellow water be spread in joint bone heat seal and it is conspicuous according to grasserie etc..
Above-mentioned raw materials medicine is traditional osteopathy bone fracture conventional crude drugs, is still belonged to the first time for gout.It is demonstrated experimentally that at the first On the basis of the medicine of embodiment, cooperateed with bone fracture medicine, erosion of the uric acid to joint can be slowed down, delay the course of disease, striven for for treatment Time, it have received unexpected effect.
Experiment Introduction：
Patient 20, is treated with this dipping, and 7 days as one therapeutic course is limited, application method is with two courses for the treatment of：This product is put in bath In water, 38-45 DEG C of water temperature soaks affected part, every time about 20-90 minutes.
Experimental group data using the first embodiment is references.It the results are shown in Table 2.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy gout is substantially better than the curative effect of the first embodiment, and therapeutic effect is notable.
6th kind of embodiment：The raw material of 5th kind of embodiment is respectively crushed into coarse powder, with 65~75% ethanol Coarse powder is impregnated with, is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs are extracted 2~4 times at a temperature of 60~80 DEG C； Filter residue petroleum ether soak extraction；Said extracted liquid is merged concentration, dried, extract is obtained.
Usage and dosage：External application, lavipeditum.Above-mentioned 5-12g of powder is taken, is put in appropriate foot bath water, 40 DEG C of left sides of water temperature are kept The right side, every time immersion is no less than 20 minutes, and soak time is resistant to be limited with patient skin, general up to 1.5 hours, according to disease Feelings weight, can take the circumstances into consideration to be added and subtracted.
It the experiment proved that, better than the 5th kind embodiment of drug effect of the present embodiment, and the 5th kind of implementation of the dose ratio of its medicine Example is greatly reduced, and is easy to packaging to carry, and is easy to use.
7th kind of embodiment：Following bulk drug is taken by weight：3-5 parts of the red sage root, 1-3 parts of safflower, 1-3 parts of plantain seed, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine, 2-4 parts of pseudo-ginseng, 3-5 parts of the bark of eucommia, 3-5 parts of loud, high-pitched sound cloth knot.Its preferred weight part is matched： 4 parts of the red sage root, 2 parts of safflower, 2 parts of plantain seed, 4 parts of the Bi roots of grass, 4 parts of cape jasmine, 3 parts of pseudo-ginseng, 4 parts of the bark of eucommia, 4 parts of loud, high-pitched sound cloth knot.Clinical practice Single dose weight proportion is preferred：Red sage root 10g, safflower 5g, plantain seed 5g, Bi roots of grass 10g, cape jasmine 10g, pseudo-ginseng 7.5g, bark of eucommia 10g, loud, high-pitched sound Cloth knot 10g.
Concocting method is：The bulk drug was crushed more than 80 mesh sieve into it is powdered.
Usage and dosage：Outer bath.Above-mentioned powder is taken, is put in appropriate more than 90 DEG C hot water, 40 DEG C or so of water temperature is kept, trouble Portion is generally that brothers are not immersed in the water, and immersion every time is no less than 20 minutes, and soak time is resistant to be limited with patient skin, typically Up to 1.5 hours, according to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.
Bulk drug brief introduction：
Pseudo-ginseng, Mongolian claim not nur-crow Buss, by paddy it is emerging, receive Mu Baer.For the dry root of panax araliaceae plant.Sweet, Hardship, cool in nature, blunt, light, soft, Grating.Have the effect of it is clearing heat and detoxicating, restrain, stop blooding, curing the wound, subsiding a swelling, relieving pain.Be usually used in fracture the injury of tendon and muscle, Traumatic bleeding, wound suppuration, carbuncle subcutaneous ulcer, fester, scorchingly hot diffusion, sticky early stage of pyogenic infection of skin, carbuncle swells pain etc..
The bark of eucommia, Mongolian claims great thermal map treasured to eat, up to cloth monk, Min Dasonghaili sketch maps-hair all.For the Eucommiaceae plant bark of eucommia Dry bark.Sweet, micro-pungent, it is mild-natured, dry, blunt, again, it is soft, soft.There is heat-clearing synthetism.
Loud, high-pitched sound cloth knot, Mongolian claims tribute bar loud, high-pitched sound cloth knot, such as lattice to admire, west such as Han Xi all-black Buss.For feverfew the western regions of the Yunnan Province phoenix hair Chrysanthemum or the drying herb of Lhasa phoenix hair chrysanthemum.Bitter, warm-natured, removing toxic substances hemostasis of curing the wound.It is usually used in new old wound, arteries and veins to hinder Treatment.
Above-mentioned raw materials medicine is traditional clearing heat and detoxicating conventional crude drugs, is still belonged to the first time for gout.It is demonstrated experimentally that at the first On the basis of the medicine of embodiment, cooperateed with heat-clearing and detoxifying drug, erosion of the uric acid to joint can be slowed down, delay the course of disease, for treatment Race against time, have received unexpected effect.
Experiment Introduction：
Patient 20, is treated with this dipping, and 7 days as one therapeutic course is limited, application method is with two courses for the treatment of：This product is put in bath In water, 38-45 DEG C of water temperature soaks affected part, every time about 20-90 minutes.
Experimental group data using the first embodiment is references.It the results are shown in Table 3.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy gout is substantially better than the curative effect of the first embodiment, and therapeutic effect is notable.
8th kind of embodiment：The raw material of 7th kind of embodiment is respectively crushed into coarse powder, with 65~75% ethanol Coarse powder is impregnated with, is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs are extracted 2~4 times at a temperature of 60~80 DEG C； Filter residue petroleum ether soak extraction；Said extracted liquid is merged concentration, dried, extract is obtained.
Usage and dosage：External application, lavipeditum.Above-mentioned 5-12g of powder is taken, is put in appropriate foot bath water, 40 DEG C of left sides of water temperature are kept The right side, every time immersion is no less than 20 minutes, and soak time is resistant to be limited with patient skin, general up to 1.5 hours, according to disease Feelings weight, can take the circumstances into consideration to be added and subtracted.
It the experiment proved that, better than the 5th kind embodiment of drug effect of the present embodiment, and the 5th kind of implementation of the dose ratio of its medicine Example is greatly reduced, and is easy to packaging to carry, and is easy to use.
9th kind of embodiment：Following bulk drug is taken by weight：3-5 parts of the red sage root, 1-3 parts of safflower, 1-3 parts of plantain seed, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine, 1-3 parts of Echinops latifolius, single 1-3 parts of leaf pseudo-ginseng, 2-4 parts of Androsace umbellata, 1-3 parts of pseudo-ginseng, 1-4 parts of the bark of eucommia, 1-4 parts of loud, high-pitched sound cloth knot.Its preferred weight part is matched：4 parts of the red sage root, 2 parts of safflower, 2 parts of plantain seed, 4 parts of the Bi roots of grass, 4 parts of cape jasmine, 2 parts of Echinops latifolius, single 2 parts of leaf pseudo-ginseng, 3 parts of Androsace umbellata, 2 parts of pseudo-ginseng, 2 parts of the bark of eucommia, 2 parts of loud, high-pitched sound cloth knot.Clinical practice Single dose weight proportion is preferred：Red sage root 10g, safflower 5g, plantain seed 5g, Bi roots of grass 10g, cape jasmine 10g, Echinops latifolius 5g, single leaf pseudo-ginseng 5g, Androsace umbellata 7.5g, pseudo-ginseng 5g, bark of eucommia 5g, loud, high-pitched sound cloth knot 5g.
Concocting method is：The bulk drug was crushed more than 80 mesh sieve into it is powdered.
Usage and dosage：Outer bath.Above-mentioned powder is taken, is put in appropriate more than 90 DEG C hot water, 40 DEG C or so of water temperature is kept, trouble Portion is generally that brothers are not immersed in the water, and immersion every time is no less than 20 minutes, and soak time is resistant to be limited with patient skin, typically Up to 1.5 hours, according to state of an illness weight, it can take the circumstances into consideration to be added and subtracted.
Above-mentioned raw materials medicine is traditional osteopathy bone fracture, clearing heat and detoxicating conventional crude drugs, is still belonged to the first time for gout.Experiment card It is bright, on the basis of the medicine of the first embodiment, cooperateed with the above-mentioned efficacy of a drug, erosion of the uric acid to joint can be slowed down, delay disease Journey, races against time for treatment, receives unexpected effect.
Experiment Introduction：
Patient 20, is treated with this dipping, and 7 days as one therapeutic course is limited, application method is with two courses for the treatment of：This product is put in bath In water, 38-45 DEG C of water temperature soaks affected part, every time about 20-90 minutes.
Experimental group data using the first embodiment is references.It the results are shown in Table 4.
Calculation formula：Cure rate=（Healing number/sum）× 100%, total effective rate=（Sum-invalid number）/ sum × 100%。
It can be seen that, the effect of this drug therapy gout is substantially better than the curative effect of the first embodiment, and therapeutic effect is notable.
Tenth kind of embodiment：The raw material of 9th kind of embodiment is respectively crushed into coarse powder, with 65~75% ethanol Coarse powder is impregnated with, is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs are extracted 2~4 times at a temperature of 60~80 DEG C； Filter residue petroleum ether soak extraction；Said extracted liquid is merged concentration, dried, extract is obtained.
Usage and dosage：External application, lavipeditum.Above-mentioned 8-15g of powder is taken, is put in appropriate foot bath water, 40 DEG C of left sides of water temperature are kept The right side, every time immersion is no less than 20 minutes, and soak time is resistant to be limited with patient skin, general up to 1.5 hours, according to disease Feelings weight, can take the circumstances into consideration to be added and subtracted.
It the experiment proved that, better than the 9th kind embodiment of drug effect of the present embodiment, and the 5th kind of implementation of the dose ratio of its medicine Example is greatly reduced, and is easy to packaging to carry, and is easy to use.

Claims (11)

1. a kind of externally used Mongolian medicine for treating gout, it is characterised in that：The externally used Mongolian medicine of the treatment gout is by following parts by weight Bulk drug be made：3-5 parts of the red sage root, 1-3 parts of safflower, 1-3 parts of plantain seed, 3-5 parts of the Bi roots of grass, 3-5 parts of cape jasmine.
2. a kind of externally used Mongolian medicine for treating gout according to claim 1, it is characterised in that：The parts by weight of the bulk drug Proportioning is：4 parts of the red sage root, 2 parts of safflower, 2 parts of plantain seed, 4 parts of the Bi roots of grass, 4 parts of cape jasmine.
3. a kind of externally used Mongolian medicine for treating gout according to claim 1, it is characterised in that：The weight of the bulk drug is matched somebody with somebody Than being：Red sage root 10g, safflower 5g, plantain seed 5g, Bi roots of grass 10g, cape jasmine 10g.
4. a kind of externally used Mongolian medicine for treating gout according to claim 1, it is characterised in that：The raw material medicaments in part by weight Add 3-5 parts of Echinops latifolius, single 4-6 parts of leaf pseudo-ginseng, 5-7 parts of Androsace umbellata.
5. a kind of externally used Mongolian medicine for treating gout according to claim 1, it is characterised in that：The raw material medicaments in part by weight Add 2-4 parts of pseudo-ginseng, 3-5 parts of the bark of eucommia, 3-5 parts of loud, high-pitched sound cloth knot.
6. a kind of externally used Mongolian medicine for treating gout according to claim 1, it is characterised in that：The raw material medicaments in part by weight Add 1-3 parts of Echinops latifolius, single 1-3 parts of leaf pseudo-ginseng, 2-4 parts of Androsace umbellata, 1-3 parts of pseudo-ginseng, 1-4 parts of the bark of eucommia, Ga Bujie 1-4 parts.
7. a kind of externally used Mongolian medicine for treating gout according to claim 1 or 4 or 5 or 6, it is characterised in that：The treatment The preparation method of the externally used Mongolian medicine of gout is：The bulk drug was crushed and more than 80 mesh sieved, was packaged spare.
8. a kind of externally used Mongolian medicine for treating gout according to claim 1 or 4 or 5 or 6, it is characterised in that：The treatment The preparation method of the externally used Mongolian medicine of gout is：The raw material is ground into coarse powder, coarse powder is impregnated with 65~75% ethanol, then It is fitted into continuous circumfluence extraction device, 65~75% alcohol refluxs are extracted 2~4 times at a temperature of 60~80 DEG C, merges extract solution, it is dense Contract, dry, obtain extract.
9. a kind of externally used Mongolian medicine for treating gout according to claim 1, it is characterised in that：The external application of the treatment gout The preparation method of anaesthetic is：The raw material is respectively crushed into coarse powder, plantain seed therein, the Bi roots of grass, cape jasmine are with 65~75% Coarse powder is impregnated with by ethanol, is reloaded into continuous circumfluence extraction device, at a temperature of 60~80 DEG C 65~75% alcohol refluxs extract 2~ 4 times；Said extracted liquid, is merged concentration, dried, obtain extract by the red sage root therein, safflower ethyl acetate soak extraction.
10. a kind of externally used Mongolian medicine for treating gout according to claim 1 or 4 or 5 or 6, it is characterised in that：The treatment The preparation method of the externally used Mongolian medicine of gout is：The raw material is respectively crushed into coarse powder, coarse powder is soaked with 65~75% ethanol Thoroughly, it is reloaded into continuous circumfluence extraction device, 65~75% alcohol refluxs are extracted 2~4 times at a temperature of 60~80 DEG C；Filter residue stone Oily ether soak extraction；Said extracted liquid is merged concentration, dried, extract is obtained.
11. a kind of externally used Mongolian medicine for treating gout according to claim 1 or 4 or 5 or 6, it is characterised in that：The treatment The application method of the externally used Mongolian medicine of gout is：The medicine is put in bath water, 38-45 DEG C of water temperature, soaks affected part, every time about 20-90 minutes.
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Publication number Priority date Publication date Assignee Title
CN108543024A (en) * 2018-06-21 2018-09-18 陶冬兰 A kind of preparation method of Chinese medicine that treating gout
CN115154509A (en) * 2022-07-21 2022-10-11 内蒙古阿迪斯蒙医药有限公司 Foot bath dredging sustained-release powder and preparation method thereof

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Application publication date: 20170818