CN114269748A - 作为用于治疗癌症的PRC2抑制剂的咪唑并[1,2-c]嘧啶衍生物 - Google Patents

作为用于治疗癌症的PRC2抑制剂的咪唑并[1,2-c]嘧啶衍生物 Download PDF

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Publication number
CN114269748A
CN114269748A CN202080055867.0A CN202080055867A CN114269748A CN 114269748 A CN114269748 A CN 114269748A CN 202080055867 A CN202080055867 A CN 202080055867A CN 114269748 A CN114269748 A CN 114269748A
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China
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compound
methyl
heterocyclyl
equiv
mixture
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CN202080055867.0A
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English (en)
Chinese (zh)
Inventor
M·A·马克斯
J·M·凯查姆
A·C·伯恩斯
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Mirati Therapeutics Inc
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Mirati Therapeutics Inc
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Publication of CN114269748A publication Critical patent/CN114269748A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080055867.0A 2019-06-05 2020-06-03 作为用于治疗癌症的PRC2抑制剂的咪唑并[1,2-c]嘧啶衍生物 Pending CN114269748A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962857515P 2019-06-05 2019-06-05
US62/857,515 2019-06-05
PCT/US2020/035891 WO2020247475A1 (en) 2019-06-05 2020-06-03 Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer

Publications (1)

Publication Number Publication Date
CN114269748A true CN114269748A (zh) 2022-04-01

Family

ID=71842807

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080055867.0A Pending CN114269748A (zh) 2019-06-05 2020-06-03 作为用于治疗癌症的PRC2抑制剂的咪唑并[1,2-c]嘧啶衍生物

Country Status (9)

Country Link
US (2) US12252493B2 (https=)
EP (1) EP3980422A1 (https=)
JP (1) JP7541538B2 (https=)
KR (1) KR20220027933A (https=)
CN (1) CN114269748A (https=)
AU (1) AU2020288563A1 (https=)
CA (1) CA3142711A1 (https=)
IL (1) IL288529A (https=)
WO (1) WO2020247475A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022171166A1 (zh) * 2021-02-10 2022-08-18 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用

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* Cited by examiner, † Cited by third party
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US12252493B2 (en) 2019-06-05 2025-03-18 Mirati Therapeutics, Inc. Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer
WO2023016511A1 (zh) * 2021-08-11 2023-02-16 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022171166A1 (zh) * 2021-02-10 2022-08-18 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用

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JP7541538B2 (ja) 2024-08-28
US12252493B2 (en) 2025-03-18
WO2020247475A1 (en) 2020-12-10
CA3142711A1 (en) 2020-12-10
IL288529A (en) 2022-01-01
US20220274990A1 (en) 2022-09-01
JP2022535577A (ja) 2022-08-09
US20250179082A1 (en) 2025-06-05
AU2020288563A1 (en) 2022-01-06
KR20220027933A (ko) 2022-03-08
EP3980422A1 (en) 2022-04-13

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