AU2020288563A1 - Imidazo(1,2-c)pyrimidine derivatives as PRC2 inhibitors for treating cancer - Google Patents

Imidazo(1,2-c)pyrimidine derivatives as PRC2 inhibitors for treating cancer Download PDF

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Publication number
AU2020288563A1
AU2020288563A1 AU2020288563A AU2020288563A AU2020288563A1 AU 2020288563 A1 AU2020288563 A1 AU 2020288563A1 AU 2020288563 A AU2020288563 A AU 2020288563A AU 2020288563 A AU2020288563 A AU 2020288563A AU 2020288563 A1 AU2020288563 A1 AU 2020288563A1
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Australia
Prior art keywords
compound
methyl
equiv
heterocyclyl
mmol
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Abandoned
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AU2020288563A
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Inventor
Aaron Craig BURNS
John Michael Ketcham
Matthew Arnord MARX
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Mirati Therapeutics Inc
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Mirati Therapeutics Inc
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Publication of AU2020288563A1 publication Critical patent/AU2020288563A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2020288563A 2019-06-05 2020-06-03 Imidazo(1,2-c)pyrimidine derivatives as PRC2 inhibitors for treating cancer Abandoned AU2020288563A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962857515P 2019-06-05 2019-06-05
US62/857,515 2019-06-05
PCT/US2020/035891 WO2020247475A1 (en) 2019-06-05 2020-06-03 Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer

Publications (1)

Publication Number Publication Date
AU2020288563A1 true AU2020288563A1 (en) 2022-01-06

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AU2020288563A Abandoned AU2020288563A1 (en) 2019-06-05 2020-06-03 Imidazo(1,2-c)pyrimidine derivatives as PRC2 inhibitors for treating cancer

Country Status (9)

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US (2) US12252493B2 (https=)
EP (1) EP3980422A1 (https=)
JP (1) JP7541538B2 (https=)
KR (1) KR20220027933A (https=)
CN (1) CN114269748A (https=)
AU (1) AU2020288563A1 (https=)
CA (1) CA3142711A1 (https=)
IL (1) IL288529A (https=)
WO (1) WO2020247475A1 (https=)

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* Cited by examiner, † Cited by third party
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CN114907385A (zh) * 2021-02-10 2022-08-16 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用
WO2023016511A1 (zh) * 2021-08-11 2023-02-16 上海青煜医药科技有限公司 氮杂芳基化合物、其制备方法及应用
WO2023049723A1 (en) * 2021-09-24 2023-03-30 Oric Pharmaceuticals, Inc. Prc2 inhibitors for use in treating blood disorders
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Also Published As

Publication number Publication date
JP7541538B2 (ja) 2024-08-28
US12252493B2 (en) 2025-03-18
WO2020247475A1 (en) 2020-12-10
CA3142711A1 (en) 2020-12-10
IL288529A (en) 2022-01-01
US20220274990A1 (en) 2022-09-01
JP2022535577A (ja) 2022-08-09
US20250179082A1 (en) 2025-06-05
CN114269748A (zh) 2022-04-01
KR20220027933A (ko) 2022-03-08
EP3980422A1 (en) 2022-04-13

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