CN114224979A - Medicine for softening blood vessel and preparation method thereof - Google Patents

Medicine for softening blood vessel and preparation method thereof Download PDF

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Publication number
CN114224979A
CN114224979A CN202111594781.8A CN202111594781A CN114224979A CN 114224979 A CN114224979 A CN 114224979A CN 202111594781 A CN202111594781 A CN 202111594781A CN 114224979 A CN114224979 A CN 114224979A
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parts
blood
radix
medicine
rhizoma
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庞德东
庞道福
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention provides a medicine for softening blood vessels and a preparation method thereof, and relates to the technical field of medicinal preparations. The medicine comprises the following raw materials: radix Codonopsis, rhizoma Atractylodis, ramulus Cinnamomi, Bulbus Fritillariae Cirrhosae, radix Paeoniae alba, rhizoma Gastrodiae, radix scrophulariae, Polyporus, cortex et radix Polygalae, Poria, fructus crataegi, Alismatis rhizoma, Carthami flos, Eucommiae cortex, Saviae Miltiorrhizae radix, Notoginseng radix, rhizoma Ligustici Chuanxiong, radix astragali, retinervus serum, semen Lepidii, pericarpium Arecae, Massa Medicata Fermentata, flos Inulae and endothelium corneum Gigeriae Galli preparata. The medicine of the invention can make blood circulation normal by expanding blood vessels and softening blood clots on the vessel walls, can effectively treat cerebral infarction, blood supply insufficiency of heart and cerebral vessels, hyperlipidemia and other symptoms, and can achieve the purpose of treating both symptoms and root causes, with small side effect and low economic pressure. According to the preparation method disclosed by the invention, different extraction methods are selected for extracting different medicinal materials, so that the utilization rate of the effective components of the medicinal materials can be obviously improved, and the medicinal effect of the medicine is further enhanced.

Description

Medicine for softening blood vessel and preparation method thereof
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a medicament for softening blood vessels and a preparation method thereof.
Background
Arteriosclerosis is closely related to the change of blood fat, which is an important substance in human body and has many very important functions but cannot exceed a certain range. If the blood fat is excessive, the blood is easy to cause 'blood viscosity', the blood is deposited on the blood vessel wall, small plaques are gradually formed, namely 'atherosclerosis', the 'plaques' are increased and enlarged, the blood vessel is gradually blocked, the blood vessel is hardened, the blood flow is slowed, and the blood flow is interrupted when the blood flow is serious. It can even cause complications such as hyperglycemia, hypertension, cerebral infarction, cardiovascular and cerebrovascular diseases, etc.
At present, the angiosclerosis is mainly treated by western medicines, but the western medicines are expensive and have high economic pressure after long-term administration, and the western medicines usually treat the symptoms but not the root causes and have obvious side effects.
Disclosure of Invention
The invention aims to provide a medicine for softening blood vessels, which can ensure normal blood circulation by expanding the blood vessels and softening blood clots on the blood vessel walls, can effectively treat symptoms such as cerebral infarction, insufficient blood supply of heart and cerebral vessels, hyperlipidemia and the like, can achieve the aim of treating both symptoms and root causes, and has small side effect and low economic pressure.
The invention also aims to provide a preparation method of the medicine for softening blood vessels, which is characterized in that different extraction methods are adopted for extracting different medicinal materials, so that the utilization rate of effective components of the medicinal materials can be obviously improved, and the medicine effect of the medicine is further enhanced.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
The invention provides a medicine for softening blood vessels, which comprises the following raw materials in parts by weight: 10-20 parts of codonopsis pilosula, 5-12 parts of rhizoma atractylodis, 5-15 parts of cassia twig, 5-15 parts of bulbus fritilariae, 10-20 parts of radix paeoniae alba, 10-20 parts of rhizoma gastrodiae, 10-20 parts of radix scrophulariae, 11-18 parts of polyporus umbellatus, 5-14 parts of polygala tenuifolia, 25-35 parts of poria cocos, 20-30 parts of hawthorn, 10-20 parts of rhizoma alismatis, 5-15 parts of safflower, 20-30 parts of eucommia ulmoides, 15-30 parts of salvia miltiorrhiza, 10-25 parts of pseudo-ginseng, 10-25 parts of ligusticum wallichii, 25-35 parts of raw astragalus membranaceus, 25-40 parts of blood serum, 10-20 parts of semen lepidii, 10-20 parts of pericarpium arecae, 20-35 parts of medicated leaven, 10-22 parts of inula flower and 10-18 parts of fried endothelium corneum gigeriae galli.
The invention provides a preparation method of a medicine for softening blood vessels, which comprises the following steps:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis, adding ethanol, and extracting for 2-4 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 40-50min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment to obtain an extract C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
The embodiment of the invention at least has the following beneficial effects:
in the invention, the codonopsis pilosula can tonify middle-jiao and Qi, nourish blood and promote the production of body fluid, dilate blood vessels and reduce low-density lipoprotein, triglyceride and cholesterol in serum; rhizoma atractylodis can eliminate dampness, strengthen spleen and dilate blood vessels; the white peony root can calm the liver, nourish blood and astringe yin; rhizoma Gastrodiae has effects of suppressing liver yang; radix scrophulariae has effects in cooling blood, nourishing yin, dilating coronary artery, improving blood rheological property, and increasing cerebral blood flow; eucommia bark can tonify liver and kidney; the raw astragalus can tonify the middle-jiao and Qi, benefit the defense and strengthen the exterior; the rhizoma Ligustici Chuanxiong has effects of promoting blood circulation, activating qi-flowing, dilating cerebral vessels, improving microcirculation, and treating cerebral ischemic injury. The medicinal materials are matched for use, so that the metabolism of the liver, the kidney and the spleen is normal, the blood fat is reduced, and the thrombosis is reduced, so that the cerebral infarction, the hyperlipidemia and the cardiovascular and cerebrovascular diseases are treated, and the medicinal materials supplement each other, so that the immunity of the organism is enhanced while the symptoms of the organism are improved, the resistance of the organism to the diseases is improved, and the treatment effect of the medicament is further improved.
The cassia twig can warm the channels and promote blood circulation, support yang and transform qi, reduce vascular permeability and enhance and regulate blood circulation; the bulbus fritillariae cirrhosae can clear heat, dissipate stagnation and reduce blood pressure; polyporus umbellatus has effects of promoting urination, eliminating dampness, and enhancing immunity; polygala tenuifolia has effects of tranquilizing; the tuckahoe can promote diuresis and eliminate dampness, invigorate the spleen and calm the heart, and reduce blood sugar; the hawthorn can promote qi circulation, remove blood stasis, eliminate turbid pathogen, reduce blood fat, prevent cardiovascular and atherosclerosis, strengthen heart, dilate blood vessel and reduce blood pressure; rhizoma Alismatis has effects in dilating blood vessel, reducing blood lipid, and resisting thrombosis; safflower has the functions of activating blood and stimulating the menstrual flow, protecting acute myocardial ischemia and expanding blood vessels; the red sage root can promote blood circulation, promote menstruation, improve blood circulation and protect myocardial damage; notoginseng radix has selective dilating effect on different part of blood vessel, and can be used for treating myocardial ischemia and cerebral ischemia. The medicinal materials are used in combination, and the blood vessel is softened by regulating blood flow and dilating the blood vessel, so that the conditions of myocardial ischemia and cerebral ischemia are prevented, and the treatment effect of the medicament on cerebral infarction and cardiovascular and cerebrovascular diseases is further improved; meanwhile, the medicine can also reduce blood sugar and blood pressure, and has certain treatment effect on hyperglycemia and hypertension.
The combination of blood serum, semen lepidii, areca peel, charred medicated leaven, inula flower and fried endothelium corneum gigeriae galli can promote qi circulation, relieve epigastric distention, break hardness and eliminate evil, strengthen spleen and stomach, and treat dizziness, chest distress and other conditions by enabling body gas to run, and evacuating middle-jiao qi stagnation; the traditional Chinese medicine composition has the effects of removing blood stasis, softening hard masses, strengthening body resistance and tonifying spleen, treating headache and improving nutrient absorption. The raw materials are reasonable in proportion, the body resistance is strengthened, the foundation is fixed, the nutrition and the defense are harmonized, the purpose of treating both symptoms and root causes can be achieved, almost no side effect is caused, and the economic pressure is low after long-term use.
The preparation method of the invention comprises the steps of pretreating different medicinal materials, mixing the pretreated products, and then sequentially filtering, concentrating and drying. Like this can better draw out the active ingredient of each medicinal material, improve the concentration of active ingredient, and then strengthen the medicine effect, can also improve the medicinal material utilization ratio, avoid the medicinal material extravagant.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The medicine for softening the blood vessel comprises the following raw materials in parts by weight: 10-20 parts of codonopsis pilosula, 5-12 parts of rhizoma atractylodis, 5-15 parts of cassia twig, 5-15 parts of bulbus fritilariae, 10-20 parts of radix paeoniae alba, 10-20 parts of rhizoma gastrodiae, 10-20 parts of radix scrophulariae, 11-18 parts of polyporus umbellatus, 5-14 parts of polygala tenuifolia, 25-35 parts of poria cocos, 20-30 parts of hawthorn, 10-20 parts of rhizoma alismatis, 5-15 parts of safflower, 20-30 parts of eucommia ulmoides, 15-30 parts of salvia miltiorrhiza, 10-25 parts of pseudo-ginseng, 10-25 parts of ligusticum wallichii, 25-35 parts of raw astragalus membranaceus, 25-40 parts of blood serum, 10-20 parts of semen lepidii, 10-20 parts of pericarpium arecae, 20-35 parts of medicated leaven, 10-22 parts of inula flower and 10-18 parts of fried endothelium corneum gigeriae galli.
Codonopsis pilosula, radix Codonopsis, sweet in flavor, neutral in nature, and entering spleen and lung meridians. Radix Codonopsis can reduce serum low density lipoprotein, triglyceride and cholesterol content in hyperlipidemia, improve fibrinolytic enzyme activity, and significantly reduce platelet aggregation rate and plasma thromboxane TXB2 level. The codonopsis pilosula has the effect of resisting hypoxia at normal pressure, can obviously increase the content of glycogen, succinate dehydrogenase and lactate dehydrogenase in myocardium of a mouse, can better improve the diastolic function of the myocardium, dilates peripheral blood vessels, reduces the perfusion resistance of coronary arteries and further improves myocardial ischemia. The codonopsis pilosula extract can obviously increase the number of macrophages in the abdominal cavity of a mouse, enhance the activity of various enzymes, enhance the ability of the macrophages in the abdominal cavity of the mouse to phagocytose chicken red blood cells, and promote the DNA synthesis of mouse spleen lymphocytes activated by the ConA. The crude polysaccharide in the radix codonopsitis can enhance immunity, assist in improving memory, relieve physical fatigue, improve nutritional anemia, assist in protecting gastric mucosa injury, and the saponins can assist in reducing blood fat and have the effects of tonifying middle-jiao and Qi, quenching thirst, invigorating spleen and benefiting lung, nourishing blood and promoting fluid production and the like.
Rhizoma Atractylodis has effects of eliminating dampness, invigorating spleen, and dispelling pathogenic wind and dampness, and can be used for treating damp obstruction of middle warmer, arthralgia due to wind-cold-dampness, swelling and pain of foot and knee, flaccidity, weakness, night blindness, and night blindness. The effective components of rhizoma Atractylodis and adenine nucleotide have competitive inhibition effect on the same mitochondria, thereby inhibiting intracellular oxidative phosphorylation, interfering the transfer process of energy, and further lowering blood sugar. Rhizoma Atractylodis also has effects in dilating blood vessel and regulating blood pressure.
The cassia twig has the effects of sweating, expelling pathogenic factors from muscles, warming channels, promoting blood circulation, supporting yang, regulating qi, dispelling cold and relieving pain. The cassia twig can increase the blood flow of coronary artery, reduce the vascular permeability, increase and regulate the blood circulation, promote the blood to flow to the body surface and improve the effects of sweating and heat dissipation.
Bulbus Fritillariae Cirrhosae, with a bitter taste and a slightly cold nature, enters lung meridian, and has the effects of clearing heat, resolving hard mass, moistening lung, and eliminating phlegm. Bulbus Fritillariae Cirrhosae contains various alkaloids, has effects similar to atropine, and can dilate bronchial smooth muscle, reduce secretion, and contact with smooth muscle spasm. Bulbus Fritillariae Cirrhosae and Sibeimu alkali have blood pressure lowering effect.
White peony root, radix Paeoniae alba, with slightly cold nature, bitter and sour taste, enters liver meridian and spleen meridian, and has effects of suppressing hyperactive liver, relieving pain, nourishing blood, regulating menstruation, astringing yin and arresting sweating. Radix Paeoniae alba and paeoniflorin have effects of dilating blood vessel and increasing blood flow of organs. Paeoniflorin has inhibitory effect on platelet aggregation of rat induced by ADP by in vitro or by intravenous injection, and benzoylpaeoniflorin also has inhibitory effect on platelet aggregation. Paeonia lactiflora pall has strong antibacterial effect and wide antibacterial spectrum. It can also enhance cellular and humoral immunity.
Gastrodia elata with sweet taste and neutral nature enters liver meridian, and has the effects of extinguishing wind and relieving spasm, calming liver yang, dispelling wind and dredging collaterals. Gastrodine and its aglycone, vanillyl alcohol and rhizoma Gastrodiae polysaccharide have tranquilizing effect, the gastrodine has similar structure with inhibitory transmitter gamma-aminobutyric acid in brain, and the gastrodine is converted into gastrodine, combined with benzodiazepine receptor in brain to produce tranquilizing effect, and can also reduce the content of dopamine and norepinephrine in brain. Rhizoma Gastrodiae can also enhance immunity, and its effective component is rhizoma Gastrodiae polysaccharide, which can enhance nonspecific immunity and specific immunity of organism. It also has blood pressure lowering, vertigo resisting, blood platelet aggregation resisting, antithrombotic, antiinflammatory, and analgesic effects.
Radix scrophulariae, being slightly cold in nature, sweet, bitter and salty in flavor, enters lung channel, stomach channel and kidney channel, and has the effects of cooling blood, nourishing yin, purging fire and removing toxicity. The radix scrophulariae has the effects of dilating coronary artery, lowering blood pressure, resisting platelet aggregation, promoting fibrinolysis, improving blood rheological property and resisting cerebral ischemia injury, and can significantly reduce cerebral infarction volume of rats 24h after ischemia, significantly improve nerve function and increase cerebral blood flow.
Polyporus umbellatus has mild property, sweet and bland taste, and has effects of promoting urination and eliminating dampness. Polyporus polysaccharide is the main effective component of Polyporus with immunity enhancing effect, and can improve phagocytic ability of abdominal cavity macrophage of tumor-bearing mice and chemotherapy mice, directly promote mouse cell mitosis, obviously promote proliferation reaction of mouse T cell to COPA and B cell to bacterial lipopolysaccharide, enhance delayed type hypersensitivity induced by mouse heterotypic splenocyte, and obviously enhance killing activity of mouse heterotypic splenocyte activated cytotoxic T Cell (CTL) to target cell.
Polygala tenuifolia has warm nature, bitter and pungent taste, enters heart channel, kidney channel and lung channel, and has the effects of soothing nerves, promoting intelligence, eliminating phlegm and relieving swelling. Polygala tenuifolia contains saponin, and has erythrocyte dissolving effect.
Poria cocos, sweet and light in flavor, neutral in nature, enters heart, lung, spleen and kidney channels, and has the effects of promoting diuresis, eliminating dampness, invigorating spleen and calming heart. Pachyman has effects of resisting thymus atrophy, resisting spleen enlargement and inhibiting tumor growth, enhancing phagocytic function of mouse macrophage, increasing ANAE positive lymphocyte number, increasing mouse spleen antibody secretion cell number, and accelerating leukocyte reduction and recovery of white mouse caused by cyclophosphamide. In addition, the carboxymethyl pachyman also has the functions of immunoregulation, protecting liver and lowering transaminase, indirect antivirus, and the like. It also has tranquilizing and blood sugar lowering effects.
The hawthorn is sour and sweet, is slightly warm, enters spleen, stomach and liver channels, and has the effects of promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbid pathogen and reducing blood fat. The hawthorn can prevent cardiovascular diseases, reduce serum cholesterol and triglyceride and effectively prevent and treat atherosclerosis; increasing myocardial contraction force, increasing cardiac output, and strengthening heart and preventing angina pectoris. The total flavone in fructus crataegi has effects of dilating blood vessel and lowering blood pressure.
Rhizoma alismatis is sweet and light in taste and cold in nature, enters kidney and bladder channels, and has the effects of promoting diuresis and excreting dampness, clearing heat, dissolving turbidity and reducing blood fat. Rhizoma alismatis can obviously reduce total cholesterol and triglyceride of obese mice, increase the concentration of high-density lipoprotein-cholesterol, and has obvious effects of reducing blood sugar and blood fat, and protecting islet tissues from being damaged. And secondly, the alisma orientale also has the effects of resisting platelet aggregation, resisting thrombosis and enhancing the activity of fibrinolytic enzyme, and can inhibit or relieve the occurrence of atherosclerosis in various aspects such as reducing blood fat, inhibiting endothelial cell injury, resisting thrombosis and the like. Alisma orientale may act to dilate blood vessels by vascular endothelial cells increasing the release of prostacyclin (PGI2) and carbon monoxide (CO). The active components of Alismatis rhizoma have effects of enhancing reticuloendothelial system activity and anticomplementary activity, inhibiting lipopolysaccharide activation and macrophage generation of NO, and resisting allergy.
Safflower, warm in nature, pungent in flavor, enters heart and liver meridians, and has the effects of activating blood circulation to promote menstruation, dissipating blood stasis and relieving pain. The safflower can obviously protect the acute myocardial ischemia of rats or rabbits caused by the pituitrin; the method can obviously reduce the degree of acute myocardial ischemia of the anesthetized dog caused by repeated and transient blockage of coronary artery blood flow, reduce the range and slow the heart rate, protect the edge of an acute myocardial infarction area, narrow the infarction range and reduce the elevation amplitude of the electrocardiogram ST section at the edge area, thereby improving the supply and demand relationship of ischemic myocardial oxygen. Safflower can make the hind limb and rabbit ear of guinea pig with increased tension show vasodilatation, and has obvious effect with increasing dosage, and also can increase arterial blood flow.
Eucommia bark, cortex Eucommiae, sweet and slightly pungent, warm in nature, enters liver and kidney meridians, and has effects of nourishing liver and kidney, strengthening tendons and bones, and preventing miscarriage. The eucommia bark can reduce the blood pressure of a patient with hypertension and improve symptoms such as dizziness, insomnia and the like; can enhance the activity of mouse erythrocyte SOD and the weight of adrenal gland; also has blood pressure lowering and diuretic effects.
Salvia miltiorrhiza, which is slightly cold in nature and bitter in taste, enters heart and liver meridians, and has the effects of removing blood stasis, relieving pain, promoting blood circulation, treating dysmenorrhea, clearing heart fire and relieving restlessness. The red sage root can increase coronary flow, reduce myocardial excitability and conductivity, and has obvious protective effect on myocardial damage caused by acute myocardial ischemia and hypoxia. The anti-myocardial ischemia mechanism is: by protecting the disc damage of the myocardial cells and maintaining the integrity of cell membranes, the damage to capillaries at the edge of an ischemic area is light, the establishment of collateral circulation is facilitated, and the blood supply is increased, so that the repair of damaged tissues and the regeneration of the myocardial cells are accelerated. The Saviae Miltiorrhizae radix has effects in improving microcirculation, resisting blood platelet aggregation and thrombosis, reducing blood viscosity, and improving blood circulation.
Notoginseng radix, warm in nature, sweet and slightly bitter in taste, enters liver and stomach meridians, and has effects of removing blood stasis, stopping bleeding, and relieving swelling and pain. Notoginsenoside and panaxatriol glycoside can resist platelet aggregation and thrombin, and promote fibrinolysis, so as to achieve antithrombotic effect; the mechanism of anti-platelet aggregation is to increase the cAMP content in platelets, reduce the synthesis of thromboxane A2 and inhibit Ca2+5-HT, etc. Notoginseng radix total saponin for treating different part of blood vesselHas selective dilating effect, and can be used for reducing diastolic pressure, resisting myocardial ischemia, resisting cerebral ischemia, resisting arrhythmia, resisting atherosclerosis, etc.
Rhizoma Ligustici Chuanxiong has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Ligustrazine and ferulic acid are important effective components of rhizoma Ligustici Chuanxiong. Ligustrazine can rapidly penetrate blood brain barrier, dilate cerebral vessels, improve microcirculation, and increase cerebral blood flow of anesthetized dog. Ligustrazine can improve fluidity of ischemic brain mitochondrial membrane and treat cerebral cell membrane Ca2+–Mg2+The ATP enzyme activity is protective and can reduce intracellular Ca2+The overload of the brain has therapeutic effect on cerebral ischemic injury. Ligustrazine can be used for resisting myocardial ischemia by dilating coronary artery; it also has effects in dilating blood vessel, lowering blood pressure, tonifying heart, tranquilizing mind, and relieving pain.
Radix rehmanniae stilbene has effects of invigorating spleen and replenishing qi, arresting sweating, benefiting wei and consolidating superficial resistance, inducing diuresis for removing edema, removing toxic substance and promoting granulation. The body surface can be ensured to smoothly run by reinforcing and strengthening the defensive qi of the body surface, namely, the body surface can play a role in protecting the yang qi and can prevent pathogenic factors such as wind, cold, dampness, summer heat and the like from invading the body.
It has the actions of cooling blood, stopping bleeding, clearing away heat and toxic material.
Ting Li Zi is pungent, bitter and cold in flavor, enters lung and bladder channels, and has the effects of breaking hardness and expelling pathogenic factors, purging lung and promoting diuresis, eliminating phlegm and relieving asthma. Semen Lepidii can inhibit capillary permeability and inflammatory exudation, reduce inflammatory exudation of serosal, synovial membrane and alveolar parietal blood vessels, and reabsorb the exudation solution. Semen Lepidii contains cardiac glycoside, and has effects in increasing output of heart, and reducing venous pressure. Semen Lepidii also has antibacterial and diuretic effects.
The areca peel, slightly warm in nature and pungent in flavor, enters spleen channel, stomach channel, large intestine channel and small intestine channel, and has the effects of promoting qi circulation, relieving epigastric distention, and inducing diuresis to alleviate edema. The product contains arecoline, arecaidine and alpha-catechin. The product has effects in exciting gastrointestinal smooth muscle, promoting gastrointestinal motility, and promoting fibrinolysis. The areca peel can stimulate parasympathetic nerve, promote gastrointestinal peristalsis to cause diarrhea, slow heart beat, reduce blood pressure and promote salivary gland and sweat secretion.
The charred medicated leaven is sweet, pungent and warm, enters spleen and stomach channels, and has the effects of promoting digestion, relieving stasis, strengthening spleen and stomach. The medicated leaven contains vitamin B complex, enzymes, ergosterol, protein, etc., so that it has vitamin B-like effect and can promote the digestion, absorption and utilization of protein in food. It can also be used for treating spleen and stomach deficiency, chest distress, bitter taste, and tastelessness.
Inula flower, flos Inulae, bitter, pungent and salty in flavor and warm in nature, has the main functions of descending qi, resolving phlegm and moving water, and is commonly used for the symptoms of vomiting due to warm-air, cough, asthma and excessive phlegm, etc. Flos Inulae mainly contains quercetin, isoquercetin, caffeic acid, chlorogenic acid, inulin and taraxasterol.
The fried gizzard-membrane refers to the fried chicken's gizzard-membrane which is sweet and neutral in nature and enters spleen channel, stomach channel, small intestine channel and bladder channel, and can promote digestion, invigorate spleen, arrest seminal emission, relieve stranguria and dissipate stone. Modern pharmacological studies show that the endothelium corneum gigeriae galli has the effects of regulating gastrointestinal functions, resisting atherosclerosis, reducing blood fat and blood sugar and the like.
The codonopsis pilosula, the rhizoma atractylodis, the white paeony root, the gastrodia elata, the radix scrophulariae, the eucommia ulmoides and the raw astragalus membranaceus are matched for use, so that the metabolism of the liver, the kidney and the spleen is normal, the blood fat is reduced, and the thrombosis is reduced, so that the cerebral infarction, the hyperlipidemia and the cardiovascular and cerebrovascular diseases are treated, and the codonopsis pilosula, the rhizoma atractylodis, the white paeony root, the gastrodia elata, the radix scrophulariae, the eucommia ulmoides and the raw astragalus membranaceus supplement each other, so that the immunity of an organism is enhanced while the symptoms of the organism are improved, the resistance of the organism to the diseases is improved, and the drug treatment effect is further improved. The cassia twig, the bulbus fritilariae, the grifola, the polygala tenuifolia, the poria cocos, the hawthorn, the rhizoma alismatis, the safflower, the salvia miltiorrhiza and the pseudo-ginseng are used in a matching way, and the blood vessels are softened by regulating the blood flow and expanding the blood vessels, so that the myocardial ischemia and cerebral ischemia conditions are prevented, and the treatment effect of the medicine on cerebral infarction and cardiovascular and cerebrovascular diseases is further improved; meanwhile, the medicine can also reduce blood sugar and blood pressure, and has certain treatment effect on hyperglycemia and hypertension. The combination of blood serum, semen lepidii, areca peel, charred medicated leaven, inula flower and fried endothelium corneum gigeriae galli can promote qi circulation, relieve epigastric distention, break hardness and eliminate evil, strengthen spleen and stomach, and treat dizziness, chest distress and other conditions by enabling body gas to run, and evacuating middle-jiao qi stagnation; the traditional Chinese medicine composition has the effects of removing blood stasis, softening hard masses, strengthening body resistance and tonifying spleen, treating headache and improving nutrient absorption. The raw materials are reasonable in proportion, the functions of strengthening body resistance and consolidating constitution and harmonizing ying and weiqi can achieve the purpose of treating both symptoms and root causes, almost has no side effect, and is low in economic pressure after long-term use.
A preparation method of a medicine for softening blood vessels comprises the following steps:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis with cellulase at 50-60 deg.C and pH of 4-5 for 1-2 hr, adding ethanol, and extracting for 2-4 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 40-50min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment to obtain an extract C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
The codonopsis pilosula, the bulbus fritilariae and the areca peel are subjected to enzymolysis by adopting cellulase, so that cell walls of medicinal materials can be damaged, medicinal effective components of the medicinal materials are easier to dissolve out, and the extraction rate of the effective components is improved. Performing enzymolysis at 50-60 deg.C and pH of 4-5 for 1-2 hr. Under the condition, the cellulase has the best enzymolysis effect on cell walls and the fastest enzymolysis speed, so that the effective component precipitation effect is the best, meanwhile, the activity of the cellulase can be prevented from being damaged, and the enzymolysis effect is further improved. Adding ethanol, and extracting for 2-4 hr. The method has the advantages that the ethanol extraction is carried out after enzymolysis, so that the effective components in the medicinal materials can be extracted, and compared with a single ethanol extraction method, the yield of the effective components in the medicinal materials is improved by about 30%.
Extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water, wherein the effective components are polysaccharides which are water soluble components, the water extraction method is more favorable for dissolving polysaccharide components, and the extraction effect of polysaccharide components is the best when extracting for 40-50 min. Decocting blood serum and water, concentrating the decoction, centrifuging, collecting supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment. The active carbon is adopted for processing, so that colored impurities in the serum can be removed, the effective components in the serum can be well reserved, and the purity of the effective components can be improved. Adding mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction.
Decocting the blood serum with water for 3 times (each time for 20-30 min), and mixing the decoctions for 3 times. The effective components in the serum can be conveniently extracted to the maximum extent through multiple times of decoction, and the extraction method is simple, quick and convenient to operate. Decocting for 3 times, specifically decocting the residue with water, and extracting the residue.
Before extracting with water, the mixture of rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata preparata is further pulverized into 150 mesh fine powder with particle size of 100 meshes, and soaking the fine powder with warm water for 20-30 min. Through crushing and soaking, the effective components in the fine powder are more beneficial to dissolution, and the extraction rate of the effective components can be improved during subsequent water extraction, so that the drug effect of the drug is enhanced.
The volume ratio of the ethanol to the trichloromethane is 1 (3-4). Under the mixture ratio, the mixed solvent has the best extraction effect on the effective components in the rest raw materials.
Filtering, concentrating, and drying sequentially, filtering with 200-mesh 250-mesh gauze, vacuum concentrating for 15-20min, and spray drying for 30-40 min. Under the conditions, the obtained medicinal powder particles are more convenient for the body to absorb and can play the drug effect more quickly, the water content of the medicinal powder is most suitable, the medicinal powder is convenient to store, and the deterioration is avoided.
Also comprises adding excipient into the medicinal powder to make into capsule, wherein the excipient is one or more of microcrystalline cellulose, micropowder silica gel and dextrin. The capsule is convenient to carry and take, and improves the comfort level when taking the medicine.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A medicine for softening blood vessels comprises the following raw materials: 10g of codonopsis pilosula, 5g of rhizoma atractylodis, 5g of cassia twig, 5g of bulbus fritillariae cirrhosae, 10g of radix paeoniae alba, 10g of rhizoma gastrodiae, 10g of radix scrophulariae, 11g of polyporus umbellatus, 5g of polygala tenuifolia, 25g of poria cocos, 20g of hawthorn, 10g of rhizoma alismatis, 5g of safflower carthamus, 20g of eucommia ulmoides, 15g of salvia miltiorrhiza, 10g of pseudo-ginseng, 10g of ligusticum wallichii, 25g of raw astragalus membranaceus, 25g of blood serum, 10g of semen lepidii, 10g of pericarpium arecae, 20g of charred medicated leaven, 10g of inula flower and 10g of fried endothelium corneum gigeriae galli.
A preparation method of a medicine for softening blood vessels comprises the following steps:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis, adding ethanol, and extracting for 2 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 40min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment to obtain an extract C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
In this example, the volume ratio of ethanol to chloroform was 1:3.
Example 2
A medicine for softening blood vessels comprises the following raw materials: 20g of codonopsis pilosula, 12g of rhizoma atractylodis, 15g of cassia twig, 15g of bulbus fritillariae cirrhosae, 20g of radix paeoniae alba, 20g of rhizoma gastrodiae, 20g of radix scrophulariae, 18g of polyporus umbellatus, 14g of polygala tenuifolia, 35g of poria cocos, 30g of hawthorn, 20g of rhizoma alismatis, 15g of safflower carthamus, 30g of eucommia ulmoides, 30g of salvia miltiorrhiza, 25g of pseudo-ginseng, 25g of ligusticum wallichii, 35g of raw astragalus membranaceus, 40g of blood serum, 20g of semen lepidii, 20g of pericarpium arecae, 35g of medicated leaven, 22g of inula flower and 18g of fried endothelium corneum gigeriae galli.
A preparation method of a medicine for softening blood vessels comprises the following steps:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis, adding ethanol, and extracting for 4 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 50min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment to obtain an extract C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
In this example, the volume ratio of ethanol to chloroform was 1: 4.
Example 3
A medicine for softening blood vessels comprises the following raw materials: 12g of codonopsis pilosula, 10g of rhizoma atractylodis, 8g of cassia twig, 12g of bulbus fritillariae cirrhosae, 12g of radix paeoniae alba, 18g of rhizoma gastrodiae, 11g of radix scrophulariae, 14g of polyporus umbellatus, 10g of polygala tenuifolia, 27g of poria cocos, 22g of hawthorn, 16g of rhizoma alismatis, 12g of safflower carthamus, 21g of eucommia ulmoides, 25g of salvia miltiorrhiza, 13g of pseudo-ginseng, 13g of ligusticum wallichii, 28g of raw astragalus membranaceus, 35g of blood serum, 14g of semen lepidii, 12g of pericarpium arecae, 23g of medicated leaven, 14g of inula flower and 13g of fried endothelium corneum gigeriae galli.
A preparation method of a medicine for softening blood vessels comprises the following steps:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis, adding ethanol, and extracting for 3 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 45min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment to obtain an extract C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
In this example, the volume ratio of ethanol to chloroform was 1: 3.5.
Example 4
A medicine for softening blood vessels comprises the following raw materials: 15g of codonopsis pilosula, 8g of rhizoma atractylodis, 10g of cassia twig, 8g of bulbus fritillariae cirrhosae, 15g of radix paeoniae alba, 15g of rhizoma gastrodiae, 15g of radix scrophulariae, 15g of polyporus umbellatus, 8g of polygala tenuifolia, 30g of poria cocos, 25g of hawthorn, 15g of rhizoma alismatis, 10g of safflower carthamus, 25g of eucommia ulmoides, 20g of salvia miltiorrhiza, 15g of pseudo-ginseng, 15g of ligusticum wallichii, 30g of raw astragalus membranaceus, 30g of blood serum, 15g of semen lepidii, 15g of pericarpium arecae, 30g of medicated leaven, 15g of inula flower and 15g of fried endothelium corneum gigeriae galli.
A preparation method of a medicine for softening blood vessels comprises the following steps:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis, adding ethanol, and extracting for 2.5 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 42min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially subjecting the supernatant to activated carbon and autoclaving treatment to obtain an extract C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
In this example, the volume ratio of ethanol to chloroform was 1: 3.8.
Example 5
The raw materials in this example are the same as those in example 4, except that the operation conditions are defined, specifically:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis with cellulase at 60 deg.C and pH of 5 for 2 hr. The remaining procedure was the same as in example 4.
Example 6
The raw materials in this example were the same as in example 4, except that: decocting the blood serum with water for 3 times (30 min each time), and mixing the decoctions for 3 times. The remaining procedure was the same as in example 4.
Example 7
The raw materials in this example were the same as in example 4, except that: extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water, pulverizing into 150 mesh fine powder, and soaking in warm water for 30 min. The remaining procedure was the same as in example 4.
Example 8
The raw materials in this example were the same as in example 4, except that: filtering, concentrating, drying, filtering with 250 mesh gauze, vacuum concentrating for 20min, spray drying for 40min to obtain medicinal powder, adding excipient, and making into capsule. The remaining procedure was the same as in example 4.
Example 9
The raw materials in this example were the same as in example 4, except that: mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis with cellulase at 55 deg.C and pH of 4.5 for h. Decocting the blood serum with water for 3 times (each for 20 min), and mixing the decoctions for 3 times. Extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water, pulverizing into 150 mesh fine powder, and soaking in warm water for 30 min. Filtering, concentrating, drying, filtering with 200 mesh gauze, vacuum concentrating for 15min, spray drying for 30min to obtain medicinal powder, adding excipient, and making into capsule. The remaining procedure was the same as in example 4.
Test results
1. Toxicological test
Acute toxicity: 9 rats were selected, and the drug of example 1 was administered to 9 mice individually at 12g/kg by gavage (or suspension, equivalent to 120-fold the clinical amount) and observed for 7 days. The results show that: the rats all had normal activities, normal range of hair color and food intake, and abnormal changes of respiration and blood pressure.
Long-term toxicity test: 9 guinea pigs and 4 rabbits were selected and gavaged with the drug of example 1 at 6g/kg for 20 days, and the trachea, heart, liver, lung, kidney, brain, esophagus, stomach and intestine, pancreas and adrenal gland were examined by conventional pathological section examination, and no abnormal change was observed in each organ.
The result shows that the medicine of the embodiment of the invention has no toxic or side effect.
2. Clinical trial
90 subjects were selected, with an age of 45-55 years, with an average age of 50.5 years. The clinical manifestations are cerebral artery blood supply insufficiency and primary hypertension; cerebral deep part white matter ischemia focus, limbs blood vessel ultrasonic prompt left lower limb far end artery blood perfusion insufficient, peripheral artery rigidity increase; the cervical overtopping prompts thickening of the double-bulbar intima with plaque formation; bilateral anterior cerebral artery flow asymmetry. The subjects were randomly divided into 9 groups, and 1-9 groups were sequentially administered the drugs of examples 1-9 three times a day, 10mg each time, for 2 months, and then three times a day, 5mg each time, for 4 months. After 6 months, the subjects were tested for the following data, which are the average of each group:
TABLE 1 examination results
Figure BDA0003430205160000161
Figure BDA0003430205160000171
As can be seen from Table 1, the drugs of examples 1 to 9 of the present invention can reduce the platelet aggregation rate, the whole blood viscosity and the ET content in plasma. Therefore, the medicine of the invention can soften blood vessels and ensure normal blood circulation of the body. And the test results of the testers are investigated, which shows that the blood pressure and the blood fat of the testers are obviously reduced, the phenomena of headache and dizziness rarely occur, and the diseases almost have no relapse.
In conclusion, the medicine for softening blood vessels disclosed by the embodiment of the invention can be used for expanding blood vessels and softening blood clots on the blood vessel walls to ensure normal blood circulation, can be used for effectively treating cerebral infarction, insufficient blood supply of heart and cerebral vessels, hyperlipidemia and other symptoms and root causes, and is small in side effect and low in economic pressure. According to the preparation method of the medicine for softening the blood vessel, different extraction methods are selected for extracting different medicinal materials, so that the utilization rate of effective components of the medicinal materials can be remarkably improved, and the medicine effect of the medicine is further enhanced.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The medicine for softening blood vessels is characterized by comprising the following raw materials in parts by weight: 10-20 parts of codonopsis pilosula, 5-12 parts of rhizoma atractylodis, 5-15 parts of cassia twig, 5-15 parts of bulbus fritilariae, 10-20 parts of radix paeoniae alba, 10-20 parts of rhizoma gastrodiae, 10-20 parts of radix scrophulariae, 11-18 parts of polyporus umbellatus, 5-14 parts of polygala tenuifolia, 25-35 parts of poria cocos, 20-30 parts of hawthorn, 10-20 parts of rhizoma alismatis, 5-15 parts of safflower, 20-30 parts of eucommia ulmoides, 15-30 parts of salvia miltiorrhiza, 10-25 parts of pseudo-ginseng, 10-25 parts of ligusticum wallichii, 25-35 parts of raw astragalus membranaceus, 25-40 parts of blood serum, 10-20 parts of semen lepidii, 10-20 parts of pericarpium arecae, 20-35 parts of medicated leaven, 10-22 parts of inula flower and 10-18 parts of fried endothelium corneum gigeriae galli.
2. A method for preparing a medicament for vaso-softening according to claim 1, comprising the steps of:
mixing radix Codonopsis, Bulbus Fritillariae Cirrhosae and pericarpium Arecae, performing enzymolysis, adding ethanol, and extracting for 2-4 hr to obtain extractive solution A; extracting rhizoma Gastrodiae, Polyporus, Poria and Massa Medicata Fermentata with water for 40-50min to obtain extractive solution B; mixing and decocting the blood serum and water, concentrating and centrifuging the decoction, taking supernatant, and sequentially performing activated carbon and autoclaving treatment on the supernatant to obtain an extracting solution C; adding a mixed solvent of ethanol and chloroform into the rest raw materials for reflux extraction to obtain an extracting solution D; mixing the above extractive solutions A, B, C, D, filtering, concentrating, and drying to obtain medicinal powder.
3. The preparation method according to claim 2, wherein the enzymolysis is carried out with cellulase at 50-60 ℃ for 1-2 h.
4. The method of claim 3, wherein the enzymatic hydrolysis further comprises adjusting the pH to 4-5.
5. The preparation method according to claim 2, wherein the serum is decocted in water for 3 times, each time for 20-30min, and the 3 decoctions are combined.
6. The method as claimed in claim 2, wherein the step of extracting the mixture of gastrodia elata, polyporus umbellatus, poria cocos and burnt medicated leaven with water comprises the steps of pulverizing the mixture into fine powder with a particle size of 100 meshes and 150 meshes, and soaking the fine powder in warm water for 20-30 min.
7. The method according to claim 2, wherein the volume ratio of ethanol to chloroform is 1 (3-4).
8. The method as claimed in claim 2, wherein the filtering, concentrating and drying are performed sequentially by filtering with 200-mesh gauze of 250 meshes, vacuum concentrating for 15-20min and spray drying for 30-40 min.
9. The method of claim 2, further comprising adding an excipient to the powder to prepare a capsule.
10. The method of claim 9, wherein the excipient is one or more of microcrystalline cellulose, micro silica gel, and dextrin.
CN202111594781.8A 2021-12-23 2021-12-23 Medicine for softening blood vessel and preparation method thereof Pending CN114224979A (en)

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Citations (2)

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Publication number Priority date Publication date Assignee Title
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Publication number Priority date Publication date Assignee Title
CN1539439A (en) * 2003-04-22 2004-10-27 黄益新 Medicine for intenerating blood vessel
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Title
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