CN114173771A - 用于治疗眼部蛋白质聚集疾病的药理学试剂 - Google Patents

用于治疗眼部蛋白质聚集疾病的药理学试剂 Download PDF

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Publication number
CN114173771A
CN114173771A CN202080054595.2A CN202080054595A CN114173771A CN 114173771 A CN114173771 A CN 114173771A CN 202080054595 A CN202080054595 A CN 202080054595A CN 114173771 A CN114173771 A CN 114173771A
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CN
China
Prior art keywords
alkyl
radical
group
hydrogen
acid
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CN202080054595.2A
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English (en)
Chinese (zh)
Inventor
斯里达尔·戈文达·普拉萨德
马歇尔·克拉克·彼得曼
桑托什·辛哈
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Praxair Pharmaceutical Co
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Praxair Pharmaceutical Co
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Publication of CN114173771A publication Critical patent/CN114173771A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080054595.2A 2019-05-31 2020-06-01 用于治疗眼部蛋白质聚集疾病的药理学试剂 Pending CN114173771A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962855560P 2019-05-31 2019-05-31
US62/855,560 2019-05-31
PCT/US2020/035592 WO2020243720A1 (en) 2019-05-31 2020-06-01 Pharmacological agents for treating protein aggregation diseases of the eye

Publications (1)

Publication Number Publication Date
CN114173771A true CN114173771A (zh) 2022-03-11

Family

ID=73553335

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080054595.2A Pending CN114173771A (zh) 2019-05-31 2020-06-01 用于治疗眼部蛋白质聚集疾病的药理学试剂

Country Status (8)

Country Link
US (1) US20220241247A1 (https=)
EP (1) EP3976017A4 (https=)
JP (1) JP2022534420A (https=)
CN (1) CN114173771A (https=)
BR (1) BR112021024151A2 (https=)
CA (1) CA3141998A1 (https=)
MX (1) MX2021014682A (https=)
WO (1) WO2020243720A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115298168A (zh) * 2020-01-28 2022-11-04 普罗泰格生物制药公司 用于稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错误折叠的化合物、组合物和方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250019352A1 (en) * 2021-06-29 2025-01-16 Plex Pharmaceuticals, Inc. Pharmacological agents for treating ophthalmic diseases
WO2023009585A2 (en) * 2021-07-28 2023-02-02 Protego Biopharma, Inc. Transthyretin stabilizing compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101198598A (zh) * 2004-05-20 2008-06-11 弗尔德里克斯制药股份有限公司 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法
WO2011116123A1 (en) * 2010-03-19 2011-09-22 Irm Llc Tafamidis for the treatment of ophthalmic diseases
CN103889407A (zh) * 2011-10-24 2014-06-25 索姆创新生物技术公司 用于甲状腺素运载蛋白相关的淀粉样变性的新疗法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2586330C2 (ru) * 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
US9499527B2 (en) * 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
US9169214B2 (en) * 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
US9790269B2 (en) * 2013-02-08 2017-10-17 Misfolding Diagnostics, Inc. Transthyretin antibodies and uses thereof
RU2015138891A (ru) * 2013-03-08 2017-04-11 Аллерган, Инк. Конъюгаты антибиотиков, напрямую связанные со стероидными препаратами
PE20151747A1 (es) * 2013-03-14 2015-12-18 Univ Massachusetts Metodo para inhibir cataratas y presbicia
US11872236B2 (en) * 2018-04-05 2024-01-16 Calasia Pharmaceuticals, Inc. Pharmacological agents for treating ocular diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101198598A (zh) * 2004-05-20 2008-06-11 弗尔德里克斯制药股份有限公司 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法
WO2011116123A1 (en) * 2010-03-19 2011-09-22 Irm Llc Tafamidis for the treatment of ophthalmic diseases
CN103889407A (zh) * 2011-10-24 2014-06-25 索姆创新生物技术公司 用于甲状腺素运载蛋白相关的淀粉样变性的新疗法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
1222800-98-7，STN结构检索, pages 1, Retrieved from the Internet <URL:registry> *
A. C. MARTINS等: "Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review", BIOMED RESEARCH INTERNATIONAL, pages 1 - 10 *
ARIEL M. ALPERSTEIN等: "Amyloid found in human cataracts with twodimensional infrared spectroscopy", PNAS LATEST ARTICLES, pages 1 - 6 *
LEAH N. MAKLEY等: "Pharmacological chaperone for a-crystallin partially restores transparency in cataract models", SCIENCEMAG.ORG, vol. 350, pages 674 - 677 *
MELO BEIRÃO等: "Anticipation of presbyopia in Portuguese familial amyloidosis ATTR V30M", AMYLOID, vol. 18, no. 3, pages 92 - 97, XP009532005, DOI: 10.3109/13506129.2011.576719 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115298168A (zh) * 2020-01-28 2022-11-04 普罗泰格生物制药公司 用于稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错误折叠的化合物、组合物和方法

Also Published As

Publication number Publication date
JP2022534420A (ja) 2022-07-29
US20220241247A1 (en) 2022-08-04
CA3141998A1 (en) 2020-12-03
BR112021024151A2 (pt) 2022-02-08
MX2021014682A (es) 2022-04-06
WO2020243720A9 (en) 2021-02-04
WO2020243720A1 (en) 2020-12-03
EP3976017A4 (en) 2023-06-14
EP3976017A1 (en) 2022-04-06

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