CN114167071A - Multifunctional sample analysis system - Google Patents
Multifunctional sample analysis system Download PDFInfo
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- CN114167071A CN114167071A CN202210124834.8A CN202210124834A CN114167071A CN 114167071 A CN114167071 A CN 114167071A CN 202210124834 A CN202210124834 A CN 202210124834A CN 114167071 A CN114167071 A CN 114167071A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00108—Test strips, e.g. paper
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Abstract
The invention provides a multifunctional sample analysis device, which comprises a sample storage device for storing a sample reagent, a reaction reagent storage device for storing a reaction reagent required by reaction, a luminescence and photometry reading chemiluminescence detection device for detecting the sample reagent, a biochemical detection device for detecting the biochemical and photometry reading of the sample reagent, a fluorescence detection device for detecting the fluorescence and photometry reading of the sample reagent and a sample adding device, wherein the sample adding device is used for adding the sample in the sample storage device and the reaction reagent in the reaction reagent storage device into the chemiluminescence detection device, the biochemical detection device and the fluorescence detection device. This scheme is through above-mentioned setting, can be integrated to an organic whole with a plurality of testing platform, reduces the holistic occupation space of equipment, and the maintenance and the operation of instrument are all more convenient, can reduce the staff simultaneously and shift the time of sample at each instrument, improve work efficiency and reduce the error that the error produced.
Description
Technical Field
The invention relates to the field of sample joint inspection analysis devices of platforms, in particular to a multifunctional sample analysis system.
Background
In the field of in vitro diagnosis, a plurality of processes and a plurality of detection devices are generally required to be carried out on the same sample in the detection process, so that hospital clinical laboratories often have a plurality of detection devices at the same time to meet the requirements of hospital detection.
In a traditional detection system, different test systems are dispersed in different instruments, so that a plurality of samples need to be extracted and distributed to different machines, or one sample is moved to another machine for testing after the test of one instrument is completed, so that the detection time is prolonged, and great operation inconvenience is brought to detection personnel. In order to improve the detection efficiency, a hospital generally connects a plurality of devices together to form a pipeline mode, or a high-speed biochemical analyzer and a high-speed chemiluminescent immunoassay analyzer are integrated into a biochemical and immunological integrated machine. However, the above processing methods all have common disadvantages: the apparatus is bulky, requires a large space, and is extremely expensive in equipment cost, and hospitals or institutions with a slightly smaller sample amount or limited space are not well suited for the above detection mode.
Disclosure of Invention
The invention aims to solve at least one of the technical problems in the prior art and provides a multifunctional sample analysis system which has various detection types, small occupied space, convenient and quick instrument maintenance and operation, and can reduce the workload of sample transfer and reduce working errors.
The purpose of the invention is realized by adopting the following technical scheme:
a multi-functional sample analysis system comprising:
the sample storage device is used for storing samples;
the reaction reagent storage device is used for storing reaction reagents required by the reaction;
a chemiluminescent detection means for detecting a luminescent photometric reading of the sample reagent;
a biochemical detection device for detecting a biochemical photometric reading of the sample reagent;
a fluorescence detection device for detecting a fluorometric reading of the sample reagent;
and the sample adding device is used for adding the sample in the sample storage device and the reaction reagent in the reaction reagent storage device into the chemiluminescence detection device, the biochemical detection device and the fluorescence detection device.
Furthermore, the chemiluminescence detection device comprises a reaction cup conveying device for conveying the reaction cups one by one, a uniformly mixing device for uniformly mixing the samples and the reaction reagents in the reaction cups, a chemiluminescence incubation device for performing incubation reaction on the sample reagents in the reaction cups, a magnetic separation device for magnetic separation cleaning in a chemiluminescence reaction test, a carrying device for carrying the reaction cups loaded with the sample reagents, and a chemiluminescence reading device for detecting the reaction types of the sample reagents in the reaction cups.
Further, the reaction cup conveying device comprises a hopper for storing the reaction cups, a cup salvaging part for taking the reaction cups from the hopper, a conveying device for conveying the cup salvaging part, and a cup separating device for separating the reaction cups from the cup salvaging part.
Furthermore, the cup separating device comprises a supporting plate provided with a cup separating groove, a guide piece used for guiding the reaction cup to the cup separating groove, a push block used for being in contact with the reaction cup and a pushing driver used for driving the push block to move back and forth along the cup separating groove, the interval of the cup separating groove is smaller than the length of the reaction cup hanging lug, and one end of the cup separating groove is a dropping hole capable of accommodating the reaction cup to pass through.
Furthermore, the cup receiving device further comprises a cup receiving disc, a base and a rotating driver, wherein the cup receiving disc is used for receiving reaction cups falling from the falling holes, the base is used for bearing the cup receiving disc, the rotating driver is used for driving the cup receiving disc to rotate, a plurality of through holes corresponding to the reaction cups are formed in the cup receiving disc at intervals in an annular mode, and a cup outlet channel capable of accommodating the reaction cups is formed in the base corresponding to the through holes.
Further, the biochemical detection device comprises a biochemical incubation disc provided with a plurality of cuvettes, a stirring device used for uniformly mixing the samples in the cuvettes and the reaction reagents, a cleaning device used for cleaning the cuvettes, a biochemical reading device used for detecting the sample reagents in the cuvettes and a biochemical rotation driver used for driving the biochemical incubation disc to rotate, wherein the plurality of cuvettes are annularly arranged on the biochemical incubation disc at intervals, and the biochemical rotation driver can rotate to convey the cuvettes to corresponding stations of the stirring device, the cleaning device and the biochemical reading device.
Further, the stirring device comprises a stirring pin, a stirring rotating device used for driving the stirring pin to rotate and a stirring pin driver used for driving the stirring pin to move.
Furthermore, the fluorescence detection device comprises a card supply device for providing a fluorescence reagent card, a fluorescence incubation disc provided with a plurality of storage clamping positions corresponding to the fluorescence reagent card, a fluorescence rotating device for driving the fluorescence incubation disc to rotate, a photometry device for detecting the reading of the fluorescence reagent card and a reagent card transfer device for separating the detected fluorescence reagent card from the storage clamping positions and discarding the fluorescence reagent card, the fluorescence reagent cards are annularly and alternately arranged on the fluorescence incubation disc, and the fluorescence rotating device can convey the fluorescence reagent card to corresponding stations of the card supply device, the photometry device and the reagent card transfer device by rotating the fluorescence incubation disc.
Further, the reagent card transfer device comprises a pushing piece for pushing the reagent card, a pushing and moving device for driving the pushing piece to be close to or far away from the fluorescence incubation disc, and a jacking driver for driving the pushing piece to move up and down.
Furthermore, the sample storage device comprises a plurality of coaxially arranged sample storage trays and a sample rotating driver which is arranged corresponding to each sample storage tray and is used for driving the sample storage trays to rotate, and each sample storage tray is provided with a placing cavity for placing a sample tube.
Compared with the prior art, the invention has the beneficial effects that:
when the multifunctional sample analysis system is used, the sample storage device can suck a corresponding sample from the sample storage device through the sample adding device and place the sample into a bearing body of the detection device to be detected, then the sample adding device sucks a corresponding reaction reagent from the reaction reagent storage device and adds the reaction reagent into the bearing body of the corresponding detection device to react with the sample, and finally under the operation of the chemiluminescence detection device, the biochemical detection device and the fluorescence detection device, the multifunctional sample analysis system can realize the luminescence and photometry reading, the biochemical photometry reading and the fluorescence photometry reading aiming at each sample. This scheme is through above-mentioned setting, can be integrated to an organic whole with a plurality of testing platform, reduces the holistic occupation space of equipment, and the maintenance and the operation of instrument are all more convenient, can reduce the staff simultaneously and shift the time of sample at each instrument, improve work efficiency and reduce the error that the error produced.
Drawings
FIG. 1 is a schematic structural view of a preferred embodiment of the multifunctional sample analysis system of the present invention;
FIG. 2 is a top view of a preferred embodiment of the multi-functional sample analysis system of the present invention;
FIG. 3 is a schematic structural view of a preferred embodiment of the biochemical detection apparatus according to the present invention;
FIG. 4 is a schematic structural view of a preferred embodiment of the fluorescence detection device of the present invention;
FIG. 5 is a schematic structural diagram of a preferred embodiment of the sample adding device of the present invention.
Wherein, in the figures, the respective reference numerals:
10. a sample storage device;
20. a reaction reagent storage device;
31. a reaction cup conveying device; 32. A blending device; 33. a chemiluminescent incubation device; 34. a magnetic separation device; 35. a carrying device; 36. a chemiluminescent reader device;
41. a biochemical incubation tray; 42. a stirring device; 421. a stirring pin; 422. a stirring rotating device; 423. a stir pin driver; 43. a cleaning device; 44. a biochemical reading device;
51. a card supply device; 52. a fluorescence incubation tray; 521. storing and clamping positions; 53. a fluorescent rotating device; 54. a light measuring device; 55. a reagent card transfer device;
60. a sample adding device; 61. a sample adding needle; 62. and a sample application driver.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that any combination of the embodiments or technical features described below can be used to form a new embodiment without conflict.
The present invention, as shown in fig. 1-2, includes a sample storage device 10 for storing a sample, a reaction reagent storage device 20 for storing a reaction reagent required for a reaction, a chemiluminescence detection device for detecting a luminescence photometric reading of the sample reagent, a biochemistry detection device for detecting a biochemical photometric reading of the sample reagent, a fluorescence detection device for detecting a fluorescence photometric reading of the sample reagent, and a sample adding device 60, wherein the sample adding device 60 is used for adding the sample in the sample storage device 10 and the reaction reagent in the reaction reagent storage device 20 to the chemiluminescence detection device, the biochemistry detection device, and the fluorescence detection device. When the scheme is used, the sample storage device 10 can suck the corresponding sample from the sample adding device 60 and place the sample into a bearing body of a detection device needing to be detected, then the sample adding device 60 sucks the corresponding reaction reagent from the reaction reagent storage device 20 and adds the reaction reagent into the bearing body of the corresponding detection device to react with the sample, and finally under the operation of the chemiluminescence detection device, the biochemical detection device and the fluorescence detection device, the luminescence photometry reading, the biochemical photometry reading and the fluorescence photometry reading of each sample can be realized. Through the setting, a plurality of detection platforms can be integrated into a whole, the whole occupied space of equipment is reduced, the maintenance and the operation of the instrument are more convenient, meanwhile, the time for workers to transfer samples in each instrument can be reduced, the working efficiency is improved, and errors caused by errors are reduced.
As a preferred embodiment of the present invention, it may also have the following additional technical features:
in this embodiment, referring to fig. 5, the sample adding device 60 includes a sample adding needle 61 and a sample adding driver 62 for driving the sample adding needle 61 to operate. Wherein application of sample driver 62 can drive and strengthen the needle and realize the triaxial removal of XYZ, through above-mentioned setting, application of sample needle 61 can be accurate with sample and reaction reagent transport to the detection device who corresponds, and the flow is intelligent convenient more.
In this embodiment, as shown in fig. 1-2, the chemiluminescence detection apparatus includes a cuvette conveying apparatus 31 for conveying cuvettes one by one, a mixing apparatus 32 for uniformly mixing a sample in the cuvette with a reaction reagent, a chemiluminescence incubation apparatus 33 for performing incubation reaction on the sample reagent in the cuvette, a magnetic separation apparatus 34 for magnetic separation and cleaning in a chemiluminescence reaction test, a carrying apparatus 35 for carrying the cuvette carrying the sample reagent, and a chemiluminescence reading apparatus 36 for detecting the reaction type of the sample reagent in the cuvette. When the chemiluminescence detection device is used for detection, a reaction cup can be conveyed independently and orderly through the reaction cup conveying device 31, then the reaction cup is conveyed to the blending device 32 through the conveying device 35, then a sample and a reaction reagent are added under the action of the sample adding device 60 respectively, the blending device 32 is started to fully mix the sample and the reaction reagent, the reaction cup is conveyed to the chemiluminescence incubation device 33 through the conveying device 35 after mixing is completed for incubation, the sample reagent after magnetic separation is conveyed to the chemiluminescence reading device 36 through the conveying device 35 to be subjected to magnetic separation and cleaning after incubation is completed, and chemiluminescence detection of the sample can be completed by conveying the sample reagent after magnetic separation to the chemiluminescence reading device 36. Through the setting, the sample passes through behind a series of processes such as application of sample, mixing, incubation, magnetic separation, reading, just can accurately obtain the chemiluminescence detection of sample, and the detection data is accurate and operation degree of automation is high, completion that can be convenient fast detects.
In this embodiment, the chemiluminescent incubation device 33 and the magnetic separation device 34 both rotate to perform their own actions. Meanwhile, the chemiluminescence incubation device 33 is also provided with a heating device, so that a constant-temperature reaction environment of 37 ℃ in the incubation process is met, the incubation effect is better, and the specific heating device can realize the arrangement of the heating wire and the electric heating piece at the bottom of the chemiluminescence incubation device 33.
In this embodiment, the reaction cup conveying device 31 includes a hopper for storing reaction cups, a cup scooping member for taking reaction cups from the hopper, a conveying device for conveying the cup scooping member, and a cup guiding device for guiding reaction cups out of the cup scooping member. Wherein a plurality of disordered reaction cups are arranged in the hopper. When the reaction cup conveying device 31 works, the cup fishing piece is driven to pass through the hopper by starting the conveying device, the cup fishing piece is made to take one reaction cup, and finally the reaction cup is taken out through the cup guiding device, so that the ordered conveying of the reaction cups is completed. Through the arrangement, the conveying of the reaction cups can be automatically completed without manual participation, and the influence of manpower on detection results can be reduced while the working efficiency is high.
Combine above-mentioned reaction cup conveyor 31, in this embodiment, the structure of dragging for the piece sets up to the overhead hook form and only can drag for a reaction cup, and conveyor adopts gear drive's mode to realize carrying simultaneously, including a plurality of gears, drags for the piece and is provided with a plurality of and adjacent two and drags for a interconnect winding and form a closed loop on the gear. Through this structural design for conveyor all has one to drag for a reaction cup in can following the hopper when rotating at every turn, with this realization reaction cup high efficiency and orderly transport. The gear transmission can be designed into three gears which are in triangular distribution, and finally a plurality of fishing pieces form a right-angled triangular conveying structure after being connected around the three gears. Wherein the inclined plane section sets up to through the hopper section, conveniently drags for getting of piece to the reaction cup, and leads the cup device to set up on vertical section, makes things convenient for the reaction cup to receive the dead weight from dragging for in the piece and falls to leading on the cup device for drag for the better realization of piece of dragging for to the reaction cup drag for and separate.
In this embodiment, still include and divide the cup device, be equipped with the backup pad that divides the cup groove, be used for with the reaction cup guide divide the guide of cup groove, be used for with the ejector pad of reaction cup contact and be used for driving the ejector pad along divide the push driver of cup groove reciprocating motion, the interval that divides the cup groove is less than the length of reaction cup hangers, divide the one end in cup groove to be the hole that drops that can hold the reaction cup and pass through. Divide the cup device at the during operation, the reaction cup can fall into the branch cup groove of backup pad automatically under the effect of guide after dropping out from dragging for the piece, this moment because the hangers diameter of reaction cup self is greater than the diameter of its cup, the cup of reaction cup just can drop in dividing the cup groove, and receive the restriction of hangers and the below that can not drop, at last under the effect that promotes the driver, the ejector pad removes and promotes the reaction cup to the hole department that drops that divides the cup groove, accomplish dropping of reaction cup from this. Because the orientation of the reaction cup when the reaction cup is fished up by the fishing-up piece is not limited, the horizontal state of the reaction cup on the fishing-up piece can be changed into a vertical state with an upward opening through the arrangement of the cup separating device, so that the subsequent sample adding is facilitated, and the working efficiency is accelerated.
The reaction cup separating device is combined with the cup separating device, and the reaction cup separating device further comprises a baffle plate used for blocking the reaction cups from falling in the cup salvaging piece, so that the reaction cups cannot fall from the salvaging piece before reaching the guide piece, each reaction cup is ensured to firstly pass through the cup separating device, and the problem of orientation cannot occur.
Meanwhile, in the embodiment, a guide channel is further arranged between the falling hole and the cup receiving tray, a sensor for detecting whether a reaction cup exists in the guide channel is arranged in the guide channel, and the pushing driver acts according to detection information of the sensor. Through the arrangement of the guide channel, the reaction cup can accurately fall onto the guide cup device below after falling from the falling hole. Simultaneously through the setting of sensor, can accurately detect out the inside of direction passageway whether have a reaction cup, when no longer stopping in the direction passageway and having a reaction cup, the sensor just can send information to pushing away the driver and make it start, and it just can make the ejector pad slide to push into next reaction cup drop downtheholely to push away the driver at last, ensures that the reaction cup can be orderly carry.
In this embodiment, still include the guide cup device, specific structure includes: the cup receiving tray is used for receiving reaction cups falling from the falling holes, the base is used for bearing the cup receiving tray, and the rotating driver is used for driving the cup receiving tray to rotate. Guide the cup device at the during operation, the reaction cup can fall to connect in the through-hole on the cup dish along the direction passageway, this moment owing to connect cup dish below to be provided with the base, the reaction cup can not drop the below from the through-hole, simultaneously when the through-hole of direction passageway below has loaded when having reacted the cup, it just can start to drive and connects cup dish rotation to rotate the driver, make and connect next through-hole on the cup dish to aim at the direction passageway, and along with the rotation that connects the cup dish, the last through-hole all can be through the play cup passageway of base, the reaction cup just discharges that drops. Through the setting, the conveying speed of the falling reaction cups can be reduced, so that the reaction cups are conveyed more orderly, and the phenomenon that the reaction cups fall too fast and are collided and damaged is avoided.
In this embodiment, the carrying device 35 is a manipulator, and can stably clamp the reaction cups by the manipulator and convey the reaction cups to the stations of the devices.
In this embodiment, the mixing device 32 is driven by a motor to rotate the mixing column, so as to achieve a sufficient and uniform reaction between the sample and the reagent. Wherein mixing post rotation center sets up to have an eccentric distance with the reaction cup center, at last after motor drive mixing post rotary motion, can drive the eccentric mixing vibrations of reaction cup to improve the mixing effect, make sample and reactant misce bene and follow-up better reaction.
In this embodiment, the magnetic separation device 34 includes a support seat, a magnet mounting plate, a reaction cup tray, a needle frame, a first driving mechanism and a second driving mechanism, wherein the magnet mounting plate is fixedly connected to the top end of the support seat; the magnet mounting disc is provided with a plurality of first magnets and a plurality of second magnets, and the first magnets and the second magnets are circumferentially distributed at intervals around the central axis of the magnet mounting disc; the plurality of second magnets are positioned on the outer layer of the plurality of first magnets; the reaction cup tray is pivoted to the top end of the supporting seat and is positioned above the magnet mounting disc; the first driving mechanism is used for driving the reaction cup tray to rotate; the needle frame is arranged on the supporting seat and is positioned above the reaction cup tray; the needle frame can be driven by the second driving mechanism to move along the height direction of the supporting seat; the needle frame is provided with a liquid suction needle assembly and a liquid injection needle assembly. When the magnetic separation device 34 works, two layers of magnets can be distributed on the magnet mounting plate firstly, then the liquid injection needle assembly is used for injecting cleaning liquid into the reaction cup on the reaction cup tray, so that the reaction cup tray can be driven to rotate, and finally the inner layer of magnets and the outer layer of magnets on the magnet mounting plate can alternately perform inner and outer adsorption, dispersion and cleaning on magnetic combination materials in the reaction cup, so that the magnetic materials move in the cleaning liquid for multiple times and are adsorbed in multiple stages, the cleaning effect is improved, and the loss rate of magnetic beads is reduced.
In this embodiment, the chemiluminescent reading device 36 includes a measurement darkroom, a photon counter, and a waste liquid suction mechanism; the measurement darkroom is provided with an inlet and an outlet, a waste liquid suction port, a reaction liquid inlet and a photometric channel; a conveying mechanism, a cup carrying block and a shading block are arranged in the measurement darkroom, and the cup carrying block is used for moving along the conveying direction of the conveying mechanism under the conveying action of the conveying mechanism; the inlet and outlet, the waste liquid suction port and the reaction liquid inlet are sequentially arranged at intervals along the conveying direction of the conveying mechanism; the photometric channel is arranged below the reaction liquid inlet and is positioned in the conveying direction of the conveying mechanism; the photon counter is arranged outside the measurement darkroom, and a probe of the photon counter corresponds to one end of the photometric channel; the other end of the photometric channel is communicated to the inside of the measurement darkroom; the light shielding block can move towards the end part close to or far away from the light measuring channel; the light shielding block is used for plugging the end part of the light measuring channel after moving towards the end part close to the light measuring channel; the shading block is positioned on the motion track of the cup carrying block and is driven by the cup carrying block to move towards the end part far away from the light measuring channel; the waste liquid suction mechanism can extend into the measurement darkroom from the waste liquid suction port. According to the scheme, the sample reagent to be measured can be placed on the cup carrying block through the inlet and the outlet after being filled into the reaction cup, and sequentially reaches the waste liquid absorbing port under the driving of the conveying mechanism to absorb waste liquid; and the whole process is carried out in a measurement darkroom, the light-shielding effect is higher, and the measurement accuracy is higher.
In this embodiment, referring to fig. 3, the biochemical detection device includes a biochemical incubation disc 41 provided with a plurality of cuvettes, a stirring device 42 for uniformly mixing the sample in the cuvette with the reaction reagent, a cleaning device 43 for cleaning the cuvette, a biochemical reading device 44 for detecting the sample reagent in the cuvette, and a biochemical rotation driver for driving the biochemical incubation disc 41 to rotate, the plurality of cuvettes are annularly and alternately arranged on the biochemical incubation disc 41, and the biochemical rotation driver can rotate to convey the cuvette to corresponding stations of the stirring device 42, the cleaning device 43, and the biochemical reading device 44. When the biochemical detection device works, a biochemical sample and a reaction can be correspondingly added into a cuvette of the biochemical incubation tray 41 through the sample adding device 60, then the biochemical rotation driver is started to drive the whole biochemical incubation tray 41 to rotate and rotate the cuvette to a stirring station of the stirring device 42, the biochemical sample can be incubated and reacted on the cuvette after stirring is completed, after incubation is completed, the biochemical sample can rotate to a detection station of the biochemical reading device 44 under the action of the biochemical rotation driver to perform photometric reading, and finally, after reading detection is completed, the biochemical sample can be directly rotated and conveyed to the cleaning device 43. Through the setting, the sample is through the application of sample, stirring, hatch, behind a series of processes such as reading, washing, just can accurately obtain the biochemical photometry reading of sample, and the detection data is accurate and operation degree of automation is high, can be fast convenient completion detect.
In this embodiment, referring to fig. 5, the stirring device 42 includes a stirring pin 421, a stirring rotation device 422 for driving the stirring pin 421 to rotate, and a stirring pin driver 423 for driving the stirring pin 421 to move. With the above arrangement, the stirring pin 421 is driven by the stirring pin driver 423 to descend into the cuvette, and finally the stirring rotating device 422 is started to drive the stirring pin 421 to rotate, so that the sample and the reaction reagent are uniformly mixed. The stirring pin 421 is also fixed on the stirring rotating device 422 in an eccentric manner, thereby achieving a better stirring effect.
In combination with the arrangement of the stirring device 42, a cleaning tank for cleaning the stirring pin 421 is further provided in this embodiment. Through the setting of wasing the pond, but the position of stirring needle 421 rotation to the battle array washing pond is moved before the drive of stirring needle driver 423, is wasing stirring needle 421 through reciprocating lift removal at last, can avoid stirring needle 421 to pollute other samples after the repetitious usage from this. Similarly, in the chemiluminescence detection device, cleaning pools can be arranged near the mixing column of the mixing device 32 and near the sample suction needle of the sample adding device 60, and cleaning can be carried out after the contact with the sample and the reaction reagent every time, so that the pollution to other samples and the influence on the accuracy of sample detection can be prevented.
In this embodiment, referring to fig. 4, the fluorescence detection device includes a card supply device 51 for providing a fluorescence reagent card, a fluorescence incubation disc 52 having a plurality of storage positions 521 corresponding to the fluorescence reagent card, a fluorescence rotation device 53 for driving the fluorescence incubation disc 52 to rotate, a photometry device 54 for detecting readings of the fluorescence reagent card, and a reagent card transfer device 55 for separating the detected fluorescence reagent card from the storage positions 521 and discarding the fluorescence reagent card, wherein each fluorescence reagent card is annularly and intermittently disposed on the fluorescence incubation disc 52, and the fluorescence rotation device 53 can transfer the fluorescence reagent card to corresponding stations of the card supply device 51, the photometry device 54, and the reagent card transfer device 55 by rotating the fluorescence incubation disc 52. When the fluorescence detection device is used, firstly, the fluorescence reagent card to be reacted is pushed to the storage clamping position 521 corresponding to the fluorescence incubation disc 52 by the card supply device 51, then, the corresponding sample is added on the fluorescence reagent card by the sample adding device 60, so that the sample completes the binding reaction in the reagent card and carries out the incubation for a corresponding time, at this time, the incubated reagent card is conveyed to the photometry device 54 for fluorescence reading, and finally, the fluorescence reagent card which completes the reading is taken out from the storage clamping position 521 under the action of the reagent card transfer device 55 and discarded, so that the detection of the fluorescence reading of the sample is completed. Through the setting, after a series of processes such as application of sample, incubation, reading, taking out and abandoning, fluorescence reagent card just can accurately obtain the fluorescence photometry reading of sample, and the detection data is accurate and the degree of automation of operation is high, completion that can be convenient fast detects.
In this embodiment, the reagent card transferring device 55 includes a pushing member for pushing the reagent card, a pushing and moving device for driving the pushing member to move close to or away from the fluorescence incubation tray 52, and a jacking driver for driving the pushing member to move up and down. Through the arrangement, after the fluorescent reagent card is detected, the fluorescent incubation disc 52 can be rotated through the fluorescent rotating device 53 to rotate the detected reagent card to the station of the reagent card transferring device 55, at the moment, the jacking driver drives the pushing piece to jack up and lift, so that the pushing piece is higher than the reagent card and is positioned at the tail end of the reagent card, finally, the pushing moving device is started again to drive the pushing piece to move away from the fluorescent incubation disc 52, so that the reagent card can be pushed out in the middle of the moving process, the detected reagent card is extracted and discarded, and the storage clamping position 521 on the fluorescent incubation disc 52 can be put into the next detection.
In this embodiment, referring to fig. 1-2, the sample storage device 10 includes a plurality of sample storage trays coaxially disposed, and a sample rotation driver disposed corresponding to each sample storage tray and configured to drive the sample storage trays to rotate, where each sample storage tray is provided with a placement cavity for placing a sample tube. Through the setting of a plurality of sample storage discs, make this analytic system can deposit the sample of a plurality of types simultaneously, can carry out the while detection of multiple sample, set up the rotation driver in addition to each sample storage disc and make sample storage disc can rotate from this, prevent that different application of sample device 60 from taking place to interfere when the sample, reduce other detection device's detection efficiency.
The above additional technical features can be freely combined and used in superposition by those skilled in the art without conflict.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. A multi-functional sample analysis system, comprising:
a sample storage device (10) for storing samples;
a reaction reagent storage device (20) for storing reaction reagents required for the reaction;
a chemiluminescent detection means for detecting a luminescent photometric reading of the sample reagent;
a biochemical detection device for detecting a biochemical photometric reading of the sample reagent;
a fluorescence detection device for detecting a fluorometric reading of the sample reagent;
and the sample adding device (60) is used for adding the sample in the sample storage device (10) and the reaction reagent in the reaction reagent storage device (20) into the chemiluminescence detection device, the biochemical detection device and the fluorescence detection device.
2. The multifunctional sample analysis system according to claim 1, wherein the chemiluminescence detection apparatus comprises a cuvette conveying apparatus (31) for conveying cuvettes one by one, a homogenizing apparatus (32) for uniformly mixing the sample and the reaction reagent in the cuvette, a chemiluminescence incubation apparatus (33) for performing incubation reaction on the sample reagent in the cuvette, a magnetic separation apparatus (34) for magnetic separation and cleaning in a chemiluminescence reaction test, a carrying apparatus (35) for carrying the cuvette carrying the sample reagent, and a chemiluminescence reading apparatus (36) for detecting the reaction type of the sample reagent in the cuvette.
3. A multifunctional sample analysis system according to claim 2, wherein said cuvette conveyor (31) comprises a hopper for storing cuvettes, a scoop for taking cuvettes from said hopper, a conveyor for conveying said scoop and a cup divider for dividing cuvettes from said scoop.
4. The multifunctional sample analysis system as claimed in claim 3, wherein the cup dividing device comprises a support plate provided with cup dividing grooves, a guide member for guiding the reaction cups to the cup dividing grooves, a push block for contacting the reaction cups, and a push driver for driving the push block to move back and forth along the cup dividing grooves, the intervals of the cup dividing grooves are smaller than the length of the reaction cup hanging lugs, and one ends of the cup dividing grooves are dropping holes capable of accommodating the reaction cups.
5. The multifunctional sample analysis system as claimed in claim 4, further comprising a cup receiving tray for receiving reaction cups dropped from the drop holes, a base for carrying the cup receiving tray, and a rotation driver for driving the cup receiving tray to rotate, wherein a plurality of through holes corresponding to the reaction cups are formed in the cup receiving tray at intervals, and a cup outlet channel capable of accommodating the reaction cups is formed in the base corresponding to the through holes.
6. The multifunctional specimen analysis system according to claim 1, wherein the biochemical detection device comprises a biochemical incubation tray (41) provided with a plurality of cuvettes, a stirring device (42) for uniformly mixing the specimen in the cuvette with the reaction reagent, a cleaning device (43) for cleaning the cuvette, a biochemical reading device (44) for detecting the specimen reagent in the cuvette, and a biochemical rotation driver for driving the biochemical incubation tray (41) to rotate, wherein the plurality of cuvettes are annularly and intermittently arranged on the biochemical incubation tray (41), and the biochemical rotation driver can rotationally convey the cuvette to corresponding stations of the stirring device (42), the cleaning device (43), and the biochemical reading device (44).
7. Multifunctional sample analysis system according to claim 6, wherein the stirring means (42) comprises a stirring pin (421), a stirring rotation means (422) for driving the stirring pin (421) in rotation, and a stirring pin driver (423) for driving the stirring pin (421) in movement.
8. The multifunctional sample analysis system according to claim 1, wherein the fluorescence detection device comprises a card supply device (51) for supplying fluorescence reagent cards, a fluorescence incubation disc (52) provided with a plurality of storage screens (521) corresponding to the fluorescence reagent cards, a fluorescence rotation device (53) for driving the fluorescence incubation disc (52) to rotate, a photometry device (54) for detecting the readings of the fluorescence reagent cards, and a reagent card transfer device (55) for separating the detected fluorescence reagent cards from the storage screens (521) for discarding, wherein each fluorescence reagent card is annularly and intermittently arranged on the fluorescence incubation disc (52), the fluorescence rotating device (53) can convey the fluorescence reagent card to corresponding stations of the card supply device (51), the photometry device (54) and the reagent card transfer device (55) by rotating the fluorescence incubation disc (52).
9. Multifunctional sample analysis system according to claim 8, wherein the reagent card transfer means (55) comprise a pusher for pushing a reagent card, a pushing movement means for driving the pusher towards or away from the fluorescence incubation disc (52), and a jack-up drive for driving the pusher to move up and down.
10. The multifunctional specimen analysis system according to claim 1, wherein the specimen storage device (10) comprises a plurality of coaxially arranged specimen storage trays, each of which is provided with a placement chamber for placing a specimen tube, and a specimen rotation driver provided corresponding to each of the specimen storage trays and for driving the specimen storage trays to rotate.
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Cited By (1)
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Application publication date: 20220311 |