CN105181591A - Biochemical immune mixed analysis system and device - Google Patents
Biochemical immune mixed analysis system and device Download PDFInfo
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- CN105181591A CN105181591A CN201510467986.8A CN201510467986A CN105181591A CN 105181591 A CN105181591 A CN 105181591A CN 201510467986 A CN201510467986 A CN 201510467986A CN 105181591 A CN105181591 A CN 105181591A
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Abstract
Belonging to medical diagnosis, especially the in vitro diagnosis field, the invention discloses a dry type biochemical immune mixed analysis system and a device thereof. The mixed analysis system includes a dry type biochemical and immune detection system able to individually or simultaneously complete biochemical and immune detection, and the system includes mixed type and parallel type two modes. The system device involved in the invention is combined by a support base plate, a reagent strip storage unit, a sample addition unit, a sample unit, a detection unit, and a circuit unit, and includes single reaction disk and double-reaction disk two forms. Specifically, the single reaction disk can complete biochemical and immune analysis mixedly, the double reaction disks correspond to biochemical and immune analysis procedures respectively, and the detection process of the two can be finished integratedly. According to the invention, between-sample pollution is effectively reduced, compared with single biochemical type or immune type, the system and the device greatly increase the number of detection items, and have the characteristics of fast detection speed and small blood collection amount, thus reducing the patient pain in the detection process.
Description
Technical field
The invention belongs to extracorporeal diagnostic system and device field in diagnostic medical apparatus, spy relates to a kind of Dry-type biochemical immunity hybrid analysis system and device.
Background technology
Biochemical analysis is one of conventional important means of clinical diagnosis.By measuring various biochemical indicator to the analysis of blood or other body fluid, comprehensively analyze in conjunction with other clinical datas, can assisted diagnosis disease, evaluation is made to organ dysfunction, and benchmark of complicating factors and treatment after determining etc. can be differentiated.
Biochemical Analyzer is mainly used in clinical blood, the biochemistry of other humoral samples and chemical composition as the quantitative measurement of haemoglobin, cholesterol, triglyceride, albumin, C reactive protein, glucose, potassium, sodium, calcium etc., is one of the most frequently used detecting instrument of clinical analysis.
Due to clinically, the sample size of check analysis increases sharply, and new Interventions Requested constantly increase, and traditional manual manipulation method can not meet clinical demand.Therefore, various biochemical analyzer obtains and develops on a large scale very much.In general, whether be solid state reaction with reagent generation chemical reaction per sample, Biochemical Analyzer can be divided into common (wet-chemical formula) and dry chemical formula Biochemical Analyzer.
Dry chemical, adopt the solid-phase reagent technology of multilayer film, as long as fluid sample is added to the reagent carrier solidified in special construction, in the reagent of i.e. dry type, with the water in sample for solvent, by after the agent dissolves that is solidificated on carrier, then carry out chemical reaction with the composition to be measured in sample, thus carry out analysis and measure.
And corresponding, wet-chemical, namely common chemical reaction, then add liquid reagent and sample in reaction vessel, the chemical reaction occurred after mixing.
Successfully produce in the world after First automatic clinical chemistry analyzer from Technicon company of the U.S. in nineteen fifty-seven, the automatic clinical chemistry analyzer that various model is different with function continues to bring out, and the robotization for hospital clinical biochemical investigation has stepped a very important step.Since the fifties, skeggs introduced a kind of principle of clinical biochemical analyser first, along with the especially medical science applied development of science and technology, various automatic biochemical analyzer and diagnostic reagent have all had and have developed on a large scale very much, different according to the structural principle of instrument, can be divided into: continuous flowing type (duct type), discrete, separate type and dry sheet type four class.
At present, clinical treatment mechanism generally uses discrete Biochemical Analyzer, instrument is by sample disc, reagent rack, sample pipetting volume device, reagent pipetting volume device, reaction tray, colorimetric device, reaction cup cleaning device, stirring apparatus, ISE assembly and operating system form, as Shenzhen steps auspicious BS-120 automatic clinical chemistry analyzer, the NSA-300 type automatic clinical chemistry analyzer of Shenyang Neusoft, the FAITH series automatic clinical chemistry analyzer of Nanjing Laura, assay method is various, wavelength coverage is wide, analysis speed is fast, precision is high, reproducible, test event is many.In recent years, Dry-type biochemical instrument operates the features such as rapid and convenient and is rapidly developed due to it, as the ReflotronPlus type Dry-type biochemical instrument of Roche, the 4000ie fully-automatic dry type Biochemical Analyzer of FUJIFILM, this quasi-instrument adopts the method for dry chemical, only sample need be added on the dry reagent strip of solid phase carrier during use and can carry out subsequent measurements, without the need to traditional pipe system.Dry reagent strip structure is generally divided into diffusion layer, filtering layer, reagent layer, color layer and supporting layer from top to bottom, and patent CN200920078032.8, US7625721, US7494818, US6524864, CN201310216838.X describe the detailed construction distribution of multiple dry reagent strip respectively.
Immunological assay method is numerous, and the measuring principle that current automatic lmunoassays analyzer adopts mainly contains immunoturbidimetry, fluorescence immune chromatography, fluorescence polarization, collaurum, enzyme linked immunological and chemiluminescence etc.Wherein immunoturbidimetry sensitivity is lower, only for measuring the higher material of the in-vivo content such as C reactive protein, Complement C_3/C4; Fluorescence immune chromatography sensitivity is higher, reagent is also comparatively stable, the fluorescence immunoassay that product as Ji Dan biotech inc full-automatic fluorescence immunoassay quantitative analysis instrument Getein1600, patent No. CN201410836485.8 can complete multiple project simultaneously detects; Fluorescence polarization method is homogeneous assay method, precision is high, analysis speed is fast, does not affect by sample of color and cloudy state, as the TDx line fluorescent polarization analysis instrument of U.S. Abbott, but this method is confined to the antigen that determining molecular weight is less than 160KD at present, and susceptibility is not high; Collaurum has higher sensitivity and specificity, and detection time is short, usually only needs about 15 minutes, and testing process is simple, but usually can only the property estimated interpretation, affect greatly, and cost is higher by subjective factor; Chemical illumination immunity analysis instrument is at present popular immunoassay instrument, and its detection sensitivity is strong, specificity is high, sample throughput is large, simple and efficient to handle, in immunology detection, obtains application widely.
In clinical practice, a patient often needs to carry out biochemistry and immune detection simultaneously, way general at present sample is put into respectively the instrument of biochemical analysis and immunoassay, not only need two large-scale instruments, and patient's blood sampling volume is many, more painfully brings to patient, for the patient that condition is bad, too much blood sampling is unfavorable to patient, detects simultaneously and also needs to spend the more time, have a strong impact on the diagnosis of patient.
Based on above factor, biochemistry and immune detection are combined, form biochemical immunity integral type detection system.Patent CN2847292Y discloses a kind of Full-automatic biochemical immunity analysis instrument, both can carry out independent wet type biochemistry detection or immune detection, can carry out again wet type biochemistry and immune detection simultaneously; The DimensionEXL of biochemical immunity analyser UniCelDXC600i, Siemens company production of BeckmanCoulter company, the immunity being the biochemistry of wet type and wet type is the biochemical immunity detection system that combines of chemiluminescence immune assay particularly, the VITROS5600 Full-automatic biochemical immunity analysis instrument of Johson & Johnson, be aly integrate dry, the detecting instrument of wet-chemical and chemiluminescence three kinds of analytical technologies.The dry analysis system of this instrument adopts multicoat thin film technique and reflected light analytical approach, and its detection speed is fast, is highly suitable for emergency treatment inspection.Also comprising the domestic patent No. is in addition that CN201310312544.7, CN201110005816.X all disclose a kind of Full-automatic biochemical immunity analysis instrument, and these two devices are the system of the biochemical and wet type immunity combination of wet type, as easy as rolling off a logly pollutes.
Dry-type biochemical and immunochromatography do not need pipe system, and it is very convenient to operate, but the confluence analysis system also Dry-type biochemical and immunochromatography not combined in the market, this direction market application foreground is huge.
Summary of the invention
The object of this invention is to provide a kind of biochemical immunity hybrid analysis system, Dry-type biochemical and immune detection combine by this system, complete respectively and detect separately or complete two kinds of testing processes simultaneously.Greatly improve the detection flux of system, realize disease syndrome diagnosis, formulate the object of fast treating scheme.
The object of this invention is to provide the device of said system, comprise two reaction tray devices of integrated single reaction dish device and block form.
The object of this invention is to provide a kind of detection method and light channel structure of Dry-type biochemical reagent strip of multi objective, realize detecting while multi objective in the same reagent bar in biochemical analysis, significantly promote detection rates.
The present invention is achieved through the following technical solutions:
A kind of biochemical immunity hybrid analysis system, comprises Dry-type biochemical and immune system, it is characterized in that Dry-type biochemical and immune system are incorporated into a system, simultaneously or analyze separately, completes sample variation and detects.
Described analysis type comprises whole Dry-type biochemical and immunoassay type, preferred dry biochemistry, micro-current control biochemical, fluorescence immunoassay, micro-fluidic immunity, colloid gold immune, the immunity of colored latex.
Described analysis indexes comprises single index reagent analysis and multi objective associating reagent analysis.
In an embodiment, described Dry-type biochemical and dry type immunity is module integrated runs in a new commingled system.
In another embodiment, described Dry-type biochemical and dry type immunity module arranged side by side, the isolated operation in same system of two modules.
Described module includes reagent strip and stores and loading unit, reaction tray unit, sample unit, application of sample unit, detecting unit and circuit control unit.
New commingled system stores biochemical and/or immunoreagent bar, and after system cloud gray model, reagent strip is loaded on reaction tray unit, after application of sample unit inhales sample, process, application of sample is in reagent strip, in reaction tray, complete reaction, enter detecting unit and complete detection, draw testing concentration.
Coordinate system stores biochemical and immunoreagent bar separately, and after system cloud gray model, reagent strip is loaded on reaction tray unit, after application of sample unit inhales sample, process, application of sample is in reagent strip, in reaction tray, complete reaction, enter each module of detecting unit and complete detection, draw testing concentration.
Described detection comprises colorimetric determination, CCD detects and fluoroscopic examination, and wherein fluoroscopic examination object comprises fluorescence immunoassay and micro-fluidic immunity; Colorimetric determination or CCD detected object comprise the immunity of Dry-type biochemical, micro-current control biochemical, colloid gold immune and colored latex.
Detect sample type and comprise whole blood, serum, blood plasma, urine, saliva, abdomen liquid, cerebrospinal fluid, complete full-automatic pre-treatment operation after described sample loading system, before loading, do not need pre-treatment.
As a device for said system, comprise single reaction dish and two reaction tray two kinds of forms, include support baseboard, reagent strip stores and loading unit, reaction tray unit, sample unit, application of sample unit, detecting unit and circuit control unit:
In single reaction dish device:
1) support baseboard is to system support with fixing, and according to each unit position distribution on base plate, base plate is divided into former and later two regions;
2) sample unit is positioned at side, base plate proparea, comprises sample area, consumptive material district and treatment region;
3) reaction tray unit is positioned at base plate proparea opposite side, comprises rotating disk and electric machine assembly;
4) application of sample unit is positioned at above sample and reaction tray unit, comprises robot assemblies, suction nozzle pick-up and sample-adding pump;
5) reagent strip storage and loading unit are surrounded on outside reaction tray unit, and comprise bracket component, storage box assembly and charging assembly, storage box is fixed in bracket component, and charging assembly is positioned at below support and storage box;
6) detecting unit is positioned at reagent strip storage and loading unit side, comprises light source, lens class component and signal receiving device, completes biochemical and immunoreactive detection;
7) circuit control unit comprises power supply, control and treatment element, and each element electrical connection, control system is run.
In two reaction tray device:
1) support baseboard is to system support with fixing, according to each unit position distribution on base plate, base plate is divided into former and later two regions;
2) sample unit is positioned at base plate proparea central authorities, comprises sample area, consumptive material district and treatment region;
3) reaction tray unit two reaction tray is positioned at the sample unit left and right sides, comprises rotating disk and electric machine assembly;
4) application of sample unit is positioned at above sample and reaction tray unit, comprises mechanical arm, suction nozzle pick-up and sample-adding pump;
5) reagent strip storage and loading unit are surrounded on outside reaction tray unit, and comprise bracket component, storage box assembly and charging assembly, storage box is fixed in bracket component, and charging assembly is positioned at below support and storage box;
6) detecting unit is positioned at reagent strip storage and loading unit side, comprises light source, lens class component and signal receiving device, completes biochemical and immunoreactive detection;
7) circuit control unit comprises power supply, control and treatment element, and each element electrical connection, control system is run.
Described sample unit is box body, support baseboard slides into, skid off and fixes, and box plate is arranged successively removable sample cell, dilution liquid bath, disposable tip box, mixing box and suction nozzle recycling box.
Described reaction tray unit rotary disc assembly is discoid, and edge has multiple reagent strip fixed bit, with dial rotation, completes the process of its carrying reagent strip application of sample, detection.
Described application of sample unit comprises XYZ mechanical arm, suction nozzle pick-up and sample-adding pump, in XYZ mechanical arm, X arm is positioned at circuit control unit top, Y arm horizontal vertical is in X arm, slide along X arm, Z arm, vertically perpendicular to Y arm, slides along Y arm, moves up and down simultaneously, Z arm bottom connects suction nozzle pick-up, connects sample-adding pump simultaneously; XYZ mechanical arm also optional a kind of both arms form in described pair of reaction tray device, X arm has two Y arms slide, completes the application of sample to independent reaction tray separately.
Described reagent strip stores and loading unit comprises bracket component, storage box assembly and charging assembly, bracket component is surrounded on outside reaction tray unit, storage box assembly is removably placed on bracket component, charging assembly is positioned at bottom support and storage box, comprise motor and hook, link up with and reagent strip is hooked reaction tray reagent strip fixed bit from storage box.
Described storage box assembly is sealing box body, and multiple reagent strip is sequentially stacked in box, and bottom box body, there is opening side, and reagent strip is hooked reaction tray reagent strip fixed bit by opening by elastic hook, and opening sets back, and keeps the sealing of box body; Described storage box assembly has reagent strip information identification reading assembly, comprises sensor and signal transmission unit, and identification agent bar kind of information also transfers to control element.
Described detecting unit to store and between loading unit and circuit control unit at reagent strip, and detecting pattern can select colourimetry or CCD to detect or one or more in immune detection, and wherein fluoroscopic examination object comprises fluorescence immunoassay and micro-fluidic immunity; Colorimetric determination or CCD detected object comprise Dry-type biochemical analysis, micro-current control biochemical analysis, colloid gold immune and the immunity of colored latex.
Described colorimetric determination light path comprises light source, lens, optical filter or filter wheel or grating, detection zone and photo-translating system, during detection, light source luminescent is through lens, optical filter or filter wheel or grating expose to surveyed area, be photoelectrically converted after reflection systematic collection, draw index concentration as calculated, wherein, single index detection employing optical filter leaches the Single wavelength incident light needed for index, multi objective associating reagent strip detection employing filter wheel or grating leach the multiple Single wavelength incident lights needed for multiple index, the Single wavelength optical filter that on described filter wheel, evenly distributed multiple index to be measured is corresponding.
Described fluorescence immunoassay detects light path and comprises excitation source, lens, detection zone, lens, photo-translating system, during detection, light source is launched exciting light and is exposed to detection zone through lens, slit, fluorescent material excitation-emission fluorescence, be photoelectrically converted systematic collection after lens, calculates index concentration to be measured; Wherein, when carrying out single index and detecting, above-mentioned light path is adopted; When carrying out multi objective joint-detection, fluorescence separates through two-phase dichronic mirror the systematic collection that to be photoelectrically converted after each Single wavelength light again after lens, calculates the concentration of multi objective.
Said apparatus outside comprises housing, and housing is provided with touching type operation platform.
Beneficial effect of the present invention
Dry-type biochemical and immune detection are integrated in the same apparatus by the present invention, Dry-type biochemical and immune detection or can be completed separately simultaneously, more independent Dry-type biochemical or immune detection, substantially increase number of inspection items, detection speed is fast simultaneously, blood sampling volume is few, reduces the misery of sufferer in testing process.
The present invention's biochemistry and immune detection all adopt dry sheet type reagent strip, there is not liquid light channel structure in device, application of sample unit has disposable tip pick-up simultaneously, utilizes disposable TIP head, effectively prevent the pollution problem between sample, Indexs measure accuracy is very high.
In the present invention, in an embodiment, two reaction tray module shares a sample unit, uses dual arm system, and utilize two XYZ arms to biochemical and immune response dish application of sample simultaneously, more traditional single armed system, application of sample efficiency improves greatly, and detection speed is accelerated greatly.
Reagent strip of the present invention stores and load-on module comprises water-tight equipment and dry hole automatically, can store dry sheet type biochemistry and immunoreagent bar for a long time.Utilize simultaneously and automatically load and reagent strip identification module, can intelligentized recognition detection project, automatically the operation such as application of sample, detection is carried out, special in single reaction dish structure, can recognition reaction dish position mesophytization or immunoreagent bar fast, and then the judgement of the step such as application of sample, detection, greatly accelerate detection speed and accuracy.
In the present invention, Dry-type biochemical and immune hybrid analysis device can complete the detection of all Dry-type biochemical and immunoassay type, comprise the various ways such as micro-current control biochemical, micro-fluidic immunity, Dry-type biochemical, fluorescence immune chromatography, colored latex immunochromatography, colloidal gold immunochromatographimethod.
Accompanying drawing explanation
Fig. 1 is single-deck system embodiment schematic diagram of the present invention
Fig. 2 is single-deck system embodiment vertical view of the present invention
Fig. 3 is single-deck system embodiment base plate figure of the present invention
Fig. 4 is double plate dual arm system embodiment schematic diagram of the present invention
Fig. 5 is double plate dual arm system embodiment vertical view of the present invention
Fig. 6 is double plate dual arm system embodiment base plate figure of the present invention
Fig. 7 is double plate single armed system embodiment schematic diagram of the present invention
Fig. 8 is inventive samples cell schematics
Fig. 9 is reaction tray cell schematics of the present invention
Figure 10 is application of sample cell schematics of the present invention
Figure 11 is that reagent strip of the present invention stores and automatic loading unit schematic diagram
Figure 12 is reagent strip storage box position assumption diagram of the present invention
Figure 13 is reagent strip storage box outside drawing of the present invention
Figure 14 is reagent strip storage box interior view of the present invention
Figure 15 is that multi objective Dry-type biochemical of the present invention detects index path
Figure 16 is that multi objective immunochromatography of the present invention detects index path
In figure, 1 is single-deck system backplane, 1 ' is double plate dual arm system base plate, 1 " be double plate single armed system backplane, 2 is single-deck system sample unit, 2 ' is double plate dual arm system sample unit, 2 " be double plate single armed system sample unit, 3 is single-deck system response dish unit, 3 ' is double plate dual arm system reaction tray unit, 3 " be double plate single armed system response dish unit, 4 is single-deck system application of sample unit, 4 ' is double plate dual arm system application of sample unit, 4 " be double plate single armed system application of sample unit, 5 is single-deck system reagent strip storage unit and loading unit, 5 ' is double plate dual arm system reagent strip storage unit and loading unit, 5 " be double plate single armed system reagent strip storage unit and loading unit, 6 is single-deck systems axiol-ogy unit, 6 ' is double plate dual arm system detecting unit, 6 " be double plate single armed systems axiol-ogy unit, 7 is single-deck circuit system control module, 7 ' is double plate dual arm system circuit control unit, 7 " be double plate single armed circuit system control module, 201 is specimen holder, 202 is dilution frame, 203 is rail plate, 204 is suction nozzle recycling box, 205 is disposable tip box, 206 is mixing box, 207 is barcode scanner, 301 is reagent strip fixed bit, 302 is electric machine assembly, 401 is X arm, 402 is Y arm, 403 is Z arm, 501 family's assemblies for it, 502 is kit components, 503 is charging assembly, 504 is information identification reading assembly, 505 is fixing padlock, 5021 is kit lid, 5022 is kit, 5023 is elastic opening, 5024 is open slot, 5025 is reagent strip, 5026 is reagent strip decline guide rail, 601 is biochemical detection light source, 602 is lens, 603 is filter wheel, 604 is detection zone, 605 is Signal reception district, 606 is fluoroscopic examination light source, 607 is collimating mirror, 608 is lens, 609 is detection zone, 610 is double lens, 611 is two-phase dichronic mirror, 612 is filtering apparatus, 613 is Signal reception district, 614 is total reflective mirror.
Specific embodiments
Below in conjunction with accompanying drawing; a kind of Dry-type biochemical immunoassay system of the present invention and device are described in detail and are introduced; object is in order to the public better understands described system and device; but not the restriction to described technical scheme; with on the basis of system of the present invention and device; improvement to described structure and the increase and decrease to described assembly or replacement, as long as play identical function and efficacy, all within the present patent application technical scheme required for protection.
Embodiment one:
A kind of biochemical immunity hybrid analysis of the present patent application system, comprise Dry-type biochemical and dry type immune system, Dry-type biochemical and dry type immune system are incorporated into a system, simultaneously or analyze separately, complete sample variation and detect.
The analysis type of present system comprises whole Dry-type biochemical and immunoassay type, preferred dry biochemical analysis, micro-current control biochemical analysis, fluorescence immune chromatography, Microfluidic Immunoassay, colloidal gold immunochromatographimethod, colored latex immunochromatography.
Present system analysis adopts dry type reagent strip to analyze, and reagent strip type comprises single index reagent analysis and multi objective associating reagent analysis.
Wherein Dry-type biochemical and dry type immunity is module integrated runs in a new commingled system in a kind of embodiment.
In another kind of embodiment, Dry-type biochemical and dry type immunity module are side by side, the isolated operation in same system of two modules.
In two kinds of above-mentioned embodiments, present system includes reagent strip storage and loading unit, reaction tray unit, sample unit, application of sample unit, detecting unit and circuit control unit.
Commingled system new in the first embodiment stores biochemical and/or immunoreagent bar, and after system cloud gray model, reagent strip is loaded on reaction tray unit, after application of sample unit inhales sample, process, application of sample is in reagent strip, in reaction tray, complete reaction, enter detecting unit and complete detection, draw testing concentration.
In the second embodiment, coordinate system stores biochemical and immunoreagent bar separately, and after system cloud gray model, reagent strip is loaded on reaction tray unit, after application of sample unit inhales sample, process, application of sample is in reagent strip, in reaction tray, complete reaction, enter each module of detecting unit and complete detection, draw testing concentration.
The detecting unit of two kinds of above-mentioned embodiments comprises fluorescence immune chromatography detection, CCD detects, raster pattern detects and the wheeled detection that filters, and wherein fluorescence immune chromatography detected object comprises fluorescence immune chromatography and micro-fluidic immunity; Wheeled or the raster pattern of filtering or CCD detected object comprise Dry-type biochemical analysis, micro-current control biochemical analysis, colloidal gold immunochromatographimethod and colored latex immunochromatography.
The detection sample type of analytic system of the present invention comprises whole blood, serum, blood plasma, urine, saliva, abdomen liquid, cerebrospinal fluid, after present system sample is loaded into sample unit, in system, complete full-automatic pretreatment process, eliminate the process of the manual pre-treatment of sample in conventional biochemical or immunodiagnosis process.
Described reagent strip is single index and/or multi objective reagent strip, wherein single index Dry-type biochemical reagent strip utilizes routine techniques means in industry, and single index immunochromatography reagent bar quotes the patent partial contents such as CN201420701947.0 full content and CN201410836485.8; Multi objective Dry-type biochemical mainly quotes the partial monopoly contents such as CN201310216838.X, CN200580018683.2, US7625721, and multi objective immunochromatography quotes the full content of CN201510147904.1.
Embodiment two:
As Fig. 1, 2, 3, 4, 5, 6, shown in 7, be applied to the device of system described in the present patent application, comprise multiple different preferred embodiment, wherein a kind of embodiment is biochemical immunity single reaction dish mixing arrangement, comprise support baseboard (1), sample unit (2), single reaction dish unit (3), application of sample unit (4), reagent strip stores and automatic loading unit (5), detecting unit (6) and circuit unit (7), another kind of embodiment is that the two reaction tray of biochemical immunity integrates parallel device, comprise unit mechanical arm and double mechanical arms two kinds of forms, comprise support baseboard (1 ' equally, 1 "), sample unit (2 ', 2 "), reaction tray unit (3 ', 3 "), application of sample unit (4 ', 4 "), reagent strip stores and automatic loading unit (5 ', 5 "), detecting unit (6 ', 6 ") and circuit unit (7 ', 7 ").In addition, the many modular constructions of unit such as the reaction tray unit in two kinds of embodiments, sample unit, application of sample unit are identical, and same section no longer distinguishes expression.
As shown in Figure 1, 2, 3, in the first embodiment,
Support baseboard (1) is to other unit supports of system and fix, and according to each unit distributing position on base plate, base plate is divided into former and later two regions, and wherein proparea is each unit assembling district, and back zone is circuit unit;
Sample unit (2) is positioned at the side in support baseboard (1) proparea, comprises sample area, consumptive material district and sample preparation district;
Reaction tray unit (3) is positioned at the opposite side in support baseboard (1) proparea, comprise reaction tray assembly (301) and stepper assemblies (302), wherein reaction tray assembly (301) is on support baseboard (1) top, stepper assemblies (302) is in support baseboard (1) bottom, and the two coaxially connects;
Application of sample unit (4) is positioned at sample unit (5) and reaction tray unit (3) top, comprises XYZ robot assemblies (401,402,403), disposable tip pick-up and sample-adding pump;
Reagent strip stores and loading unit (5) is surrounded on reaction tray unit (3) left-external side automatically, comprises bracket component (501), storage box assembly (502) and automatic charging assembly (503);
Detecting unit (6) is positioned at reagent strip and stores position between (5) and circuit unit (7), multiple different detection components can be carried, as the wheeled biochemistry detection that filters, colorimetric detection, fluoroscopic examination, raster pattern biochemistry detection, CCD detect, complete the optical detection of dry type immunity and Dry-type biochemical;
Circuit unit (7) is casing, is positioned at support baseboard (1) back zone, comprises power supply, multiple control element and treatment element, and each element electrical connection, control system is run.
As Fig. 4, shown in 5,6, in another kind of embodiment
Described support baseboard (1 ') plays support and fixation to other unit of system, according to each unit distributing position on base plate, base plate is divided into former and later two regions, and wherein proparea is each unit assembling district, and back zone is circuit unit;
Described sample unit (2 ') is positioned at the middle part in support baseboard proparea, comprises sample area, consumptive material district and sample preparation district;
Described reaction tray unit (3 ') comprises two reaction tray, distribute in sample unit both sides, a Dry-type biochemical reaction tray, an immunochromatography reaction tray, include reaction tray assembly (301) and stepper assemblies (302), wherein reaction tray assembly (301) is on support baseboard top, and stepper assemblies (302) is in support baseboard bottom, and the two coaxially connects;
Described application of sample unit (4 ') is positioned at sample unit (5 ') and reaction tray unit (3 ') top, comprises XYZ robot assemblies (401 ', 402 ', 403 '), disposable tip pick-up and sample-adding pump;
Described reagent strip stores and loading unit (5 ') comprises two same components automatically, one for Dry-type biochemical, one is surrounded on outside two reaction tray respectively for immunochromatography, includes bracket component (201), storage box assembly (202) and automatic charging assembly (203);
Described detecting unit (6 ') is positioned at reagent strip and stores and automatically load between circuit unit (5 '), Dry-type biochemical and immunochromatography respectively have one, wherein Dry-type biochemical detection components is positioned at below reaction tray, immunochromatography detection components is positioned at above reaction tray, the optical detection of corresponding immunochromatography and Dry-type biochemical reaction respectively;
Described circuit unit (7 ') is a casing, is positioned at support baseboard back zone, comprises power supply, multiple control element and treatment element, and each interelement electrical connection, controls the operational process of whole system.
Embodiment three:
As shown in Figure 10, described application of sample unit (4, 4 ', 4 " XYZ mechanical arm) is comprised, disposable tip pick-up and sample-adding pump, wherein X arm (401, 401 ') along circuit unit (7, 7 ') upper horizontal is placed, Y arm (402, 402 ') sample unit (5 is positioned at, 5 ', 5 ") above level, mutually vertical with X arm, slide along X arm, article one, Y arm is single armed system, article two, Y arm is dual arm system, Z arm (403, 403 ') be vertically fixed in the sliding tray of Y arm, can slide along Y arm, also can slide up and down in upright position, the first embodiment wherein in embodiment two is single armed system, the second embodiment can select single armed or dual arm system (as illustrated in figures 4 and 7), be preferably dual arm system, XYZ arm all establishes motor, for each arm motion provides power, described Z arm bottom connects disposable tip pick-up, and is connected with sample-adding pump, for application of sample provides power.
In another embodiment, as shown in Figure 7, the two reaction tray system of the present invention is single arm type system, during system cloud gray model, according to instruction XYZ mechanical arm 4 " respectively application of sample is carried out to reagent strip in two reaction tray.
As shown in Figure 8, described sample unit (2,2 ', 2 ") is drawer-like box body, and there is baffle plate the box body left and right sides, and pulley and slide rail are arranged at outside baffle plate or bottom, and box body slides on support baseboard, skid off and fix.
Described box body is divided into two parts in left and right, comprise disposable tip box (205), mixing box (206), dilution frame (202), specimen holder (201), suction nozzle recycling box (204), wherein specimen holder (201) and dilution frame (202) to be positioned on the right side of box body on base plate, base plate is provided with track, specimen holder (201) and dilution liquid bath (202) bottom arrange the draw-in groove supporting with track, and specimen holder (201) and dilution frame (202) are at the upper slide anteroposterior of floor rail (203); On the left of box body, platform is set, platform lower is every sky, suction nozzle recycling box (204), disposable tip box (205) and mixing box (206) are emitted on platform, the vertical part of suction nozzle recycling box (204) is on platform, partially pass through platform to go directly support baseboard, there is recovery port on top, bottom open-ended, and suction nozzle directly falls into support baseboard after entering recovery port.
Arrange according to sample unit parts as shown in Figure 8, the present patent application, by the pretreatment process of disposable tip, mixing box and the complete paired samples of dilution frame, eliminates hand sample pretreatment process, operation object full-automatic after achieving application of sample.
As shown in Figure 9, described reaction tray (3,3 '; 3 ") be discoid device, disk border comprises multiple reagent strip fixed bit (301), is preferably 16-20 slot, and slot mouth and reagent strip store and loading unit (5,5 ', 5 " reagent strip exit position) is corresponding; Reaction tray is rotated and reagent strips is completed application of sample operation to application of sample unit correspondence position; Reaction tray is rotated reagent strips is completed detection operation to the position that detection module is corresponding; Wherein Fig. 1,2,3 illustrated embodiments are single-deck device, for Dry-type biochemical and immunochromatography simultaneously used in combination; Fig. 4,5,6,7 illustrated embodiments are double plate device, Dry-type biochemical and immunochromatography use side by side at individual dish simultaneously, and reaction tray is rotated and driven, comprising stepper motor, synchronizing wheel, Timing Belt by stepper assemblies (302).
Described reaction tray comprises temperature control system, for providing temperature guarantee when Dry-type biochemical reaction is hatched.
As shown in Figure 11,12,13,14, described reagent strip stores and automatic loading unit (5,5 '; 5 ") comprising reagent strip storage box (502), bracket component (501) and automatic charging assembly (503), bracket component (501) is fixed on support baseboard; Reagent strip storage box (502) is fixed on bracket component (501) by padlock (505), storage box comprises box body (5022) and lid (5021) part, box body, lid seal, reagent strip decline guide rail (5026) is had in box, (5024, there is a sealing shell fragment (5023) side near this breach bottom a breach bottom box; Automatic charging assembly comprises motor, synchronizing wheel, Timing Belt and elasticity peg (not embodying in figure), control system controls motor rotation, drive the motion of synchronizing wheel, Timing Belt, elasticity peg, reagent strip is gone out from storage box bottom hook, send in reaction tray reagent strip slot; In the storage box that wherein each reaction tray region is corresponding and automatically loading unit, storage box quantity is 1-3, is preferably 3, once completes 3 reagent strips and loads; In two kinds of forms, the corresponding reagent strip of each reaction tray stores and automatic loading unit;
As shown in figure 11, described storage box assembly has reagent strip information identification reading assembly (504), comprise sensor and signal transmission unit, identification agent bar kind of information also transfers to control element, read and identify reagent strip kind signal in storage box and be transferred to control assembly, send instruction, complete subsequent operation according to this instruction.
As shown in Figure 15,16, described detecting unit (6,6 '; 6 ") comprise immunochromatography and Dry-type biochemical detection components, wherein immunochromatography detection components is positioned at above reaction tray, and light irradiates reagent strip end face from top to bottom, and described reagent strip detect aperture is positioned at reagent strip end face; Dry-type biochemical detection components is positioned at below reaction tray, light irradiates reagent strip bottom surface from bottom to top, and described reagent strip detect aperture is positioned at reagent strip bottom surface, in form one, respectively there is a detection components the upper and lower relevant position of reaction tray, is respectively above-mentioned immunochromatography and Dry-type biochemical detection components; In form two, the corresponding corresponding detection components of each reaction tray, Dry-type biochemical reaction tray detecting unit position is Dry-type biochemical detection components, and immunochromatography reaction tray detecting unit position is immunochromatography detection components.
If the present invention detects for the Dry-type biochemical of single index or immunochromatography reagent bar, its detecting unit is conventional openly detection means, does not repeat them here.If the Dry-type biochemical of multi objective or immunochromatography reagent bar, then utilize detecting unit as described below.
As shown in figure 16, described multicolor fluorescence immunochromatography detection components comprises excitation light path, fluorescence light path and photo-translating system, wherein excitation light path comprises light source (606), collimating mirror (607), condenser lens (608) and slit (609), light source is launched exciting light and is collimated through collimating mirror, line focus lens focus, again through slit, form size to fit hot spot, 45 ° of incident angles expose to surveyed area (610), emitting fluorescence after test substance is excited, if this reagent strip district to be measured only a kind of index, then this fluorescence is only a kind of, directly focus on photoelectric cell through double lens, testing concentration is calculated again through photo-translating system, if this reagent strip is multicolor fluorescence reagent strip, then this fluorescence is multiple mixing, fluorescence is separated into each Single wavelength fluorescence through two-phase dichronic mirror (613,617,618) again and is collected by photoelectric cell after double lens (611,612), then calculates each testing concentration through photo-translating system (614,615,616).
As shown in figure 15, described Dry-type biochemical detection components comprises input path, reflected light path and photo-translating system, wherein input path comprises light source (601), condenser lens (602), filter wheel (603), reflected light path comprises photoelectric cell, some formula biochemical reagents bars only a kind of index to be measured, then filter wheel (603) is Single wavelength optical filter corresponding to this index, through light source (601), condenser lens (602), optical filter (603), Single wavelength illumination is incident upon reagent strip back reflection light and enters photoelectric cell (604), single index concentration is calculated through photo-translating system, some formula biochemical reagents bars are multi objective reagent strip, be preferably 8-12 index, then filter wheel (603) there is the Single wavelength optical filter corresponding one by one with reagent strip (605) multiple index substance, during detection, light source (601) is luminous, line focus lens (602), filter wheel (603) rotates, in short time, filter wheel (603) the Single wavelength light completed needed for multiple index to be measured is radiated at each detect aperture back reflection of reagent strip bottom surface, and photoelectric cell (604) calculates the concentration of multi objective again through converting system after receiving reflected light signal.
Described circuit unit is positioned at base plate back zone, comprises case lid, front boxboard, rearing-box plate and side box plate, wherein, boxboard is arranged and washes needle tray, for sample adding device cleaning, have conduit to be connected with the bottle for handling liquid toilet or cosmetic substance outside case, waste liquid bottle in groove.
Analytic system outside comprises housing, and housing front portion is provided with touching type operation platform.
Claims (19)
1. a biochemical immunity hybrid analysis system, comprises Dry-type biochemical and immune system, it is characterized in that Dry-type biochemical and immune system are incorporated into a system, simultaneously or analyze separately, completes sample variation and detects.
2. system according to claim 1, is characterized in that analysis type comprises whole Dry-type biochemical and immunoassay type, preferred dry biochemistry, micro-current control biochemical, fluorescence immunoassay, micro-fluidic immunity, colloid gold immune, the immunity of colored latex.
3. system according to claim 1, is characterized in that analysis comprises single index reagent analysis and multi objective associating reagent analysis.
4. system according to claim 1, is characterized in that described Dry-type biochemical and dry type immunity is module integrated runs in a new commingled system.
5. system according to claim 1, is characterized in that described Dry-type biochemical and dry type immunity module side by side, the isolated operation in same system of two modules.
6. the system according to claim 4 or 5, is characterized in that described module includes reagent strip and stores and loading unit, reaction tray unit, sample unit, application of sample unit, detecting unit and circuit control unit.
7. system according to claim 4, it is characterized in that new commingled system stores biochemical and/or immunoreagent bar, after system cloud gray model, reagent strip is loaded on reaction tray unit, after application of sample unit inhales sample, process, application of sample is in reagent strip, in reaction tray, complete reaction, enter detecting unit and complete detection, draw testing concentration.
8. system according to claim 5, it is characterized in that coordinate system stores biochemical and immunoreagent bar separately, after system cloud gray model, reagent strip is loaded on reaction tray unit, after application of sample unit inhales sample, process, application of sample is in reagent strip, in reaction tray, complete reaction, enter each module of detecting unit and complete detection, draw testing concentration.
9. the system according to claim 7 or 8, it is characterized in that described detection comprises colorimetric determination, CCD detects and fluoroscopic examination, wherein fluoroscopic examination object comprises fluorescence immunoassay and micro-fluidic immunity; Colorimetric determination or CCD detected object comprise the immunity of Dry-type biochemical, micro-current control biochemical, colloid gold immune and colored latex.
10. system according to claim 1, is characterized in that detecting sample type comprises whole blood, serum, blood plasma, urine, saliva, abdomen liquid, cerebrospinal fluid, completes full-automatic pre-treatment operation, does not need pre-treatment before loading after described sample loading system.
The device of 11. 1 kinds of systems as claimed in claim 1, comprise single reaction dish and two reaction tray two kinds of forms, include support baseboard, reagent strip stores and loading unit, reaction tray unit, sample unit, application of sample unit, detecting unit and circuit control unit: in single reaction dish device:
1) support baseboard is to system support with fixing, and according to each unit position distribution on base plate, base plate is divided into former and later two regions;
2) sample unit is positioned at side, base plate proparea, comprises sample area, consumptive material district and treatment region;
3) reaction tray unit is positioned at base plate proparea opposite side, comprises rotating disk and electric machine assembly;
4) application of sample unit is positioned at above sample and reaction tray unit, comprises robot assemblies, suction nozzle pick-up and sample-adding pump;
5) reagent strip storage and loading unit are surrounded on outside reaction tray unit, and comprise bracket component, storage box assembly and charging assembly, storage box is fixed in bracket component, and charging assembly is positioned at below support and storage box;
6) detecting unit is positioned at reagent strip storage and loading unit side, comprises light source, lens class component and signal receiving device, completes biochemical and immunoreactive detection;
7) circuit control unit comprises power supply, control and treatment element, and each element electrical connection, control system is run.
In two reaction tray device:
1) support baseboard is to system support with fixing, according to each unit position distribution on base plate, base plate is divided into former and later two regions;
2) sample unit is positioned at base plate proparea central authorities, comprises sample area, consumptive material district and treatment region;
3) reaction tray unit two reaction tray is positioned at the sample unit left and right sides, comprises rotating disk and electric machine assembly;
4) application of sample unit is positioned at above sample and reaction tray unit, comprises mechanical arm, suction nozzle pick-up and sample-adding pump;
5) reagent strip storage and loading unit are surrounded on outside reaction tray unit, and comprise bracket component, storage box assembly and charging assembly, storage box is fixed in bracket component, and charging assembly is positioned at below support and storage box;
6) detecting unit is positioned at reagent strip storage and loading unit side, comprises light source, lens class component and signal receiving device, completes biochemical and immunoreactive detection;
7) circuit control unit comprises power supply, control and treatment element, and each element electrical connection, control system is run.
12. devices according to claim 11, it is characterized in that described sample unit is box body, support baseboard slides into, skid off and fixes, box plate is arranged successively removable sample cell, dilution liquid bath, disposable tip box, mixing box and suction nozzle recycling box.
13. devices according to claim 11, it is characterized in that described reaction tray unit rotary disc assembly is discoid, edge has multiple reagent strip fixed bit, with dial rotation, completes the process of its carrying reagent strip application of sample, detection.
14. devices according to claim 11, it is characterized in that described application of sample unit comprises XYZ mechanical arm, suction nozzle pick-up and sample-adding pump, in XYZ mechanical arm, X arm is positioned at circuit control unit top, Y arm horizontal vertical is in X arm, and slide along X arm, Z arm is vertically perpendicular to Y arm, slide along Y arm, move up and down, Z arm bottom connects suction nozzle pick-up, connects sample-adding pump simultaneously simultaneously; XYZ mechanical arm also optional a kind of both arms form in described pair of reaction tray device, X arm has two Y arms slide, completes the application of sample to independent reaction tray separately.
15. devices according to claim 11, it is characterized in that described reagent strip stores and loading unit comprises bracket component, storage box assembly and charging assembly, bracket component is surrounded on outside reaction tray unit, storage box assembly is removably placed on bracket component, charging assembly is positioned at bottom support and storage box, comprise motor and hook, link up with and reagent strip is hooked reaction tray reagent strip fixed bit from storage box.
16. devices according to claim 15, it is characterized in that described storage box assembly is sealing box body, multiple reagent strip is sequentially stacked in box, bottom box body, there is opening side, reagent strip is hooked reaction tray reagent strip fixed bit by opening by elastic hook, opening sets back, and keeps the sealing of box body; Described storage box assembly has reagent strip information identification reading assembly, comprises sensor and signal transmission unit, and identification agent bar kind of information also transfers to control element.
17. devices according to claim 11, it is characterized in that described detecting unit is in reagent strip storage and between loading unit and circuit control unit, detecting pattern can select colorimetric determination or CCD to detect or one or more in immune detection, and wherein immune detection object comprises fluorescence immunoassay and micro-fluidic immunity; Colorimetric determination or CCD detected object comprise Dry-type biochemical analysis, micro-current control biochemical analysis, colloid gold immune and the immunity of colored latex.
18. devices according to claim 17, it is characterized in that described colorimetric determination light path comprises light source, lens, optical filter or filter wheel or grating, detection zone and photo-translating system, during detection, light source luminescent is through lens, optical filter or filter wheel or grating expose to surveyed area, be photoelectrically converted after reflection systematic collection, draw index concentration as calculated, wherein, single index detection employing optical filter leaches the Single wavelength incident light needed for index, multi objective associating reagent strip detection employing filter wheel or grating leach the multiple Single wavelength incident lights needed for multiple index, the Single wavelength optical filter that on described filter wheel, evenly distributed multiple index to be measured is corresponding.
19. devices according to claim 17, it is characterized in that described fluorescence immunoassay detects light path and comprises excitation source, lens, detection zone, lens, photo-translating system, during detection, light source is launched exciting light and is exposed to detection zone through lens, slit, fluorescent material excitation-emission fluorescence, be photoelectrically converted systematic collection after lens, calculates index concentration to be measured; Wherein, when carrying out single index and detecting, above-mentioned light path is adopted; When carrying out multi objective joint-detection, fluorescence separates through two-phase dichronic mirror the systematic collection that to be photoelectrically converted after each Single wavelength light again after lens, calculates the concentration of multi objective.
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|---|---|---|---|---|
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090117660A1 (en) * | 2005-04-30 | 2009-05-07 | Oakville Hong Kong Co., Limited | Devices and methods for sample collection and analysis |
| CN201958876U (en) * | 2011-01-25 | 2011-09-07 | 赵杰修 | Athletic-training mobile monitoring equipment in high-temperature environment |
| CN202024960U (en) * | 2011-03-30 | 2011-11-02 | 深圳市康立高科技有限公司 | Optical system for flowing type semi-automatic biochemical analyzer |
| CN202404012U (en) * | 2011-12-28 | 2012-08-29 | 上海丰汇医学科技有限公司 | Optical system of spectrophotometer for biochemical analyzer |
| CN103105359A (en) * | 2012-12-21 | 2013-05-15 | 深圳市锦瑞电子有限公司 | Optical system of biochemical analyzer and biochemical analyzer |
| CN204347046U (en) * | 2014-12-29 | 2015-05-20 | 基蛋生物科技股份有限公司 | A kind of full-automatic fluorescence immunoassay quantitative analysis device |
-
2015
- 2015-08-03 CN CN201510467986.8A patent/CN105181591A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090117660A1 (en) * | 2005-04-30 | 2009-05-07 | Oakville Hong Kong Co., Limited | Devices and methods for sample collection and analysis |
| CN201958876U (en) * | 2011-01-25 | 2011-09-07 | 赵杰修 | Athletic-training mobile monitoring equipment in high-temperature environment |
| CN202024960U (en) * | 2011-03-30 | 2011-11-02 | 深圳市康立高科技有限公司 | Optical system for flowing type semi-automatic biochemical analyzer |
| CN202404012U (en) * | 2011-12-28 | 2012-08-29 | 上海丰汇医学科技有限公司 | Optical system of spectrophotometer for biochemical analyzer |
| CN103105359A (en) * | 2012-12-21 | 2013-05-15 | 深圳市锦瑞电子有限公司 | Optical system of biochemical analyzer and biochemical analyzer |
| CN204347046U (en) * | 2014-12-29 | 2015-05-20 | 基蛋生物科技股份有限公司 | A kind of full-automatic fluorescence immunoassay quantitative analysis device |
Cited By (26)
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| CN106405131A (en) * | 2016-08-24 | 2017-02-15 | 冯晓均 | Cell and protein combined analysis device and combined analysis method |
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