CN107271701A - A kind of multi-purpose medical detector and detecting system - Google Patents
A kind of multi-purpose medical detector and detecting system Download PDFInfo
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- CN107271701A CN107271701A CN201610218215.XA CN201610218215A CN107271701A CN 107271701 A CN107271701 A CN 107271701A CN 201610218215 A CN201610218215 A CN 201610218215A CN 107271701 A CN107271701 A CN 107271701A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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Abstract
The invention discloses a kind of multi-purpose medical detector and detecting system, detector includes sample charging mechanism, drive mechanism, reaction warehouse, image capture module and testing result processing module；Reagent disc of the reaction warehouse for any one or more project in placement detection Blood coagulation test, Blood grouping and immune detection, reaction warehouse keeps being incubated the temperature of environment；Output shaft is driven to be located in the middle part of reaction warehouse, for driving the reagent disc spins in reaction warehouse；Sample charging mechanism is used to be sample-adding in each well of reagent disc；Wherein image capture module follows the rotation of reagent disc, and the view data of at least one reagent trough or interpretation window on reagent disc is gathered successively；Testing result processing module, the view data for being gathered according to image capture module analyze obtaining testing result.Detector multipurpose provided in an embodiment of the present invention is integrated, and compact can be minimized, is easy to carry, and simple to operate, application field is wide.
Description
Technical field
The present invention relates to a kind of multi-purpose medical detector and detecting system.
Background technology
At present, medical treatment detection device is essential in medical domain, and the effect of performance is increasing, is led to
Tested, controlled device healthy situation can be obtained in time by crossing detection, and auxiliary doctor judges the state of an illness.With
The extensive use of computer technology, there is many Medical Devices detectors, such as Blood coagulation test on the market now
Instrument, blood type analytical instrument, immunity analysis instrument etc..
But above-mentioned detection device is on the one hand:A kind of methodology detection is only used for, purposes is relatively simple, if
The detection of multiple projects is completed, such as：Blood clotting, blood group and immune detection etc., because detection method is different,
Generally require to be respectively completed detection by many distinct devices；On the other hand adopted in existing assay device structures
Driven with motor, belt transmission etc., overall volume is larger；And complex operation, can only be by professional inspection teacher
Operate and carried out in the laboratory of specialty, it is time-consuming longer from the point of view of sampling, sample presentation and detection process, for
Interrogation in patient home is gone in some occasions higher to detecting ageing requirement, such as first aid, family general practitioner
It can not be applicable etc. occasion etc..How to design a kind of multipurpose, small volume be convenient for carrying, inspection simple to operate
Instrument is surveyed, is urgent problem to be solved.
The content of the invention
In view of the above problems, the embodiment of the present invention provides and overcomes above mentioned problem or solve at least in part above-mentioned
A kind of multi-purpose medical detector and detecting system of problem.
As the one side of the embodiment of the present invention, it is related to a kind of multi-purpose medical detector, including：Plus
Model machine structure, drive mechanism, reaction warehouse, image capture module and testing result processing module；The reaction warehouse
For the reagent disc of any one or more project in placement detection Blood coagulation test, Blood grouping and immune detection, institute
Reaction warehouse bottom is stated provided with heater block；The drive mechanism has driving output shaft, the driving output shaft
In the middle part of the reaction warehouse, for driving the reagent disc spins in reaction warehouse；The sample charging mechanism is used for
It is loaded in each well of reagent disc；Described image acquisition module is located at the top of the reaction warehouse, is used for
The rotation of reagent disc is followed, the picture number of at least one reagent trough or interpretation window on reagent disc is gathered successively
According to；The testing result processing module, the view data for being gathered according to described image acquisition module is carried out
Analysis obtains testing result.
Alternatively, the drive mechanism includes being arranged on the motor of reaction warehouse bottom, the driving electricity
The output shaft of machine is connected with external tooth gear, and the external tooth gear is placed in the middle part of reaction warehouse, for by with examination
Internal tooth engaged transmission in agent disk drives the reagent disc spins；In the reaction warehouse it is circumferentially arranged have to
Few three spacing guide wheels, the position for determining reagent disc in the reagent disc spins time limit.
Alternatively, the drive mechanism includes being arranged on the motor of reaction warehouse bottom, the reagent disc
Rotated coaxially between the output shaft of motor.
Alternatively, the sample charging mechanism includes：Transmission mechanism and the sample-adding being connected with the transmission mechanism
Head.
Alternatively, the feed head includes：For pick up disposable tip syringe and with the note
Pressure sensor, sample-adding pump and the controller of emitter connection；The pressure sensor is used to detect the note
Air pressure in emitter；The sample-adding pump is used to provide power when being loaded to reagent disc for syringe；The control
Device is used for the air pressure detected according to the pressure sensor, is compared with default voltage threshold, controls
Make the air pressure in the syringe and reach air pressure needed for current injector working condition；The working condition
Including：Suction status, liquid relief state and sample-adding state.
Alternatively, the controller is additionally operable to during the syringe pickup disposable tip of feed head,
Air pressure in syringe is detected by the pressure sensor, determines whether disposable tip is damaged or stifled
Plug.
Alternatively, the controller is additionally operable to during the syringe pickup disposable tip of feed head,
The change of the air pressure in syringe is detected by the pressure sensor, determines to whether there is bubble in sample
Or grumeleuse.
Alternatively, the transmission mechanism includes：X-axis movement arm, Y-axis movement arm and Z axis movement arm；X
Axle, Y-axis and Z axis are the reference axis in rectangular coordinate system in space；X-axis movement arm and Y-axis movement arm difference
It is connected with the two ends of Z axis movement arm；Be provided with each movement arm motor, connect the screw mandrel of motor with
And the sliding shoe on screw mandrel is enclosed on, rotated by motor drive screw, drive sliding shoe to slide；It is described to add
Sample head is fixed on the sliding shoe of that higher movement arm of position in both X-axis movement arm and Y-axis movement arm
On.
Alternatively, the heater block of the reaction warehouse is the heating film for being covered in reaction warehouse bottom, described to add
Hotting mask enables to temperature stabilization in reaction warehouse to control in preset temperature.
Alternatively, the detector is additionally provided with waste holder, the waste holder open top, the opening
Place is provided with least two panels shell fragment, for blocking the disposable tip on feed head so that feed head and described one
Secondary property suction nozzle separation.
Alternatively, the detector also includes being placed with disposable tip in suction nozzle box, the suction nozzle box.
Alternatively, the testing result processing module gathers mould by wired or wireless receiving described image
The view data of block collection.
On the other hand, the embodiment of the present invention additionally provides a kind of multi-purpose medical detecting system, including reagent
Disk and above-mentioned detector provided in an embodiment of the present invention；The reagent disc is in annular, including at least one
Reactive tank；At least one described reactive tank is one of the following or any combination：Comprising well, magnetic bead and
The reactive tank of Blood coagulation test reagent；Reactive tank comprising well and Blood grouping reagent；Comprising well,
The reactive tank of interpretation window and immunologic function test reagent.
The embodiment of the present invention at least realizes following technique effect：
In above-mentioned multi-purpose medical detector provided in an embodiment of the present invention and multi-purpose medical detecting system,
Detector includes sample charging mechanism, drive mechanism, reaction warehouse, image capture module and testing result processing mould
Block；Reaction warehouse is for any one or more project in placement detection Blood coagulation test, Blood grouping and immune detection
Reagent disc, reaction warehouse keeps being incubated the temperature of environment；Output shaft is driven to be located in the middle part of reaction warehouse, for driving
Reagent disc spins in reaction warehouse；Sample charging mechanism is used to be sample-adding in each well of reagent disc；Wherein image is adopted
Collection module follows the rotation of reagent disc, and at least one reagent trough on reagent disc or interpretation window are gathered successively
View data；Testing result processing module, the view data for being gathered according to image capture module is divided
Analysis obtains testing result.Detector multipurpose provided in an embodiment of the present invention is integrated, and compact can
To minimize, it is easy to carry, so as to shorten the time expended from sampling, sample presentation and detection whole process, behaviour
Make simple, application field is wide, it is possible to achieve detection, family general practitioner are suffering from by the sick bed of clinical department
Detected in person family, the higher occasion of degree of being pressed for time requirement such as emergency first-aid.
Other features and advantages of the present invention will be illustrated in the following description, also, partly from explanation
Become apparent, or understood by implementing the present invention in book.Objectives and other advantages of the present invention can
Realize and obtain by specifically noted structure in the specification, claims and accompanying drawing write
.
Below by drawings and examples, technical scheme is described in further detail.
Brief description of the drawings
Accompanying drawing is used for providing a further understanding of the present invention, and constitutes a part for specification, with this hair
Bright embodiment is used to explain the present invention together, is not construed as limiting the invention.In the accompanying drawings：
Figure 1A is the dimensional structure diagram of detector provided in an embodiment of the present invention；
Figure 1B is the side structure schematic diagram of detector provided in an embodiment of the present invention；
Fig. 1 C are the shell schematic diagram of detector provided in an embodiment of the present invention；
Fig. 2 is the structural representation of motor eccentric drive reagent disc provided in an embodiment of the present invention；
Fig. 3 is feed head structural representation provided in an embodiment of the present invention；
Fig. 4 is the structural representation that tablet personal computer provided in an embodiment of the present invention connects multiple detectors；
Fig. 5 connects main control module for each module in detector provided in an embodiment of the present invention by CAN
Schematic diagram；
The structural representation of hemagglutination groove in the reagent disc that Fig. 6 provides for detecting system of the embodiment of the present invention；
The structural representation of blood group reactive tank in the reagent disc that Fig. 7 provides for detecting system of the embodiment of the present invention；
The structural representation of immune response groove in the reagent disc that Fig. 8 provides for detecting system of the embodiment of the present invention.
Embodiment
The exemplary embodiment of the disclosure is more fully described below with reference to accompanying drawings.Although being shown in accompanying drawing
The exemplary embodiment of the disclosure, it being understood, however, that may be realized in various forms the disclosure without should be by
Embodiments set forth here is limited.It is opposite to be able to be best understood from this there is provided these embodiments
It is open, and can by the scope of the present disclosure completely convey to those skilled in the art.
In order to solve the problem of existing detecting instrument is present, reference picture 1A, 1B, 1C and Fig. 2, the present invention
Embodiment provide a kind of multi-purpose medical detector, the detector include sample charging mechanism 1, drive mechanism 2,
Reaction warehouse 3, image capture module 4 and testing result processing module (not illustrated in figure)；Wherein：Reaction
Reagent disc of the storehouse 3 for any one or more project in placement detection Blood coagulation test, Blood grouping and immune detection
5, and the bottom of reaction warehouse 3 is provided with heater block, temperature needed for simulation and guarantee experimental situation；Driving machine
The driving output shaft 21 of structure 2, positioned at the middle part of reaction warehouse 3, for driving the reagent disc 5 in reaction warehouse 3
Rotation, minimizes detector volume；Sample charging mechanism 1 can be accurately sample-adding in each well of reagent disc 5；
Image capture module 4 in detection process, the rotation for following reagent disc 5 gathers reagent disc 5 successively
On at least one reagent trough or interpretation window view data；And the view data collected, send
To testing result processing module analyze obtaining testing result.
An equipment is realized in this specific embodiment can realize the function of multipurpose detection；The present embodiment
The detector of offer is used for the analytical instrument that hospital and family are detected, coordinates different detection reagent disks 5 can be with
Clinical immunology is carried out, post aggegation bracket for blood grouping, cross matching, blood coagulation time is detected, is more than one
The compact apparatus of unification.
Shown in reference picture 1A, Fig. 2, wherein reaction warehouse 3 is used to place detection Blood coagulation test, Blood grouping
With the reagent disc 5 of any one or more project in immune detection, blood clotting, blood group can be detected simultaneously and is immunized,
Projects combo it can also detect two-by-two；
Reagent wherein used is for example：
Blood coagulation：New treasured fibrin ferment freeze-dried powder, Chinese medicines quasi-word H32020892, Suzhou Xin Bao pharmaceutical Co. Ltds
Production；
Blood group：Abo blood group styling agent, Chinese medicines quasi-word S10950002, Chengdu consonance biotechnology is limited
Responsible company produces；
It is immune：Influenza B virus detection kit (colloidal gold method), Chinese medicines quasi-word S20063135, north
Jing Asi can carry out biological Engineering Co., Ltd's production；
Mentioned reagent is not limited only to the product of three above producer, other existing examinations for possessing above-mentioned functions
Agent also may be used.
Further, the bottom of reaction warehouse 3 is provided with heater block, and the heater block is to be covered in the bottom of reaction warehouse 3
The heating film in portion, the heating film make it that temperature stabilization control is in preset temperature in reaction warehouse 3, simulation human body
Isoperibol, employ PID (PID) regulation, can reach stability contorting temperature 37 DEG C ±
In the range of 0.1 DEG C.
Shown in reference picture 1A, Figure 1B, above-mentioned drive mechanism 2 has driving output shaft 21, driving output
Axle 21 is located at the middle part of reaction warehouse 3, for driving the reagent disc 5 in reaction warehouse 3 to rotate, and drives output shaft
21 position is set, and can be made the detector compact, is easy to carry, so as to realize the disease in clinical department
The other detection of bed, family general practitioner detect that degree of the being pressed for time requirement such as emergency first-aid is higher in patient family
Occasion.
Further, in embodiments of the present invention, drive mechanism 2 can use motor 22, reference picture
Shown in 1A, reference picture 1B, the bottom of reaction warehouse 3 is arranged on, the output shaft 21 of the motor 22 is connected
There is external tooth gear, and have internal-gear in reagent disc 5, so by the engagement of external tooth and internal tooth, realize and drive
Dynamic motor 22 drives the rotation of reagent disc 5；And it is circumferentially arranged in reaction warehouse 3 to have at least three limits
Position guide wheel 6, the guide wheel can also be rotated, and when quantity is three, three spacing positions of guide wheel 6 can be protected
Card reagent disc 5 does not shift when rotating.The output shaft 21 of motor 22 is eccentrically set on instead
When answering in storehouse 3, shown in reference picture 2, external tooth is engaged with inner toothed portion, realizes the rotation of reagent disc 5, when
Reagent disc 5 is offset in the running, touches spacing guide wheel 6, and the setting of spacing guide wheel 6 controls reagent
The skew of disk 5, defines the position of reagent disc 5；There is skew and touches spacing guide wheel 6 in reagent disc 5
During so that spacing guide wheel 6 rotates, and so also reduces the contact friction of reagent disc 5 and spacing guide wheel 6
Power, it is ensured that the normal rotation of reagent disc 5.
Further, in embodiments of the present invention, when reagent disc 5 and motor 22 output shaft 21 it
Between rotate coaxially, that is, external tooth is at a fully engaged with internal tooth, realize concentric operate；Wherein motor 22
Direct driving motor can be used, key benefit is omitted the drive apparatus such as driving belt, and these drive disk assemblies are proper
Just it is the higher part of fault rate in system, it is ensured that the skew very little of reagent disc 5, reduces equipment fault
Rate.Technically, it may have lower fault rate.
Further, in embodiments of the present invention, sample charging mechanism 1 is used to be each well 52 of reagent disc 5
Middle sample-adding；Above-mentioned sample charging mechanism 1 includes transmission mechanism 11 and the feed head 12 being connected with transmission mechanism 11；
Wherein feed head 12 includes：For the pressure for picking up the syringe of disposable tip and being connected with syringe
Sensor, sample-adding pump and controller；Due to draw sample and be added dropwise sample during, syringe storehouse
Interior atmospheric pressure is different, so by monitoring the air pressure level in syringe storehouse in real time, control
Device controls sample-adding pump, and sample-adding pump controls the motion of syringe, and control is precisely loaded.
Shown in reference picture 3, air pressure is converted to voltage output by pressure sensor, and voltage is by signal condition electricity
Lu Hou, data signal is converted analog signals into by D/A conversion unit, becomes what controller can be read
Magnitude of voltage.Controller reads the voltage in real time, by being compared with default voltage threshold, control note
Air pressure in emitter reaches the air pressure needed for current injector working condition；Wherein sample-adding pump adds for syringe
Power is provided during sample, the working condition of syringe includes：Suction status, liquid relief state and sample-adding state.
Correspondingly, controller noted above is additionally operable to pick up disposable tip process in the syringe of feed head 12
In, the air pressure in syringe is detected by pressure sensor, compared with default atmospheric pressure value；If injection
Air pressure is excessive in device, it is determined that disposable tip is blocked；And if air pressure is too small in syringe, it is determined that
Disposable tip is damaged.
Correspondingly, controller noted above is additionally operable to pick up disposable tip process in the syringe of feed head 12
In, the change of the air pressure in syringe is detected by pressure sensor, determines to whether there is bubble in sample
Or grumeleuse, if it find that problem experiment can be terminated and alarmed.
Further, in embodiments of the present invention, shown in reference picture 1C, the IMAQ mould on detector
Block 4 is located at the top of reaction warehouse 3, and the rotation for following reagent disc 5 is gathered on reagent disc 5 successively
The view data of at least one reagent trough or interpretation window 54；Wherein image capture module 4 is arranged at reaction
All may be used any position that the top in storehouse 3 clearly can accurately shoot reagent disc.Whole doctor can be for example installed on
The top cover for treating the housing of detector is first-class, and the embodiment of the present invention is not limited this.
Testing result processing module, the view data for being gathered according to image capture module 4 analyze
To testing result.The embodiment of the present invention in specific implementation process, the testing result processing module can be with
Another equipment such as host computer that the detector becomes one or is provided separately, on this
Detector operation sequence is pre-installed in the machine of position, host computer is such as：The intelligence such as computer, tablet personal computer or mobile phone
Terminal.
Shown in reference picture 4, using such as bluetooth, WIFI, 3G (being not limited to above-mentioned communication)
Or USB data line and the structure of tablet personal computer networking, host computer uses tablet personal computer, and tablet personal computer is
Guest operation end, has pre-installed the operating system of analyzer, and wirelessly or non-wirelessly mode is connected with detector, receives
The view data that image capture module 4 is gathered, and carry out analysis meter calculation, it is possible to achieve a tablet personal computer connects
The effect of many detectors is connect, to improve efficiency.
Correspondingly, the detector can also include bar code scanner, be arranged on the top of reaction warehouse 3, be used for
The Quick Response Code on reagent disc 5 is scanned, the information such as the composition lot number and the term of validity of reagent disc 5 are determined.
Correspondingly, the detector can also include main control module, shown in reference picture 5, there is plant-grid connection, its
Middle main control module be provided with display screen and button, main control module by CAN (controller local area network,
Controller Area Network, abbreviation CAN) bus connection sample charging mechanism 1, image capture module 4, drive
Motivation structure 2, reaction warehouse 3, bar code scanner, and instruction control said apparatus can be sent according to detection
Flow normal work, and receive said apparatus feedack；Wherein main control module with host computer by having
Line or radio communication, send the data detected to host computer and analyze obtaining testing result.
Further, in embodiments of the present invention, shown in reference picture 1A, Fig. 2, above-mentioned transmission mechanism 11
Including：X-axis movement arm, Y-axis movement arm and Z axis movement arm；X-axis, Y-axis and Z axis are space right-angle
Reference axis in coordinate system；The two ends of X-axis movement arm and Y-axis movement arm respectively with Z axis movement arm are connected；
Motor, the sliding shoe for connecting the screw mandrel of motor and being enclosed on screw mandrel are provided with each movement arm, is led to
The rotation of motor drive screw is crossed, drives sliding shoe to slide；The feed head 12 be fixed on X-axis movement arm and
In both Y-axis movement arms on the sliding shoe of that higher movement arm of position.X-axis movement arm, Y-axis motion
Arm and Z axis movement arm, cooperate motion；Three stepper motors drive leading screw to rotate, so as to drive cunning
Motion block is slided, and is realized the position movement of three reference axis, is moved on accurate direction and position, is loaded
First 12 are responsible for sampling and dropping liquid.
Further, above-mentioned detector can also include being placed with disposable suction in suction nozzle box 8, suction nozzle box 8
Head.In a particular embodiment, suction nozzle box 8 are arranged on the side of detector, for holding disposable tip.
Further, above-mentioned detector is also provided with waste holder 7, the open top of waste holder 7, opening
Place is provided with least two panels shell fragment, for blocking the disposable tip on feed head 12 so that feed head 12 and one
Secondary property suction nozzle separation., it is necessary to disposable tip be discarded, in master control after the sample-adding for completing sample terminates
Under the instruction of module, realize that automation abandons disposable tip, without manual hand manipulation；Control transmission
Structure movement makes feed head 12 be moved to the top of waste holder 7, disposable tip is extend into waste holder 7 and opens
It is intraoral, the shell fragment high resilience at the opening of waste holder 7, and disposable tip is blocked, it is upward in drive mechanism
During lifting so that feed head 12 is separated with disposable tip, disposable tip falls into waste holder 7
In.
The embodiment of the present invention additionally provides a kind of multi-purpose medical detecting system, and the detecting system includes this hair
Above-mentioned detector and reagent disc 5 that bright embodiment is provided；The reagent disc 5 is in annular, including at least one
Reactive tank 51, wherein 51 points of reactive tank are three kinds：
The first：Reference picture 6, the reactive tank 51 comprising well 52, magnetic bead 53 and Blood coagulation test reagent,
For detecting blood clotting time；
Second：Reference picture 7, the reactive tank 51 comprising well 52 and Blood grouping reagent, for examining
Survey blood group；
The third：Reference picture 8, includes the reactive tank of well 52, interpretation window 54 and immunologic function test reagent
51, for immune detection.
Correspondingly, the reactive tank 51 in the embodiment of the present invention on mentioned reagent disk 5 can be above-mentioned three kinds it
One or any combination, that is to say, that in the reagent disc 5, can comprising be only used for blood clotting, blood group or
The reactive tank 51 of any of immune detection, the reactive tank of two or more detection project can also be included simultaneously
51.Can many people with item detect or with the detection of people's different item.
Detector is additionally provided with shell in itself in the present embodiment, shown in reference picture 1C, to above-mentioned modules
Play a protective role, shell is opened after hatch door provided with that can open the hatch door of closure, can place examination
Agent disk 5.
The course of work to three detection projects of the specific embodiment of the invention is described in detail below：
First, blood clotting project：
1. experiment prepares：Blood clotting project reagent disc packing box is taken out, appropriate time is placed and returns to room temperature
Afterwards, packing box is opened, reagent disc is taken out, detector hatch door is opened, reagent disc is loaded into reaction warehouse.Take
Detection blood sample, is put into detector Riker mount；
In blood clotting reagent disc, structure reference picture 6, each reagent disc well and magnetic bead are integrated with comprising several
Reactive tank, several Blood coagulation test projects can be measured simultaneously.
2. on host computer, such as compiling and edit test procedure on tablet personal computer, selection is corresponding to be tested, and defeated
Enter the essential information of detected personnel.Confirmation equipment state is clicked on after can testing starts experiment.Instrument meeting
Detected automatically according to setting item.
3. pick up suction nozzle：Detector operates sample charging mechanism, and mobile feed head picks up suction nozzle to suction nozzle box position,
And detect whether suction nozzle is normal by pressure detection module, judge suction nozzle with the presence or absence of blocking and gas leakage；Such as
It is problematic to send alarm, remind human intervention to reappose new disposable tip；Such as have no problem, so
After be moved at Riker mount absorption sample, during drawing sample, feed head can be according to the change of pressure
Detect and whether there is bubble in sample, the material of the influence detection such as grumeleuse, experiment of pinpointing the problems can be terminated simultaneously
Alarm；The sample-adding hole site such as having no problem and then go to above reagent disc waits sample-adding.
4. sample-adding：Feed head can often be completed once to add on each well by sample-adding pump filling sample
Sample, reagent disc can rotate to next sample-adding hole site under the drive of motor, be added again
Sample.At the same time equally there is pressure sensor detection during being loaded, perceive and whether there is sample size not just
Often, the problems such as bubble, sample-adding can be stopped by pinpointing the problems, and be alarmed；Have no problem and then continue to be loaded, arrive
Sample-adding is completed.
It 5. is incubated：Reagent disc can keep 37 DEG C ± 0.1 DEG C of temperature simulation normal person's body temperature in reaction warehouse
Be incubated, allow required biochemical reaction to carry out, and reaction warehouse under the drive of motor with fixation
Frequency is rotated and reverse, and is moved magnetic bead in reactive tank.
6. read testing result：Image capture module is started working after certain time, when recognizing due to blood
After solidification makes magnetic bead fixed, test is completed, and is recorded this time and is uploaded test result to flat board electricity
Brain.
7. complete：End value is shown in tablet personal computer, while sample charging mechanism moves feed head giving up to side
Thing box, feed head puts in waste holder shell fragment and extracted, and disposable tip is departed from feed head.Experimenter
Hatch door is opened, used reagent disc is manually taken out, is put into the special polybag of discarded object.
2nd, Blood grouping project：
1. experiment prepares：Courageous and upright detection project reagent disc packing box is taken out, appropriate time is placed and returns to room
Wen Hou, opens packing box, takes out reagent disc, opens detector hatch door, reagent disc is loaded into reaction warehouse.
Detection blood sample is taken, is put into Riker mount.
Multiple wells and post agglutination blood are included in blood grouping reagent disk, structure reference picture 7, each reagent disc
The reactive tank of type reagent, multiple Blood grouping projects can be measured simultaneously.
2. on host computer, such as compiling and edit test procedure on tablet personal computer, selection is corresponding to be tested, and defeated
Enter the essential information of detected personnel.Confirmation equipment state is clicked on after can testing starts experiment.Instrument meeting
Detected automatically according to setting item.
3. pick up suction nozzle：Detector operates sample charging mechanism, and mobile feed head picks up suction nozzle to suction nozzle box position,
And detect whether suction nozzle is normal by pressure detection module, judge suction nozzle with the presence or absence of blocking and gas leakage；Such as
It is problematic to send alarm, remind human intervention to reappose new disposable tip；Such as have no problem, so
After be moved at Riker mount absorption sample, during drawing sample, feed head can be according to the change of pressure
Detect and whether there is bubble in sample, the material of the influence detection such as grumeleuse, experiment of pinpointing the problems can be terminated simultaneously
Alarm；The sample-adding hole site such as having no problem and then go to above reagent disc waits sample-adding.
4. sample-adding：Feed head can often be completed once to add on each well by sample-adding pump filling sample
Sample, reagent disc can rotate to next sample-adding hole site under the drive of motor, be added again
Sample.At the same time equally there is pressure sensor detection during being loaded, perceive and whether there is sample size not just
Often, the problems such as bubble, sample-adding can be stopped by pinpointing the problems, and be alarmed；Have no problem and then continue to be loaded, arrive
Sample-adding is completed.
5. centrifugation：Reagent disc is centrifuged under motor drive, and centrifugation time is about 10 minutes.
6. read testing result：After centrifugation stops, image capture module collection result image is simultaneously uploaded to flat
Plate computer is analyzed.
7. complete：End value is shown in tablet personal computer, while sample charging mechanism moves feed head giving up to side
Thing box, feed head puts in waste holder shell fragment and extracted, and disposable tip is departed from feed head.Experimenter
Hatch door is opened, used reagent disc is manually taken out, is put into the special polybag of discarded object.
3rd, immunization program：
1. experiment prepares：Immunization program reagent disc packing box is taken out, appropriate time is placed and returns to room temperature
Afterwards, packing box is opened, reagent disc is taken out, detector hatch door is opened, reagent disc is loaded into reaction warehouse.Take
Detection blood sample, is put into Riker mount.
Immunization program reagent disc, structure reference picture 8, in each reagent disc comprising multiple paired wells and
Interpretation window and colloid gold reagent, multiple immunization program detections can be measured simultaneously.
2. on host computer, such as compiling and edit test procedure on tablet personal computer, selection is corresponding to be tested, and defeated
Enter the essential information of detected personnel.Confirmation equipment state is clicked on after can testing starts experiment.Instrument meeting
Detected automatically according to setting item.
3. pick up suction nozzle：Detector operates sample charging mechanism, and mobile feed head picks up suction nozzle to suction nozzle box position,
And detect whether suction nozzle is normal by pressure detection module, judge suction nozzle with the presence or absence of blocking and gas leakage；Such as
It is problematic to send alarm, remind human intervention to reappose new disposable tip；Such as have no problem, so
After be moved at Riker mount absorption sample, during drawing sample, feed head can be according to the change of pressure
Detect and whether there is bubble in sample, the material of the influence detection such as grumeleuse, experiment of pinpointing the problems can be terminated simultaneously
Alarm；The sample-adding hole site such as having no problem and then go to above reagent disc waits sample-adding.
4. sample-adding：Feed head can often be completed once to add on each well by sample-adding pump filling sample
Sample, reagent disc can rotate to next sample-adding hole site under the drive of motor, be added again
Sample.At the same time equally there is pressure sensor detection during being loaded, perceive and whether there is sample size not just
Often, the problems such as bubble, sample-adding can be stopped by pinpointing the problems, and be alarmed；Have no problem and then continue to be loaded, arrive
Sample-adding is completed.
It 5. is incubated：Reagent disc can keep 37 DEG C ± 0.1 DEG C of temperature simulation normal person's body temperature in reaction warehouse
It is incubated.
6. read testing result：Image capture module collection result image simultaneously uploads to tablet personal computer progress
Analysis.
7. complete：End value is shown in tablet personal computer, while sample charging mechanism moves feed head giving up to side
Thing box, feed head puts in waste holder shell fragment and extracted, and disposable tip is departed from feed head.Experimenter
Hatch door is opened, used reagent disc is manually taken out, is put into the special polybag of discarded object.
Multi-purpose medical detector provided in an embodiment of the present invention and detecting system, the detector include sample-adding
Mechanism, image capture module, drive mechanism, reaction warehouse and testing result processing module；Wherein：Reaction warehouse
For the reagent disc of any one or more project in placement detection Blood coagulation test, Blood grouping and immune detection, and
And reaction warehouse bottom is provided with heater block, temperature needed for simulation and guarantee experimental situation；The driving of drive mechanism
Output shaft, in the middle part of reaction warehouse, for driving the reagent disc spins in reaction warehouse, makes detector small volume
Type；Sample charging mechanism can be accurately sample-adding in each well of reagent disc；The IMAQ mould in detection process
Block, the rotation for following reagent disc gathers at least one reagent trough or interpretation window on reagent disc successively
View data；And the view data collected, be sent to testing result processing module and analyze
To testing result；An equipment is realized in this specific embodiment can carry out the work(of a variety of methodology detections
Energy；The detector that the present embodiment is provided is used for the analytical instrument that hospital and family are detected, coordinates different detections
Reagent disc can carry out clinical immunology, and post aggegation bracket for blood grouping, cross matching, blood coagulation time is detected,
It is the compact apparatus of an All-in-One.
Obviously, those skilled in the art can carry out various changes and modification without departing from this to the present invention
The spirit and scope of invention.So, if these modifications and variations of the present invention belong to the claims in the present invention
And its within the scope of equivalent technologies, then the present invention is also intended to comprising including these changes and modification.
Claims (13)
1. a kind of multi-purpose medical detector, it is characterised in that including：Sample charging mechanism (1), driving machine
Structure (2), reaction warehouse (3), image capture module (4) and testing result processing module；
The reaction warehouse (3) be used to placing it is any in detection Blood coagulation test, Blood grouping and immune detection or
The reagent disc (5) of multiple projects, reaction warehouse (3) bottom is provided with heater block；
The drive mechanism (2) has driving output shaft (21), and the driving output shaft (21) is located at institute
State in the middle part of reaction warehouse (3), for driving the reagent disc (5) in reaction warehouse (3) to rotate；
The sample charging mechanism (1) is used to be loaded in the reagent disc (5) each well (52)；
Described image acquisition module (4) is located at the top of the reaction warehouse (3), for following reagent disc (5)
Rotation, the view data of at least one reagent trough or interpretation window on reagent disc (5) is gathered successively；
The testing result processing module, for the picture number gathered according to described image acquisition module (4)
Analyzed according to progress and obtain testing result.
2. detector as claimed in claim 1, it is characterised in that the drive mechanism (2) includes setting
Put the motor (22) in reaction warehouse (3) bottom, the output shaft (21) of the motor (22)
Be connected with external tooth gear, the external tooth gear is placed in the middle part of reaction warehouse (3), for by with reagent disc (5)
Interior internal tooth engaged transmission drives reagent disc (5) rotation；
It is circumferentially arranged in the reaction warehouse (3) to have at least three spacing guide wheels (6), in reagent disc
(5) position of reagent disc (5) is limited when rotating.
3. detector as claimed in claim 1, it is characterised in that the drive mechanism (2) includes setting
Put the motor (22) in reaction warehouse (3) bottom, the reagent disc (5) and motor (22)
Output shaft (21) between rotate coaxially.
4. detector as claimed in claim 1, it is characterised in that the sample charging mechanism (1) includes：
Transmission mechanism (11) and the feed head (12) being connected with the transmission mechanism (11).
5. detector as claimed in claim 4, it is characterised in that the feed head (12) includes：
For pressure sensor, the sample-adding pump for picking up the syringe of disposable tip and being connected with the syringe
And controller；
The pressure sensor is used to detect the air pressure in the syringe；
The sample-adding pump is used to provide power when being loaded to reagent disc (5) for syringe；
The controller is used for the air pressure detected according to the pressure sensor, with default voltage threshold
It is compared, controls the air pressure in the syringe to reach the air pressure needed for current injector working condition；
The working condition includes：Suction status, liquid relief state and sample-adding state.
6. detector as claimed in claim 5, it is characterised in that the controller is additionally operable in sample-adding
During the syringe pickup disposable tip of head (12), detected by the pressure sensor in syringe
Air pressure, determine whether disposable tip damaged or blocks.
7. detector as claimed in claim 5, it is characterised in that the controller is additionally operable in sample-adding
During the syringe pickup disposable tip of head (12), detected by the pressure sensor in syringe
Air pressure change, determine in sample whether there is bubble or grumeleuse.
8. detector as claimed in claim 4, it is characterised in that the transmission mechanism (11) includes：
X-axis movement arm, Y-axis movement arm and Z axis movement arm；X-axis, Y-axis and Z axis are rectangular coordinate system in space
In reference axis；
The two ends of X-axis movement arm and Y-axis movement arm respectively with Z axis movement arm are connected；
Motor, the slip for connecting the screw mandrel of motor and being enclosed on screw mandrel are provided with each movement arm
Block, is rotated by motor drive screw, drives sliding shoe to slide；
The feed head (12) is fixed on higher that in position in both X-axis movement arm and Y-axis movement arm
On the sliding shoe of individual movement arm.
9. detector as claimed in claim 1, it is characterised in that the heating part of the reaction warehouse (3)
Part is the heating film for being covered in reaction warehouse (3) bottom, and the heating film enables to warm in reaction warehouse (3)
Stability contorting is spent in preset temperature.
10. detector as claimed in claim 1, it is characterised in that the detector is additionally provided with waste
Provided with least two panels shell fragment at box (7), waste holder (7) open top, the opening, for card
Firmly the disposable tip on feed head (12) causes feed head (12) to be separated with the disposable tip.
11. detector as claimed in claim 1, it is characterised in that the detector also includes suction nozzle box
(8), it is placed with disposable tip in the suction nozzle box (8).
12. detector as claimed in claim 1, it is characterised in that the testing result processing module is led to
Cross the view data of wired or wireless receiving described image acquisition module (4) collection.
13. a kind of multi-purpose medical detecting system, it is characterised in that including reagent disc (5) and such as right
It is required that the detector described in any one of 1-12；The reagent disc (5) is in annular, including at least one is anti-
Answer groove (51)；
At least one described reactive tank (51) is one of the following or any combination：
Reactive tank (51) comprising well (52), magnetic bead (53) and Blood coagulation test reagent；
Reactive tank (51) comprising well (52) and Blood grouping reagent；
Reactive tank (51) comprising well (52), interpretation window (54) and immunologic function test reagent.
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| CN201610218215.XA CN107271701B (en) | 2016-04-08 | 2016-04-08 | A kind of multi-purpose medical detector and detection system |
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| CN107271701B (en) | 2019-06-11 |
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