CN103048286B - Diabetes detection analyzer - Google Patents
Diabetes detection analyzer Download PDFInfo
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- CN103048286B CN103048286B CN201210576354.1A CN201210576354A CN103048286B CN 103048286 B CN103048286 B CN 103048286B CN 201210576354 A CN201210576354 A CN 201210576354A CN 103048286 B CN103048286 B CN 103048286B
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Abstract
The invention relates to a diabetes detection analyzer, which comprises a detection analyzer body; a central processor, a power module and a real-time blood sugar content detection unit are arranged in the detection analyzer body; the real-time blood sugar content detection unit comprises a signal acquisition and preprocessing device based on a reagent absorbance analysis principle, a constant temperature device and a stirring device; a reagent cavity used for mounting a reagent to be tested is arranged on the constant temperature device; an albumin glycation ratio detection unit used for detecting the average blood sugar content of a patient in 2-3 weeks is also arranged in the detection analyzer body; and the albumin saccharification ratio detection unit comprises a glycated albumin detection unit and an albumin detection unit which have the same structure as the real-time blood sugar content detection unit. The diabetes detection analyzer is low in price and simple and convenient to use, and can be used for detecting the real-time blood sugar content and the average blood sugar content of 2-3 weeks in a blood sample of the patient at the same time.
Description
Technical field
The present invention relates to diabetes and detect analysis technical field, specifically refer to that a kind of diabetes detect analyser.
Background technology
The treatment key of diabetes is that the control of blood sugar level is with stable, at present clinically common method be by glucose content in sampling Detection blood samples of patients (below by the glucose in blood referred to as blood sugar, by the glucose content in blood referred to as blood-sugar content) monitor the blood sugar level of patient, but just single drawn by the glucose content in direct-detection blood be actually the real time blood sugar content of user at sampling observation time point, it be subject to inspect by random samples patient in the time period diet and take medicine the impact of thing etc., the truth of blood sugar in patient body can not be objectively responded, and the change of blood in human body in sugar is originally very large in the middle of one day, only according to the sampling observation time period, this index of blood-sugar content of point has certain limitation to making a definite diagnosis diabetes.
For this reason, medical circle is drawn by long-term clinical research, and the blood-sugar content that glycated protein can be in long period section in patient's body provides review evaluation, and not by the impact of parameters of short term glycemic content fluctuation, more accurately can judge the blood sugar level that patient is real.Albuminous saccharification in particularly described glycated protein is than the average blood sugar content that can reflect the past 2 ~ 3 weeks of patient, more definitely and in time can reflect blood sugar level when change of blood sugar is the most remarkable, be particularly useful for the observation of curative effect of new diagnosis patient when glucose-lowering treatment that blood glucose fluctuation is larger.Therefore, the common detection of both combinations above-mentioned can be improved the diagnosis accuracy of diabetes and the level monitoring of patient blood glucose's actual state.
But the small-sized detecting instrument of the average blood sugar content two indices of the real time blood sugar content also not having in the market simultaneously to detect in blood samples of patients sample and 2 ~ 3 weeks.Only there is the small-sized detecting instrument carrying out individual event detection for real time blood sugar content's index in These parameters, as the blood glucose meter that German Roche is produced; The small-sized detecting instrument separately carrying out detecting for the average blood sugar content of 2 ~ 3 weeks is also without like product.If need to detect above-mentioned two indices simultaneously, in the detector of prior art, only have large-scale biochemical instruments just can accomplish, but large-scale biochemical instruments is not specially for the detecting instrument of diabetes, it once can detect and analyze up to a hundred indexs, expensive, require high to operating personnel's technical merit, equipment maintenance cost is high, cause basic hospital not have ability to be carried out by large-scale biochemical instruments to detect the real time blood sugar content of blood samples of patients sample and the average blood sugar content two indices of 2 ~ 3 weeks simultaneously, even if detect together large hospital multiple patient that also needs to gather together enough.Based on above-mentioned background, the diabetes being badly in need of now the average blood sugar content two indices of a kind of cheap, easy to use and real time blood sugar content that at least can simultaneously detect in blood samples of patients sample and 2 ~ 3 weeks detect analyser.
It is inconvenient also to there is door switch in configuration aspects in simultaneously commercially available in the prior art small-sized detecting instrument for single index, can not the problem of automatic switch; Stirring apparatus on detecting unit does not have fixed point remaining function, the position that agitation beads stops at every turn is all random, the position causing the absorbance for detecting blood samples of patients sample to be popped one's head in must exceed agitation beads, this makes detector require when detecting sample, and the liquid level of sample is higher, causes the problem of the waste of test agent to a certain extent; Be exactly isothermal block on detecting unit be in addition the some connected mode adopted with heating arrangement, namely heating arrangement is only connected with the very little region of on isothermal block, isothermal block is caused to heat uneven, first hot near one end of heating arrangement, away from the problem of one end after heat of heating arrangement.
Summary of the invention
The technical problem to be solved in the present invention is, provides the diabetes of the average blood sugar content two indices of a kind of cheap, easy to use and real time blood sugar content that can simultaneously detect in blood samples of patients sample and 2 ~ 3 weeks to detect analyser.
For solving the problems of the technologies described above, technical scheme provided by the invention is: a kind of diabetes detect analyser, and it comprises detects analyser main body; Detect in analyser main body and be provided with central processing unit, power module, real time blood sugar content detection unit; Power module is electrically connected with central processing unit and real time blood sugar content detection unit respectively; Real time blood sugar content detection unit is electrically connected with central processing unit; Described real time blood sugar content detection unit comprises signals collecting based on reagent spectrophotometric analysis principle and pretreatment unit, thermostat and stirring apparatus; Thermostat is provided with the reagent chamber for laying test agent, and signals collecting and pretreatment unit are arranged on thermostat, and signals collecting and pretreatment unit comprise absorbance and pop one's head in and signal pre-processing module, and stirring apparatus is positioned at the below of reagent chamber; Described diabetes detect the albuminous saccharification be also provided with for detecting patient's average blood sugar content of 2 ~ 3 weeks in analyser main body and compare detecting unit, described albuminous saccharification comprises glycosylated albumin detecting unit and albumin detecting unit than detecting unit, and described glycosylated albumin detecting unit is all identical with the structure of real time blood sugar content detection unit with the structure of albumin detecting unit and be all electrically connected with central processing unit and power module; Also be provided with for detecting the cuvette position sensor whether being placed with the cuvette holding reagent in reagent chamber in described analyser main body, described cuvette position sensor is photoelectric sensor, and described cuvette position sensor is electrically connected with central processing unit.
After adopting above structure, tool of the present invention has the following advantages: the average blood sugar content two indices that can be drawn real time blood sugar content in blood sample and 2 ~ 3 weeks by real time blood sugar content detection unit, albuminous saccharification than the combination that detecting unit comprises glycosylated albumin detecting unit and albumin detecting unit three unit respectively.And described diabetes detection analyser detects based on absorbance principle, described signals collecting and pretreatment unit, thermostat and stirring apparatus volume is little, cost is low, use also very simple, this structure (cuvette position sensor) can allow in central processing unit Confirmation reagent chamber whether be placed with the cuvette holding reagent, thus better control the action of other parts such as thermostat module, prevent invalid operation from occurring.
As improvement, also be provided with the glycosylated hemoglobin detecting unit for detect the patient average blood sugar content of 7 ~ 8 week identical with the structure of real time blood sugar content detection unit in described detection analyser main body, described glycosylated hemoglobin detecting unit is electrically connected with central processing unit and power module.Glycosylated hemoglobin in described glycated protein can reflect the average blood glucose levels in patient's 8 ~ l2 week in past, and not by the impact of parameters of short term glycemic content fluctuation, by blood glucose control and clinical trial association, be called for short DCCT, be recommended as glycemic control test " goldstandard ", have good reference value to the blood sugar level reflecting patient exactly.And it is not high based on the detecting unit cost of reagent spectrophotometric analysis principle.
As preferably, be provided with reaction warehouse in described analyser main body, described reaction warehouse comprises door and door bucket; Described door is located on the sidewall of analyser main body, the thermostat of described real time blood sugar content detection unit, glycosylated hemoglobin detecting unit, glycosylated albumin detecting unit and albumin detecting unit four unit, stirring apparatus and signals collecting and pretreatment unit are all installed on door bucket, described door bucket is fixedly connected with door, and lower end and the analyser main body of described door bucket are hinged.This structure adopts tipping bucket type design, when will test agent be placed or take out test agent in door bucket in door bucket, only need door bucket outwards to overturn can open door bucket, user can place test agent very easily or take out test agent in door bucket in door bucket.
As preferably, be also provided with door motor in described analyser main body, the output shaft of described door motor is connected with crank, and door bucket sidewall is provided with the crank guiding groove matched with crank.Electric structure, can substitute and manually realize switch to door, automaticity is higher.
As preferably, inwall corresponding with the sidewall of door bucket in described analyser main body is also provided with close the door detecting device and enabling detecting device; The sidewall of described door bucket is then provided with and senses corresponding pass gate signal and the sensor block of enabling signal for make to close the door detecting device and enabling detecting device; Described detecting device and the enabling detecting device of closing the door is Hall element, and described sensor block is magnet.Switch gate detects, and can prevent opening by mistake or closing by mistake of door; Effectively can also guarantee that each switch motion of door puts in place.Further optimize the automatic control of analyser main body to door.And Hall element is non-contact sensor, easy for installation, accuracy of detection is high.
As preferably, described real time blood sugar content detection unit also comprises reagent mixing arrangement, described reagent mixing arrangement comprises linear electric motors, described linear electric motors are electrically connected with central processing unit, described linear electric motors are provided with the screw mandrel that can pump, and described screw mandrel is positioned at the top of reagent chamber.The screw mandrel of linear electric motors can coordinate special double-deck cuvette to use, and the reagent on cuvette upper strata is headed into cuvette lower floor by screw mandrel, thus makes two kinds of Reagent evaluation mutual reactances.This structure well instead of manual operation, and it is more accurate to the assurance of the time of two kinds of reaction reagent mixing to make to detect in analytic process.
As preferably, the linear electric motors screw mandrel position transducer whether resetted smoothly for detecting screw mandrel is also provided with in described analyser main body, described linear electric motors screw mandrel position transducer is photoelectric sensor, and described linear electric motors screw mandrel position transducer is electrically connected with central processing unit.
As preferably, described thermostat comprises heat-conducting seat, and described heat-conducting seat is hexahedron structure, and heat-conducting seat is provided with reagent chamber, is wound with heating wire in heat-conducting seat; Also temperature sensor is provided with in heat-conducting seat; Heater switch and the temperature sensor of described heating wire are electrically connected with central processing unit; Described heat-conducting seat is also provided with the probe mounting holes that the absorbance for installing on signals collecting and pretreatment unit is popped one's head in.Heating wire winding is on heat-conducting seat, and heating is that heat-conducting seat is heated more evenly, also has temperature sensor to carry out monitoring temperature simultaneously, can well realize thermostatic control.
As preferably, described stirring apparatus comprises stirring motor, stirring motor steady arm, agitation beads and rotating disk; The rotating shaft of stirring motor is connected with rotating disk, and the upper end eccentric part of described rotating disk is provided with for being driven the magnet stirring steel ball and rotate in the cuvette holding reagent by magnetic field; Described rotating disk is provided with the inductive means for coordinating stirring motor steady arm to locate; Described stirring motor steady arm is photoelectric sensor, and the rotation path of described inductive means passes the detection light beam of stirring motor steady arm; Described stirring motor steady arm, stirring motor are all electrically connected with central processing unit, and described stirring motor is the motor with braking function.Central processing unit by reading the position of inductive means on magnetic stirring apparatus, can send the series of orders such as rotations, deceleration or braking to stirring motor, finally allow the magnet on rotating disk be parked in a fixing predeterminated position.The nature agitation beads corresponding with magnet also can be parked in a corresponding fixed position.Now user only needs the transmitting terminal of absorbance being popped one's head in can ensure to detect each stop not being subject to agitation beads of light beam with the relative side that receiving end is arranged at the position that agitation beads is stopped, detection can be completed smoothly, and not require that the liquid level of test agent must higher than agitation beads.Detect so each and just can complete by less test agent.Thus the invention provides a kind of magnetic stirring apparatus for reagent analyzer more saving test agent.
Accompanying drawing explanation
Fig. 1 is the main structure block scheme that diabetes of the present invention detect analyser.
Fig. 2 is the circuit block diagram that diabetes of the present invention detect analyser.
Fig. 3 is the structural representation that diabetes of the present invention detect analyser.
Fig. 4 is the structural representation of product under door open mode of Fig. 3.
Fig. 5 is the structural representation after Fig. 3 removes upper cover.
Fig. 6 is the structural representation that diabetes of the present invention detect the core of analyser.
Fig. 7 is the structural representation after Fig. 6 rotates to an angle.
Fig. 8 is the structural representation of the tipping bucket type assembly that diabetes of the present invention detection analyser and door are affixed.
Fig. 9 is the structural representation after Fig. 6 removes door.
Figure 10 is the structural representation of Fig. 9 under perspective view.
Figure 11 Fig. 6 removes the structural representation after linear electric motors part.
Figure 12 is the structural representation of Figure 11 under the state of overlooking.
Figure 13 is at the partial structurtes schematic diagram of the next detecting unit of the situation not putting into cuvette.
Figure 14 is at the complete structural representation of the next detecting unit of the situation not putting into cuvette.
Figure 15 is the structural representation that diabetes of the present invention detect the heat-conducting seat on analyser.
Figure 16 is the vertical view of Figure 15.
Figure 17 is the upward view of Figure 15.
Figure 18 is the cut-open view of Figure 15.
Figure 19 is applicable to the structural representation that diabetes of the present invention detect the cuvette of analyser.
The structural representation of the sub-cup in Figure 20 Figure 19.
Figure 21 be the reagent in the cuvette in Figure 14 mixed after structural representation.
As shown in the figure: 1, central processing unit, 2, printer, 3, card reader, 4, real time blood sugar content detection unit, 5, albumin saccharification than pick-up unit, 6, glycosylated hemoglobin detecting unit, 7, glycosylated albumin detecting unit, 8, albumin detecting unit, 9, signals collecting and pretreatment unit, 10, thermostat, 11, stirring apparatus, 12, reagent mixing arrangement, 13, power module, 14, stylus printer, 16, door motor, 17, door position transducer, 18, linear electric motors, 19, stirring motor, 22, cuvette position sensor, 23, linear electric motors screw mandrel position transducer, 24, display screen, 31, detect analyser main body, 32, door, 33, door bucket, 34, cuvette guide plate, 36, crank, 37, motor mount, 38, rotational pin, 39, crank guiding groove, 40, to close the door detecting device, 41, enabling detecting device, 42, linear electric motors, 43, screw mandrel, 44, heat-conducting seat, 45, light guide plate, 46, heating wire, 47, stirring motor, 48, absorbance is popped one's head in, and 49, stirring motor steady arm, 50, rotating disk, 51, first detecting unit, 52, second detecting unit, 53, 3rd detecting unit, 54, 4th detecting unit, 55, magnet, 56, cuvette, 57, linear electric motors mount pad, 58, agitation beads, 4401, reagent chamber, 4402, first groove, 4403, wire hole, 4404, probe mounting holes, 4405, heat-conducting seat fixed orifice, 4406, second groove, 5601, first test tube plug, 5602, sub-cup, 5603, second chamber, 5604, second test tube plug, 5605, first chamber, 5606, female cup.
Embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail.
By reference to the accompanying drawings 1 to 21, a kind of diabetes detect analyser, and it comprises detects analyser main body 31; Detect in analyser main body 31 and be provided with central processing unit 1, power module 13, real time blood sugar content detection unit 4; Power module 13 is electrically connected with central processing unit 1 and real time blood sugar content detection unit 4 respectively; Real time blood sugar content detection unit 4 is electrically connected with central processing unit 1; Described real time blood sugar content detection unit 4 comprises signals collecting based on reagent spectrophotometric analysis principle and pretreatment unit 9, thermostat 10 and stirring apparatus 11; Thermostat 10 is provided with the reagent chamber 4401 for laying test agent, signals collecting and pretreatment unit 9 are arranged on thermostat 10, signals collecting and pretreatment unit 9 comprise absorbance and to pop one's head in 48 and signal pre-processing module, and stirring apparatus 11 is positioned at the below of reagent chamber 4401; Albuminous saccharification for detecting patient's average blood sugar content of 2 ~ 3 weeks is also provided with than detecting unit 5 in described detection analyser main body 31, described albuminous saccharification comprises glycosylated albumin detecting unit 7 and albumin detecting unit 8 than detecting unit 5, and described glycosylated albumin detecting unit 7 is all identical with the structure of real time blood sugar content detection unit 4 with the structure of albumin detecting unit 8 and be all electrically connected with central processing unit 1 and power module 13.Also be provided with the glycosylated hemoglobin detecting unit 6 for detect the patient average blood sugar content of 7 ~ 8 week identical with the structure of real time blood sugar content detection unit 4 in described detection analyser main body 31, described glycosylated hemoglobin detecting unit 6 is electrically connected with central processing unit 1 and power module 13.Be provided with reaction warehouse in described analyser main body 31, described reaction warehouse comprises door 32 and door bucket 33; Described door 32 is located on the sidewall of analyser main body 31, the thermostat 10 of described real time blood sugar content detection unit 4, glycosylated hemoglobin detecting unit 6, glycosylated albumin detecting unit 7 and albumin detecting unit 8 four unit, stirring apparatus 11 and signals collecting and pretreatment unit 9 are all installed on door bucket 33, described door bucket 33 is fixedly connected with door 32, and lower end and the analyser main body 31 of described door bucket 33 are hinged.Also be provided with door motor 16 in described analyser main body 31, the output shaft of described door motor 16 is connected with crank 36, and door bucket 33 sidewall is provided with the crank guiding groove 39 matched with crank 36.Inwall corresponding with the sidewall of door bucket 33 in described analyser main body 31 is also provided with close the door detecting device 40 and enabling detecting device 41; The sidewall of described door bucket 33 is then provided with and senses corresponding pass gate signal and the sensor block of enabling signal for make to close the door detecting device 40 and enabling detecting device 41; Described detecting device 40 and the enabling detecting device 41 of closing the door is Hall element, and described sensor block is magnet.Described real time blood sugar content detection unit 4 also comprises reagent mixing arrangement 12, described reagent mixing arrangement 12 comprises linear electric motors 18, described linear electric motors 8 are electrically connected with central processing unit 1, described linear electric motors 8 are provided with the screw mandrel 43 that can pump, and described screw mandrel 43 is positioned at the top of reagent chamber 4401.The linear electric motors screw mandrel position transducer 23 whether resetted smoothly for detecting screw mandrel 43 is also provided with in described analyser main body 31, described linear electric motors screw mandrel position transducer 23 is photoelectric sensor, and described linear electric motors screw mandrel position transducer 23 is electrically connected with central processing unit 1.Also be provided with for detecting the cuvette position sensor 22 whether being placed with the cuvette holding reagent in reagent chamber 4401 in described analyser main body 31, described cuvette position sensor 22 is photoelectric sensor, and described cuvette position sensor 22 is electrically connected with central processing unit 1.Described thermostat 10 comprises heat-conducting seat 44, and described heat-conducting seat 44 is in hexahedron structure, and can also be arranged to other polyhedral structure during concrete enforcement, heat-conducting seat 44 is provided with reagent chamber 4401, is wound with heating wire 46 in heat-conducting seat 44; Also temperature sensor is provided with in heat-conducting seat 44; Heater switch and the temperature sensor of described heating wire 46 are electrically connected with central processing unit 1; Described heat-conducting seat 44 is also provided with to pop one's head in for the absorbance of installing on signals collecting and pretreatment unit 9 48 probe mounting holes 4404.Described stirring apparatus 11 comprises stirring motor 47, stirring motor steady arm 49, agitation beads 58 and rotating disk 50; The rotating shaft of stirring motor 47 is connected with rotating disk 50, and the upper end eccentric part of described rotating disk 50 is provided with for being driven the magnet 55 stirring steel ball and rotate in the cuvette holding reagent by magnetic field; Described rotating disk 50 is provided with the inductive means for coordinating stirring motor steady arm 49 to locate; Described stirring motor steady arm 49 is photoelectric sensor, and the rotation path of described inductive means passes the detection light beam of stirring motor steady arm 49; Described stirring motor steady arm 49, stirring motor 47 are all electrically connected with central processing unit 1, and described stirring motor 47 is the motor with braking function.
The present invention in the specific implementation, glycosylated hemoglobin in described glycated protein can reflect the average blood glucose levels in patient's 8 ~ l2 week in past, and not by the impact of parameters of short term glycemic content fluctuation, be recommended as glycemic control test " goldstandard " by blood glucose control and clinical trial association DCCT, but its detection accuracy is still by being permitted multifactor impact, concerning a part of diabetic, glycated hemoglobin levels can not reflect their average blood glucose levels and diabetic complication exactly, causes testing result to be also affected; Therefore the present invention is only to provide a reference by the index of the glycosylated hemoglobin in the glycated protein detected by absorbance principle.If described diabetes detect analyser and adopt linear electric motors in the specific implementation, then need to support the use corresponding double-deck cuvette, as shown in accompanying drawing 19 to accompanying drawing 21, described double-deck cuvette comprises female cup 5606 and sub-cup 5602, sub-glass holder is on female cup, the first test tube plug 5601 is stamped in the upper end of described sub-cup 5602, the lower end of described sub-cup 5602 is provided with the second test tube plug 5604, defining one between first test tube plug 5601 and the second test tube plug 5604 can the first chamber 5605 of accommodating a kind of reaction reagent, cavity in female cup of the lower end of described sub-cup 5602 is then the second chamber 5603 for holding sample, second test tube plug 5604 is that a simple enclosure-type card is joined with the lower end of sub-cup, when the screw mandrel of linear electric motors extrudes the first test tube plug 5601 downwards, effect second test tube plug 5604 be stressed is subject to falling in the second chamber 5603, reagent now then in sub-cup mixes mutually with the sample reagent in female cup.As everyone knows, often need to add one or both reaction reagents at the analysis field of reagent, adopt the cuvette of above-mentioned double-layer structure well to achieve the action of electronic mix reagent.Convenience in order to use in described analyser main body 31 is also provided with printer 2, card reader 3 and display screen 24.Described printer 2 generally adopts stylus printer 14, and described card reader 3 generally adopts IC-card card reader, and card reader 3 is for reading the parameter of the reaction reagent added in sample.Described display screen 24 can adopt the screen of band touch-control also can not, with the screen of touch-control, if be not with touch-control, then to need to configure keypad in addition.Described printer 2, card reader 3 and display screen 24 are all electrically connected with central processing unit 1, and described central processing unit 1 can adopt the processor of the realized programming Control that single-chip microcomputer, arm processor or rank are higher.Described cuvette position sensor 22 is a pair photoelectric probe, it comprises transmitting terminal and receiving end, in order to ensure that the light beam between transmitting terminal and receiving end can smoothly for detecting, light guide plate 45 is also provided with between transmitting terminal and receiving end, described light guide plate is generally installed on door bucket nearby, described light guide plate 45 is provided with a light-conductive hole for making light pass through, specifically as shown in figure 14.In order to prevent the cuvette position sensor 22 between neighbouring detecting elements from interfering with each other, be also provided with one piece of light barrier between neighbouring detecting elements, launch from neighbouring detecting elements the detection light beam of coming for blocking, this structure has in fig. 10 and clearly shows.Described door motor 16, when specifically arranging, is installed on motor mount 37, and door bucket is then hinged by rotational pin 38 and door main body, and this type of radial type structure belongs to general knowledge relative to those skilled in the art, no longer describes in detail herein.The first detecting unit 51, second detecting unit 52, the 3rd detecting unit 53 and the 4th detecting unit 54 shown in accompanying drawing correspond respectively to real time blood sugar content detection unit 4, glycosylated albumin detecting unit 7, albumin detecting unit 8 and glycosylated hemoglobin detecting unit 6.Described glycosylated albumin detecting unit 7 and albumin detecting unit 8 are one group, namely central processing unit draws described albuminous saccharification ratio by the data detected by glycosylated albumin detecting unit 7 divided by the data that albumin detecting unit 8 detects, this ratio is generally acknowledged through medical circle, can be used for the reaction patient average blood sugar content of 2 ~ 3 weeks.The present invention can also come the position of detection of straight lines motor lead screw 43 in the specific implementation by arranging linear electric motors screw mandrel position transducer 23, thus the running of linear electric motors is carried out under feedback, and degree of accuracy is higher.Heat-conducting seat described in being exactly in addition, in order to the convenience of installation and use, it is also provided with wire hole 4403, probe mounting holes 4404, the structures such as heat-conducting seat fixed orifice 4405, first groove 4402 and the second groove 4406.Wherein the first groove 4402 and the second groove 4406 are arranged in order to two end faces up and down not allowing heating wire 46 protrude from heat-conducting seat.Other above-mentioned parts are then arranged to install each corresponding accessory.Described door bucket is also provided with the cuvette guide plate 34 being convenient to insert cuvette.Be an annular radial projection about the inductive means described in the inductive means for coordinating stirring motor steady arm 49 to locate, described annular radial projection is provided with a breach extended along rotating disk radial direction; Described detection part is photoelectric sensor, and described photoelectric sensor comprises transmitting terminal and receiving end, responds to mutually between transmitting terminal and receiving end by detecting light beam; The rotate path of described annular radial projection is through the detection light beam transmitting terminal and receiving end.This structure by breach arrange breach just can be forwarded between transmitting terminal and receiving end by programming time, by motor braking, magnet positions is fixed, it is convenient to locate.As another kind of embodiment, described inductive means can also be radial projection; Described detection part is photoelectric sensor, and described photoelectric sensor comprises transmitting terminal and receiving end, responds to mutually between transmitting terminal and receiving end by detecting light beam; The rotate path of described radial projection is through the detection light beam transmitting terminal and receiving end.This structure by radial projection arrange projection just can be forwarded between transmitting terminal and receiving end by programming time, by motor braking, magnet positions is fixed, same location is convenient.Described agitation beads is the magnetic stainless steel ball that can be magnetically attracted.Stainless steel ball can well coordinate with magnet, under the attraction of magnet, rotates together with rotating disk.Stainless steel ball stable performance simultaneously, not easily reacts with test agent, does not pollute reaction reagent, can not have influence on testing result.Described detection part and stirring motor are all electrically connected with central processing unit 1.Each described detecting unit structure is identical, but the wavelength of absorbance probe corresponding in each unit is different, different wavelength is for detecting different indexs, this point has special conversion form in absorbance detection field, belong to those skilled in the art general knowledge, 500nm can be set to for the wavelength of the absorbance probe detecting the detecting unit of real time blood sugar content in the present invention, wavelength for the absorbance probe detecting two unit of albumin saccharification ratio can be set to 600nm, and the wavelength for the absorbance probe detecting content of hemoglobin can be set to 700nm.But this wavelength is not fixing, it is also by the impact of reaction reagent, and different reaction reagents needs to do some to probe wavelength and revises, and concrete modification method also has special conversion form in absorbance detection field, belongs to those skilled in the art general knowledge.
Be described the present invention and embodiment thereof above, this description does not have restricted, and shown in accompanying drawing is also one of embodiments of the present invention, and actual structure is not limited thereto.If generally speaking those of ordinary skill in the art enlightens by it, when not departing from the invention aim, designing the frame mode similar to this technical scheme and embodiment without creationary, all should protection scope of the present invention be belonged to.
Claims (9)
1. diabetes detect an analyser, and it comprises detects analyser main body (31), detect in analyser main body (31) and be provided with central processing unit (1), power module (13), real time blood sugar content detection unit (4), power module (13) is electrically connected with central processing unit (1) and real time blood sugar content detection unit (4) respectively, real time blood sugar content detection unit (4) is electrically connected with central processing unit (1), described real time blood sugar content detection unit (4) comprises signals collecting based on reagent spectrophotometric analysis principle and pretreatment unit (9), thermostat (10) and stirring apparatus (11), thermostat (10) is provided with the reagent chamber (4401) for laying test agent, signals collecting and pretreatment unit (9) are arranged on thermostat (10), signals collecting and pretreatment unit (9) comprise absorbance and to pop one's head in (48) and signal pre-processing module, and stirring apparatus (11) is positioned at the below of reagent chamber (4401), it is characterized in that: be also provided with albuminous saccharification for detecting patient's average blood sugar content of 2 ~ 3 weeks in described detection analyser main body (31) than detecting unit (5), described albuminous saccharification comprises glycosylated albumin detecting unit (7) and albumin detecting unit (8) than detecting unit (5), described glycosylated albumin detecting unit (7) is all identical with the structure of real time blood sugar content detection unit (4) with the structure of albumin detecting unit (8) and be all electrically connected with central processing unit (1) and power module (13), also be provided with for detecting the cuvette position sensor (22) whether being placed with the cuvette holding reagent in reagent chamber (4401) in described analyser main body (31), described cuvette position sensor (22) is photoelectric sensor, and described cuvette position sensor (22) is electrically connected with central processing unit (1).
2. diabetes according to claim 1 detect analyser, it is characterized in that: be also provided with the glycosylated hemoglobin detecting unit (6) for detect the patient average blood sugar content of 7 ~ 8 week identical with the structure of real time blood sugar content detection unit (4) in described detection analyser main body (31), described glycosylated hemoglobin detecting unit (6) is electrically connected with central processing unit (1) and power module (13).
3. diabetes according to claim 2 detect analyser, and it is characterized in that: be provided with reaction warehouse in described analyser main body (31), described reaction warehouse comprises door (32) and door bucket (33), described door (32) is located on the sidewall of analyser main body (31), described real time blood sugar content detection unit (4), glycosylated hemoglobin detecting unit (6), the thermostat (10) of glycosylated albumin detecting unit (7) and albumin detecting unit (8) four unit, stirring apparatus (11) and signals collecting and pretreatment unit (9) are all installed on door bucket (33), described door bucket (33) is fixedly connected with door (32), lower end and the analyser main body (31) of described door bucket (33) are hinged.
4. diabetes according to claim 3 detect analyser, it is characterized in that: in described analyser main body (31), be also provided with door motor (16), the output shaft of described door motor (16) is connected with crank (36), and door bucket (33) sidewall is provided with the crank guiding groove (39) matched with crank (36).
5. diabetes according to claim 3 detect analyser, it is characterized in that: inwall corresponding with the sidewall of door bucket (33) in described analyser main body (31) is also provided with detecting device of closing the door (40) and enabling detecting device (41); The sidewall of described door bucket (33) is then provided with and senses corresponding pass gate signal and the sensor block of enabling signal for make to close the door detecting device (40) and enabling detecting device (41); Described detecting device of closing the door (40) and enabling detecting device (41) are Hall element, and described sensor block is magnet.
6. diabetes according to claim 1 detect analyser, it is characterized in that: described real time blood sugar content detection unit (4) also comprises reagent mixing arrangement (12), described reagent mixing arrangement (12) comprises linear electric motors (18), described linear electric motors (8) are electrically connected with central processing unit (1), described linear electric motors (8) are provided with the screw mandrel (43) that can pump, and described screw mandrel (43) is positioned at the top of reagent chamber (4401).
7. diabetes according to claim 6 detect analyser, it is characterized in that: in described analyser main body (31), be also provided with the linear electric motors screw mandrel position transducer (23) whether resetted smoothly for detecting screw mandrel (43), described linear electric motors screw mandrel position transducer (23) is photoelectric sensor, and described linear electric motors screw mandrel position transducer (23) is electrically connected with central processing unit (1).
8. diabetes according to claim 1 detect analyser, it is characterized in that: described thermostat (10) comprises heat-conducting seat (44), described heat-conducting seat (44) is in hexahedron structure, heat-conducting seat (44) is provided with reagent chamber (4401), is wound with heating wire (46) in heat-conducting seat (44); Heat-conducting seat is also provided with temperature sensor in (44); Heater switch and the temperature sensor of described heating wire (46) are electrically connected with central processing unit (1); Described heat-conducting seat (44) is also provided with the probe mounting holes (4404) of to pop one's head in for the absorbance of installing on signals collecting and pretreatment unit (9) (48).
9. diabetes according to claim 1 detect analyser, it is characterized in that: described stirring apparatus (11) comprises stirring motor (47), stirring motor steady arm (49), agitation beads (58) and rotating disk (50); The rotating shaft of stirring motor (47) is connected with rotating disk (50), and the upper end eccentric part of described rotating disk (50) is provided with for being driven the magnet (55) stirring steel ball and rotate in the cuvette holding reagent by magnetic field; Described rotating disk (50) is provided with the inductive means for coordinating stirring motor steady arm (49) to locate; Described stirring motor steady arm (49) is photoelectric sensor, and the rotation path of described inductive means passes the detection light beam of stirring motor steady arm (49); Described stirring motor steady arm (49), stirring motor (47) are all electrically connected with central processing unit (1), and described stirring motor (47) is the motor with braking function.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210576354.1A CN103048286B (en) | 2012-12-26 | 2012-12-26 | Diabetes detection analyzer |
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| CN201210576354.1A CN103048286B (en) | 2012-12-26 | 2012-12-26 | Diabetes detection analyzer |
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| CN103048286B true CN103048286B (en) | 2015-01-14 |
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| CN104713861B (en) * | 2015-03-17 | 2017-11-21 | 江苏量点科技有限公司 | Dark chamber and the vitro detection analytical equipment using the dark chamber |
| CN109738662A (en) * | 2019-03-07 | 2019-05-10 | 深圳奥萨制药有限公司 | A kind of POCT Biochemical Analyzer with multi-channel detection |
| CN109782001A (en) * | 2019-03-27 | 2019-05-21 | 苏州康和顺医疗技术有限公司 | A kind of household protein analyzer stirring system and its stirring means |
| CN110261326A (en) * | 2019-07-15 | 2019-09-20 | 杭州德译医疗科技有限公司 | Detection probe base device |
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| US6103033A (en) * | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
| US7419821B2 (en) * | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
| CN1588089A (en) * | 2004-09-03 | 2005-03-02 | 上海艾诺电子有限公司 | Automatic loading and unloading system for full automatic biochemical analyzer clorimetric cup and its control method |
| US9429579B2 (en) * | 2006-09-22 | 2016-08-30 | Arkray, Inc. | Blood analysis apparatus |
| US8591410B2 (en) * | 2008-05-30 | 2013-11-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing glycemic control |
| CN202947966U (en) * | 2012-12-26 | 2013-05-22 | 宁波美康盛德生物科技有限公司 | Detection and analysis instrument for diabetes mellitus |
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