CN203232038U - Full automatic chemiluminiscence biochip scanner - Google Patents
Full automatic chemiluminiscence biochip scanner Download PDFInfo
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- CN203232038U CN203232038U CN 201320249167 CN201320249167U CN203232038U CN 203232038 U CN203232038 U CN 203232038U CN 201320249167 CN201320249167 CN 201320249167 CN 201320249167 U CN201320249167 U CN 201320249167U CN 203232038 U CN203232038 U CN 203232038U
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Abstract
The utility model relates to a biochip scanner, and particularly relates to a full automatic chemiluminiscence biochip scanner. The scanner comprises a motion control system, a signal collecting and processing system, a liquid cycle control system, an environment monitor control system, a support plate information recognition system, and a control core, wherein the control core is used for connecting and cooperatively controlling the motion control system, the signal collecting and processing system, the liquid cycle control system, the environment monitor control system and the support plate information recognition system. According to the scanner provided by the utility model for automatically scanning and reading the chemiluminiscence biochip information, the chemiluminiscence biochip information can be read automatically, the scanning speed is improved, the scanning error is lowered, the work efficiency is improved, and the system has high running reliability.
Description
Technical field
The utility model relates to a kind of biological chip scanning device, especially relates to full-automatic chemical luminous organism chip scanner.
Background technology
The application of biochip technology brings a revolution for fields such as the diagnosis of disease and treatment, new drug development, molecular biology, judicial expertise, food hygiene and environmental monitorings on the one hand, the mankind that appear as of biochip provide the strong technological means that can carry out high speed, parallel acquisition and analysis to individual biological information, meanwhile, chemiluminescence class biochip technology has also obtained continuous development.Fa Zhan all chemiluminescence biochip technologies so far, be to have highly sensitive chemical luminescent detecting technology to combine with the immune response of high specific, the detection analytical technology that is used for various antigens, haptens, antibody, hormone, enzyme, fatty acid, vitamin and medicine etc. is a up-to-date immunoassay of exempting to analyze, growing up after fluoroimmunoassay and the time resolved fluoro-immunoassay continue radioimmunology analysis, enzyme.But chemiluminescence analyzing biochips technology also has the following disadvantages at present:
(1) no professional automatic information fetch equipment, reading of its biological information need utilize the fluorescent scanning instrument, but need do manual adjustment to the light path of fluorescent scanning instrument the inside, can be applied to the scanning of the biochip of chemiluminescence class.
(2) adopt the scanner outside to add the pattern of luminescent solution, sweep velocity is slow since the time stickiness effect, the scanning errors between the Kong Yukong is difficult to avoid.
The utility model content
The applicant provides a kind of full-automatic chemical luminous organism chip scanner at above-mentioned problem, realizes the robotization that chemiluminescence biochip information reads, and improves sweep velocity, reduces scanning errors, increases work efficiency.
In order to solve the problems of the technologies described above, the utility model adopts following technical scheme:
A kind of full-automatic chemical luminous organism chip scanner comprises:
Shell, shell are the inner closure casing that forms the darkroom, and the middle part in the shell is provided with working plate, and the shell front portion is provided with turnover door and operation interface;
Kinetic control system is installed on the described working plate, comprises X-axis drive unit and Y-axis drive unit, is used for movement and the location of biochip;
The support plate platform is installed on the kinetic control system, by kinetic control system control do X axis and Y-axis to motion, the space of ccontaining biochip grillage is arranged on the support plate platform;
Signals collecting and disposal system, signals collecting and disposal system are fixedly mounted under the described working plate, comprise camera lens and ccd image sensor, to the tested biochip biological information on the support plate platform read, transmit, preservation, data processing, data analysis, data storage;
The liquid cyclic control system comprises liquid-adding device and washes needle device, and liquid-adding device is that tested biochip adds luminescent solution on the support plate platform, washes needle device the liquid feeding pin of liquid-adding device is cleaned;
The environmental monitoring control system, comprise temperature sensor, light leak degree sensor and water leakage monitoring module, temperature sensor, light leak degree sensor detect in real time to the light leak degree in darkroom in the shell and the carrying out of temperature, and whether the water leakage monitoring module detects washes needle device and leak;
The support plate information identification system is installed on the described working plate, comprises code reader, support plate identification optoelectronic switch, RFID antenna and RFID module for reading and writing, judges whether the biochip grillage is placed on the support plate platform, and reads the biological information of biochip grillage;
The control core comprises scanner controller and computer system, connects also Collaborative Control kinetic control system, signals collecting and disposal system, liquid cyclic control system, environmental monitoring control system, support plate information identification system.
Wherein, X-axis drive unit and Y-axis drive unit are synchronous drive mechanism, the X-axis drive unit comprises X-axis electric system and the X-axis conveyer belt system that is installed on the working plate, the X-axis electric system comprises X-axis motor and X-axis scrambler, the X-axis conveyer belt system comprises X-axis driving wheel, X-axis engaged wheel and X-axis belt, and the X-axis driving wheel is connected on the X-axis motor;
Described Y-axis drive unit comprises Y-axis mount pad, X-axis guiding rail, Y-axis guiding rail, y-axis motor system and Y-axis conveyer belt system, the y-axis motor system comprises y-axis motor and Y-axis scrambler, the Y-axis conveyer belt system comprises Y-axis driving wheel, Y-axis engaged wheel and Y-axis belt, X-axis driving wheel; The support plate platform slides at the Y-axis guiding rail by support plate platform contiguous block, simultaneously support plate platform contiguous block is connected to the Y-axis belt by the Y-axis piece that is in transmission connection, the Y-axis guiding rail is fixedly mounted on the Y-axis mount pad, the Y-axis mount pad slides on the X-axis guiding rail, simultaneously the Y-axis mount pad is connected on the X-axis belt by the X-axis piece that is in transmission connection, on the X-axis guiding rail fixed installation working plate.
One side of X-axis drive unit is provided with the X-axis belt stretcher.
X-axis drive unit and Y-axis drive unit are respectively equipped with X-axis optoelectronic switch and Y-axis optoelectronic switch as origin switch separately.
Liquid-adding device is two cover A, B, and every cover liquid-adding device comprises luminescent solution bottle and level detection module, and the luminescent solution bottle is connected with the liquid feeding pin with syringe pump successively by pipeline; Described liquid feeding pin is installed on the whirligig, and whirligig is installed on the working plate, and the rotating range of liquid feeding pin is at least to be washed between needle device and the support plate platform.
One side of turning axle is provided with optoelectronic switch and is liquid feeding pin location.
Washing needle device comprises bottle for handling liquid toilet or cosmetic substance, waste liquid bottle, peristaltic pump, flow sensor and washes needle tray, and wash needle tray and be fixed on the working plate, described bottle for handling liquid toilet or cosmetic substance connects peristaltic pump, flow sensor successively, washes needle tray and waste liquid bottle by pipeline.
The full-automatic chemical luminous organism chip scanner that the utility model provides is realized the robotization that chemiluminescence biochip information reads, and improves sweep velocity, reduces scanning errors, increases work efficiency system's operational reliability height.
Description of drawings
Fig. 1 is surface structure synoptic diagram of the present utility model;
Fig. 2 is inner structure synoptic diagram of the present utility model;
Fig. 3 is the structural representation of signals collecting and disposal system;
Fig. 4 is the structural representation of the liquid-adding device of liquid cyclic control system;
Fig. 5 is the structural representation of washing needle device of liquid cyclic control system.
Embodiment
Below in conjunction with accompanying drawing embodiment of the present utility model is described in further detail.
Shown in Fig. 1 ~ 5, the utility model comprises shell 85, kinetic control system, support plate platform 20, signals collecting and disposal system, liquid cyclic control system, environmental monitoring control system and control core.Shell 85 is the inner closure casing that forms the darkroom, middle part in the shell 85 is provided with working plate 21, shell 85 front portions are provided with turnover door 81, operation interface comprises power light 82, status indicator lamp 84 and action button 83, power light 82 is used to indicate instrument and whether is in power-up state, and status indicator lamp 84 is used to indicate the residing different running statuses of current instrument.
As shown in Figure 2, kinetic control system is installed on the working plate 21, comprise X-axis drive unit 100 and Y-axis drive unit 200, the movement and the location that are used for biochip, support plate platform 20 connects kinetic control system, support plate platform 20 is provided with the space of ccontaining biochip grillage, with kinetic control system do X axis and Y-axis to motion, can locate on the support plate platform 20 microslide, 96 microwell plates, 384 microwell plates, 48 microwell plates etc. are set.
Described Y-axis drive unit comprises Y-axis mount pad 18, X-axis guiding rail 16, Y-axis guiding rail 17, y-axis motor system and Y-axis conveyer belt system, the y-axis motor system comprises y-axis motor 10 and Y-axis scrambler 22, the Y-axis conveyer belt system comprises Y-axis driving wheel 12, Y-axis engaged wheel 14 and Y-axis belt 13, X-axis driving wheel 3; Support plate platform 20 slides at Y-axis guiding rail 17 by support plate platform contiguous block 19, simultaneously support plate platform contiguous block 19 is connected to Y-axis belt 13 by the Y-axis piece 25 that is in transmission connection, Y-axis guiding rail 17 is fixedly mounted on the Y-axis mount pad 18, Y-axis mount pad 18 is 16 slips on the X-axis guiding rail, simultaneously Y-axis mount pad 18 is connected on the X-axis belt 4 by the X-axis piece 24 that is in transmission connection, on the X-axis guiding rail 16 fixed installation working plates 21.
X-axis optoelectronic switch 9 is fixed on the working plate 21 as the origin switch on the X-direction, and Y-axis optoelectronic switch 15 is fixed on the Y-axis mount pad 18 as the origin switch on the Y direction.
As shown in Figure 3, signals collecting and disposal system comprise camera lens 33 and ccd image sensor 34, camera lens 33 is fixedly mounted on working plate 21 times by camera lens fixed head 32, ccd image sensor 34 is fixedly mounted on working plate 21 times by CCD fixed block 35, ccd image sensor 34 connects computing machine by lead, to tested biochip biological information read, transmit, preservation, data processing, data analysis, data storage.
The liquid cyclic control system comprises liquid-adding device and washes needle device, for tested biochip adds luminescent solution and the liquid feeding pin is washed pin.As shown in Figure 4, liquid-adding device is two cover A, B, the luminescent solution bottle A57 of liquid-adding device A is placed on the load plate A58, level detection modules A 59 is surveyed the liquid level of luminescent solution bottle A57, luminescent solution bottle A57 connects syringe pump A60 and liquid feeding pin A65 by pipeline, and luminescent solution bottle B54, the syringe pump B52 of liquid-adding device B, level detection module B55, load plate B53, liquid feeding pin B66 connect with the same manner;
Liquid feeding pin A65 and liquid feeding pin B66 are installed on the whirligig by liquid feeding pin mounting blocks 64; The rotating range of liquid feeding pin is for washing between needle device and the support plate platform 20.
Rotary device structure is, turning axle 63 is rotatably installed on the working plate 21, the upper end of turning axle 63 is provided with pivot arm 26, the lower end connection reducer 61 of turning axle 63 and shaft rotating motor 56, liquid feeding pin A65 and liquid feeding pin B66 are fixedly mounted on the front end of pivot arm 26 by mounting blocks 64, and liquid feeding pin A65 and liquid feeding pin B66 do the rotation round setting movement with turning axle 63; One side of turning axle 63 is provided with turning axle optoelectronic switch 62, shaft rotating motor 56 with turning axle optoelectronic switch 62 as initial point, for liquid feeding pin A65 and liquid feeding pin B66 do positioning control.
As shown in Figure 5, washing needle device comprises bottle for handling liquid toilet or cosmetic substance 41, waste liquid bottle 42, peristaltic pump 43, flow sensor 44 and washes needle tray 45, bottle for handling liquid toilet or cosmetic substance 41 and waste liquid bottle 42 are placed on the scanner outside, bottle for handling liquid toilet or cosmetic substance 41 connects peristaltic pump 43, flow sensor 44 successively, washes needle tray 45 and waste liquid bottle 42 by pipeline, washes needle tray 45 and is fixed on the working plate 21.
As shown in Figure 2, the environmental monitoring control system comprises temperature sensor 76, light leak degree sensor 77 and water leakage monitoring module 78, temperature sensor 76 and light leak degree sensor 77 are fixed on the working plate 21, water leakage monitoring module 78 is fixed on washes on the needle tray 45, respectively the light leak degree in darkroom in the shell and the carrying out of temperature are detected in real time, and detect and to wash needle device and whether leak.The environmental monitoring control system judges abnormal conditions in the variation that scanning process can read environment according to biological information, and reports to the police.The support plate information identification system comprises code reader 71, support plate identification optoelectronic switch 72, RFID antenna 73 and RFID module for reading and writing 74, code reader 71 is fixed on the working plate 21 by code reader fixed block 75, RFID module for reading and writing 74 is fixed on the lower shoe 79 of shell 85, RFID antenna 73 is fixed on the working plate 21, RFID module for reading and writing 74 connects RFID antenna 73 by lead, the support plate information identification system is for detection of whether placing biochip on the support plate platform 20, and utilize code reader to read the biological information of biochip grillage, utilize support plate identification optoelectronic switch 72 to judge whether the biochip grillage is placed on the support plate platform 20 simultaneously.
The control core comprises scanner controller and computer system, connect also Collaborative Control kinetic control system, signals collecting and disposal system, liquid cyclic control system, environmental monitoring control system, support plate information identification system, realize chemiluminescence class biochip the biological information autoscan, read data, and analyze data automatically, obtain a result.
In use, put into the biochip that need carry out data read and analyze after, the clicking operation button is finished liquid feeding, data read, data transmission, data analysis automatically, and draws judged result automatically.When operation, press the operation button 83, the X-axis drive unit 100 of kinetic control system and Y-axis drive unit 200 are done the horizontal location motion, support plate platform 20 is sent stop position to door from the turnover door 81 of scanner, this moment, the user can be placed on tested biochip grillage and the biochip on the grillage on the support plate platform 20, press the operation button 83 again, kinetic control system moves to the origin position of kinematic system with support plate platform 20, and pass in and out door 81 and close automatically this moment; Press scanning operation button at the software interface of computer, scanner work begins, and the support plate platform 20 of scanner is done setting movement, and first hole that needs on the biochip grillage to scan is positioned the scanning position of signals collecting and disposal system; Shaft rotating motor 56 drive location liquid feeding pin A65 and liquid feeding pin B66 open peristaltic pump 43 in the position of washing needle tray 45, open syringe pump A60, syringe pump B52 simultaneously, make whole liquid road be in recurrent state; After washing pin time is up, peristaltic pump 43 is closed, and syringe pump A60, syringe pump B52 close, and shaft rotating motor 56 transmissions location liquid feeding pin A65 and liquid feeding pin B66 are in the scanning position of signals collecting and disposal system; Add luminescent solution through syringe pump, signals collecting and disposal system are started working after adding, and take pictures and read, and data in real time is sent to the computer system of control core; After transmission is finished, kinetic control system is positioned second hole that the support plate platform needs on the biochip grillage about in the of 20 to scan for scanning position, repeat above-mentioned action, the scanner uni data of finishing second hole transmit, by that analogy, scanned whole positions, biochip hole, kinetic control system returns initial point, the end of scan.
Claims (7)
1. full-automatic chemical luminous organism chip scanner comprises:
Shell, shell are the inner closure casing that forms the darkroom, and the middle part in the shell is provided with working plate, and the shell front portion is provided with turnover door and operation interface;
Kinetic control system is installed on the described working plate, comprises X-axis drive unit and Y-axis drive unit, is used for movement and the location of biochip;
The support plate platform is installed on the kinetic control system, by kinetic control system control do X axis and Y-axis to motion, the space of ccontaining biochip grillage is arranged on the support plate platform;
Signals collecting and disposal system, signals collecting and disposal system are fixedly mounted under the described working plate, comprise camera lens and ccd image sensor, to the tested biochip biological information on the support plate platform read, transmit, preservation, data processing, data analysis, data storage;
The liquid cyclic control system comprises liquid-adding device and washes needle device, and liquid-adding device is that tested biochip adds luminescent solution on the support plate platform, washes needle device the liquid feeding pin of liquid-adding device is cleaned;
The environmental monitoring control system, comprise temperature sensor, light leak degree sensor and water leakage monitoring module, temperature sensor, light leak degree sensor detect in real time to the light leak degree in darkroom in the shell and the carrying out of temperature, and whether the water leakage monitoring module detects washes needle device and leak;
The support plate information identification system is installed on the described working plate, comprises code reader, support plate identification optoelectronic switch, RFID antenna and RFID module for reading and writing, judges whether the biochip grillage is placed on the support plate platform, and reads the biological information of biochip grillage;
The control core comprises scanner controller and computer system, connects also Collaborative Control kinetic control system, signals collecting and disposal system, liquid cyclic control system, environmental monitoring control system, support plate information identification system.
2. full-automatic chemical luminous organism chip scanner according to claim 1, it is characterized in that: described X-axis drive unit and Y-axis drive unit are synchronous drive mechanism, the X-axis drive unit comprises X-axis electric system and the X-axis conveyer belt system that is installed on the working plate, the X-axis electric system comprises X-axis motor and X-axis scrambler, the X-axis conveyer belt system comprises X-axis driving wheel, X-axis engaged wheel and X-axis belt, and the X-axis driving wheel is connected on the X-axis motor;
Described Y-axis drive unit comprises Y-axis mount pad, X-axis guiding rail, Y-axis guiding rail, y-axis motor system and Y-axis conveyer belt system, the y-axis motor system comprises y-axis motor and Y-axis scrambler, the Y-axis conveyer belt system comprises Y-axis driving wheel, Y-axis engaged wheel and Y-axis belt, X-axis driving wheel; The support plate platform slides at the Y-axis guiding rail by support plate platform contiguous block, simultaneously support plate platform contiguous block is connected to the Y-axis belt by the Y-axis piece that is in transmission connection, the Y-axis guiding rail is fixedly mounted on the Y-axis mount pad, the Y-axis mount pad slides on the X-axis guiding rail, simultaneously the Y-axis mount pad is connected on the X-axis belt by the X-axis piece that is in transmission connection, on the X-axis guiding rail fixed installation working plate.
3. full-automatic chemical luminous organism chip scanner according to claim 2, it is characterized in that: a side of described X-axis drive unit is provided with the X-axis belt stretcher.
4. according to claim 2 or 3 described full-automatic chemical luminous organism chip scanners, it is characterized in that: described X-axis drive unit and Y-axis drive unit are respectively equipped with X-axis optoelectronic switch and Y-axis optoelectronic switch as origin switch separately.
5. full-automatic chemical luminous organism chip scanner according to claim 1, it is characterized in that: described liquid-adding device is two cover A, B, every cover liquid-adding device comprises luminescent solution bottle and level detection module, and the luminescent solution bottle is connected with the liquid feeding pin with syringe pump successively by pipeline; Described liquid feeding pin is installed on the whirligig, and whirligig is installed on the working plate, and the rotating range of liquid feeding pin is at least to be washed between needle device and the support plate platform.
6. full-automatic chemical luminous organism chip scanner according to claim 5 is characterized in that: it is liquid feeding pin location that a side of described turning axle is provided with optoelectronic switch.
7. full-automatic chemical luminous organism chip scanner according to claim 1 or 5, it is characterized in that: the described needle device of washing comprises bottle for handling liquid toilet or cosmetic substance, waste liquid bottle, peristaltic pump, flow sensor and washes needle tray, wash needle tray and be fixed on the working plate, described bottle for handling liquid toilet or cosmetic substance connects peristaltic pump, flow sensor successively, washes needle tray and waste liquid bottle by pipeline.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320249167 CN203232038U (en) | 2013-05-10 | 2013-05-10 | Full automatic chemiluminiscence biochip scanner |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201320249167 CN203232038U (en) | 2013-05-10 | 2013-05-10 | Full automatic chemiluminiscence biochip scanner |
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| CN 201320249167 Expired - Lifetime CN203232038U (en) | 2013-05-10 | 2013-05-10 | Full automatic chemiluminiscence biochip scanner |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104007270A (en) * | 2014-03-20 | 2014-08-27 | 欧蒙医学诊断（中国）有限公司 | Biological detection analysis apparatus |
| CN104833812A (en) * | 2015-05-12 | 2015-08-12 | 天津微纳芯科技有限公司 | Portable full-automatic biochemical analysis device |
| CN104865399A (en) * | 2015-05-15 | 2015-08-26 | 武汉明德生物科技股份有限公司 | Anti-stuck quantitative immunity analyzer convenient to clean |
| CN109735446A (en) * | 2019-02-26 | 2019-05-10 | 无锡圣诺亚科技有限公司 | Urease methods helicobacter pylori intelligent diagnosing instrument |
-
2013
- 2013-05-10 CN CN 201320249167 patent/CN203232038U/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104007270A (en) * | 2014-03-20 | 2014-08-27 | 欧蒙医学诊断（中国）有限公司 | Biological detection analysis apparatus |
| CN104833812A (en) * | 2015-05-12 | 2015-08-12 | 天津微纳芯科技有限公司 | Portable full-automatic biochemical analysis device |
| CN104833812B (en) * | 2015-05-12 | 2016-05-11 | 天津微纳芯科技有限公司 | Portable type full-automatic biochemical analyser |
| WO2016180087A1 (en) * | 2015-05-12 | 2016-11-17 | 天津微纳芯科技有限公司 | Portable full-automatic biochemical analysis device |
| CN104865399A (en) * | 2015-05-15 | 2015-08-26 | 武汉明德生物科技股份有限公司 | Anti-stuck quantitative immunity analyzer convenient to clean |
| CN109735446A (en) * | 2019-02-26 | 2019-05-10 | 无锡圣诺亚科技有限公司 | Urease methods helicobacter pylori intelligent diagnosing instrument |
| CN109735446B (en) * | 2019-02-26 | 2023-11-14 | 无锡华纳医疗科技有限公司 | Intelligent diagnosis instrument for helicobacter pylori by urease |
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