CN107255729A - A kind of automatic clinical chemistry analyzer and its method of work - Google Patents
A kind of automatic clinical chemistry analyzer and its method of work Download PDFInfo
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- CN107255729A CN107255729A CN201710468719.1A CN201710468719A CN107255729A CN 107255729 A CN107255729 A CN 107255729A CN 201710468719 A CN201710468719 A CN 201710468719A CN 107255729 A CN107255729 A CN 107255729A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
- G01N35/00663—Quality control of consumables
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
- G01N35/00663—Quality control of consumables
- G01N2035/00673—Quality control of consumables of reagents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N2035/00891—Displaying information to the operator
- G01N2035/009—Displaying information to the operator alarms, e.g. audible
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Abstract
The invention discloses a kind of automatic clinical chemistry analyzer, including microcontroller, microcontroller is connected with reagent filling and pipette mechanism, sample filling and pipette mechanism, wiper mechanism, rabbling mechanism, optical module and reaction tray and reaction cup；Microcontroller is additionally provided with interactive interface；Microcontroller is connected with host computer by interactive interface；The input of host computer is connected with keyboard and mouse, and its output end is connected with display and printer.The present invention improves operating efficiency and the adaptability to increasingly increased inspection workload, is easy to the reasonable utilization of medical resource by using full automatic Biochemical Analyzer；Due to using the analyzer, it is to avoid many units are examined respectively, and reduce the quantity of operating personnel, so not only reduce space occupancy rate, and also help the cost that uses manpower and material resources sparingly；By setting wiper mechanism, be conducive to the cleaning operation to reaction cup after being completed, save manpower and workload.
Description
Technical field
The invention belongs to medical inspection technique with the apparatus field, more particularly to a kind of automatic clinical chemistry analyzer and its work
Method.
Background technology
With the continuous improvement of people's living standards, the concern and investment degree for health also increase therewith, to medical treatment guarantor
Strong demand also increasingly increases.The workload of hospital constantly expands, and clinical laboratory has begun to face the sample needs of more patients
Detection.By taking biochemistry detection as an example, the daily detection limit of City Hospitals averagely has increased to more than 4000 tests, even more many, after
It is continuous to update or expand the disposal ability for examining equipment, if detected respectively with many units, not only need several operating personnel, day
Normal workload is very big, maintenance trouble, and accuracy of detection error is there is between distinct device, and quality is difficult to control, it more difficult to done
To standardization and unitized.Simultaneously unavoidably there is the overlapping investment of hardware and software in multiple devices, each not phase of consumable material
Together, the increase of day-to-day operation cost is caused.Full automatic biochemical apparatus by be solve above-mentioned technical problem fine direction.
The content of the invention
It is an object of the invention to provide a kind of automatic clinical chemistry analyzer and its method of work.
The purpose of the present invention is achieved through the following technical solutions：
The present invention is a kind of automatic clinical chemistry analyzer, including microcontroller, the input of the microcontroller is connected with
Temperature Humidity Sensor, level sensor and camera, the output end of microcontroller are connected with reagent filling and pipette mechanism, sample
Filling and pipette mechanism, wiper mechanism, rabbling mechanism, reaction tray and reaction cup, alarm module and pollution discharge mechanism；Microcontroller is also
Optical module and interactive interface, microcontroller and optical module interactive correspondence are connected with, microcontroller is connected by interactive interface
There is host computer；The input of host computer is connected with keyboard and mouse, and the output end of host computer is connected with display and printer；Institute
State filling and pipette action that reagent filling and pipette mechanism are used to perform reagent；The sample filling is used to hold with pipette mechanism
The filling of row sample is acted with pipette, and the wiper mechanism is used to perform the cleaning action to reaction cup, and the rabbling mechanism is used
Reagent and sample in reaction cup are stirred operation, and the optical module is used to enter the absorbance of solution in reaction cup
Row is tested and is back to microcontroller, and the microcontroller is stored as phase after being analyzed and processed to absorbance test data
Test data is answered, corresponding test data is reached host computer by the microcontroller by interactive interface.
Further, the keyboard and mouse are used to inputting and inquiring about corresponding test data, the display and printer
For exporting corresponding test data.
Further, the interactive interface is RS485 EBIs, and microcontroller is single-chip microcomputer, and optical module includes light
Source, grating and photometer.
Further, the grating is without difference concave surface etched grating.
Further, the Temperature Humidity Sensor is used to detect that the temperature-humidity signal in Biochemical Analyzer is then sent it to
Microcontroller, microcontroller reaches host computer after being analyzed and processed to it by interactive interface, is then shown in real time by display
Warm and humid angle value；When the Threshold of Temperature And Humidity that humiture is set beyond microcontroller, alarm is carried out with regard to control alarm module and carried
Show.
Further, the level sensor is used for the liquid level signal detected in reflection cup and sends it to microcontroller,
Microcontroller carries out controlling reagent filling with pipette mechanism, sample filling with inhaling after analysis judgement respectively to the liquid level signal received
Measuring mechanism, then controls the adding amount of reagent and sample respectively.
Further, the camera is used to gather the real scene image information in biochemical instruments reative cell, and sends it to micro-
Controller, is then analyzed and processed by microcontroller to the real scene image information received, and the image information after processing is again through handing over
Mutual connection oral instructions to host computer, PC control display shows real scene image information in reative cell in real time.
Further, the pollution discharge mechanism cleans the sewage progress sewage treatment of reaction cup to wiper mechanism.
A kind of method of work of automatic clinical chemistry analyzer, including step in detail below：
Step one, start is checked, confirmatory sample pin, reagent pin confirm the cleaning agent in cleaning mechanism without dirty or bending
Whether sufficient, sample pipette mechanism and reagent pipette mechanism are without leakage, sample filling mechanism and reagent filling mechanism bubble-free；Its
In, sample pin is in sample filling and pipette mechanism 3, and reagent pin is arranged in reagent filling and pipette mechanism；
Step 2, microprocessor control sample filling sucks sample with pipette mechanism, and sample is added into reaction cup；Then
Microcontroller controls reagent filling to suck reagent with pipette mechanism again, and reagent is added in corresponding reaction cup；
Step 3, starts reaction tray, drives reaction cup rotation, and rabbling mechanism is stirred to the solution in reaction cup, instead
It is 18 seconds/circle that rotating speed, which should be coiled, in reaction tray rotary course, and the solution in reaction cup is per crosscutting primary source, photometric determination one
Secondary absorbance, light-metering of instrument record, instrument use full response process Exposure Metering, in the reflecting time of setting, not between
Solution absorbance in reaction cup is determined disconnectedly；
Step 4, microcontroller obtains absorbance detection data by optical module, after being analyzed and processed to it, passes through interaction
Interface is uploaded to host computer, then respectively by display and printer with corresponding form output detection data；
Step 5, after test terminates, microprocessor control wiper mechanism is cleaned to reaction cup.
The invention has the advantages that：
The present invention improves operating efficiency and to increasingly increased inspection man by using full automatic Biochemical Analyzer
The adaptability that work is measured, is easy to the reasonable utilization of medical resource；Due to using the analyzer, it is to avoid many units are examined respectively
Test, and reduce the quantity of operating personnel, so not only reduce space occupancy rate, and also help and use manpower and material resources sparingly into
This；By setting sample filling and pipette mechanism, reagent filling and pipette mechanism, it is easy to automatic to sample, reagent progress respectively
Filling and pipette operation, it is to avoid human hand directly contact causes the pollution of sample and reagent；By setting rabbling mechanism and controllable rotation
The reaction tray turned, is conducive to being stirred the mixed solution being made up of sample and reagent in reaction cup, to accelerate reaction speed
With the sufficient degree of reaction；By setting wiper mechanism, be conducive to the cleaning operation to reaction cup after being completed, save manpower
And workload；By pollution discharge mechanism, it is easy to the sewage after discharge wiper mechanism is cleaned to reaction tray in time, prevents breed bacteria micro-
It is biological；By setting Temperature Humidity Sensor, it is easy to monitor reaction chamber temperature；By setting camera, it is easy to supervise reaction in real time
Indoor real time status；By setting level sensor, it is easy to detect the liquid level in reaction cup in real time, then by micro-
Controller controls sample filling and pipette mechanism, reagent filling and pipette mechanism respectively, be conducive to more accurately controlling sample and
The adding amount of reagent.
Certainly, any product for implementing the present invention it is not absolutely required to while reaching all the above advantage.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, used required for being described below to embodiment
Accompanying drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for ability
For the those of ordinary skill of domain, on the premise of not paying creative work, it can also be obtained according to these accompanying drawings other attached
Figure.
Fig. 1 is a kind of composition frame chart of automatic clinical chemistry analyzer of the present invention.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is all other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
Refer to shown in Fig. 1, the present invention is a kind of automatic clinical chemistry analyzer, including microcontroller 1, microcontroller 1
Input is connected with Temperature Humidity Sensor 14, level sensor 15 and camera 18, and the output end of microcontroller 1 is connected with reagent
Filling and pipette mechanism 2, sample filling and pipette mechanism 3, wiper mechanism 4, rabbling mechanism 5, reaction tray and reaction cup 7, alarm
Module 16 and pollution discharge mechanism 17；Microcontroller 1 is also associated with optical module 6 and interactive interface 8, microcontroller 1 and optical module
Interactive correspondence, interactive interface 8 is RS485 EBIs；Microcontroller 1 is connected with host computer 9 by interactive interface 8；Host computer 9
Input be connected with keyboard 12 and mouse 13, the output end of host computer 9 is connected with display 10 and printer 11.
Wherein, microcontroller 1 is single-chip microcomputer, and reagent filling is used to perform under the control of microcontroller 1 with pipette mechanism 2
The filling of reagent is acted with pipette, filling of the sample filling with pipette mechanism 3 for performing sample under the control of microcontroller 1
Acted with pipette, wiper mechanism 4 is used to perform the cleaning action to reaction cup under the control of microcontroller 1, and rabbling mechanism 5 is used
Operation is stirred to the reagent and sample in reaction cup in being performed under the control in microcontroller 1, the optical module 6 is used for
Performed under the control of microcontroller 1 and the absorbance of solution in reaction cup is tested and microcontroller 1, the micro-control is back to
Device 1 processed is stored as corresponding test data after being analyzed and processed to absorbance test data, optical module 6 includes light source, without phase
Corresponding test data is reached host computer 9 by poor concave surface etched grating and photometer, microcontroller 1 by interactive interface；Keyboard 12
It is used to inputting and inquiring about corresponding test data with mouse 13, display 10 and printer 11 are used to output test data.
Wherein, the temperature-humidity signal that the Temperature Humidity Sensor 14 is used to detect in Biochemical Analyzer then sends it to micro-
Controller 1, microcontroller 1 reaches host computer 9 after being analyzed and processed to it by interactive interface 8, then real-time by display 10
Show warm and humid angle value；Meanwhile, when the Threshold of Temperature And Humidity that humiture is set beyond the inside of microcontroller 1, just control alarm module
16 carry out alarm prompt, and the alarm module 16 is buzzer or audible-visual annunciator.
Wherein, level sensor 15 is used for the liquid level signal detected in reflection cup and sends it to microcontroller 1, microcontroller
The liquid level signal that 1 pair of device is received carries out controlling reagent filling and pipette mechanism 2, sample filling and pipette machine after analysis judgement respectively
Structure 3, then controls the adding amount of reagent and sample respectively；Level sensor 15 is contactless liquid level sensor, from ultrasound
Ripple liquid level sensor.
Wherein, camera 18 is used to gather the real scene image information in biochemical instruments reative cell, and sends it to microcontroller
1, then analyzed and processed by 1 pair of real scene image information received of microcontroller, the image information after processing connects through interaction again
Mouth 8 reaches host computer 9, and the control display 10 of host computer 9 shows real scene image information in reative cell, is easy to operating personnel real in real time
When observe and take corresponding measure.
Wherein, pollution discharge mechanism 17 cleans the sewage progress sewage treatment of reaction cup to wiper mechanism 4.
The method of work of the automatic clinical chemistry analyzer, including step in detail below：
Step one, start is checked, confirmatory sample pin, reagent pin confirm the cleaning agent in cleaning mechanism without dirty or bending
Whether sufficient, sample pipette mechanism and reagent pipette mechanism are without leakage, sample filling mechanism and reagent filling mechanism bubble-free；Its
In, sample pin is in sample filling and pipette mechanism 3, and reagent pin is arranged in reagent filling and pipette mechanism 2；
Step 2, the control sample filling of microcontroller 1 sucks sample with pipette mechanism 3, and sample is added into reaction cup；So
Microcontroller 1 controls reagent filling to suck reagent with pipette mechanism 2 again afterwards, and reagent is added in corresponding reaction cup；
Step 3, starts reaction tray, drives reaction cup rotation, and rabbling mechanism 5 is stirred to the solution in reaction cup, instead
It is 18 seconds/circle that rotating speed, which should be coiled, in reaction tray rotary course, and the solution in reaction cup is per crosscutting primary source, photometric determination one
Secondary absorbance, light-metering of instrument record, instrument use full response process Exposure Metering, in the reflecting time of setting, not between
Solution absorbance in reaction cup is determined disconnectedly；
Step 4, microcontroller 1 obtains absorbance detection data by optical module 6, after being analyzed and processed to it, by handing over
Mutual interface 8 is uploaded to host computer 9, then respectively by display 10 and printer 11 with corresponding form output detection data；
Step 5, after test terminates, the control wiper mechanism 4 of microcontroller 1 is cleaned to reaction cup.
Finally it should be noted that present invention disclosed above preferred embodiment, which is only intended to help, illustrates the present invention.It is excellent
Embodiment is selected not have all details of detailed descriptionthe, it is only described embodiment that the invention is not limited yet.Obviously, root
According to the content of this specification, it can make many modifications and variations.This specification is chosen and specifically describes these embodiments, be in order to
The principle and practical application of the present invention is preferably explained, so that skilled artisan can be best understood by and utilize
The present invention.The invention is limited only by the claims and the full scope thereof and equivalents thereof.
Claims (9)
1. a kind of automatic clinical chemistry analyzer, it is characterised in that：Including microcontroller (1), the input of the microcontroller (1)
Temperature Humidity Sensor (14), level sensor (15) and camera (18) are connected with, the output end of microcontroller (1) is connected with examination
Agent filling and pipette mechanism (2), sample filling and pipette mechanism (3), wiper mechanism (4), rabbling mechanism (5), reaction tray and anti-
Answer cup (7), alarm module (16) and pollution discharge mechanism (17)；Microcontroller (1) is also associated with optical module (6) and interactive interface
(8), microcontroller (1) and optical module (6) interactive correspondence, microcontroller (1) are connected with host computer by interactive interface (8)
(9)；The input of host computer (9) is connected with keyboard (12) and mouse (13), and the output end of host computer (9) is connected with display
And printer (11) (10)；
The filling that the reagent filling is used to perform reagent with pipette mechanism (2) is acted with pipette；The sample filling and pipette
The filling that mechanism (3) is used to perform sample is acted with pipette, and the cleaning that the wiper mechanism (4) is used to perform to reaction cup is moved
Make, the rabbling mechanism (5) is used to be stirred the reagent and sample in reaction cup operation, and the optical module (6) is used for
Absorbance to solution in reaction cup is tested and is back to microcontroller (1), and the microcontroller (1) is to absorbance
Test data is stored as corresponding test data after being analyzed and processed, the microcontroller (1) will accordingly be surveyed by interactive interface
Examination data reach host computer (9).
2. a kind of automatic clinical chemistry analyzer according to claim 1, it is characterised in that：The keyboard (12) and mouse
(13) it is used to inputting and inquiring about corresponding test data, the display (10) and printer (11) are used to export corresponding test number
According to.
3. a kind of automatic clinical chemistry analyzer according to claim 1, it is characterised in that：The interactive interface (8) is
RS485 EBIs, microcontroller (1) is single-chip microcomputer, and optical module (6) includes light source, grating and photometer.
4. a kind of automatic clinical chemistry analyzer according to claim 3, it is characterised in that：The grating is without difference concave surface
Etched grating.
5. a kind of automatic clinical chemistry analyzer according to claim 1, it is characterised in that：The Temperature Humidity Sensor (14)
For detecting that the temperature-humidity signal in Biochemical Analyzer then sends it to microcontroller (1), microcontroller (1) analyzes it place
Host computer (9) is reached by interactive interface (8) after reason, warm and humid angle value is then shown by display (10) in real time；Work as humiture
During the Threshold of Temperature And Humidity set inside microcontroller (1), alarm prompt is carried out with regard to control alarm module (16).
6. a kind of automatic clinical chemistry analyzer according to claim 1, it is characterised in that：The level sensor (15) is used
In detecting the liquid level signal reflected in cup and sending it to microcontroller (1), microcontroller (1) is carried out to the liquid level signal received
Analysis controls reagent filling and pipette mechanism (2), sample filling and pipette mechanism (3) respectively after judging, then control examination respectively
Agent and the adding amount of sample.
7. a kind of automatic clinical chemistry analyzer according to claim 1, it is characterised in that：The camera (18) is used to adopt
Collect the real scene image information in biochemical instruments reative cell, and send it to microcontroller (1), then by microcontroller (1) to receiving
Real scene image information analyzed and processed, the image information after processing reaches host computer (9) through interactive interface (8) again, upper
Machine (9) control display (10) shows real scene image information in reative cell in real time.
8. a kind of automatic clinical chemistry analyzer according to claim 1, it is characterised in that：The pollution discharge mechanism (17) is to clear
The sewage of washing machine structure (4) cleaning reaction cup carries out sewage treatment.
9. a kind of method of work of automatic clinical chemistry analyzer as claimed in claim 1, it is characterised in that：Including in detail below
Step：
Step one, start check, confirmatory sample pin, reagent pin without it is dirty or bending, confirm cleaning mechanism in cleaning agent whether
Abundance, sample pipette mechanism and reagent pipette mechanism are without leakage, sample filling mechanism and reagent filling mechanism bubble-free；Wherein,
Sample pin is in sample filling and pipette mechanism (3), and reagent pin is arranged in reagent filling and pipette mechanism (2)；
Step 2, microcontroller (1) control sample filling sucks sample with pipette mechanism (3), and sample is added into reaction cup；So
Microcontroller (1) controls reagent filling to suck reagent with pipette mechanism (2) again afterwards, and reagent is added in corresponding reaction cup；
Step 3, starts reaction tray, drives reaction cup rotation, and rabbling mechanism (5) is stirred to the solution in reaction cup, is reacted
Disk rotating speed is 18 seconds/circle, in reaction tray rotary course, and the solution in reaction cup is per crosscutting primary source, and photometric determination is once
Absorbance, light-metering of instrument record, instrument uses full response process Exposure Metering, in the reflecting time of setting, uninterruptedly
Ground determines solution absorbance in reaction cup；
Step 4, microcontroller (1) obtains absorbance detection data by optical module (6), after being analyzed and processed to it, by handing over
Mutual interface (8) is uploaded to host computer (9), is then exported and detected in corresponding form by display (10) and printer (11) respectively
Data；
Step 5, after test terminates, microcontroller (1) control wiper mechanism (4) is cleaned to reaction cup.
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| CN110320167A (en) * | 2018-03-29 | 2019-10-11 | 日本株式会社日立高新技术科学 | The denier analysis and diagnosis method of atom extinction photometer and atom extinction photometer |
| CN111767961A (en) * | 2020-07-02 | 2020-10-13 | 宁波杜比医疗科技有限公司 | Biochemical analysis detection system and detection method thereof |
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