Background technology
The specific protein that colloidal gold immunochromatographimethod method is detected in pathogen or some clinical samples is that one kind is widely used
Quick determination method, this method only needs a step to be loaded, just can determine that result, and other technologies have compared in 5-10 minutes
Come, the advantage such as have simple, efficient, easy to carry, stable reagent, false positive rate low can effectively solve what is faced in practice
It is difficult.But deposited really in the POCT in clinic diagnosis, especially to grow up in recent years (real-time test by bed) technology is applied
In problems:1. needing special messenger's manual operations experiment overall process, all implementing today of automation, hospital in each scientific domain
Also efficiency is being improved as far as possible, attrition using self-reacting device, it is necessary to replace manual operations, especially obstetrics POCT detections as far as possible
Method.In obstetrics' outpatient service, the index-FFN detection doctors assessed for premature delivery risk of pregnant women need quickly to obtain detection knot
Fruit, in order to give pregnant woman's timely diagnosis and treatment plan, but during outpatient service, without special messenger operate it is such detect, doctor can not alone one
People spends 10 minutes to do such detection, so after can only sampling, it is desirable to which sampling pipe is sent to the delivery room of inpatient department by pregnant woman
After being detected by special messenger, then testing result is fetched and gives doctor, so not only bothersome, arduously, and pregnant woman in outpatient service and is in hospital
Hurried back and forth back and forth between portion, once occur surprisingly, doctor-patient dispute may being caused.Therefore, had a strong impact on that doctor carries out this inspection
The convenience of survey, but FFN is important indicator of the ministry of Health of China on suggesting detection in pregnant and lying-in women's premature labor administrative standard;2. examine
Survey sensitivity is not high, significantly limit the technology further applying in clinical examination work.Collaurum detection side at present
Method also mainly carries out interpretation by naked eyes to result, improves detection sensitivity by necessary instrument, realizes the skill of half-quantitative detection
Art application is not extensive.
Utility model content
The technical problems to be solved in the utility model is:A kind of collection sample presentation, mixing, sample-adding, detection and computer is provided to sentence
Read the colloid gold test paper detector being integrated.
In order to solve the above technical problems, the utility model provides following technical scheme:
A kind of colloid gold test paper detector, including test tube adapter, vibration evenly mixing device, test paper clamping device, light source, figure
As information collecting device, image processing system and power supply.The course of work of colloid gold test paper detector is as follows:Doctor or nurse take
Sampling test tube is placed on test tube adapter after sample, test tube adapter is made up of the flexible material provided with multiple circular holes, fixed
On vibration evenly mixing device device, circular hole aperture is suitable with the external diameter of sampling pipe, and sampling pipe can be fixed in adapter;Shake
Swing evenly mixing device and be arranged on test tube adapter bottom, after adding appropriate amount of buffer solution, vibration evenly mixing device is opened, and is fully dissolved and is mixed
After even, test paper gripping apparatus grips test paper is immersed in buffer solution, and after preset time, test paper gripping apparatus grips test paper rises
To light source, image information collecting device is arranged near light source, and the optical signal that reflection receivable obtains is through image procossing system
After system processing, finally quantitative testing result is drawn by software processing.Test paper clamping device is arranged on above test tube adapter.
Preferably, colloid gold test paper detector is additionally provided with openable shading shell, with prevent instrument detection when by
The influence of dust and light.
Preferably, test tube adapter is replaceable that the test tube adapter for having different pore size is adopted with adapting to different size
Sample pipe.
Preferably, liquid-feeding tube is additionally provided with above test tube adapter, what can be quantified injects buffer solution in sampling pipe, with reality
Now real full automatic working.
In a preference of the present utility model, light source selects LED, is particularly preferred to be 540nm green light LED.
In a preference of the present utility model, image information collecting device selects face battle array CMOS.
Scheme of the prior art can be selected in image processing system, in a preference of the present utility model, selects
C8051F120 single-chip microcomputers are Master control chip.
Preferably, colloid gold test paper detector is additionally provided with output equipment and display device, and identification apparatus such as bar
Code scanner, IC-card read write line etc., facilitate doctor to use and record testing result.
In another preference of the present utility model, in addition to test paper conveyer, test paper conveyer are placed in shading
In passage, light source and image information collecting device are located above passage, when test paper is delivered to light source and figure by test paper conveyer
During as below information collecting device, automatically analyze and read data.Sampling pipe is placed on test tube after sampling and fitted by doctor or nurse
On orchestration;After adding appropriate amount of buffer solution, vibration evenly mixing device is opened, after fully dissolving and mix, the examination of test paper gripping apparatus grips
Paper is immersed in buffer solution, and after preset time, test paper clamping device clamps test paper to test paper conveyer, conveying device
Built-in light source and image information collecting device;The pipelining operation of test paper detection can so be realized.
In another preference of the present utility model, colloid gold test paper detector is provided with two chambers, respectively buffers
Liquid disposed chamber and sensing chamber;Liquid-feeding tube is provided with above buffer solution disposed chamber, the position correspondence of liquid-feeding tube is in test tube adapter pilot scale
The position of pipe, vibration evenly mixing device bottom is provided with conveyer belt, after buffer solution has been added in buffer solution disposed chamber and has vibrated mixing,
Test tube adapter equipped with test tube is delivered to sensing chamber by conveyer belt together with vibration evenly mixing device;Examination is provided with inside sensing chamber
Paper holding device, test paper can be clamped and be detected into test tube.So liquid-feeding tube and test paper clamping device can separately be set
Put, reduce the complexity of complete equipment.
The beneficial effects of the utility model are:
1. by cumbersome sample presentation, mixing, sample-adding, detection, read testing result after returning result process full automation,
Sampling pipe is placed in instrument of the present utility model by doctor after only needing sampling, and automation equipment prints after completing said process
As a result doctor is submitted to afterwards, and as soon as doctor, without spending more minutes, can obtain testing result in Consulting room, really real
Existing POCT effect;
2. carefully studying the background of colloid gold test paper quantitative measurement technology and determined both at home and abroad using what this technology was realized
On the basis of development history and the present situation of measuring analyzer, it is proposed that a kind of to gather test strips by high sensitivity optical detective technology
Image information, and the method for realizing reagent concentration quantitative analysis with reference to later image treatment technology.The application of Systems for optical inspection
Detection sensitivity can be improved, is realized to micro, trace samplings detections.The system can also improve simultaneously is visually examined in the past
The work that test and appraisal are sentenced, is avoided due to difference caused by human factor subjective judgement, and reduces the workload of staff, is improved
Operating efficiency.
Embodiment 3
Colloid gold test paper detector, including test tube adapter 1, vibration evenly mixing device 2, test paper clamping device 3, light source 4, figure
As information collecting device 5, image processing system, power supply, test paper conveyer 7, passage 8 and test paper storage device 9;Wherein light source
For 540nm green light LED, test paper clamping device 3 selects mechanical arm, and test paper conveyer 7 selects conveyer belt;Detector is provided with
Two chambers, respectively buffer solution disposed chamber and sensing chamber;Liquid-feeding tube, the position pair of liquid-feeding tube are provided with above buffer solution disposed chamber
It should vibrate the bottom of evenly mixing device 2 in the position of test tube on test tube adapter 1 and also be provided with conveyer belt, add in buffer solution disposed chamber
After adding buffer solution and vibrating mixing, conveyer belt conveys the test tube adapter 1 equipped with test tube together with vibration evenly mixing device 2
To sensing chamber;Mechanical arm is located inside sensing chamber, and mechanical arm presss from both sides test paper to conveyer belt, and face battle array CMOS and LED are arranged at logical
The top of road 8, when test paper is sent to below LED, the light that LED is sent is reflected through test paper and quilt cover battle array CMOS is received, through image
Result is obtained after processing system processing.
Display only describes principal character and main points of the present utility model above.Those skilled in the art it should be appreciated that
The utility model is not restricted to the described embodiments.On the premise of utility model point and protection domain is not departed from, this practicality is new
Type also has various change, and these changes and improvements are fallen within the range of the requires of the utility model protection.