CN104698202A - Design of microscale sample automatic-injection system of blood type analyzer - Google Patents
Design of microscale sample automatic-injection system of blood type analyzer Download PDFInfo
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- CN104698202A CN104698202A CN201310654451.2A CN201310654451A CN104698202A CN 104698202 A CN104698202 A CN 104698202A CN 201310654451 A CN201310654451 A CN 201310654451A CN 104698202 A CN104698202 A CN 104698202A
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Abstract
The invention discloses a design of a microscale sample automatic-injection system of a blood type analyzer. The design is characterized in that the system utilizes a singlechip as a control core and comprises a microscale sample feeding module, a cleaning module, a liquid level detection module, a temperature detection module, a flow monitoring module, a keyboard module and an execution mechanism, and the above modules depend on a singlechip control system. The microscale sample automatic-injection system realizes an accurate suction and discharge function, an automatic cleaning function, an automatic control function, a system detection function and an alarm function.
Description
Technical field
The present invention is the automatic sample feeding device of a blood type analytical instrument, be combine machinery, electromechanical integration equipment that electronics, automatic control technology are integrated.
Background technology
In clinical examination field, blood type analysis is necessary test item of transfusing blood, that doctor makes accurate condition-inference and selects the important evidence of blood transfusion blood group, it is very general in clinical practice, but at present, most domestic hospital also completes match inspection in use manual mode, remaining hospital also all just uses the instrument of external a few company few in number, and can know by inference according to the statistics of annual domestic transfusion volume, domestic hospitals every year will more than 500 to the demand of full-automatic blood type analytic system.Realize the production domesticization of full-automatic blood type analytical instrument device, can break external blockade on new techniques and monopolization, the full-automatic blood type analytical technology of development China oneself and industry, save foreign exchange, meet domestic demand.
The Chief technology of full-automatic blood type analytic system mainly comprises mechanical drive and location technology, movement control technology, micro sample-adding technology, level sensing technology, fluid path cleaning technique, Centrifuge Techniques, fault diagnosis technology, mechanical arm technology, embedded Control technology, bar code identification technology, the extraction of high-definition image and treatment technology, multifunctional application analysis software technology etc.
Along with the development of medical skill, blood type analysis experiment is day by day complicated, traditional craft and semi-automatic blood type analysis instrument can not meet actual requirement, thus the demand of full-automatic blood type analytical instrument device is increased greatly, trace automatic sample module is the core component of liquid-way system in full-automatic blood type analytic system, for realizing the accurate sampling of blood sample and reagent, Given this present invention devises a set of SCM Based micro liquid automatic sample-adding system.
Summary of the invention
The object of the invention is to: based on automatic control technology, sensing technology, movement control technology etc., design a kind of blood type analysis micro liquid automatic sample-adding system, it comprises micro sample-adding functional module, cleaning module, level sensing module, temperature detecting module, flow monitoring module, Keysheet module and topworks, each module all depends on single-chip computer control system, realizes accurate extraction function, automatic cleaning function, automatic control function, systems axiol-ogy function and warning function.
The autoabstract system of the present invention's design take single-chip microcomputer as control core, in conjunction with multiple sensors as liquid level sensor, temperature sensor, flow sensor and topworks comprise stepper motor, hydraulic pump, solenoid valves etc. form automatic sample control system jointly, the main function of automatic sample-adding system is exactly the accurate extraction of blood sample when realizing blood type analysis and reagent, to complete blood type analysis work, after each application of sample work completes, all need the device that blood sample is flowed through, pipeline cleans, measurement result is next time made not to be subject to this impact of measuring, simultaneously also in order to avoid cross-infection, affect blood type analysis result, therefore sample adding system comprises automatic cleaning function, for the automatic cleaning of the accurate extraction and application of sample pipeline that realize system, , sample adding system needs the control system of robotization, realize the automatic control of whole system, system is in the process of work, need real-time monitoring system cleaning fluid and waste liquid amount, this just needs system to have the function of Real-Time Monitoring, simultaneously can occur that the special statuss such as the not enough or waste liquid of cleaning fluid surplus is too much are reported to the police to system.
1, micro sample-adding functional module
Be the core component of whole automatic sample-adding system, what complete blood sample and related reagent accurately takes out setting out, mainly comprises micro sample-adding device, T-valve and sample needle.When import 1 closed by T-valve 2, open import 2 and outlet, system just can realize the accurate extraction of reagent by controlling micro sample-adding device.
2, cleaning module
In blood type analysis experiment, the sample needle of system is all Reusability, in order to avoid cross pollution, the testing result of impact experiment, before extracting blood sample so each or each application of sample end cycle time, all to clean sample needle and application of sample pipeline, distilled water and physiological saline two kinds of cleaning fluids are adopted to carry out alternately cleaning herein, adopt the mode of " distilled water-physiological saline-distilled water " successively cleaning, improve developing result, this module mainly comprises cleaning fluid and container thereof, waste fluid container, T-valve, liquid pump, Systematical control motor driven liquid pump extracts the cleaning that cleaning fluid realizes application of sample pipeline.
3, level sensing module
System, in the process of cleaning, needs the liquid level condition of Real-Time Monitoring cleaning fluid and waste liquid, once there is the situation that cleaning fluid is not enough or waste liquid is too much to need process in time, sends alerting signal simultaneously, mainly comprises pressure liquid level sensor, control single chip computer.
4, traffic monitoring module
Flow monitoring module: system is provided with flow monitoring module, the cleaning fluid flow be used for when monitoring cleaning.Because during cleaning, the too low very difficult guarantee cleaning quality of flow velocity, the devices [14] such as the too high easy damage pipeline of flow velocity.Adopt flow sensor to monitor, the place of pipeline and hydraulic pump interface can be arranged on, and by institute's measurement of discharge feedback.
5, temperature monitoring module
When blood sample and reagent react, to temperature, there is certain requirement, and before draw blood sample is analyzed, the too low blood of temperature easily solidifies, too highly then easily destroy blood sample inner structure etc., so extremes of temperature is all unsuitable for application of sample and the detection of blood sample, thus have influence on the serviceability of system, so be necessary to carry out Real-Time Monitoring to the environment temperature of system here.
Accompanying drawing explanation
Fig. 1 is the control structure block diagram of this automatic sample-adding system;
Fig. 2 is the functional schematic of this automatic sample-adding system;
Fig. 3 is the hardware configuration schematic diagram of native system.
Embodiment
Blood type analysis micro liquid automatic sample-adding system is electromechanical integrated product, relates to the knowledge in multiple field such as machinery, electronics, automatically control, needs each side to work in coordination, be only described the specific embodiment of the present invention below.
System electrification initialization.After full-automatic blood type analysis sample adding system powers on, first the initialization of completion system and the state-detection of each module, as micro liquid filling mechanism and application of sample mechanical arm etc. get back to initial zero position, wait for the operational order that control system sends and wait for blood sample information.
Specimen discerning and loading before experiment, the information of blood sample to be checked is confirmed by medical information management system, after validation of information, experimenter manually sample and load reagents in rotating disk test tube rack special, and be loaded on sample reagent rotating disk, so far complete the preparation of samples work before blood group experiment, sample adding system sends initiation command, namely start to carry out micro-quantity extraction work to sample, thus carry out blood group experiment.
Sample and reagent location, according to the sample to be checked recorded in 2. process and reagent sites information, automatic sample-adding system calculates the feeding displacement of application of sample mechanical arm, sample reagent rotating disk, and give corresponding motion controller by the motion control Parameter transfer of each mechanism, sample to be checked is positioned to sample position by sample reagent rotating disk, and application of sample mechanical arm drags sample needle and is fed to prescribed depth under liquid level.
Extraction sample.Sample needle is deeply after draw blood sample certain depth, instruction is sent by single-chip computer control system, input application of sample amount information, select application of sample function, micro liquid filling mechanism draws quantitative blood sample, and after completing, blood sample is discharged in corresponding reaction tube by control application of sample mechanical arm dragging sample needle, after release, complete an application of sample, application of sample mechanical arm drags above sample needle to waste liquid cylinder, starts to perform cleaning function.
Sample needle cleans.After 4. completing an application of sample operation, for avoiding and lower subjob cross pollution, need to clean sample needle, now single-chip computer control system sends instruction, selects cleaning function, starts cleaning:
1) during cleaning, control system is according to the amount of required cleaning fluid, and whether the amount remaining cleaning fluid in inspection instrument reaches and meet this cleaning task, if do not met, prompting staff adds required cleaning fluid in container, otherwise, carry out step 2);
2) control system controls T-valve break-make, makes water inlet lead to water delivering orifice, and control system drives the unidirectional cleaning of hydraulic pump control distilled water, and waste liquid is discharged to waste fluid container from sample needle mouth, duration of valve opening 15s;
3) single-chip computer control system controls the closedown of T-valve water inlet, and water inlet leads to water delivering orifice, and control system drives hydraulic pump to draw the unidirectional cleaning of physiological saline, and waste liquid is discharged to waste fluid container from sample needle mouth, duration of valve opening 15s;
4) again finally clean sample needle with distilled water, process is with 2);
Completing an application of sample cycle, guarantee that each operation element resets, as needed application of sample again, getting back to beginning, otherwise, system cut-off.
Claims (6)
1. blood type analytical instrument trace automatic sample-adding system design, this system take single-chip microcomputer as control core, comprise micro sample-adding functional module, cleaning module, level sensing module, temperature detecting module, flow monitoring module, Keysheet module and topworks, each module all depends on single-chip computer control system, realizes accurate extraction function, automatic cleaning function, automatic control function, systems axiol-ogy function and warning function.
2. blood type analytical instrument trace automatic sample-adding system design according to claim 1, it is characterized in that, system take single-chip microcomputer as control core, and each module all depends on single-chip computer control system.
3. blood type analytical instrument trace automatic sample-adding system design according to claim 1, it is characterized in that, described micro sample-adding functional module is the core component of whole system, completes the accurate extraction function of reagent.
4. blood type analytical instrument trace automatic sample-adding system design according to claim 1, it is characterized in that, described cleaning module realizes the automatic cleaning function of sample needle.
5. blood type analytical instrument trace automatic sample-adding system design according to claim 1, it is characterized in that, described level sensing module, temperature detecting module, flow monitoring module realize systems axiol-ogy and warning function.
6. blood type analytical instrument trace automatic sample-adding system design according to claim 1, it is characterized in that, described Keysheet module can be arranged information such as relevant application of sample information, cleaning information, flow, temperature.
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| CN201310654451.2A CN104698202A (en) | 2013-12-09 | 2013-12-09 | Design of microscale sample automatic-injection system of blood type analyzer |
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| CN201310654451.2A CN104698202A (en) | 2013-12-09 | 2013-12-09 | Design of microscale sample automatic-injection system of blood type analyzer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107255729A (en) * | 2017-06-12 | 2017-10-17 | 合肥市第二人民医院 | A kind of automatic clinical chemistry analyzer and its method of work |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107255729A (en) * | 2017-06-12 | 2017-10-17 | 合肥市第二人民医院 | A kind of automatic clinical chemistry analyzer and its method of work |
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Application publication date: 20150610 |
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