CN106771108B - Method and device for automatically acquiring thromboelastography - Google Patents
Method and device for automatically acquiring thromboelastography Download PDFInfo
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Abstract
The utility model discloses a method and a device for automatically acquiring a thromboelastography, wherein the device comprises a shell, a base, and a lifting detection platform, wherein the lifting detection platform is arranged on the shell in a relatively sliding manner through a guide rail, a passive turntable is arranged in the lifting detection platform, a liquid guide pipe extends downwards through the circle center of the passive turntable, the liquid guide pipe is opposite to the circle center of a test tube, a detection needle is fixedly arranged on the passive turntable, the detection needle is positioned on one side of the liquid guide pipe, the tail end of the detection needle extends into the test tube, the test tube is arranged in a test tube cavity, the test tube cavity is arranged on the turntable, and the turntable is fixedly arranged in the base. The utility model can obtain the coagulation forming time, the overall view of the coagulation process and the ablation time of blood clot under the action of various coagulation factors at one time by utilizing the relative rotation speed, is used for various occasions (before operation/blood transfusion) needing to measure the coagulation, can evaluate the inhibition effect of aspirin and thienopyridine drugs on blood platelets, reduces the pain of patients for blood sampling for many times, and improves the detection efficiency.
Description
Technical Field
The utility model relates to the technical field of medical detection instruments, in particular to a method and a device for automatically acquiring a thromboelastography.
Background
Thromboelastography (TEG) is an index that reflects dynamic changes in blood coagulation, and may also reflect the time of ablation of blood clots, and is a dynamic change in various factors of blood coagulation and fibrin formation processes. The traditional Chinese medicine composition is considered to have certain application value in the aspect of increasing or reducing blood coagulability, and has certain clinical significance in diagnosing uremia, myocardial infarction, thrombocytopenia, hemophilia, primary fibrinolysis and other diseases.
An existing thrombus elastic force measuring device (application number: 201310658576.2) comprises a test cup for holding a blood sample and a detection reagent; the test cup can be hung on the cup holder in a left-right swinging manner; the driving device is used for driving the test cup to swing left and right around the cup holder; the coupling piece can be coupled with the test cup after blood is coagulated and generates a coupling force for preventing the test cup from swinging, and the coupling piece is arranged on the cup holder and is positioned in a cup cavity of the test cup; and the elastic force measuring mechanism is used for obtaining the elastic force characteristics of the blood clot in the test cup by detecting the coupling force applied to the test cup, and is arranged below the test cup. The utility model utilizes the elastic force measuring mechanism arranged below the test cup to measure the resistance force applied by the test cup during swinging, so as to realize the measurement of the thrombus elastic force, but has the following defects:
by measuring the resistance received in the sector swing, the measurement of the thrombus elasticity is realized, the stability is poor, and the precision is not high enough; the existing measuring device has single function, can only measure the thromboelastography, and has low integration level and low automation degree; the constant temperature state of 37 ℃ cannot be maintained, and various blood to be measured and various coagulation starting reagents cannot be automatically added.
Disclosure of Invention
The technical task of the utility model is to provide a method and a device for automatically acquiring a thromboelastography.
The technical task of the present utility model is achieved in the following manner,
the utility model provides an automatic acquire device of thrombus elastography, including casing and base, the top of casing is equipped with operating panel, operating panel's below is equipped with the lift and detects the platform, lift detects the platform and passes through the guide rail and install on the casing with sliding relatively, lift detects platform internally mounted has passive carousel, the centre of a circle downwardly extending of passive carousel is run through to the catheter, the catheter is just to the centre of a circle of test tube, detect needle fixed mounting on passive carousel, detect needle is located one side of catheter, detect the end of needle stretches into in the test tube, test tube intracavity is arranged in to the test tube, test tube intracavity is installed on the revolving stage, revolving stage fixed mounting is in the base.
Further, it is preferable that the number of the detecting needles is at least 1.
Further, it is preferable that the battery is mounted in the base.
Further, preferably, the operation panel is provided with a display screen.
Further, the preferred structure is that a bar code scanner is installed on the base.
A method for automatically acquiring a thromboelastography comprises the following specific steps:
s1, a rotating table is arranged in a base, a test tube cavity is fixed on the rotating table, and a test tube is placed in the test tube cavity;
s2, a passive turntable is arranged in the lifting detection table, a liquid guide pipe is arranged at the center of the passive turntable, and the liquid guide pipe is controlled to automatically add blood to be detected and various coagulation starting reagents to the test tube by controlling the lifting detection table;
s3, after the blood to be tested and various coagulation starting reagents are added, lifting the detection table to descend, and enabling the tail end of the detection needle arranged on the passive turntable to extend into the blood to be tested in the test tube; the detection needle is kept at a non-center position of the test tube so as to realize that the blood reaction liquid to be detected in the test tube rotates to drive the detection needle to rotate;
s4, starting a rotary table, and driving the test tube to synchronously rotate by the rotary table;
s5, when blood starts to coagulate, resistance is generated between the test tube and the detection needle due to the net combination of the fibrin adhesion and the blood platelets, the rotation of the test tube drives the detection needle to move simultaneously, the resistance is also continuously increased along with the increase of fibrin, and the movement of the test tube driving the detection needle is also changed along with the increase of fibrin;
s6, when blood is dissolved in the fibrinolysis process, the rotation speeds of the detection needle and the passive turntable are changed along with the dissolution;
s7, recording the relative rotation speed of the passive turntable, so that the elastic characteristic of thrombus is obtained, and measuring the coagulation process of blood in an electric signal mode, so that the monitoring and analysis of the thrombus elasticity of the blood to be measured are realized.
Further, the preferred method is that the length of the detection needle extending downwards from the passive turntable is longer than the length of the catheter extending downwards from the passive turntable;
when the rotary table starts to work, the tail end of the liquid guiding tube is kept in a state of being separated from the test tube, so that the accuracy of the detection result is improved.
In the preferred method in S3, the middle lower portion of the test needle extends into the test solution completely, so as to increase the contact area between the test needle and the blood to be tested.
Further, a fixed table is arranged outside the test tube cavity, and the fixed table is heated, so that the test tube inside the fixed table is heated in an air rotating mode, and the test tube is kept in a 37-DEG constant temperature state.
Further, in a preferred method, the material of the fixing table is titanium alloy.
Compared with the prior art, the method and the device for automatically acquiring the thromboelastography have the following beneficial effects:
1. the relative rotation speed is utilized to realize the measurement of the thromboelastography, so that the stability is higher, and the conclusion is more reasonable and accurate than the data obtained by sector swing;
2. the integration degree of the equipment is high, the structure is compact, and the device is practical and efficient;
3. the method can automatically add blood to be detected and various reagents related to coagulation (starting coagulation reagent) to avoid cross contamination, greatly improve the degree of automation, reduce the workload of medical staff and lead the detection result to be more accurate;
4. the utility model realizes one-time blood collection and one machine, can obtain the blood coagulation formation time under the action of various blood coagulation factors, the overall appearance of the blood coagulation process and the ablation time of blood clots at one time, and is used for various occasions (before operation/blood transfusion) needing to measure blood coagulation; the inhibition effect of aspirin and thienopyridine drugs on platelets can be evaluated, and whether excessive use of various heparin and heparin resistance exist or not can be evaluated in an auxiliary manner; the pain of the patient in blood sampling for many times can be relieved, and the detection efficiency is improved;
5. the display screen is arranged, so that the running state is faithfully displayed, convenience is provided for doctors to work, and the working efficiency is improved;
6. the maintenance of a constant temperature state of 37 ℃ can be realized, so that the detection result is more accurate;
7. before the start-up coagulation reagent is added, the blood to be measured can drive the passive turntable to generate rotating speed due to the self viscosity, so that the measurement of the viscosity coefficient and the blood rheological property of the blood can be realized.
Drawings
FIG. 1 is a schematic diagram of a device for automatically acquiring a thromboelastography;
FIG. 2 is a cross-sectional view of an apparatus for automatically acquiring a thromboelastography;
wherein: 1. an operation panel; 2. lifting the detection table; 3. a passive turntable; 4. a catheter; 5. a detection needle; 6. a test tube chamber; 7. a rotary table; 8. a storage battery; 9. a base; 10. a guide rail; 11. a housing; 12. a display screen; 13. a bar code scanner.
Detailed Description
In the description of the present utility model, it should be noted that the indicated orientations or positional relationships of the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", "top", "end", etc. are based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "coupled" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases to those of ordinary skill in the art.
Example 1:
the utility model provides an automatic acquire device of thrombus elastography, including casing 11 and base 9, the top of casing 11 is equipped with operating panel 1, operating panel 1's below is equipped with lift detection platform 2, lift detection platform 2 passes through guide rail 10 and installs on casing 11 with sliding relatively, lift detection platform 2 internally mounted has passive carousel 3, the centre of a circle downwardly extending of passive carousel 3 is run through to catheter 4, catheter 4 is just right the centre of a circle of test tube, a detection needle 5 fixed mounting is on passive carousel 3, detection needle 5 is located one side of catheter 4, the terminal of detection needle 5 stretches into the test tube, the centre of a circle of detection needle 5 and test tube is not in a straight line, test tube is arranged in test tube chamber 6, test tube chamber 6 installs on revolving stage 7, revolving stage 7 fixed mounting is in base 9.
Further, a storage battery 8 is installed in the base.
Further, the operation panel 1 is provided with a display screen 12, and the operation status of the device can be intuitively displayed on the display screen 12.
Further, a bar code scanner 13 is installed on the base 9.
Further, a fixed table is arranged outside the test tube cavity 6, the fixed table is used for heating, and the air is used for rotating and heating the test tube inside, so that the temperature of the test tube inside is kept at a constant temperature of 37 ℃. The fixed table is made of titanium alloy, so that heat can be transferred better.
Example 2:
the utility model provides an automatic acquire device of thrombus elastography, including casing 11 and base 9, the top of casing 11 is equipped with operating panel 1, operating panel 1's below is equipped with lift detection platform 2, lift detection platform 2 passes through guide rail 10 and installs on casing 11 with sliding relatively, lift detection platform 2 internally mounted has passive carousel 3, the centre of a circle downwardly extending of passive carousel 3 is run through to catheter 4, catheter 4 is just right the centre of a circle of test tube, 2 detection needle 5 fixed mounting is on passive carousel 3, 2 detection needle 5 sets up for catheter 4 symmetry, the terminal of detection needle 5 stretches into the test tube, the test tube is arranged in test tube chamber 6, test tube chamber 6 installs on revolving stage 7, revolving stage 7 fixed mounting is in base 9. The length of the catheter 4 is shorter than the length of the detection needle 5 (i.e. the length of the detection needle 5 extending downwards from the passive turntable 3 is longer than the length of the catheter 4 extending downwards from the passive turntable 3), so that when the detection is performed, the detection needle 5 extends into the blood to be detected in the test tube, and the catheter 4 is kept above the blood to be detected, so that the measurement error is reduced, and the detection result is more accurate.
Further, a storage battery 8 and a bar code scanner 13 are arranged in the base.
Further, the operation panel 1 is provided with a display screen 12, and the operation status of the device can be intuitively displayed on the display screen 12.
In the device for automatically acquiring the thromboelastography, the specific detection structures can be arranged in a plurality of groups in the same device so as to realize simultaneous detection of a plurality of groups of blood to be detected.
The method can realize the blood coagulation forming time under the action of various blood coagulation factors of a plurality of blood samples to be measured at one time, the overall appearance of the blood coagulation process and the ablation time of blood clots, and is used for various occasions (preoperative/pretransfusion) needing to measure blood coagulation; the inhibition effect of aspirin and thienopyridine drugs on platelets can be evaluated, and whether excessive use of various heparin and heparin resistance exist or not can be evaluated in an auxiliary manner; the detection efficiency is greatly improved.
The specific operation method is as follows:
s1, firstly, scanning a bar code through a bar code scanner 13, confirming patient information of blood to be tested, and then placing a test tube in a test tube cavity 6; the fixed table at the outer side of the test tube cavity 6 is heated to keep the temperature of the test tube at 37 ℃;
s2, a passive turntable 3 is arranged in the lifting detection table 2, a liquid guide tube 4 is arranged at the center of the passive turntable 3, and the liquid guide tube 4 is controlled to automatically add blood to be detected, various blood coagulation related reagents (start coagulation reagents) to a test tube by controlling the lifting detection table 2;
s3, after the blood to be tested and various coagulation starting reagents are added, the lifting detection table 2 is lowered, so that the liquid guide tube 4 leaves the test tube, the liquid guide tube 4 is kept above the test tube, and meanwhile, the detection needle 5 is kept extending into the blood to be tested in the test tube; the middle lower part of the detection needle 5 fully stretches into the liquid to be detected, so that the contact area between the detection needle 5 and the blood to be detected is increased, the detection is more sensitive, and the detection result is more accurate;
s4, starting a rotary table 7, and driving the test tube to synchronously rotate by the rotary table 7;
s5, when blood starts to coagulate, resistance is generated between the test tube and the detection needle 5 due to the net combination of the fibrin adhesion and the platelets, the rotation of the test tube drives the detection needle 5 to move simultaneously, the resistance is also increased continuously along with the increase of fibrin, and the movement of the test tube driving the detection needle 5 is also changed along with the increase of fibrin;
s6, when blood is dissolved due to the fibrinolysis process, the rotation speeds of the detection needle 5 and the passive turntable 3 are changed along with the dissolution;
s7, recording the relative rotation speed of the passive turntable 3, so as to obtain the elasticity characteristic of thrombus, and measuring the coagulation process of blood in an electric signal mode, so that the monitoring and analysis of the thrombus elasticity of the blood to be measured are realized.
The detection items and the clinical meanings of the detection items which can be obtained by the method for automatically obtaining the thromboelastography are shown in the following table:
wherein the main reference index is as follows:
r-value clotting factor duration of action; k value clot formation initiation time; angle value clot formation rate; MA value maximum clot strength; CI coagulation complex index; EPL predicts the clot amplitude dissolution percentage within 30 minutes; LY30 fibrinolysis measurement.
Meaning of the detection item
In the utility model, the relative rotation speed is utilized to realize the measurement of the thromboelastography, while the rotation speed measurement technology is very mature, and various prior technologies can be adopted, such as a Hall sensor mode, a magneto-electric sensor mode, a photoelectric sensor mode or an encoder mode.
Various coagulation-related reagents (starting coagulation reagents) added in the utility model, including heparinase, kaolin, diatomite, attapulgite clay, rabbit brain powder (tissue thromboplastin), partial thromboplastin cephalin suspension, thrombin, caCl 2 Batroxobin, adenosine diphosphate, arachidonic Acid (AA), adenosine Diphosphate (ADP) and the like, and the mixture is added according to actual needs.
The blood to be measured is heparin sodium anticoagulation or sodium citrate anticoagulation and the like according to actual needs, wherein the sodium citrate anticoagulation is venous blood collection, and the blood is injected into a qualified sodium citrate anticoagulation tube, namely 109mmol/L sodium citrate is uniformly mixed with whole blood according to the ratio of 1:9; heparin sodium anticoagulation, venous blood sampling, injection into heparin anticoagulation tube, and mixing uniformly. The heparin sodium concentration in the tube is required to be not less than 14.5U/ml.
The method can be applied to colorimetric equipment, the corresponding adopted test tube is a colorimetric test tube, the thromboelastography can be obtained, the fibrinogen content FIB can be detected, and the equipment has high integration degree, compact structure, practicability and high efficiency.
The present utility model can be easily implemented by those skilled in the art through the above specific embodiments. It should be understood that the utility model is not limited to the particular embodiments described above. Based on the disclosed embodiments, a person skilled in the art may combine different technical features at will, so as to implement different technical solutions.
Claims (10)
1. The utility model provides an automatic acquire device of thrombus elastography, which comprises a housin and a pedestal, a serial communication port, the top of casing is equipped with operating panel, operating panel's below is equipped with the lift and detects the platform, lift detects the platform and installs on the casing through the guide rail relative slip, lift detects platform internally mounted has passive carousel, the centre of a circle downwardly extending of passive carousel is run through to the catheter, the catheter is just to the centre of a circle of test tube, detect needle fixed mounting on passive carousel, detect needle is located one side of catheter, detect the end of needle and stretch into in the test tube, test tube is arranged in the test tube intracavity, test tube chamber installs on the revolving stage, revolving stage fixed mounting is in the base.
2. The apparatus for automatically acquiring a thromboelastography according to claim 1, wherein said number of detecting needles is at least 1.
3. The apparatus for automatically acquiring a thromboelastography according to claim 1, wherein a battery is installed in the base.
4. The device for automatically acquiring a thromboelastography according to claim 1, wherein said operation panel is provided with a display.
5. An apparatus for automatically acquiring a thromboelastography according to any one of claims 1-4 wherein said base is provided with a bar code scanner.
6. A method for automatically acquiring a thromboelastography, which is characterized by comprising the following steps:
s1, a rotating table is arranged in a base, a test tube cavity is fixed on the rotating table, and a test tube is placed in the test tube cavity;
s2, a passive turntable is arranged in the lifting detection table, a liquid guide pipe is arranged at the center of the passive turntable, and the liquid guide pipe is controlled to automatically add blood to be detected and various coagulation starting reagents to the test tube by controlling the lifting detection table;
s3, after the blood to be tested and various coagulation starting reagents are added, lifting the detection table to descend, and enabling the tail end of the detection needle arranged on the passive turntable to extend into the blood to be tested in the test tube; the detection needle is kept at a non-center position of the test tube so as to realize that the blood reaction liquid to be detected in the test tube rotates to drive the detection needle to rotate;
s4, starting a rotary table, and driving the test tube to synchronously rotate by the rotary table;
s5, when blood starts to coagulate, resistance is generated between the test tube and the detection needle due to the net combination of the fibrin adhesion and the blood platelets, the rotation of the test tube drives the detection needle to move simultaneously, the resistance is also continuously increased along with the increase of fibrin, and the movement of the test tube driving the detection needle is also changed along with the increase of fibrin;
s6, when blood is dissolved in the fibrinolysis process, the rotation speeds of the detection needle and the passive turntable are changed along with the dissolution;
s7, recording the relative rotation speed of the passive turntable, so that the elastic characteristic of thrombus is obtained, and measuring the coagulation process of blood in an electric signal mode, so that the monitoring and analysis of the thrombus elasticity of the blood to be measured are realized.
7. The method of automatically acquiring a thromboelastography according to claim 6, wherein said sensing needle extends downward from the passive turntable for a length greater than a length of the catheter extending downward from the passive turntable;
when the rotary table starts to work, the tail end of the liquid guiding tube is kept in a state of being separated from the test tube, so that the accuracy of the detection result is improved.
8. The method according to claim 6, wherein in S3, the middle lower portion of the test needle extends completely into the fluid to be tested to increase the contact area between the test needle and the blood to be tested.
9. The method for automatically acquiring a thromboelastography according to claim 6, wherein a fixed stage is provided outside a tube chamber, and the tube inside the fixed stage is heated by heating the fixed stage to thereby rotate the air to maintain the tube in a constant temperature state of 37 ℃.
10. The method of claim 9, wherein the fixing base is made of titanium alloy.
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| CN201611252119.3A CN106771108B (en) | 2016-12-29 | 2016-12-29 | Method and device for automatically acquiring thromboelastography |
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| CN201611252119.3A CN106771108B (en) | 2016-12-29 | 2016-12-29 | Method and device for automatically acquiring thromboelastography |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108254578A (en) * | 2018-04-12 | 2018-07-06 | 佛山市恩正生物医药科技有限公司 | A kind of thrombus elastometer |
| CN109085367B (en) * | 2018-07-31 | 2023-09-26 | 美德太平洋（天津）生物科技股份有限公司 | Portable coagulometer with protecting device |
| CN111579398B (en) * | 2020-05-28 | 2023-04-07 | 常熟常江生物技术有限公司 | External thrombus physical property detection device |
| CN113219188A (en) * | 2021-04-25 | 2021-08-06 | 深圳沃德生命科技有限公司 | Integrated modular structure and equipment for thrombus elasticity and blood coagulation analysis |
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