CN114128786A - Preparation for promoting digestion of animals and preparation method thereof - Google Patents

Abstract

The invention discloses a composition for promoting digestion of animals, which comprises the following components in parts by weight: 6-60 parts of choerospondias axillaris, 3-20 parts of hawthorn extract, 6-20 parts of barley malt extract, 7-20 parts of radish seed extract, 6-20 parts of white hyacinth bean extract and 6-20 parts of coix seed extract. The composition is composed of natural substances, is safe without side effects, has excellent thickening and stability, and has unique flavor, thereby remarkably improving palatability.

Description

Preparation for promoting digestion of animals and preparation method thereof

Technical Field

The invention relates to the technical field of feed additives, in particular to a preparation for promoting digestion of animals and a preparation method and application thereof.

Background

At present, the most widely used method for treating animal clinical diseases is that the problems of antibiotics, bacterial drug resistance and the like are more serious, and the situation that the clinical treatment effect is not obvious and even no drug is available appears. The long-term treatment with large dose of antibiotics not only causes serious burden to the liver and kidney of animals, but also induces a series of problems of aplastic anemia, flora disorder and the like. Antibiotics cause drug resistance problem, so that the generation of super bacteria threatens not only animal medical industry but also human public health safety.

The hormone medicine is also a common medicine for animal clinic, and has the characteristics of quick response, low dosage and the like, but the problems of endocrine disorder, immunosuppression, metabolic disorder and the like of animals caused by the hormone medicine become more serious day by day, and even serious iatrogenic diseases are caused, such as skin fragility syndrome caused by long-term use of glucocorticoid medicine.

With the continuous occurrence of reports of toxic and side effects of chemical drugs and the like, when animal owners treat diseases of animals, the animal owners are not limited to the treatment effect of the drugs, and the animal owners also have toxic and side effects caused by the loss of the drugs to organisms, particularly when the animals are sick and need long-term treatment, and the chemical drugs only can play a treatment role temporarily and cannot achieve the effects of long-term regulation and health care. In view of the above situations, the advantages of traditional Chinese medicine in animal clinical treatment are slowly highlighted, and the unique theoretical system and the drug treatment characteristics of traditional Chinese medicine are in disagreement with the requirements of animal medical industry at present. The traditional Chinese medicine is natural organic matter, has the characteristics of naturalness, no toxic or side effect, no drug resistance and the like, and can effectively reduce the drug residue of animal products.

In view of the above problems, the present invention aims to disclose an animal digestion promoting preparation and a preparation process thereof, wherein the preparation has more excellent stability and thickening property and obviously improved palatability compared with the traditional animal digestion promoting preparation. In the traditional animal digestion-promoting preparation, for example, sodium carboxymethylcellulose (NaCMC) is used as a stabilizer and a thickening agent, the NaCMC is greatly influenced by temperature and pH value, the preparation cannot be stabilized when the addition amount of the NaCMC is small, and researches report that the absorption of trace elements is influenced by the NaCMC.

Disclosure of Invention

The invention mainly aims to provide a composition for preventing and/or treating dyspepsia and inappetence, which has definite curative effect, less adverse reaction and natural safety, and solves the problems of obvious toxic and side effects, easy generation of drug resistance, and easy generation of endocrine disorder, immune suppression and metabolic disorder of animals in the prior art.

In order to achieve the above object, according to one aspect of the present invention, there is provided a composition for promoting digestion of animals, comprising, in parts by weight: 6-60 parts of choerospondias axillaris, 3-20 parts of hawthorn extract, 6-20 parts of barley malt extract, 7-20 parts of radish seed extract, 6-20 parts of white hyacinth bean extract and 6-20 parts of coix seed extract.

Further, the composition comprises the following components in parts by weight: about 60 parts of choerospondias axillaris, about 20 parts of hawthorn extract, about 20 parts of barley malt extract, about 20 parts of radish seed extract, about 20 parts of white hyacinth bean extract and about 20 parts of coix seed extract.

Further, the composition further comprises one or more of the following: flavoring powder, water soluble cellulose, milk powder, yolk powder, amino acids and protein peptide.

Further, the flavor powder is selected from one or more of the following: chicken liver powder, chicken meat powder, beef powder and polypeptide fish powder.

Further, the water-soluble cellulose includes polydextrose and/or oligosaccharide.

Further, the amino acid is lysine and/or taurine.

Further, the oligosaccharide is selected from one or more of the following: fructo-oligosaccharide, isomalto-oligosaccharide, lacto-oligosaccharide, mannose-oligosaccharide, soybean oligosaccharide, chitosan oligosaccharide, xylo-oligosaccharide and galacto-oligosaccharide.

Further, the composition further comprises the following components in parts by weight: 250 parts of flavor correcting powder 175, 34-80 parts of water-soluble cellulose, 58-100 parts of milk powder, 25-80 parts of egg yolk powder, 40-70 parts of amino acid and 20-40 parts of protein peptide.

Further, the composition further comprises the following components in parts by weight: 200 parts of flavor correcting powder 175-one, 34-62 parts of water-soluble cellulose, 58-78 parts of milk powder, 25-55 parts of egg yolk powder, 40-50 parts of amino acid and 20-30 parts of protein peptide.

Further, the composition further comprises the following components in parts by weight: 200 parts of flavor correcting powder, 62 parts of water-soluble cellulose, 78 parts of milk powder, 55 parts of yolk powder, 50 parts of amino acid and 30 parts of protein peptide.

Further, the composition further comprises a nutritional supplement.

Further, the nutritional supplement is a vitamin and/or a trace element.

Further, the composition does not include an antibiotic.

Further, the composition does not include a hormone.

Further, the animal is a mammal.

Further, the animal is a human.

Further, the animal is a pet.

Further, the pet is a cat, dog, mouse or rabbit.

According to another aspect of the present invention, there is provided a formulation comprising the above composition, the formulation further comprising an adjuvant.

Further, the preparation is oral liquid, lotion, ointment or plaster.

Further, the adjuvants include antioxidant, antiseptic, sweetener and/or pH regulator.

Further, the antioxidant is selected from one or more of the following: tea polyphenols, lutein, carotene and curcumin.

Further, the preservative is sodium benzoate.

Further, the sweetener is sucrose.

Further, the pH regulator is citric acid.

Further, the adjuvant does not include a thickener.

Further, the thickener is selected from one or more of the following: sodium hydroxymethyl cellulose, gelatin and agar.

According to another aspect of the present invention, there is provided a use of the above composition or the above preparation for the preparation of a medicine, food and health care product for preventing and/or treating dyspepsia, anorexia.

According to another aspect of the present invention, there is provided a method of preparing the above formulation, the method comprising the steps of:

1) weighing appropriate amount of fructus crataegi extract, fructus Hordei Germinatus extract, Raphani semen extract, semen lablab album extract, Coicis semen extract, water soluble cellulose, flavoring powder, milk powder, yolk powder, amino acids, and protein peptide, and mixing to obtain a first mixture;

2) adding a proper amount of water to the first mixture to obtain a second mixture;

3) weighing a proper amount of choerospondias axillaris and an antioxidant according to the proportion, adding the choerospondias axillaris and the antioxidant into the second mixture, and homogenizing and stirring to obtain a third mixture;

4) adding appropriate amount of antiseptic, sweetener, pH regulator and water into the third mixture, and regulating pH to 4.6-5.0 and viscosity to 400-500mPa.s to obtain a fourth mixture; and

5) and sterilizing the fourth mixture for 10-60 min under the conditions of 0.1-0.36 MPa, high temperature and high pressure of 100-140 ℃, and cooling to room temperature to obtain the preparation.

Further, the speed of the homogeneous stirring is 23 to 27 r/min.

Further, the temperature of the homogeneous stirring is controlled in the range of 40 ℃ to 50 ℃.

Further, the fourth mixture is sterilized at about 103.4kPa at about 121.3 ℃ for about 20 min.

The invention has the beneficial effects that:

the composition disclosed by the invention can enhance the digestion function of animals, and the natural pectin in the choerospondias axillaries is used as a coagulation emulsifier, so that the product is excellent in thickening property and stability, unique in flavor, strong in fragrance, natural, safe and free of toxic and side effects.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without departing from the scope of the present invention as claimed.

Fig. 1 is a flow chart of a preparation process of the animal digestion-promoting suspension oral liquid.

Fig. 2 is a bar graph of the oral suspension liquid sample prepared in preparation example 4 of the present invention with respect to the intake rate of the oral liquid for promoting digestion of animals.

Fig. 3 is a schematic view showing the state of a suspension oral liquid sample (choerospondias axillaris suspension oral preparation) prepared by preparative example 4 and a control sample (gaffeta raw formula suspension preparation) according to the present invention (after the two preparation samples were left standing for three months in a sealed state, the two preparation samples were respectively poured on white paper).

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention described herein may include one or more numerical ranges (e.g., parts by weight, time, temperature, pressure, etc.). A range of values is understood to include all values within the range, including the values that define the range, as well as values adjacent to the range that produce the same or substantially the same result as the values immediately adjacent to the value defining the boundary of the range.

To the extent that the terms "includes," including, "" comprises, "and" having "or variants thereof are used in either the detailed description and/or the claims, these terms are intended to be inclusive in a manner similar to the term" comprising.

As used herein, "about" refers to a value within a range of + -10% of one particular value. For example, "about 20" includes ± 10% of 20, or from 18 to 22, including 18 and 22.

As described in the background section, the existing common drugs for preventing and/or treating animal dyspepsia and inappetence have obvious toxic and side effects, are easy to generate drug resistance, and easily cause the problems of animal endocrine disorder, immunosuppression and metabolic disorder. In order to solve the problems, the invention provides a composition for promoting digestion of animals, which comprises the following components in parts by weight: 6-60 parts of choerospondias axillaris, 3-20 parts of hawthorn extract, 6-20 parts of barley malt extract, 7-20 parts of radish seed extract, 6-20 parts of white hyacinth bean extract and 6-20 parts of coix seed extract.

The composition of the invention uses natural raw materials, can be eaten for a long time, has moderate acidity and low cost. When the parts by weight of choerospondias axillaris exceeds 60 parts by weight, acidity increases (i.e., PH decreases) and consistency increases, palatability decreases and cost increases.

The choerospondias axillaris in the raw materials of the composition can help digestion, promote qi and blood circulation, nourish heart, tranquilize mind and expel parasites; white hyacinth bean and coix seed, invigorating spleen, promoting diuresis and stopping diarrhea; hawthorn and barley malt, which can remove food retention and promote digestion; lai Fu Zi can expel qi and remove food stagnation.

In order to better understand the present invention, the following further explains the effects of some Chinese medicinal materials in the composition of the present invention.

Choerospondias axillaris (Choerospondias axilaris (Roxb.) Burtt et Hill.) has effects of activating qi-flowing, promoting blood circulation, nourishing heart, and tranquilizing mind. Promoting digestion, removing toxic substances, relieving hangover, and killing parasites, and is a traditional Chinese medicine for Mongolian medicine. The fresh pulp of the choerospondias axillaris contains abundant pectin and nutrient components, the amino acid types of the fresh pulp are as many as 18, and the fresh pulp of the choerospondias axillaris also has extremely abundant protein content and organic acid content; the choerospondias axillaris flesh and the jujube peel also contain rich nutrient mineral elements such as Ca, Fe, Zn, Cu, P and the like and some bioactive substances and the like; the total flavone in the choerospondias axillaris fruits is considered as an effective component of the choerospondias axillaris fruits, has various physiological activities, and has the effects of resisting arrhythmia and protecting ischemic myocardium through research verification; in addition, the choerospondias axillaris fruit also has the effects of scavenging free radicals and resisting oxidation.

Hawthorn (Crataegus pinnatifida) is a traditional Chinese medicine, belongs to Crataegus genus of Rosaceae family, is recorded in Ben Cao Jing Ji Zhu, and has the effects of strengthening spleen, stimulating appetite, promoting digestion, removing food stagnation, promoting blood circulation, eliminating phlegm, expelling tapeworm, treating hernia, promoting growth and the like. Modern researches find that the hawthorn is applied to a cardiovascular system and a cerebrovascular system, can reduce blood pressure, reduce blood fat, resist atherosclerosis, arrhythmia, myocardial ischemia and inhibit brain cell apoptosis, is applied to a digestive system, can bidirectionally regulate gastrointestinal tract peristalsis, promote secretion of digestive enzyme, protect liver, is applied to an endocrine system, can reduce blood sugar and prevent and treat diabetic complications, and simultaneously has antibacterial and antitumor effects.

Malt, a mature fruit of the annual herbaceous plant barley of the family Gramineae (Hordeum vulgare L.) is obtained by sprouting and drying, and is a common food-digesting medicine in clinical practice of traditional Chinese medicine. It is sweet in taste and neutral in nature, and enters spleen and stomach meridians. Has effects in promoting qi circulation, resolving food stagnation, invigorating spleen, stimulating appetite, and relieving lactation. Is used for treating indigestion, abdominal pain and distention, spleen deficiency and poor appetite, milk stasis and breast swelling and pain, and is a common indigestion-relieving medicine in clinical traditional Chinese medicine.

White hyacinth bean is dry white ripe seed of Leguminosae plant hyacinth bean (Dolichos lablab L.). The book Ben Cao gang mu states that the hyacinth beans regulate the liver and stomach, clear summer-heat and dispel dampness, stop diarrhea, the book Lu Dou she Zhong Xian Qi from Ming Yi Bie Lu records that the hyacinth beans can ascend the clear and descend the turbid, so it has the efficacy of regulating the liver and stomach. It can be used for treating spleen deficiency, emesis, anorexia, chronic diarrhea, leucorrhea with red and white discharge, alcoholic intoxication, emesis, etc. The white hyacinth bean has high nutritive value, the carbohydrate content is as high as about 57%, and in addition, the white hyacinth bean also contains protein, fat, trace calcium, phosphorus, iron, various vitamins and the like.

Coix lacryma-jobi L.var.mayuen (Roman.) Stapf) is dry and mature seed kernel of Coix lacryma-jobi of Gramineae, has cold nature and sweet taste, and has effects of inducing diuresis, relieving swelling, invigorating spleen, eliminating dampness, clearing heat, and expelling pus. Modern pharmacological studies show that the coix seeds have the effects of resisting tumors, reducing blood sugar, resisting inflammation, relieving pain, improving immunity, regulating blood fat metabolism, inhibiting osteoporosis and the like, and are widely used medical and edible health-care food.

In order to obtain a composition that is more stable and thickening and more palatable (i.e. having suitable acidity), in a preferred embodiment, the composition comprises, in parts by weight: about 60 parts of choerospondias axillaris, about 20 parts of hawthorn extract, about 20 parts of barley malt extract, about 20 parts of radish seed extract, about 20 parts of white hyacinth bean extract and about 20 parts of coix seed extract.

In a preferred embodiment, the composition further comprises one or more of the following: flavoring powder, water soluble cellulose, milk powder, yolk powder, amino acids and protein peptide.

In the invention, the water-soluble cellulose and the plant traditional Chinese medicinal material components are used together to help digestion, improve the flora balance of gastrointestinal tracts and solve the indigestion of animals caused by various problems.

In a preferred embodiment, the flavor powder is selected from one or more of the following: chicken liver powder, chicken meat powder, beef powder and polypeptide fish powder.

In a preferred embodiment, the water-soluble cellulose comprises polydextrose and/or an oligosaccharide.

In the invention, the polydextrose and the oligosaccharide can promote intestinal microecological balance, improve digestive function and maintain gastrointestinal health.

In a preferred embodiment, the amino acid is lysine and/or taurine.

In a preferred embodiment, the oligosaccharide is selected from one or more of the following: fructo-oligosaccharide, isomalto-oligosaccharide, lacto-oligosaccharide, mannose-oligosaccharide, soybean oligosaccharide, chitosan oligosaccharide, xylo-oligosaccharide and galacto-oligosaccharide.

In a preferred embodiment, the composition further comprises, in parts by weight: 250 parts of flavor correcting powder 175, 34-80 parts of water-soluble cellulose, 58-100 parts of milk powder, 25-80 parts of egg yolk powder, 40-70 parts of amino acid and 20-40 parts of protein peptide.

In a preferred embodiment, the composition further comprises, in parts by weight: 200 parts of flavor correcting powder 175-one, 34-62 parts of water-soluble cellulose, 58-78 parts of milk powder, 25-55 parts of egg yolk powder, 40-50 parts of amino acid and 20-30 parts of protein peptide.

To further balance the flora of the gastrointestinal tract, enhance digestive function of the animal, and enhance palatability, in a preferred embodiment, the composition further comprises, by weight: 200 parts of flavor correcting powder, 62 parts of water-soluble cellulose, 78 parts of milk powder, 55 parts of yolk powder, 50 parts of amino acid and 30 parts of protein peptide.

In a preferred embodiment, the composition further comprises a nutritional additive.

In a preferred embodiment, the nutritional supplement is a vitamin and/or a trace element.

In a preferred embodiment, the composition does not include an antibiotic.

In a preferred embodiment, the composition does not include a hormone.

In a preferred embodiment, the animal is a mammal.

In a preferred embodiment, the animal is a human.

In a preferred embodiment, the animal is a pet.

In a preferred embodiment, the pet is a cat, dog, mouse or rabbit.

According to another aspect of the present invention, there is provided a formulation comprising the above composition, the formulation further comprising an adjuvant.

In a preferred embodiment, the formulation is an oral liquid, a lotion, an ointment or a plaster.

In a preferred embodiment, the adjuvants include antioxidants, preservatives, sweeteners and/or PH regulators.

In a preferred embodiment, the antioxidant is selected from one or more of the following: tea polyphenols, lutein, carotene and curcumin.

In a preferred embodiment, the preservative is sodium benzoate.

In a preferred embodiment, the sweetener is sucrose.

In a preferred embodiment, the PH adjusting agent is citric acid.

In a preferred embodiment, the adjuvant does not include a thickener.

In a preferred embodiment, the thickener is selected from one or more of the following: sodium hydroxymethyl cellulose, gelatin and agar.

The thickener may also be other thickeners known in the art, such as alginic acid, carrageenan, pectin, locust bean gum, cassia gum, guar gum, xanthan gum, gum arabic, maltodextrin, soluble soy polysaccharide, konjac gum, casein, gellan gum, sodium starch phosphate, and sodium starch glycolate.

According to another aspect of the present invention, there is provided a use of the above composition or the above preparation for the preparation of a medicine, food and health care product for preventing and/or treating dyspepsia, anorexia.

According to another aspect of the present invention there is provided a method of preventing and/or treating a disease or condition selected from dyspepsia and anorexia in an animal in need thereof, wherein the method comprises orally administering to the animal a therapeutically effective amount of a composition or formulation as described above.

Wherein "therapeutically effective amount" comprises an amount sufficient to ameliorate or prevent a symptom or condition of a medical condition. An effective amount also means an amount sufficient to allow or facilitate diagnosis. The effective amount will depend on the health and physical condition of the individual to be treated, the classification of the individual to be treated, the formulation of the composition, the assessment of the medical condition, and other relevant factors. It is expected that this amount will fall within a relatively wide range that can be determined by routine experimentation. An effective amount may be the maximum dose or dosage regimen that avoids significant side effects or toxic effects.

Furthermore, the above-described compositions or the above-described formulations of the present invention may be combined with one or more other compounds or one or more other therapeutic agents known in the art, in any combination thereof, for the treatment of the diseases and conditions provided by the present invention.

According to another aspect of the present invention, there is provided a method of preparing the above formulation, the method comprising the steps of:

1) weighing appropriate amount of fructus crataegi extract, fructus Hordei Germinatus extract, Raphani semen extract, semen lablab album extract, Coicis semen extract, water soluble cellulose, flavoring powder, milk powder, yolk powder, amino acids, and protein peptide, and mixing to obtain a first mixture;

2) adding a proper amount of water to the first mixture to obtain a second mixture;

3) weighing a proper amount of choerospondias axillaris and an antioxidant according to the proportion, adding the choerospondias axillaris and the antioxidant into the second mixture, and homogenizing and stirring to obtain a third mixture;

4) adding appropriate amount of antiseptic, sweetener, pH regulator and water into the third mixture, and regulating pH to 4.6-5.0 and viscosity to 400-500mPa.s to obtain a fourth mixture; and

5) and sterilizing the fourth mixture for 10-60 min under the conditions of 0.1-0.36 MPa, high temperature and high pressure of 100-140 ℃, and cooling to room temperature to obtain the preparation.

In a preferred embodiment, the speed of the homogeneous stirring is from 23 to 27 r/min.

In a preferred embodiment, the temperature of the homogeneous stirring is controlled in the range of 40 ℃ to 50 ℃.

In the present invention, heat treatment at a range of temperatures induces chemical modification of formulation components, primarily sugars and amino acids, resulting in a range of flavor compounds, thereby significantly increasing the palatability of the formulation.

In a preferred embodiment, the fourth mixture is sterilized at about 103.4kPa at an elevated temperature and pressure of about 121.3 ℃ for about 20 minutes.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail with reference to examples.

The present invention is described in further detail below with reference to specific examples, which are not to be construed as limiting the scope of the invention as claimed herein.

Preparative experiments

Experimental Material

The southern wild jujube is Jiangxi, and is identified as southern wild jujube (Choerospondias axillis (Roxb.) Burtt et Hill.) by the Zhu Jing teacher of Chinese institute of traditional Chinese medicine of Chinese academy of sciences.

Parched semen lablab album extract (batch No. 202190701); hawthorn extract (batch No. 2021082501); barley malt extract (batch No. 2021090501); coix seed extract (batch No. 2021032501); raphani semen extract (batch No. 2021041801) was obtained from Siam Oersai Biotech limited.

Polydextrose was sourced from bowling biological shares, ltd, under lot number 21072611.

Fructooligosaccharides were obtained from bowling Bio-Res Ltd under batch number 21011312.

Galactooligosaccharides were obtained from bowling Bio Inc. under batch number 21071861.

The milk powder is from Nanjing Qin Green food Co., Ltd, and has a batch number of 23079174.

The egg yolk powder is prepared from Shandong Xinfulong bioengineering GmbH, and has a batch number of 20210608.

The amino acid is obtained from Xianlv such as spring Biotech, Inc., under the batch number 20210116.

The protein peptide is from Jinan Jieyang Biotech limited, under the batch number of 20210420.

Carotene was derived from the Western Anoece Biotechnology under batch number 2021040602.

The chicken liver powder is from Jiangsu Yimai biological science and technology limited company, and the batch number is MXY 20210805.

The chicken powder is from Jiangsu Ganfeng biotechnology limited company with the batch number of 2021052711.

The polypeptide fish meal is from Shanghai Yihui biotechnology, Inc., and has a batch number of 44351.

Tea polyphenols are from the bioscience of western aucklandia under the lot number 2021042201.

Lutein is from the biotech limited of saint meikang beijing under the batch number 20200626.

Curcumin is from Siman Rui Ying Biotechnology Ltd, lot No. RY 20210520.

L-lysine hydrochloride was obtained from Hebei Huayang Biotech, Inc. under the batch number 21010126.

Taurine is from the pharmaceutical industry GmbH of Yongjiang, Ngjiang, under the batch number FX 21013056.

The citric acid is from Weifang Yinxuan industry Co Ltd, and the batch number is 20210310.

Preparation of example 1

The invention provides a preparation for promoting digestion of animals and a preparation method thereof, which is characterized in that the formula of the raw materials in parts by weight is as follows: 6 parts of choerospondias axillaris, 3 parts of hawthorn extract, 6 parts of barley malt extract, 7 parts of radish seed extract, 6 parts of white hyacinth bean extract, 6 parts of coix seed extract, 2 parts of polydextrose, 10 parts of fructooligosaccharide, 22 parts of galacto-oligosaccharide, 175 parts of chicken liver powder, 58 parts of milk powder, 25 parts of egg yolk powder, 40 parts of amino acid, 20 parts of protein peptide, 900 parts of water and 2 parts of tea polyphenol.

Referring to fig. 1, the present invention also provides a preparation for promoting digestion of animals and a preparation method thereof, comprising the following steps:

s1, weighing the hawthorn extract, the barley malt extract, the radish seed extract, the white hyacinth bean extract, the coix seed extract, polydextrose, fructooligosaccharide, galacto-oligosaccharide, chicken liver powder, milk powder, yolk powder, amino acid and protein peptide according to the proportion, and mixing the raw materials;

s2, adding a proper amount of purified water into the mixed material obtained in the step S1, then weighing the choerospondias axillaries and the tea polyphenol according to the proportion, adding the materials, uniformly stirring the materials, controlling the speed at 23r/min, after the materials are uniformly stirred, adjusting the pH value to 4.6, adding a proper amount of purified water, and diluting the mixture to the viscosity of 400mPa.s to obtain a suspension oral liquid for later use;

s3, sleeving one end of the sterilized special conveying pipe to the port of a filling machine, and placing a 100ml clean glass bottle at the other end for canning;

s4, checking, weighing and capping the bottle-by-bottle products;

s5, sterilizing the rolled suspension oral liquid at high temperature of 121.3 ℃ under high pressure of 103.4kPa for 20min, cooling to room temperature, labeling and packaging to obtain the digestion-promoting suspension animal oral liquid of the traditional Chinese medicine composition.

Preparation of example 2

The invention provides a preparation for promoting digestion of animals and a preparation method thereof, wherein the preparation comprises the following raw materials in parts by weight: 30 parts of choerospondias axillaris, 10 parts of hawthorn extract, 12 parts of barley malt extract, 13 parts of radish seed extract, 10 parts of white hyacinth bean extract, 10 parts of coix seed extract, 6 parts of polydextrose, 15 parts of fructooligosaccharide, 28 parts of galacto-oligosaccharide, 185 parts of chicken powder, 68 parts of milk powder, 35 parts of egg yolk powder, 45 parts of amino acid, 25 parts of protein peptide, 1300 parts of water and 6 parts of lutein.

Referring to fig. 1, the present invention also provides a preparation for promoting digestion of animals and a preparation method thereof, comprising the following steps:

s1, weighing the hawthorn extract, the barley malt extract, the radish seed extract, the white hyacinth bean extract, the coix seed extract, polydextrose, fructooligosaccharide, galacto-oligosaccharide, chicken powder, milk powder, yolk powder, amino acid and protein peptide according to the proportion, and mixing the raw materials;

s2, adding a proper amount of purified water into the mixed material obtained in the step S1, then weighing the choerospondias axillaries and the lutein according to the proportion, adding the materials, uniformly stirring the materials, controlling the speed at 25r/min, adjusting the pH to 4.8 after the materials are uniformly stirred, and diluting the purified water to the viscosity of 450mPa.s to obtain a suspension oral liquid for later use;

s3, sleeving one end of the sterilized special conveying pipe to the port of a filling machine, and placing a 100ml clean glass bottle at the other end for canning;

s4, checking, weighing and capping the bottle-by-bottle products;

s5, sterilizing the rolled suspension oral liquid at high temperature of 121.3 ℃ under high pressure of 103.4kPa for 20min, cooling to room temperature, labeling and packaging to obtain the digestion-promoting suspension animal oral liquid of the traditional Chinese medicine composition.

Preparation of example 3

The invention provides a preparation for promoting digestion of animals and a preparation method thereof, wherein the preparation comprises the following raw materials in parts by weight: 60 parts of choerospondias axillaris, 20 parts of hawthorn extract, 20 parts of barley malt extract, 20 parts of radish seed extract, 20 parts of white hyacinth bean extract, 20 parts of coix seed extract, 10 parts of polydextrose, 20 parts of fructooligosaccharide, 32 parts of galacto-oligosaccharide, 200 parts of beef powder, 78 parts of milk powder, 55 parts of egg yolk powder, 50 parts of amino acid, 30 parts of protein peptide, 1800 parts of water and 10 parts of carotene.

Referring to fig. 1, the present invention also provides a preparation for promoting digestion of animals and a preparation method thereof, comprising the following steps:

s1, weighing the hawthorn extract, the barley malt extract, the radish seed extract, polydextrose, fructooligosaccharide, galacto-oligosaccharide, beef powder, milk powder, yolk powder, amino acid and protein peptide according to the proportion, and mixing the raw materials;

s2, adding a proper amount of purified water into the mixed material obtained in the step S1, then weighing the choerospondias axillaries and the carotene according to the proportion, adding the mixture, uniformly stirring the mixture at the speed of 27r/min, adjusting the pH value to 5.0 after uniformly stirring, and diluting the purified water to the viscosity of 500mPa.s to obtain a suspension oral liquid for later use;

s3, sleeving one end of the sterilized special conveying pipe to the port of a filling machine, and placing a 100ml clean glass bottle at the other end for canning;

s4, checking, weighing and capping the bottle-by-bottle products;

s5, sterilizing the rolled suspension oral liquid at high temperature of 121.3 ℃ under high pressure of 103.4kPa for 20min, cooling to room temperature, labeling and packaging to obtain the digestion-promoting suspension animal oral liquid of the traditional Chinese medicine composition.

Preparation of example 4

The invention provides a preparation for promoting digestion of animals and a preparation method thereof, wherein the preparation comprises the following raw materials in parts by weight: 60 parts of choerospondias axillaris, 20 parts of hawthorn extract, 20 parts of barley malt extract, 20 parts of radish seed extract, 20 parts of white hyacinth bean extract, 20 parts of coix seed extract, 10 parts of polydextrose, 20 parts of fructooligosaccharide, 32 parts of galacto-oligosaccharide, 200 parts of polypeptide fish meal, 78 parts of milk powder, 55 parts of egg yolk powder, 50 parts of amino acid, 30 parts of protein peptide, 1800 parts of water and 10 parts of curcumin.

Referring to fig. 1, the present invention also provides a preparation for promoting digestion of animals and a preparation method thereof, comprising the following steps:

s1, weighing the hawthorn extract, the barley malt extract, the radish seed extract, polydextrose, fructooligosaccharide, galactooligosaccharide, polypeptide fish meal, milk powder, yolk powder, amino acid and protein peptide according to the proportion, and mixing the raw materials;

s2, adding a proper amount of purified water into the mixed material obtained in the step S1, then weighing choerospondias axillaries and curcumin according to the proportion, adding the mixture, homogenizing and stirring, controlling the speed at 23r/min, after stirring uniformly, adjusting the pH to 4.6, and diluting the purified water to the viscosity of 500mPa.s to obtain a suspension oral liquid for later use;

s3, sleeving one end of the sterilized special conveying pipe to the port of a filling machine, and placing a 100ml clean glass bottle at the other end for canning;

s4, checking, weighing and capping the bottle-by-bottle products;

s5, sterilizing the rolled suspension oral liquid at high temperature of 121.3 ℃ under high pressure of 103.4kPa for 20min, cooling to room temperature, labeling and packaging to obtain the digestion-promoting suspension animal oral liquid of the traditional Chinese medicine composition.

Preparation of example 5

The invention provides a preparation for promoting digestion of animals and a preparation method thereof, wherein the preparation comprises the following raw materials in parts by weight: 30 parts of choerospondias axillaris, 20 parts of hawthorn extract, 6 parts of barley malt extract, 7 parts of radish seed extract, 20 parts of white hyacinth bean extract, 20 parts of coix seed extract, 10 parts of polydextrose, 20 parts of fructooligosaccharide, 32 parts of galacto-oligosaccharide, 250 parts of chicken liver powder, 78 parts of milk powder, 55 parts of egg yolk powder, 40 parts of amino acid, 20 parts of protein peptide, 1800 parts of water and 10 parts of curcumin.

Referring to fig. 1, the present invention also provides a preparation for promoting digestion of animals and a preparation method thereof, comprising the following steps:

s1, weighing the hawthorn extract, the barley malt extract, the radish seed extract, polydextrose, fructooligosaccharide, galactooligosaccharide, chicken liver powder, milk powder, yolk powder, amino acid and protein peptide according to the proportion, and mixing the raw materials;

s2, adding a proper amount of purified water into the mixed material obtained in the step S1, then weighing choerospondias axillaries and curcumin according to the proportion, adding the mixture, homogenizing and stirring, controlling the speed at 27r/min, after stirring uniformly, adjusting the pH to 5.0, and diluting the purified water to the viscosity of 480mPa.s to obtain a suspension oral liquid for later use;

s3, sleeving one end of the sterilized special conveying pipe to the port of a filling machine, and placing a 100ml clean glass bottle at the other end for canning;

s4, checking, weighing and capping the bottle-by-bottle products;

s5, sterilizing the rolled suspension oral liquid at high temperature of 125 ℃ and 120kPa for 30min, cooling to room temperature, labeling and packaging to obtain the digestion-promoting suspension animal oral liquid of the traditional Chinese medicine composition.

Preparation of example 6

The invention provides a preparation for promoting digestion of animals and a preparation method thereof, wherein the preparation comprises the following raw materials in parts by weight: 40 parts of choerospondias axillaris, 3 parts of hawthorn extract, 20 parts of barley malt extract, 20 parts of radish seed extract, 20 parts of white hyacinth bean extract, 6 parts of coix seed extract, 10 parts of polydextrose, 20 parts of fructooligosaccharide, 32 parts of galacto-oligosaccharide, 175 parts of chicken powder, 78 parts of milk powder, 30 parts of egg yolk powder, 50 parts of amino acid, 30 parts of protein peptide, 1800 parts of water and 10 parts of curcumin.

Referring to fig. 1, the present invention also provides a preparation for promoting digestion of animals and a preparation method thereof, comprising the following steps:

s1, weighing the hawthorn extract, the barley malt extract, the radish seed extract, polydextrose, fructooligosaccharide, galactooligosaccharide, chicken powder, milk powder, yolk powder, amino acid and protein peptide according to the proportion, and mixing the raw materials;

s2, adding a proper amount of purified water into the mixed material obtained in the step S1, then weighing choerospondias axillaries and curcumin according to the proportion, adding the mixture, homogenizing and stirring, controlling the speed at 27r/min, after stirring uniformly, adjusting the pH value to 4.8, and diluting the purified water to the viscosity of 490mPa.s to obtain a suspension oral liquid for later use;

s3, sleeving one end of the sterilized special conveying pipe to the port of a filling machine, and placing a 100ml clean glass bottle at the other end for canning;

s4, checking, weighing and capping the bottle-by-bottle products;

s5, sterilizing the rolled suspension oral liquid at high temperature of 121.3 ℃ under high pressure of 103.4kPa for 30min, cooling to room temperature, labeling and packaging to obtain the digestion-promoting suspension animal oral liquid of the traditional Chinese medicine composition.

Experiment of drug effect

Experiment one-Individual test

The separate test means that the test dogs and cats received the food of one of the oral suspension liquids prepared in preparation example 4 without any other preparation.

Number of experimental dogs: 20 dogs and cats of different ages

Wherein the amounts of the suspension oral liquid samples prepared in preparation example 4 provided for the test were: and (4) the cat: 5g, dog: 15 g.

Days of the experiment: 5 days

The experimental method comprises the following steps: and providing a food basin for the experimental dogs and cats at the same time, and placing a known amount of samples to be tested in the food basin. The amount of feed taken on the sample during one feeding session (9: 00-15: 00) was weighed and recorded.

And the feed intake (%) is the sample feed amount (g)/total sample supply amount (g). times.100% as shown in the formula

And calculating the feed intake rate.

Wherein: the food bowls are placed and exchanged every other day.

The results of the independent tests show that (see figure 2), the feed intake rate of the suspension oral liquid prepared by the preparation example 4 is more than 94%, and the recommended dosage in the specification can be basically eaten; but differences between the races cannot be determined from the feed intake results, palatability between the product and the races can be further tested by the first bite preference test.

Experiment two-first Port preference test

Meanwhile, two kinds of oral liquid are provided for experimental animals, and the animals are observed to eat which kind of oral liquid firstly in the first bite. This test is primarily directed to the first impression of the smell or appearance of food by the animal.

Number of experimental dogs: 20 dogs and cats of different ages

Wherein the amount of the suspension oral liquid sample prepared in preparation example 4 and the amount of the Haka khauso water P-O nutrient solution sample provided for the test are both: and (4) the cat: 5g, dog: 15 g.

Days of the experiment: five days

The experimental method comprises the following steps: two basins were provided for the test dogs and cats at the same time, each basin containing the same amount of different amounts of the suspended oral liquid, and the first choice of each test dog and cat was observed and recorded.

Wherein: the food bowls are placed and exchanged every other day.

The results are shown in Table 1.

Table 1 results of two suspension oral liquid animal palatability tests:

wherein: A. a suspension oral liquid prepared from preparation example 4 (without adding sodium carboxymethylcellulose); B. hai Jia local tyrant water P-O nutrient solution (with sodium carboxymethyl cellulose added).

As can be seen from table 1, in the feeding experiment lasting five days, the suspension oral liquid a prepared by preparation example 4 was selected for the first bite of most of the test dogs and cats; the feed intake of the oral suspension liquid prepared in preparation example 4 by dogs and cats is continuously higher than that of Hai coffee local tyrant water P-O nutrient solution B, and the consumption rate of the oral suspension liquid A prepared in preparation example 4 is stable for more than 93 percent, and the continuous feed intake is good. The first taste preference test result shows that the flavor presented by the suspension oral liquid A prepared in the preparation example 4 is the flavor which is liked by dogs and cats, which is probably caused by the unique flavor brought by the preparation containing the choerospondias axillaris fruit in a specific weight part ratio.

Experiment III-viscosity stability test

A sample of the suspension oral liquid was prepared according to preparation example 4, and its viscosity (25 ℃ C.) was measured.

Samples of the suspension formulation of the raw formulation of Geofur (self-developed by the Applicant company, Lilin Biotechnology Ltd.) were prepared and the viscosity (25 ℃) was measured.

After the two samples were sealed and allowed to stand for three months, their viscosities were measured again (15 ℃).

The results are shown in Table 2.

Table 2 viscosity test results for two kinds of oral suspensions

As can be seen from Table 2, the Choerospondias axillaris suspension formulation prepared by preparation example 4 was stable in viscosity for 3 months, and no matter whether the temperature was changed, it was revealed that the system was less affected by the ambient temperature. However, the viscosity of the galenical suspension oral preparation is obviously changed by temperature, and the stability is relatively low.

In the process of pouring the two preparation samples on white paper respectively, the invention discovers that: the choerospondias axillaris suspension preparation prepared in preparation example 4 is stable and uniform in liquid state after 3 months, good in fluidity and free from caking and lumping. However, the suspension formulation of the raw galenical formulation uses sodium carboxymethylcellulose as a thickening agent, the viscosity of the system is greatly changed by the influence of the ambient temperature, and the system also has the phenomenon of little caking unevenness under the condition of low ambient temperature, so that the viscosity of the suspension formulation is increased by reducing the indoor temperature by 10 ℃ within 3 months, and little caking particles exist, and the liquid state is uneven (as shown by arrows in fig. 3).

The embodiments of the present invention have been described in detail, and the principles and embodiments of the present invention are explained herein using specific examples, which are provided only to help understand the method and the core idea of the present invention. Meanwhile, those skilled in the art should also be able to make modifications or variations to the embodiments and applications of the present invention based on the idea of the present invention.

The present invention may be embodied in other specific forms without departing from its essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore, indicated by the appended claims rather than by the foregoing description. In view of the above, the present disclosure should not be construed as limiting the invention.

Claims (10)

1. The composition for promoting digestion of animals is characterized by comprising the following components in parts by weight: 6-60 parts of choerospondias axillaris, 3-20 parts of hawthorn extract, 6-20 parts of barley malt extract, 7-20 parts of radish seed extract, 6-20 parts of white hyacinth bean extract and 6-20 parts of coix seed extract.

2. The composition of claim 1, comprising, in parts by weight: about 60 parts of choerospondias axillaris, about 20 parts of hawthorn extract, about 20 parts of barley malt extract, about 20 parts of radish seed extract, about 20 parts of white hyacinth bean extract and about 20 parts of coix seed extract.

3. The composition of claim 1, wherein the composition further comprises one or more of: flavoring powder, water soluble cellulose, milk powder, yolk powder, amino acids and protein peptide;

preferably, the taste correcting powder is selected from one or more of the following: chicken liver powder, chicken meat powder, beef powder and polypeptide fish powder;

preferably, the water-soluble cellulose comprises polydextrose and/or oligosaccharide;

preferably, the amino acids are lysine and/or taurine;

more preferably, the oligosaccharide is selected from one or more of the following: fructo-oligosaccharide, isomalto-oligosaccharide, lacto-oligosaccharide, mannose-oligosaccharide, soybean oligosaccharide, chitosan oligosaccharide, xylo-oligosaccharide and galacto-oligosaccharide;

more preferably, the composition further comprises, in parts by weight: 250 parts of flavor correcting powder 175, 34-80 parts of water-soluble cellulose, 58-100 parts of milk powder, 25-80 parts of yolk powder, 40-70 parts of amino acid and 20-40 parts of protein peptide;

still more preferably, the composition further comprises, in parts by weight: 200 parts of flavor correcting powder 175-one, 34-62 parts of water-soluble cellulose, 58-78 parts of milk powder, 25-55 parts of yolk powder, 40-50 parts of amino acid and 20-30 parts of protein peptide;

still particularly preferably, the composition further comprises, in parts by weight: 200 parts of flavor correcting powder, 62 parts of water-soluble cellulose, 78 parts of milk powder, 55 parts of yolk powder, 50 parts of amino acid and 30 parts of protein peptide;

even more particularly preferably, the composition further comprises a nutritional additive;

even more particularly preferably, the nutritional additive is a vitamin and/or a trace element;

particularly preferably, the composition does not include an antibiotic;

still particularly preferably, the composition does not comprise a hormone.

4. The composition according to any one of claims 1 to 3, wherein the animal is a mammal, such as a human;

preferably, the animal is a pet;

still preferably, the pet is a cat, dog, mouse or rabbit.

5. A formulation comprising the composition of any one of claims 1 to 4, wherein the formulation further comprises an adjuvant;

preferably, the formulation is an oral liquid, a lotion, an ointment or a plaster;

still preferably, the adjuvants include antioxidants, preservatives, sweeteners and/or PH regulators.

6. The formulation of claim 5, wherein the antioxidant is selected from one or more of the following: tea polyphenols, lutein, carotene and curcumin;

preferably, the preservative is sodium benzoate;

preferably, the sweetener is sucrose;

preferably, the PH adjusting agent is citric acid.

7. The formulation of claim 5 or 6, wherein the adjuvant does not include a thickening agent;

preferably, the thickener is selected from one or more of the following: sodium carboxymethylcellulose, gelatin and agar.

8. Use of a composition according to any one of claims 1 to 4 or a formulation according to any one of claims 5 to 7 for the preparation of animal medicaments, foods and nutraceuticals for the prevention and/or treatment of dyspepsia, anorexia.

9. A method of preparing the formulation of any one of claims 5 to 7, comprising the steps of:

1) weighing appropriate amount of fructus crataegi extract, fructus Hordei Germinatus extract, Raphani semen extract, semen lablab album extract, Coicis semen extract, water soluble cellulose, flavoring powder, milk powder, yolk powder, amino acids, and protein peptide, and mixing to obtain a first mixture;

2) adding a proper amount of water to the first mixture to obtain a second mixture;

3) weighing a proper amount of choerospondias axillaris and an antioxidant according to the proportion, adding the choerospondias axillaris and the antioxidant into the second mixture, and homogenizing and stirring to obtain a third mixture;

4) adding a proper amount of preservative, sweetener, pH regulator and water into the third mixture, and regulating the pH value to be 4.6-5.0 and the viscosity to be 400-500mPa.s to obtain a fourth mixture; and

5) and sterilizing the fourth mixture for 10-60 min under the conditions of 0.1-0.36 MPa and high temperature and high pressure of 100-140 ℃, and cooling to room temperature to obtain the preparation.

10. The method of claim 9, wherein the speed of the homogeneous agitation is 23-27 r/min;

preferably, the temperature of the homogeneous stirring is controlled in the range of 40 ℃ to 50 ℃;

preferably, the fourth mixture is sterilized at about 103.4kPa at about 121.3 ℃ for about 20 min.

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