CN114113595B - Virus extraction and storage integrated detection tube and application method thereof - Google Patents
Virus extraction and storage integrated detection tube and application method thereof Download PDFInfo
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- CN114113595B CN114113595B CN202111429604.4A CN202111429604A CN114113595B CN 114113595 B CN114113595 B CN 114113595B CN 202111429604 A CN202111429604 A CN 202111429604A CN 114113595 B CN114113595 B CN 114113595B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
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Abstract
The invention discloses a virus extraction and storage integrated detection tube and an application method thereof, wherein the detection tube comprises a tube body, an upper cover, a lower cover, a detection reagent strip and a rubber sealing gasket, the upper cover is installed at the upper end of the tube body, the lower cover is installed at the lower end of the tube body, a thimble structure is arranged at the center of the lower cover, a platform protruding from the wall of a circular tube is arranged outside the tube body, and retrospective information is arranged on the platform; the pipe body is characterized in that a pair of cavity structures which are isolated from each other in a back direction are arranged on the parallel pipe wall in the pipe body and are a first cavity and a second cavity, the upper port of the first cavity is sealed, the lower port of the first cavity is provided with a conical guide groove, the lower port of the second cavity is sealed, and the upper port of the second cavity is an opening. The invention integrates the functional steps of virus sampling, extraction, storage, detection, tracing and the like.
Description
Technical Field
The invention belongs to the field of virus detection, and particularly relates to a virus extraction and storage integrated detection tube and an application method thereof.
Background
Currently, in the application of rapid/real-time virus collection and detection, typical manual operation processes such as traditional manual sample adding, extraction, detection, recovery and the like are generally adopted. In a typical operation scenario, such as home self-test of virus, a user needs to use a swab to obtain a virus vector sample, add the virus vector sample into an independent liquid extraction tube to perform extraction and dilution, and then inject the diluted sample into a detection device (such as a lateral flow chromatography reagent card) to perform a reaction and obtain a detection result. After the detection is finished, the user needs to uniformly collect disposable parts, consumables, biological waste materials and the like used in the detection process into the sealed packaging bag for recycling.
The operation processes are all realized by manual operation, the steps are complicated, the error detection is easily caused by external pollution introduction caused by misoperation, or the secondary propagation or the environment pollution is caused by virus leakage caused by improper prevention in the operation, part transferring and recycling processes.
Disclosure of Invention
Aiming at the problems, the invention provides an integrated detection tube and an application method thereof, so as to solve the problems of complex and complicated manual operation, various parts and low biological safety in the prior art and realize the purpose of integrating the functional steps of virus sampling, extraction, storage, detection, tracing and the like.
In order to achieve the purpose, on one hand, the invention discloses a virus extraction and storage integrated detection tube, which adopts the following technical scheme:
a virus extraction and storage integrated detection tube comprises a tube body, an upper cover, a lower cover, a detection reagent strip and a rubber sealing gasket, wherein the upper cover is installed at the upper end of the tube body, the lower cover is installed at the lower end of the tube body, a thimble structure is arranged at the center of the lower cover, a platform protruding out of the circular tube wall is arranged outside the tube body, and retrospective information is arranged on the platform;
the inner parallel pipe wall of the pipe body is provided with a pair of cavity structures which are isolated from each other in a back-to-back mode and are a first cavity and a second cavity, the upper end opening of the first cavity is closed, the lower end opening of the first cavity is provided with a conical guide groove, and the first cavity is used for loading a detection reagent clamping strip from the lower end opening to the upper end; the lower port of the second cavity is closed, the upper port of the second cavity is open, and the second cavity is used for filling reagent liquid from top to bottom from the upper port;
the cavity structures of the first cavity and the second cavity are positioned above the first cavity and the second cavity, and are in interference fit with the inner wall of the pipe body through injection welding or sealing pieces, so that a sealing structure is formed with the inner wall of the pipe body, the cavity structures of the first cavity and the second cavity are fixed in the pipe body, and the second cavity is arranged in the pipe body in the middle.
Further, the outer wall of the upper end opening of the pipe body is a locking device, the upper cover is locked with the upper end of the pipe body through the locking device, two convex edges which are vertically parallel and adjacent and are continuously or discontinuously distributed along the annular wall of the outer pipe are arranged on the outer wall of the opening at the lower end of the pipe body, and one or more positioning sheath bodies are arranged above the convex edges.
Furthermore, the upper cover is of a cover structure, the inner wall of the upper cover is provided with a locking device, and the inner part of the upper cover is provided with a lining tongue structure which is used for extending into the pipe body and forming interference fit with the inner wall of the pipe body to realize the sealing effect.
Furthermore, the lower cover is of a cover structure, the inner side of the cover opening of the lower cover is provided with a convex edge which is continuously or discontinuously distributed along the annular wall, and the edge of the cover opening of the lower cover is provided with one or more positioning grooves.
Furthermore, the first cavity can be set as a plurality of spaced cavities, arranged in a manner of surrounding the periphery of the second cavity, and used for mounting a plurality of detection reagent card strips.
Furthermore, two protruding structures are arranged on the inner wall of the second cavity, and a diaphragm is arranged at the closed position of the lower port of the second cavity.
Furthermore, a puncturing device is arranged at the top of the thimble structure of the lower cover, a flow guide groove is arranged on the surface of the thimble structure, the middle of the thimble structure is a table body, a supporting table is arranged at the bottom of the thimble structure, and a rubber sealing pad is further arranged at the bottom of the thimble structure.
Furthermore, the detection reagent card strip is a lateral chromatography reagent strip, and the size, the size and the shape of the detection reagent card strip are matched with the space of the first cavity.
Furthermore, a convex ring-shaped piece is arranged at an opening at the upper part of the rubber sealing gasket, and one or more ring-shaped sealing components are arranged outside the rubber sealing gasket.
On the other hand, the invention discloses an application method of the virus extraction and storage integrated detection tube, which comprises the following steps:
step S1, pre-filling the reagent liquid of the integrated detection tube into a second cavity;
step S2, taking a sample by the swab, opening the upper cover, and putting the taken swab into the second cavity without taking the swab out;
step S3, turning back the upper cover, vertically placing the integrated detection tube and waiting for the sample to be dissolved/cracked to obtain related biological components;
step S4, after the relevant biological components are formed, rotating the lower cover to match the position of the positioning sheath body of the convex edge of the tube body with the positioning groove of the lower cover, then pressing the lower cover from bottom to top, wherein the positioning sheath body enters the positioning groove, and meanwhile, the ejector pin structure of the lower cover punctures the diaphragm of the second cavity to make the reagent liquid carrying the relevant biological components flow out and automatically contact with the detection reagent clamping strip to start detection;
step S5, after the detection is finished, the intelligent terminal can be selected to photograph the retrospective information on the platform of the integrated detection tube body, and the retrospective information is uploaded to a specific digital platform;
and step S6, after all detection actions are finished, the integrated detection tube is integrally recovered.
Compared with the prior art, the invention has the beneficial effects that: the invention provides an integrated detection tube design, which integrates the functional steps of virus sampling, extraction, storage, detection, tracing and the like, and when the detection is carried out, a user only executes the steps of sample extraction and tube placement to quickly start the detection without the actions of part arrangement, sample adding, liquid transferring, regular recovery and the like in the traditional scheme. Because the integrated detection tube has reliable sealing performance, the risk of leakage of biological pollutants can be reliably eliminated after detection neutralization; secondly, the invention simplifies the manual operation of users, reduces the number of parts, size and space volume, improves the key product efficiency of recovery convenience, biological safety, material environmental protection, detection result traceability and the like, and ensures the manufacturing lean and the automation feasibility.
Drawings
FIG. 1 is an overall view of the integrated detector tube of the present invention;
FIG. 2 is a schematic view of the tube body structure of the integrated detection tube of the present invention;
FIG. 3 is a side view of the body of the integrated detector tube of the present invention;
FIG. 4 is a rear view of the body of the integrated detector tube of the present invention;
FIG. 5 is a detailed view of the inner wall of the second chamber of the integrated detector tube of the present invention
FIG. 6 is a detail view of the lower end of the second chamber of the integrated detector tube of the present invention;
FIG. 7 is a schematic view of a sealing structure of the cavity of the integrated detection tube according to the present invention;
FIG. 8 is a schematic structural diagram of the upper cover of the integrated detection tube of the present invention;
FIG. 9 is a schematic structural view of a lower cover of the integrated detection tube of the present invention;
FIG. 10 is a schematic view showing the structure of a test reagent card strip of the integrated test tube of the present invention;
FIG. 11 is a schematic view of a rubber gasket structure of the integrated detector tube of the present invention;
reference numerals: 1. a tube body; 1.1, a thread device; 1.2, a circular conical convex edge; 1.3, positioning a sheath body; 1.4, a platform; 1.5, a first cavity; 1.6, a second cavity; 1.6.1, a convex structure; 1.6.2, a diaphragm; 1.6.3, sealing structure; 2. an upper cover; 2.1, lining tongue structure; 3. a lower cover; 3.1, a cylindrical thimble; 3.2, a frustum; 3.3, knurling a cylinder; 3.4, a conical convex edge piece; 3.5, positioning a groove; 4. detecting a reagent card strip; 5. a rubber gasket; 5.1, a convex ring-shaped piece; 5.2, ring-shaped sealing component.
Detailed Description
The invention is explained in further detail below with reference to the drawings and the embodiments.
As shown in fig. 1, the invention discloses a virus extraction and storage integrated detection tube, which specifically comprises a tube body 1, an upper cover 2, a lower cover 3, a detection reagent card strip 4 and a rubber gasket 5, wherein the upper cover 2 is installed at the upper end of the tube body 1, the lower cover 3 is installed at the lower end of the tube body 1, a thimble structure, preferably a cylindrical thimble 3.1, is arranged at the center of the lower cover 3, a platform 1.4 protruding from the circular tube wall is arranged outside the tube body 1, the platform 1.4 is used for deploying traceability information such as bar codes and characters, the platform 1.4 can be in any shape, such as rectangle or circle, and the traceability information is preferably a two-dimensional code.
As shown in fig. 2, the outer wall of the opening at the upper end of the tube body 1 is provided with a locking device for installing the upper cover 2 and matching with the upper cover to realize locking, specifically, as a thread device 1.1, the upper cover 2 is screwed into the upper end of the tube body 1 through the thread device 1.1, two vertically parallel and adjacent convex edges with specific shapes continuously or discontinuously distributed along the outer tube ring wall are arranged on the outer wall of the opening at the lower end of the tube body 1, preferably, an annular tapered convex edge 1.2 is arranged, and the annular tapered convex edge 1.2 is used for matching with the lower cover 3 to form a staged interlocking mechanism. One or more positioning sheaths 1.3 are arranged above the annular conical convex edge 1.2, and the positioning sheaths 1.3 are used for matching with the lower cover 3 to limit the stroke of the lower cover 3 pressed into the tube body 1 in a staged manner.
Fig. 8 shows that the upper cover 2 is a cover structure, and the inner wall thereof may be provided with a specific locking device, preferably a screw cap, for cooperating with the tube 1 to achieve locking. The inner part of the pipe body is also provided with a lining tongue structure 2.1 which is used for extending into the pipe body 1 and forming interference fit with the inner wall of the pipe body 1 to realize sealing effect.
As shown in fig. 9, the lower cap 3 is a cover structure, preferably a press-in cover, and the inside of the cap opening of the lower cap 3 is provided with specific-shaped protruding rims, preferably tapered protruding rim members 3.4 spaced or continuous with each other, continuously or intermittently distributed along the annular wall, for forming an interlocking structure cooperating with the annular tapered protruding rim 1.2 of the tube body 1. One or more positioning grooves 3.5 are arranged at the edge of the cover opening of the lower cover 3 and are used for forming a limiting mechanism which is mutually matched with the positioning sheath body 1.3 to limit the stroke of pressing the lower cover 3 into the pipe body 1.
As shown in fig. 3, a pair of cavity structures isolated from each other in a back direction are arranged on the parallel tube wall inside the tube body 1, and are a first cavity 1.5 and a second cavity 1.6, wherein the upper port of the first cavity 1.5 is closed, a tapered guide groove is arranged at the lower port of the first cavity 1.5, the first cavity 1.5 is used for loading the detection reagent card strip 4 from the lower port to the upper port, and the tapered guide groove is used for assisting the self-positioning and smooth loading of the detection reagent card strip 4.
The lower port of the second cavity 1.6 is closed, the upper port of the second cavity 1.6 is open, the second cavity 1.6 is used for loading reagent liquid from the upper port from top to bottom, and the second cavity 1.6 is arranged in the middle of the tube body 1 and is used for matching with the lower cover 3 to realize corresponding action. As shown in fig. 4-5, two protruding structures 1.6.1 are provided on the inner wall of the second cavity 1.6 for scraping more sample from the swab head when the swab is put in. As shown in fig. 6, a sealing portion of the lower port of the second cavity 1.6 is a membrane 1.6.2, which can be punctured by the cylindrical thimble 3.1 of the lower cover 3 during use, so as to guide the flow of the sample.
As shown in fig. 7, the cavity structures of the first cavity 1.5 and the second cavity 1.6 are, at the upper position thereof, welded to the inner wall of the tube body by injection molding or in interference fit with a sealing member through the joint edge surface of the first cavity 1.5 and the second cavity 1.6, so as to form a sealing structure, and at the same time, the cavity structures of the first cavity and the second cavity are fixed in the tube body 1, and the second cavity is centrally disposed in the tube body, wherein the sealing member is preferably a rubber ring; and the opening and closing ports of the first cavity 1.5 and the second cavity 1.6 are inverted, and the contents of the first cavity 1.5 and the second cavity 1.6 are isolated from each other and cannot be contacted. First cavity 1.5 can expand into a plurality of spaced cavitys according to the application needs, can arrange in the mode of surrounding second cavity 1.6 periphery for a plurality of detection reagent card strips 4 of installation realize many detected items going on simultaneously.
Wherein the top of the thimble structure is provided with a puncturing device, preferably a cross-shaped wedge-shaped structure, for puncturing the diaphragm 1.6.2 of the second cavity 1.6 upwards by pressing in use, and the thimble structure is preferably a cylindrical thimble 3.1. The surface of the cylindrical thimble 3.1 is provided with a flow guide groove, and the flow guide groove is preferably a concave channel, so that when the diaphragm 1.6.2 is burst, the reagent liquid contained in the second cavity 1.6 can smoothly flow out. The middle part of the cylindrical thimble 3.1 is a frustum, preferably a frustum 3.2, for forming a contact sealing function with the rubber sealing gasket 5. The bottom of the cylindrical thimble 3.1 is a supporting table, preferably a knurled cylinder 3.3, and is used for supporting the installation of the rubber sealing gasket 5; the cylindrical thimble is also sleeved with a rubber gasket 5.
Referring to fig. 10, the detection reagent card strip 4 is a lateral chromatography reagent strip or other detection component for interacting with liquid to achieve detection, and the size and shape of the detection reagent card strip 4 are matched with the space of the first cavity 1.5.
Referring to fig. 11, a convex ring-shaped member 5.1 is provided at an upper opening of the rubber packing 5 of the present invention, for cooperating with the frustum 3.2 to achieve a sealing function. One or more ring-shaped sealing components are arranged outside the rubber sealing gasket 5 and are used for realizing the sealing effect by contacting with the inner wall of the tube body 1 without causing excessive friction force to prevent the lower cover 3 from smoothly interacting with the tube body 1.
On the other hand, the invention discloses an application method of a virus extraction and storage integrated detection tube, which comprises the following steps:
step S1, the reagent liquid of the integrated detection tube is pre-filled in a second cavity 1.6;
step S2, the swab takes the sample, and after the upper cover 2 is opened, the taken swab is put into the second cavity 1.6 without being taken out;
step S3, turning back the upper cover 2, vertically placing the integrated detection tube and waiting for the sample to be dissolved/cracked to obtain the related biological components;
step S4, after the relevant biological components are formed, the lower cover 3 is rotated to enable the annular conical convex edge 1.2 of the tube body 1 to be matched with the positioning groove 3.5 of the lower cover 3 in position, then the lower cover 3 is pressed from bottom to top, the positioning sheath 1.3 enters the positioning groove 3.5, meanwhile, the cylindrical thimble 3.1 of the lower cover 3 punctures the diaphragm 1.6.2 of the second cavity 1.6, so that the reagent liquid flows out with the relevant biological components and automatically contacts with the detection reagent card strip 4, and the detection is started;
and step S5, after the detection is finished, the user can choose to use an intelligent terminal, such as a smart phone, to photograph the two-dimensional code on the platform 1.4 of the tube body 1 of the integrated detection tube and upload the two-dimensional code to a specific digital platform. Because the two-dimensional code boss is designed to be coplanar with the detection reagent strip, the shot image can realize the digital identification, anti-counterfeiting and acquisition of the detection result and the ID of the user detection tube;
and step S6, after all detection actions are finished, the integrated detection tube is integrally recovered.
In the invention, a user can quickly start detection only by executing the steps of sample extraction and placing into a tube without performing the actions of part arrangement, sample adding, liquid transferring, regular recovery and the like in the traditional scheme. Because the integrated detection tube has reliable sealing performance, the risk of leakage of biological pollutants can be reliably eliminated during and after detection.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (8)
1. A virus extraction and storage integrated detection tube comprises a tube body (1), an upper cover (2), a lower cover (3), a detection reagent clamping strip (4) and a rubber sealing gasket (5), wherein the upper cover (2) is installed at the upper end of the tube body (1), and the lower cover (3) is installed at the lower end of the tube body (1), and is characterized in that a thimble structure is arranged at the center of the lower cover (3), a platform (1.4) protruding from a circular tube wall is arranged outside the tube body (1), and retrospective information is arranged on the platform (1.4);
a pair of cavity structures which are isolated from each other in a back direction are arranged on the inner parallel pipe wall of the pipe body (1) and are a first cavity (1.5) and a second cavity (1.6), the upper end opening of the first cavity (1.5) is closed, the lower end opening of the first cavity (1.5) is provided with a conical guide groove, and the first cavity (1.5) is used for loading a detection reagent clamping strip (4) from the lower end opening to the upper part; the lower port of the second cavity (1.6) is closed, the upper port of the second cavity (1.6) is open, and the second cavity (1.6) is used for filling reagent liquid from top to bottom from the upper port;
the cavity structures of the first cavity (1.5) and the second cavity (1.6) are in interference fit with the inner wall of the pipe body (1) through injection molding welding or a sealing element at the upper position of the cavity structures, and a sealing structure (1.6.3) is formed on the inner wall of the pipe body (1) through the combined edge surface of the first cavity (1.5) and the second cavity (1.6), so that the cavity structures of the first cavity (1.5) and the second cavity (1.6) are fixed in the pipe body (1), and the second cavity (1.6) is arranged in the middle of the pipe body (1);
the top of the thimble structure of the lower cover (3) is provided with a puncture device, the surface of the thimble structure is provided with a diversion trench, the middle of the thimble structure is a table body, the bottom of the thimble structure is a supporting table, and the thimble structure is further sleeved with a rubber sealing gasket (5).
2. The integrated detection tube for virus extraction and preservation according to claim 1, wherein the outer wall of the opening at the upper end of the tube body (1) is a locking device, the upper cover (2) is locked with the upper end of the tube body (1) through the locking device, two vertically parallel and adjacent convex edges continuously or discontinuously distributed along the annular wall of the outer tube are arranged on the outer wall of the opening at the lower end of the tube body (1), and one or more positioning sheath bodies (1.3) are arranged above the convex edges.
3. The integrated virus extraction and storage detection tube as claimed in claim 1, wherein the upper cover (2) is of a covering structure, the inner wall of the upper cover is provided with a locking device, and the inner part of the upper cover is further provided with a lining tongue structure (2.1) which is used for extending into the tube body (1) and forms an interference fit with the inner wall of the tube body (1) to realize a sealing effect.
4. The integrated detection tube for virus extraction and preservation according to claim 1, wherein the lower cover (3) is of a covering structure, the inner side of the opening of the lower cover (3) is provided with a convex edge continuously or intermittently distributed along the annular wall, and the edge of the opening of the lower cover (3) is provided with one or more positioning grooves (3.5).
5. The integrated virus extraction and storage detection tube according to claim 1, wherein the first cavity (1.5) is further configured as a plurality of spaced cavities arranged around the periphery of the second cavity (1.6) for mounting a plurality of detection reagent card strips (4).
6. The integrated detection tube for virus extraction and preservation according to claim 1, wherein the inner wall of the second cavity (1.6) is provided with two protruding structures (1.6.1), and the closed position of the lower port of the second cavity (1.6) is a diaphragm (1.6.2).
7. The integrated detection tube for virus extraction and preservation according to claim 1, wherein the detection reagent card strip (4) is a lateral chromatography reagent strip, and the size, the size and the shape of the detection reagent card strip (4) are matched with the space of the first cavity (1.5).
8. The integrated detecting tube for virus extraction and preservation according to claim 1, characterized in that the opening at the upper part of the rubber gasket (5) is provided with a convex ring-shaped member (5.1), and the outside of the rubber gasket (5) is provided with one or more ring-shaped sealing components (5.2).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111429604.4A CN114113595B (en) | 2021-11-29 | 2021-11-29 | Virus extraction and storage integrated detection tube and application method thereof |
| PCT/CN2022/081492 WO2023092904A1 (en) | 2021-11-29 | 2022-03-17 | Virus extraction and preservation integrated detection tube and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111429604.4A CN114113595B (en) | 2021-11-29 | 2021-11-29 | Virus extraction and storage integrated detection tube and application method thereof |
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| CN114113595A CN114113595A (en) | 2022-03-01 |
| CN114113595B true CN114113595B (en) | 2022-05-20 |
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| CN114113595B (en) * | 2021-11-29 | 2022-05-20 | 厦门宝太生物科技股份有限公司 | Virus extraction and storage integrated detection tube and application method thereof |
| CN114578045A (en) * | 2022-03-22 | 2022-06-03 | 中元汇吉生物技术股份有限公司 | Integrated reaction detection tube and packaging method, use method and application thereof |
| CN115267175A (en) * | 2022-07-05 | 2022-11-01 | 杭州莱和生物技术有限公司 | Integrated medical detector |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869003A (en) * | 1998-04-15 | 1999-02-09 | Nason; Frederic L. | Self contained diagnostic test unit |
| WO2016188096A1 (en) * | 2015-05-27 | 2016-12-01 | Abon Biopharm(Hangzhou) Co. Ltd. | A mixing device |
| CN111876323A (en) * | 2020-08-25 | 2020-11-03 | 东莞岩水科技发展有限公司 | Virus sampling, storing and detecting composite tube and using method thereof |
| CN212476731U (en) * | 2020-03-16 | 2021-02-05 | 华中科技大学同济医学院附属协和医院 | Disposable virus sampling tube |
| CN212489977U (en) * | 2020-05-11 | 2021-02-09 | 中山大学达安基因股份有限公司 | Storage tube for sampling swab |
| CN212864773U (en) * | 2020-08-25 | 2021-04-02 | 东莞岩水科技发展有限公司 | Virus sampling, storing and detecting composite tube |
| CN214278200U (en) * | 2020-12-10 | 2021-09-24 | 东莞岩水科技发展有限公司 | Fully-sealed prepressing sampling, storing and detecting integrated medical tube |
| WO2021209755A1 (en) * | 2020-04-15 | 2021-10-21 | Bjs Ip Ltd | A cap for a pathogen sample tube |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102252871B (en) * | 2011-07-05 | 2014-12-17 | 浙江拱东医疗科技有限公司 | One-time conveying sampler |
| CN114113595B (en) * | 2021-11-29 | 2022-05-20 | 厦门宝太生物科技股份有限公司 | Virus extraction and storage integrated detection tube and application method thereof |
-
2021
- 2021-11-29 CN CN202111429604.4A patent/CN114113595B/en active Active
-
2022
- 2022-03-17 WO PCT/CN2022/081492 patent/WO2023092904A1/en unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869003A (en) * | 1998-04-15 | 1999-02-09 | Nason; Frederic L. | Self contained diagnostic test unit |
| WO2016188096A1 (en) * | 2015-05-27 | 2016-12-01 | Abon Biopharm(Hangzhou) Co. Ltd. | A mixing device |
| CN212476731U (en) * | 2020-03-16 | 2021-02-05 | 华中科技大学同济医学院附属协和医院 | Disposable virus sampling tube |
| WO2021209755A1 (en) * | 2020-04-15 | 2021-10-21 | Bjs Ip Ltd | A cap for a pathogen sample tube |
| CN212489977U (en) * | 2020-05-11 | 2021-02-09 | 中山大学达安基因股份有限公司 | Storage tube for sampling swab |
| CN111876323A (en) * | 2020-08-25 | 2020-11-03 | 东莞岩水科技发展有限公司 | Virus sampling, storing and detecting composite tube and using method thereof |
| CN212864773U (en) * | 2020-08-25 | 2021-04-02 | 东莞岩水科技发展有限公司 | Virus sampling, storing and detecting composite tube |
| CN214278200U (en) * | 2020-12-10 | 2021-09-24 | 东莞岩水科技发展有限公司 | Fully-sealed prepressing sampling, storing and detecting integrated medical tube |
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| Publication number | Publication date |
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| CN114113595A (en) | 2022-03-01 |
| WO2023092904A1 (en) | 2023-06-01 |
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