CN104697811A - Sample collection apparatus and method thereof - Google Patents
Sample collection apparatus and method thereof Download PDFInfo
- Publication number
- CN104697811A CN104697811A CN201310651785.4A CN201310651785A CN104697811A CN 104697811 A CN104697811 A CN 104697811A CN 201310651785 A CN201310651785 A CN 201310651785A CN 104697811 A CN104697811 A CN 104697811A
- Authority
- CN
- China
- Prior art keywords
- cavity
- lid
- gatherer
- sample
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a sample collection apparatus, which comprises a sample collector, wherein a sealing chamber is arranged on the collector. Through the collection apparatus, a buffer solution is fully mixed with a sample, the collection apparatus especially aims at detection of a sample needing pretreatment, and the smooth completion of detection can be ensured.
Description
Technical field
The present invention relates to a kind of apparatus and method of collecting sample, particularly to collect after sample and the apparatus and method of pre-service sample.
Background technology
Background technology below for helping reader understanding the present invention, and can not be considered to prior art.
In our society, illicit drug use has become one and has generally acknowledged and the social concern increasingly worsened.2003, U.S. Department of Health and Human Service investigation found about have 1,950 ten thousand Americans or the crowd of 8.2% age more than 12 years old to suck illicit drugs." use illicit drugs recently " and refer to carry out investigating in the previous moon at U.S. Department of Health and Human Service and use a kind of illicit drugs.Hemp is found to be the most frequently used illicit drugs, accounts for 6.2% (1,460 ten thousand).Estimate that 2,300,000 people (1.0%) use cocaine, 604 now, 000 people employs crack, and have 1,000,000 people to use psychedelic, and estimate 119,000 people uses heroin.
US Patent No. 2004/0184954 and US2004/0237674 disclose other and collect saliva and carry out detecting the device whether containing illicit drugs composition in saliva.In these two patents, both provide the apparatus and method of collecting and detecting saliva, in these devices, when sample is sampled after on gatherer, by applying external force, the sample in absorption piece on gatherer is expressed in collecting chamber, and then detects.But applicator is coordinating in extrusion process with collecting chamber, sample contact may had and polluting to operator or infect; Further, when running into sample and needing first and detect after damping fluid mixing again, such gathering-device just seems not very convenient.
In addition, in some detect, sample needs to carry out process and crosses and can be detected.Such as, add buffer solution in the sample, make sample be diluted to reduce viscosity, ensure that sample can dialysis etc. smoothly on detector bar.Buffer solution how can be made to mix smoothly with sample, mixing fully and handled easily be all the problem needing to solve.
During other detect, in order to ensure the accuracy detected, needing detected sample size to be quantitative, detection can not be completed to prevent very few sample size and too much sample size can produce Flooding phenomenon, affect the accuracy of testing result.
Therefore better method and apparatus is needed to collect sample and detect.
Summary of the invention
A kind of sample collection device provided by the invention, comprises applicator, wherein, gatherer has seal chamber.
Preferably, seal chamber can be connected by channel liquid with the absorber element on gatherer.
Preferably, this device also comprises a lid, and lid and gatherer form the seal chamber on gatherer.
Preferably, lid and gatherer are detachable connection.
Preferably, lid and gatherer to be coordinated with the through hole of lid by the movable element on gatherer and achieve a fixed connection and be separated.
Preferably, when being positioned at the hole on lid when movable element, lid is fixedly connected with gatherer; When movable element departs from the hole on lid, can rotate between lid and gatherer.
Preferably, by the movement between lid and gatherer, the volume of seal chamber is made to reduce or increase.
Preferably, by the movement between lid and gatherer, seal chamber is connected by passage with the absorber element of gatherer.
Preferably, described passage comprises the collection bar of hollow, and collect bar one end and connect absorber element, the other end is sealed and connects seal chamber.
Preferably, poking by the projection in seal chamber the diaphragm seal collecting masthead end makes the collection bar of seal chamber and hollow and absorber element be communicated with.In a specific embodiment, projection is positioned at the inner tip of lid, is positioned at seal chamber simultaneously.
Preferably, in seal chamber, there is buffer solution.
In addition, the present invention also provides a kind of device, gathering-device provided by the invention, also comprises the first cavity and the second cavity, and wherein, the first cavity is positioned at the second cavity; Described first cavity can seal the second cavity; Further, the first cavity can compress the second cavity and makes the liquid in the second cavity by quantitative discharge.
This device can realize quantitative sample and enter in detecting element, and solution sample size is too much or the very few testing result caused is incorrect or inaccurate; Meanwhile, this device is also applicable to sample needs pretreated detection.
Preferably, the first cavity and the second cavity are for being flexibly connected.Preferably, when the first cavity is fixedly connected with the second cavity, the second cavity is not sealed; After the first cavity is separated with the second cavity, the second cavity is by the first cavity sealing and compression.
Preferably, after the first cavity is separated with the second cavity, can movement mutually between the first cavity and the second cavity.
Preferably, the first cavity has primary importance and the second place on the second cavity.Preferably, when the first cavity is positioned at primary importance, the first cavity seals the second cavity, forms the cavity of sealing.Preferably, when the first cavity is positioned at the second place, the cavity of sealing is compressed by the first cavity, and the liquid in seal chamber is quantitatively discharged.
Specifically, when sample is not collected, for being fixedly connected with between two cavitys, facilitate the collection of liquid sample; And when sample is collected into after in the first cavity and the second cavity, by the change of position between the first cavity and the second cavity, namely the first cavity rotates on the second cavity, liquid is sealed in the second cavity, compressed, be finally discharged the second cavity again, realized the function of quantitative sample injection.Specifically, after two cavitys disengagings are fixedly connected with, first rotate the first cavity and make it lower mobile mutually along the second inside cavity, when arriving first position, by the second cavity sealing; More specifically, have a little cavity at the second cavity bottom, the first cavity, by this little cavity sealing, forms the cavity of the sealing of an accommodation sample.Rotate the second place of the first cavity to the second cavity again, then, the first cavity continues to move down, and the little cavity volume of sealing is compressed, and is wherein then discharged the liquid of respective amount according to the size of volume compression by the sample sealed.Because the spacing of primary importance to the second place is fixed, so being fixed by the volume size compressed of cavity of sealing, thus the amount of liquid got rid of also is fixing, thus the quantitative sample of specific implementation is discharged, and realizes the function of quantitative sample injection.
Preferably, two cavitys are made to be fixedly connected with and to be separated by the first projection of rib on the first cavity and the connection of the through hole of the second cavity with being separated.
Preferably, this device also comprises test chamber, and test chamber is connected with the seal chamber of the second cavity.
Preferably, when the lid be fixedly connected with and gatherer insert after in the first cavity, gatherer is positioned at the first cavity and seals the first cavity; Lid is between the first cavity and the second cavity.
Preferably, the first cavity forces the through hole on the movable element disengaging lid of gatherer.
Preferably, when lid is moved relative to gatherer, the seal chamber on the gatherer that lid and gatherer are formed is compressed, in lid top projection contacts and poke the diaphragm seal collecting masthead end, seal chamber is connected with the cavity of collection bar.
Preferably, comprise buffer solution in sealed cavity, when sealing cavity is connected with the cavity of sample collection bar, buffer solution is flow on absorber element by the cavity be communicated with.Buffer solution flow on absorber element, mixes with the sample be positioned on absorber element, completes the pre-service of sample.
Preferably, lid forces first of the rib of the first cavity the protruding through hole departing from the second cavity.
Preferably, the rib of the first cavity comprises the second projection, lid oppresses the second projection makes rib bounce back; The protruding through hole departed from the second cavity of on it first after rib retraction.Like this, the first cavity departs from the second cavity and is connected, and can mutually move or rotate therebetween.
Preferably, when applicator is rotated together with lid in the first chamber and the second cavity, absorber element is compressed in the first cavity, and liquid flows in the first cavity and the second cavity; First cavity moves to reach the primary importance of the second cavity along with lid together with gatherer, and the first cavity seals the second cavity and forms seal chamber.
Preferably, when the first cavity rotates the second place of arrival second cavity together with lid, seal chamber is compressed, and the liquid quantitative in seal chamber enters test chamber.
Preferably, cover outer surface and the second cavity inner surface have the screw thread of occlusion mutually.
On the other hand, the present invention also provides a kind of method of collecting sample, comprises and provides a kind of device collecting sample, and this device comprises the first cavity and the second cavity, and the first cavity is positioned at the second cavity, and the two is detachable connection and liquid communication; Described first cavity can seal and compress the second cavity and the liquid quantitative in the second cavity is discharged.
Preferably, the first cavity can rotate mutually with the second cavity; Make the first cavity turn to the primary importance of the second cavity, the second cavity is sealed by the first cavity.
Preferably, make the first cavity turn to the second place of the second cavity, the second cavity of sealing is compressed, and the liquid in it is quantitatively discharged.
Preferably, this device also comprises applicator and the lid of movable connection; Applicator comprises the collection bar of hollow, and collect masthead end and sealed by diaphragm seal, end is connected with absorber element and is communicated with; Lid forms with collection masthead end the annular seal space be positioned on gatherer.
Preferably, the applicator that is fixedly connected with and lid is made to be inserted in the first cavity and the second cavity; Rotating cover, the movable element in the first cavity compressing applicator forces applicator to depart from lid and is fixedly connected with.
Preferably, then rotating cover, lid and applicator are rotated mutually, and the seal chamber on gatherer is compressed, in lid top projection contacts and poke the diaphragm seal collecting bar masthead end, seal chamber is connected with the cavity of collection bar; The damping fluid being positioned at seal chamber is flow on absorber element by the cavity be communicated with.
In superincumbent process, while the movement between lid and gatherer, the bottom to the first cavity and the second cavity is moved, and gatherer is constant relative to the first cavity position, namely can not be moved.
Preferably, then rotating cover, the lid rib of oppressing on the first cavity forces the first cavity of detachable connection to depart from the second cavity.
Preferably, then rotating cover, lid rotates together with applicator in the first cavity and the second cavity, and absorber element is compressed in the first cavity, and liquid flows in the first cavity and the second cavity; First cavity moves to reach the primary importance of the second cavity along with lid together with gatherer, and the second cavity sealing is formed seal chamber by the first cavity.
Preferably, then rotating cover, make the first cavity move to the second place in the second cavity, seal chamber is compressed, and the liquid quantitative in seal chamber enters and is attached thereto logical test chamber.
beneficial effect
By gathering-device of the present invention, buffer solution can be mixed fully with sample, particularly need pretreated detection for sample, completing smoothly of detection can be ensured.
Accompanying drawing explanation
Fig. 1 is the exploded perspective view of a device of the present invention;
Fig. 2 is parts---the schematic diagram of lid of apparatus of the present invention;
Fig. 3 is another parts of apparatus of the present invention---the schematic diagram of gatherer;
Fig. 4 is the schematic diagram that the parts of Fig. 2 and Fig. 3 are fixed together;
Fig. 5 is another parts of apparatus of the present invention---the schematic diagram of the first cavity;
Fig. 6 is another parts of apparatus of the present invention---the schematic diagram of the second cavity;
Fig. 7 is the schematic diagram of the collection chamber after the component combination of Fig. 5 and Fig. 6;
Fig. 8-Figure 21 is the schematic diagram of the section in A-A and the B-B direction of the operating process of apparatus of the present invention, and wherein A-A direction and B-B direction are orthogonal both direction;
Fig. 8 is the A-A diagrammatic cross-section that cover cap of the present invention is incorporated on the first cavity and the second cavity;
Fig. 9 is the B-B diagrammatic cross-section that cover cap of the present invention is incorporated on the first cavity and the second cavity;
Figure 10 is the A-A diagrammatic cross-section that lid of the present invention turns to a position (the first cavity oppresses movable element makes gatherer depart from lid) of the first cavity and the second cavity;
Figure 11 is the B-B diagrammatic cross-section that lid of the present invention turns to a position (the first cavity oppresses movable element makes gatherer depart from lid) of the first cavity and the second cavity;
Figure 12 is the A-A diagrammatic cross-section that lid of the present invention turns to another position (lid projection is poked and collected masthead portion) of the first cavity and the second cavity;
Figure 13 is the B-B diagrammatic cross-section that lid of the present invention turns to another position (lid projection is poked and collected masthead portion) of the first cavity and the second cavity;
Figure 14 is the A-A diagrammatic cross-section that lid of the present invention turns to another position (lid oppresses the first cavity rib forces the first cavity to depart from the second cavity) of the first cavity and the second cavity;
Figure 15 is the B-B diagrammatic cross-section that lid of the present invention turns to another position (lid oppresses the first cavity rib forces the first cavity to depart from the second cavity) of the first cavity and the second cavity;
Figure 16 is the A-A diagrammatic cross-section that the present invention first cavity is positioned at the primary importance (absorber element is compressed, and the first cavity seals the second cavity) of the second cavity;
Figure 17 is the B-B diagrammatic cross-section that the present invention first cavity is positioned at the primary importance (absorber element is compressed, and the first cavity seals the second cavity) of the second cavity;
Figure 18 is the A-A diagrammatic cross-section that the second place (annular seal space is compressed) that the present invention first cavity is positioned at the second cavity is put;
Figure 19 is the B-B diagrammatic cross-section that the present invention first cavity is positioned at the second place (annular seal space is compressed) of the second cavity;
Figure 20 is the inverted A-A diagrammatic cross-sections of apparatus of the present invention;
Figure 21 is the inverted B-B diagrammatic cross-sections of apparatus of the present invention;
Description of reference numerals:
Gathering-device 800; Lid 100; Lid bottom 109; Lid and gatherer connecting hole 101; Cap aperture 103; Perforate plug 102; External thread 105 on lid; Lid top 104; Lid bottom 110; The projection 111 that top and bottom join; Liquid storage cylinder 107 in lid; Top projection 106 in lid; The annular seal space 108 that lid and gatherer are formed; The opening part 109 of lid; Applicator 200; Gatherer end sealing film 201; The O-ring seal 202 that gatherer coordinates with lid; Gatherer internal cavity 210; Hold the groove 203 of lid internal projection; Collect bar (hollow) 205; The movable element (spring) 204 be connected with collection bar; The platform 2041 of spring; Hold the circular discs 209 of packing ring 202; Absorber element 207; The packing ring 208 that gatherer coordinates with the first cavity; Hold the circular discs 206 of packing ring 208; First cavity 300; Second cavity 400; First cavity accent 305; First cavity upper cavity 302; Cavity 303 in first cavity; First cavity lower chamber 306; Rib 310 on first cavity; Rib second projection 311; Rib first projection 312; The packing washer 301 that first cavity coordinates with the second cavity; Hold the groove 304 of packing washer 301; The hole 307 that first cavity is communicated with the second cavity; Second cavity internal thread 402; Base 401; Receive the hole 405 of rib projection; Second cavity upper cavity 403; Second cavity lower chamber 404; Little cavity 406 in second cavity; The accent 4061 of little cavity; The hole 408 that second cavity is communicated with test chamber; Test chamber 500, check-out console upper cover 502; Check-out console lower cover 501; Detecting element 600.
Embodiment
applicator 200
Usually, applicator 200 comprises absorber element 207 and collects bar 205, and absorber element 207 is positioned at the one end of collecting bar 205, as shown in Figure 3.Other sponge of medical grade that absorber element 207 is commonly used by this area usually or plastic foam material are made.But many other materials also can be made into absorber element, such as cotton or paper, or other any materials with water absorbing properties.Be affectedly bashful portion's normally rigidity, be conducive to the operation to absorber element.In certain embodiments, collect that bar is also double is affectedly bashful portion, the material that the portion of being affectedly bashful can be commonly used by this area is made, such as plastics, timber, metal or cardboard.In a preferred embodiment of the present invention, in order to enable the sample on absorber element pretreated, also comprise annular seal space on the collector, sealing chamber is for laying the buffer solution of process sample.Preferably, sealing cavity can liquid communication with absorber element in " specific situation "." specific situation " refers to when needs sample mixes with buffer solution.Preferably, seal chamber is connected with absorber element by " passage ".In concrete mode, this passage is the collection bar of hollow, and seal chamber is arranged in collection bar one end of control, and absorber element is positioned at hollow and collects the bar other end.When sample needs pretreated, seal chamber is communicated with absorber element by the collection bar of hollow, and buffering liquid flow on absorber element.
Preferably, collection bar 205 other end of applicator 200 is connected with lid 100, and as shown in Figure 4, this lid can have the function in the portion of being affectedly bashful concurrently.Further, annular seal space 108 is engaged in by what collect bar 205 and lid 100 the cavity formed in lid.The collection bar of hollow is communicated with the cavity 108 of lid; Further, the cavity of this collection bar is connected with absorber element 207.More specifically in embodiment, the top of collecting bar has diaphragm seal 201, and the cavity 108 collecting bar cavity and lid separates by sealing film 201.In some specific embodiments, when under " particular case ", when namely sample needs pre-service, can by making collection bar cavity 205 be connected with lid cavity 108 mode that diaphragm seal 201 is poked, as shown in figure 11.Some preferred embodiment in, in order to ensure being flexibly connected of gatherer and lid, gatherer also having movable element, is coordinated with lid by movable element, carry out the fixing of the two or be separated.This movable element 204 can be subjected to displacement within the specific limits.Usually, movable element has elasticity, and its one end is connected to collects on bar, and the other end can produce mobile when receiving pressure.In a specific embodiment, movable element is spring 204, and this spring 204 is for being connected with collection chamber 300.In a specific embodiment, spring 204 is two, the middle part being positioned at collection bar 205 of these two spring 204 symmetries.The shape of spring 204 is hook-type, the change of position can be there is when spring 204 runs into pressure, that is, when applicator 200 is positioned at collecting chamber 200, when spring 204 is subject to the pressure from collecting chamber 300, spring 204 can automatic rebounding, thus makes gatherer 200 can the movement of generation position freely in collecting chamber 300.In another specific embodiment, gatherer 200 is fixedly connected with by spring 204 with lid 100.When the stressed rear generation the unknown skew of spring 204, spring 204 leaves lid 100, and lid 100 departs from gatherer 200 relation be fixedly connected with.
lid 100
In the present invention, also comprise a lid 100, this lid for sealing collection chamber 300, as shown in Figure 2.In a specific embodiment, lid 100 is connected with gatherer 200 and is communicated with.More specifically in embodiment, lid 100 and gatherer 200 are for being flexibly connected, and in an operating process, lid 100 and gatherer 200 are for being fixedly connected with; And in another process, lid 100 and gatherer 200 be not for be fixedly connected with.Preferably, lid has the through hole coordinating with the movable element on gatherer and make the two fix or be separated, in specific embodiment, through hole is 2, identical with the movable element quantity on gatherer.After gatherer inserts lid, the cylinder on gatherer top coordinates to be formed with lid madial wall and seals, also the cavity 204 of sealing is namely formed, gatherer continues in lid deeply mobile, the end thereof contacts collecting the opening of the movable element on bar is to the through hole on lid and enter in through hole, is formed fixing.Now, gatherer and lid position are fixed, and the volume collecting the seal chamber above bar is also fixed.
Preferably, in order to ensure that seal chamber is communicated with when needs with absorber element, in the seal chamber on lid, also namely lid portion inside tip designs has projection, and one end of this projection is sharp-pointed, can poke and comprise aluminium foil, paper, the materials such as plastic sheeting.When sample needs pre-service, then make this projection contacts to the diaphragm seal collecting masthead end, make it poke diaphragm seal, thus make annular seal space and collect bar cavity connects.In a concrete embodiment, by the mutual rotation between lid and gatherer, the cavity of sealing is compressed, smaller volume, the distance that lid top distance collects masthead end reduces, the diaphragm seal of masthead end is collected in the projection contacts on lid top compressing, pokes the connection that diaphragm seal realizes between cavity.
In an embodiment, on lid 100 lateral wall, there is the screw thread 105 coordinated with collection chamber.In other embodiments, the inner tip of lid also comprises a liquid storage cylinder 107, and this liquid storage cylinder 107 is for storing liquid sample unnecessary after testing.More specifically in mode, lid 100 also has an opening 103 in liquid storage cylinder 107 corresponding position, the liquid in liquid storage cylinder 107 can be taken out again detect confirmation by this opening 103.
collection chamber (the first cavity, the second cavity)
Usually, collection chamber for accepting liquid sample, and is communicated with test chamber 500, and sample is sent on detecting element 600 and completes detection the most at last.In concrete embodiment, collection chamber is enclosed by sidewall and bottom and forms, and have an opening, opening is for accepting sample.In the present invention, in order to realize the function of quantitative sample injection, collection chamber is split-type structural, is specifically made up of two cavitys, the first cavity 300 and the second cavity 400.
As shown in Figure 5 and Figure 6, wherein, it is inner that the first cavity 300 is positioned at the second cavity 400, and, be connected between two cavitys, as shown in Figure 7.Concrete, at the first cavity bottom, there is through hole, by this through hole 307, first cavity is connected with the second cavity.Preferably, this through hole 307 is sealed when the first cavity seals and compresses the second cavity.As shown in Figure 5, the first cavity bottom has a little cavity 306, and this little cavity 306 opening is contrary with the direction of the first cavity, namely opening down, with above in cavity cut off by bottom, be communicated with by means of only through hole; In second cavity, obviously reduce at the bottom space of cavity, form another little cavity 406; When the first cavity seals the second cavity, little cavity 306 is positioned at the little cavity 406 of the second cavity bottom, and the lower chamber 406 of top seal second cavity of the little cavity 306 of the first cavity, forms the cavity of sealing.When the first cavity compresses the second cavity, the little cavity 306 of the first cavity moves to bottom in the inner chamber body 406 of the second cavity, the top compression seal chamber 406 of little cavity 306.More excellent, when there being liquid in seal chamber 406, liquid is compressed.
In one embodiment, the first cavity 300 is detachable connections with the second cavity 400, is also namely flexibly connected, under a state, two cavitys are fixed together, under another state, two cavitys depart from mutually, and therebetween can movement mutually.In another concrete embodiment, the first cavity 300 is connected with first projection 312 of the second cavity 400 by the rib of the first cavity and fixes.Preferably, this rib has elasticity, facilitate rib and on projection retraction.In some specific embodiments, this rib is positioned on the first cavity, be a part for the first cavity, but only one end is connected with the first cavity, remainder hollow out.This structure effectively can increase the elasticity of rib, be rib when running into pressure, position changes.
In other embodiments, when first cavity is positioned at position (primary importance) of the second cavity, first cavity and the second chamber inner sidewall are formed and seal, by the second cavity sealing, more specifically, an airtight cavity 406 is formed between first cavity and the second cavity, this airtight cavity is connected by through hole 307 with the first cavity, after this through hole 307 is sealed, airtight cavity 406 and test chamber 500 form the space sealed, because the air in seal cavity is a certain amount of, when compressing the air in this seal cavity, what can make the liquid quantitative being positioned at airtight cavity enters test chamber, thus realize the function of quantitative sample injection.
Below the technical term that the structure that the present invention relates to or these use is described further.In the following detailed description, the subsidiary reference word of legend is a part here, and it is to illustrate that the present invention can the mode of actable specific concrete scheme illustrate.We do not get rid of the present invention can also carry out other concrete scheme and when without prejudice to changing structure of the present invention when usable range of the present invention.
As shown in Figure 1, a concrete gathering-device of the present invention is 800, and this device comprises four parts: lid 100, gatherer 200, the first cavity 300 and the second cavity 400.By the cooperation of these four parts, realize the sample of this device and mixing of damping fluid, the collection of sample mixed liquor and the function such as the quantitative sample injection of sample and the detection of sample.
As shown in Figure 2, lid 100 is divided into upper and lower two parts, i.e. lid top 104; Lid bottom 110; Wherein, top 104 is less than bottom 110, and therefore, top 104 and junction, bottom 110 have protruding ring-shaped platform 111.Have a liquid storage cylinder 107 in the inner side on lid top, this cavity 107 is in communication with the outside by a perforate 103, and this liquid storage cylinder 107 detects rear remaining sample for storing, and reaffirms that detection uses to facilitate.Perforate 103 comprises a perforate plug 102, by this perforate plug 102, liquid storage cylinder 107 and lid 100 is sealed.In addition, the middle position of lid bottom 110 also has two symmetrical holes 101, and this hole 101 is for being connected with gatherer 200 and making the two fix.In some specific embodiments, on the top of lid 100 inside, also there is a projection 106, as shown in Figure 9.Meanwhile, in order to realize coordinating of lid 100 and collecting chamber, and lid can seal collecting chamber, also has screw thread 105 at the lower outside of lid 100.
As shown in Figure 3, applicator 200 is made up of the absorber element 207 collecting bar 205 and be connected with collection bar one end, and, collecting the other end of bar 205, there is a rounded face 209, sealing for being formed with lid 100.The sidewall contacted with lid in rounded face 209 has groove and is positioned at the O-ring seal 202 of groove.The diameter collecting the rounded face 209 of bar is identical with the internal diameter on lid top 104, thus when gatherer 200 is connected with lid 100, the rounded face 209 of collecting bar closely cooperates with the upper interior portion of lid, and to be formed with lid upper inner wall by the packing ring 202 that is positioned in rounded face and seal, thus, form a cavity sealed 108 on collection bar 205 top and lid portion inside.In a specific embodiment, the collection bar 205 of gatherer is the structure of hollow, by the part of this hollow, the top of gatherer is connected with bottoms liquid, is namely connected with the absorber element 207 of bottom.On the top of gatherer 205, there is a diaphragm seal 201 hollow space of gatherer 200 is sealed.Diaphragm seal material can use plastics, has the film or paper etc. of sealing function, and it can meet two functions: hydraulic seal and can being poked by sticker.In an embodiment, also have the groove 203 holding lid internal projection on the hollow space top of collecting bar, when lid and gatherer are positioned under a kind of connection status, the projection 106 on lid pokes the diaphragm seal 201 on top, and is positioned at this groove 203.In some concrete embodiments, gatherer 200 also has two symmetrical springs 204, this spring 204 has the function of retraction when running into pressure.This spring 204 is barb shape, has a little platform at end.On gatherer 200, can be sealed in collecting chamber to make absorber element 207, above absorber element 207, also comprise the disk 206 identical with collecting chamber internal diameter, be designed with groove at disk side, there is in groove the O-ring seal 208 that can seal collection chamber.
As shown in Figure 4, when lid and gatherer in conjunction with time, the rounded face on gatherer top enters in lid by the opening 109 of lid, rounded face is by the ring-shaped platform of arrival top and the bottom, lid bottom, start the top 104 of sealing cover body, continue to promote gatherer 200, until the platform 2041 of spring on gatherer is positioned on the through hole 101 in the middle part of lid, the two is now in stationary state, and when gatherer 200 is positioned at lid 100, therebetween form the cavity 108 of a sealing, this cavity is the cavity 108 for laying buffer solution.
As shown in Fig. 5, the first cavity 300 comprises upper cavity 302, middle cavity 303 and lower chamber 306 3 part, and three cavitys from top to bottom diameter reduce successively.Separated by dividing plate between middle cavity 303 and lower chamber 306, dividing plate has through hole 307 to ensure the connection of three cavitys.Wherein, upper cavity 302 have two symmetrical ribs 310.This rib 310 is connected with cavity 300 for one end, and remainder is not connected with cavity 300, and when rib 310 runs into pressure, the position of rib 310 can offset.Rib 310 has two projections, is the second protruding 311 and first projection 312 respectively.Wherein, the first projection 312 is for the connection of this cavity and the second cavity 400.In an embodiment, have groove 304 in middle cavity 303 and the junction of lower chamber 306 and be positioned at the packing washer 301 of groove, when the first cavity is positioned at the second inside cavity, packing ring 301 seals the madial wall of the second cavity.
In figure 6, the second cavity 400 comprises upper cavity 403 and lower chamber 404, and the top, inner side of upper cavity has screw thread 402, and this screw thread 402 is corresponding with the screw thread 105 outside lid.In the outside of the second cavity, also have pattern detection chamber 500, this test chamber 500 is connected by through hole 408 with the second cavity 400, ensures that the liquid being positioned at the second cavity 400 can flow into test chamber 500 by through hole 408.In the bottom of the second cavity, there is base 401.Upper cavity 403 also has the hole 405 of the rib 310 of connection first cavity, when the first cavity 300 is positioned at the second cavity 400, first projection 312 of the rib on the first cavity is positioned on the hole 405 of the second cavity, now, first cavity 300 is fixed in the second cavity 400, as shown in Figure 7.As shown in Figure 8, also have a little cavity 406 in the second cavity lower chamber 404 inner bottom, the internal diameter of this cavity is identical with the external diameter of the lower chamber 306 of the first cavity, for holding lower chamber 306 and forming sidewall seal with the O-ring seal 301 above lower chamber.
Equally as shown in Figure 6, detecting element 600 can be placed in test chamber 500, for detecting the sample flow in test chamber.In a specific embodiment, place a check-out console in this test chamber, detecting element 600 is placed on wherein by upper plate 501 and covering of lower plate 502 by check-out console.
Specific operation process below with regard to this gathering-device 800 is described in detail.Fig. 8-Figure 21 describes the concrete state of gathering-device after the operation steps of this sample collection device and each operation steps by the mode of diagrammatic cross-section.When original state, lid 100 is connected with gatherer 200 and is mutually fixed by spring 204, now, in the cavity 108 of sealing, has buffer solution; First cavity 300 is positioned at the second cavity 400 and is mutually permanently connected by rib 310, and now, in the upper cavity 302 of the first cavity and part, cavity 303 is positioned at the upper cavity 403 of the second cavity, and remainder is positioned at the lower chamber 404 of the second cavity; After the absorber element 207 in applicator gathers sample, such as saliva sample, lid 100 is allowed to cover on collecting chamber, now, applicator 200 is positioned at the first cavity 300, and the opening 109 of lid is positioned at the centre of the first cavity 300 and the second cavity 400, as shown in Figure 8, meanwhile, the first cavity 300 is also between lid 100 and applicator 200; Now, the buffer solution of buffering is laid in the sealed cavity 108 be connected to form by lid 100 and gatherer 200; Further, as shown in Figure 9, the projection 106 being positioned at lid top is positioned at annular seal space 108, and the diaphragm seal 201 on the top of this projection 106 distance gatherer has certain distance.
Then, rotate lid 100, the screw thread 105 of lid portion outside is engaged mutually with the screw thread 402 of the second inside cavity, lid 100 is moved downwards along the first cavity 300 and the second cavity 400, arrive two positions, as shown in Figure 10, now, because applicator 200 and lid 100 are fixed together by spring 204, applicator 200 moves along with the movement of lid 100, thus the spring 204 in applicator starts the accent 305 touching the first cavity, because spring 104 has elasticity, oppressed by the accent 305 of the first cavity and inwardly resilience, make the perforate 101 that the platform 2041 on spring starts away from lid, thus applicator 200 is departed from lid 100 be fixedly connected with, as shown in Figure 10.And as shown in Figure 11, because gatherer 200 and lid 100 are fixedly connected, the change of position does not occur between lid 100 and gatherer 200, thus the projection 106 of lid does not also change apart from the distance of diaphragm seal 201.
Rotate lid 100 again, lid 100 continues to move down along the first cavity 300 and the second cavity 400 in the mode of threaded engagement, makes lid 100 arrive the second protruding 311 places of the rib in the first cavity.As shown in figure 12, in the process of this movement, because applicator 200 and lid 100 depart from fixing connection, then continue in the process moved down at lid 100, applicator 200 is no longer along with lid 100 moves, namely applicator 200 is relative to the invariant position of the first cavity 300 and the second cavity 400, and namely the accent of the first collecting chamber contacts with the center of the spring of gatherer.And the position between applicator 200 and lid 100 changes; Along with moving down of lid 100, the annular seal space 108 between lid 100 and applicator 200 reduces, as shown in figure 12, like this, the lid projection 106 being positioned at annular seal space moves closer to the diaphragm seal 203 on applicator top, finally arrives diaphragm seal 203 and punctures diaphragm seal, as shown in figure 13.Annular seal space 108 is connected with the cavity 210 of applicator, buffer solution in annular seal space 108 flow in the cavity 210 of applicator, on absorber element 207 in final arrival applicator, mix fully with the sample that absorber element 207 is collected, pre-service is carried out to the sample on absorber element.On the top of applicator cavity 210, there is the groove 203 of a large funnel type, for holding the projection 106 of lid, meanwhile, also facilitating the liquid in annular seal space 108 to flow in the cavity 210 of applicator.
Again rotate lid, lid 100 continues to move down along the first cavity 300 and the second cavity 400.As shown in figure 14, now, in the process that lid moves down between the first cavity 300 and the second cavity 400, because the second projection 311 on rib touches opening 109 place of lid 100, continue in the process moved down at lid 100, lid opening 109 is urged in the second projection 311, makes the second protruding 311 resiliences, and related whole rib 310 inwardly compresses.The first projection 312 be positioned on rib is also forced to the first cavity 300 and is bounced back, thus the through hole 405 of first protruding 312 disengaging the second cavitys, as shown in figure 14.Once first protruding 312 departs from through hole 405, the first cavity 300 is no longer fixedly connected with the second cavity 400, position can occur therebetween and move.In addition, as shown in figure 15, lid moves to the top of applicator, namely annular seal space 108 by compression without, also, when lid moves down again, gatherer is inconjunction with and moves together.
Again rotate lid 100, lid continues to move down along the first cavity 300 and the second cavity 400, and now, because gatherer 200 has arrived the top of lid 100, therefore, the two moves together.In the process of movement, the accent 305 of the first cavity arrives the top of the spring 204 of gatherer, projection 111 place that the top and the bottom simultaneously also arriving lid have a common boundary, and is stopped by lid 100, no longer moves, as shown in figure 16.And, absorber element 207 now on gatherer is because of the Distance Shortened between the first cavity and gatherer, the space of absorber element 207 in the first cavity in cavity 303 is made to reduce and be compressed, mixed liquor on element 207 flow in the first cavity in cavity 303, as shown in Figure 16 and Figure 17.Meanwhile, because the first projection 312 has departed from the hole 405 of the second cavity before, first cavity 300 departs from the second cavity 400 and is fixedly connected with, after lid rotates, projection 111 place that first first cavity 300 arrives lid is stopped and is fixed, when lid 100 continues to rotate, the first cavity 300 is driven to move down in the second cavity 400, first cavity 300 is moved down in the second cavity 200, the first cavity is finally made to arrive the primary importance of the second cavity, now, packing washer 301 on the lower chamber of the first cavity arrives accent 4061 place of the inner chamber body 406 in the second collection chamber, inner chamber body 406 is sealed, as shown in figure 16, now, the lower chamber 306 of the first cavity 300 and inner chamber 406 body of the second cavity form an airtight cavity, this airtight cavity is communicated with middle cavity 303 by means of only through hole 307, and be connected with test chamber 500 by through hole 408, as shown in figure 17.
Again rotate lid, now, applicator 200 and the first cavity 300 continue mobile along with lid 100 together in the second cavity 400, make the first cavity 300 arrive the second place of the second cavity.As shown in Figures 18 and 19, in the process of lid movement, absorber element is compressed again, mixed liquors all on it is discharged in middle cavity 303, and flow in airtight cavity by through hole 307, along with the compression of absorber element, the drain of final absorber element also blocks through hole 307, and, cavity 303 sidewall also seals by the packing ring 208 be arranged on absorber element, making airtight cavity and test chamber 500 form the space of sealing, is all fixing amount by the air that seals and liquid in the space of sealing.Continue in the process of movement at lid 100, first body 300 continues to go deep into the second cavity 400, the lower chamber 306 of the first cavity is made to enter in inner chamber body 406 completely, and, the space 406 of sealing is further compressed, and the air pressure in space is increased, thus makes the certain quantity of fluid in inner chamber body 406 enter test chamber 500 by through hole 408, and arrive detecting element place, finally complete the detection of sample.Wherein, the amount of liquid entering test chamber is rotated by lid thus the size in the space of compression seal decides.
After detection completes, as shown in Figure 20 and Figure 21, this gathering-device 800 is inverted, makes sample unnecessary in test chamber 500 be back to collecting chamber, now, convolution lid 100, makes airtight space pressure reduce, and most end form negative pressure, the backflow of more convenient liquid, the liquid of backflow is flow on absorber element 207 by through hole 307, then flow in collection bar cavity 201, in final arrival liquid storage cylinder 106 by absorber element.When needs sample, open stopple 102, from through hole 103, sample is taken out.
Claims (11)
1. a sample collection device, comprises applicator, wherein, gatherer has seal chamber.
2. device according to claim 1, is characterized in that, seal chamber can be connected by channel liquid with the absorber element on gatherer.
3. device according to claim 2, is characterized in that, this device also comprises a lid, and lid and gatherer form the seal chamber on gatherer.
4. device according to claim 3, is characterized in that, lid and gatherer are detachable connection.
5. device according to claim 4, is characterized in that, lid and gatherer to be coordinated with the through hole of lid by the movable element on gatherer and achieve a fixed connection and be separated.
6. device according to claim 5, is characterized in that, when being positioned at the hole on lid when movable element, lid is fixedly connected with gatherer; When movable element departs from the hole on lid, can rotate between lid and gatherer.
7. device according to claim 6, is characterized in that, by the movement between lid and gatherer, makes the volume of seal chamber reduce or increase.
8. device according to claim 6, is characterized in that, by the movement between lid and gatherer, seal chamber is connected by passage with the absorber element of gatherer.
9. according to the device one of claim 1-8 Suo Shu, it is characterized in that, described passage comprises the collection bar of hollow, and collect bar one end and connect absorber element, the other end is sealed and connects seal chamber.
10. device according to claim 9, is characterized in that, pokes the diaphragm seal collecting masthead end the collection bar of seal chamber and hollow and absorber element are communicated with by the projection in seal chamber.
11. device according to claim 1, is characterized in that, in seal chamber, there is buffer solution.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310651785.4A CN104697811A (en) | 2013-12-05 | 2013-12-05 | Sample collection apparatus and method thereof |
| EP14868416.0A EP3077788A4 (en) | 2013-12-05 | 2014-11-30 | Device and method |
| CN201480065961.9A CN105814430A (en) | 2013-12-05 | 2014-11-30 | Device and method |
| PCT/CN2014/092625 WO2015081818A1 (en) | 2013-12-05 | 2014-11-30 | Device and method |
| US15/101,355 US20160302773A1 (en) | 2013-12-05 | 2014-11-30 | Device and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310651785.4A CN104697811A (en) | 2013-12-05 | 2013-12-05 | Sample collection apparatus and method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104697811A true CN104697811A (en) | 2015-06-10 |
Family
ID=53345168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310651785.4A Pending CN104697811A (en) | 2013-12-05 | 2013-12-05 | Sample collection apparatus and method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104697811A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108802020A (en) * | 2017-05-05 | 2018-11-13 | 马克西拉博有限公司 | Toxicity detection kit with anti-tamper saliva acquisition system and system of giving counterevidence |
| CN109342673A (en) * | 2018-12-14 | 2019-02-15 | 深圳市心月生物科技有限公司 | A kind of cream jug |
| CN110161267A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | The detection device of analyte in a kind of detection sample |
| CN111398609A (en) * | 2019-01-02 | 2020-07-10 | 深圳迈瑞生物医疗电子股份有限公司 | Sample rack scheduling method and sample introduction processing system |
| US10830672B2 (en) | 2018-02-13 | 2020-11-10 | Hangzhou Biotest Biotech Co., Ltd. | Apparatus for collecting liquid sample |
| EP3752841A4 (en) * | 2018-02-13 | 2021-11-03 | Hangzhou Biotest Biotech Co., Ltd. | An apparatus for collecting liquid sample |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792699A (en) * | 1972-05-30 | 1974-02-19 | Medex Inc | Disposable swab unit |
| US3918435A (en) * | 1974-01-24 | 1975-11-11 | Miles Lab | Transport swab tube |
| US4407283A (en) * | 1981-10-19 | 1983-10-04 | Dale C. Grier | Self-injecting syringe |
| ES2003926A6 (en) * | 1986-11-14 | 1988-12-01 | Copan Srl | Tampon for taking specimens of substances to be analysed |
| US5238649A (en) * | 1988-02-09 | 1993-08-24 | Nason Frederic L | Specimen test unit |
| KR100453049B1 (en) * | 2002-05-13 | 2004-10-15 | 삼성전자주식회사 | Method of transmitting and receiving fax data |
| CN101326443A (en) * | 2005-11-30 | 2008-12-17 | 英维利斯医疗诊断公司 | Apparatus and method for detecting analysis article in fluid sample |
| US20090024060A1 (en) * | 2007-04-16 | 2009-01-22 | Darrigrand William A | Sample collector |
| WO2009012307A2 (en) * | 2007-07-16 | 2009-01-22 | Forensic Id, Llc | Specimen gathering device and method of use |
| CN101464457A (en) * | 2008-07-23 | 2009-06-24 | 吕欣龙 | Detecting instrument for liquid sample |
-
2013
- 2013-12-05 CN CN201310651785.4A patent/CN104697811A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792699A (en) * | 1972-05-30 | 1974-02-19 | Medex Inc | Disposable swab unit |
| US3918435A (en) * | 1974-01-24 | 1975-11-11 | Miles Lab | Transport swab tube |
| US4407283A (en) * | 1981-10-19 | 1983-10-04 | Dale C. Grier | Self-injecting syringe |
| ES2003926A6 (en) * | 1986-11-14 | 1988-12-01 | Copan Srl | Tampon for taking specimens of substances to be analysed |
| US5238649A (en) * | 1988-02-09 | 1993-08-24 | Nason Frederic L | Specimen test unit |
| KR100453049B1 (en) * | 2002-05-13 | 2004-10-15 | 삼성전자주식회사 | Method of transmitting and receiving fax data |
| CN101326443A (en) * | 2005-11-30 | 2008-12-17 | 英维利斯医疗诊断公司 | Apparatus and method for detecting analysis article in fluid sample |
| US20090024060A1 (en) * | 2007-04-16 | 2009-01-22 | Darrigrand William A | Sample collector |
| WO2009012307A2 (en) * | 2007-07-16 | 2009-01-22 | Forensic Id, Llc | Specimen gathering device and method of use |
| CN101464457A (en) * | 2008-07-23 | 2009-06-24 | 吕欣龙 | Detecting instrument for liquid sample |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108802020A (en) * | 2017-05-05 | 2018-11-13 | 马克西拉博有限公司 | Toxicity detection kit with anti-tamper saliva acquisition system and system of giving counterevidence |
| CN110161267A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | The detection device of analyte in a kind of detection sample |
| CN110161266A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | A method of collecting liquid sample |
| CN110161265A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | A kind of device for collecting liquid sample |
| CN110161264A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | A kind of device for collecting liquid sample |
| CN110161268A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | A kind of device for collecting liquid sample |
| US10830672B2 (en) | 2018-02-13 | 2020-11-10 | Hangzhou Biotest Biotech Co., Ltd. | Apparatus for collecting liquid sample |
| EP3752841A4 (en) * | 2018-02-13 | 2021-11-03 | Hangzhou Biotest Biotech Co., Ltd. | An apparatus for collecting liquid sample |
| CN109342673A (en) * | 2018-12-14 | 2019-02-15 | 深圳市心月生物科技有限公司 | A kind of cream jug |
| CN111398609A (en) * | 2019-01-02 | 2020-07-10 | 深圳迈瑞生物医疗电子股份有限公司 | Sample rack scheduling method and sample introduction processing system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203869898U (en) | Sample collecting device | |
| CN104697811A (en) | Sample collection apparatus and method thereof | |
| CN105784443B (en) | A kind of sample testing apparatus and sample collection detection device and method | |
| CN103217313B (en) | A kind of feces collection pick-up unit and the method based on this device detection ight soil | |
| CN104956197B (en) | A kind of device collected and detect analyte in liquid fluid sample | |
| CN104634611B (en) | A method of the device of quantitative shunting is carried out to liquid sample and uses the device | |
| CN107238697B (en) | A method of it collects and detects sample | |
| CN106238108A (en) | Plastic containers, apparatus that leakproof is airtight and the method collecting liquid sample | |
| CN105829861A (en) | A device and method for using the device | |
| CN102379724A (en) | Device for collecting fluid samples | |
| CN114113595B (en) | Virus extraction and storage integrated detection tube and application method thereof | |
| CN217442869U (en) | Excrement sampling and detecting device | |
| US20160302773A1 (en) | Device and method | |
| CN202928839U (en) | Sample collection device | |
| CN201974302U (en) | Device for collecting, storing or detecting fluid samples | |
| CN104697816A (en) | Device and method | |
| US9352313B2 (en) | Device for collecting and testing analyte in a liquid sample | |
| CN208307494U (en) | A kind of quantitative liquid medicament taking bottle applied to laboratory test department | |
| CN204269419U (en) | A kind of sampler | |
| CN105814430A (en) | Device and method | |
| CN203587596U (en) | Detection device | |
| CN105748108B (en) | A kind of device | |
| CN213551959U (en) | Sample container and gynecological secretion detection device | |
| CN203710050U (en) | Neurological cerebrospinal fluid specimen sampling device | |
| CN212410604U (en) | Detection device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150610 |