CN107238697B - A method of it collects and detects sample - Google Patents
A method of it collects and detects sample Download PDFInfo
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- CN107238697B CN107238697B CN201710241346.4A CN201710241346A CN107238697B CN 107238697 B CN107238697 B CN 107238697B CN 201710241346 A CN201710241346 A CN 201710241346A CN 107238697 B CN107238697 B CN 107238697B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
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Abstract
The present invention relates to a kind of methods collected and detect sample, wherein including the device for collecting and detecting sample, which includes collecting chamber, the extrusion cylinder in collecting chamber, testing element and applicator；The testing element is connected with collecting chamber fluid；Wherein: collector being collected into sample, makes the hydraulically full sample of collector；It will be filled with being flowed into sample in collecting chamber in the extrusion cylinder in the collector insertion collecting chamber of liquid sample；Make in collecting chamber sample be flowed into testing element to be detected；Testing result on read test element.The device and collection detection method more Environmental Safety of applicator and sample collection and detection of the invention, it is easier to be received by subject, and use is simple laborsaving, and subject is facilitated to operate.
Description
Technical field
The present invention relates to a kind of methods collected and detect sample, in particular to for collecting and detecting the receipts of fluid sample
Storage and collection and detection device are come the method for collecting and detect analyte in liquid sample.
Background technique
Following background technique is used to help reader and understands the present invention, and is not construed as the prior art.
This technology in sample with the presence or absence of analyte is detected using immune association reaction principle to be used extensively
In every field.The analyte of various biological samples (saliva, blood, urine, serum, sweat etc.) can be detected with it
Matter monitors the health status (early pregnancy, tumour, infectious disease, drugs etc.) of disease and the mankind.The basic original of this detection technique
Reason is built upon the performance between immune molecule with specific bond, such as antibody and antigen, haptens/antibody, biotin with
Antibiotin etc..
In medical diagnostic field, detection liquid sample is not collected using detection device or detection cup, and judge liquid-like
Whether contain analyte in this, is a kind of commonplace method.Such detection device or detection cup generally require sample
Originally it is collected in sample container, related technical personnel include into a detection reagent item and a part of reagent strip is made to be immersed in sample
In, reagent strip is taken out after some time and reads testing result.
United States Patent (USP) US2004/0184954 and US2004/0237674 disclose some collection salivas and are detected
In saliva whether the device containing illicit drugs ingredient.In the two patents, both provides collection and detect the device of saliva
And method, will be on collector in absorption piece by applying external force after sample is sampled on collector in these devices
Sample is expressed in collecting chamber, is then detected again.
In these devices, collecting sample is usually that the absorber element of collector is placed into subject oral cavity on collector
It is acquired, existing collector is all made of glue and absorber element is adhesively fixed on collecting handle, because glue can be odorous
It generates, while also containing the unfavorable chemical component of some pairs of human bodies, usually have subject's discomfort, and due to subject's discomfort
The case where enough sample sizes cannot be acquired.In addition, these existing collection and detection devices generally use and place absorption piece
Enter in collecting chamber, applying pressure on handle makes absorber element be collected chamber and handle extruding compression to make sample from absorber element
Upper outflow, this requires to squeeze collector using biggish power, so that the sample on collector is transferred in collection device.
The operator makes troubles, especially women operator.
Summary of the invention
The present invention provides a kind of methods collected and detect sample, by a kind of applicator of new construction, and
Analyte in liquid sample is collected and is detected in the operation of the device of the sample collection and detection that are used cooperatively with the collector
Method.This method operation is more easily simple and laborsaving, facilitates operation.And the new applicator passes through absorber element
Absorber element is connected or fixed to bond absorption piece without the use of glue across the mode for collecting stick and collect stick, make to be examined
Person no longer touches the glue of bonding, and use is safer.And the new sample collection and detection being used cooperatively with collector
Device relatively before device operation more easily it is simple and laborsaving, facilitate operation.
In the present invention, a kind of method collected and detect sample is provided, wherein including the dress for collecting and detecting sample
It sets, which includes collecting chamber, the extrusion cylinder in collecting chamber, testing element and applicator；The testing element with
Collecting chamber fluid is connected；Wherein:
Collector is collected into sample, makes the hydraulically full sample of collector；
It will be filled with the extrusion cylinder in the collector insertion collecting chamber of liquid sample, be flowed into sample in collecting chamber；
Make in collecting chamber sample be flowed into testing element to be detected；
Testing result on read test element.
Preferably, the applicator includes collecting stick and absorber element, and the absorber element has hollow cavity；
The portion collection stick is housed in the hollow cavity of absorber element；Collect have on stick stop and positioning absorber element the
One lug；Collector further includes the gasket with through-hole, and through-hole, which passes through collection stick, makes gasket be connected to collection stick one end；The suction
Element is received to be located between gasket and the first lug；The tube port position of extrusion cylinder has platform；The internal diameter of extrusion cylinder is greater than or equal to
It collects the diameter of stick and is less than the diameter of gasket；Wherein:
When collector collects sample, make the hydraulically full sample of absorber element；
After collector is inserted into collecting chamber, it is located at the absorber element on collector right above extrusion cylinder nozzle；
Make collector continue the direction along insertion extrusion cylinder again to move, the intracorporal collection stick of the chamber hollow positioned at absorber element
Into in extrusion cylinder, the nozzle platform that the gasket of absorber element bottom is squeezed pressure cylinder stops, and absorber element is by nozzle platform and pad
Piece compresses after squeezing, and liquid is flow on nozzle platform and extrusion cylinder side wall after squeezing out in absorber element；
Preferably, the height of extrusion cylinder is greater than or equal to the length of absorber element；Wherein:
The absorber element of collector is all compressed, and liquid is all along nozzle platform and extrusion cylinder side wall stream in absorber element
Enter into collecting chamber.
In the present invention, during collecting sample, the collection stick part in absorber element enters extrusion cylinder, makes to squeeze
Position between pressure cylinder and collector is fixed, to keep absorber element also more fixed relative to extrusion cylinder platform；Meanwhile because inhaling
It receives element ring to collect on stick around between the first lug and gasket, absorber element is squeezed on the collector when applying pressure
When pressure compression, because absorbing on the collection stick between the first lug being fixed on nozzle platform and gasket of absorber element position
Because of external extruding positional shift will not occur for element, so that the extruding force applied not will disperse, be completely used for compressing
Absorber element.And under normal conditions, in existing collector, absorber element is located at one end of handle, during compression, by
There is elasticity in absorber element, the movement of position can occur when compressed, make the pressure dissipation of compression.Therefore, applying together
In the case where the power of sample, absorber element compression effectiveness of the invention is more preferable, and compression is more thorough, and sample discharge is more.So
The present invention cooperates the liquid sample squeezed in absorber element more laborsaving and efficient by extrusion cylinder with collector.
Preferably, collecting one end end end that stick is connected with absorber element has latch, and latch, which protrudes from, collects stick surface；
Collecting one end end that stick is connected with absorber element has groove；Wherein:
Collector continues to squeeze direction in card cylinder along insertion and moves, and collection stick end latch, which enters, is squeezed pressure cylinder in extrusion cylinder
Inner sidewall squeezes, and collecting stick end enters collection stick end in extrusion cylinder to groove variations, and then collects stick and enter extrusion cylinder
It is interior；
After absorber element is all compressed, one end end arrival extrusion cylinder bottom that stick is connected with absorber element is collected, is received
Collection stick is fixed in extrusion cylinder by latch.
Preferably, which further includes test chamber, and test chamber is connected with collecting chamber fluid；Testing element is located at test chamber
It is interior.
Preferably, which further includes Ka Gai, and Ka Gai lid, which closes, to be fixed at collecting chamber accent；Card, which covers, has opening, opens
Mouth position is corresponding with extrusion cylinder position；Card, which covers, has cyclic annular convex block, and collecting on stick has the second protrusion, and the second protrusion is located at the
Between one protrusion and the collection stick other end；Wherein:
It is located at the surface of extrusion cylinder nozzle after the collector insertion card cover gab；
It is described that when the second lug reaches at annular lug, absorber element is all compressed, collector be prevented from continuing into
Enter in collecting chamber.
On the other hand, a kind of applicator is also provided in the present invention, including collects stick and absorber element, wherein is described
Absorber element has hollow cavity；The portion collection stick is housed in the hollow cavity of absorber element.
Portion collection stick, which is housed in the hollow cavity of absorber element, makes collection stick be connected with absorber element；That is,
Absorber element is connected to the one end for collecting stick, specifically makes to collect stick one end and is absorbed member with portion collection the stick more than end
The hollow cavity of part is accommodated, meanwhile, absorber element, which is entirely located in, to be collected on stick.
In some preferred embodiments, in order to enable absorber element is not easy to slide on collecting stick, connect therebetween
It is closer, the hollow cavity of absorber element and the cooperation of collection stick zero clearance.That is the structure of the hollow cavity of absorber element and big
Small all identical as collection stick structure and size, hollow cavity inner surface and collection stick outer surface connects.
In some preferred embodiments, collecting has the first lug for stopping and positioning absorber element on stick.This first
Lug limits absorber element and is collecting the position on stick for preventing absorber element from further moving on collecting stick.One
In a little specific embodiments, position of first lug on collection stick is corresponding with the length of absorber element.Specifically, the first lug
The distance that distance collects stick one end is equal to or slightly greater than the length of absorber element, specifically, the collection stick one end is to collect stick end
End.
In some preferred embodiments, the described collector further includes gasket；The gasket has through-hole.
In some preferred embodiments, the through-hole, which passes through collection stick, is connected to gasket on collection stick；Absorber element
Positioned between gasket and the first lug.Gasket, which is connected to, to be collected on stick, is to make to absorb member to limit and fix absorber element
Part, which is not fallen off out, collects stick, while being also that absorber element is further fixed in the position collected on stick, i.e., absorber element is consolidated
Surely it is connected between gasket and the first lug.More specifically, gasket is connected to the one end for collecting stick, it is preferred that gasket connection
In the end for collecting stick.
In some preferred embodiments, in order to not fall off the component being loaded on collection stick, collects stick and be connected with
One end end of absorber element has latch, specifically, collecting the extreme ends of stick has latch, latch protrudes from collection stick
Surface.In some preferred embodiments, latch is two, and two latch positions are symmetrical.In some specific embodiments, card
Tooth is barb-shaped structure.Latch, which is arranged in, collects one end that stick is connected with absorber element, (inhales for stopping to collect the component on stick
Receive element and gasket) it slides out and collects stick.Preferably, stick one end is collected because latch is fixed on, in installation absorption piece and gasket
When, collection stick can be just passed through after needing to initially pass through latch, therefore latch is barb-shaped structure, can make absorption piece and pad
Piece enters not to be hindered when collecting stick end.
In some preferred embodiments, collecting one end end that stick is connected with absorber element has groove.Groove is set
Set and deformed after making to collect this one end of stick and can be compressed into groove, the convenient loading part on collecting stick, such as absorber element and
Gasket.
More preferably in embodiment, latch is located at the two sides for collecting stick portion end groove.That is, the end for collecting stick is recessed
Slot two sides have symmetrical latch.
Preferably, latch and groove, which are located at, collects stick end.
In some preferred embodiments, the gasket, which is buckled in, to be collected at stick end latch.I.e. latch protrudes from collection
The part on stick surface stops gasket, and so that it will not fall off or slide from collection stick.
In some preferred embodiments, the through-hole aperture size is identical as rod outside diameter is collected.That is, through-hole with
Collect stick between gap be zero, gasket will not collect stick on slide, only under external force can collect stick on move down
It is dynamic.
In some preferred embodiments, collecting stick further includes the second lug；It is another that second lug is located at collection stick
Between end and the first lug.
In some preferred embodiments, collecting the stick other end has handle.Handle facilitate operator be affectedly bashful collector into
Row operation.
Preferably, it is top that the collection stick other end, which is collection stick,.
On the other hand, the present invention also provides a kind of sample collection and the devices of detection, including collecting chamber, and, the device
It further include applicator, the applicator includes collecting stick and absorber element, and the absorber element has hollow chamber
Body；The portion collection stick is housed in the hollow cavity of absorber element.
Portion collection stick, which is housed in the hollow cavity of absorber element, makes collection stick be connected with absorber element, that is,
Absorber element is connected to the one end for collecting stick, specifically makes to collect stick one end and is absorbed member with portion collection the stick more than end
The hollow cavity of part is accommodated, meanwhile, absorber element, which is entirely located in, to be collected on stick.
In some preferred embodiments, in order to enable absorber element is not easy to slide on collecting stick, connect therebetween
It is closer, the hollow cavity of absorber element and the cooperation of collection stick zero clearance.That is the structure of the hollow cavity of absorber element and big
Small all identical as collection stick structure and size, hollow cavity inner surface and collection stick outer surface connects.
In some preferred embodiments, collecting has the first lug for stopping and positioning absorber element on stick.This first
Lug limits absorber element and is collecting the position on stick for preventing absorber element from further moving on collecting stick.One
In a little specific embodiments, position of first lug on collection stick is corresponding with the length of absorber element.Specifically, the first lug
The distance that distance collects stick one end is equal to or slightly greater than the length of absorber element, specifically, the collection stick one end is to collect stick end
End.
In some preferred embodiments, the described collection device further includes the gasket with through-hole；The through-hole passes through
Collecting stick is connected to gasket on collection stick；Absorber element is located between gasket and the first lug.More specifically, gasket connects
It connects in the one end for collecting stick, it is preferred that gasket is connected to the end for collecting stick.
In some preferred embodiments, collecting one end end that stick is connected with absorber element has latch, and latch is prominent
In collection stick surface；Collecting one end end that stick is connected with absorber element has groove.The setting of groove makes collection stick end can
It is deformed after being compressed into groove, latch is used for the landing for stopping to collect the component on stick.
In some preferred embodiments, the gasket is buckled in by through-hole and is collected at stick end latch.
In some preferred embodiments, the through-hole aperture of the gasket is identical as rod outside diameter is collected.
In some preferred embodiments, the device of the collection and detection further includes extrusion cylinder, and the extrusion cylinder is fixed
It is connected in collecting chamber.
In some preferred embodiments, the tube port position of the extrusion cylinder has platform.I.e. extrusion cylinder tube port position has water
Flat plane.
In one specific embodiment, collects stick and absorber element is cylinder, extrusion cylinder is cylindrical shape, therefore, platform
For the planar annular for being surrounded on nozzle.
In some preferred embodiments, the height of extrusion cylinder is greater than or equal to the length of absorber element；The extrusion cylinder
Internal diameter be greater than or equal to collect stick diameter.In the present invention, absorber element is made by the cooperation of extrusion cylinder and applicator
On liquid sample be extruded, the structure of applicator according to the present invention, the design of extrusion cylinder be required to compression inhale
Receiving element flows out liquid sample therein, and the sample of outflow can be reached in collecting chamber, and therefore, extrusion cylinder is initially positioned at
In collecting chamber, specifically, extrusion cylinder is fixed in collecting chamber；More specifically, the bottom of extrusion cylinder is located at collecting chamber bottom,
Therebetween it is fixedly connected, it is preferred that the bottom of extrusion cylinder is also possible to a part of collecting chamber bottom；Other embodiments
In, extrusion cylinder is connected on the side wall of collecting chamber adjacent to collecting chamber side, the platform of extrusion cylinder opening.Secondly, extrusion cylinder is logical
The collection stick part for accommodating collector is crossed, while absorber element is blocked in the external realization extruding absorber element of extrusion cylinder to make liquid
The function of outflow, therefore, the tube inner chamber of extrusion cylinder are required to accommodate and collect stick and stop absorber element, thus, extrusion cylinder
Inner cavity shape with collect stick it is identical, size and the collection stick part of receiving are also corresponding mating, i.e. the height of extrusion cylinder be greater than or
Equal to the length of absorber element；The internal diameter of the extrusion cylinder is greater than or equal to the diameter etc. for collecting stick.
In some preferred embodiments, the diameter of gasket is greater than internal diameter of the container.In this way, gasket is blocked in extrusion cylinder
In addition.
In some preferred embodiments, in the applicator insertion collecting chamber, firstly, the absorption member on collector
Part is located at right above extrusion cylinder nozzle；Secondly, the direction that collector continues in insertion extrusion cylinder moves, it is located in absorber element
The empty intracorporal collection stick of chamber enters in extrusion cylinder, and the nozzle platform that the gasket of absorber element bottom is squeezed pressure cylinder stops to squeeze,
Absorber element compresses after being squeezed by nozzle platform and gasket, and liquid is flow to nozzle platform and squeezed after squeezing out in absorber element
On pressure cylinder side wall；Finally, the absorber element of collector is all compressed, liquid is all along nozzle platform and extruding in absorber element
Cylinder side wall is flowed into collecting chamber.
More preferably in embodiment, when collection stick is entered in extrusion cylinder, collects stick end latch and initially enter extruding
It is extruded medial wall of the tube extruding in cylinder, collects stick end to groove variations, enters collection stick end in extrusion cylinder；And then it collects
Stick enters in extrusion cylinder.
In some preferred embodiments, after absorber element is all compressed, collects stick and be fixed in extrusion cylinder by latch.
After collection stick is fixed in collecting chamber, collector will not be made individually to abandon, cause subsequent environmental pollution, it is more environmentally friendly.
In other preferred embodiments, after absorber element is all compressed, the cylinder that stick end reaches extrusion cylinder is collected
Bottom.
In some preferred embodiments, collecting chamber further includes the Ka Gai for receiving simultaneously fixed sample collector, described
Ka Gai is fixed at the accent of collecting chamber.In some preferred embodiments, Ka Gai has the opening for receiving applicator, institute
It is corresponding with extrusion cylinder position to state aperture position；Collector enters after card cover gab positioned at the surface of extrusion cylinder nozzle.
In some preferred embodiments, there is annular lug on card lid inner wall；Collecting has the second lug on stick, described
Second lug, which is located at, to be collected between the stick other end and the first lug；It is described when the second lug reach annular lug at when, collector
It is prevented from going successively in collecting chamber.
It further include test chamber, fluid is connected between test chamber and collecting chamber in some preferred embodiments.
In some preferred embodiments, the side side wall of extrusion cylinder proximity detection chamber has water conservancy diversion slope.The water conservancy diversion slope energy
Enough make to gather more liquid samples on extrusion cylinder lateral wall, to keep more samples quick by water conservancy diversion slope
It is flowed at test chamber, makes detection more rapidly and effectively.
It further include testing element in some preferred embodiments, testing element is located in test chamber.
Beneficial effect
The device and collection detection method more Environmental Safety of applicator and sample collection and detection of the invention,
It is easier to be received by subject, and use is simple laborsaving, and subject is facilitated to operate.
Detailed description of the invention
Fig. 1 is collector schematic diagram of the invention；
Fig. 2 is the decomposition diagram of collector of the invention；
Fig. 3 is collector diagrammatic cross-section of the invention；
Fig. 4 is collector absorber element of the invention by compressed schematic diagram；
Fig. 5 is collector absorber element of the invention by compressed diagrammatic cross-section；
Fig. 6 is the schematic diagram of collection of the invention and detection device；
Fig. 7 is the decomposition diagram of collection of the invention and detection device；
Fig. 8 is the collecting chamber diagrammatic cross-section of collection of the invention and detection device；
Fig. 9 is the diagrammatic cross-section of collection of the invention and detection device collected after sample.
Appended drawing reference:
Applicator 100 collects stick 110, absorber element 120, the hollow cavity 121 of absorber element, gasket 130, pad
Piece through-hole 131, the first lug 111, the second lug 112, handle (collecting stick top) 113 collect stick end 114, end groove
115, end latch 116, the device 800 of sample collection and detection, collecting chamber 200, extrusion cylinder 210, nozzle platform 211, water conservancy diversion
Slope 212, card lid 300, card cover gab 310, the interior convex block 320 of card lid, test chamber 400, testing element 500,
Specific embodiment
Structure of the present invention or technical term used in these are described further below.
Detection
Detection indicates chemical examination or tests a kind of substance or material to whether there is, for example, but it is not limited to this, chemical substance,
Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation
Thank object, nucleic acid, protein or polymer.In addition, detection indicates the quantity of test substances or material.Furtherly, table is gone back in chemical examination
Show immune detection, chemical detection, enzyme detection etc..
Sample
Signified sample of the invention refers to that those can be used to detect, chemically examine or diagnose with the presence or absence of interested analyte
The substance of matter.Sample can be, for example, liquid sample, liquid sample may include blood, blood plasma, serum, urine, saliva and
Various juices can also include the liquid solution that solid sample and semi-solid samples are formed after pre-processing.It collects and
Sample can be used for the methods of immune detection, chemical detection, enzyme detection and detect whether that there are analytes.One preferably
Embodiment in, sample of the invention be saliva sample.
Analyte
It can analyze any analyte with apparatus and method of the present invention.Analyte can in any liquid or
It is detected in person's liquefied sample, such as urine, saliva, saliva, blood, blood plasma or serum.Analyte can also be one
A little haptens substances, these haptens include drugs (such as drug abuse)." drug abuse " (DOA) refers to that non-medical destination makes
With drug (usually playing paralysis nerve).It can be used for detection using the device and belong to medical usage but easy medication
Excessive detection, such as tricyclic antidepressant (imipramine or the like) and Paracetamol.These drugs are absorbed by the body
Different small-molecule substances can be resolved into afterwards, these small-molecule substances be present in the body fluid such as blood, urine, saliva, sweat or
There are above-mentioned small-molecule substances for part body fluid.
Testing element 500
Testing element 500 can select the test strip of lateral flow, it can detect a variety of analytes.Certainly,
He can also be used in the present invention by suitable testing element.Various testing elements can be grouped together and apply to the present invention
In.A kind of form is Test paper.For analyzing the analyte in sample (such as drugs or showing the metabolin of physical condition)
Test paper can be various forms, such as immunoassays or the form of chemical analysis.Test paper can use non-competing method
Or the analytical model of competition law.Test paper includes a water-absorbent material with sample region of acceptance, reagent area and test section.Sample-adding
This flows to reagent area by capillarity to sample region of acceptance.In reagent area, if there is analyte, sample and reagent
In conjunction with.Then sample continues to flow to detection zone.Other reagents, such as molecule with the Non-specific combination of analyte are fixed on
Detection zone.These reagents react with the analyte (if present) in sample and analyte are incorporated in the area, Huo Zheyu
Some reagent of reagent area combines.For showing that the marker of detection signal exists and reagent area or isolated mark zone.
Typical non-competing method analytical model is: if containing analyte in sample, signal will be generated, if do not wrapped
Containing analyte, signal is not just generated.In competition law, if analyte is not present in sample, signal is generated, if deposited
In analyte, then signal is not generated.
Testing element 500 is Test paper, the material that can be selected water suction or not absorb water.Test paper may include a variety of materials
Material is transmitted for liquid sample.The material of one of Test paper can cover on another material, as filter paper is covered on nitre
On acid cellulose film.One area of Test paper can select one or more materials, and another area select other different one
Kind or multiple material.Test paper can be attached on certain support or hard surface and be affectedly bashful Test paper for improving
Intensity.Analyte is detected by signal generating system, such as utilizes one kind that specific reaction occurs with this analyte
Or a variety of enzymes, specific combinating substance is fixed on the method on Test paper using such as aforementioned, one or more signals are occurred
The composition of system is fixed on the analyte detection zone of Test paper.The substance for generating signal can be tried in sample region of acceptance 201
On agent area or detection zone, or entire Test paper, which can be full of on one or more materials of Test paper.It will contain
There is the solution of signal object to be added to the surface of test paper or one or more materials of test paper are immersed in the solution of the object containing signal.Make
The test paper that the solution of object containing signal is added is dry.
Each area of Test paper can arrange in the following manner: sample region of acceptance, reagent area, detection zone, control zone, really
Random sample originally whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas, which can be arranged at, only to be used
On an a kind of test paper of material.It can also be not same district and use different materials.Each area can directly be contacted with liquid sample,
Or direction arrangement of the different areas according to liquid sample flowing, the end in each area is connected and is overlapped with the front end in another area.Institute
Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also be adopted
Use other forms.
Test chamber 400
Test chamber 400 is usually a cavity, for accommodating testing element 500, and liquid sample is made to be able to enter the chamber
Engaged test element is detected in body.Its various shapes, can according to need the testing element of receiving shape and quantity into
Row design.In the present invention, testing element is test strips, and therefore, in one embodiment, test chamber is plank frame, has bottom plate
And upper plate, the two form a cavity after being combined together by way of engaging, more specifically, have one or more on bottom plate
The strip-shaped clamp groove of a protrusion, these card slots are for placing and fixing test strips 500.In other preferred embodiments, upper
There is a window, the window's position is corresponding with the detection zone of test strips, facilitates the test result of observation test strips on plate.
In the following detailed description, the subsidiary reference word of legend is a part here, it is to illustrate this
Invention can the mode of actable specific concrete scheme illustrate.The present invention, which is not precluded, in we can also carry out others specifically
Scheme and change structure of the invention without prejudice to use scope of the invention.
In the present invention, as depicted in figs. 1 and 2, applicator 100 includes absorber element 120 and collects stick 110, is absorbed
Element 120 has hollow cavity 121, and portion collection stick 110 is housed in the hollow cavity 121 of absorber element.It is specific next
It says, the one end for collecting stick 110, which is housed in hollow cavity 121, connect collection stick 110 with absorber element 120.One tool
In the embodiment of body, collecting stick 110 has both ends -- top 113 and end 114, and absorber element 120, which is connected to, collects stick end
114.More specifically, in order to connect absorber element 120 closely with stick 110 is collected, hollow 121 structure of cavity of absorber element
With size and collect stick 121 be inserted into hollow cavity part-structure and size it is all identical.Absorber element 120 is usually by this field
The common other sponge of medical grade or plastic foam material are made.But many other materials may be made as absorption piece, such as
Cotton perhaps paper or other any materials with water absorbing properties.It collects stick 110 to be usually rigid, be conducive to absorption
The operation of element 120.Collecting stick 110 can be made of material commonly used in the art, such as plastics, timber, metal or cardboard.It inhales
The shape for receiving element 120 and collection stick 110 is unlimited, for example, absorber element 120 can be to be spherical, strip, cylinder etc., and
Collecting stick 110 can be cylinder, rectangle, cone etc..In some specific embodiments, collects stick 110 and absorb member
Part 120 is cylindrical structure, also, the hollow cavity 121 of absorber element is also cylindrical cavity.
It is connected to the position collected on stick 110 in order to limit absorber element 120, collecting has the first lug on stick 110
111, which, which is fixed on, collects on stick 110, for stopping absorber element 120 collecting the enterprising moved further of stick 110
To collection stick top.In general, position of first lug 111 on collection stick 110 is corresponding with the length of absorber element 120.Tool
Body, the first lug 111 is equal to or slightly greater than the length of absorber element 120 apart from the distance for collecting stick end 114.Work as collection
After the hollow cavity 121 of absorber element is inserted into stick end 114, absorber element 120 is on collecting stick 110 along collection stick end
114 move to top orientation, are prevented from after reaching at the first lug 111, at this point, absorber element 120, which is entirely located in, collects stick 110
On, and collect stick end 114 and be placed exactly at 120 bottom margin of absorber element that (end 114 protrudes from absorber element slightly
120 bottom margins).Gasket 130, which is mounted on, collects stick end 114, neighbouring or contact with 120 bottom margin of absorber element, preferably
Embodiment in, gasket 130 is contacted with 120 bottom margin of absorber element.At this point, absorber element 120, which is limited at, collects stick 110
The first lug 111 and gasket 130 between.More specifically, the top of absorber element 129 contacts the first lug 111, absorbs member
The bottom contact pins 130 of part 120.There is through-hole 131, collecting stick end 114 across through-hole 131 makes gasket 130 on gasket 130
It is connected and collects on stick 110.Specifically, 131 pore size of through-hole is identical as 110 outer diameter of stick is collected.That is, through-hole
131 and to collect gap between stick 110 be zero, gasket 130 will not slide on collecting stick 110, only under external force can be
It collects and is moved up and down on stick 110.The material of gasket 130 usually requires certain rigidity, can material commonly used in the art be made,
Such as plastics, timber, metal or cardboard etc..In one specific embodiment, gasket 130 is circular configuration.
In some embodiments, in order to make absorber element 120 and gasket 130 not fall off from collection stick 110, the end of stick is collected
Hold 114 ends that there is latch 116, as shown in figure 4, latch 116, which protrudes from, collects 110 surface of stick.In this way, gasket 130 and absorption
Element 120 is located on latch 116.Latch 116 can be one or more in specific embodiment, be distributed in the end for collecting stick
Hold 114 ends, in one embodiment, two latches 116 are symmetrically distributed in 114 end sidewalls of end for collecting stick.Latch
116 shapes to collecting on stick are preferential alternative condition to facilitate installing component, and in some embodiments, latch 116 is barb-shaped knot
Structure.It in other embodiments, is mounted on and is collected on stick 110 in order to facilitate component, consider to collect one end-collection that stick 110 is inserted into
When stick end can have latch 116 with dilatation, especially end, just advantageously, collecting, the setting of stick end is recessed for deformation
Slot 115, as shown in figure 3, when end being made to receive external force, the deformation into groove 116, so that 114 overall volume of end is made to become smaller, side
Just stick 110 is collected to be inserted into absorption piece 120 and gasket 130.In one specific embodiment, latch 116 is symmetrically positioned in end
On the two sidewalls of groove 115, as shown in Figure 5.
In general, collecting also has the second lug 112 on stick 110, which is usually used in collecting in sample and device
In conjunction with fixed collector 100 is carried out, the second lug 112, which is located at, to be collected between stick top and the first lug 111.In some embodiments,
The size of second lug 112 is greater than the first lug 111.In this way, collecting sample when applicator 100 enters collection device 800
When, it can guarantee that the first lug 111 enters collection device and the second lug 112 is prevented from.In some embodiments, stick top is collected
With handle 113, operator is facilitated to be affectedly bashful.
In the present invention, the device 800 of the sample collection and detection that can accommodate applicator of the invention includes collecting
Chamber 200 and applicator 100, as shown in fig. 6, side also has test chamber 400 in collecting chamber 200.In collecting chamber 200 also
There is extrusion cylinder 210, which is fixed in collecting chamber 200, as shown in figure 8, in a specific embodiment, extrusion cylinder 210
The side in collecting chamber 200, extrusion cylinder nozzle platform 211 are connect with 200 inner sidewall of collecting chamber.Tube port position surround and forms ring-type
Platform 211.Collecting chamber 200 is usually a cavity, for accommodating liquid sample, and can accommodate testing element and installation
The structure etc. of testing element.The structure for being flowed into sample in the collecting chamber is also had in some embodiments, in collecting chamber.Or
Person's collecting chamber also has the channel being in fluid communication with testing element.Its various shapes can according to need its function for needing to realize
It can be carried out design.In the embodiment of the present invention, as shown in Figure 6 and Figure 7, collecting chamber 200 is by having a face sidewall plane on bottom wall
It is enclosed with its lap curved wall.The other side in collecting chamber 200 has test chamber 400, is equipped with survey in test chamber 400
Try element 500.Side-walls in 210 proximity detection chamber of extrusion cylinder, 400 side have water conservancy diversion slope 212, are used for liquid on side wall
Fast guiding is at test chamber 400.The extrusion cylinder 210 is used to cooperate with collector 100 to collect the sample in absorber element, and
And extrusion cylinder 210 prevents absorber element 120 from entering for accommodating the collection stick 110 in the hollow cavity 121 of absorber element,
To which the height of extrusion cylinder 210 is greater than or equal to the length of absorber element 120 to guarantee to accommodate the part for being absorbed element containing
Collect stick；The internal diameter of extrusion cylinder 120 is greater than or equal to the diameter for collecting stick 110, can be inserted into extruding to guarantee to collect stick 110
In cylinder 120.At the same time, the diameter of gasket 130 is greater than 210 internal diameter of extrusion cylinder, to make gasket 130 also be blocked in extrusion cylinder
Outside 210, becomes the hard bottom for squeezing absorber element 120, absorber element 120 is made to be easier to be compressed.
Device 800 further includes the card lid 300 for receiving simultaneously fixed sample collector, as shown in FIG. 7 and 8, the card lid 300
Lid close collecting chamber 200 accent, make its closing, specifically, card lid 300 is buckled at 200 accent of collecting chamber, make collecting chamber with
Fixed between card lid, specifically, having the card slot for accommodating 200 accent of collecting chamber on card lid 300, card slot is buckled in accent side wall
On.There is opening 310 on card lid 300,310 position of opening is corresponding with 210 position of extrusion cylinder in collecting chamber, that is, is open
310 centers are being overlapped with 210 center of extrusion cylinder.When collector 100 is entered in collecting chamber 200 by card cover gab 310, it is located at
The absorber element 210 of collector bottom is located at right above 210 nozzle of surge drum.There is cyclic annular convex block 320 on card lid 300, it should
Convex block 320 is prominent into card lid 300.Convex block 320 stops the second lug 112 on the collector in collection, makes collector 100 not
It can be further continued for going deep into collecting chamber 200 and in extrusion cylinder 210.
Just applicator 100 and sample collection and the device of detection 800 of the invention are specifically described in conjunction with Fig. 9 below
The method collected and detect sample.It is specific as follows:
Applicator 100 is installed, the hollow alignment of cavity 121 of absorber element 120 is had into 116 He of latch
The insertion of collection stick end 114 of groove 115 is collected in stick 110, until absorber element 120 reaches at the first lug 111；By gasket
130 alignment of through-hole 131 collects the insertion of end 114 and collects stick 110, is located at gasket 130 at latch 116；
Applicator 100 is put into subject oral cavity (or in the liquid for needing to sample), collects sample, makes to absorb member
Part 120 is full of sample；
The collector 100 of hydraulically full sample is inserted into the suction on collector on collecting chamber 200 in the opening 310 of card lid 300
Element 120 is received to be located at right above 210 nozzle of extrusion cylinder；
So that collector 100 is continued the direction along insertion extrusion cylinder 210 and move insertion, in the cavity hollow positioned at absorber element
Collection stick 110 enter in extrusion cylinder 210, i.e., collection stick end latch 116, which enters in extrusion cylinder 210, is squeezed the inside of pressure cylinder 210
Wall squeezes, and collects stick end 114 and deforms to groove 115, enters collection stick end 114 in extrusion cylinder 210, and then collect stick
110 enter in extrusion cylinder 210；
Meanwhile the gasket 130 of absorber element bottom is squeezed the blocking extruding of nozzle platform 211 of pressure cylinder 210, absorber element
120 are compressed after nozzle platform 211 and the extruding of gasket 130, and liquid is flow to nozzle platform after squeezing out in absorber element 120
211 and 210 side wall of extrusion cylinder on；
When the second lug 112 reaches at annular lug 320, the absorber element 120 of collector is all compressed, and absorbs member
Liquid is flowed into collecting chamber 200 all along nozzle platform 211 and 210 side wall of extrusion cylinder in part 129；
Meanwhile collecting stick end 114 and reaching 210 bottom of extrusion cylinder, stick 110, which is collected, by latch 116 is fixed on extrusion cylinder 210
Interior, collector 100 is prevented from going successively in collecting chamber 200, shown in Fig. 9；
The sample flowing on 210 side wall of nozzle platform 211 and extrusion cylinder is flowed into proximity detection chamber along water conservancy diversion slope 212
It in collecting chamber 200 at 400, then is flowed into test chamber 400, contacts, detected with testing element 500.
Testing result on read test element.
Claims (5)
1. a kind of collection and the method for detecting sample, wherein including the device for collecting and detecting sample, which includes receiving
Collect chamber, the extrusion cylinder in collecting chamber, testing element and applicator；The testing element is connected with collecting chamber fluid
It is logical；Wherein:
Collector is collected into sample, makes the hydraulically full sample of collector；
It will be filled with the extrusion cylinder in the collector insertion collecting chamber of liquid sample, be flowed into sample in collecting chamber；
Make in collecting chamber sample be flowed into testing element to be detected；
Testing result on read test element；
The applicator includes collecting stick and absorber element, and the absorber element has hollow cavity；The collection stick
It is housed in the hollow cavity of absorber element；Collecting has the first lug for stopping and positioning absorber element on stick；Collector
It further include the gasket with through-hole, through-hole, which passes through collection stick, makes gasket be connected to collection stick one end；The absorber element is connected
Between gasket and the first lug；The tube port position of extrusion cylinder has platform；The internal diameter of extrusion cylinder, which is greater than or equal to, collects the straight of stick
Diameter and the diameter for being less than gasket；Wherein:
When collector collects sample, make the hydraulically full sample of absorber element；
After collector is inserted into collecting chamber, it is located at the absorber element on collector right above extrusion cylinder nozzle；Make to receive again
Storage continues the direction along insertion extrusion cylinder and moves, and the intracorporal collection stick of the chamber hollow positioned at absorber element enters in extrusion cylinder,
The nozzle platform that the gasket of absorber element bottom is squeezed pressure cylinder stops, and absorber element compresses after being squeezed by nozzle platform and gasket,
Liquid is flow on nozzle platform and extrusion cylinder side wall after squeezing out in absorber element.
2. the method according to claim 1, wherein the height of extrusion cylinder is greater than or equal to the length of absorber element
Degree；Wherein:
The collection stick being housed in absorber element fully enters in surge drum, and absorber element is all compressed, liquid in absorber element
Body is flowed into collecting chamber all along nozzle platform and extrusion cylinder side wall.
3. the method according to claim 1, wherein collecting one end end that stick is connected to absorber element has card
Tooth, latch, which protrudes from, collects stick surface；Collecting one end end that stick is connected to absorber element has groove；Wherein:
Collector continues to squeeze direction in card cylinder along insertion and moves, and collection stick end latch, which enters in extrusion cylinder, to be squeezed on the inside of pressure cylinder
Wall squeezes, and collecting stick end enters collection stick end in extrusion cylinder to groove variations, and then collects stick and enter in extrusion cylinder；
After absorber element is all compressed, one end end arrival extrusion cylinder bottom that stick is connected with absorber element is collected, stick is collected
It is fixed in extrusion cylinder by latch.
4. the method according to claim 1, wherein the device further includes test chamber, test chamber and collecting chamber stream
Body is connected；Testing element is located in test chamber.
5. method according to claim 1 or 3, which is characterized in that the device further includes Ka Gai, and Ka Gai lid, which closes, is fixed on receipts
Collect at chamber accent；Card, which covers, has opening, and aperture position is corresponding with extrusion cylinder position；Card, which covers, has cyclic annular convex block, collects stick
Upper to have the second protrusion, the second protrusion is located at the first protrusion and collects between the stick other end；Wherein:
It is located at the surface of extrusion cylinder nozzle after the collector insertion card cover gab；
When the second lug reaches at annular lug, absorber element is all compressed, and collector is prevented from going successively to collecting
It is intracavitary.
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| CN201710241346.4A CN107238697B (en) | 2017-04-13 | 2017-04-13 | A method of it collects and detects sample |
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| CN201710241346.4A CN107238697B (en) | 2017-04-13 | 2017-04-13 | A method of it collects and detects sample |
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| CN107238697B true CN107238697B (en) | 2019-04-16 |
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| CN107036847A (en) * | 2017-04-13 | 2017-08-11 | 杭州旭科生物技术有限公司 | A kind of applicator |
| CN108318482A (en) * | 2018-03-07 | 2018-07-24 | 广州浩强生物科技有限公司 | A kind of saliva detection device and its detection method |
| CN110338849A (en) * | 2018-04-08 | 2019-10-18 | 迈博高分子材料（宁波）有限公司 | A kind of saliva collecting device |
| CN110389049A (en) * | 2018-04-20 | 2019-10-29 | 艾博生物医药(杭州)有限公司 | A kind of sample collection detection device |
| CN112034150A (en) * | 2019-06-03 | 2020-12-04 | 杭州安旭科技有限公司 | Sample collection and detection device and method |
| CN110477958B (en) * | 2019-08-09 | 2021-05-25 | 杭州安旭生物科技股份有限公司 | Method for collecting and detecting sample |
| CN113116393A (en) * | 2019-08-09 | 2021-07-16 | 杭州安旭生物科技股份有限公司 | Sample collecting and detecting device |
| CN111707810A (en) * | 2020-05-11 | 2020-09-25 | 杭州博拓生物科技股份有限公司 | Sample detection device and application method thereof |
| CA3131957A1 (en) * | 2021-04-07 | 2022-10-07 | Assure Tech. (Hangzhou) Co., Ltd. | Blood collection structure and whole blood and fingertip blood testing device and testing method |
| CN115993302B (en) * | 2023-03-22 | 2023-06-13 | 中铁工程服务有限公司 | Shield tail grease detection device and detection method |
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