CN105814430A - Device and method - Google Patents
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- CN105814430A CN105814430A CN201480065961.9A CN201480065961A CN105814430A CN 105814430 A CN105814430 A CN 105814430A CN 201480065961 A CN201480065961 A CN 201480065961A CN 105814430 A CN105814430 A CN 105814430A
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Abstract
The invention relates to a device comprises a first cavity (300) and a second cavity (400), wherein the first cavity (300) is positioned in the second cavity (400), and may seal and compress the second cavity (400) so that the liquid in the second cavity (400) is discharged out quantitatively. The device may fully mix a buffer solution with a sample and achieves the function of integration of collection and test. Further, a collecting device also may achieve the quota-sampling function.
Description
Technical field
The present invention relates to a kind of apparatus and method, particularly collect the device and method of sample, and after collection sample, detect the apparatus and method of sample simultaneously.
Background technology
Following background technology is adapted to assist in the reader understanding present invention, and is not construed as prior art.
In our society, illicit drug use has had become as a social problem generally acknowledged and increasingly worsen.2003, U.S. Department of Health and Human Service investigation discovery there are about 19,500,000 Americans or 8.2% age crowd more than 12 years old is sucking illicit drugs." use illicit drugs recently " and refer to carry out investigating in the previous moon at U.S. Department of Health and Human Service and use a kind of illicit drugs.Fructus Cannabis is found to be the most frequently used illicit drugs, accounts for 6.2% (14,600,000).Estimating that 2,300,000 people (1.0%) are currently in use cocaine now, 604,000 people employ KUAIKE, have 1,000,000 people to use hallucinogen, and estimate that 119,000 people are currently in use heroin.
US Patent No. 2004/0184954 and US2004/0237674 disclose other and collect saliva and carry out whether containing in detection saliva the device of illicit drugs composition.In the two patent, both provide the apparatus and method collected and detect saliva, in these devices, after sample is sampled on catcher, by applying external force, the sample in absorption piece on catcher is expressed in collecting chamber, then detects again.But, applicator is coordinating in extrusion process with collecting chamber, it is possible to has sample contact and pollutes to operator or infect；Further, when running into sample and needing first and detect after buffer mixing again, such collection device just seems not very convenient.
It addition, in some detections, sample needs to carry out processing and can be detected.Such as, add buffer solution in the sample, make sample be diluted reducing viscosity, it is ensured that sample can dialysis etc. smoothly on detector bar.Buffer solution how can be made to mix smoothly with sample, and mixing fully and conveniently operates the problem being all to need to solve.
In other detections, in order to ensure the accuracy of detection, it is necessary to detected sample size is quantitative, detect to prevent very few sample size from can not complete and too much sample size can produce Flooding phenomenon, affect the accuracy of testing result.
It is thus desirable to sample is collected and detects by better method and device.
Summary of the invention
The present invention provides the device of a kind of improvement, and this device is capable of quantitative sample and enters in detecting element, solves that sample size is too much or the very few testing result caused is incorrect or inaccurate；Meanwhile, this device applies also for sample needs the detection of pretreatment.
A kind of sample collection device provided by the invention, including applicator, wherein, catcher has sealing cavity.
Preferably, seal cavity to be connected by channel liquid with the absorber element on catcher.
Preferably, this device also includes a lid, and lid forms the sealing cavity on catcher with catcher.
Preferably, lid is detachable connection with catcher.
Preferably, lid is achieved a fixed connection and separates by the moving element on catcher with the through hole cooperation of lid with catcher.
Preferably, when moving element is positioned at the hole on lid, lid is fixing with catcher to be connected；When moving element departs from the hole on lid, can rotate between lid and catcher.
Preferably, by the movement between lid and catcher, the volume of sealing cavity is made to reduce or increase.
Preferably, by the movement between lid and catcher, sealing cavity is made to be connected by passage with the absorber element of catcher.
Preferably, described passage includes the collection bar of hollow, collects bar one end and connects absorber element, and the other end is sealed and connects sealing cavity.
Preferably, poking, by the projection in annular seal space body, the diaphragm seal collecting masthead end makes sealing cavity connect with collection bar and the absorber element of hollow.In one specific embodiment, projection is positioned at the inner tip of lid, is positioned at annular seal space body simultaneously.
Preferably, in annular seal space body, there is buffer solution.
Device provided by the invention, including the first cavity and the second cavity, wherein, the first cavity is positioned at the second cavity；Described first cavity can seal the second cavity；Further, the first cavity can compress the second cavity and makes the liquid in the second cavity by quantitative discharge.
Preferably, the first cavity and the second cavity are for being flexibly connected.Preferably, when the first cavity and the second cavity are fixed and connected, the second cavity is unsealed；After the first cavity and the second cavity separate, the second cavity is sealed by the first cavity and compression.
Preferably, the first cavity and the second cavity can be mutually shifted between the first cavity and the second cavity after separating.
Preferably, the first cavity has primary importance and the second position on the second cavity.Preferably, when the first cavity is positioned at primary importance, the first cavity seals the second cavity, forms the cavity sealed.Preferably, when the first cavity is positioned at the second position, the cavity of sealing is compressed by the first cavity, and the liquid in annular seal space body is quantitatively discharged.
Specifically, when sample is not collected, connects for fixing between two cavitys, facilitate the collection of liquid sample；And be collected in the first cavity and the second cavity when sample after, by the change of position between the first cavity and the second cavity, namely the first cavity rotates on the second cavity, liquid is sealed in the second cavity, compressed, be finally discharged the second cavity again, it is achieved the function of quantitative sample injection.Specifically, after two cavitys depart from fixing connection, first rotate the first cavity and make it lower mobile mutually along the second inside cavity, when arriving first position, the second cavity is sealed；More specifically, having a little cavity at the second cavity bottom, this little cavity is sealed by the first cavity, forms the cavity of a sealing holding sample.Be rotated further by first cavity second position to the second cavity, then, the first cavity continues to move down, and the little cavity volume of sealing is compressed, and the liquid of respective amount then discharged by the sample wherein sealed according to the size of volume compression.Because the spacing of primary importance to the second position is fixed, so the volume size compressed of the cavity sealed is fixed, thus the amount of liquid got rid of also is fixing, it is discharged thus implementing quantitative sample, it is achieved the function of quantitative sample injection.
Preferably, make the fixing connection of two cavitys and separate with the connection of the through hole of the second cavity with separating by the first projection of rib on the first cavity.
Preferably, this device also includes applicator, and this catcher has sealing cavity.Preferably, seal cavity to be connected by channel liquid with the absorber element on catcher.
Preferably, this device also includes a lid, and lid forms the sealing cavity on catcher with catcher.Preferably, this annular seal space body is positioned at lid, and namely the top of catcher is positioned at lid the sealing cavity being formed on catcher.Namely lid and collection masthead end are tightly connected, form the annular seal space being positioned at lid.
Preferably, lid is detachable connection with catcher.Namely the two is for being flexibly connected.
Preferably, lid is achieved a fixed connection and separates by the moving element on catcher with the through hole cooperation of lid with catcher.
Preferably, when moving element is positioned at the hole on lid, lid is fixing with catcher to be connected；When moving element departs from the hole on lid, can move between lid and catcher.
Preferably, by the movement between lid and catcher, the volume of sealing cavity is made to reduce or increase.
Preferably, by the movement between lid and catcher, sealing cavity is made to be connected by passage with the absorber element of catcher.
Preferably, described passage includes the collection bar of hollow, collects bar one end and connects absorber element, and the other end is sealed and connects sealing cavity.
Preferably, poking, by the projection in annular seal space body, the diaphragm seal collecting masthead end makes sealing cavity connect with collection bar and the absorber element of hollow.In one specific embodiment, projection is positioned at the inner tip of lid, is positioned at annular seal space body simultaneously.
Preferably, this device also includes test chamber, and test chamber is connected with the sealing cavity of the second cavity.
Preferably, when lid and the catcher of fixing connection insert after in the first cavity, catcher is positioned at the first cavity and seals the first cavity；Lid is between the first cavity and the second cavity.
Preferably, the first cavity forces the moving element of catcher to depart from the through hole on lid.
Preferably, when lid is moved relative to catcher, the sealing cavity on catcher that lid and catcher are formed is compressed, the projection contacts on top poke the diaphragm seal collecting masthead end in lid, seals cavity and is connected with the cavity of collection bar.
Preferably, sealing in cavity and include buffer solution, when this sealing cavity is connected with the cavity of sample collection bar, buffer solution is flowed on absorber element by the cavity connected.Buffer solution is flowed on absorber element, mixes with the sample being positioned on absorber element, completes the pretreatment of sample.
Preferably, lid forces the first protruding through hole departing from the second cavity of the rib of the first cavity.
Preferably, the rib of the first cavity including the second projection, lid oppresses the second projection makes rib bounce back；The thereon first protruding through hole departed from the second cavity after rib retraction.So, the first cavity and the second cavity depart from and connect, and can be mutually shifted or rotate therebetween.
Preferably, when applicator rotates together with lid in the first chamber and the second cavity, absorber element is compressed in the first cavity, and liquid flows in the first cavity and the second cavity；First cavity moves to reach the primary importance of the second cavity along with lid together with catcher, and the first cavity seals the second cavity and forms sealing cavity.Preferably, when the first cavity rotates the second position arriving the second cavity together with lid, sealing cavity and compressed, the liquid quantitative in annular seal space body enters test chamber.
Preferably, cover outer surface and the second cavity inner surface have the screw thread being mutually twisted.
On the other hand, the present invention also provides for a kind of method collecting sample, and including providing a kind of device collecting sample, this device includes the first cavity and the second cavity, and the first cavity is positioned at the second cavity, and the two is detachable connection and liquid communication；Described first cavity can seal and compress the second cavity makes the liquid quantitative in the second cavity discharge.
Preferably, the first cavity can rotate mutually with the second cavity；Making the first cavity turn to the primary importance of the second cavity, the second cavity is sealed by the first cavity.
Preferably, making the first cavity turn to the second position of the second cavity, the second cavity of sealing is compressed, and makes its interior liquid quantitatively be discharged.
Preferably, this device also includes applicator and the lid of movable connection；Applicator includes the collection bar of hollow, collects masthead end and is sealed by diaphragm seal, and end is connected with absorber element and connects；Lid forms, with collecting masthead end, the annular seal space being positioned on catcher.
Preferably, the applicator of fixing connection and lid is made to be inserted in the first cavity and the second cavity；Rotating cover, the moving element in the first cavity compressing applicator forces applicator to depart from fixing connection with lid.
Preferably, being rotated further by lid, make lid and applicator mutually rotate, the sealing cavity on catcher is compressed, the projection contacts on top poke the diaphragm seal collecting bar masthead end in lid, seals cavity and is connected with the cavity of collection bar；The buffer being positioned at annular seal space body is flowed on absorber element by the cavity connected.
In superincumbent process, while the movement between lid and catcher, the bottom to the first cavity and the second cavity is moved, and catcher is constant relative to the first cavity position, namely will not be moved.
Preferably, being rotated further by lid, lid oppresses the rib on the first cavity forces the first cavity of detachable connection to depart from the second cavity.
Preferably, being rotated further by lid, lid rotates together with applicator in the first cavity and the second cavity, and absorber element is compressed in the first cavity, and liquid flows in the first cavity and the second cavity；First cavity moves to reach the primary importance of the second cavity along with lid together with catcher, and the second cavity is sealed to be formed and seals cavity by the first cavity.
Preferably, being rotated further by lid, make the first cavity move to the second position in the second cavity, seal cavity and compressed, the liquid quantitative in annular seal space body enters and is attached thereto logical test chamber.
Beneficial effect
Passing through apparatus and method of the present invention, it is possible to mixed fully with sample by buffer solution, and realize the collection of sample and the function of detection integration, meanwhile, this collection device can also realize the function of quantitative sample injection.
Accompanying drawing explanation
Fig. 1 is the exploded perspective view of a device of the present invention；
Fig. 2 is parts---the schematic diagram of lid of apparatus of the present invention；
Fig. 3 is another parts of apparatus of the present invention---the schematic diagram of catcher；
Fig. 4 is the schematic diagram that the parts of Fig. 2 and Fig. 3 are fixed together；
Fig. 5 is another parts of apparatus of the present invention---the schematic diagram of the first cavity；
Fig. 6 is another parts of apparatus of the present invention---the schematic diagram of the second cavity；
Fig. 7 is the schematic diagram of the collection chamber after the unit construction of Fig. 5 and Fig. 6；
Fig. 8-Figure 21 is the schematic diagram of the section in A-A and the B-B direction of the operating process of apparatus of the present invention, and wherein A-A direction and B-B direction are orthogonal both direction；
Fig. 8 is the A-A generalized section that lid of the present invention covers on the first cavity and the second cavity；
Fig. 9 is the B-B generalized section that lid of the present invention covers on the first cavity and the second cavity；
Figure 10 is the A-A generalized section that lid of the present invention turns to a position (the first cavity compressing moving element makes catcher depart from lid) of the first cavity and the second cavity；
Figure 11 is the B-B generalized section that lid of the present invention turns to a position (the first cavity compressing moving element makes catcher depart from lid) of the first cavity and the second cavity；
Figure 12 is the A-A generalized section that lid of the present invention turns to another position (lid projection is poked and collected masthead portion) of the first cavity and the second cavity；
Figure 13 is the B-B generalized section that lid of the present invention turns to another position (lid projection is poked and collected masthead portion) of the first cavity and the second cavity；
Figure 14 is the A-A generalized section that lid of the present invention turns to another position (lid oppresses the first cavity rib forces the first cavity to depart from the second cavity) of the first cavity and the second cavity；
Figure 15 is the B-B generalized section that lid of the present invention turns to another position (lid oppresses the first cavity rib forces the first cavity to depart from the second cavity) of the first cavity and the second cavity；
Figure 16 is the A-A generalized section that the present invention the first cavity is positioned at the primary importance (absorber element is compressed, and the first cavity seals the second cavity) of the second cavity；
Figure 17 is the B-B generalized section that the present invention the first cavity is positioned at the primary importance (absorber element is compressed, and the first cavity seals the second cavity) of the second cavity；
Figure 18 is the A-A generalized section that the present invention the first cavity is positioned at that the second position (annular seal space is compressed) of the second cavity is put；
Figure 19 is the B-B generalized section that the present invention the first cavity is positioned at the second position (annular seal space is compressed) of the second cavity；
Figure 20 is the inverted A-A generalized sections of apparatus of the present invention；
Figure 21 is the inverted B-B generalized sections of apparatus of the present invention；
Description of reference numerals:
Collection device 800；Lid 100；Lid bottom 109；Lid and catcher connecting hole 101；Cap aperture 103；Perforate plug 102；External screw thread 105 on lid；Lid top 104；Lid bottom 110；The projection 111 that top joins with bottom；Liquid storage cylinder 107 in lid；Top projection 106 in lid；The annular seal space 108 that lid is formed with catcher；The opening part 109 of lid；Applicator 200；Catcher end sealing film 201；The sealing ring 202 that catcher coordinates with lid；Catcher internal cavity 210；Hold the groove 203 of lid internal projection；Collect bar (hollow) 205；The moving element (spring) 204 being connected with collection bar；The platform 2041 of spring；Hold the circular discs 209 of packing ring 202；Absorber element 207；The packing ring 208 that catcher and the first cavity coordinate；Hold the circular discs 206 of packing ring 208；First cavity 300；Second cavity 400；First cavity accent 305；First cavity upper cavity 302；Cavity 303 in first cavity；First cavity lower chamber 306；Rib 310 on first cavity；Rib the second projection 311；Rib the first projection 312；The seal washer 301 that first cavity and the second cavity coordinate；Hold the groove 304 of seal washer 301；The hole 307 of the first cavity and the connection of the second cavity；Second cavity female thread 402；Base 401；Receive the hole 405 that rib is protruding；Second cavity upper cavity 403；Second cavity lower chamber 404；Little cavity 406 in second cavity；The accent 4061 of little cavity；The hole 408 that second cavity connects with test chamber；Test chamber 500, detects plate upper cover 502；Detection plate lower cover 501；Detecting element 600；
Detailed description of the invention
Applicator 200
Generally, applicator 200 includes absorber element 207 and collects bar 205, and absorber element 207 is positioned at the one end collecting bar 205, as shown in Figure 3.Absorber element 207 is generally made up of the other sponge of medical grade commonly used in the art or plastic foam material.But many other materials may be made as absorber element, for instance Cotton Gossypii or paper, or other any materials with water absorbing properties.The portion of being affectedly bashful is usually rigidity, is conducive to the operation to absorber element.In certain embodiments, collecting bar and also also serve as the portion of being affectedly bashful, the portion of being affectedly bashful can be made up of material commonly used in the art, for instance plastics, timber, metal or cardboard.In one preferred embodiment of the present invention, in order to enable the sample on absorber element pretreated, also including annular seal space on the collector, this annular seal space processes the buffer solution of sample for laying.Preferably, this sealing cavity can liquid communication with absorber element in " specific situation "." specific situation " refers to when needs sample mixes with buffer solution.Preferably, seal cavity to be connected with absorber element by " passage ".In concrete mode, this passage is the collection bar of hollow, and annular seal space body is arranged in collection bar one end of control, and absorber element is positioned at hollow and collects the bar other end.When sample needs pretreated, sealing cavity and connected with absorber element by the collection bar of hollow, buffering liquid is flowed on absorber element.
Preferably, collection bar 205 other end of applicator 200 is connected to lid 100, and as shown in Figure 4, this lid can have the function in the portion of being affectedly bashful concurrently.Further, annular seal space 108 is to be coordinated, from what collect bar 205 and lid 100, the cavity formed in lid.The bar of collecting of hollow connects with the cavity 108 of lid；Further, the cavity of this collection bar is connected with absorber element 207.More specifically in embodiment, the top collecting bar has diaphragm seal 201, and this diaphragm seal 201 separates collecting the bar cavity cavity 108 with lid.In some specific embodiments, when under " particular case ", when namely sample needs pretreatment, it is possible to by the mode that diaphragm seal 201 is poked makes collection bar cavity 205 be connected with lid cavity 108, as shown in figure 11.Some preferred embodiment in, in order to ensure being flexibly connected of catcher and lid, catcher also has moving element, is coordinated with lid by moving element, carry out the fixing of the two or separate.This moving element 204 can be subjected to displacement within the specific limits.Generally, moving element has elasticity, and its one end is connected on collection bar, and the other end can produce mobile when receiving pressure.In one specific embodiment, moving element is spring 204, and this spring 204 is for being connected with collection chamber 300.In one specific embodiment, spring 204 is two, and these two springs 204 are symmetrically located in the middle part collecting bar 205.Spring 204 be shaped as hook-type, the change of position can be there is when spring 204 runs into pressure, that is, when applicator 200 is positioned at collecting chamber 200, when spring 204 is subject to the pressure from collecting chamber 300, spring 204 can automatic rebounding so that catcher 200 can in collecting chamber 300 freely occur position movement.In another specific embodiment, catcher 200 is connected by spring 204 is fixing with lid 100.When there is the unknown skew after spring 204 stress, spring 204 leaves lid 100, and lid 100 departs from the fixing relation being connected with catcher 200.
Lid 100
In the present invention, also including a lid 100, this lid is used for sealing collection chamber 300, as shown in Figure 2.In one specific embodiment, lid 100 is connected with catcher 200 and connects.More specifically in embodiment, lid 100 is with catcher 200 for being flexibly connected, and in an operating process, lid 100 is connected for fixing with catcher 200；And in another process, lid 100 is connected for unfixing with catcher 200.Preferably, lid having and coordinates, with the moving element on catcher, the through hole making the two fix or separating, in specific embodiment, through hole is 2, identical with the moving element quantity on catcher.After catcher inserts lid, the cylinder on catcher top and lid medial wall cooperatively form sealing, namely form the cavity 204 sealed, and catcher continues in lid deeply mobile, the end thereof contacts of the opening collecting the moving element on bar to the through hole on lid and enters in through hole, is formed fixing.Now, catcher and lid position are fixed, and collect the volume sealing cavity above bar and also fix.
Preferably, in order to ensure that sealing cavity connects when needs with absorber element, in the annular seal space body on lid, namely lid portion inside tip designs has projection, and one end of this projection is sharp-pointed, it is possible to poke materials such as including aluminium foil, paper, plastic sheeting.When sample needs pretreatment, then make this projection contacts to collect masthead end diaphragm seal so that it is poke diaphragm seal, so that annular seal space connects with collection bar cavity.In one specific embodiment, by the mutual rotation between lid and catcher, the cavity making sealing is compressed, volume diminishes, lid top distance is collected the distance of masthead end and is reduced, the projection contacts on lid top also oppresses the diaphragm seal collecting masthead end, pokes the connection that diaphragm seal realizes between cavity.
In one embodiment, on lid 100 lateral wall, there is the screw thread 105 coordinated with collection chamber.In other embodiments, the inner tip of lid also includes a liquid storage cylinder 107, and this liquid storage cylinder 107 is for storing liquid sample unnecessary after after testing.More specifically in mode, lid 100 also has an opening 103 in liquid storage cylinder 107 corresponding position, can be taken out by the liquid in liquid storage cylinder 107 by this opening 103 and again detect confirmation.
Collection chamber (the first cavity, the second cavity)
Generally, collection chamber is used for accepting liquid sample, and connects with test chamber 500, and sample is sent on detecting element 600 and completes detection the most at last.In specific embodiment, collection chamber is enclosed by sidewall and bottom and forms, and has an opening, and opening is used for accepting sample.In the present invention, in order to realize the function of quantitative sample injection, collection chamber is split-type structural, is specifically made up of two cavitys, the first cavity 300 and the second cavity 400.
As shown in Figure 5 and Figure 6, wherein, it is internal that the first cavity 300 is positioned at the second cavity 400, and, it is connected between two cavitys, as shown in Figure 7.Concrete, at the first cavity bottom, there is through hole, by this through hole 307, first cavity and the second cavity are connected.Preferably, this through hole 307 is sealed when the first cavity seals and compresses the second cavity.As it is shown in figure 5, the first cavity bottom has a little cavity 306, this little cavity 306 opening and the first cavity in opposite direction, namely opening down, cut off by bottom with middle cavity above, only connected by through hole；In second cavity, the bottom space at cavity is obviously reduced, and forms another little cavity 406；When the first cavity seals the second cavity, little cavity 306 is positioned at the little cavity 406 of the second cavity bottom, and, the top of the little cavity 306 of the first cavity seals the lower chamber 406 of the second cavity, forms the cavity sealed.When the first cavity compresses the second cavity, the little cavity 306 of the first cavity moves to bottom in the inner chamber body 406 of the second cavity, and the top compression of little cavity 306 seals cavity 406.More excellent, when having liquid in sealing cavity 406, liquid is compressed.
In one embodiment, the first cavity 300 is detachable connection with the second cavity 400, namely be flexibly connected, under a state, two cavitys are fixed together, under another state, two cavitys are mutually disengaged, and can be mutually shifted therebetween.In another specific embodiment, the first cavity 300 is connected with the second cavity 400 by the first protruding 312 of the rib of the first cavity and fixes.Preferably, this rib has elasticity, facilitates rib and protruding retraction thereon.In some specific embodiments, this rib is positioned on the first cavity, is a part for the first cavity, but only one end is connected with the first cavity, remainder hollow out.This structure can effectively increase the elasticity of rib, be rib when running into pressure, position changes.
In other embodiments, when first cavity is positioned at position (primary importance) of the second cavity, first cavity and the second chamber inner sidewall are formed and seal, second cavity is sealed, more specifically, an airtight cavity 406 is formed between first cavity and the second cavity, this airtight cavity and the first cavity are connected by through hole 307, after this through hole 307 is sealed, airtight cavity 406 forms, with test chamber 500, the space sealed, because the air in sealing space is a certain amount of, when the air compressed in this sealing space, can make to be positioned at the entrance test chamber of the liquid quantitative of airtight cavity, thus realizing the function of quantitative sample injection.
Below the structure that the present invention relates to or these technical terms used are described further.In the following detailed description, the subsidiary reference word of legend is a part here, and it is to illustrate that the present invention can illustrate in the way of actable specific concrete scheme.We are not precluded from the present invention and can also carry out other concrete scheme and change the structure of the present invention when without prejudice to the use scope of the present invention.
As it is shown in figure 1, the present invention concrete collection device is 800, this device includes four parts: lid 100, catcher 200, the first cavity 300 and the second cavity 400.By the cooperation of these four parts, realize the sample of this device and the mixing of buffer, the function such as detection of the collection of sample mixed liquor and the quantitative sample injection of sample and sample.
As in figure 2 it is shown, lid 100 is divided into upper and lower two parts, i.e. lid top 104；Lid bottom 110；Wherein, top 104 is less than bottom 110, and therefore, top 104 and junction, bottom 110 have the ring-shaped platform 111 of projection.Have a liquid storage cylinder 107 in the inner side on lid top, this cavity 107 is in communication with the outside by a perforate 103, this liquid storage cylinder 107 be used for storing detection after remaining sample, reaffirm that detection uses to facilitate.Perforate 103 includes a perforate plug 102, by this perforate plug 102, liquid storage cylinder 107 and lid 100 is sealed.Additionally, the middle position of lid bottom 110 also has two symmetrical holes 101, this hole 101 is for being connected with catcher 200 and making the two fix.In some specific embodiments, also there is a projection 106 on the top within lid 100, as shown in Figure 9.Meanwhile, in order to realize coordinating of lid 100 and collecting chamber, and lid can seal collecting chamber, and the lower outside at lid 100 also has screw thread 105.
As it is shown on figure 3, applicator 200 is by collecting bar 205 and forming with collecting the absorber element 207 that is connected of bar one end, and, at the other end collecting bar 205, there is a rounded face 209, for and lid 100 form sealing.The sidewall contacted with lid in rounded face 209 has groove and is positioned at the sealing ring 202 of groove.The diameter of the rounded face 209 collecting bar is identical with the internal diameter on lid top 104, thus when catcher 200 is connected with lid 100, the upper interior portion of the rounded face 209 and lid of collecting bar closely cooperates, and the packing ring 202 being located in rounded face forms sealing with lid upper inner wall, thus, form a cavity 108 sealed collecting bar 205 top with lid portion inside.In one specific embodiment, the bar 205 of collecting of catcher is the structure of hollow, is made by the part of this hollow the top of catcher be connected with bottoms liquid, is namely connected with the absorber element 207 of bottom.On the top of catcher 205, there is a diaphragm seal 201 hollow space of catcher 200 is sealed.Diaphragm seal material can use plastics, has the film or paper etc. of sealing function, and it can meet two functions: liquid seal and can being poked by sticker.In one embodiment, also having, on the hollow space top collecting bar, the groove 203 holding lid internal projection, when lid and catcher are positioned under a kind of connection status, the projection 106 on lid pokes the diaphragm seal 201 on top, and is positioned at this groove 203.In some specific embodiments, catcher 200 also having two symmetrical springs 204, this spring 204 has the function of retraction when running into pressure.This spring 204 is barb shape, has a little platform at end.On catcher 200, in order to make absorber element 207 can be sealed in collecting chamber, above absorber element 207, also include the disk 206 identical with collecting chamber internal diameter, fluted in the design of disk side, there is in groove the sealing ring 208 that can seal collection chamber.
As shown in Figure 4, when lid and catcher in conjunction with time, the rounded face on catcher top is entered in lid by the opening 109 of lid, rounded face is by the ring-shaped platform of arrival top and the bottom, lid bottom, start the top 104 of sealing cover body, continue to press on catcher 200, until the platform 2041 of the spring on catcher is positioned on the through hole 101 in the middle part of lid, the two is now in stationary state, and when catcher 200 is positioned at lid 100, therebetween forming a cavity 108 sealed, this cavity is the cavity 108 for laying buffer solution.
As it is shown in figure 5, the first cavity 300 includes upper cavity 302, middle cavity 303 and lower chamber 306 3 part, and, three cavity diameters from top to bottom are sequentially reduced.Separated by dividing plate between middle cavity 303 and lower chamber 306, dividing plate has through hole 307 to ensure the connection of three cavitys.Wherein, upper cavity 302 have two symmetrical ribs 310.This rib 310 is connected with cavity 300 for one end, and remainder is not connected with cavity 300, and when rib 310 runs into pressure, the position of rib 310 can offset.Rib 310 has two projections, is the second protruding 311 and first projection 312 respectively.Wherein, first protruding 312 is used for the connection of this cavity and the second cavity 400.In one embodiment, having groove 304 in the junction of middle cavity 303 with lower chamber 306 and be positioned at the seal washer 301 of groove, when the first cavity is positioned at the second inside cavity, packing ring 301 seals the medial wall of the second cavity.
In figure 6, the second cavity 400 includes upper cavity 403 and lower chamber 404, and the top, inner side of upper cavity has screw thread 402, and this screw thread 402 is corresponding with the screw thread 105 outside lid.In the outside of the second cavity, also having pattern detection chamber 500, this test chamber 500 is connected by through hole 408 with the second cavity 400, it is ensured that the liquid being positioned at the second cavity 400 can be flowed into test chamber 500 by through hole 408.In the bottom of the second cavity, there is base 401.Upper cavity 403 also has the hole 405 of the rib 310 connecting the first cavity, when the first cavity 300 is positioned at the second cavity 400, first projection 312 of the rib on the first cavity is positioned on the hole 405 of the second cavity, now, first cavity 300 is fixed in the second cavity 400, as shown in Figure 7.As shown in Figure 8, also having a little cavity 406 in the second cavity lower chamber 404 inner bottom, the external diameter of the internal diameter of this cavity and the lower chamber 306 of the first cavity is identical, for holding lower chamber 306 and forming sidewall sealing with the sealing ring 301 above lower chamber.
Also shown in FIG. 6, detecting element 600 can be placed in test chamber 500, for detecting the sample being flowed in test chamber.In one specific embodiment, placing a detection plate in this test chamber, detecting element 600 is placed in by detection plate by upper plate 501 and covering of lower plate 502.
Specific operation process with regard to this collection device 800 is described in detail below.Fig. 8-Figure 21 describes the particular state of collection device after the operating procedure of this sample collection device and each operating procedure by the mode of generalized section.When original state, lid 100 is connected with catcher 200 and fixes each other by spring 204, now, has buffer solution in the cavity 108 sealed；First cavity 300 is positioned at the second cavity 400 and is mutually permanently connected by rib 310, and now, in the upper cavity 302 of the first cavity and part, cavity 303 is positioned at the upper cavity 403 of the second cavity, and remainder is positioned at the lower chamber 404 of the second cavity；After the absorber element 207 in applicator gathers sample, such as saliva sample, lid 100 is allowed to cover on collecting chamber, now, applicator 200 is positioned at the first cavity 300, and the opening 109 of lid is positioned at the centre of the first cavity 300 and the second cavity 400, as shown in Figure 8, meanwhile, the first cavity 300 also is located between lid 100 and applicator 200；Now, lid 100 and catcher 200 the buffer solution laying buffering in the sealing cavity 108 formed is connected；Further, as it is shown in figure 9, the projection 106 being positioned at lid top is positioned at annular seal space 108, and, the diaphragm seal 201 on the top of this projection 106 distance catcher has certain distance.
Then, rotate lid 100, the screw thread 105 of lid portion outside and the screw thread 402 of the second inside cavity are mutually twisted, lid 100 is moved downwards along the first cavity 300 and the second cavity 400, arrive two positions, as shown in Figure 10, now, because applicator 200 is fixed together by spring 204 with lid 100, applicator 200 moves along with the movement of lid 100, thus the spring 204 in applicator comes into contact with the accent 305 of the first cavity, because spring 104 has elasticity, oppressed by the accent 305 of the first cavity and inwardly resilience, the platform 2041 on spring is made to start the perforate 101 away from lid, so that applicator 200 departs from fixing connection with lid 100, as shown in Figure 10.And as shown in Figure 11, because catcher 200 and lid 100 are fixedly connected, there is not the change of position between lid 100 and catcher 200, thus the projection 106 of lid does not also change apart from the distance of diaphragm seal 201.
Rotating lid 100 again, lid 100 continues to move down along the first cavity 300 and the second cavity 400 in the way of threaded engagement, makes lid 100 arrive the second protruding 311 places of the rib in the first cavity.As shown in figure 12, in this process moved, because applicator 200 departs from fixing connection with lid 100, then continue in the process moved down at lid 100, applicator 200 is no longer along with lid 100 moves, namely applicator 200 is relative to the invariant position of the first cavity 300 and the second cavity 400, and namely the accent of the first collecting chamber contacts with the center of the spring of catcher.And the position between applicator 200 and lid 100 changes；Along with moving down of lid 100, the annular seal space 108 between lid 100 and applicator 200 reduces, as shown in figure 12, so, the lid projection 106 being positioned at annular seal space moves closer to the diaphragm seal 203 on applicator top, finally arrives diaphragm seal 203 and punctures diaphragm seal, as shown in figure 13.Annular seal space 108 is connected with the cavity 210 of applicator, buffer solution in annular seal space 108 is flowed in the cavity 210 of applicator, eventually arrive on the absorber element 207 in applicator, mix fully with the sample collected on absorber element 207, the sample on absorber element is carried out pretreatment.On the top of applicator cavity 210, having the groove 203 of a big funnel type, for holding the projection 106 of lid, meanwhile, the liquid being also convenient in annular seal space 108 is flowed in the cavity 210 of applicator.
Again rotating lid, lid 100 continues to move down along the first cavity 300 and the second cavity 400.As shown in figure 14, now, in the process that lid moves down between the first cavity 300 and the second cavity 400, because the second projection 311 on rib touches opening 109 place of lid 100, continue in the process moved down at lid 100, lid opening 109 is urged in the second projection 311 so that the second protruding 311 resiliences, related whole rib 310 inward compression.The first projection 312 being positioned on rib is forced to bounce back to the first cavity 300, thus first protruding 312 departs from the through hole 405 of the second cavity, as shown in figure 14.Once first protruding 312 departs from through hole 405, the first cavity 300 is then no longer fixing with the second cavity 400 to be connected, and position can be occurred therebetween to move.Additionally, as shown in figure 15, lid moves to the top of applicator, namely annular seal space 108 by compression without, that is, when lid moves down again, catcher is inconjunction with and moves together.
Again rotating lid 100, lid continues to move down along the first cavity 300 and the second cavity 400, and now, because catcher 200 has arrived at the top of lid 100, therefore, the two moves together.In the process of movement, the accent 305 of the first cavity arrives the top of the spring 204 of catcher, also arrives at projection 111 place that the top and the bottom of lid have a common boundary simultaneously, and is stopped by lid 100, no longer moves, as shown in figure 16.And, now the absorber element 207 on catcher is because of the Distance Shortened between the first cavity and catcher, making the absorber element 207 space in the middle cavity 303 of the first cavity reduce and be compressed, the mixed liquor on element 207 is flowed in the first cavity in cavity 303, as shown in Figure 16 and Figure 17.nullMeanwhile，Owing to the first projection 312 before is departing from the hole 405 of the second cavity，First cavity 300 departs from fixing connection with the second cavity 400，After lid rotates，First cavity 300 arrives first at projection 111 place of lid and is blocked and fixes，When lid 100 continues to rotate，The first cavity 300 is driven to move down in the second cavity 400，First cavity 300 is moved down in the second cavity 200，The first cavity is finally made to arrive the primary importance of the second cavity，Now，Seal washer 301 on the lower chamber of the first cavity arrives accent 4061 place of the inner chamber body 406 in the second collection chamber，Inner chamber body 406 is sealed，As shown in figure 16，Now，The lower chamber 306 of the first cavity 300 and inner chamber 406 body of the second cavity form an airtight cavity，This airtight cavity is only connected with middle cavity 303 by through hole 307，And be connected with test chamber 500 by through hole 408，As shown in figure 17.
Again rotating lid, now, applicator 200 and the first cavity 300 continue to move to together along with lid 100 in the second cavity 400, make the first cavity 300 arrive the second position of the second cavity.As shown in Figures 18 and 19, in the process that lid moves, absorber element is compressed again, mixed liquor all of on it is discharged in middle cavity 303, and it is flowed in airtight cavity by through hole 307, compression along with absorber element, the drain of final absorber element also blocks through hole 307, and, cavity 303 sidewall is also sealed by the packing ring 208 being arranged on absorber element, making airtight cavity and test chamber 500 form the space sealed, the air sealed in the space of this sealing and liquid are all fixing amounts.In the process that lid 100 continues to move to, first body 300 continues deeper into the second cavity 400, make the lower chamber 306 of the first cavity completely in inner chamber body 406, and, the space 406 sealed is further compressed so that the air pressure in space increases, so that the certain quantity of fluid in inner chamber body 406 enters test chamber 500 by through hole 408, and arrive detecting element place, it is finally completed the detection of sample.Wherein, the amount of liquid entering test chamber is rotated by lid thus the size in space of compression seal determines.
After detection completes, as shown in Figure 20 and Figure 21, this collection device 800 is inverted, makes sample unnecessary in test chamber 500 can be back to collecting chamber, now, convolution lid 100, makes airtight space pressure reduce, and most end form negative pressure, the backflow of more convenient liquid, the liquid of backflow is flowed on absorber element 207 by through hole 307, is flowed in collection bar cavity 201 again through absorber element, eventually arrives in liquid storage cylinder 106.When needs sample, open stopple 102, from through hole 103, sample is taken out.
Claims (45)
1. a device, including the first cavity and the second cavity, wherein, the first cavity is positioned at the second cavity；Described first cavity can seal the second cavity；Further, the first cavity can compress the second cavity and makes the liquid in the second cavity by quantitative discharge.
2. device according to claim 1, it is characterised in that the first cavity and the second cavity are for being flexibly connected.
3. device according to claim 2, it is characterised in that the first cavity and the second cavity can be mutually shifted between the first cavity and the second cavity after separating.
4. according to the device one of claim 1-3 Suo Shu, it is characterised in that the first cavity has primary importance and the second position on the second cavity.
5. device according to claim 4, it is characterised in that when the first cavity is positioned at primary importance, the first cavity seals the second cavity, forms the cavity sealed.
6. device according to claim 4, it is characterised in that when the first cavity is positioned at the second position, the cavity of sealing is compressed by the first cavity, and the liquid in annular seal space body is quantitatively discharged.
7. device according to claim 2, it is characterised in that make the fixing connection of two cavitys and separate with the connection of the through hole of the second cavity with separating by the first projection of rib on the first cavity.
8., according to the device one of claim 1-7 Suo Shu, it is characterised in that this device also includes applicator, this catcher has sealing cavity；Seal cavity to be connected by channel liquid with the absorber element on catcher.
9. device according to claim 8, it is characterised in that this device also includes a lid, and lid forms the sealing cavity on catcher with catcher.
10. device according to claim 9, it is characterised in that lid is detachable connection with catcher.
11. device according to claim 10, it is characterised in that lid is achieved a fixed connection and separates by the moving element on catcher with the through hole cooperation of lid with catcher.
12. device according to claim 11, it is characterised in that when moving element is positioned at the hole on lid, lid is fixing with catcher to be connected；When moving element departs from the hole on lid, can move between lid and catcher.
13. device according to claim 11, it is characterised in that by the movement between lid and catcher, the volume of sealing cavity is made to reduce or increase.
14. device according to claim 11, it is characterised in that by the movement between lid and catcher, sealing cavity is made to be connected by passage with the absorber element of catcher.
15. one of-14 described devices according to Claim 8, it is characterised in that described passage includes the collection bar of hollow, collects bar one end and connects absorber element, and the other end is sealed and connects sealing cavity.
16. device according to claim 15, it is characterised in that poke, by the projection in annular seal space body, the diaphragm seal collecting masthead end and make sealing cavity connect with collection bar and the absorber element of hollow.
17. according to the device one of claim 1-16 Suo Shu, it is characterised in that this device also includes test chamber, and test chamber is connected with the sealing cavity of the second cavity.
18. according to the device one of claim 1-17 Suo Shu, it is characterised in that when lid and the catcher of fixing connection insert after in the first cavity, catcher is positioned at the first cavity and seals the first cavity；Lid is between the first cavity and the second cavity.
19. device according to claim 18, it is characterised in that the first cavity forces the moving element of catcher to depart from the through hole on lid.
20. device according to claim 19, it is characterized in that, when lid is moved relative to catcher, the sealing cavity on catcher that lid and catcher are formed is compressed, the projection contacts on top poke the diaphragm seal collecting masthead end in lid, seals cavity and is connected with the cavity of collection bar.
21. device according to claim 20, it is characterised in that lid forces the first protruding through hole departing from the second cavity on the rib of the first cavity.
22. device according to claim 21, it is characterised in that including the second projection on the rib of the first cavity, lid oppresses the second projection makes rib bounce back；The thereon first protruding through hole departed from the second cavity after rib retraction.
23. device according to claim 22, it is characterised in that when applicator rotates together with lid in the first chamber and the second cavity, absorber element is compressed in the first cavity, and liquid flows in the first cavity and the second cavity；First cavity moves to reach the primary importance of the second cavity along with lid together with catcher, and the first cavity seals the second cavity and forms sealing cavity.
24. device according to claim 23, it is characterised in that when the first cavity rotates the second position arriving the second cavity together with lid, sealing cavity and compressed, the liquid quantitative in annular seal space body enters test chamber.
25. device according to claim 18, it is characterised in that cover outer surface and the second cavity inner surface have the screw thread being mutually twisted.
26. a kind of method collecting sample, it is provided that device collecting sample, this device includes the first cavity and the second cavity, and the first cavity is positioned at the second cavity, and the two is detachable connection and liquid communication；Described first cavity can seal and compress the second cavity makes the liquid quantitative in the second cavity discharge.
27. method according to claim 26, it is characterised in that the first cavity can rotate mutually with the second cavity；Making the first cavity turn to the primary importance of the second cavity, the second cavity is sealed by the first cavity.
28. method according to claim 27, it is characterised in that make the first cavity turn to the second position of the second cavity, the second cavity of sealing is compressed, and makes its interior liquid quantitatively be discharged.
29. method according to claim 28, it is characterised in that this device also includes applicator and the lid of movable connection；Applicator includes the collection bar of hollow, collects masthead end and is sealed by diaphragm seal, and end is connected with absorber element and connects；Lid forms, with collecting masthead end, the annular seal space being positioned on catcher.
30. method according to claim 29, it is characterised in that make the applicator of fixing connection and lid be inserted in the first cavity and the second cavity；Rotating cover, the moving element in the first cavity compressing applicator forces applicator to depart from fixing connection with lid.
31. method according to claim 30, it is characterised in that be rotated further by lid, lid and applicator is made mutually to rotate, sealing cavity on catcher is compressed, the projection contacts on top poke the diaphragm seal collecting bar masthead end in lid, seals cavity and is connected with the cavity of collection bar；The buffer being positioned at annular seal space body is flowed on absorber element by the cavity connected.
32. method according to claim 31, it is characterised in that be rotated further by lid, lid oppresses the rib on the first cavity forces the first cavity of detachable connection to depart from the second cavity.
33. method according to claim 32, it is characterised in that be rotated further by lid, lid rotates together with applicator in the first cavity and the second cavity, and absorber element is compressed in the first cavity, and liquid flows in the first cavity and the second cavity；First cavity moves to reach the primary importance of the second cavity along with lid together with catcher, and the second cavity is sealed to be formed and seals cavity by the first cavity.
34. method according to claim 33, it is characterised in that be rotated further by lid, making the first cavity move to the second position in the second cavity, seal cavity and compressed, the liquid quantitative in annular seal space body enters and is attached thereto logical test chamber.
35. a sample collection device, including applicator, wherein, catcher has sealing cavity.
36. device according to claim 35, it is characterised in that sealing cavity can be connected by channel liquid with the absorber element on catcher.
37. device according to claim 36, it is characterised in that this device also includes a lid, and lid forms the sealing cavity on catcher with catcher.
38. the device according to claim 37, it is characterised in that lid is detachable connection with catcher.
39. the device according to claim 38, it is characterised in that lid is achieved a fixed connection and separates by the moving element on catcher with the through hole cooperation of lid with catcher.
40. the device according to claim 39, it is characterised in that when moving element is positioned at the hole on lid, lid is fixing with catcher to be connected；When moving element departs from the hole on lid, can rotate between lid and catcher.
41. device according to claim 40, it is characterised in that by the movement between lid and catcher, the volume of sealing cavity is made to reduce or increase.
42. device according to claim 40, it is characterised in that by the movement between lid and catcher, sealing cavity is made to be connected by passage with the absorber element of catcher.
43. according to the device one of claim 35-42 Suo Shu, it is characterised in that described passage includes the collection bar of hollow, collect bar one end and connect absorber element, the other end is sealed and is connected sealing cavity.
44. device according to claim 43, it is characterised in that poke, by the projection in annular seal space body, the diaphragm seal collecting masthead end and make sealing cavity connect with collection bar and the absorber element of hollow.
45. device according to claim 35, it is characterised in that in annular seal space body, there is buffer solution.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310651785.4A CN104697811A (en) | 2013-12-05 | 2013-12-05 | Sample collection apparatus and method thereof |
| CN2013106517680 | 2013-12-05 | ||
| CN201310651768.0A CN104697816A (en) | 2013-12-05 | 2013-12-05 | Device and method |
| CN2013106517854 | 2013-12-05 | ||
| PCT/CN2014/092625 WO2015081818A1 (en) | 2013-12-05 | 2014-11-30 | Device and method |
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| CN105814430A true CN105814430A (en) | 2016-07-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201480065961.9A Pending CN105814430A (en) | 2013-12-05 | 2014-11-30 | Device and method |
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| CN (1) | CN105814430A (en) |
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Application publication date: 20160727 |