CN1842299A - Biological specimen collection and analysis system - Google Patents
Biological specimen collection and analysis system Download PDFInfo
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- CN1842299A CN1842299A CN 200480024403 CN200480024403A CN1842299A CN 1842299 A CN1842299 A CN 1842299A CN 200480024403 CN200480024403 CN 200480024403 CN 200480024403 A CN200480024403 A CN 200480024403A CN 1842299 A CN1842299 A CN 1842299A
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Abstract
Disclosed is a device for collecting a fluid specimen. The device comprises a container that can receive a fluid specimen; a plunger movably positioned within the container, wherein the plunger can move from an initial position at an upper region of the container to a secondary position below the first position; a fluid segregation chamber that can receive a portion of the fluid specimen from the container, wherein any fluid in the segregation chamber is segregated from the fluid specimen in the container; a fluid flow lumen that provides a passageway for at least a portion of the fluid specimen to flow into the fluid segregation chamber, wherein a first end of the passageway has a first opening that opens into the fluid segregation chamber and a second end of the passageway has a second opening that can receive at least a portion of the fluid specimen; and a seal member that covers the first opening or the second opening to prevent fluid from flowing therethrough. A test element can be used to push the plunger from the initial position toward the secondary position to break the seal member and cause at least a portion of the fluid specimen to flow through the second opening into the fluid flow lumen and into the fluid segregation chamber through the first opening.
Description
Field that the present invention belongs to
The present invention relates generally to sample collection device, more specifically, be meant a kind of a part of system of fluid sample that is applicable to that isolation and analysis are collected.
Description of related art
We can carry out one or multinomial detection at frequent hope on a human body body fluid sample, such as having determined whether that illicit drug exists or whether detection is conceived.This body fluid sample is collected in the container generally speaking, and good seal is sent to inspection center then.The staff opens container then and therefrom takes out a part of body fluid sample and be placed on the detecting element, such as a test card, is used for determining whether have certain material in this body fluid sample.
As everyone knows, body fluid sample has very strong infectivity.Therefore, when the detection bodies fluid samples, wish sample portion to be detected and operator and environment are on every side kept apart.A reason of doing like this is to reduce body fluid sample to pollute the probability of surrounding and reduce the infected probability of operator.Another reason is that minimizing operator and surrounding pollution body fluid sample cause the inaccurate probability of testing result.
In some cases, wish that only taking out a part of body fluid sample detects, and remaining part still is in interference-free situation.In this case, an emphasis of being paid close attention to is that detected that part of body fluid sample can not pollute remaining not detected body fluid sample.Therefore, wish that the catcher prodigiosin enough provides a kind of method to come certain a part of body fluid sample is isolated, thus that part of body fluid sample of separating and remaining part without any contact.
In sum, be necessary very much to invent a kind of body fluid sample gathering system, this system can collect body fluid sample under a kind of safe mode, to reduce the risk factor of polluting, can easily a part of body fluid sample be separated on the other hand.
Summary of the invention
The present invention relates to a kind of device that is used for the collection body fluid samples.This device comprises a container that can receive body fluid sample; One can be moved the localized piston of realization in container, this piston can move to another position that is lower than initial position from the initial position of container top; A fluid segregation chamber, this chamber can receive a part of body fluid sample from container, and like this body fluid in isolation room and the body fluid sample in the container are separated; A fluid flow cavity, this chamber provides a passage, and the part body fluid sample is flow in the body fluid separate cavities, and an end of this passage has one first opening, this opening communicates with fluid segregation chamber, and the other end has one second opening can receive a part of body fluid sample; And a sealing member, prevent that body fluid from flowing thereby be used for stopping up first or second opening.A detecting element is used to promote piston and moves to the another location from an initial position, and sealing member is opened, and second opening enters into fluid flow cavity thereby a part of body fluid sample is flowed through, and enters into fluid segregation chamber by first opening then.
The invention still further relates to a kind of method of analysing body fluid sample.This method comprises provides a container to be used for adorning body fluid sample, this container comprises that a fluid segregation chamber is used for isolating at least the body fluid of a part from whole body fluid sample, fluid flow cavity provides a fluid flowing passage there, can allow a part of body fluid sample to flow into from container in the fluid segregation chamber, the sealing member on the fluid flow cavity can stop body fluid to flow in the fluid flow cavity; And in container, insert a detecting element, sealing member is opened, and this detecting element presses down piston makes a part of body fluid flow in the container enter into fluid segregation chamber through fluid flow cavity, wherein, this detecting element at least a portion will enter into fluid segregation chamber, is immersed in the body fluid sample of the inside.
The present invention also relates to a kind of device of collection body fluid samples.This device comprises a container, forms a main chamber and receives body fluid sample; A fluid segregation chamber that matches with container is used for isolating a part of body fluid sample from the body fluid sample of main chamber and is used for detecting; A fluid flow cavity is used to body fluid to flow to fluid segregation chamber from main chamber provides a passage, and this fluid flow cavity has a upper shed to lead to fluid segregation chamber; A sealing member stops up the upper shed of fluid flow cavity to prevent that body fluid flow is through upper shed; And a piston that matches with container, piston can move down a part of body fluid sample of the compressing fluid flow cavity of flowing through and enter into fluid segregation chamber in container, and wherein, sealing member must be opened when piston moves down.
Other features and advantages of the present invention below will at length be told about by means such as accompanying drawing and some specific embodiments, describe by limited this simultaneously and illustrate substantive features of the present invention.
Description of drawings
Fig. 1 is the axonmetric chart under the specimen collection system assembled state of the present invention.
Fig. 2 is the axonmetric chart under this specimen collection system disassembled state.
Fig. 3 is the cutaway view that the specimen collection system under this assembled state is cut open along the 3-3 line in Fig. 1.
Fig. 4 is the cutaway view that the specimen collection system under this assembled state is cut open along the 4-4 line in Fig. 1.
Fig. 5 is the cutaway view of a specimen collection system under the assembled state that includes a biological specimen.
Fig. 6 is a cutaway view that comprises the specimen collection system under the assembled state that a sample and test card to be ready preparing to detect.
Fig. 7 is a cutaway view with the specimen collection system under the assembled state that obtains behind the view half-twist among Fig. 6.
Fig. 8 is that test card is inserted the cutaway view that a part of sample in back flow into the specimen collection system under the assembled state in the fluid segregation chamber.
Fig. 9 is the cutaway view of the specimen collection system of a test card under the assembled state on the detection position.
Figure 10 is the cutaway view of the specimen collection system under another assembled state under the state shown in Figure 9, and this view obtains after with Fig. 9 half-twist.
Figure 11 is the axonmetric chart of second embodiment of this specimen collection system.
Figure 12 is the exploded view of the specimen collection system of Figure 11.
Figure 13 is the cutaway view of the specimen collection system of Figure 11.
Figure 14 is the cutaway view of the specimen collection system of Figure 11.
Figure 15-17 is depicted as the use step of specimen collection system.
Describe in detail
Definition
Unless otherwise defined, all technology have identical implication with scientific terminology with the employed term of the those skilled in the art of this technical field that the present invention belongs to as used herein.
" chemical examination " expression detects or tests a kind of material or whether material exists, such as, but be not limited to this, the metabolite of chemical substance, organic compound, inorganic compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymer.In addition, the quantity of chemical examination expression test substances or material.Furtherly, immune detection, chemical detection, enzyme detection etc. are also represented in chemical examination.
" sample " refer to need chemical examination whether to exist and (or) any material of analyzing samples concentration, maybe need to determine whether one or more samples exist and (or) material of quantity, maybe need to carry out the material of qualitative evaluation.Sample can be fluid sample, for example fluid sample.Fluid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tear, seminal fluid and bone marrow; Sample can be a water sample, such as sea water, river, river etc., perhaps from domestic water, municipal water use or industry water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making fluid, eluate, suspension or leachate equal samples.For example, throat or genitals sample may be dipped in and make sample in the fluid.Sample can comprise mixture or any relevant mixture of fluid, solid and gas, such as the cell suspending liquid in diluent or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Fluid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, feces, tissue, organ, biological fluid or other occurring in nature nonfluid samples.For example, these solids or semi-solid samples can be mixed with the suitable solution of diluent one class.Sample can be macerated, freezing and thaw, perhaps other extracting method form fluid samples.Remaining particulate material can use traditional method such as filtration or precipitation to remove.
Sample collection and analytical system
Fig. 1 is a specimen collection system axonmetric chart that assembles.Fig. 2 is a specimen collection system axonmetric chart of taking apart.This system comprises container 110, lid 115, piston shell 120, piston 125 and a detecting element, as test card 130 (test card 130 as shown in Figure 2).Describe each parts of system below in detail.
Testing element shown in the figure is a test card 130, but also can be any device that can be used for assay samples.The size and dimension of test card should guarantee can be inserted in the container 110, and detail is as described below.The size and dimension that it should be noted that test card 130 can change to some extent.
With reference to figure 1 and Fig. 2, container 110 general appearances are cup-shapeds, and an end opening upwards can the splendid attire fluid sample with Bedpan 110.An opening of the top edge 128 (as shown in Figure 2) on the container 110 is used to receive fluid.In addition, the top edge 128 on the container has the screw thread that is complementary with the screw thread of lid on 115, can make cover 115 and container 110 be bound up.The assembling mode of other kinds also can be used for connecting covers 115 and container 110, such as press insert type or bayonet type.
As can be seen from Figure 1, the ring flange 134 that lid 115 has a pedestal 132 and extends downwards, its shape is consistent with the edge 128 on the container 110, so that ring flange 134 can match with edge 128, such as insert ring flange 134 on edge 128.As shown in the figure, pedestal 132 has a ring-shaped depression base, can place another container 110 at lid 115 tops like this.What need prompting is that pedestal 132 also can be flat, will tell about in addition below.
The inner surface of ring flange 134 has screw thread to match with edge 128 on the container 110.To cover 115 by this spiral marking connection mode is bound up with container 110.Such as, will cover 115 during installation and be placed on the container 110 and swivelling cover 115, the screw thread of container 110 top edges 128 is bound up with covering the threaded engagement on 115.Between lid 115 and container 110, to place one at least and seal (as shown in Figure 2) such as O RunddichtringO 210.
Can see that from Fig. 1 and Fig. 2 test card slot 135 is passed and covered 115 pedestal 132.The size of test card slot 135 and test card 130 are complementary, and will at length introduce below.The shape and size of test card slot 135 are consistent with the shape and size of test card 130, so that in use can smoothly test card 130 be inserted in the test card slot 135.More particularly, the shape of test card 130 is level and smooth rectangles.Correspondingly, the shape of test card slot 135 is rectangular, and test card 130 is inserted smoothly.Test card slot 135 also can be other shape so that match with difform test card 130 in fact.
As shown in Figure 2, the centrage in hole 215 and lid 115 central lines, the degree of depth in hole will guarantee at least to pack into the part of piston shell 120.The top in hole 215 and bottom are openings, the chamber that extends out downwards of tegmentum 115 218 sealings all around.The shape of chamber 218 is consistent with the external shape of piston shell 120.In this way, after system was assembled, hole 215 can receive piston shell 120.In cited embodiment, piston shell 120 and chamber 218 are cylindraceous, can certainly be other shapes.Test card slot 135 is also passed chamber 218.
As depicted in figs. 1 and 2, intersect with test card slot 135 in hole 215, so that the space is positioned at the center of groove.Groove chamber 220 (as shown in Figure 2) is with test card slot 135 sealings.Extend downwards from covering pedestal 132 places groove chamber 220, and 218 stretch out from the chamber.
The top part of groove chamber 220 and piston shell 120 has formed inner fluid segregation chamber 225 (as shown in Figure 4) jointly, and this part will at length be told about below.Test card slot 135 communicates with fluid segregation chamber 225, provides a passage to make test card 130 can be inserted into fluid segregation chamber 225.As described below, in use, fluid segregation chamber 225 receiving unit fluid sample from container 110 when piston 125 moves down.
With reference to figure 2, the shape of piston shell 120 be one extended cylindrical.Piston shell 120 has a ring-type lining 121.Plunger shaft 230 vertically extends through piston shell 120.Plunger shaft 230 forms a space at the top of piston shell 120, and this spatial size matches with piston 125.Plunger shaft 230 is sealed (as shown in Figure 3) in its bottom by the bottom 122 of piston shell 120.Low side in piston shell 120 has a fluid inflow entrance 240 of being made up of a hole or opening at least.
A pair of relative test card slot 235 is passed through the top of piston shell 120.Test card slot 235 and the test card slot 135 on lid 115 are point-blank after assembling.As shown in Figure 1, the test card slot 135 in lid 115 and single cavity of the 235 common formation of the test card slot in piston shell 120 are so that test card 130 can be passed.
With reference to figure 2, piston 125 comprises an elongated piston arm 250.Fluid flow cavity 252 vertically extends through piston arm 250, thereby fluid flow cavity 252 has formed the opening that passes piston arm 250 tops and bottom.Fluid can enter into fluid segregation chamber 225 from container 110 by fluid flow cavity.
Still with reference to figure 2, director element 255 is spaced apart along piston arm 250 length.Director element 255 is made up of the projection that extends outward from piston arm 250.Have at least the shape and size of a director element 255 and the shape and size in the inner carrier chamber 230 on the piston shell 120 to be consistent.In this way, piston 125 can no big displacement swingingly slide up and down the adjustment that realizes the position under the guiding of director element 255 in plunger shaft 230.Director element 255 can be combined closely with the inwall of plunger shaft 230, thereby prevents that fluid from flowing between the inwall of plunger shaft 230 and director element 255.In cited embodiment, piston 125 comprises and is positioned at piston arm 250 vertical director element 255a, is positioned at the director element 255b at piston arm 250 middle parts and is positioned at the director element 255c of piston arm 250 bottoms.Certainly, piston 125 can comprise more or less director element 255, and director element 255 can and be distributed on the piston arm 250 with different positions.
The specimen collection system that assembles can be by being explained in more detail with reference to figure 3 and Fig. 4.Fig. 3 is the cutaway view that the system under this assembled state cuts open along the 3-3 line in Fig. 1, and Fig. 4 is the system's cutaway view that 4-4 along the line cuts open in Fig. 1 under this assembled state.According to Fig. 3, under assembled state, lid 115 is bound up with container 110 tops.The front was mentioned, and lid 115 and container 110 all have screw thread, can make cover 115 and container 110 connect by screw thread.Adding one or more O type circles between lid 115 and container 110 seals.Lid 115 and container 110 can use other bind modes to connect.
With reference to figure 3, after system assembles was got up, piston shell 120 was total to centrage with chamber 218, can make chamber 218 at least around a part of piston shell 120 like this.The upper end of piston shell 120 is supported by lid 115, and piston shell 120 remaining parts extend downwardly into container 110.In this regard, there is a flange 310 on the top of piston shell 120, is positioned at the sagging pedestal 315 that covers on 115, so that smooth installation cover 115 and piston shell 120.We can say that piston shell 120 and lid 115 form an integral body.Can be assembled into the different assemblies of fluid collection system according to design and manufacturer's standard by one or more composite members.
In one embodiment, the size of piston shell 120 must design the bottom that is positioned at container 110 with assurance fluid intake 240 when piston shell 120 is positioned at hole 215.Such design has improved the probability that fluid sample in container 110 flow into fluid intake 240.Certainly, the position of fluid intake 240 can change to some extent.
With reference to figure 3, slide in the plunger shaft 230 of piston 125 in piston shell 120.Mentioned above, the shape and size of director element 255 will be consistent with the size and dimension of plunger shaft 230 in the piston shell 120.In this way, piston 125 can be implemented in slip and firm location in the plunger shaft 230 by combining closely of director element 255 outward flanges and plunger shaft 230 inwalls.Locate in this way, piston arm 255 axle center overlap with the vertical axis 317 of plunger shaft 230.
As shown in Figure 4, the length L of piston 125 is shorter than the length L 1 of plunger shaft 230.Correspondingly, relative length provides corresponding space in plunger shaft 230, guarantees can move up and down in the plunger shaft 230 of piston 125 in piston shell 120.
At initial position as shown in Figure 3, the top of piston 125 be positioned at piston shell 120 near.Mentioned above, the length L of piston 125 is smaller than the length L 1 of plunger shaft 230.When piston 125 is in original state, the bottom of piston 125 is positioned at the top of fluid intake 240 on the piston shell 120.In addition, length L and L1 have guaranteed to form an apotheca 318 in plunger shaft 230 lower ends.The director element 255c of piston 120 lower ends has constituted the upper end of apotheca 318.The inwall of piston shell 120 has constituted the wall all around of apotheca 318, and the interior bottom wall 122 of piston shell 120 has constituted the lower end of apotheca 318.
As shown in Figure 3, sealing member 320 is positioned at the top of piston 125.The upper end open that sealing member 320 covers fluid flow cavity 252 is fully sentenced and is prevented that fluid from flowing into separate cavities 225 from fluid flow cavity.In one embodiment, sealing member 320 is made the band shape by cohesive material, and its size and dimension must guarantee the opening of fluid flow cavity 252 upper ends is covered fully.The material of sealing member 320 will guarantee having under the enough big pressure and can be opened.
According to discussed above, cover a part of 115 at least and form fluid segregation chamber 225 and communicate with test card slot 135.From Fig. 4, can see this point in more detail.Fluid segregation chamber 225 is cells that are included in groove chamber 220 and the piston shell 120.As described below, the part of test card 130 can be inserted in the influent stream body separate cavities 225 by groove 135 and the groove in the piston shell 120 235 that covers in 115 at least.Bottom design in test card 130 has a kind of structure, can open sealing member when test card 130 is inserted in the groove.Embodiment shown in Figure 2, test chart 130 comprise a sting device of being made up of sharp thrust 155, and this device is used to wear out sealing member 320.
Use as for this specimen collection system can be described with reference to figure 5-10 at this.The first step, a fluid sample is first collected in the container 110.Give an example, provide biological sample jointly by design containers 110 and separable lid 115.This object is collected fluid sample in the container 110 by the mode that slowly flows into then.Can certainly provide sample by alternate manner.Lid 115 can be used with container 110, can perhaps can use other some frame for movements such as the mode by spiral lid 115 and container 110 secure fit together.Therefore, by the container 110 of screwing hermetic, just as shown in Figure 5, can be used for containing fluid sample 510.Sample 510 is contained in the primary tank 512 that is arranged in container 110, and wherein, the separate cavities 225 in primary tank 512 and the container 110 is (as shown in Figure 7) of separating.Have at least the sample 510 of a part 240 to flow in the apotheca 318, shown in arrow among Fig. 5 514 by entering the mouth.
In this process, the fluid sample in apotheca 318 can not flow into fluid flow cavity 252, because this fluid flow cavity 252 comprises air, and uses sealing member 320 with its sealing or be closed in its upper end.In addition, formed a hermetically-sealed construction at the inwall of the director element 255c of bottom and piston shell 120 and prevented that any fluid from flowing between the inwall of director element 255c and piston shell 120.Therefore, this bottom guide member 255c can stop sample upwards to flow to bottom guide member 255c through piston shell 120.Even some fluid samples should incoming fluid flow cavity 252,, sealing member 320 stoped sample 510 to flow in the separate cavities 225 thereby having covered the top of sample 510.
With reference to figure 6 and Fig. 7, test chart 130 is in turn inserted in the test card slot of covering in 115.Test chart 130 moves down, and the ledge 155 that is positioned at test chart 130 bottoms is worn out sealing member 320, like this just passes a hole on sealing member 320.This sealing member that is the worse for wear 320 can provide the space of an opening between the upper end of fluid flow cavity 252 and separate cavities 225 so.Can well find out that from Fig. 7 the bottom of test chart 130 puts in the separate cavities 225 via test card slot.In this operational phase, separate cavities 225 is empty.That is to say that do not hold any sample 510 in the separate cavities this moment.
As can be seen from Figure 7, the upper end of the bottom of test chart 130 and piston 125 is adjacent.More particularly, although test chart 130 can be adjacent with the other parts of piston 125, the bottom of test chart 130 and top director element 255a also are adjacent.When test chart 130 was in as shown in the figure position with respect to piston 125, test chart 130 can be used to promote piston 125 along piston shell 120 downward directions.
With reference to 8, one users of figure along downward direction push to test card 130.Because test chart 130 is adjacent with the upper end of piston 125, so when test chart 130 moves down, test chart 130 will promote piston 125 and move downwards.Therefore the director element 255c of the bottom of piston 125 is also to the slide inside of apotheca 318, and reduced the capacity of apotheca 318.Because it is to the apotheca slide inside, so in apotheca 318, the director element 255c of bottom has occupied some fluidic spaces.
When above-mentioned action took place, the director element 255c of bottom moved down from fluid intake 240, as shown in Figure 8.As last said, the bonding part between the director element 255c of bottom and the inwall of plunger shaft 230 seals, and flow into 240 li of fluid intakes so director element 255c can prevent sample 510.Therefore, the fluid sample 510 in the apotheca 318 just can not flow out from apotheca 318 through fluid intake 240.Because moving downward of piston 125 so the capacity of apotheca 318 descends, causes fluid sample 510 upwards to flow in the fluid flow cavity 252 via the hole of piston 125 bottoms, shown in the arrow among Fig. 8 810.Said as the front, sealing member 320 has been the worse for wear, and causes the upper end of fluid flow cavity 252 open, therefore when fluid sample flow into fluid flow cavity 252, can exclude the air in the fluid flow cavity 252.
As Fig. 9 and shown in Figure 10,, cause the part 910 in the fluid sample 510 that is stored in the apotheca 318 to continue upwards to flow by fluid flow cavity 252 because piston 125 moves downward.Finally, the part 910 of fluid sample 510 flow in the separate cavities 225 via fluid flow cavity 252 open upper ends.Therefore, the part 910 of fluid sample 510 can be full of the segment space of separate cavities 225 at least, as Fig. 9 and shown in Figure 10.If the said generation in front, test chart 130 has moved down, so test chart 130 has at least a part also to extend in the separate cavities 225.If so, test chart 130 will directly touch the fluid sample that is contained in the separate cavities 225.
Second embodiment of this specimen collection system described now.Unless other mark is arranged, the same parts of same digitized representation.With reference to Figure 11 and Figure 12, second embodiment comprises container 110 and lid 115.Groove 135 directly is installed in and covers on 115.
Can well find out that from Figure 12 therefore sealing strip 1210 can sealing cover groove 135 well covering running fix on 115.Sealing strip 1210 can use flexible well material manufacture.Bottom gasket 1205 directly is fixed on groove 135 following covering.
Still with reference to Figure 12, piston shell 1210 comprises a cap interface 1211, this interface have one can with lid 115 bottoms intermeshing structure.In said embodiment, cap interface 1211 has the parts of the disc shape of a circle, and these parts meet the shape of covering 115 bottoms, therefore can make this cap interface and lid 115 engagement very smoothly.Certainly, we agree that also cap interface 1211 can make other shape.
In addition, piston shell 1210 also comprises a container holder 1217, and this container holder can encase internal segregation chamber 225 at least partially or entirely, and test chart 130 can be inserted in this separate cavities 225 via groove 135.Here, being used for the groove 1218 of correspondence of acceptance test card 130 is fixed on 1211 li of cap interface.
In addition, piston shell 1210 also comprises cylindrical member 1212, and these parts extend downwards from cap interface 1211.Embodiment as the front is said, and this cylindrical member 1212 comprises the plunger shaft 230 of an inside, and piston 125 can slide at this intracavity.On cylindrical member 1212, be provided with a fluid intake 240 at least, can provide a fluid that communicates with plunger shaft 230 to flow into point like this.
Still with reference to Figure 12, cylindrical guide 1215 by with certain size packaged type be installed in the plunger shaft 230.This cylindrical guide 1215 has the inner chamber of an inside, and this inner chamber can receive the part above the piston 125 portablely.This cylindrical guide 1215 comprises one or more brake component, and such as the thrust 1225 of circle, it can intermesh with corresponding director element 255 on the piston 125, guarantees the location of piston 125 in guider 1215 with this.
What Figure 13 represented is the longitudinal sectional view of this specimen collection system under the state of having assembled, and piston 125 is in initial position in the figure.Director element 255 intermeshes with thrust 1225 and guarantees that with this piston 125 is in the initial position that is positioned at above the punching machine, this punching machine by one from container 110 bottoms upwardly extending sharp sharp shaped material 1310 form.Seal member 1315 is installed in the position of piston 125 bottoms, therefore can cover the hole that is formed by fluid flow cavity 252 bottoms hermetically, and this fluid flow cavity 252 extends out by piston 125.
As shown in figure 14, force piston 125 to be moved down into second position, so that outthrust 1310 penetrates seal member 1315.Make piston 125 move to second position by test chart 130 being inserted into groove 135 interior moving downward with push to test card 130.The bottom of test chart 130 and the top of piston 125 will be joined, so make piston 125 slips and guider 1215 is moved down along plunger shaft 230.At this moment, outthrust 1310 is in the fluid flow cavity 252.We think that also outthrust 1310 can adopt other form and structure, as long as when piston 125 moves downward, it can puncture through seal parts 1315 just.
With reference to figure 15-Figure 17, to further introduce the operation of this specimen collection system now.As shown in figure 15, sample 510 is stored in 512 li of the primary tanks of container 110, and this primary tank 512 is what to separate with separate cavities 225 in the container 110, as shown in Figure 7.The upper end of fluid flow cavity 252 can be covered by sealing member 320, and its lower end also can be covered with (as shown in figure 13) by sealing member.
As shown in figure 16, have at least the sample 510 of a part 240 to flow in the apotheca 318 by entering the mouth.Test chart 130 is inserted into to be positioned at and covers 115 groove 135, and the bottom of this test chart just joins with the upper end of piston 125 like this.With reference to Figure 17, a user is along groove 135 downward push to test cards 130, and this will make piston move downward along plunger shaft 230.Test chart 130 can puncture sealing member 320 in the upper end of piston 125.As selection or corresponding with sealing member 320, thrust 1310 can be worn out following seal member 1315, and this moment, piston 125 moved downward.Therefore the opening that enters fluid flow cavity 252 is packing less, and the sample in apotheca 318 can upwards flow in the fluid flow cavity 252 like this, and can flow in the separate cavities 225.About above description to previous embodiment, test chart 130 moves down, and the part of test chart 130 also is in the separate cavities 225.Like this, test chart 130 just be stored in separate cavities 225 in fluid sample contact.
Although the embodiment of the whole bag of tricks and device here is described with some forms, we think that also other form, embodiment, using method and above associated methods also all are feasible.Therefore the spirit and scope of claim are not limited in the specific embodiment as described herein.
Claims (19)
1. device that is used to collect fluid sample is characterized in that it comprises:
A container that is used to collect a kind of fluid sample;
A removable localized piston in container, wherein, this piston can move into place from the primary importance that is in container top on the second position below primary importance;
One can be from the fluid segregation chamber of receiving unit fluid sample in the container, wherein, is isolated with the fluid sample that is stored in the container all at any fluid of this fluid isolation intracavity;
A fluid flow cavity, this fluid flow cavity provides one can make a part of fluid sample flow into the passage of this fluid segregation chamber at least, wherein, first end of this passage has first opening that can lead to fluid segregation chamber, and second end of this passage has second opening that can receive to the small part fluid sample; And
A sealing member is used for covering first or second opening, stops fluid therefrom to flow through with this;
Wherein, wear out sealing member and make at least a portion fluid sample flow into fluid flow cavity, flow into fluid segregation chamber through first opening through second opening thereby testing element can be pushed into the second position to piston from primary importance.
2. device as claimed in claim 1 is characterized in that, also comprises a lid that can cover container.
3. device as claimed in claim 1, it is characterized in that, also comprise a groove that passes lid and communicate with fluid segregation chamber, the size of this groove allows testing element to pass, and this testing element can be inserted in this groove and wear out sealing member, and push piston to the second position from primary importance, and when testing element with piston when primary importance is pushed the second position to, at least a portion of testing element moves to the fluid isolation intracavity.
4. device as claimed in claim 2, it is characterized in that this device also comprises a piston shell of being extended by lid down in container, this piston shell comprises sidewall and diapire, and have plunger shaft in this piston shell, this piston is installed in the plunger shaft with form slidably.
5. device as claimed in claim 4, it is characterized in that, an apotheca that is positioned under the piston is arranged at the bottom of piston shell, and at least one fluid intake is arranged on the inwall of piston shell, can communicate with this apotheca like this, this fluid intake provides a passage, can flow in this apotheca from container via this passage at least a portion fluid sample.
6. device as claimed in claim 5 is characterized in that, second opening of this fluid flow cavity leads to this apotheca, and when piston from primary importance when second position direction moves, at least a portion piston can stop fluid to flow in this fluid intake; When this piston towards second position moved, the fluid in this apotheca must flow into this fluid flow intracavity like this.
7. device as claimed in claim 1 is characterized in that this fluid flow cavity is positioned at this piston.
8. device as claimed in claim 4 is characterized in that this piston shell is connected with lid movably.
9. the method for an analysing fluid sample comprises:
Provide one can the contain fluids sample container, this container comprises a fluid segregation chamber, this separate cavities can be kept apart first's fluid sample and second portion fluid sample at least, wherein, fluid flow cavity provides one so that the segment fluid flow sample flow into fluid passage the fluid segregation chamber from container, and this fluid flow cavity has and stops fluid to flow into sealing member in the fluid flow cavity;
A testing element is inserted into punctures sealing member in the container, and this testing element promotes a piston downwards the segment fluid flow at least in the container is flow in this fluid flow cavity and the fluid segregation chamber; Wherein, at least a portion of testing element moves in this fluid segregation chamber, and contacts with segment fluid flow sample in this fluid segregation chamber.
10. method as claimed in claim 9 is characterized in that, also comprises lid is covered on the container, and wherein, this lid combines with a piston shell that includes plunger shaft, and described piston is placed in the plunger shaft movably.
11. method as claimed in claim 10, it is characterized in that, when this lid is meshed with container, fluid sample to small part flow into the apotheca that is positioned at the piston shell bottom, and when piston moves down,, piston force the segment fluid flow sample in the apotheca to flow in the fluid flow cavity thereby having reduced the volume of apotheca.
12. method as claimed in claim 11 is characterized in that, the segment fluid flow sample flow in the apotheca via the fluid intake at least one piston shell, and when piston was pressed down, the piston blocking portion divided fluid sample to flow out apotheca via this fluid intake.
13. method as claimed in claim 10 is characterized in that, testing element is inserted into comprise in the container via the groove that covers and insert this testing element.
14. a device that is used to collect fluid sample comprises:
A container of setting a main chamber, this main chamber can receive fluid sample;
A fluid segregation chamber that matches and be connected with container can be kept apart segment fluid flow sample and this main chamber at least;
A fluid flow cavity can provide a passage, and fluid can flow into from main chamber in the fluid segregation chamber via this passage, and the opening that this fluid flow cavity has above can lead to separate cavities;
A sealing member covers on the top opening of fluid flow cavity, can stop fluid to flow out from top opening; And
A piston that matches with container, wherein, this piston can move down the fluid sample that is forced to small part and flow in the fluid segregation chamber via fluid flow cavity, and the sealing part must be the worse for wear, so that the downward direction of this piston towards moves.
15. device as claimed in claim 14 is characterized in that, also comprises a lid that matches with container, wherein, when this lid cooperated with this container, this lid comprised that extends downward the interior piston shell of this container, and this piston is movably located in the plunger shaft in the piston shell.
16. device as claimed in claim 14 is characterized in that, the part below this piston shell forms an apotheca, and when covering when cooperating with container, the fluid sample in this main chamber flow in this apotheca via the fluid intake in this piston shell.
17. device as claimed in claim 16 is characterized in that, this fluid flow cavity has a lower opening can lead to apotheca, and when piston moved downward, this piston stoped the fluid in the apotheca to flow out from fluid intake; When piston moved downward, this piston had substituted the position of segment fluid flow sample in apotheca, caused the fluid in the apotheca to flow in the fluid segregation chamber via fluid flow cavity like this.
18. device as claimed in claim 14 is characterized in that, a testing element can be inserted in the container, and this testing element is worn out the sealing part like this, and promotes piston towards downward direction.
19. device as claimed in claim 14 is characterized in that, this fluid flow cavity is positioned at piston.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49785303P | 2003-08-25 | 2003-08-25 | |
| US60/497,853 | 2003-08-25 | ||
| US10/766,204 | 2004-01-27 |
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| Publication Number | Publication Date |
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| CN1842299A true CN1842299A (en) | 2006-10-04 |
| CN100466988C CN100466988C (en) | 2009-03-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004800244034A Active CN100466988C (en) | 2003-08-25 | 2004-08-25 | Biological specimen collection and analysis system |
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